CN1899574A - Chinese medicine composition for preventing and controlling liver cancer and its use - Google Patents
Chinese medicine composition for preventing and controlling liver cancer and its use Download PDFInfo
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- CN1899574A CN1899574A CN 200610052245 CN200610052245A CN1899574A CN 1899574 A CN1899574 A CN 1899574A CN 200610052245 CN200610052245 CN 200610052245 CN 200610052245 A CN200610052245 A CN 200610052245A CN 1899574 A CN1899574 A CN 1899574A
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Abstract
The present invention discloses a kind of Chinese medicine composition prepared with 12 kinds of Chinese medicinal materials and its application. The preparation process includes the following steps: reflux extracting astragalus root, red sage and other three kinds of Chinese medicinal materials in certain weight proportion in 70-95 % alcohol solution and concentrating to obtain extractum I; twice water decocting yangtao actinidia root, barbat skullcap and other five kinds of Chinese medicinal materials in certain weight proportion and the alcohol extracted residue and concentrating to obtain extractum II; merging the extractum I and the extractum II and crushing the mixture to obtain the active medicine components; and further preparing granule. The Chinese medicine composition has the functions of supporting the healthy energy, promoting blood circulation to disperse blood clots, clearing away heat and toxic material, promoting diuresis and eliminating swelling, and possesses high curative effect on liver cancer, no adverse reaction and other advantages.
Description
Technical field
The present invention relates to field of medicaments, is a kind of Chinese medicine composition and application thereof that prevents and treats hepatocarcinoma specifically
Background technology
Hepatocarcinoma is a kind of one of human dead main disease that causes, and does not have specific drug and specific treatment method temporarily a few days ago.The operation of doctor trained in Western medicine can be excised rapidly early, mid-term cancer, but often recurrence easily; Simultaneously, to a patient who suffers from hepatocarcinoma, operation technique can emit lethal danger, because he also suffers from quite serious hepatitis interstitialis chronica, though if use good anticancer preparation in the case is a better Therapeutic Method. radiotherapy can make cancer cell atrophy, degeneration, but can only carry out topical therapeutic, and the accommodator only accounts for 20%; Though chemotherapy can be carried out whole body therapeutic, patient often seriously can't persevere because of toxic and side effects and untoward reaction.In order to solve the deficiency of above-mentioned technology, the present invention is through scientific composition, and development provides a kind of Chinese medicine anticancer preparation and preparation method thereof meticulously.It can be cured the disease, again can diseases prevention, and therapeutic effect is good, and patient Le Yi accepts.Simultaneously, fatty liver and hepatitis interstitialis chronica are also had good prevention effect, can treat hepatocarcinoma effectively and stop the development of hepatocarcinoma.
Summary of the invention
The purpose of this invention is to provide a kind of pure Chinese medicinal preparation for the treatment of hepatocarcinoma.It follows the principle of the traditional Chinese medical science " sthenia syndrome requiring purgation " and " deficiency syndrome should be treated by tonifying method ", effect with strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, inducing diuresis to remove edema, aim to provide and a kind ofly can either play fine treatment or relief of symptoms effect hepatocarcinoma, have good effect, the cycle is short, price is low, do not have any untoward reaction, is a kind of anticancer traditional Chinese medicine composition that the patient takes like a shot.It all has good effect to all kinds of hepatocarcinoma of early, middle and late phase.
