CN109479886A - A kind of pesticide and preparation method containing prothioconazoles and probenazole - Google Patents
A kind of pesticide and preparation method containing prothioconazoles and probenazole Download PDFInfo
- Publication number
- CN109479886A CN109479886A CN201811361636.3A CN201811361636A CN109479886A CN 109479886 A CN109479886 A CN 109479886A CN 201811361636 A CN201811361636 A CN 201811361636A CN 109479886 A CN109479886 A CN 109479886A
- Authority
- CN
- China
- Prior art keywords
- probenazole
- prothioconazoles
- pesticide
- parts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000000575 pesticide Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 239000004615 ingredient Substances 0.000 claims abstract description 7
- 239000000375 suspending agent Substances 0.000 claims abstract description 7
- 238000004945 emulsification Methods 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 241000219109 Citrullus Species 0.000 claims description 21
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 241000894006 Bacteria Species 0.000 claims description 10
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 4
- 150000003851 azoles Chemical class 0.000 claims description 3
- 229930192474 thiophene Natural products 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 206010059866 Drug resistance Diseases 0.000 abstract description 3
- 230000002411 adverse Effects 0.000 abstract description 3
- 230000010534 mechanism of action Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 9
- 241000196324 Embryophyta Species 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000002270 dispersing agent Substances 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- -1 alkyl naphthalene formaldehyde Chemical compound 0.000 description 3
- 239000002518 antifoaming agent Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 239000000417 fungicide Substances 0.000 description 3
- 229920005646 polycarboxylate Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 244000241257 Cucumis melo Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 230000017858 demethylation Effects 0.000 description 2
- 238000010520 demethylation reaction Methods 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 2
- 230000000361 pesticidal effect Effects 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical group CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 241001272567 Hominoidea Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- RRTCFFFUTAGOSG-UHFFFAOYSA-N benzene;phenol Chemical compound C1=CC=CC=C1.OC1=CC=CC=C1 RRTCFFFUTAGOSG-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000009335 monocropping Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to pesticide sterilizing technical fields, in particular disclose a kind of pesticide and preparation method containing prothioconazoles and probenazole, raw material including following parts by weight: effective ingredient is prothioconazoles 1-30 parts, 1-30 parts of probenazole, include the following steps, prothioconazoles and probenazole are mixed in proportion, the suspending agent of prothioconazoles and probenazole is made after high speed shear, emulsification.The present invention shows apparent synergistic effect within a certain ratio range, the control efficiency of composition is significantly improved than single dose, reduce the dosage of pesticide, reduce the number of medication, the cost for reducing medication reduces pesticide to some adverse effects of ecological environment, and two kinds of effective ingredient mechanism of action are different, it is conducive to overcome and delay the generation of germ drug resistance, extends the service life of medicament.
Description
Technical field
The present invention relates to pesticide sterilizing technical field more particularly to a kind of pesticides and system containing prothioconazoles and probenazole
Preparation Method.
Background technique
Watermelon blight is to belong to soil-borne disease caused by watermelon point sickle armful bacterium is infected by Deuteromycotina fungi, is known as and " plants
The title of object cancer " can occur in each period of watermelon growing, do not only result in watermelon offspring and ground stem above section is withered dead
Die, the underproduction of being short of seedling, and germ can also contaminated soil, infecting potential plants watermelon from continuous cropping, especially in soil up to 4-7
Earth water content is high, falls ill when humidity is big serious.
Prothioconazoles are a kind of Fungicide: Prothio-conazoles, are a kind of demethylation inhibitors (DMI), play inhibition
Precursor-lanosterol of sterol demethylation on 14- or -24 methylene lanostenols acts in fungi.
Pass through a large amount of field control effectiveness test, the results showed that prothioconazoles not only have crops good safety
Property, controlling disease effect is very good, and volume increase is more obvious, and compared with triazole bactericidal agent, prothioconazoles have wide spectrum
Bactericidal activity, and validity period is long.
Probenazole is heterocyclic systemic fungicide, while being a kind of soil sterilants again, is had to samping off preferable pre-
Anti- effect.Caused by this samping off is usually rotten mildew, sickle-like bacteria etc..The medicine in soil iron, in conjunction with aluminium ion, inhibit
The rudiment of spore.Probenazole can be absorbed by the root of plant and be moved in root system, two kinds of glucosides be generated in plant intracellular metabolite, to work
Object is improved the effect of physiological activity, and so as to promote plant strain growth, the activity for dividing evil, the increase of root hair and root of root is improved.
Prothioconazoles and probenazole mixture and application, there is no report at present.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the one kind proposed contains prothioconazoles and thiophene
The pesticide and preparation method of bacterium spirit.
