CN102302678B - Skin membrane repair drug - Google Patents
Skin membrane repair drug Download PDFInfo
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- CN102302678B CN102302678B CN2011102735579A CN201110273557A CN102302678B CN 102302678 B CN102302678 B CN 102302678B CN 2011102735579 A CN2011102735579 A CN 2011102735579A CN 201110273557 A CN201110273557 A CN 201110273557A CN 102302678 B CN102302678 B CN 102302678B
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Abstract
The invention provides a skin membrane repair drug. The skin membrane repair drug is characterized by comprising the following bulk drugs in parts by mass: 10-20 parts of rhizoma coptidis, 5-10 parts of dragon's blood, 10-20 parts of pearl powder, 10-20 parts of bletilla striata, 5-10 parts of dahurian angelica, 25-35 parts of lithospermum and 5-15 parts of safflower. The skin membrane repair drug has the beneficial effects that compatibility between the drug and body tissues is improved, the drug can be fully absorbed by skin and the filled drug is turned into one part of the incomplete tissues, and thus efficacies of purging pathogenic fire, clearing away toxic materials, eliminating dampness, promoting blood circulation, cooling blood, stopping bleeding, relieving pain, removing blood stasis, discharging pus, resisting bacteria and diminishing inflammation, promoting tissue regeneration and the like can be fully exerted, wound healing is promoted and skin grafting procedure is omitted and no or less scars are left. The skin membrane repair drug is applicable to skin membrane repair for burn and scald wounds as well as chronic rhinitis, solar dermatitis, cheilosis, infant red buttock and the like; and the skin membrane repair drug can achieve immediate curing effect after use.
Description
Technical field
The present invention relates to a kind of medicine for external use, especially a kind of pure external Chinese medicament of repairing the damage epithelium belongs to the medicine technical field.
Background technology
Burn be the high temperature that caused by outside many reasons to the damage that skin, muscle cause, be commonly referred to pyretic toxicity and soak wound.Burn in treatment, during scald, modern doctor trained in Western medicine use more antibiotic to prevent its traumatic infection threat to life, and wound or wound surface cleaned, the processing of downright bad muscular tissue, rigorous disinfects, afterwards wrapping, also need during the treatment regularly regularly to change dressings, wound or wound surface are used any medicine hardly, only allow its self-sow, repair, but this method in fact effect is unsatisfactory, especially inflicted heavy losses at skin and injured corium, during Musclar layer, generally be difficult to repair former state, can only repair by the scar tissue that connective tissue forms, not only leave over cicatrix, even also will carry out skin grafting, thereby bring very big misery to the patient, and medical expense is extremely expensive.
The traditional Chinese medical science of China then is essentially different with doctor trained in Western medicine, the Chinese traditional treatment burn is to be used for bringing into play its drug effect with natural drug outer, take heat clearing away, detoxifcation, dampness, convergence, hemostasis, pain relieving as main, namely wound surface is left intact, after only blister being discharged water, immediately medicine-feeding, at once pain relieving alleviates the pain of injury, fully stimulates the regeneration capacity of human body cell by external used medicine, impel again Fast Growth of muscular tissue, thereby reach the therapeutic effect of short-term recovery from illness.But because difference and the human body difference of every kind of medicine ingredient cause its therapeutic effect to a lot of patients also not fully up to expectations, be difficult to quickly alleviating pain, healing rate is slow, stays cicatrix etc. after healing.
Summary of the invention
The object of the present invention is to provide a kind of can the absorption fast, and can rebuild wound tissue, rebuild blood vessel blood fortune, promote cell regeneration, promote newly to granulate again long, and recover mucosa, damaged skin progressively is grown on the mucosa, thereby finishes the medicine for external use that epithelium is repaired.
The present invention is to provide a kind of like this skin membrane repair drug, it is characterized in that being formed by the crude drug of following mass parts:
Rhizoma Coptidis 10-20 Sanguis Draxonis 5-10
Margarita powder 10-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20
Radix Angelicae Dahuricae 5-10 Radix Arnebiae (Radix Lithospermi) 25-35
Flos Carthami 5-15
Wherein, Rhizoma Coptidis is monarch drug, energy pathogenic fire purging, detoxifcation, dampness, anti-inflammation; Margarita powder, the Pseudobulbus Bletillae (Rhizoma Bletillae) are ministerial drug, can granulation promoting put on flesh wound healing; Flos Carthami, Sanguis Draxonis are adjuvant drug, can invigorate blood circulation, dissipating blood stasis, granulation promoting, hemostasis, antifungal; The Radix Angelicae Dahuricae is for making medicine, can analgesic therapy, eliminating stagnation, evacuation of pus, and Radix Arnebiae (Radix Lithospermi) can removing heat from blood, invigorate blood circulation, heat clearing away, detoxifcation.