The present invention develops Chinese medicine composition meticulously according to traditional Chinese medical science prescription and preparation principle, realizes by following technical scheme:
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains:
166～498 parts of 166～498 parts of Radix vitis romanetiis of 331～999 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Radix Actinidiae Chinensis
166～498 parts of 166～498 parts of Rhizoma Imperataes of 166～498 portions of Herba Lobeliae Chinensis of Herba Scutellariae Barbatae
166～498 parts of 166～998 portions of Radix Curcumaes of 166～998 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
166～498 parts of 166～498 parts of Herba Hedyotidis Diffusaes of Rhizoma Cyperi, 166～998 Fructus Adinaes
Preferable range is:
248～498 parts of 248～498 parts of Radix vitis romanetiis of 331～999 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Radix Actinidiae Chinensis
166～498 parts of 166～498 parts of Rhizoma Imperataes of 166～498 portions of Herba Lobeliae Chinensis of Herba Scutellariae Barbatae
166～498 parts of 666～998 portions of Radix Curcumaes of 666～998 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
166～498 parts of 166～498 parts of Herba Hedyotidis Diffusaes of Rhizoma Cyperi, 666～998 Fructus Adinaes
Optimum weight part is:
333 parts of 666 parts of Radix vitis romanetiis of 666 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Radix Actinidiae Chinensis
222 parts of 222 parts of Rhizoma Imperataes of 222 portions of Herba Lobeliae Chinensis of Herba Scutellariae Barbatae
333 parts of 888 portions of Radix Curcumaes of 888 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
222 parts of 222 parts of Herba Hedyotidis Diffusaes of Rhizoma Cyperi, 666 Fructus Adinaes
Inventing technical problem to be solved is to realize by following technical scheme.Be characterized in that with Radix Actinidiae Chinensis, Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix vitis romanetii, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Rhizoma Imperatae, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Fructus Adinae etc. be the medicine that raw material is made.The Chinese medicine composition of this treatment hepatocarcinoma is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.The present invention is by scientific combination, development meticulously, effect with strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, inducing diuresis to remove edema, can play fine treatment or relief of symptoms effect to hepatocarcinoma, have good effect, the cycle is short, price is low, do not have any untoward reaction, is a kind of anticancer traditional Chinese medicine composition that the patient takes like a shot.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made peroral dosage form then; But, preferably the crude drug Radix Astragali, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, Herba Hedyotidis Diffusae are carried out ethanol extraction, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine better bring into play drug effect.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation method of granule of the present invention: medicine of the present invention can prepare by the following method:
(a) take by weighing former medicine such as Radix Actinidiae Chinensis 666 gram, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 666 grams, Radix vitis romanetii 333 gram Herba Scutellariae Barbataes 222 grams, Herba Lobeliae Chinensis 222 grams, Rhizoma Imperatae 222 grams, the Radix Astragali 888 grams, Radix Salviae Miltiorrhizae 888 gram Radix Curcumaes 333 grams, Rhizoma Cyperi 222 grams, Herba Hedyotidis Diffusae gram, Fructus Adinae 222 grams and that coarser powder is ground in its pulverizing is standby by weight ratio;
(b) Radix Astragali, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, the Herba Hedyotidis Diffusae with described weight proportion carries out reflux, extract, twice with 70%～95% ethanol, merge extracted twice liquid, reclaim ethanol, be condensed into proportion and be 1.15～1.35 extractum, dry under 45～55 ℃, get dry extract 1;
(c) residue after Radix Actinidiae Chinensis, Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix vitis romanetii, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Rhizoma Imperatae, Fructus Adinae and the Radix Astragali of described weight proportion, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, the Herba Hedyotidis Diffusae alcohol extraction is decocted with water twice, add water serves as easy not have powder at every turn, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, the active component of preparation cost invention medicine;
(e) with gained active component and pharmaceutically acceptable additives such as correctives, the abundant mixing of adjuvant, make any dosage form of pharmaceutics.As above-mentioned active component was pulverized 100 mesh sieves, with pharmaceutically acceptable additives such as mixings such as ethanol, starch, moistening, soften, take out when forming agglomerate, make dissolved granule.
In the above-mentioned preparation method, when in the preferred steps (b) medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, and add amount of alcohol the second time is 10 times, extracts 1 hour.(c) during with the medicine extracting in water, add 10 times in water for the first time in, decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours.
