CN105853293A - Cosmetic composition with whitening effect and hand cream with whitening effect - Google Patents
Cosmetic composition with whitening effect and hand cream with whitening effect Download PDFInfo
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- CN105853293A CN105853293A CN201610329980.9A CN201610329980A CN105853293A CN 105853293 A CN105853293 A CN 105853293A CN 201610329980 A CN201610329980 A CN 201610329980A CN 105853293 A CN105853293 A CN 105853293A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a cosmetic composition with a whitening effect and hand cream with a whitening effect. The cosmetic composition comprises the following components in parts by weight: 3-8 parts of a malachite extract, 2-6 parts of a trichosanthis radix extract, 1-4 parts of a terminalia catappa leaf extract, 1-5 parts of deer bone collagen protein, 0.03-0.1 part of lecithin and 0.2-1.5 parts of hyaluronic acid. The cosmetic composition disclosed by the invention is a multi-efficacy cosmetic composition formed by compounding the malachite extract, the trichosanthis radix extract, the terminalia catappa leaf extract and the other three efficacy components according to a specific proportion; effective ingredients contained in all the efficacy components are complementary, synergistic and cooperative, are more reasonably and efficiently utilized and can better inhibit the formation of melanin and reduce pigmentation, so that the efficacy of whitening skin is achieved. The cosmetic composition with the whitening effect and the hand cream with the whitening effect disclosed by the invention can effectively moisten and nourish hand skin while having the whitening effect, effectively improve rough skin and reduce fine wrinkles and repair barbs, so that each of two hands is more delicate, smooth, well-moisturized and lustrous.
Description
Technical field
The invention belongs to cosmetic field, more particularly it relates to an have the cosmetic composition of whitening function and the hand cream containing this cosmetic composition.
Background technology
Along with the raising of people's living standard, the concern of self is got more and more by women.Beauty treatment should only not lay particular emphasis on face, cervical region, and hand is also key component.Hands is the significant points that our daily life can not leave with work, and it there will be wrinkle with advancing age.Somebody is also as physical reason occurs the situations such as dry, crackle being cold when.During life and work, hands to contact by various materials with in nature, including contacting with detergent every day and using various instrument, so skin on hand is most vulnerable to damage, such as hands is chapped, is peeled, agnail etc., agnail is one of hand and the incident disease of foot, the most occurred frequently in some special populations, such as housewife and the joyful child of nature.Deep skin can be caused to be damaged if agnail is dealt with improperly, be further development of paronychia or subungual abscess and purulence finger tip is scorching, cause harm greatly.Summer when, the sun-proof work of both hands must be handled properly, the hand cream selected preferably has sun-screening function concurrently, but sun-proof can not be inherently eliminated tanned skin, especially working clan, just through the sunlight in a summer, hand skin becomes the darkest, occupation to job requirement is high can have an impact unavoidably, and this allows working clan be very worried, this be accomplished by solve hand be dried coarse while increase white-skinned face function.Therefore, in order to beautiful and healthy, the maintenance of hand and nurse particularly significant.
Chinese patent 201510862035.0 discloses a kind of whitening hand cream, it uses Adeps Cervi 20-30 part, olive oil 20-30 part, Ovum Gallus domesticus album 5-10 part, Fructus Musae extracting solution 5-10 part, skin-whitening agents 5-10 part, lanolin oil 1-3 part, polysorbate 1-3 part, the combination of Herba Pyrolae 1-3 part to compound, and has whitening skin and preserving moisture effect.But it does not has compliance test result, there is no mechanism explanation, it is impossible to learn its real effect yet.For another example Chinese patent 201511023949.4 discloses a kind of whitening hand cream, it is made up of deionized water 50-70 part, cetearyl alcohol 2-4 part, glycerol 3-5 part, paraffin 20-30 part, dichloro-benzenes 6-8 part, sodium lauryl sulfate 2-4 part, vaseline 4-6 part, Apis cerana Fabricius 5-15 part, allantoin 5-7 part, milk 10-20 part, and it mainly reaches whitening effect by milk.But, simple dependence this composition of milk is extremely difficult to preferable whitening effect, and can not have finger agnail function concurrently simultaneously.
