CN102940747A - Medicine composition for treating gout - Google Patents
Medicine composition for treating gout Download PDFInfo
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- CN102940747A CN102940747A CN2012104286920A CN201210428692A CN102940747A CN 102940747 A CN102940747 A CN 102940747A CN 2012104286920 A CN2012104286920 A CN 2012104286920A CN 201210428692 A CN201210428692 A CN 201210428692A CN 102940747 A CN102940747 A CN 102940747A
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Abstract
The invention discloses a medicine composition for treating gout, comprising Astragalus mongholicus, epimedium, ginger processed pinellia and Chinese yam. The medicine composition disclosed herein can quickly alleviate clinical symptoms of patients and has the advantages of low price and no side effect.
Description
Technical field
The present invention relates to medical technical field, relate to or rather the pharmaceutical composition for the treatment of gout.
Background technology
Gout claims again hyperuricemia, and sickness rate is high, healing is difficult, repeatedly outbreak, belongs to the metabolic disease that the purine metabolism obstacle causes.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, its clinical characters is that hyperuricemia and the gouty acute arthritis that causes are thus shown effect repeatedly, tophus deposition, tophus chronic arthritis and joint deformity etc., dumb as main clinical manifestation take redness and swelling of joints, burning pain, repeatedly outbreak, joint motion.Often involve kidney and cause that chronic interstitial nephritis and uric acid renal calculus form.Increase reason according to uric acid in the blood and can be divided into constitutional and Secondary cases two large classes.The cause of disease of primary gout is owing to due to the congenital purine metabolic disturbance, belong to heritability.The cause of disease of secondary gout can be caused by many reasons such as nephropathy, leukemia, medicine, foods, is apt to occur in male and menopausal woman.Gout belongs to Chinese medicine " arthromyodynia " category." treatise on blood trouble ": " gout, general numbness and hypoesthesia, limbs pain, modern name gout, Gu are said arthromyodynia ".
The Western medicine that is used for the treatment of at present gout mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only be stablized the state of an illness mostly, can not effect a radical cure gout; Can cause that also serious side effect causes the infringement of hepatic and renal function; Even Emergent therapy effectively can not be controlled disease relapse, and can produce drug resistance and repellence, even leukopenia can appear, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes.Increasing expert thinks: from the organic conception of the traditional Chinese medical science, execute with the Chinese medicine integral syndrome differentiation and to control, can yet be regarded as and treat another good footpath of gout; Not only the toxic and side effects of Chinese medicine itself greatly reduces, and can reduce the Western medicine dose, overcomes to take merely the huge toxic and side effects that Western medicine brings for a long time.But the Chinese patent medicine for the treatment of in the market gout is few, and curative effect lacks preferably especially, and the patient still can only stablize the state of an illness by taking in a large number the larger Western medicine of toxic and side effects.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition gout, determined curative effect for the treatment of.This medicine composite for curing gout is with strong points, and curative effect is better, and side effect is little, and safety is good.
To achieve these goals, technical scheme provided by the invention is:
A kind of pharmaceutical composition for the treatment of gout, it is to be the medicament that medicinal raw material is made by the Radix Astragali, Herba Epimedii, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and Rhizoma Dioscoreae.
The weight proportion of the used medicine material of pharmaceutical composition of the present invention can be Radix Astragali 9-21 part, Herba Epimedii 8-18 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3-15 part, Rhizoma Dioscoreae 3-15 part.
The more preferably proportioning of the used medicine material of pharmaceutical composition of the present invention is: Radix Astragali 12-18 part, Herba Epimedii 9-15 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6-12 part, Rhizoma Dioscoreae 6-12 part.
The best proportioning of the used medicine material of pharmaceutical composition of the present invention is: 15 parts of the Radixs Astragali, 12 parts of Herba Epimedii, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 8 parts of Rhizoma Dioscoreaes.
The pharmaceutical composition of above-mentioned treatment gout can be made the medicine of any one suitable on pharmaceutics dosage form, preferred granulation agent, tablet, hard capsule, oral liquid, soft capsule, drop pill etc. with each crude drug after treatment according to the formulation method of routine.