Skin membrane repair drug provided by the invention prepares through following method:
A, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Carthami, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi) are ground, mix, in compound, add mass concentration and be 75% medical alcohol to not having compound, flood after 24 hours, filter to get filtrate;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, behind the dipping same time, filter to get filtrate;
The filtrate of C, combining step A, B is put into filtrate to dissolving with Sanguis Draxonis, put into Margarita powder after, Recycled ethanol gets fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, gets epithelium and repairs powder;
D, step C gained epithelium is repaired powder admix in the Oleum Radix Arnebiae (Oleum Radix Lithospermi) to mastic, namely get the epithelium repairing paste.
Described Oleum Radix Arnebiae (Oleum Radix Lithospermi) obtains through following method: with after the Radix Arnebiae (Radix Lithospermi) sterilization, add the edible vegetable oil of 6 times of mass parts first, soaked 24～46 hours, filter, get Oleum Radix Arnebiae (Oleum Radix Lithospermi).
Using method:
For moist wound: sprinkle epithelium and repair powder, can prevent from oozing out, play the effect of antiinflammatory, hemostasis, granulation promoting, skin.
For the dryness wound: be coated with the epithelial membrane repairing paste, can soften the skin crust, repair as early as possible, do not stay or stay less cicatrix.
To dark II
0Burn: after using the present invention's skin membrane repair drug (use separately epithelium to repair powder or cream depending on concrete condition, perhaps unite and use epithelium to repair powder and cream), in three weeks, can recover, need not make skin graft, and preventing from scar.
Minor details are referred to the toe gangrene: after using the present invention's skin membrane repair drug (use separately epithelium to repair powder or cream depending on concrete condition, perhaps unite and use epithelium to repair powder and cream), can play controlling inflammation, promote the effect of regrowth.
Damaged and can not stitching person to bulk skin and flesh due to the huge wound: as after using the present invention's skin membrane repair drug (use separately epithelium to repair powder or cream depending on concrete condition, perhaps unite and use epithelium to repair powder and cream), can to play the effect that promotes regrowth.
The present invention has following advantages and effect: adopt such scheme, the compatibility that can improve medicine and body tissue promotes that skin can absorb the drug fully, and become an incomplete part of organizing after medicine is filled, give full play to the pathogenic fire purging of medicine, detoxifcation, dampness, invigorate blood circulation removing heat from blood, hemostasis, analgesic therapy, dissipating blood stasis, evacuation of pus, anti-inflammation, the granulation promoting effect such as put on flesh, wound healing need not made skin graft, and does not stay or stay less cicatrix, be not only applicable to burn, the epithelium reparation of scald wound, to chronic rhinitis, solar dermatitis, cheilosis, infant diaper dermatitis etc. are also applicable, and after using the present invention's skin membrane repair drug, instant therapeutic effect of healing arranged.
The specific embodiment
Below in conjunction with embodiment the present invention is described further.
Embodiment 1
Get the raw materials ready by following prescription:
10 kilograms of 10 kilograms of Sanguis Draxonis of Rhizoma Coptidis
20 kilograms of 10 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
35 kilograms of 5 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
10 kilograms on Flos Carthami
Prepare through following method:
A, 10 kilograms of Rhizoma Coptidis, 5 kilograms of Radixs Angelicae Dahuricae, 10 kilograms of Flos Carthamis, 20 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 35 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having compound, flood after 24 hours, filter to get filtrate;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, behind the dipping same time, filter to get filtrate;
The filtrate of C, combining step A, B is put into filtrate to dissolving with 10 kilograms of Sanguis Draxonis, put into 10 kilograms of Margarita powder after, Recycled ethanol gets fluid extract routinely, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, gets epithelium and repairs powder.
Embodiment 2
Get the raw materials ready by following prescription:
5 kilograms of 20 kilograms of Sanguis Draxonis of Rhizoma Coptidis
10 kilograms of 20 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
20 kilograms of 10 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
15 kilograms on Flos Carthami
Prepare through following method:
A, 20 kilograms of Rhizoma Coptidis, 10 kilograms of Radixs Angelicae Dahuricae, 15 kilograms of Flos Carthamis, 10 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having compound, flood after 24 hours, filter to get filtrate;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, behind the dipping same time, filter to get filtrate;
The filtrate of C, combining step A, B is put into filtrate to dissolving with 5 kilograms of Sanguis Draxonis, put into 20 kilograms of Margarita powder after, Recycled ethanol gets fluid extract routinely, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, gets epithelium and repairs powder.