Summary of the invention
Based on this, in order to overcome the defect of above-mentioned prior art, the invention provides a kind of cosmetic composition with whitening function and hand cream.
In order to realize foregoing invention purpose, this invention takes techniques below scheme:
A kind of cosmetic composition with whitening function, in parts by weight, described cosmetic composition includes following components:
Malachite extract 3-7 part, extract of Trichosanthes 1-4 part, Terminalia catappa L. leaf extract 1-3 part, deer-bone collagenous albumen 1-3 part, lecithin 0.05-0.2 part, hyaluronic acid 0.05-0.15 part.
Wherein in some embodiments, described cosmetic composition includes the component of following weight portion:
Malachite extract 4-6 part, extract of Trichosanthes 2-3 part, Terminalia catappa L. leaf extract 1-2.5 part, deer-bone collagenous albumen 1.5-2.5 part, lecithin 0.1-0.15 part, hyaluronic acid 0.08-0.12 part.
Wherein in an embodiment, described cosmetic composition includes the component of following weight portion:
Malachite extract 5 parts, extract of Trichosanthes 2.5 parts, Terminalia catappa L. leaf extract 2 parts, 1.8 parts of deer-bone collagenous albumen, 0.12 part of lecithin, hyaluronic acid 0.1 part.
Present invention also offers the hand cream with whitening function, containing the above-mentioned cosmetic composition with whitening function.
Wherein in some embodiments, described hand cream is made up of the component of following percetage by weight:
Squalane 3-8%, caprylic/capric triglyceride 2-6%, cetearyl alcohol 1-4%, glyceryl stearate 1-5%, polyacrylamide/C13-14 isoparaffin/laureth-72-3%, different ceteth-the 201.8-3% of methyl gluceth-20/ isosteareth-20/, lecithin 0.1-0.15%, methyl hydroxybenzoate 0.05-0.1%, propyl hydroxybenzoate 0.05-0.1%, glycerol 4-10%, hyaluronic acid 0.05-0.15%, malachite extract 3-7%, extract of Trichosanthes 1-4%, Terminalia catappa L. leaf extract 1-3%, deer-bone collagenous albumen 1-3%, deionized water surplus.
Wherein in an embodiment, described hand cream is made up of the component of following percetage by weight:
Squalane 6%, caprylic/capric triglyceride 4%, cetearyl alcohol 3%, glyceryl stearate 3%, polyacrylamide/C13-14 isoparaffin/laureth-72.5%, the different ceteth-202.5% of methyl gluceth-20/ isosteareth-20/, lecithin 0.12%, methyl hydroxybenzoate 0.08%, propyl hydroxybenzoate 0.08%, glycerol 6%, hyaluronic acid 0.1 part, malachite extract 5%, extract of Trichosanthes 2.5%, Terminalia catappa L. leaf extract 2%, deer-bone collagenous albumen 1.8%, deionized water surplus.
The present inventor through long-felt, in many ways investigate, gathers substantial amounts of data and researches and develops, and has invented a kind of cosmetic composition with whitening function and the whitening function that has that is made up of this cosmetic composition has concurrently and prevents the hand cream of finger agnail；The formula of this cosmetic composition can reach optimal whitening effect by the proportioning of science.
Malachite stone extract of the present invention is mainly in intercellular substance by promoting the bonding between collagen protein, in addition as the generation of antioxidant activity enzyme in signal factor stimulation body, indirectly plays antioxidation and effect of scavenging radical；Extract of Trichosanthes nature and flavor hardship sweet, micro-, it is slightly cold.Tool clearing away heat and promoting production of body fluid, effect of detumescence and apocenosis；Terminalia catappa leaves nature and flavor are bitter, cool in nature, have the effect of convergence, and leaf juice has therapeutic efficiency to dermatosis, crazy and scabies.
