CN104823985B - A kind of bactericidal composition containing pyridine bacterium azoles and application thereof - Google Patents
A kind of bactericidal composition containing pyridine bacterium azoles and application thereof Download PDFInfo
- Publication number
- CN104823985B CN104823985B CN201510228880.2A CN201510228880A CN104823985B CN 104823985 B CN104823985 B CN 104823985B CN 201510228880 A CN201510228880 A CN 201510228880A CN 104823985 B CN104823985 B CN 104823985B
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- Prior art keywords
- bacterium azoles
- bactericidal composition
- agent
- pyridine
- pyrrole fluorine
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
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- 229960003212 sodium propionate Drugs 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing pyridine bacterium azoles, its effective ingredient is pyridine bacterium azoles and pyrrole fluorine bacterium ester, and both mass ratioes are 1:50～50:1.Compositions has obvious potentiation, and safety is good, it is adaptable to preventing and treating vegetable, fruit tree, cereal crop powdery mildew.
Description
Technical field
The present invention relates to a kind of bactericidal composition, the application of especially a kind of bactericidal composition containing pyridine bacterium azoles and preventing and treating corps diseases thereof, belong to technical field of pesticide.
Background technology
Powdery mildew is the worldwide disease of a kind of extensive generation, the Erysiphaceae in fungus cause.
In production, main employing chemical pesticide control powdery mildew, currently mainly relies on benzimidazole, triazole type, methoxy acrylic bactericide.These medicaments have created resistance in various degree because of life-time service, and prevention effect reduces.It addition, the growth of crop is had inhibitory action when using dosage is big by triazole type medicament, it is easy to cause poisoning.
Pyridine bacterium azoles (SYP-Z048), chemical name: N-methyl-3-(4-chlorine) phenyl-5-methyl-5-pyridine-3-methyl-azoles quinoline, molecular formula: C16H17ClN2O, the novel agrochemical kind independently formulated for Shenyang Chemical Engineering Inst and develop (Chinese invention patent number: CN99113093.6), it is a kind of oxazolines antibacterial, belongs to sterol synthetic inhibitor.This compound is used alone relatively costly and easy Induced resistance and produces, thus reducing service life.
Summary of the invention
It is an object of the invention to: a kind of Synergistic bactericidal composition being suitable for and agriculturally using is provided, and contributes to reducing dosage, delay pathogen produce resistance and reduce use cost.
For overcoming the deficiencies in the prior art, inventor is tested and field control effectiveness test by a large amount of indoor bioassay, have been surprisingly found that pyridine bacterium azoles and pyrrole fluorine bacterium ester with certain proportion composite after, powdery mildew is had significant synergies.
Pyrrole fluorine bacterium ester (ZJ2211), chemical name: 3-fluorine methoxyl group-2-[2-(3,5,6-trichloropyridine base-2-oxygen ylmethyl)-phenyl]-acrylic acid methyl ester., the QoI compounds with independent intellectual property right is developed for base, Zhejiang, pesticides discovery center, country south, apply for national inventing patent (CN1907024), be a kind of methoxy acrylic bactericide.By at CYB cl to the electron transfer of cytochrome C, thus suppressing mitochondrial breathing.The mechanism of action is different from pyridine bacterium azoles.
The technical scheme is that a kind of Synergistic bactericidal composition, it is characterised in that containing effective ingredient pyridine bacterium azoles and pyrrole fluorine bacterium ester, both mass ratioes are 1:50～50:1, it is preferable that mass ratio is 1:20～20:1, and more preferably mass ratio is 1:10～10:1.
In the bactericidal composition of the present invention, the mass accumulation percentage composition of effective ingredient is 5%～85%, all the other be auxiliary agent, filler and other be of value to effective ingredient at storage and stable and drug effect plays in using known substance.
The bactericidal composition of the present invention can be processed into any dosage form agriculturally allowed, and good dosage form has cream, suspending agent, aqueous emulsion, microemulsion, water dispersible granules or wettable powder.
