CN1051506A - Preparation method of novel sanguisorba officinalis preparation - Google Patents
Preparation method of novel sanguisorba officinalis preparation Download PDFInfo
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- CN1051506A CN1051506A CN 90108019 CN90108019A CN1051506A CN 1051506 A CN1051506 A CN 1051506A CN 90108019 CN90108019 CN 90108019 CN 90108019 A CN90108019 A CN 90108019A CN 1051506 A CN1051506 A CN 1051506A
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Abstract
The invention takes garden burnet as raw material, and after the processes of crushing, decocting in water, concentrating and the like, the garden burnet is prepared into tablets, powder, capsules and other dosage forms respectively containing 5mg, 10mg, 100mg and 500mg of crude drugs, and the garden burnet can be used for treating acne, rosacea, thrombophlebitis, intestinal adhesion, chronic nonspecific ulcerative colitis, leukopenia and immunodeficiency and has antibacterial and synergistic effects.
Description
The invention belongs to a kind of production method of Chinese medicine, relate in particular to the preparation process of this medicine.It is to be raw material with the Chinese medicine Radix Sanguisorbae, after process preparation technology of the present invention makes medicine, treatment acne, rosacea, thrombophlebitis, intestinal adhesion, chronic non-specific ulcerative colitis, leukopenia, immunodeficiency disease and antibiotic synergic effect have been produced.
In the prior art, for acne, thrombophlebitis, leukopenia, various Therapeutic Method is arranged.In No. 881067463 applications, make medicinal liquid with natural pearls, Fructus Xanthii, Radix Sophorae Tonkinensis, Herba Spirodelae, can be used for treating acne, acne.Human danggui sini decoction treatment thromboangiitis [journal of shanghai Chinese medicine (8): 18,1965] is arranged.Somebody's report is treated leukopenia with the GUIPI TANG plus-minus, and has obtained certain effect [Shaanxi new medicine, (9): 26,1979].Up to now, find no human Rhizoma sanguisorbae preparation treatment acne, rosacea, thrombophlebitis, intestinal adhesion, chronic non-specific ulcerative colitis, leukopenia, immunodeficiency disease.Radix Sanguisorbae is promptly on the books in Shennong's Herbal: " housewife's human milk convulsion pain, seven kinds of impairments, leukorrheal diseases, pain relieving, remove and dislike meat, hidroschesis, treatment incised wound ".The record Radix Sanguisorbae has cooling blood for hemostasis in " Chinese medicine voluminous dictionary ", the effect of heat-clearing and toxic substances removing, diseases such as treatment haematemesis, epistaxis, dysentery, metrorrhagia, burn.Many at present utilization Radix Sanguisorbae treatment burns, bacillary dysentery etc.Report with Chinese medicine Radix Sanguisorbae mixture treatment acute bacillary dysentery to have certain effect (Xuzhou Medical College's journal second phase in 1981) if any the people.Record adds in the Oleum Sesami or vegetable oil that boils with Radix Sangusorbae powder I, II degree burn in " Chinese medicine voluminous dictionary ", stirs into pasty state, puts coldly, is coated with and hinders face, effect such as control infection, pain relieving are arranged, the promotion wound face heals rapidly and protect from infection.At present adopt compound preparation (as the medical officer people, the fifth phase in 1981) or decoct mixture (Xuzhou Medical College's journal, the second phase in 1981) for the use of Radix Sanguisorbae more.The possessor attempts to make the tablet of single Radix Sanguisorbae medicine to the greatest extent, because the restriction of preparation process, this medicine can only be used for hemostasis, convergence and treatment bacillary dysentery, and do not see operation for a long time because of curative effect is unreliable always.
In the prior art, usually can be and patient is developed immunity to drugs to antibiotics because of the improper use of antibiotics or unknown cause, even some infectious disease is insensitive to antibiotics, has brought many inconvenience to anti-infective therapy.Thereby seek a kind of Trimethoprim and for anti-infective therapy, have crucial meaning.
Purpose of the present invention is exactly in order to overcome above-mentioned defective of the prior art, by particular formulations technology of the present invention, prepare and a kind ofly can treat acne, rosacea, thrombophlebitis, intestinal adhesion, chronic non-specific ulcerative colitis, leukopenia, immunodeficiency disease effectively, and have the new type sanguisorba pharmaceutical of antibiotic potentiation.