Compared with prior art, have the advantages that
1, the cosmetic composition with whitening function of the present invention is the many effect cosmetics compositions using malachite extract, extract of Trichosanthes, Terminalia catappa L. leaf extract and other three kinds of effect components to compound formation according to specific ratio, effective ingredient contained in each effect component is complementary, collaborative, cooperation, obtain more rationally efficient utilization, can be good at suppressing melanic formation and the desalination colour of skin, thus reach effect of skin whitening.
2, cosmetic composition and the hand cream of the whitening function of the present invention has good light stability and heat stability.
3, cosmetic composition and the hand cream of the whitening function of the present invention can effectively be moistened while having whitening effect and be nourished hand skin, it is effectively improved coarse, microgroove, maintenance agnail, makes both hands feel more fine and smooth soft and smooth, present to be full of and moisten brilliance, there is significantly prevention and treatment finger agnail effect.
Detailed description of the invention
The present invention is described in detail below in conjunction with specific embodiment.In the preparation technology of following example, if no special instructions, existing conventional techniques are all used.
Malachite extract in following example is purchased from Bloomage Freda Biopharm Co., Ltd. purchased from Hua Xian bio tech ltd, Shanghai, Terminalia catappa L. leaf extract purchased from Shaanxi Sen Fu natural product company limited, deer-bone collagenous albumen purchased from Acetar Bio-tech Inc., extract of Trichosanthes.
Other raw materials or component in following example derive from commercially available.
Example 1 below-5 is the cosmetic composition with whitening function.
Embodiment 1
The cosmetic composition with whitening function includes the component of following weight portion:
Malachite extract 5 parts
Extract of Trichosanthes 2.5 parts
Terminalia catappa L. leaf extract 2 parts
1.8 parts of deer-bone collagenous albumen
0.12 part of lecithin
Hyaluronic acid 0.1 part.
Embodiment 2
The cosmetic composition with whitening function includes the component of following weight portion:
Malachite extract 7 parts
Extract of Trichosanthes 4 parts
Terminalia catappa L. leaf extract 3 parts
3 parts of deer-bone collagenous albumen
0.2 part of lecithin
Hyaluronic acid 0.15 part.
Embodiment 3
The cosmetic composition with whitening function includes the component of following weight portion:
Malachite extract 3 parts
Extract of Trichosanthes 1 part
Terminalia catappa L. leaf extract 1 part
1 part of deer-bone collagenous albumen
0.05 part of lecithin
Hyaluronic acid 0.05 part.
Embodiment 4
The cosmetic composition with whitening function includes the component of following weight portion:
Malachite extract 4 parts
Extract of Trichosanthes 2 parts
Terminalia catappa L. leaf extract 1 part
1.5 parts of deer-bone collagenous albumen
0.1 part of lecithin
Hyaluronic acid 0.08 part.
Embodiment 5
The cosmetic composition with whitening function includes the component of following weight portion:
Malachite extract 6 parts
Extract of Trichosanthes 3 parts
Terminalia catappa L. leaf extract 2.5 parts
2.5 parts of deer-bone collagenous albumen
0.15 part of lecithin
Hyaluronic acid 0.12 part.
Example 6 below-10 is the hand cream with whitening function, is calculated in mass percent in formula, is specifically shown in Table 1.
The hand cream formula with whitening function of table 1 embodiment 6-10
Whitening hand cream customary preparation methods in above-described embodiment 6-10.
The synergism of the functional component of the cosmetic composition of test example 1 present invention
For evaluating the synergism of the functional component of whitening cosmetic compound of the present invention, utilize the cosmetic composition of malachite extract, extract of Trichosanthes, Terminalia catappa L. leaf extract and embodiment 1 to carry out following melanin and generate Inhibition test.
