CN101361938A - Kibe paste containing natural zingiber oil - Google Patents
Kibe paste containing natural zingiber oil Download PDFInfo
- Publication number
- CN101361938A CN101361938A CNA2008100703694A CN200810070369A CN101361938A CN 101361938 A CN101361938 A CN 101361938A CN A2008100703694 A CNA2008100703694 A CN A2008100703694A CN 200810070369 A CN200810070369 A CN 200810070369A CN 101361938 A CN101361938 A CN 101361938A
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- CN
- China
- Prior art keywords
- oil
- portions
- vaseline
- chilblain
- pinene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000234314 Zingiber Species 0.000 title claims description 7
- 229940099259 vaseline Drugs 0.000 claims abstract description 20
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 19
- 239000010642 eucalyptus oil Substances 0.000 claims abstract description 19
- 229940044949 eucalyptus oil Drugs 0.000 claims abstract description 19
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 18
- 239000003921 oil Substances 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 229940025250 camphora Drugs 0.000 claims description 18
- 239000010238 camphora Substances 0.000 claims description 18
- 239000002674 ointment Substances 0.000 claims description 15
- -1 pinene Substances 0.000 claims description 8
- 239000012467 final product Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 2
- 208000010445 Chilblains Diseases 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 13
- 230000035876 healing Effects 0.000 abstract description 10
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 2
- 230000007803 itching Effects 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract 3
- 239000004615 ingredient Substances 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 241000146412 Zingiber corallinum Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 10
- 208000025865 Ulcer Diseases 0.000 description 8
- 231100000397 ulcer Toxicity 0.000 description 8
- 238000002156 mixing Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000036592 analgesia Effects 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 230000001148 spastic effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides a chilblain cream with reliable antibiosis effect, short time of therapy, low cost and simple preparation method. The product consists of the ingredients with the following weight portions: 1-6 portions of Zingiber corallinum Oil, 2-6 portions of eucalyptus oil, 5-10 portions of pinene, 20-30 portions of camphor, 0.1-0.4 portion of borneol, and 50-70 portions of Vaseline; all ingredients are added into a heating vessel, well stirred and heated to 80 to 85 DEG C, homogenized for 5-10 minutes, and finally cooled, thus the chilblain cream is prepared. The chilblain cream has the advantages of significant sterilization effect, detumescence, analgesis, itching relieving functions, promoting blood circulation, accelerating the healing of chilblain, rapid onset time, short therapy time and high cure rate.
Description
Technical field
The present invention relates to a kind of external chilblain unguentum for the treatment of chilblain, particularly a kind of is the chilblain unguentum of main curative effect composition with natural zingiber oil.
Background technology
Chilblain is a kind of disease that easily suffer from positions such as human body face, hands, foot under the cold climate, is owing to the impaired irregular erythema of aubergine that causes local telangiectasis, permeability increase, tissue edema to form of the cold moist spastic contraction of small subcutaneous arteries, the histanoxia that causes; Have scorching hot and the sufferings sense, if untimely treatment, serious occurred blister, ulcer.Chilblain is brought many miseries and worry to people, influences people's work, study and life.The medicament categories of existing treatment chilblain is various, and applicable object, the curative effect of these medicaments all have nothing in common with each other.The antibacterial effect that has is poor, and treatment time is long, and cure rate is not high, and the medication composition that has is a lot, and the cost height is made comparatively trouble.The chilblain to broken skin that has can not be used, and significant limitation is arranged.
Summary of the invention
The purpose of this invention is to provide that a kind of antibacterial effect is reliable, treatment time is short, lower, the simple kibe ointment of preparation method of cost.
The technical scheme that adopts is as follows: take by weighing various raw materials by following parts by weight earlier: Oleum Zingiberis corallini 1～6, eucalyptus oil 2～6, pinene 5～10, Camphora 20～30, Borneolum Syntheticum 0.1～0.4, vaseline 50～70; Oleum Zingiberis corallini, eucalyptus oil, pinene, Camphora, Borneolum Syntheticum, vaseline are added in the heating container, stir and be heated to 80～85 ℃, homogenizing 5～10 minutes, to be cooled getting final product.
In order to improve the abnormal smells from the patient of kibe ointment, to be cooledly add essence during to 35～45 ℃, its parts by weight are 0.1～2.0.
Various raw materials in part by weight scope preferably are: Oleum Zingiberis corallini 3～5, eucalyptus oil 3～5, pinene 7～9, Camphora 23～28, Borneolum Syntheticum 0.2～0.3, vaseline 55～65, essence 0.5～1.5.