Other composition in cream includes solvent, cosolvent and emulsifying agent；Other composition in suspending agent includes dispersant, wetting agent, emulsifying agent, defoamer, antifreezing agent, thickening agent, preservative and water；Other compositions in aqueous emulsion include solvent, emulsifying agent, antifreezing agent, defoamer and water；Other compositions in microemulsion include solvent, cosolvent, emulsifying agent and water；Other composition in water dispersible granules includes dispersant, wetting agent, diffusant, disintegrating agent and filler；Other composition in wettable powder includes dispersant, wetting agent, diffusant and filler.Below being all conventional in pesticidal preparations or permission use auxiliary element, be not particularly limited, concrete composition and consumption are determined by simple experiment according to recipe requirements.Such as:
Solvent may select one or more in isopropanol, dimethylbenzene, N,N-dimethylformamide, Ketohexamethylene, toluene, dimethyl sulfoxide, methanol, ethanol, trimethyl cyclic ethylene ketone, NOP, N-Methyl pyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, vegetable oil.
Cosolvent may select one or more in N-Methyl pyrrolidone, dimethylformamide, ethanol, Ketohexamethylene, isopropanol, the third ethanol, acetone.
Emulsifying agent may select agriculture breast 600#(phenethyl phenol polyethenoxy ether), agriculture breast 1601#(phenethyl phenol polyethenoxy polyethenoxy ether), agriculture breast 500#(calcium dodecyl benzene sulfonate), OP series phosphate ester (thermally coupled distillation columns), 600#Phosphate ester (phenyl phenol polyoxyethanyl ether phosphate), styrene polyoxyethylene rice ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, agriculture breast 400#(styryl formaldehyde resin polyoxyethylene ether), Nongru-700#(alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 36#(phenethyl fluosite polyoxyethyl ether), agriculture breast 1600#(phenethyl phenol polyethenoxy ether polyethenoxy ether), ethylene oxide-propylene oxide block copolymer, OP series (NPE), agriculture breast 33#(alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34#(alkylaryl polyoxyethylene poly-oxygen propylene aether), Span series (sorbitan monostearate), TWEEN Series (sorbitan fatty acid ester polyoxyethylene ether), AEO series (fat alcohol polyoxyethylenated alcohol) in one or more.
Dispersant may select sodium lignin sulfonate, calcium lignosulfonate, pull open in powder, calcium dodecyl benzene sulfonate, polycarboxylate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene ether one or more.
Wetting agent may select methyl naphthalene sulfonate formaldehyde condensate, sodium lauryl sulphate, Negel, alkyl benzene calcium sulfonate, tea seed cake, spaonin powder, Bombyx mori L., Fructus Sapindi Mukouossi powder, Laurel alcohol radical sodium sulfate, detergent, pull open in powder one or more.
Diffusant may select one or more in naphthalene sulfonate, poly-naphthalene formaldehyde sulfonate salt, organosilicon.
Antifreezing agent may select one or more in glycerol, carbamide, ethylene glycol, propylene glycol.
Defoamer may select one or more in metallic soap of stearic acid, polyureas, 20% aqueous emulsion of dimethyl polysiloxane fluid.
Preservative may select one or more in sodium benzoate, sodium propionate, butyl p-hydroxybenzoate, dimethyl fumarate, potassium sorbate, sodium diacetate.
Disintegrating agent may select one or more in ammonium sulfate, carbamide, bentonite, aluminum chloride, citric acid, succinic acid, sodium bicarbonate.
Thickening agent may select one or more in xanthan gum, hydroxymethyl cellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol.
Filler may select one or more in White Carbon black, Kaolin, precipitated calcium carbonate, Talcum, montmorillonite or convex-concave rod stone, Pumex, brickbat, meerschaum or bentonite and non-adsorbent calcium soil or sand.
Compositions described in the invention can provide with finished product preparation form, and namely in compositions, each material is blended；Can also provide with unit dose form, directly be mixed in proportion in bucket or tank before using, be then diluted to required concentration.
The bactericidal composition of the present invention can be used for preventing and treating various fungus-caused plant disease, is particularly well-suited to preventing and treating vegetable, fruit tree, cereal crop powdery mildew, such as powdery mildew of cucumber, uncinula necator, powdery mildew of strawberry, wheat powdery mildew.