First mouse melanin cell (Murine melanoma) (Melan-a) B16 is inoculated into the RPMI640 containing FBS or has in equal above bathmic culture medium, with every well 1 × 105Individual it is seeded on 12-well culture plate, afterwards at 5%CO2, cultivate under the conditions of 37 DEG C, until cell merges (confluent) to bottom well about 80%.Removing culture medium after cultivation, replacing with dilution (deionized water dilution) respectively has the culture medium of the cosmetic composition of the malachite extract of 1,5 and 10 μ g/ml, extract of Trichosanthes, Terminalia catappa L. leaf extract and embodiment 1, afterwards at 5%CO2, cultivate 7 at 37 DEG C.The concentration range of described sample is determined by toxicity test.The cell eliminating culture medium utilizes PBS to be carried out, and utilizes trypsin to process afterwards, reclaims cell.Reclaim the cell that obtains with 5,000-10,000rpm centrifugal treating 10 minutes, remove supernatant, obtain agglomerate (pellet).The cell mass obtained is dried at 60 DEG C, adds the 1M NaOH 100 μ l containing 10%DMSO or cell lysis buffer solution (celllysis buffer) afterwards, obtains intracellular melanin in 60 DEG C of temperature chambers.Utilize microplate reader (microplatereader) to measure under 490nm and collect liquid, utilize coomassie brilliant blue to obtain the amount of protein, obtain the melanic amount in a number of cell or the melanic amount in a number of protein afterwards.
It is as shown in table 2 that melanin after the cosmetic composition of the malachite extract of each concentration, extract of Trichosanthes, Terminalia catappa L. leaf extract and the embodiment 1 of the matched group of contrast untreated samples generates activity (%).
Table 2 melanin generates degree table
As can be known from Table 2, the cosmetic composition (i.e. malachite extract, extract of Trichosanthes, Terminalia catappa L. leaf extract and the combination of other three kinds of active component) of embodiment 1 has melanin and generates inhibition, and its effect is substantially better than the melanin generation inhibition of malachite extract, extract of Trichosanthes, Terminalia catappa L. leaf extract independent role.By the above results, the cosmetic composition of embodiment 1 has the skin whitening effects of excellence than being used alone three kinds of extracts.
The stability test of the hand cream with whitening function of test example 2 present invention
1, heat stabilization test
The hand cream to embodiment of the present invention 6-10 with whitening function carries out heat-resistance test.The hand cream of embodiment 6-10 and commercially available hand cream are concurrently placed in 50 DEG C of baking ovens and carry out heat resistant test.The results are shown in Table 3-5.
Table 3 hand cream is placed in the situation of change after one week of baking oven
| Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Commercially available product | |
| Color changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged |
| Abnormal smells from the patient changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged |
| Product is thinning | Nothing | Nothing | Nothing | Nothing | Nothing | Nothing |
Table 4 hand cream is placed in baking oven situation of change after month
| Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Commercially available product | |
| Color changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | Slightly shoal |
| Abnormal smells from the patient changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | There is abnormal flavour |
| Product is thinning | Nothing | Nothing | Nothing | Nothing | Nothing | Nothing |
Table 5 hand cream is placed in baking oven situation of change after three months
| Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Commercially available product | |
| Color changes | Unchanged | Unchanged | Unchanged | Slightly shoal | Unchanged | Slightly shoal |
| Abnormal smells from the patient changes | Unchanged | Unchanged | Unchanged | Unchanged | The most thin out | There is abnormal flavour |
| Product is thinning | Nothing | Nothing | The most thinning | Nothing | Nothing | Product is thinning |
It can be seen that the hand cream of embodiment of the present invention 6-10 is at 50 DEG C from above-mentioned table 3-5, in one month, color and abnormal smells from the patient are not changed in, and product is the most thinning.And commercially available hand cream lighter, produce abnormal flavour.Illustrate that the whitening hand cream of embodiment of the present invention 6-10 has good heat stability.