According to the needs of the various drug forms of preparation, pharmaceutical composition of the present invention can adopt and can adopt but be not limited to following methods:
(1) gets Milkvetch Root by formula proportion, 60% alcohol reflux of 10 times of volumes of adding three times, extraction time is respectively 2.0,1.5,1.5h, collects merge extractive liquid, and concentrated, in the extracting solution after concentrated, thin up, staticly settle, filter, get supernatant concentration and become rare extractum, drying obtains Radix Astragali extract.
(2) get epimedium herb, 95% ethanol extraction of 6 times of volumes of adding 3 times, each 1h collects merge extractive liquid, and also suitably concentrates, and divides 3 extractions with ethyl acetate, merges the ethyl acetate layer of extraction, and is dry behind the recovery solvent, gets Herba Epimedii extract.
(3) get the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medical material by formula proportion, add 85% alcohol reflux 3h of 10 times of volumes, collect extracting solution, the centrifugal precipitation of removing, the vacuum drying supernatant obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(4) get the Rhizoma Dioscoreae defibrination, add the water of 10 times of volumes, regulate pH to 7-9 with 30%NaOH solution, 2h is extracted in constant temperature (60-80 ℃) water-bath, centrifugal (3000r/min, 15min) collects supernatant, and the water that again adds 8 times of volumes in the precipitation extracts, centrifugal collection supernatant, concentrating under reduced pressure (60 ℃) after mixing, 4 ℃ of 70% ethanol that add 1 times of volume leave standstill 12h, centrifugal (3000r/min, 30min) collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(5) above-mentioned each extract is mixed, make acceptable various pharmaceutical dosage form.
According to the needs of the various drug forms of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant such as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
The used various raw medicinal materials of the present invention are the Chinese crude drug that meets country or provincial standard regulation.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention treats in the pharmaceutical composition of gout, and Radix Astragali nature and flavor are sweet, warm, returns lung meridian, spleen channel, has invigorating QI to consolidate the body surface resistance, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, the function of expelling pus and promoting granulation; Herba Epimedii acrid in the mouth, sweet, warm in nature, return liver, kidney channel, have the function of kidney invigorating and YANG supporting, expelling wind and removing dampness, strong muscle key bone, modern pharmacological research shows that Herba Epimedii has resisting pathogenic microbes effect antiinflammatory action; The Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) acrid in the mouth, warm in nature, poisonous, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass; The Rhizoma Dioscoreae sweet in the mouth, the function that property is flat to have spleen reinforcing, support lung, reinforce the kidney, benefit is smart.More than 4 flavor Chinese medicine composition use, have the Synergistic function, be used for the treatment of gout, determined curative effect shows through clinical research, it is better that medicine of the present invention is used for the treatment of the gout curative effect, and do not find obvious side effect and untoward reaction.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment 1
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 15g, Herba Epimedii 12g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10g, Rhizoma Dioscoreae 8g.
As follows granulation agent: get the crude drug of described proportioning, add respectively suitable quantity of water, adopt decocting method to extract respectively 2 times, filter, merges 2 times filtrate, concentrated after with each concentrated solution mix homogeneously, drying is distributed into after the granulation bag and get final product.
Embodiment 2
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 15g, Herba Epimedii 12g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10g, Rhizoma Dioscoreae 8g.
As follows granulation agent: get the crude drug of described proportioning, add respectively an amount of 70% ethanol, adopt reflux extraction to extract respectively 3 times, filter, merge 3 times filtrate, Recycled ethanol and concentrate after with each concentrated solution mix homogeneously, drying, be distributed into after the granulation bag and get final product.
Embodiment 3
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 15g, Herba Epimedii 12g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10g, Rhizoma Dioscoreae 8g.
By the following method granulation agent:
(1) gets Milkvetch Root by formula proportion, 60% alcohol reflux of 10 times of volumes of adding three times, extraction time is respectively 2.0,1.5,1.5h, collects merge extractive liquid, and concentrated, in the extracting solution after concentrated, thin up, staticly settle, filter, get supernatant concentration and become rare extractum, drying obtains Radix Astragali extract.