Embodiment 2:
The preparation method of syrup of the present invention: with Radix Actinidiae Chinensis 666 grams, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 666 grams, Radix vitis romanetii 333 grams, Herba Scutellariae Barbatae 222 grams, Herba Lobeliae Chinensis 222 grams, Rhizoma Imperatae 222 grams, the Radix Astragali 888 grams, Radix Salviae Miltiorrhizae 888 grams, Radix Curcumae 333 grams, Rhizoma Cyperi 222 grams, Herba Hedyotidis Diffusae 888 grams, Fructus Adinae 222 gram decocting secondaries, each 2 hours, filter, merging filtrate, be condensed into thick paste, add the ethanol precipitation secondary, make and contain pure flow control and once reach 65%, for the second time reach 80%, filter, reclaim ethanol and be concentrated into about 700mL, while hot with sucrose, ethyl hydroxybenzoate alcohol liquid stirs molten, add boiling water again to full dose, stir evenly promptly to get and make syrup.
Embodiment 3:
The preparation method of tablet of the present invention:
The broken coarser powder that grind into of former medicated powder such as Radix Actinidiae Chinensis 666 grams, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 666 grams, Radix vitis romanetii 333 grams, Herba Scutellariae Barbatae 222 grams, Herba Lobeliae Chinensis 222 grams, Rhizoma Imperatae 222 grams, the Radix Astragali 888 grams, Radix Salviae Miltiorrhizae 888 grams, Radix Curcumae 333 grams, Rhizoma Cyperi 222 grams, Herba Hedyotidis Diffusae 888 grams, Fructus Adinae 222 grams is standby; After making granule by example 1 method, add an amount of additives, mixing, tabletting, coating are made suitable tablet.
In like manner, press the method for embodiment 1, add suitable capsule etc.
Preparation of the present invention is fragrant faint yellow granule, sepia syrup or tablet or capsule.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
For a better understanding of the present invention, below further set forth the action effect of medicine of the present invention in pharmacology and clinical research, but not to the restriction of effect of the present invention.
Selection of clinical is observed 30 routine liver cancer patients, is divided into 2 groups, every group 15 example.Matched group adopts the TIANXIAN WAN treatment, and the treatment group adopts the treatment of this medicine.Clinical effectiveness is as follows:
| Clinical | Effectively | Produce effects | Invalid | Total effective rate (%) |
| Treatment group matched group | 8 6 | 5 4 | 2 5 | 86.67 66.67 |
According to above clinical pharmacology result of study, the present invention has the effect of strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, inducing diuresis to remove edema really, can play fine treatment or relief of symptoms effect to hepatocarcinoma, have good effect, the cycle is short, price is low, do not have any untoward reaction, patient's medication is convenient, economical, only be equivalent to 25% of chemotherapeutics expense, can be continuously, long-term prescription and be unlikely to produce the toxic and side effects of organ injuries such as bone marrow depression, granulocytopenia, liver and kidney; All kinds of hepatocarcinoma of early, middle and late phase are all had good effect, are a kind of active drugs of preventing and treating hepatocarcinoma that the patient takes like a shot.
Claims (8)
1, a kind of Chinese medicine composition for the treatment of hepatocarcinoma is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials: the consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
166～498 parts of 166～498 parts of Radix vitis romanetiis of 331～999 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Radix Actinidiae Chinensis
166～498 parts of 166～498 parts of Rhizoma Imperataes of 166～498 portions of Herba Lobeliae Chinensis of Herba Scutellariae Barbatae
166～498 parts of 166～998 portions of Radix Curcumaes of 166～998 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
166～498 parts of 166～498 parts of Herba Hedyotidis Diffusaes of Rhizoma Cyperi, 166～998 Fructus Adinaes
2, pharmaceutical composition according to claim 1 is characterized in that the formula optimization scope is:
248～498 parts of 248～498 parts of Radix vitis romanetiis of 331～999 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Radix Actinidiae Chinensis
166～498 parts of 166～498 parts of Rhizoma Imperataes of 166～498 portions of Herba Lobeliae Chinensis of Herba Scutellariae Barbatae
166～498 parts of 666～998 portions of Radix Curcumaes of 666～998 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
166～498 parts of 166～498 parts of Herba Hedyotidis Diffusaes of Rhizoma Cyperi, 666～998 Fructus Adinaes
3, pharmaceutical composition according to claim 1, optimum weight part is:
333 parts of 666 parts of Radix vitis romanetiis of 666 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Radix Actinidiae Chinensis
222 parts of 222 parts of Rhizoma Imperataes of 222 portions of Herba Lobeliae Chinensis of Herba Scutellariae Barbatae
333 parts of 888 portions of Radix Curcumaes of 888 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
222 parts of 222 parts of Herba Hedyotidis Diffusaes of Rhizoma Cyperi, 666 Fructus Adinaes
4, pharmaceutical composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, dried starch, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate.