The bactericidal composition of the present invention can be used by common method, such as leaching fruit, pouring root, smears, sprays, sprays, dusting, spread or be fuming, and its amount of application is with weather condition, Crop growing stage and disease occurrence degree calmly.
Compared with prior art, what the present invention produced has the beneficial effect that (1) compositions potentiation is obvious, and preventive effect significantly improves compared with single dose；(2), after drug effect improves, reduce field dosage and use cost, decrease pesticide residues and environmental pollution；(3) compositions is made up of the effective ingredient of different mechanism of action, and action site increases, and is conducive to overcoming and delay pathogenic bacteria to produce resistance.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearly understand, present invention specific examples below illustrates, but the present invention is limited to absolutely not these examples.
The pesticide active ingredient of different types of structure is carried out composite, is solve effective measures of the problem such as cost and resistance in pesticide single dose use procedure at present.After the pesticide active ingredient mixing of different types of structure, typically exhibit three kinds of type of action, i.e. summation action, potentiation and antagonism.But it is specially which kind of effect, it is impossible to prediction, only just be can know that by lot of experiments.The good formula of compound synergic, can improve actual prevention effect, reduces Pesticide use dosage, contributes to the generation of delaying drug resistance, is one of the important means of resistance management.
Powdery mildew of cucumber etc. is had obvious synergistic function by the present composition, and is not only that the simple of two kinds of pharmacy effects is added, and this can be clear that from the result that following Toxicity Determination is tested.Assays Example: pyridine bacterium azoles and the pyrrole composite Toxicity Determination to cucumber powdery mildew's pathogen of fluorine bacterium ester are tested
Subjects: cucumber powdery mildew's pathogen (Sphaerothecafuliginea (Sch.) Poll) (picks up from the wild powdery mildew of cucumber strain in field separated purification)
Test method: test, with reference to People's Republic of China (PRC) agricultural industry criteria NY/T1156.11-2008 " farm-chemical indoor determination test rule antibacterial the 11st part: preventing and treating cucurbits powdery mildew test pot-culture method ", adopts pot-culture method to measure.
Sowing susceptible cucumber variety, potted plant to grow to 2 leaf periods standby.Acetone solution used respectively by the pyrrole fluorine former medicine of bacterium ester and the former medicine of pyridine bacterium azoles, then dilutes with 0.1% tween 80 aqueous surfactant solution.Often process 3 basins, repeat for 4 times, 10ml medicinal liquid is uniformly sprayed on blade face to whole moistenings, treats that medicinal liquid dries naturally standby.And set containing only solvent and surfactant the process without effective ingredient and make blank.24h after chemicals treatment, spray inoculation cucumber powdery mildew's pathogen spore suspension.The process for preparation of spore suspension is as follows: takes and covers with Powdery Mildew cucumber leaves, is washed down by spore with the sterilized water added with a small amount of tween 80 surfactant, and double gauze filters, and is modulated into 1x10 after microscopy5The suspension of individual spore/milliliter.Inoculation is placed in thermostatic chamber, cultivates 7d under 24 DEG C of conditions of temperature.When blank disease leaf rate reaches more than 80%, incidence is managed in classification investigation everywhere, calculates disease index and the prevention effect of each process.
Prevention effect is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, concentration EC in calculating virulence equation with method of least square and suppress50, toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
The percentage composition of B in the percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] × 100
When CTC≤80, then compositions shows as antagonism, and as 80 < CTC < 120, then compositions shows as summation action, and when CTC >=120, then compositions shows as potentiation.Toxicity Determination result of the test refers to table 1.
Table 1 pyridine bacterium azoles and the composite Toxicity Determination result of the test to cucumber powdery mildew's pathogen of pyrrole fluorine bacterium ester
Result from table 1 is it can be seen that when pyridine bacterium azoles and pyrrole fluorine bacterium ester are between proportioning 1:50～50:1, co-toxicity coefficient (CTC) is all higher than 120, cucumber powdery mildew's pathogen is shown as potentiation, especially, time between 1:10～10:1, co-toxicity coefficient is all higher than 155, and potentiation is the most obvious.
Bactericidal composition of the present invention can prepare into, by known method, the cream, suspending agent, aqueous emulsion, microemulsion, water dispersible granules or the wettable powder that are suitable for agriculturally using.The following stated is only the good embodiment of the present invention, only in order to explain the present invention, therefore can not be interpreted as the restriction to the scope of the claims of the present invention.