(2) get epimedium herb, 95% ethanol extraction of 6 times of volumes of adding 3 times, each 1h collects merge extractive liquid, and also suitably concentrates, and divides 3 extractions with ethyl acetate, merges the ethyl acetate layer of extraction, and is dry behind the recovery solvent, gets Herba Epimedii extract.
(3) get the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medical material by formula proportion, add 85% alcohol reflux 3h of 10 times of volumes, collect extracting solution, the centrifugal precipitation of removing, the vacuum drying supernatant obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(4) get the Rhizoma Dioscoreae defibrination, the water that adds 10 times of volumes, regulate pH to 9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in 70 ℃ of water-baths of constant temperature, the water that again adds 8 times of volumes in the precipitation extracts, centrifugal collection supernatant mixes rear 60 ℃ of concentrating under reduced pressure, and 4 ℃ of 70% ethanol that add 1 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(5) get above-mentioned each extract and mix evenly, drying is distributed into bag after the granulation, the granulation agent.
Embodiment 4
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 9g, Herba Epimedii 8g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3g, Rhizoma Dioscoreae 3g.
Be prepared into by the following method soft capsule:
(1) gets Milkvetch Root by formula proportion, 95% alcohol reflux of 8 times of volumes of adding three times, extraction time is respectively 2.0,1.5,1.5h, collects merge extractive liquid, and concentrated, in the extracting solution after concentrated, thin up, staticly settle, filter, get supernatant concentration and become rare extractum, drying obtains Radix Astragali extract.
(2) get epimedium herb, 95% ethanol extraction of 6 times of volumes of adding 3 times, each 1h collects merge extractive liquid, and also suitably concentrates, and divides 3 extractions with ethyl acetate, merges the ethyl acetate layer of extraction, and is dry behind the recovery solvent, gets Herba Epimedii extract.
(3) get the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medical material by formula proportion, add 85% alcohol reflux 3h of 8 times of volumes, collect extracting solution, the centrifugal precipitation of removing, the vacuum drying supernatant obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(4) get the Rhizoma Dioscoreae defibrination, the water that adds 10 times of volumes, regulate pH to 9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in constant temperature (60-80 ℃) water-bath, the water that again adds 8 times of volumes in the precipitation extracts, centrifugal collection supernatant, concentrating under reduced pressure (60 ℃) after mixing, 4 ℃ of 70% ethanol that add 0.3 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(5) above-mentioned each extract is mixed, add vegetable oil 25g, mixing is made capsule casing material with gelatin, is pressed into soft capsule.
Embodiment 5
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 21g, Herba Epimedii 18g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15g, Rhizoma Dioscoreae 15g.
(1) gets Milkvetch Root by formula proportion, the ethanol of 8 times of volumes of adding or water reflux, extract, three times, extraction time is respectively 2.0,1.5,1.5h, collects merge extractive liquid, and concentrated, in the extracting solution after concentrated, thin up, staticly settle, filter, get supernatant concentration and become rare extractum, drying obtains Radix Astragali extract.
(2) get epimedium herb, 60% ethanol extraction of 6 times of volumes of adding 3 times, each 2h collects merge extractive liquid, and also suitably concentrates, and divides 3 extractions with ethyl acetate, merges the ethyl acetate layer of extraction, and is dry behind the recovery solvent, gets Herba Epimedii extract.
(3) get the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medical material by formula proportion, add 85% alcohol reflux 3h of 10 times of volumes, collect extracting solution, the centrifugal precipitation of removing, the vacuum drying supernatant obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(4) get the Rhizoma Dioscoreae defibrination, the water that adds 8 times of volumes, regulate pH to 7 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in 60 ℃ of water-baths of constant temperature, the water that again adds 4 times of volumes in the precipitation extracts, centrifugal collection supernatant, concentrating under reduced pressure after mixing, 4 ℃ of 70% ethanol that add 0.3 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(5) above-mentioned each extract is dissolved in the 1000mL water for injection, adopts existing preparation of injection, make injectable powder.