2, photo-stability testing
The hand cream to embodiment of the present invention 6-10 with whitening function carries out light fastness test.The hand cream of embodiment 6-10 and commercially available hand cream being installed with transparent packaging material is placed under sunlight, record growth product variations situation over time.The results are shown in Table 6-8.
Table 6 hand cream is placed in the situation of change after the next one week at the bottom of sunlight
| Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Commercially available product | |
| Color changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged |
| Abnormal smells from the patient changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged |
Table 7 hand cream is placed in the situation of change after next month at the bottom of sunlight
| Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Commercially available product | |
| Color changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | Shoal |
| Abnormal smells from the patient changes | Unchanged | Unchanged | Unchanged | Unchanged | Unchanged | There is abnormal flavour |
Table 8 hand cream is placed in the situation of change under sunlight after three months
| Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Commercially available product | |
| Color changes | Unchanged | Slightly shoal | Unchanged | Unchanged | Unchanged | Shoal |
| Abnormal smells from the patient changes | Unchanged | Unchanged | Unchanged | Fragrance is the most thin out | Unchanged | There is abnormal flavour |
From above-mentioned table 6-8 it can be seen that the hand cream of embodiment of the present invention 6-10 is under the direct irradiation of sunlight, in one month, color and abnormal smells from the patient are not changed in.And commercially available hand cream lighter, there is abnormal flavour.Illustrate that the whitening hand cream of the present invention has good light stability.
The melanin of the cosmetic composition of test example 3 embodiment of the present invention 1-5 generates inhibition evaluation
The test method of reference test example 1 carries out melanin and generates inhibition evaluation experimental the cosmetic composition of embodiment of the present invention 1-5.Result is as shown in table 9.
The melanin of the cosmetic composition of table 9 embodiment 1-5 generates degree table
As can be known from Table 9, the cosmetic composition of embodiment 1-5 is respectively provided with melanin and generates inhibition, and wherein the effect of the cosmetic composition of embodiment 1 is better than the cosmetic composition of other embodiments relatively.The cosmetic composition effect of embodiment 2,3 is taken second place.
The human body whitening test of the hand cream of test example 4 embodiment of the present invention 6
1, experimental subject
Select age bracket 30-50 year volunteer, man volunteer 50, female volunteer 50.Cardinal symptom: hand has freckle, the colour of skin obscure.Volunteer is divided into two groups immediately, often organizes 50 people.
2, experimental technique
Test group: after morning and evening every day face cleaning, whitening hand cream prepared by embodiment 6 is applied to hand, is massaged into absorption gently.One month experimental period.
Matched group: after morning and evening every day face cleaning, smear commercially available whitening hand cream in hand portion, be massaged into absorption gently.One month experimental period.
Any product (cosmetics or topical drug) within 2-3 days, can not be used before measuring recipient site.Before test, experimenter needs unified cleaning both hands inner forearm, by dry medicated napkin wiped clean.Measured zone labelling is carried out at experimenter's both hands inner forearm after cleaning.Should be sat quietly before official testing in standard compliant room at least 30min, and forearm exposes, and places in test mode, keeps loosening.
Right-hand man's inner forearm labelling 4 × 4cm in experiment2Pilot region, same arm can the simultaneously multiple region of labelling, interregional every 2cm.Test product (hand cream of embodiment 6) and matched group product are all randomly dispersed in left and right arm.Using dermal melanin and haemachrome tester to carry out the measurement of tested region and control zone, each region is according to parallel assay 5 times.First measure the blank value of each test zone, then by 2.0 ± 0.1mg sample/cm2Consumption, use latex finger cot sample is spread evenly across in trial zone.Smear 1 week, 2 weeks, 3 weeks, measure the dermal melanin content of tested region and white space after 4 weeks respectively.The test of same volunteer is completed by same personnel.
3, evaluation criterion
(1), dermal melanin content measured by dermal melanin and haemachrome tester.
(2), experienced by patient's readme, and computer comparison skin texture figure identifies colour of skin whitening degree and mottle desalination degree.
Effective: the colour of skin highlights, mottle color dodge.