Cream embodiment
Active component, solvent, cosolvent and emulsifying agent etc. being added in certain sequence in preparation still, stirring reaches certain index and namely makes missible oil product.
Example of formulations 1,21% pyridine bacterium azoles pyrrole fluorine bacterium emulsifiable concentrate
Pyridine bacterium azoles 20%, pyrrole fluorine bacterium ester 1%, phenethyl phenol polyethenoxy polyethenoxy ether (emulsifying agent) 4.5%, alkyl phenol formaldehyde resin polyoxyethylene ether (emulsifying agent) 2%, calcium dodecyl benzene sulfonate (emulsifying agent) 5%, Ketohexamethylene (cosolvent) 5%, dimethylbenzene (solvent) are supplemented to 100%.
Example of formulations 2,20% pyridine bacterium azoles pyrrole fluorine bacterium emulsifiable concentrate
Pyridine bacterium azoles 4%, pyrrole fluorine bacterium ester 16%, phenethyl phenol polyethenoxy ether (emulsifying agent) 5%, alkyl phenol formaldehyde resin polyoxyethylene ether (emulsifying agent) 2%, calcium dodecyl benzene sulfonate (emulsifying agent) 5%, isopropanol (cosolvent) 4.5%, dimethylbenzene (solvent) are supplemented to 100%.
Suspending agent embodiment
By each components such as active component, dispersant, wetting agent, defoamer, antifreezing agent, thickening agent, preservative and water in the ratio mix homogeneously of formula, after sand milling and high speed shear, obtain semi-finished product, add water mix homogeneously after analysis and filter and obtain suspending agent.
Example of formulations 3,30% pyridine bacterium azoles pyrrole fluorine bacterium ester suspending agent
Pyridine bacterium azoles 5%, pyrrole fluorine bacterium ester 25%, calcium lignosulfonate (dispersant) 3%, alkyl benzene calcium sulfonate (wetting agent) 2%, xanthan gum (thickening agent) 0.15%, ethylene glycol (antifreezing agent) 4%, 20% aqueous emulsion of dimethyl polysiloxane fluid (defoamer) 0.4%, sodium benzoate (preservative) 0.25%, water are supplemented to 100%.
Example of formulations 4,25.5% pyridine bacterium azoles pyrrole fluorine bacterium ester suspending agent
Pyridine bacterium azoles 0.5%, pyrrole fluorine bacterium ester 25%, calcium dodecyl benzene sulfonate (dispersant) 3.5%, pull open powder (wetting agent) 1%, xanthan gum (thickening agent) 0.2%, ethylene glycol (antifreezing agent) 4%, 20% aqueous emulsion of dimethyl polysiloxane fluid (defoamer) 0.4%, sodium benzoate (preservative) 0.2%, water are supplemented to 100%.
Example of formulations 5,20.5% pyridine bacterium azoles pyrrole fluorine bacterium ester suspending agent
Pyridine bacterium azoles 20%, pyrrole fluorine bacterium ester 0.5%, alkylphenol polyoxyethylene (dispersant) 3%, pull open powder (wetting agent) 1%, xanthan gum (thickening agent) 0.2%, ethylene glycol (antifreezing agent) 4%, 20% aqueous emulsion of dimethyl polysiloxane fluid (defoamer) 0.4%, sodium benzoate (preservative) 0.25%, water are supplemented to 100%.
Aqueous emulsion embodiment
In solvent, successively add pesticide activity component, emulsifying agent and defoamer in proportion, be sufficiently stirred for dissolving and make high concentration mother solution, add deionized water and stir, be subsequently adding antifreezing agent, after analytical control is qualified, prepare aqueous emulsion product.
Example of formulations 6,10% pyridine bacterium azoles pyrrole fluorine bacterium ester aqueous emulsion
Pyridine bacterium azoles 5%, pyrrole fluorine bacterium ester 5%, calcium dodecyl benzene sulfonate (emulsifying agent) 5%, phenethyl phenol polyethenoxy polyethenoxy ether (emulsifying agent) 3%, ethylene glycol (antifreezing agent) 4%, 20% aqueous emulsion of dimethyl polysiloxane fluid (defoamer) 0.4%, N-Methyl pyrrolidone (solvent) 15%, water are supplemented to 100%.
