CN105687055B - A kind of eye maintenance Essence and preparation method thereof - Google Patents
A kind of eye maintenance Essence and preparation method thereof Download PDFInfo
- Publication number
- CN105687055B CN105687055B CN201610172744.0A CN201610172744A CN105687055B CN 105687055 B CN105687055 B CN 105687055B CN 201610172744 A CN201610172744 A CN 201610172744A CN 105687055 B CN105687055 B CN 105687055B
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- Prior art keywords
- eye
- extract
- skin
- essence
- butanediol
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- 238000012423 maintenance Methods 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims description 7
- 239000000203 mixture Substances 0.000 claims abstract description 25
- 230000000694 effects Effects 0.000 claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 11
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 10
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 9
- 241000196324 Embryophyta Species 0.000 claims abstract description 9
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 9
- 229960001631 carbomer Drugs 0.000 claims abstract description 9
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 8
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 8
- 235000021317 phosphate Nutrition 0.000 claims abstract description 8
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims abstract description 8
- 229920002643 polyglutamic acid Polymers 0.000 claims abstract description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 8
- 241000219357 Cactaceae Species 0.000 claims abstract description 7
- 102000012479 Serine Proteases Human genes 0.000 claims abstract description 7
- 108010022999 Serine Proteases Proteins 0.000 claims abstract description 7
- 229960003237 betaine Drugs 0.000 claims abstract description 6
- 150000002191 fatty alcohols Chemical class 0.000 claims abstract description 6
- 235000011187 glycerol Nutrition 0.000 claims abstract description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 6
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000458 allantoin Drugs 0.000 claims abstract description 5
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 5
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 4
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 4
- 229920000193 polymethacrylate Polymers 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 241000212297 Pelvetia Species 0.000 claims description 5
- 230000007062 hydrolysis Effects 0.000 claims description 5
- 238000006460 hydrolysis reaction Methods 0.000 claims description 5
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 4
- 241000050051 Chelone glabra Species 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- -1 glycerine Olefin Chemical class 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 241000978776 Senegalia senegal Species 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 239000013589 supplement Substances 0.000 abstract description 4
- 229940068918 polyethylene glycol 400 Drugs 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 38
- 239000000686 essence Substances 0.000 description 29
- 238000012360 testing method Methods 0.000 description 18
- 230000003020 moisturizing effect Effects 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 229930003448 Vitamin K Natural products 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 4
- 235000019168 vitamin K Nutrition 0.000 description 4
- 239000011712 vitamin K Substances 0.000 description 4
- 150000003721 vitamin K derivatives Chemical class 0.000 description 4
- 229940046010 vitamin k Drugs 0.000 description 4
- 239000006071 cream Substances 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
- 206010012442 Dermatitis contact Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 241000206572 Rhodophyta Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 208000010247 contact dermatitis Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010052139 Eye oedema Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 244000221569 Opuntia streptacantha Species 0.000 description 1
- 235000000771 Opuntia streptacantha Nutrition 0.000 description 1
- 241000206754 Palmaria palmata Species 0.000 description 1
- 241001262104 Pelvetia canaliculata Species 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
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- 229920001971 elastomer Polymers 0.000 description 1
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- 238000004945 emulsification Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
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- 210000000245 forearm Anatomy 0.000 description 1
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- 229940069016 go-dry Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
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- 230000035807 sensation Effects 0.000 description 1
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- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a kind of eye maintenance Essence, it includes the fatty alcohols of 22 phosphates of C20/C20 22, allantoin, glycine betaine, butanediol, glycerine polymethacrylates, Carbomer, polyglutamic acid, Sodium Hyaluronate, polyethylene glycol 400, and the Multiple components such as Cactus Pedicel extract are pierced in triethanolamine, beta glucan, palmityl tripeptides 5, serine proteinase activities composition, plant Shu Min agent, torsion.The present invention can effectively supplement eye skin moisture, moisten eye skin, desalinate the microgroove and livid ring around eye of eye.