In order to reach the purpose of treatment acne, rosacea, thrombophlebitis, intestinal adhesion, chronic non-specific ulcerative colitis, leukopenia, immunodeficiency disease and antibiotic potentiation, must adopt particular formulations technology of the present invention.The inventor is through a large amount of scientific experimentation and clinical observation, by the screening system medicine with carry out preparation process research, seek out with Radix Sanguisorbae as material medicine, and prepare patent medicine, just brought various medical function by special process described below.
The present invention realizes like this.
1, sterilization is pulverized, is sieved.
Radix Sangusorbae is chosen decontamination, wash, thinly slice, dry, as raw medicinal material.Get the medical material of crude drug full dose 1/3rd, in the steriliser of packing into, carried out moist heat sterilization 30 minutes at 110 ℃, drying is ground into fine powder, and it is standby to cross 100 mesh sieves.
2, decocting and concentrating:
The medical material of crude drug residue 2/3rds amounts is decocted with water three times, respectively boiled 1.5 hours with the second time for the first time, amount of water is 6.5 times of medical material amount, boils for the third time 1 hour, and amount of water is 4 times of medical material amount.With medical filtration, merging filtrate is concentrated into the thick paste of relative density (60 ℃) more than 1.15, and receiving the cream amount is 1/2nd of decoction amount.
Decocting number of times, time and water consumption are very important and are necessary that process is groped for the present invention, and the medicinal liquid medical function for medicine in preparation process that decocts three gained by above-mentioned condition has crucial meaning.
3, granulate:
Pelletization also is the link of a ten minutes of the present invention importance, it directly has influence on the clinical effect and the curative effect of this medicine, with crude drug powder 5000 grams, thick paste 5000 grams, Icing Sugar 1070 grams, starch 1430 grams are mixed and made into soft material, dry, break into fine powder, an amount of with 50% ethanol, 16# granulates, dried granule 9000 grams+5% of dry receipts, add 1% magnesium stearate or 3% Pulvis Talci mixing behind the dried granule granulate, calculate slice and heavily be respectively 0.3 gram and two kinds of specifications of 0.06 gram, make it to be equivalent to contain crude drug 500mg and 100mg.Can also be with crude drug powder 50 grams (or 100 grams), Icing Sugar 400 grams, starch 450 grams (or 400 grams) add magnesium stearate 10 grams or Pulvis Talci 25 grams, add 10% starch slurry 180ml again and mix, make granule, drying, granulate, calculating sheet heavily is 0.09 gram, makes it to be equivalent to contain crude drug 5mg(or 10mg).
4, tabletting, coating.
Heavy by the sheet that calculates, punching press is in blocks, and coupon is heavy at any time, carries out coating then.
5, quality inspection.
Tablet regulation by 1985 editions one one of Chinese Pharmacopoeia is carried out quality examination.
6, packing.
100 every bottle, to seal tightly, packing is neat.
The method according to this invention can also be mixed and made into crude drug powder and/or decocting medicinal liquid condensed cream specification and be respectively and be equivalent to contain crude drug 5mg, 10mg, 100mg, the powder of 500mg and capsule.
According to the inventive method, Radix Sanguisorbae decocting liquid can also be prepared into and be equivalent to contain crude drug and be respectively 5mg, 10mg, 100mg, Radix Sanguisorbae oral liquid or the injection of 500mg.
The prepared product of the inventive method has good medical effect aspect treatment acne, rosacea, thrombophlebitis, intestinal adhesion, chronic non-specific ulcerative colitis, leukopenia, immunodeficiency disease and the antibiotic potentiation.These medical functions are that the institute of Rhizoma sanguisorbae preparation described in the prior art is inaccessiable.As seen the inventive method has bigger superiority than prior art aspect preparation process, for the treatment of acne, rosacea, thrombophlebitis, intestinal adhesion, chronic non-specific ulcerative colitis, immunodeficiency disease provides a kind of effective pharmaceutical preparation.And for anti-infective therapy provides a kind of curative effect sure Trimethoprim.