Embodiment 6
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 12g, Herba Epimedii 15g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Rhizoma Dioscoreae 12g.
Aforementioned pharmaceutical compositions is prepared into capsule:
(1) gets Milkvetch Root by formula proportion, the water reflux, extract, of 10 times of volumes of adding three times, extraction time is respectively 2.0,1.5,1.5h, collects merge extractive liquid, and concentrated, in the extracting solution after concentrated, thin up, staticly settle, filter, get supernatant concentration and become rare extractum, drying obtains Radix Astragali extract.
(2) get epimedium herb, 60% ethanol extraction of 10 times of volumes of adding 3 times, each 2h collects merge extractive liquid, and also suitably concentrates, and divides 3 extractions with ethyl acetate, merges the ethyl acetate layer of extraction, and is dry behind the recovery solvent, gets Herba Epimedii extract.
(3) get the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medical material by formula proportion, add 85% alcohol reflux 3h of 10 times of volumes, collect extracting solution, the centrifugal precipitation of removing, the vacuum drying supernatant obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(4) get the Rhizoma Dioscoreae defibrination, the water that adds 10 times of volumes, regulate pH to 9 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in constant temperature (60 ℃) water-bath, the water that again adds 8 times of volumes in the precipitation extracts, centrifugal collection supernatant mixes rear 60 ℃ of concentrating under reduced pressure, and 4 ℃ of 70% ethanol that add 1 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(5) with above-mentioned each extract and starch 100g mix homogeneously, adopt capsules preparation technique, make capsule.
Embodiment 7
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 12g, Herba Epimedii 9g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Rhizoma Dioscoreae 6g.
Above-mentioned medicinal raw material is prepared into tablet:
(1) gets Milkvetch Root by formula proportion, the ethanol of 10 times of volumes of adding or water reflux, extract, three times, extraction time is respectively 2.0,1.5,1.5h, collects merge extractive liquid, and concentrated, in the extracting solution after concentrated, thin up, staticly settle, filter, get supernatant concentration and become rare extractum, drying obtains Radix Astragali extract.
(2) get epimedium herb, 95% ethanol extraction of 10 times of volumes of adding 3 times, each 2h collects merge extractive liquid, and also suitably concentrates, and divides 3 extractions with ethyl acetate, merges the ethyl acetate layer of extraction, and is dry behind the recovery solvent, gets Herba Epimedii extract.
(3) get the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) medical material by formula proportion, add 85% alcohol reflux 3h of 10 times of volumes, collect extracting solution, the centrifugal precipitation of removing, the vacuum drying supernatant obtains Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) extract.
(4) get the Rhizoma Dioscoreae defibrination, the water that adds 10 times of volumes, regulate pH to 7 with 30%NaOH solution, 2h, centrifugal collection supernatant are extracted in 60 ℃ of water-baths of constant temperature, the water that again adds 4 times of volumes in the precipitation extracts, centrifugal collection supernatant mixes rear 60 ℃ of concentrating under reduced pressure, and 4 ℃ of 70% ethanol that add 0.5 times of volume leave standstill 12h, centrifugal collecting precipitation, 40 ℃ of vacuum dryings get Rhizoma Dioscoreae extract.
(5) above-mentioned each extract is mixed evenly drying, tabletting and get final product after granulating.
Embodiment 8
The pharmaceutical composition of the treatment gout that present embodiment is enumerated is comprised of the medicinal raw material of following weight:
Radix Astragali 18g, Herba Epimedii 15g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12g, Rhizoma Dioscoreae 12g.
Make as follows capsule: get the crude drug of described proportioning, mix, add suitable quantity of water, adopt decocting method to extract 2 times, filter, merges 2 times filtrate, concentrate, drying is in the hungry area softgel shell of packing into after the granulation and get final product.
The various embodiments described above medicine, also can be according to other conventional formulation method, with each crude drug of corresponding weight proportion through other extract and the method processing such as purification after, make again the medicine of other dosage form, as: granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill, honeyed pill etc.