It is to be main curative effect composition with natural zingiber oil, eucalyptus oil, pinene, Camphora, vaseline that the present invention is different from prior art, and makes by described method, and various raw materials all can be bought from market.
Oleum Zingiberis corallini is a kind of good efficiency natural antibacterial, and it has broad-spectrum antibacterial action as antibacterial.Through Rhizoma Zingiberis corallini quintessence oil to the antibacterial activity analysis of the penicillin-fast golden Portugal of the 30 strains bacterium of clinical AD skin lesion surface isolation, in the penicillin-fast golden Portugal of the 30 strains bacterium 28 strains to the Rhizoma Zingiberis corallini quintessence oil sensitivity, responsive rate 93.3%.Rhizoma Zingiberis corallini quintessence oil contains terpinene-4-alcohol, also has effects such as heat-clearing and toxic substances removing, anti-inflammatory analgetic, detumescence, can prevent that treating chilblain festers, and quickens ulcer healing.
Eucalyptus oil mainly contains the 1.8-cineole, have sterilization, antipruritic, ease pain, improve effects such as skin inflammatory status.Clinical proof all has stronger sterilization and bacteriostasis to gram positive bacteria and negative bacterium.Be added in and play bactericidal antiphlogistic, the effect of analgesia itching relieving in the kibe ointment of the present invention.
Pinene has terebinthine abnormal smells from the patient, the oidiomycetic biosynthesis of white there is significant inhibitory effect, its antibacterial mechanisms is to reach the synthetic of inhibition nucleic acid DNA, RNA by the synthetic of chitin, polysaccharide in ergosterol, the cell wall in the inhibition albicans cell film, thereby plays bactericidal action.Being used for kibe ointment can sterilization, blood circulation promoting, promotion skin healing, has the effect of the infiltration of helping simultaneously.
Camphora has invigorating blood circulation, eases pain and promotes the effect of wound healing, and energy conjunctive tissue cell quickens to generate the material of replacing damaged tissue; Blood capillary is increased to wound blood supply or the like, and accelerating wound healing is being controlled wound healing and repair process, in the treatment chilblain, can improve skin histology blood circulation, analgesia. repellent antipruritic, promote the effect of ulcer healing.
Vaseline is a kind of mineral wax, can form protecting film one in skin surface, is a kind of good skin moistening skin protectant.Because chemical inertness, the skin of any kind all there is not stimulation.The protecting film that vaseline forms can prevent that ulcer from contacting with air, is beneficial to ulcer healing.In this kibe ointment, can prevent that chilblain skin from being infected, accelerate the chilblain ulcer healing, bring into play the effect of skin-moisturizing, skin simultaneously.
Borneolum Syntheticum is cold and cool partially, and the merit of clearing away heat to alleviate pain, detumescence is arranged, and is used for skin infection more and swells and ache, and does not hold back after bursting.Energy clearing heat for detumescence, erosion prevention and muscle growing, promotion ulcer healing in this agent.
Kibe ointment usage of the present invention: directly smear the affected part, smear every day 2～3 times, smear continuously after 3～5 days and both can fully recover, cure rate reaches 100%, does not recur after healing.Smear continuously and can revert to normal skin at chilblain cicatrix place.In addition, but be applied in the easy kibed position of human body anti-frostbite with kibe ointment of the present invention and take place.
Kibe ointment of the present invention has carried out clinical practice to 100 routine patients, and is evident in efficacy, has cure rate to reach 100%, do not see incompatibility or irritation person.
The beneficial effect of kibe ointment of the present invention is: bactericidal effect is remarkable, and energy detumescence, analgesia, antipruritic, blood circulation promoting quicken the chilblain ulcer healing, instant effect, and treatment time is short, the cure rate height, the back preventing from scar of healing, cost is low, and preparation method is simple.
Specific embodiment (totally 5 examples)
The unit of weight of various raw materials is kilogram among all embodiment.
Embodiment 1
Get Oleum Zingiberis corallini 6, eucalyptus oil 5, pinene 8, Camphora 25, Borneolum Syntheticum 0.4, vaseline 60, Oleum Zingiberis corallini, eucalyptus oil, vaseline, Camphora, pinene, Borneolum Syntheticum are added in the heating container, be heated with stirring to 82 ℃, homogenizing 10 minutes, cooling gets final product.
Embodiment 2
Get Oleum Zingiberis corallini 1, eucalyptus oil 2, pinene 10, Camphora 30, Borneolum Syntheticum 0.2, vaseline 50, essence 0.1, Oleum Zingiberis corallini, eucalyptus oil, vaseline, Camphora, pinene, Borneolum Syntheticum are added in the heating container, be heated with stirring to 85 ℃, homogenizing 5 minutes, be cooled to 35 ℃, add essence, mixing gets final product.