Example of formulations 7,5% pyridine bacterium azoles pyrrole fluorine bacterium ester aqueous emulsion
Pyridine bacterium azoles 2%, pyrrole fluorine bacterium ester 3%, calcium dodecyl benzene sulfonate (emulsifying agent) 5%, alkyl phenol formaldehyde resin polyoxyethylene ether (emulsifying agent) 3%, ethylene glycol (antifreezing agent) 4%, 20% aqueous emulsion of dimethyl polysiloxane fluid (defoamer) 0.4%, dimethylbenzene (solvent) 20%, water are supplemented to 100%.
Example of formulations 8,25.5% pyridine bacterium azoles pyrrole fluorine bacterium ester aqueous emulsion
Pyridine bacterium azoles 25%, pyrrole fluorine bacterium ester 0.5%, calcium dodecyl benzene sulfonate (emulsifying agent) 2%, phenethyl phenol polyethenoxy ether polyethenoxy ether (emulsifying agent) 4%, alkyl phenol formaldehyde resin polyoxyethylene ether (emulsifying agent) 4%, ethylene glycol (antifreezing agent) 4%, 20% aqueous emulsion of dimethyl polysiloxane fluid (defoamer) 0.4%, Ketohexamethylene (solvent) 20%, water are supplemented to 100%.
Microemulsion embodiment
Active component is dissolved in a small amount of solvent and cosolvent, adds emulsifying agent and water, under agitation mixed dissolution, make the microemulsion of homogeneous phase transparent.
Example of formulations 9,24% pyridine bacterium azoles pyrrole fluorine bacterium ester microemulsion
Pyridine bacterium azoles 20%, pyrrole fluorine bacterium ester 4%, phenethyl phenol polyethenoxy polyethenoxy ether (emulsifying agent) 10%, calcium dodecyl benzene sulfonate (emulsifying agent) 8%, N-Methyl pyrrolidone (cosolvent) 10%, isopropanol (cosolvent) 20%, water (solvent) are supplemented to 100%.
Example of formulations 10,15% pyridine bacterium azoles pyrrole fluorine bacterium ester microemulsion
Pyridine bacterium azoles 10%, pyrrole fluorine bacterium ester 5%, phenethyl phenol polyethenoxy polyethenoxy ether (emulsifying agent) 7%, alkyl phenol formaldehyde resin polyoxyethylene ether (emulsifying agent) 3%, calcium dodecyl benzene sulfonate (emulsifying agent) 6%, N-Methyl pyrrolidone (cosolvent) 10%, ethanol (cosolvent) 10%, water (solvent) are supplemented to 100%.
Water dispersible granules embodiment
By the mixing mixing of pesticide activity component, dispersant, wetting agent, diffusant, disintegrating agent and filler, through coarse pulverization and comminution by gas stream, then carry out mediating and extruder grain, dried screened prepared water dispersible granules product.
Example of formulations 11,85% pyridine bacterium azoles pyrrole fluorine bacterium ester water dispersible granules
Pyridine bacterium azoles 25%, pyrrole fluorine bacterium ester 60%, sodium lauryl sulphate (wetting agent) 3%, calcium lignosulfonate (dispersant) 5%, naphthalene sulfonate (diffusant) 4%, Kaolin (filler) complement to 100%.
Example of formulations 12,20.5% pyridine bacterium azoles pyrrole fluorine bacterium ester water dispersible granules
Pyridine bacterium azoles 0.5%, pyrrole fluorine bacterium ester 20%, Laurel alcohol radical sodium sulfate (wetting agent) 2%, calcium lignosulfonate (dispersant) 6%, naphthalene sulfonate (diffusant) 6%, carbamide (disintegrating agent) 8%, convex-concave rod stone (filler) complement to 100%.