To achieve the goals above, present invention employs following technical solutions:
The present invention is tested by a large amount of field medicine effect test and indoor bioassay, find prothioconazoles and probenazole with
After certain ratio mixture, there is significant synergistic effect to wilt disease.
On the basis of above-mentioned discovery, after further study, technical solution of the present invention is formd, it may be assumed that one kind contains rosickyite
The pesticide of bacterium azoles and probenazole, the raw material including following parts by weight:: effective ingredient is prothioconazoles 1-30 parts, probenazole 1-30
Part, the weight part ratio of prothioconazoles and probenazole is the weight summation of 1-30:1-30 prothioconazoles and probenazole in pesticide
Weight percent in composition is 1%-50%.
A kind of preparation method of the pesticide containing prothioconazoles and probenazole, includes the following steps, by prothioconazoles and thiophene bacterium
Spirit mixes in proportion, and the suspending agent of prothioconazoles and probenazole is made after high speed shear, emulsification.
Composition pesticide of the invention can be processed into suspending agent, wettable according to methods well known to those skilled in the art
The application forms of the suitable agricultural use such as agent.
Composition pesticide of the invention also contain prepare pesticidal preparations needed for auxiliary element, including emulsifier, stabilizer,
One or more of wetting agent, dispersing agent, thickener, antifreezing agent, defoaming agent, filler, filler, medium etc. mix, and are
Known substance is common various auxiliary agents in pesticidal preparations, can be varied, be not particularly limited according to different situations.
For suspending agent, the emulsifier used can be naphthalene or alkyl naphthalene formaldehyde condensation product and its salt, Nongru-700#It is (general
Name alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 1601#(common name triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block
Polymer), sorbierite is one or more of with monostearate.The dispersing agent used can be lignin and its derivative sulphur
One or more of hydrochlorate, pull open powder, polycarboxylate, alkylnaphthalene sulfonate.The wetting agent used can be alkylsulfonate,
Naphthalene sulfonate, alkyl sulfate, tea seed cake powder, spaonin powder, APES formaldehyde condensation product phosphate, phenethyl phenol are poly-
One or more of oxyethylene group ether phosphoric acid rouge.Thickener can be methylcellulose, bentonite, aluminum magnesium silicate, polyethylene
One or more of alcohol, xanthan gum；Preservative can be one or more of sodium benzoate, formaldehyde, benzoic acid；Defoaming agent
It is organosilicon；Antifreezing agent can be one or more of glycerol, ethylene glycol, urea, propylene glycol, sodium chloride.
For wettable powder, dispersing agent just just be lignin and its derivative sulfonate, alkylnaphthalene sulfonate,
One or more of polycarboxylate, naphthalenesulfonate formaldehyde condensation compound.Wetting agent can be alkyl sulfate, naphthalene sulfonate, alkane
One or more of base sulfonate, nonylphenol polyoxyethylene ether.Filler for example kaolin, calcium bicarbonate, talcum powder, white carbon black,
One or more of diatomite, clay.
Composition pesticide described in the invention can be provided in the form of finished product preparation, i.e., each substance has mixed in composition
It closes, the ingredient of composition can also be provided with unit dose form, directly be mixed in cans or buckets using preceding, dense needed for being then diluted to
Degree.
Composition pesticide described in the invention, for preventing and treating watermelon blight.
Composition pesticide described in the invention can be used using pouring root, method that is spraying, spreading fertilizer over the fields, can also basis
It needs using used in agriculture other using technology.
Composition pesticide described in the invention has the beneficial effect that.
1, composition pesticide provided by the invention shows apparent synergistic effect, composition within a certain ratio range
Control efficiency be significantly improved than single dose, reduce the dosage of pesticide, reduce the number of medication, reduce use
The cost of medicine reduces pesticide to some adverse effects of ecological environment.
2, composition pesticide provided by the invention, two kinds of effective ingredient mechanism of action are different, are conducive to overcome and prolong
The generation of slow germ drug resistance, extends the service life of medicament.
3, composition pesticide provided by the invention, drug effect play rapidly, and the lasting period is long, and use cost decreases, and use
More convenient, time saving and energy saving, popularization and application have huge economic benefit and social benefit.
4, composition pesticide provided by the invention, dosage form environmental protection are very safe to crops.
Specific embodiment
In order to keep the objectives, technical solutions, and advantages of the present invention more concise, present invention following specific embodiments
It is illustrated, but the present invention is by no means limited to these examples.The following is only the preferred embodiment of the present invention, is used only for retouching
The present invention is stated, should not be understood as limiting the scope of the present invention.It should be pointed out that it is all the spirit and principles in the present invention it
Interior done any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention.Therefore, of the invention
The scope of protection shall be subject to the appended claims for patent.