5, preparation of drug combination method as claimed in claim 1 is characterized in that comprising the steps:
(a) take by weighing former medicines such as Radix Actinidiae Chinensis, Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix vitis romanetii, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Rhizoma Imperatae, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Fructus Adinae and that coarser powder is ground in its pulverizing is standby by the optimum weight proportioning;
(b) Radix Astragali, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, the Herba Hedyotidis Diffusae with described weight proportion carries out reflux, extract, twice with 70%～95% ethanol, merge extracted twice liquid, reclaim ethanol, be condensed into proportion and be 1.15～1.35 extractum, dry under 45～55 ℃, get dry extract 1;
(c) residue after Radix Actinidiae Chinensis, Radix Apioris Fortunei (Radix Lespedezae Buergeri), Radix vitis romanetii, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Rhizoma Imperatae, Fructus Adinae and the Radix Astragali of described weight proportion, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, the Herba Hedyotidis Diffusae alcohol extraction is decocted with water twice, add water serves as easy not have powder at every turn, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, the active component of preparation cost invention medicine;
(e) with gained active component and pharmaceutically acceptable additives such as correctives, the abundant mixing of adjuvant, make any dosage form of pharmaceutics.As above-mentioned active component was pulverized 100 mesh sieves, with pharmaceutically acceptable additives such as mixings such as ethanol, starch, moistening, soften, take out when forming agglomerate, make dissolved granule.
6, by in the above-mentioned preparation method of claim 5, when in the preferred steps (b) medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, and add amount of alcohol the second time is 10 times, extracts 1 hour.Spissated extractum proportion is 1.15.
7, by in the above-mentioned preparation method of claim 5, during with the medicine extracting in water, add 10 times in water for the first time in the preferred steps (c), decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours.Spissated extractum proportion is 1.20.
8, pharmaceutical composition according to claim 1 is characterized in that: its dosage form can be a said dosage form on any pharmaceutics, as effervescent granule electuary, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700323B (en) * | 2009-10-30 | 2014-02-12 | 浙江医药高等专科学校 | A pharmaceutical composition for preventing and treating liver cancer |
| CN107080767A (en) * | 2017-03-28 | 2017-08-22 | 杭州本草中药有限公司 | Purposes of the radix tetrastigme general flavone in treatment anti-hepatic fibrosis medicines |
| CN109260325A (en) * | 2018-08-27 | 2019-01-25 | 辽宁中医药大学 | A kind of point-application ointment and preparation method thereof |
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2006
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700323B (en) * | 2009-10-30 | 2014-02-12 | 浙江医药高等专科学校 | A pharmaceutical composition for preventing and treating liver cancer |
| CN107080767A (en) * | 2017-03-28 | 2017-08-22 | 杭州本草中药有限公司 | Purposes of the radix tetrastigme general flavone in treatment anti-hepatic fibrosis medicines |
| CN109260325A (en) * | 2018-08-27 | 2019-01-25 | 辽宁中医药大学 | A kind of point-application ointment and preparation method thereof |
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