Description
Technical field
The invention belongs to cosmetic technical field, particularly a kind of eye maintenance Essence, and the eye maintenance
The preparation method of Essence.
Background technology
Eye skin is human body skin most thin position, and the thickness summation of eye epidermis and corium is about just 0.55 millimeter,
Only 1/3 to 1/5 thickness of face skin, eye subcutaneously almost no sebaceous glands sweat gland distribution, thin thin skin skin near the eyes is very
Easily dry, because almost without ability is automatically moistened, the grease that can be supplied is considerably less, contained collagen, elastic force egg
It is white less.In addition, circumocular skin also very sensitive, fragility, capilary is extremely fine.
Blink can be more than 10,000 times daily by people, that is to say, that under normal conditions, people to blink 15 times, eye per minute
The motion of high intensity is along with the influence of outside factors, such as ultraviolet and computer radiation, bad life habits, pollution, coloured silk
The phenomenons such as various expression lines, age line, relaxation, edema, livid ring around eye generally occur in many grievous hurts of adornment, eye skin, make female
Property look and present a weathered appearance, without spirit.Therefore, the nursing of eye skin is highly important.
Eye-care product are primarily to reaching that eye replenishing water and preserving moisture, eye are crease-resistant, removing smooth cut, go dry line, eye lifting
The effects such as compacting, go edema, go livid ring around eye.At present, eyeware products and solution for lenses and contact lenses on the market mainly has eye cream, eye glue and eye mask three big
Class.Eye cream is rich in a variety of oils and nutriment, and moistness is strong, and improper use is most also easy to produce fat granule；Eye glue is a kind of plant
Property gel shape material, composition be gently easier to absorb.Eye skin first typically is smeared with Essence, eye cream or eye glue is reused.Cause
This, it is highly important to select a efficiently comprehensive Essence.
Eyeware products and solution for lenses and contact lenses at present on the market is a lot, but using effect is not obvious, or excitant is higher, it is impossible to reach
Safe and efficient effect.Therefore, it is very necessary to develop a safe and effective, gentle inirritative eye essence.
The content of the invention
It is contemplated that the technical problem to be solved for more than is not stimulated safely and effectively, gently there is provided one kind, raw material
Natural green, can effectively supplement eye skin moisture, reduce wrinkle and microgroove, the eye maintenance Essence of Vitamin K.
Present invention also offers the preparation method of the eye maintenance Essence.
In order to realize the above object the invention provides following technical scheme：
A kind of eye maintenance Essence, it is consisted of the following components in percentage by weight：C20-22 phosphates/C20-22 fat
Fat alcohol 0.3-0.8%, allantoin 0.1-0.4%, glycine betaine 0.5-4%, butanediol 3-8%, glycerine polymethacrylates
0.5-3%, Carbomer 0.12-0.22%, polyglutamic acid 0.03-0.15%, Sodium Hyaluronate 0.01-0.1%, polyethylene glycol-
400 1-5%, triethanolamine 0.2-0.28%, beta glucan 1-6%, the 1-6% of palmityl tripeptides -5, serine proteinase activities composition
0.5-4%, plant Shu Min agent 0.4-2%, turn round thorn Cactus Pedicel extract 0.5-4%, hydrolyze avenin 1-5%, slap leaf tree
Extract 1-5%, ditch pelvetia silquosa extract 1-4%, Phenoxyethanol/Sensiva SC50 0.5-0.6%, deionized water surplus.