Invalid: the colour of skin and mottle are not any change before experiment.
4, experimental result
Measure dermal melanin content results by dermal melanin and haemachrome tester to be shown in Table 10.
The average black cellulose content of table 10 test group and matched group
As can be seen from Table 10, after using embodiment 6 and commercially available hand cream, the growth the most over time of dermal melanin content and reduce, but after using the hand cream of embodiment 6 than commercially available hand cream, dermal melanin content reduces faster.Lasting and to skin the melanin minimizing of the whitening active ingredients of this explanation embodiment of the present invention 6 hand cream is worked.
Experienced by patient's readme, and computer comparison skin texture figure identifies colour of skin whitening degree and mottle desalination degree, the results are shown in Table shown in 11.
The effect table of table 11 test group and matched group
As can be known from Table 11, using 3 days, the hand cream of the embodiment of the present invention 6 just has the whitening effect being substantially better than commercially available prod, effective 38 examples of test group, effective percentage 76%, effective 12 examples of matched group, effective percentage only 24%.After using 30 days, test group effective percentage reaches 100%, and can also substantially increase the glossiness of skin, and skin exquisiteness is mellow and full, the phenomenons such as anaphylaxis, skin be uncomfortable that do not have an example to occur；And matched group effective percentage is only 60%, and there are 8 examples that the phenomenon such as anaphylaxis, skin discomfort occurs.
The finger agnail test of the hand cream of test example 5 present invention
Choose 80 30-50 year age bracket women as experimental subject, be arbitrarily divided into 8 groups, try out embodiment 6～10 and commercially available hand cream respectively, result uses grading scheme, and every using effect total score is 5 points, and 5 are divided into effect obvious, and trier is the most satisfied；4 are divided into effect preferable, and trier can accept；3 points and following be almost without effect, trier can not accept, and is below every average, and concrete outcome is shown in Table 12:
Table 12 hand cream resultant effect is investigated
In use there is not anaphylaxis and other toxic reactions in trier.
Hand agnail symptom (is dried by embodiment 6～10 hand cream and certain commercially available moisture-keeping efficacy hand cream as can be seen from the above results, red and swollen, skin lesion) all have some improvement, but the hand cream of embodiment 6～10 is substantially better than the improvement effect of certain commercially available moisture-keeping efficacy hand cream to the improvement of hand agnail symptom, the effective ingredient that thus explanation hand cream of the present invention contains: malachite extract, extract of Trichosanthes, Terminalia catappa L. leaf extract, deer-bone collagenous albumen, lecithin, there is between hyaluronic acid synergistic function, hand cream of the present invention has significantly prevention and treatment finger agnail effect.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that, for the person of ordinary skill of the art, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (6)
1. a cosmetic composition with whitening function, it is characterised in that with weight portion
Meter, described cosmetic composition includes following components:
Malachite extract 3-7 part, extract of Trichosanthes 1-4 part, Terminalia catappa L. leaf extract 1-3
Part, deer-bone collagenous albumen 1-3 part, lecithin 0.05-0.2 part, hyaluronic acid 0.05-0.15 part.
The cosmetic composition with whitening function the most according to claim 1, it is special
Levying and be, described cosmetic composition includes the component of following weight portion:
Malachite extract 4-6 part, extract of Trichosanthes 2-3 part, Terminalia catappa L. leaf extract 1-2.5
Part, deer-bone collagenous albumen 1.5-2.5 part, lecithin 0.1-0.15 part, hyaluronic acid 0.08-0.12
Part.
The cosmetic composition with whitening function the most according to claim 2, it is special
Levying and be, described cosmetic composition includes the component of following weight portion:
Malachite extract 5 parts, extract of Trichosanthes 2.5 parts, Terminalia catappa L. leaf extract 2 parts,
1.8 parts of deer-bone collagenous albumen, 0.12 part of lecithin, hyaluronic acid 0.1 part.