In these embodiments, unless otherwise stated, all percentages are weight percentage.
Different types of pesticide active ingredient is subjected to mixture, is use cost in current solution pesticide single dose application process
And a kind of effective means of the problems such as drug resistance.After different types of pesticide active ingredient mixture, three kinds of effects are typically exhibited
Type, i.e. synergistic effect, summation action, antagonism.The present invention is on the basis of a large amount of indoor and outdoors biometrics are tested, hair
Existing prothioconazoles and probenazole have significant synergies to wilt within the scope of certain mixed ratio.
Assays Example 1: prothioconazoles are with probenazole mixture to the indoor toxicity test of withered germ of water-melon.
Material selection: the watermelon blight disease grass in field is picked up from.
Test method: first using 98% prothioconazoles raw medicine of acetone solution and 94% probenazole raw medicine, and single dose mother is respectively prepared
Liquid.According to preliminary experiment as a result, on the basis of above-mentioned single dose mother liquor, appropriate two raw medicines are configured to five kinds of different ratios
Mixture, then with the dilution of the aqueous solution of the Tween 80 containing 0.1% to be configured to 6 series mass strength solutions respectively stand-by.Rosickyite
Bacterium azoles is diluted to 80 μ g/ml, 40 μ g/ml, 20 μ g/ml, 10 μ g/ml, 5 μ g/ml, l μ g/ml；Probenazole is diluted to 160 μ g/ml,
80μg/ml,40μg/ml,20μg/ml,10μg/ml,5μg/ml；Prothioconazoles and five kinds of different ratio (effective ingredients of probenazole
Weight ratio is 30:1,15:1,1:1,1:15,1:30) it is diluted to 64 μ g/ml, 32 μ g/ml, 16 μ g/ml, 8 μ g/ml, 4 μ g/
ml。
Selection grows consistent two melon seedling, and each processing is selected 5 basins for trying watermelon melon seedling, ridden over by spraying with Pottor
It is spraying under pressure under 50PSI, every basin about 20ml.Bacterium is connect after chemicals treatment for 24 hours, the watermelon blight disease leaf for picking up from field is existed
Uniformly shake off conidium on watermelon seedling to be inoculated with, then watermelon seedling is put into greenhouse and is cultivated, it is withered according to watermelon after 7d
The morbidity grouping standard complete stool of disease investigates disease index.
According to survey data, each concentration for the treatment of is calculated to the mycelia growth suppression for trying target bacterium by NY/T1156.2-2006
Rate processed, unit are percentage (%).
Using the logarithm of drug concentration (μ g/m1) as independent variable x, using the probit value of inhibiting rate as dependent variable Y, establish respectively
Virulence regression equation calculates the EC of single dose and each proportion mixture using DPS software50The total poison system of (95% confidence limit) and mixture
Number (CTC).
According to the NY/T1156.6-2006 fungicide synergy criteria for classifying: co-toxicity coefficient (CTC) } 120 show as synergy
Effect；Co-toxicity coefficient (CTC } } 80 show as antagonism；80 < co-toxicity coefficient (CTC } < 120 show as summation action.
The toxicity test result of table 1, prothioconazoles and probenazole and different ratio to withered germ of water-melon.
From test result table 1 as can be seen that prothioconazoles and probenazole mixture weight amount portion rate be 30:1-1:30 it
Between, co-toxicity coefficient (CTC value) is all larger than 120, i.e., shows apparent synergistic effect.Prothioconazoles and probenazole mixture have
Reasonability and feasibility are worth further crop field to promote and apply.
It is further illustrated below with example of formulations.
Example of formulations 1:20% prothioconazoles probenazole suspending agent.
Prothioconazoles 4%, probenazole 16%, polycarboxylate 4% (dispersing agent), lauryl sodium sulfate 2% (wetting agent),
Nongru-700#5% (emulsifier), organosilicon 0.5% (defoaming agent), xanthan gum 2% (thickener), urea 1% (antifreeze) are gone
Ionized water complements to 100% (filler).
After above-mentioned raw materials are mixed in proportion, it is outstanding that 20% prothioconazoles probenazole is made after high speed shear, emulsification
Floating agent.
Example of formulations 2:50% prothioconazoles probenazole wettable powder.
Prothioconazoles 5%, probenazole 45%, NN012% (dispersing agent), pull open powder 3% (wetting agent), talcum powder 4% (point
Powder), kaolin complements to 100% (filler).
It is uniformly mixed entering in mixer after above-mentioned formula in proportion coarse crushing, obtains 50% after the airflow crushes
Prothioconazoles probenazole wettable powder.