Present invention also offers the preparation method of the eye maintenance Essence, its step is as follows：
(1) while stirring, Sodium Hyaluronate and polyglutamic acid is slowly added in PEG-4000, are sufficiently stirred for
To being uniformly dispersed, 5%-10% deionized water is added, it is transparent without graininess to stir to solution, obtains first
Mixture；
(2) it is triethanolamine is scattered in advance with the deionized water that the Essence total weight percent is 2% is accounted for, obtain
Second mixture；
(3) by C20-22 phosphates/C20-22 fatty alcohols, allantoin, glycine betaine, butanediol, glycerine polymethylacrylic acid
Ester, Carbomer and the mixing of remaining deionized water, are heated with stirring to 80-85 DEG C, homogeneous, and insulated and stirred to C20-22 phosphates/
C20-22 fatty alcohols and Carbomer are completely dissolved, and obtain the 3rd mixture, and second mixture is added to the described 3rd and mixed
In compound, pH is to 6-7 for regulation, starts cooling；
(3) 45 DEG C are cooled to, first mixture is added, cooled after stirring, during to 40 DEG C, β-Portugal is added and gathers
Sugar, palmityl tripeptides -5, serine proteinase activities composition, plant Shu Min agent, torsion thorn Cactus Pedicel extract, hydrolysis avenin, the palm
Leaf tree extract, ditch pelvetia silquosa extract and Phenoxyethanol/Sensiva SC50, stir, and produce eye maintenance Essence.
It is worth noting that, " Phenoxyethanol/Sensiva SC50 " of the present invention is known in the art cosmetic material,
Those skilled in the art, which can understand, determines that it is constituted.Preferably, the part by weight of Phenoxyethanol and Sensiva SC50 is 9:1.
In the eye maintenance Essence of the present invention, the complementary synergistic component of a variety of reasonable mixture ratios is used, has effectively been carried
High effect performance of the eye maintenance Essence of the present invention.
Water can be adsorbed by adding PEG-4000, butanediol, glycine betaine etc. in the eye maintenance Essence of the present invention simultaneously
The NMF divided, (its INCI is entitled for polyglutamic acid, glycerine polymethacrylates, Sodium Hyaluronate, serine proteinase activities composition
" water/butanediol/mosanom/serine/Carbomer/gum arabic/methyl hydroxybenzoate ", English trade name Moisturizing
Vegetal MICROPATCH, are purchased from BASF AG) etc. there is the NMF of deep layer water lock moisture-keeping efficacy, and β-Portugal is poly-
Sugar, hydrolysis avenin etc. have the deep moisturizing agent for repairing barrier function.There is efficient deep layer after these NMFs compounding
Moisturizing water lock effect, can assign skin and moisten smooth sense of touch；Skin cell metabolism can also be promoted simultaneously, improve the battalion of skin
Metabolism and physiological condition are supported, promotes the synthesis of collagen and elastomer, increases skin elasticity, effective maintenance eye skin.
Present invention adds palmityl tripeptides -5, it possesses the small molecule tripeptides of unique sequence, simulates the machine of human body itself
System generates collagen by TGF-β, while protecting collagen by suppressing MMP (matrix metalloproteinase) from drop
Solution.Both Synergistics, reach the maximization of anti-wrinkle effect, improve skin turgor, reduce wrinkle and microgroove, make eye skin
Rejuvenate.
The hydrolysis avenin that the present invention is used is a kind of from avenin compound, and it adds the present invention, with bright
The aobvious effect compacted immediately, can make skin produce instantaneous tight sensation, at the same also have concurrently moisturizing, film forming, anti-aging and
The effect of glabrous skin.Hydrolysis avenin is arranged in pairs or groups high molecular polyglutamic acid and Sodium Hyaluronate again, can be in circumference of eyes flesh
Skin one layer of smooth film of formation, such as second layer skin, can reduce the injury of outside contamination and other factors to eye skin, and
Can deep moisturizing moisturizing, the drying relaxed condition of reduction eye skin, eye skin of compacting.