Through the prepared product of the present invention of the inventive method different medical functions is arranged.The disease that the Drug therapy of various dose specification is different is an important content of the present invention.To be the inventor observe through a large amount of clinical practices for this, the medical effect that preparation process of the present invention brought that designs according to different clinical needs.
Using the prepared specification of the inventive method is every tablet of medicine that is equivalent to contain crude drug 100mg, can be used for the treatment of acne, rosacea, thrombophlebitis and intestinal adhesion, and can be used as Trimethoprim and treatment pyogenic infection.The application of the invention product treatment ordinary base sore 101 routine clinical observations, and treat 62 examples with zinc glycyrrhizate and compare group found that its curative effect and no less than zinc glycyrrhizate, and take safety, do not find any pair of effect.Use product of the present invention to be used for the treatment of thrombophlebitis, curing the back blood vessel can lead to again, uses some other antibiotics poor effect, and uses product of the present invention can reach 100% effective percentage.Use product treatment rosacea of the present invention and intestinal adhesion also to obtain certain curative effect.Use product treatment pyogenic infection of the present invention also to obtain good curative effect.
Carry out antibiotic synergism test with the MH culture medium that WHO recommends, found that the present invention produces penicillin, streptomycin, tetracycline, gentamycin, kanamycin, erythromycin, chloromycetin, AEROSPORIN and sulfanilamide SMZ are had potentiation, its potentiation multiple can reach several times to tens times.
Before this, the someone did not use Radix Sanguisorbae sheet treatment leukopenia and immunodeficiency disease, the inventor is by a large amount of clinical observations, and to the selection of technology, every for preparing contains the Radix Sanguisorbae tablet that is equivalent to crude drug 5mg, have the medical function of treatment leukopenia and immunodeficiency disease, and obtained excellent curative, for leukopenia and immunodeficiency disease patient provide a kind of curative effect reliable medicine.The treatment leukopenia can be with containing the product of the present invention that crude drug is equivalent to 5mg or 10mg.This medicine not only has therapeutical effect to the primary leukopenia of unknown cause, and for tumor radiotherapy, leukopenia caused by cancer chemotherapy disease, and the leukopenia that other medicines cause all has therapeutical effect, by the clinical treatment observation to 110 routine patients, total effective rate reaches 96.36%.
In addition, the product that uses every of the present invention to be equivalent to contain crude drug 500mg is used for acute bacillary dysentery, can reach 100% effect, and use the effect 97.12% of FUFANG DIYU PIAN treatment bacillary dysentery in the prior art, be lower than product curative effect of the present invention (the medical officer people, 1981 the 5th phase the 33rd page).The preparation process of the inventive method and FUFANG DIYU PIAN is completely different, and what FUFANG DIYU PIAN adopted is that Radix Sanguisorbae is fried to outer telogenesis charcoal, and what use in the inventive method is Radix Sangusorbae.Process the inventive method has been brought good medical effect like this after making and containing the tablet that is equivalent to the 500mg crude drug, and the different and advantage of the present invention with prior art also has been described from another point of view.
Use every of the present invention to be equivalent to contain the product of crude drug 500mg, be used for the treatment of acute bacterial (stomach) enteritis 126 examples, can reach 100% effect; Be used for the treatment of chronic non-specific ulcerative colitis 21 examples, can reach 85.7% effect, the superiority of the inventive method also is described.
The inventive method can be further described by the following example, but the present invention is not played any restriction.
Embodiment 1
Get 15000 gram Radix Sangusorbaes, in 110 ℃ of following moist heat sterilizations 30 minutes, drying was ground into fine powder in steriliser, and it is standby to cross 100 mesh sieves.Get 30000 gram Radix Sangusorbaes again, respectively add 195 kilograms in water, respectively boiled 1.5 hours for the 1.2nd time, add 120 kilograms in water the 3rd time, boiled 1 hour, three medical filtrations, merging filtrate is concentrated into the thick paste of relative density (60 ℃) more than 1.15, and receiving the cream amount is 1/2 of decoction amount.With the above-mentioned Radix Rehmanniae elm powder of 15000 grams, 30000 gram Radix Sanguisorbae decocting liquid concentrate thick paste 15000 grams of back gained, mix with Icing Sugar 3210 grams and starch 4290 grams together, mix thoroughly, make soft material, drying, break into fine powder, an amount of with 50% ethanol, 16# granulates, drying, granulate, by sheet heavily be respectively 0.06 gram and 0.3 gram compacting in blocks, coating makes every to be equivalent to contain the crude drug amount and to be respectively 100mg and 500mg.