Example of formulations 13,44% pyridine bacterium azoles pyrrole fluorine bacterium ester water dispersible granules
Pyridine bacterium azoles 40%, pyrrole fluorine bacterium ester 4%, Fructus Sapindi Mukouossi powder (wetting agent) 3%, calcium lignosulfonate (dispersant) 12%, poly-naphthalene formaldehyde sulfonate salt (diffusant) 6%, bentonite (disintegrating agent) 10%, Kaolin (filler) complement to 100%.
Example of formulations 14,62% pyridine bacterium azoles pyrrole fluorine bacterium ester water dispersible granules
Pyridine bacterium azoles 2%, pyrrole fluorine bacterium ester 60%, sodium lauryl sulphate (wetting agent) 4%, calcium lignosulfonate (dispersant) 10%, naphthalene sulfonate (diffusant) 6%, ammonium sulfate (disintegrating agent) 6%, Kaolin (filler) complement to 100%.
Wettable powder embodiment
Pesticide activity component, wetting agent, dispersant, diffusant and filler etc. are mixed in proportion successively, after comminution by gas stream, remix prepared wettable powder product.
Example of formulations 15,22% pyridine bacterium azoles pyrrole fluorine bacterium ester wettable powder
Pyridine bacterium azoles 2%, pyrrole fluorine bacterium ester 20%, Laurel alcohol radical sodium sulfate (wetting agent) 3%, calcium lignosulfonate (dispersant) 6%, naphthalene sulfonate (diffusant) 3%, white carbon (filler) 8%, bentonite (filler) complement to 100%.
Example of formulations 16,15.5% pyridine bacterium azoles pyrrole fluorine bacterium ester wettable powder
Pyridine bacterium azoles 15%, pyrrole fluorine bacterium ester 0.5%, sodium lauryl sulphate (wetting agent) 2%, calcium lignosulfonate (dispersant) 6%, naphthalene sulfonate (diffusant) 4%, precipitated calcium carbonate (filler) 6%, convex-concave rod stone (filler) complement to 100%.
Example of formulations 17,42% pyridine bacterium azoles pyrrole fluorine bacterium ester wettable powder
Pyridine bacterium azoles 2%, pyrrole fluorine bacterium ester 40%, sodium lauryl sulphate (wetting agent) 3%, calcium lignosulfonate (dispersant) 8%, naphthalene sulfonate (diffusant) 4%, bentonite (filler) 8%, Kaolin (filler) complement to 100%.
Field information example 1: pyridine bacterium azoles and the pyrrole composite field control effectiveness test to powdery mildew of cucumber of fluorine bacterium ester
Testing and carry out in Dinghu District, Zhaoqing City of Guangdong Province in the 6-7 month in 2014, experimental field powdery mildew of cucumber over the years occurs serious.Test medicine and dosage refer to table 2, often process 4 times and repeat, plot area 20m2, Gong44Ge community, random district group arranges.Adopting conventional nebulization, medicinal liquid consumption is 750L/hm2, uniformly spray Herb, with squirt blade do not drip for degree.Carry out first time dispenser at powdery mildew of cucumber their early stage, after 7 days, carry out second time dispenser, separately set clear water and process as blank.Before dispenser investigate state of an illness radix, second time dispenser before and second time dispenser after 14 days investigation prevention effects.Every community takes 4 points at random, every some investigation 2 strains, and whole blades are investigated in every strain, records total number of sheets, the sick number of sheets, records the sick number of sheets at different levels, calculates disease index and preventive effect.
Table 2 pyridine bacterium azoles and the composite field control effectiveness test result to powdery mildew of cucumber of pyrrole fluorine bacterium ester
From table 2, result of the test can be seen that, powdery mildew of cucumber is had good prevention effect by the embodiment of the present invention, preventive effect before second time dispenser is 68.18%～78.20%, after second time dispenser, the preventive effect of 14 days is 83.02%～89.37%, hence it is evident that be better than the preventive effect 67.32%, 60.70% and 75.31%, 67.79% of comparison medicament 25% pyridine bacterium azoles cream and 15% pyrrole fluorine bacterium ester suspending agent.Under corresponding test dose, reagent agent can effectively control the occurrence injury of powdery mildew of cucumber, and the lasting period is longer, homochronous gray mold of cucumber is had and double controls effect.During test, reagent agent, to trial crops safety, occurs without poisoning, to beneficial organism safety such as Apis and natural enemy trichogrammas.