In addition, according to the needs of the various drug forms of preparation, the various embodiments described above medicine also can add suitable pharmaceutic adjuvant such as magnesium stearate, starch, dextrin, sucrose, microcrystalline Cellulose, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc. in preparation process.
Test example
For the efficacy and saferry of proved invention medicine, the inventor has carried out pharmacodynamics and toxicity test is investigated.The research method and the result of the test that adopt are as follows:
(1) pharmacodynamics test research
1, test material
(1), medicine and reagent:
The extract of medicine of the present invention for making according to embodiment 4 described crude drug weight proportions and method.
Colchicine is Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2), animal: Kunming mouse, SD rat are provided by institute of antibiotics, Sichuan Experimental Animal Center.
2, test method and result
(1) on the impact of hyperuricemia Mouse Blood uric acid level
Get 60 of Kunming mouses, male and female are all used, body weight 18～22g, be divided at random normal saline group, medicine low dose group of the present invention (dosage group in 4g raw medicinal herbs/kg), the medicine of the present invention (8g raw medicinal herbs/kg), medicine high dose group of the present invention (16g raw medicinal herbs/kg), positive controls, gavage respectively normal saline, medicine of the present invention and colchicine, every day 1 time, continuously 4d.Behind the last administration 1h, except the normal saline group, all the other each treated animal Intraperitoneal injection of hypoxanthine 1mg/kg cause the mice hyperuricemia, the capacity blank liquid such as normal saline group injection.0.5h after the injection, each treated animal is plucked eyeball and is got blood, and the centrifugal 15min of 3000r/min gets serum and surveys Level of Serum Uric Acid.
Table 1 is on the impact of hyperuricemia Mouse Blood uric acid level
Annotate: compare with model group: * * P＜0.01
As can be seen from the table, each group of the high, medium and low dosage of medicine of the present invention all can reduce the Mouse Blood uric acid level, with model group significant difference is arranged relatively.
Claims (4)
1. the pharmaceutical composition of a gout is characterized in that: it is to be the medicament that medicinal raw material is made by the Radix Astragali, Herba Epimedii, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and Rhizoma Dioscoreae.
2. pharmaceutical composition according to claim 1, it is characterized in that: it is to be made by the crude drug of following weight parts proportioning:
Radix Astragali 9-21 part, Herba Epimedii 8-18 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3-15 part, Rhizoma Dioscoreae 3-15 part.
3. Chinese medicine composition according to claim 1, it is characterized in that: the weight portion proportioning of described each crude drug is:
Radix Astragali 12-18 part, Herba Epimedii 9-15 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6-12 part, Rhizoma Dioscoreae 6-12 part.
4. Chinese medicine composition according to claim 2, it is characterized in that: the weight portion proportioning of described each crude drug is:
15 parts of the Radixs Astragali, 12 parts of Herba Epimedii, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 8 parts of Rhizoma Dioscoreaes.
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| CN201210428692.0A CN102940747B (en) | 2012-10-31 | 2012-10-31 | Medicine composition for treating gout |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435567A (en) * | 2014-11-07 | 2015-03-25 | 成都华熹科技有限公司 | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout |
| CN106177297A (en) * | 2016-08-30 | 2016-12-07 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating gout |
-
2012
- 2012-10-31 CN CN201210428692.0A patent/CN102940747B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
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| 刘健: "痛风的中医药调治", 《健康报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435567A (en) * | 2014-11-07 | 2015-03-25 | 成都华熹科技有限公司 | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout |
| CN106177297A (en) * | 2016-08-30 | 2016-12-07 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating gout |
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Effective date of registration: 20171207 Address after: 510430 stone Xia Road, Huangshi street, Baiyun District, Guangzhou, Guangdong Province, No. 1 Patentee after: Guangzhou Baiyun District Guang'an gout prevention and Control Research Institute Address before: 226131 Jiangsu city of Nantong Province Haimen Yuelai town Fuxing Road, building 12, the town government compound Patentee before: Nantong Yue Yue Industrial Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140702 Termination date: 20181031 |