Embodiment 2,
Get Radix Sangusorbae medical material 100 grams, in the steriliser of packing into, carried out moist heat sterilization 30 minutes at 110 ℃, drying is ground into fine powder, crosses 100 mesh sieves, mix with Icing Sugar 800 gram, starch 900 grams, magnesium stearate 20 grams, stir after adding 10% starch slurry 360ml, make granule, dry, granulate, compacting is in blocks, and sheet heavily is 0.09 gram, coating, pack, every is equivalent to contain crude drug 5mg.
Claims (6)
1, a kind of preparation method of new type sanguisorba pharmaceutical, it is characterized in that selecting for use Radix Sanguisorbae is raw material, with the Radix Sanguisorbae of crude drug full dose 1/3 at 110 ℃ of following moist heat sterilizations after 30 minutes, be dried and crushed into fine powder, to remain the Radix Sanguisorbae decocting in water 3 times of 2/3 amount again, and respectively boil 1.5 hours for preceding twice, amount of water is 6.5 times of medical material amount, boiled 1 hour for the 3rd time, amount of water is 4 times of medical materials, merges medical filtration, is condensed into thick paste, after crude drug powder and/or thick paste mixing adding sugar and starch, a system compacting in flakes.
2, a kind of preparation method as claimed in claim 1, it is characterized in that with Radix Rehmanniae elm powder 50 grams, Icing Sugar 400 grams, starch 450 grams, magnesium stearate 10 grams (or Pulvis Talci 25 grams), after adding 10% starch slurry 180ml mixing, make the tablet that is equivalent to contain crude drug 5mg.
3, a kind of preparation method as claimed in claim 1, it is characterized in that with Radix Rehmanniae elm powder 100 grams, Icing Sugar 400 grams, starch 400 grams, magnesium stearate 10 gram (or Pulvis Talci 25 grams) after adding 10% starch slurry 180ml and mixing, is made the tablet that is equivalent to contain crude drug 10mg.
4, a kind of preparation method as claimed in claim 1 is characterized in that, can also be condensed into thick paste with Radix Rehmanniae elm powder and/or Radix Sanguisorbae decocting liquid, makes to be equivalent to contain electuary or the capsule that crude drug is respectively 5mg, 10mg, 100mg and 500mg.
5, a kind of preparation method as claimed in claim 1 is characterized in that being prepared into Radix Sanguisorbae decocting liquid and is equivalent to contain the oral liquid that crude drug is respectively 5mg, 10mg, 100mg and 500mg.
6, a kind of preparation method as claimed in claim 1 is characterized in that making with Radix Sanguisorbae decocting liquid and is equivalent to contain the injection that crude drug is respectively 5mg, 10mg, 100mg and 500mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90108019 CN1016141B (en) | 1990-10-08 | 1990-10-08 | Preparation method of novel sanguisorba officinalis preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90108019 CN1016141B (en) | 1990-10-08 | 1990-10-08 | Preparation method of novel sanguisorba officinalis preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1051506A true CN1051506A (en) | 1991-05-22 |
| CN1016141B CN1016141B (en) | 1992-04-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90108019 Expired CN1016141B (en) | 1990-10-08 | 1990-10-08 | Preparation method of novel sanguisorba officinalis preparation |
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| CN (1) | CN1016141B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052156C (en) * | 1993-04-14 | 2000-05-10 | 刘墨森 | Medicine for curing acne-"Fenciling" |
| CN1935147B (en) * | 2002-12-02 | 2010-05-19 | 成都地奥制药集团有限公司 | New use of radix sanguisorbae total saponin extract |
| CN101810706A (en) * | 2009-05-26 | 2010-08-25 | 成都地奥集团天府药业股份有限公司 | Preparation method of garden burnet solid preparation with low dose |