The present invention also added palm leaf tree (Palmaria palmata) extract, and (" red algae microcirculation promotees its trade name
Enter the factor ", it is purchased from Guangzhou Nuo Ran biotech inc), extract from Atlantic Ocean northeast and the northwestward and ground
Middle sea is grown on the natural red algae elite of iron bound shore, can greatly enhance microcirculation system, enhance metabolism, rapid to exclude
Excessive moisture and the toxin and waste for accumulating in eye, prevent accumulation of the fat cell in capilary, are effectively improved pouch
Repair livid ring around eye；Also there are extremely strong antipollution, Green Tea Extract effect simultaneously, the skin caused by drying with ultraviolet can be effectively improved
Skin is coarse, aging phenomenon.In addition, ditch pelvetia silquosa (Pelvetia canaliculata) extract of addition, can accelerate eye flesh
Skin metabolism, suppresses melanin and is formed, emphasis Vitamin K, at the same can effective maintenance skin cell, consolidate eye texture
Tissue, the problem of improving low and deep and eye edema keeps eye skin brilliance careful, makes bright eyes glittering charming.
The present invention also added plant Shu Min agent and turns round thorn Cactus Pedicel extract simultaneously.Plant Shu Min agent (INCI titles
For " water/butanediol/kuh-seng root extract/swollen fruit Radix root extract/root of large-flowered skullcap root extract ", the limited public affairs of Shanghai character used in proper names and in rendering some foreign names leaf are purchased from
Department) contain kuh-seng, Radix Glycyrrhizae and the classical anti-inflammatory anti-anaphylaxis vegetable active composition of three kinds of the root of large-flowered skullcap；Turn round thorn cactus (Opuntia
Streptacantha) stem extraction is rich in various active compositions such as sterol, flavones, polyphenol.Both compoundings, with excellent thin
Born of the same parents releive function, have significant repair to general chemical stimulant, UV-induced cellular damage etc. in cosmetics,
The phenomenons such as the common general red, itch of sensitive skin can substantially be slowed down, the sensitivity level of eye skin is reduced.
Test effect shows, compared with prior art, eye maintenance elite of the invention, rich in various plants extract,
Moisturizing water lock composition, crease-resistant relaxing factor etc., effectively can supplement and keep eye skin moisture, reduce wrinkle and microgroove,
Vitamin K etc., effective maintenance eye skin.
Brief description of the drawings
Fig. 1 is the hydroscopicity situation about changing over time of the eye maintenance Essence of the present invention.
Fig. 2 is the moisture content of skin test result of the eye maintenance Essence of the present invention.
Embodiment
Technical scheme is described in further detail with reference to specific embodiment, but the invention is not restricted to following
Embodiment.It is worth noting that, unless otherwise indicated, various components used in the present invention are this area current material, can
Bought by commercial channel and obtain or be made by existing method.
Specific embodiment is as shown in table 1.
Table 1
The preparation technology of above example is as follows：
(1) the second phase is prepared：While stirring, Sodium Hyaluronate and polyglutamic acid are slowly added to PEG-4000
In, it is stirred well to and is uniformly dispersed, adds 5%-10% (based on the deionized water gross weight in this formula) deionized water, fill
Divide and be evenly stirred until that solution is transparent without graininess；
(2) the first phase raw material is added in emulsification pot, be stirred and heated to 80-85 DEG C, appropriate homogeneous, insulated and stirred is extremely
C20-22 phosphates/C20-22 fatty alcohols and Carbomer are completely dissolved, and add pre-dispersed good third phase, pH is to 6-7 for regulation, opens
Begin to cool；
(3) 45 DEG C are cooled to, the second phase pre-processed is added, cooled after stirring, at 40 DEG C, the 4th phase is added,
Stir, produce eye maintenance Essence.
The hydroscopicity of test example 1 is tested
1st, test method：Each 2 parts of 6g eye maintenance Essences in embodiment 1-3 are weighed respectively, are placed in a diameter of 4cm's
In measuring cup, at room temperature, 8h is placed in relative humidity is 43%, 75% environment respectively, in 1h, 2h, 4h, 6h, 8h difference
Weighed, and record the change of sample quality, calculated hydroscopicity, three Duplicate Samples are done every time, are averaged.
Hydroscopicity=[(mi-m0)/m0] * 100%
Wherein miFor the sample quality of i-th hour, g；m0For sample quality, g before experiment.