Embodiment 3
Get the raw materials ready by following prescription:
10 kilograms of 13 kilograms of Sanguis Draxonis of Rhizoma Coptidis
15 kilograms of 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
35 kilograms of 6 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
6 kilograms on Flos Carthami
Prepare through following method:
A, 13 kilograms of Rhizoma Coptidis, 6 kilograms of Radixs Angelicae Dahuricae, 6 kilograms of Flos Carthamis, 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 35 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having compound, flood after 24 hours, filter to get filtrate;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, behind the dipping same time, filter to get filtrate;
The filtrate of C, combining step A, B is put into filtrate to dissolving with 10 kilograms of Sanguis Draxonis, put into 15 kilograms of Margarita powder after, Recycled ethanol gets fluid extract routinely, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, gets epithelium and repairs powder.
Embodiment 4
Get the raw materials ready by following prescription:
10 kilograms of 15 kilograms of Sanguis Draxonis of Rhizoma Coptidis
12 kilograms of 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
25 kilograms of 8 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
15 kilograms on Flos Carthami
Prepare through following method:
A, 15 kilograms of Rhizoma Coptidis, 8 kilograms of Radixs Angelicae Dahuricae, 15 kilograms of Flos Carthamis, 12 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having compound, flood after 24 hours, filter to get filtrate;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, behind the dipping same time, filter to get filtrate;
The filtrate of C, combining step A, B is put into filtrate to dissolving with 10 kilograms of Sanguis Draxonis, put into 15 kilograms of Margarita powder after, Recycled ethanol gets fluid extract routinely, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, gets epithelium and repairs powder;
D, step C gained epithelium is repaired powder admix in the Oleum Radix Arnebiae (Oleum Radix Lithospermi), namely get the epithelium repairing paste.
Described Oleum Radix Arnebiae (Oleum Radix Lithospermi) obtains through following method: with after 10 kilograms of Radix Arnebiae (Radix Lithospermi) sterilizations, add 60 kilograms of edible vegetable oils first, soaked 24 hours, filter, get Oleum Radix Arnebiae (Oleum Radix Lithospermi).
Rhizoma Coptidis 10-20 Sanguis Draxonis 5-10
Margarita powder 10-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20
Radix Angelicae Dahuricae 5-10 Radix Arnebiae (Radix Lithospermi) 25-35
Flos Carthami 5-15
Embodiment 5
Get the raw materials ready by following prescription:
8 kilograms of 10 kilograms of Sanguis Draxonis of Rhizoma Coptidis
15 kilograms of 17 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
30 kilograms of 10 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
10 kilograms on Flos Carthami
Prepare through following method:
A, 10 kilograms of Rhizoma Coptidis, 10 kilograms of Radixs Angelicae Dahuricae, 10 kilograms of Flos Carthamis, 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having compound, flood after 24 hours, filter to get filtrate;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, behind the dipping same time, filter to get filtrate;
The filtrate of C, combining step A, B is put into filtrate to dissolving with 8 kilograms of Sanguis Draxonis, put into 17 kilograms of Margarita powder after, Recycled ethanol gets fluid extract routinely, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, gets epithelium and repairs powder;
D, step C gained epithelium is repaired powder admix in the Oleum Radix Arnebiae (Oleum Radix Lithospermi), namely get the epithelium repairing paste.
Described Oleum Radix Arnebiae (Oleum Radix Lithospermi) obtains through following method: with after 10 kilograms of Radix Arnebiae (Radix Lithospermi) sterilizations, add 60 kilograms of edible vegetable oils first, soaked 24 hours, filter, get Oleum Radix Arnebiae (Oleum Radix Lithospermi).
For showing the present invention's effect, below by the clinical trial proved.
One, data and method
1, physical data
The burn patient is totally 120 examples, and 50 examples of wherein burning are scalded 70 examples, skin bulla, edema occur in various degree, even burned black, are diagnosed as dark II through hospital
0, wound reaches corium and muscle.120 examples are divided into two groups of matched group and treatment groups at random, and two groups of case ordinary circumstances see Table 1.
2, Therapeutic Method
Matched group uses commercial burn, soup to hinder cream, a twice-daily, sooner or later respectively once.
Treatment group is used the embodiment of the invention 3,4 skin membrane repair drug powder and ointment, a twice-daily, and each is once sooner or later.
Two groups are all used all around by the identical course for the treatment of, and stop using other medicines during treating.
3, observational technique
Observe once weekly during the medication, comprise the doing well,improving situation, untoward reaction.Treatment finished in two weeks, by special messenger's check, observed skin and improved situation.
Two, curative effect judgment criteria
1, criterion of therapeutical effect
According to the criterion of therapeutical effect of Ministry of Public Health bureau of drug administration about " guideline of clinical investigations of new drug (Chinese medicine) treatment burn and skin ".
Cure: wound healing, skin recovers normal function, and cicatrix is few and little;
Produce effects: wound healing, skin recovers basic function, and cicatrix is arranged;
Effectively: wound healing, the skin functional rehabilitation is incomplete, and cicatrix is arranged;
Invalid: wound healing, but the skin function do not recover, and cicatrix is large.