| CN101204473B (en) * | 2007-12-12 | 2010-12-15 | 叶志军 | Chinese traditional medicine preparation for abcchia rosacea |
| CN102961649A (en) * | 2012-11-14 | 2013-03-13 | 朱新华 | Traditional Chinese medicine abrasive cleaner for effectively treating rosacea |
| CN103372076A (en) * | 2012-04-20 | 2013-10-30 | 北京北大维信生物科技有限公司 | Medicine for treating diseases caused by propionibacterium acnes and application of sanguisorba officinalis and/or sanguisorba officinalis extract |
| CN103432561A (en) * | 2013-09-11 | 2013-12-11 | 刘春红 | Traditional Chinese medicament for treating phlebitis |
| CN104857116A (en) * | 2014-02-21 | 2015-08-26 | 中国人民解放军第二军医大学 | Applications of traditional Chinese medicine sanguisorba officinalis in preparing antifungal drug synergist |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100366258C (en) * | 2003-09-08 | 2008-02-06 | 成都地奥制药集团有限公司 | Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine |
-
1990
- 1990-10-08 CN CN 90108019 patent/CN1016141B/en not_active Expired
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052156C (en) * | 1993-04-14 | 2000-05-10 | 刘墨森 | Medicine for curing acne-"Fenciling" |
| CN1935147B (en) * | 2002-12-02 | 2010-05-19 | 成都地奥制药集团有限公司 | New use of radix sanguisorbae total saponin extract |
| CN101204473B (en) * | 2007-12-12 | 2010-12-15 | 叶志军 | Chinese traditional medicine preparation for abcchia rosacea |
| CN101810706A (en) * | 2009-05-26 | 2010-08-25 | 成都地奥集团天府药业股份有限公司 | Preparation method of garden burnet solid preparation with low dose |
| CN101810706B (en) * | 2009-05-26 | 2011-03-16 | 成都地奥制药集团有限公司 | Preparation method of garden burnet solid preparation with low dose |
| CN103372076A (en) * | 2012-04-20 | 2013-10-30 | 北京北大维信生物科技有限公司 | Medicine for treating diseases caused by propionibacterium acnes and application of sanguisorba officinalis and/or sanguisorba officinalis extract |
| CN103372076B (en) * | 2012-04-20 | 2015-10-14 | 北京北大维信生物科技有限公司 | Treat the medicine of disease and the application of Radix Sanguisorbae and/or Radix Sangusorbae extract that are caused by propionibacterium acnes |
| CN102961649A (en) * | 2012-11-14 | 2013-03-13 | 朱新华 | Traditional Chinese medicine abrasive cleaner for effectively treating rosacea |
| CN102961649B (en) * | 2012-11-14 | 2014-08-20 | 谭洪武 | Traditional Chinese medicine abrasive cleaner for effectively treating rosacea |
| CN103432561A (en) * | 2013-09-11 | 2013-12-11 | 刘春红 | Traditional Chinese medicament for treating phlebitis |
| CN103432561B (en) * | 2013-09-11 | 2015-06-24 | 刘春红 | Traditional Chinese medicament for treating phlebitis |
| CN104857116A (en) * | 2014-02-21 | 2015-08-26 | 中国人民解放军第二军医大学 | Applications of traditional Chinese medicine sanguisorba officinalis in preparing antifungal drug synergist |
| CN104857116B (en) * | 2014-02-21 | 2018-11-02 | 中国人民解放军第二军医大学 | Application of the Chinese medicine garden burnet in preparing antifungal medicine synergist |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1016141B (en) | 1992-04-08 |
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| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
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Owner name: CHENGDU TIANFU DIAO PHARMACEUTICAL GROUP CO. Free format text: FORMER OWNER: LIU MOSEN Effective date: 20070413 |
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Effective date of registration: 20070413 Address after: 635000 Dazhou City, Sichuan Province Jian min Lu, Tongchuan District No. 96 Patentee after: Chengdu Diao Group Tianfu Medicine Co., Ltd. Address before: 610021 Sichuan city of Chengdu Province, North Bridge Road No. 14 military retired cadres Patentee before: Liu Mosen |
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Expiration termination date: 20101008 Granted publication date: 19930113 |