2nd, result of the test：The situation that the hydroscopicity of eye maintenance Essence is changed over time is shown in Fig. 1.By that can be seen in figure
Go out, hydroscopicity is negative value, this show sample placed through the long period after moisture can all scatter and disappear, but at room temperature, relatively wet
Placed in the environment of degree respectively 43% and 75% after 8h, average hydroscopicity highest is respectively -1.75% and -1.24%, dehydration
Slowly, illustrate that the eye maintenance Essence has preferable moisturizing power.
The moisture content of skin of test example 2 is tested
1st, test method
1.1 look for 30 subjects, and women, the age is interior at 25-45 Sui.
1.2 select the left and right arms of subject cycle labeling successively：Tested region samples group (any embodiment system of the present invention
The eye skin care item obtained) and blank control region；
1.3 technical staff measure tested region and blank control region respectively using skinanalysis apparatus MPA 6, are averaged
Value, is designated as initial value.
1.4 Test sites cleaned in subject through clear water smear submitted sample, and blank control region is not smeared any
Sample.
1.5 subjects are after continuously using test sample 0.5h, 1h, 2h, 4h, 6h, by technical staff using using skin
Tester MPA 6 measures tested region and blank control region 5 times respectively, averages.
The numerical value that 1.6 statistics are measured, analyzes its moisture content of skin changing rule
2nd, result of the test：
Test result is as shown in Figure 2.As seen from Figure 2, recipient site is smeared after sample 0.5h, recipient site it is aqueous
Significantly raised (the p of amount<0.05), within 6 hours of test, moisture is all the time apparently higher than control group (p<0.05), and
After the 4h of test, moisture declines slowly, and illustrating the eye maintenance Essence of the embodiment of the present invention 1~3 has good guarantor
Wet water lock effect.
The human body patch of test example 3 is tested
1st, test method：Subject amounts to 30 people, and specific sex composition and age composition determine (to meet at random《Cosmetics
Contact dermatitis diagnostic criteria and treatment principle》Include, exclusion standard).Sample made from embodiment 1,2,3 is put into spot examination device
Interior (amount of samples is 0.020~0.025g), control wells are blank (not putting any material), and sample and blank control are affixed on
The bent side of the forearm of subject, is gently pressed with palm and is allowed to equably be pasted on skin, continue 24h.30min after spot examination device is removed,
Dermoreaction is observed after impression disappears.Such as result is feminine gender, is observed again once respectively in 24h and 48h.
According to《Cosmetics contact dermatitis diagnostic criteria and treatment principle》, its classify judge standard it is as shown in table 2.
Table 2
2nd, result of the test：Embodiment of the present invention 1-3 human body patch test results are as shown in table 3.
Table 3
Test result indicate that, for embodiment 1-3 eye maintenance Essence, 30 this time tested people show as feminine gender
Reaction, illustrates that the eye maintenance Essence of the present invention has no adverse reaction to human body skin.
The skin of test example 4 tries out test for a long time
80 women are chosen, are divided into four groups, embodiment 1,2,3 and commercially available eye essence are tried out respectively, testing crew is every
Appropriate eye essence is evenly coated in circumference of eyes by it sooner or later, continuous to smear 60 days.Result on trial is as shown in table 4.
Table 4
Result on trial shows that, for embodiments of the invention 1-3, its effective percentage for moistening moisturizing is 85%-90%, desalination
The effective percentage of microgroove is 78%-83%, and the effective percentage of Vitamin K is 73%-80%, is above commercially available eye essence
Effective percentage, this shows that the eye maintenance Essence of the present invention more efficient can supplement eye skin moisture, moistens eye skin,
Desalinate microgroove and livid ring around eye etc. of eye, than commercially available eye essence more can effective maintenance eye skin various problems.