Field information embodiment 2: pyridine bacterium azoles and the pyrrole composite field control effectiveness test to uncinula necator of fluorine bacterium ester
Testing and carry out in Yangling District Li Tai township of Xianyang, Shanxi province city in July, 2014, uncinula necator over the years occurs serious.Test medicine and dosage refer to table 3, often process 4 times and repeat, plot area 20m2, Gong44Ge community, random district group arranges.Adopting conventional nebulization, medicinal liquid consumption is 1800L/hm2, uniformly spray Herb, with squirt blade do not drip for degree.Carry out first time dispenser at uncinula necator their early stage, after 20 days, carry out second time dispenser, separately set clear water and process as blank.Before dispenser investigate state of an illness radix, second time dispenser before and second time dispenser after 14 days investigation prevention effects.
Table 3 pyridine bacterium azoles and the composite field control effectiveness test result to uncinula necator of pyrrole fluorine bacterium ester
From table 3, result of the test can be seen that, uncinula necator is had good prevention effect by the embodiment of the present invention, preventive effect before second time dispenser is 74.22%～83.63%, after second time dispenser, the preventive effect of 14 days is 85.50%～92.03%, hence it is evident that be better than the preventive effect 66.91%, 60.21% and 75.40%, 68.65% of comparison medicament 25% pyridine bacterium azoles cream and 15% pyrrole fluorine bacterium ester suspending agent.Under corresponding test dose, reagent agent can effectively control the occurrence injury of uncinula necator, and the lasting period is longer, homochronous grape grey mould is had and double controls effect.During test, reagent agent, to trial crops safety, occurs without poisoning, to beneficial organism safety such as Apis and natural enemy trichogrammas.
Field information embodiment 3: pyridine bacterium azoles and the pyrrole composite field control effectiveness test to powdery mildew of strawberry of fluorine bacterium ester
Testing and carry out in Shilou County town, Fanyu District, Guangzhou, Guangdong in February, 2015, experimental field powdery mildew of strawberry over the years occurs serious.Test medicine and dosage refer to table 4, often process 4 times and repeat, plot area 25m2, Gong44Ge community, random district group arranges.Adopting conventional nebulization, medicinal liquid consumption is 750L/hm2, uniformly spray Herb, with squirt blade do not drip for degree.Carry out first time dispenser at powdery mildew of strawberry their early stage, after 7 days, carry out second time dispenser, separately set clear water and process as blank.Before dispenser investigate state of an illness radix, second time dispenser before and second time dispenser after 10 days investigation prevention effects.Every community adopts diagonal 5 sampling, every some investigation 3 strains, and whole blades are investigated in every strain, records total number of sheets, the sick number of sheets, records the sick number of sheets at different levels, calculates disease index and preventive effect.
Table 4 pyridine bacterium azoles and the composite field control effectiveness test result to powdery mildew of strawberry of pyrrole fluorine bacterium ester
From table 4, result of the test can be seen that, powdery mildew of strawberry is had good prevention effect by the embodiment of the present invention, preventive effect before second time dispenser is 74.89%～81.03%, after second time dispenser, the preventive effect of 10 days is 86.05%～90.57%, hence it is evident that be better than the preventive effect 68.07%, 62.20% and 76.32%, 69.34% of comparison medicament 25% pyridine bacterium azoles cream and 15% pyrrole fluorine bacterium ester suspending agent.Under corresponding test dose, reagent agent can effectively control the occurrence injury of Fructus Fragariae Ananssae white lead, and the lasting period is longer, homochronous grey mould fruit rot of strawberry is had and double controls effect.During test, reagent agent, to trial crops safety, occurs without poisoning, to beneficial organism safety such as Apis and natural enemy trichogrammas.
Field information embodiment 4: pyridine bacterium azoles and the pyrrole composite field control effectiveness test to wheat powdery mildew of fluorine bacterium ester
Test in 4～May in 2014 Gao Xiang on Taishan District of Taian City, Shandong Province carry out, experimental field wheat powdery mildew over the years occurs serious.Test medicine and dosage refer to table 5, often process 4 times and repeat, plot area 20m2, Gong44Ge community, random district group arranges.Adopting conventional nebulization, medicinal liquid consumption is 750L/hm2, uniformly spray Herb, with squirt blade do not drip for degree.Carry out first time dispenser at wheat powdery mildew their early stage, after 7 days, carry out second time dispenser, separately set clear water and process as blank.Before dispenser investigate state of an illness radix, second time dispenser before and second time dispenser after 14 days investigation prevention effects.
