CN105168360A - Compound plant extract liniment for treating acne and preparation method of compound plant extract liniment - Google Patents

Abstract

The invention discloses a plant extract compound liniment for treating acne and acne and a preparation method thereof. Made from raw materials. The preparation is especially suitable for treating stubborn acne, scabies and impetigo, and has the effects of eliminating acne, shrinking pores, removing mites, and delicate skin.

Description

A plant extract compound liniment for treating acne and acne and its preparation method

technical field

The invention discloses a plant extract compound liniment for treating acne and acne, and also provides a preparation method thereof, belonging to the technical field of medicine and pharmacy.

Background technique

Acne is a chronic inflammatory disease of hair follicles and sebaceous glands related to various factors such as genetics, endocrine, infection, and immune abnormalities. It often occurs in seborrhea, including the head, face, chest and back, and is a common disease in cosmetic dermatology. . According to statistics, the incidence rate of acne among teenagers is about 90%.

At present, most of the medicines for treating acne and acne sold on the market are chemically synthesized, the active ingredients are very unstable, contain hormones in different degrees, and the human body has large side effects after use, and it is easy to relapse (such as: Dactin, 999 Dermatitis, etc.), Long-term or excessive use will affect the liver and kidney of the human body, which not only brings pain to the patient mentally, but also brings a great burden economically. The invention of Chinese patent No. CN102335287A discloses a mixture capable of removing acne and acne marks. It is mainly composed of rosehip oil, tea tree oil, salicylic acid and citric acid as main raw materials, and is processed by adding a certain amount of auxiliary materials or matrix. Come. This product can treat acne, acne, and acne, and can accelerate skin metabolism, effectively remove acne spots and acne marks, and make the skin smooth and bright. However, long-term use of chemical liquid medicine is easy to cause great side effects to patients. The invention of Chinese patent No. CN103655382A discloses a compound essential oil for acne pigmentation, which is mainly composed of cedar oil, rosemary essential oil, geranium essential oil, lavender essential oil, carrot seed essential oil, jojoba base oil, and has a balanced Skin oil, promotes skin metabolism, and effectively eliminates acne skin pigmentation. The compound liniment of the present invention can not only eliminate acne skin pigmentation, but also has anti-inflammatory, granulation-promoting, and cell regeneration effects, and has a better effect in treating acne and acne.

Contents of the invention

The invention provides a plant extract compound liniment for treating acne and acne and a preparation method thereof. The plant volatile oil in the preparation is non-irritating, conforms to the chemical properties of the skin, and is beneficial to the play of the physiological functions of the skin. It also has skin care effect, and at the same time, it has a particularly good effect of anti-inflammatory, antibacterial, and muscle-building.

A plant extract compound liniment for treating acne and acne of the present invention is characterized in that it is made of the following medicines in parts by weight:

Lavender essential oil 10-30, tea tree oil 5-25, cedar oil 2-5, mugwort oil 0.8-2, star anise oil 0.5-1.2, cinnamon oil 0.5-2, liquid paraffin 60-100, menthol 18-40,

A plant extract compound liniment for treating acne and acne of the present invention, its preferred proportioning by weight is:

Lavender essential oil 25, tea tree oil 20, cedar oil 5, mugwort oil 2, star anise essential oil 1, cinnamon oil 0.5, liquid paraffin 100, menthol 40.

A preparation method of a plant extract compound liniment for treating acne and acne disclosed by the present invention comprises the following steps:

First dissolve menthol and liquid paraffin in a water bath, then add cinnamon oil and stir on a magnetic stirrer, then add lavender essential oil, tea tree oil, cedar oil, mugwort oil, star anise oil in proportion and continue stirring until clear Transparent, instant product.

The plant extract compound liniment for treating acne and acne of the present invention is characterized in that: the stirring temperature is 20-40°C, the stirring speed is 30-60 rpm, and the stirring time is 1-4 hours.

The plant extract compound liniment for treating acne and pimples of the present invention is characterized in that the preferred stirring temperature is 25° C., the stirring speed is 30 revolutions/minute, and the stirring time is 2 hours.

The plant extract compound liniment for treating acne and acne of the present invention is characterized in that the composition can be made into gel, ointment, spray, lotion, suppository, etc. by adding other auxiliary materials such as solubilizer or non-aqueous solvent. Various disinfection products such as disinfectants for skin and mucous membranes, disinfectant wipes, sterile gauze, band-aids, etc., can also be used in different forms or purposes such as hygiene and daily chemical products.