Claims (2)
1. a kind of eye maintenance Essence, it is characterised in that consist of the following components in percentage by weight：C20-22 phosphates/
C20-22 fatty alcohol 0.3-0.8%, allantoin 0.1-0.4%, glycine betaine 0.5-4%, butanediol 3-8%, the poly- methyl-prop of glycerine
Olefin(e) acid ester 0.5-3%, Carbomer 0.12-0.22%, polyglutamic acid 0.03-0.15%, Sodium Hyaluronate 0.01-0.1%, poly- second
The 1-5% of glycol -400, triethanolamine 0.2-0.28%, beta glucan 1-6%, the 1-6% of palmityl tripeptides -5, serine proteinase activities
Composition 0.5-4%, plant Shu Min agent 0.4-2%, turn round thorn Cactus Pedicel extract 0.5-4%, hydrolyze avenin 1-5%, the palm
Leaf tree extract 1-5%, ditch pelvetia silquosa extract 1-4%, Phenoxyethanol/Sensiva SC50 0.5-0.6%, more than deionized water
Amount；Wherein, in the Phenoxyethanol/Sensiva SC50, the part by weight of Phenoxyethanol and Sensiva SC50 is 9:1；Institute
Serine proteinase activities composition is stated for water/butanediol/mosanom/serine/Carbomer/gum arabic/methyl hydroxybenzoate；The plant
Shu Min agent is water/butanediol/kuh-seng root extract/swollen fruit Radix root extract/root of large-flowered skullcap root extract.
2. the preparation method of eye maintenance Essence described in claim 1, it is characterised in that step is as follows：
(1) while stirring, Sodium Hyaluronate and polyglutamic acid is slowly added in PEG-4000, are stirred well to point
Dissipate uniform, add 5%~10% deionized water, it is transparent without graininess to stir to solution, obtain first and mix
Compound；
(2) it is triethanolamine is scattered in advance with the deionized water that the Essence total weight percent is 2% is accounted for, obtain second
Mixture；
(3) by C20-22 phosphates/C20-22 fatty alcohols, allantoin, glycine betaine, butanediol, glycerine polymethacrylates, card
Ripple nurse and remaining deionized water mixing, are heated with stirring to 80-85 DEG C, homogeneous, insulated and stirred to C20-22 phosphates/C20-22 fat
Fat alcohol and Carbomer are completely dissolved, and obtain the 3rd mixture, and second mixture is added into the 3rd mixture, are adjusted
PH is saved to 6-7, starts cooling；
(3) 45 DEG C are cooled to, first mixture is added, cooled after stirring, during to 40 DEG C, beta glucan, palm fibre is added
Palmitic acid acyl tripeptides -5, serine proteinase activities composition, plant Shu Min agent, torsion thorn Cactus Pedicel extract, hydrolysis avenin, palm Ye Shuti
Thing, ditch pelvetia silquosa extract and Phenoxyethanol/Sensiva SC50 are taken, is stirred, eye maintenance Essence is produced.
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| CN108186519A (en) * | 2018-02-13 | 2018-06-22 | 卢玉香 | cassia seed eye essence and preparation method thereof |
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| CN111012711B (en) * | 2019-12-30 | 2022-07-12 | 暨南大学 | A composition with skin repairing and anti-aging effect and skin care product thereof |
| CN113425642B (en) * | 2021-07-12 | 2022-07-29 | 广州市南方医康生物科技有限公司 | Eye care composition |
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| CN102078271B (en) * | 2010-11-26 | 2012-07-04 | 新时代健康产业（集团）有限公司 | Skin care composition with moisturizing efficacy and preparation and preparation method thereof |
| CN102860961B (en) * | 2012-09-24 | 2014-01-22 | 彭再辉 | Eye pad essence containing peony root extracts and preparation method for eye pad essence |
| CN104382833B (en) * | 2014-10-28 | 2015-11-18 | 广东碧嫄化妆品有限公司 | Plant protein peptide stock solution and its preparation method and application |
| CN105078852A (en) * | 2015-09-27 | 2015-11-25 | 龚灿锋 | Whitening cosmetic emulsion containing plant extractives |
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