Table 5 pyridine bacterium azoles and the composite field control effectiveness test result to wheat powdery mildew of pyrrole fluorine bacterium ester
From table 5, result of the test can be seen that, wheat powdery mildew is had good prevention effect by the embodiment of the present invention, preventive effect before second time dispenser is 69.87%～82.74%, after second time dispenser, the preventive effect of 14 days is 85.65%～91.77%, hence it is evident that be better than the preventive effect 68.42%, 60.14% and 76.40%, 67.57% of comparison medicament 25% pyridine bacterium azole suspending agent and 15% pyrrole fluorine bacterium ester suspending agent.Under corresponding test dose, reagent agent can effectively control the occurrence injury of wheat powdery mildew, and the lasting period is longer, homochronous wheat sharp eyespot is had and double controls effect.During test, reagent agent, to trial crops safety, occurs without poisoning, to beneficial organism safety such as Apis and natural enemy trichogrammas.
Claims (6)
1. the bactericidal composition containing pyridine bacterium azoles, it is characterised in that: the effective ingredient of described bactericidal composition is pyridine bacterium azoles and pyrrole fluorine bacterium ester, and both mass ratioes are 1:50～50:1.
2. bactericidal composition according to claim 1, it is characterised in that: the mass ratio of effective ingredient pyridine bacterium azoles and pyrrole fluorine bacterium ester is 1:20～20:1.
3. bactericidal composition according to claim 2, it is characterised in that: the mass ratio of effective ingredient pyridine bacterium azoles and pyrrole fluorine bacterium ester is 1:10～10:1.
4. the bactericidal composition according to any one of claims 1 to 3, it is characterised in that: in bactericidal composition, the gross mass percentage composition of effective ingredient is 5%～85%.
5. bactericidal composition according to claim 4, it is characterised in that: the dosage form of described bactericidal composition is cream, suspending agent, aqueous emulsion, microemulsion, water dispersible granules or wettable powder.
6. bactericidal composition described in claim 1 is for preventing and treating the purposes of vegetable, fruit tree, cereal crop powdery mildew.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280767A (en) * | 1999-07-14 | 2001-01-24 | 沈阳化工研究院 | Heterocycle substituted isoxazoline compounds used as disinfectant |
| CN1608467A (en) * | 2003-10-24 | 2005-04-27 | 沈阳化工研究院 | Bactericide composition containing SYP-Zo48 |
| CN1907024A (en) * | 2005-08-03 | 2007-02-07 | 浙江化工科技集团有限公司 | Methoxyl group displacement methyl acrylate compound bactericidal agent |
| CN102239850A (en) * | 2011-04-26 | 2011-11-16 | 中化蓝天集团有限公司 | Fluopicolpkd-containing agricultural bactericidal composition |
| CN103355332A (en) * | 2013-06-29 | 2013-10-23 | 海利尔药业集团股份有限公司 | Sterilization composition containing SYP-Z048 and pyraclostrobin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280767A (en) * | 1999-07-14 | 2001-01-24 | 沈阳化工研究院 | Heterocycle substituted isoxazoline compounds used as disinfectant |
| CN1608467A (en) * | 2003-10-24 | 2005-04-27 | 沈阳化工研究院 | Bactericide composition containing SYP-Zo48 |
| CN1907024A (en) * | 2005-08-03 | 2007-02-07 | 浙江化工科技集团有限公司 | Methoxyl group displacement methyl acrylate compound bactericidal agent |
| CN102239850A (en) * | 2011-04-26 | 2011-11-16 | 中化蓝天集团有限公司 | Fluopicolpkd-containing agricultural bactericidal composition |
| CN103355332A (en) * | 2013-06-29 | 2013-10-23 | 海利尔药业集团股份有限公司 | Sterilization composition containing SYP-Z048 and pyraclostrobin |
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