2, statistical method
Enumeration data adopts X
2The t check is adopted in check, measurement data.
Total effective rate=cure rate+obvious effective rate+effective percentage
Three, result
1, burn improvement situation sees Table 2.
2, scald the improvement situation and see Table 3.
3, untoward reaction
Treatment group patient and matched group patient all have no adverse reaction.
In addition, the present invention also has following effect:
A, wound 26 people, totally 42 fingers, wherein: from disconnected 12 fingers of hindering, weight wounds 14 fingers fully in the minor details cutting, and 13 fingers are hindered in rolloff, and 3 fingers are hindered in sawmilling, wherein keeps distal joint fully beyond the first camber line from breaking, and the fingernail finger tip all grows after the medication; Though rolloff, weight wound, full finger distortion is hindered in sawmilling, badly mutilated, the joint is broken, and phalanges ruptures but still the retainer, behind the epithelium reparation powder of the use embodiment of the invention 1, recovered former state in 2 months, and function is normal, effective percentage 100%.
B, bulk skin and flesh avulsion 20 examples, man 12 people, women 8 people, wound is large, appears humerus, two Femur blood vessels spray blood, hospitalize needs the pectoralis major flap valve to transplant, but patient's refusal, behind the skin membrane repair drug powder and medicinal ointment therapy with the embodiment of the invention 2 and 5,20 routine patients all cure, only stay a little cicatrix, the hands functional rehabilitation is good, effective percentage 100%.
C, traffic accident 22 examples are the male, and some bulk skin and flesh disappearances reach 20cm * 10cm * 1cm
3, behind the embodiment of the invention 1,4 skin membrane repair drug powder and medicinal ointment therapy, in one month, 22 routine patients' muscle covers with, and the hands functional rehabilitation is in during skin growth recovers effective percentage 100% at present.
D, chronic rhinitis 50 examples, use the embodiment of the invention 2,4 skin membrane repair drug powder and medicinal ointment therapy after, cure 20 examples fully, substantially cure 25 examples, effective percentage 90%.
Claims (1)
1. skin membrane repair drug is characterized in that being comprised of the crude drug of following mass parts:
Rhizoma Coptidis 10-20 Sanguis Draxonis 5-10
Margarita powder 10-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20
Radix Angelicae Dahuricae 5-10 Radix Arnebiae (Radix Lithospermi) 25-35
Flos Carthami 5-15.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102735579A CN102302678B (en) | 2011-09-15 | 2011-09-15 | Skin membrane repair drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102735579A CN102302678B (en) | 2011-09-15 | 2011-09-15 | Skin membrane repair drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102302678A CN102302678A (en) | 2012-01-04 |
| CN102302678B true CN102302678B (en) | 2013-01-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102735579A Active CN102302678B (en) | 2011-09-15 | 2011-09-15 | Skin membrane repair drug |
Country Status (1)
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383286A (en) * | 2014-12-08 | 2015-03-04 | 湖南科技大学 | Paste for treating burns and scalds and preparation method of paste |
| CN104547566A (en) * | 2014-12-24 | 2015-04-29 | 李永辉 | Rhinitis treating powder capable of refreshing brain, refreshing lung, relieving sore throat and alleviating pain and preparation method of powder |
| CN104644805A (en) * | 2015-01-17 | 2015-05-27 | 李秀霞 | Traditional Chinese medicine ointment and nursing method for treatment of infant red buttock |
| CN105796718A (en) * | 2016-04-10 | 2016-07-27 | 陕西省中医医院 | Skin care agent and preparation method thereof |
| CN106110022A (en) * | 2016-07-27 | 2016-11-16 | 廖全元 | A kind of burn without treating acne, scald, the medicinal liquid and preparation method thereof of wound |
| CN108853346B (en) * | 2018-09-25 | 2021-03-12 | 河南中医药大学 | External ointment for treating cheilitis |
-
2011
- 2011-09-15 CN CN2011102735579A patent/CN102302678B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 中国中医烫伤药的研究概述;王茂先;《科技资讯》;20100228(第2期);231-233 * |
| 王茂先.中国中医烫伤药的研究概述.《科技资讯》.2010,(第2期),231-233. |
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| CN102302678A (en) | 2012-01-04 |
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Effective date of registration: 20180223 Address after: 650000 Kunming, Kunming, Yunnan Province, information industry base, Yunnan sea return Venture Park, 9 2 buildings 201, 202 Patentee after: Yunnan yuncaotang Cosmetics Co., Ltd. Address before: Nanping Street 650021 Yunnan city of Kunming province No. 88 Century Square B1-11-C Patentee before: He Daming |
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