Among the medicines used in the present invention, tea tree oil: has a strong antiviral effect, can promote wound healing, treat skin wounds, burns; personal care products currently on the market such as hair care, body care, footwash, soap, Antibacterial footwashes, breath fresheners and oral care products all contain tea tree oil as the main active ingredient. Lavender essential oil: can effectively improve burns, sunburn, eczema, psoriasis, abscessed skin, improve scars, inhibit bacterial growth, and help hair growth. Modern medical research shows that lavender essential oil can also promote cell regeneration and balance oil secretion. Cedarwood oil: anti-inflammatory, antibacterial, astringent (beneficial to oily skin, improving acne and acne skin, helping to eliminate scabs, pus, and some chronic diseases, such as eczema and psoriasis), diuretic, softening phlegm, killing fungi; on acne And acne have disinfection effect. Promote the growth of skin cells, assist in the treatment of acne, pimples and eczema. Artemisia argyi oil: antibacterial, antiviral, antiallergic, hemostatic and anticoagulant, enhances immune function, protects liver and gallbladder, relieves heat and calms, inhibits heart contraction, and also has certain expectorant and antitussive effects. Star anise oil: antibacterial (Gram-positive bacteria: Staphylococcus aureus, pneumococcus, diphtheria bacillus, Gram-negative bacteria: Escherichia coli, Bacillus subtilis, Vibrio cholerae and typhoid bacillus, paratyphoid bacillus, Shigella) , Antioxidant, analgesic and insecticidal effects. Cinnamon oil: It is a spice, which has the effects of aroma, invigorating the stomach, and expelling wind. It can be used to treat rheumatism and skin itching, the same as cinnamon oil. In the compound liniment prepared by mixing the above components, the active ingredients can be concentrated to produce synergistic effect, which makes up for the defect of poor curative effect of a single component.

The positive effects of the present invention are:

1. Compared with other products in the field of disinfection and sterilization, it has the characteristics of natural medicines, has definite curative effect, and does not have many adverse effects and side effects of chemicals. 2. Compared with similar products of traditional Chinese medicine extracts, it has no bad smell and appearance. 3. Simple and convenient to use, good skin permeability, non-irritating, not easy to residue, and does not need to be used in conjunction with other drugs. 4. It conforms to the chemical properties of the skin and is conducive to the play of the physiological functions of the skin. It has both therapeutic and skin care effects, and at the same time has a particularly good effect of anti-inflammatory, antibacterial, and muscle-generating.

Detailed ways

The following examples help those skilled in the art to better understand the present invention, but do not limit the present invention in any way.

The present invention will be further elaborated below in conjunction with specific embodiment

Example 1

Dissolve 40g of menthol and 100g of liquid paraffin in a water bath at 40°C, place it on a magnetic stirrer with a rotation speed of 30r/min and a temperature of 25°C, then slowly add 0.5g of cinnamon oil and stir for 2 hours, then add 25g of lavender The essential oil, 20g of tea tree oil and 5g of cedarwood oil were stirred for 2 hours, and finally 2g of mugwort leaf oil and 1g of star anise oil were slowly added in sequence, and the stirring was continued until it was clear and transparent, and the finished product was obtained.

Example 2

Dissolve 30g of menthol and 85g of liquid paraffin in a 40°C water bath, place it on a magnetic stirrer with a rotation speed of 50r/min and a temperature of 40°C, then slowly add 0.8g of cinnamon oil and stir for 1.5h, then add 20g lavender essential oil, 10g of tea tree oil and 3g of cedarwood oil were stirred for 1.5h, and finally 1g of mugwort leaf oil and 0.8g of star anise oil were slowly added successively, and the stirring was continued until it became clear and transparent, and the finished product was obtained.

Example 3

Dissolve 20g of menthol and 60g of liquid paraffin in a water bath at 40°C, place it on a magnetic stirrer with a rotation speed of 30r/min and a temperature of 50°C, then slowly add 1g of cinnamon oil and stir for 1 hour, then add 10g of lavender Essential oil, 5g of tea tree oil and 2g of cedarwood oil were stirred for 1 hour, and finally 0.8g of mugwort leaf oil and 0.5g of star anise oil were slowly added in sequence, and the stirring was continued until it was clear and transparent, and the finished product was obtained.

Example 4

Dissolve 35g of menthol and 90g of liquid paraffin in a 40°C water bath, place it on a magnetic stirrer with a rotation speed of 30r/min and a temperature of 50°C, then slowly add 1.5g of cinnamon oil and stir for 3 hours, then add 28g of Lavender essential oil, 12g of tea tree oil and 4g of cedarwood oil were stirred for 3 hours, and finally 1.8g of mugwort oil and 1.2g of star anise oil were slowly added in turn, and the stirring was continued until it was clear and transparent, and the finished product was obtained.

Example 5

Dissolve 18g of menthol and 75g of liquid paraffin in a 40°C water bath, place it on a magnetic stirrer with a rotation speed of 30r/min and a temperature of 50°C, then slowly add 0.65g of cinnamon oil and stir for 1h, then add 15g of Lavender essential oil, 15g of tea tree oil and 2.5g of cedarwood oil were stirred for 1 hour, and finally 1.5g of mugwort oil and 0.65g of star anise oil were slowly added successively, and the stirring was continued until it was clear and transparent, and the finished product was obtained.