4. a hand cream with whitening function, it is characterised in that contain in described hand cream
Have the right the cosmetic composition with whitening function described in requirement any one of 1-3.
The hand cream with whitening function the most according to claim 4, it is characterised in that
Described hand cream is made up of the component of following percetage by weight:
Squalane 3-8%, caprylic/capric triglyceride 2-6%, cetearyl alcohol 1-4%, sweet
Oleostearin acid esters 1-5%, polyacrylamide/C13-14 isoparaffin/laureth-72-3%,
Different ceteth-the 201.8-3% of methyl gluceth-20/ isosteareth-20/, ovum phosphorus
Fat 0.1-0.15%, methyl hydroxybenzoate 0.05-0.1%, propyl hydroxybenzoate 0.05-0.1%, glycerol 4-10%,
Hyaluronic acid 0.05-0.15%, malachite extract 3-7%, extract of Trichosanthes 1-4%, olive
Core leaf extract 1-3%, deer-bone collagenous albumen 1-3%, deionized water surplus.
The hand cream with whitening function the most according to claim 5, it is characterised in that
Described hand cream is made up of the component of following percetage by weight:
Squalane 6%, caprylic/capric triglyceride 4%, cetearyl alcohol 3%, glyceryl stearate
Acid esters 3%, polyacrylamide/C13-14 isoparaffin/laureth-72.5%, methyl Portugal
The different ceteth-202.5% of sugar alcohol polyethers-20/ isosteareth-20/, lecithin 0.12%,
Methyl hydroxybenzoate 0.08%, propyl hydroxybenzoate 0.08%, glycerol 6%, hyaluronic acid 0.1 part, peafowl
Stone extract 5%, extract of Trichosanthes 2.5%, Terminalia catappa L. leaf extract 2%, deer-bone collagenous
Albumen 1.8%, deionized water surplus.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108498347A (en) * | 2018-05-16 | 2018-09-07 | 江西登云健康美业互联有限公司 | A kind of malachite mildy wash and preparation method thereof |
| CN108524324A (en) * | 2018-05-16 | 2018-09-14 | 江西登云健康美业互联有限公司 | A kind of protection cream and preparation method thereof |
| CN108653123A (en) * | 2018-03-30 | 2018-10-16 | 广东巴松那生物科技有限公司 | A kind of face cream and preparation method thereof containing ore energy and liquid platinum |
| CN111388342A (en) * | 2020-05-30 | 2020-07-10 | 宁夏厚泽生物医药科技有限公司 | Natural component for removing melanin and application thereof in removing freckles and whitening |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103830152A (en) * | 2014-03-14 | 2014-06-04 | 集安五味堂生物科技有限公司 | Cosmetic composition and essence with skin whitening function |
| CN104027296A (en) * | 2014-06-12 | 2014-09-10 | 贵州普济生物技术有限公司 | Whitening cleanser and preparation method thereof |
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- 2016-05-18 CN CN201610329980.9A patent/CN105853293A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830152A (en) * | 2014-03-14 | 2014-06-04 | 集安五味堂生物科技有限公司 | Cosmetic composition and essence with skin whitening function |
| CN104027296A (en) * | 2014-06-12 | 2014-09-10 | 贵州普济生物技术有限公司 | Whitening cleanser and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108653123A (en) * | 2018-03-30 | 2018-10-16 | 广东巴松那生物科技有限公司 | A kind of face cream and preparation method thereof containing ore energy and liquid platinum |
| CN108498347A (en) * | 2018-05-16 | 2018-09-07 | 江西登云健康美业互联有限公司 | A kind of malachite mildy wash and preparation method thereof |
| CN108524324A (en) * | 2018-05-16 | 2018-09-14 | 江西登云健康美业互联有限公司 | A kind of protection cream and preparation method thereof |
| CN111388342A (en) * | 2020-05-30 | 2020-07-10 | 宁夏厚泽生物医药科技有限公司 | Natural component for removing melanin and application thereof in removing freckles and whitening |
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