Embodiment 3
Get Oleum Zingiberis corallini 4, eucalyptus oil 6, pinene 5, Camphora 20, Borneolum Syntheticum 0.1, vaseline 70, essence 2, Oleum Zingiberis corallini, eucalyptus oil, vaseline, Camphora, pinene, Borneolum Syntheticum are added in the heating container, be heated with stirring to 80 ℃, homogenizing 8 minutes, be cooled to 45 ℃, add essence, mixing gets final product.
Embodiment 4
Get Oleum Zingiberis corallini 3, eucalyptus oil 3, pinene 7, Camphora 23, Borneolum Syntheticum 0.2, vaseline 55, essence 1 adds Oleum Zingiberis corallini, eucalyptus oil, vaseline, Camphora, pinene, Borneolum Syntheticum in the heating container, be heated with stirring to 80 ℃, homogenizing 8 minutes is cooled to 45 ℃, add essence, mixing gets final product.
Embodiment 5
Get Oleum Zingiberis corallini 5, eucalyptus oil 5, pinene 9, Camphora 28, Borneolum Syntheticum 0.3, vaseline 65, essence 1.5 adds Oleum Zingiberis corallini, eucalyptus oil, vaseline, Camphora, pinene, Borneolum Syntheticum in the heating container, be heated with stirring to 80 ℃, homogenizing 8 minutes is cooled to 45 ℃, add essence, mixing gets final product.
Claims (3)
1, a kind of kibe ointment that contains natural zingiber oil is characterized in that preparing as follows:
(1), takes by weighing various raw materials by following parts by weight: Oleum Zingiberis corallini 1～6, eucalyptus oil 2～6, pinene 5～10, Camphora 20～30, Borneolum Syntheticum 0.1～0.4, vaseline 50～70;
(2), Oleum Zingiberis corallini, eucalyptus oil, pinene, Camphora, Borneolum Syntheticum, vaseline are added in the heating container, stir and be heated to 80～85 ℃, homogenizing 5～10 minutes, to be cooled getting final product.
2, the kibe ointment that contains natural zingiber oil as claimed in claim 1 is characterized in that step (2) essence that adds parts by weight 0.1～2.0 during to 35～45 ℃ to be cooled.
3, the kibe ointment that contains natural zingiber oil as claimed in claim 2 is characterized in that various raw materials in part by weight are in the step (1): Oleum Zingiberis corallini 3～5, eucalyptus oil 3～5, pinene 7～9, Camphora 23～28, Borneolum Syntheticum 0.2～0.3, vaseline 55～65.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100703694A CN101361938A (en) | 2008-09-24 | 2008-09-24 | Kibe paste containing natural zingiber oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100703694A CN101361938A (en) | 2008-09-24 | 2008-09-24 | Kibe paste containing natural zingiber oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101361938A true CN101361938A (en) | 2009-02-11 |
Family
ID=40388666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100703694A Pending CN101361938A (en) | 2008-09-24 | 2008-09-24 | Kibe paste containing natural zingiber oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101361938A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000004A (en) * | 2010-01-29 | 2011-04-06 | 重庆灵方生物技术有限公司 | Inflammation diminishing and pain relieving lipstick containing zingiber corallinum hance essential oil |
| CN101708316B (en) * | 2009-12-09 | 2011-05-11 | 赵守朋 | Ointment for treating chilblain |
| CN102755459A (en) * | 2012-06-28 | 2012-10-31 | 固镇县中医院 | External ointment for treating chilblain and preparation method of external ointment |
-
2008
- 2008-09-24 CN CNA2008100703694A patent/CN101361938A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708316B (en) * | 2009-12-09 | 2011-05-11 | 赵守朋 | Ointment for treating chilblain |
| CN102000004A (en) * | 2010-01-29 | 2011-04-06 | 重庆灵方生物技术有限公司 | Inflammation diminishing and pain relieving lipstick containing zingiber corallinum hance essential oil |
| CN102000004B (en) * | 2010-01-29 | 2011-12-07 | 重庆灵方生物技术有限公司 | Inflammation diminishing and pain relieving lipstick containing zingiber corallinum hance essential oil |
| CN102755459A (en) * | 2012-06-28 | 2012-10-31 | 固镇县中医院 | External ointment for treating chilblain and preparation method of external ointment |
| CN102755459B (en) * | 2012-06-28 | 2014-07-30 | 固镇县中医院 | External ointment for treating chilblain and preparation method of external ointment |
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Open date: 20090211 |