The clinical efficacy observation results are as follows :

The data were collected from 100 acne patients who visited the Second Hospital of Jilin University from 2013 to 2014, including 45 males and 55 females. The oldest age was 42 years old, the youngest age was 16 years old, and the average age was 29 years old. Degree of illness: 23 cases were mild, 42 cases were moderate, and 35 cases were severe. They were healthy in previous physical examinations. The diagnostic criteria refer to "Dermatology Diagnosis, Treatment and Rehabilitation".

Efficacy Evaluation Criteria

Healed: all skin lesions healed and returned to normal; Markedly effective: 85% of skin lesions healed; Effective: 50% of skin lesions healed; Ineffective: The primary skin lesions did not improve.

Disease severity assessment

Mild acne: skin lesions mainly comedones; moderate acne: skin lesions mainly comedones and pustules; severe acne: nodular acne, cystic acne, acne conglomerates, etc.

Efficacy statistics

[Treatment method] Dip the compound liniment of plant extracts of Examples 1-5 prepared above with a cotton swab, and apply it evenly on the affected area, the area is slightly larger than the skin lesion, once in the morning, noon and night, and the course of treatment is one month. Control group 1 (a mixture that can remove acne and acne marks, publication number: CN102335287A), control group 2 (a compound essential oil for acne pigmentation, publication number: CN103655382A) externally applied 3 times a day for 4 weeks For 1 course of treatment. The 7 groups of patients all had one course of treatment for 4 weeks, and the results were judged after one course of treatment. The results are shown in Tables 1 and 2.

Table 1 Comparison of clinical efficacy of patients

group get well markedly effective efficient invalid Healing rate Control group 1 35 29 20 6 64% Control group 2 32 38 twenty two 8 70% Example 1 45 53 2 0 98% Example 2 42 52 4 2 94% Example 3 38 50 8 4 88% Example 4 42 45 10 3 87% Example 5 40 49 9 2 89%

Table 2 Comparison of curative effects in patients with different disease degrees

group degree get well markedly effective efficient invalid Healing rate Control group 1 Mild (23) 12 8 2 1 87% moderate(42) 10 10 20 2 47.6% Severe (35) 0 8 20 5 22.9% Control group 2 Mild (23) 13 6 3 1 82.6% moderate(42) 10 10 20 2 47.6% Severe (35) 0 8 20 5 22.9% Example 1 Mild (23) 20 3 0 0 100% moderate(42) 30 9 2 1 92.9% Severe (35) 15 14 5 1 82.9% Example 2 Mild (23) 18 5 0 0 100% moderate(42) 25 10 5 2 83.3% Severe (35) 12 13 5 5 71.4% Example 3 Mild (23) twenty one 2 0 0 100% moderate(42) twenty three 9 6 4 76.2% Severe (35) 10 14 5 6 68.6% Example 4 Mild (23) 17 6 0 0 100% moderate(42) 20 12 7 5 76.2% Severe (35) 13 13 5 4 74.3% Example 5 Mild (23) 19 4 0 0 100% moderate(42) 25 10 5 2 83.3% Severe (35) 13 15 3 4 80%

The above description is not a limitation of the present invention, and the present invention is not limited to the above examples. Any changes, changes, additions or substitutions made by those of ordinary skill in the art within the scope of the present invention shall all belong to the scope of the present invention. protected range.

Claims (4)

1. a plant extract compound liniment for the treatment of acne and acne, characterized in that it is made of the following medicines in parts by weight: Lavender essential oil 10-30, tea tree oil 5-25, cedar oil 2-5, mugwort oil 0.8-2, star anise oil 0.5-1.2, cinnamon oil 0.5-2, liquid paraffin 60-100, menthol 18-40. 2. a kind of plant extract compound liniment for treating acne and acne as claimed in claim 1, its preferred weight portion proportioning is: Lavender essential oil 25, tea tree oil 20, cedar oil 5, mugwort oil 2, star anise essential oil 1, cinnamon oil 0.5, liquid paraffin 100, menthol 40. 3. the preparation method of a kind of plant extract compound liniment for treating acne and acne described in claim 1/2, comprising the following steps: Dissolve menthol and liquid paraffin in a water bath, then add cinnamon oil and stir on a magnetic stirrer, then add lavender essential oil, tea tree oil, cedar oil, mugwort oil, and star anise oil in proportion to continue stirring, and the stirring temperature is 20-40°C, the stirring speed is 30-60 rpm, and the stirring time is 1-4 hours, until it is clear and transparent. 4. A kind of plant extract compound liniment for treating acne and acne according to claim 1/2, characterized in that, the composition can be made into gel, ointment by adding auxiliary materials such as other solubilizers or non-aqueous solvents , Sprays, lotions, suppositories and other disinfectants for skin and mucous membranes, disinfectant wipes, disinfectant gauze, band-aids and other disinfection products.