Field efficacy embodiment 1: prothioconazoles are with probenazole mixture to the field control effectiveness test of watermelon blight.
Test site is in Huidong County, Guangdong Huizhou city town Wen Shan Laokeng Village.Test medicine and dosage are shown in Table 2, every processing 4
A cell repeats, 20 square metres of each plot area.First time application is carried out in watermelon blight early stage, is watered uniform spray
Mist, using clear water processing as blank control.It carries out being administered for second after 7 days.It investigates within 7 days before first time medicine and after second of medicine
The incidence of watermelon blight.Every cell is using 5 points of samplings, and every is investigated two plants, every plant of all blades of investigation, with scab
Area accounts for the percentage of entire blade area to be classified record.Calculate each processing disease index and control efficiency.
Grade scale:
0 grade: disease-free spot.
1 grade: lesion area accounts for 5% or less entire leaf area.
3 grades: lesion area accounts for the 6%-15% of entire leaf area.
5 grades: lesion area accounts for the 16%-25% of entire leaf area.
7 grades: lesion area accounts for the 26%-50% of entire leaf area.
9 grades: lesion area accounts for 50% or more of entire leaf area.
According to survey data, the disease index and control efficiency of each processing are calculated.
Calculation formula are as follows:
In above-mentioned formula: Ni: the disease numbers of sheets at different levels；i；Opposite value of series；N: investigation total number of sheets.
From test result table 2 it can be seen that prothioconazoles, probenazole single dose are respectively to the preventive effect of watermelon blight
75.2%, 68.5%.Prothioconazoles and probenazole composition pesticide preventive effect of the invention are apparently higher than single dose, and test result is abundant
There is apparent synergistic effect to watermelon blight after showing prothioconazoles and probenazole mixture, drug effect can be improved, reduce agriculture
The dosage of medicine reduces times for spraying, reduces drug cost, reduces pesticide to the adverse effect of ecological environment, is worth into one
Step is promoted the use of.
The field control effectiveness test result of table 2, prothioconazoles and probenazole mixture to watermelon blight.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of pesticide containing prothioconazoles and probenazole, which is characterized in that the raw material including following parts by weight:: effective ingredient
For 1-30 parts of prothioconazoles, 1-30 parts of probenazole.
2. a kind of pesticide containing prothioconazoles and probenazole according to claim 1, which is characterized in that the prothioconazoles
Weight part ratio with probenazole is 1-30:1-30.
3. a kind of pesticide containing prothioconazoles and probenazole according to claim 1, which is characterized in that prothioconazoles and thiophene
Weight percent of the weight summation of bacterium spirit in composition pesticide is 1%-50%.
4. a kind of pesticide containing prothioconazoles and probenazole according to claim 1, which is characterized in that the pesticide processing
At suspending agent or wettable powder.
5. a kind of pesticide containing prothioconazoles and probenazole according to claim 1, which is characterized in that for preventing and treating watermelon
Wilt disease.
6. a kind of preparation method of the pesticide containing prothioconazoles and probenazole, which is characterized in that include the following steps, by rosickyite bacterium
Azoles and probenazole mix in proportion, and the suspending agent of prothioconazoles and probenazole is made after high speed shear, emulsification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811361636.3A CN109479886A (en) | 2018-11-15 | 2018-11-15 | A kind of pesticide and preparation method containing prothioconazoles and probenazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811361636.3A CN109479886A (en) | 2018-11-15 | 2018-11-15 | A kind of pesticide and preparation method containing prothioconazoles and probenazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109479886A true CN109479886A (en) | 2019-03-19 |
Family
ID=65694993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811361636.3A Pending CN109479886A (en) | 2018-11-15 | 2018-11-15 | A kind of pesticide and preparation method containing prothioconazoles and probenazole |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109479886A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023118818A1 (en) * | 2021-12-21 | 2023-06-29 | UPL Corporation Limited | Fungicidal combinations |
-
2018
- 2018-11-15 CN CN201811361636.3A patent/CN109479886A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023118818A1 (en) * | 2021-12-21 | 2023-06-29 | UPL Corporation Limited | Fungicidal combinations |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101548677B (en) | Sterilizing compound of ethirimol and triazole | |
| CN102669114B (en) | A kind of prothioconazoles that contains is with the composition pesticide of hymexazo | |
| CN103858886A (en) | Sterilizing composition containing isopyrazam | |
| CN109938045A (en) | Composition pesticide containing toVerticilliumdahliaActivitie Activitie S of Relative activator protein and Physcion | |
| CN105265443A (en) | Bactericidal composition containing fluxapyroxad | |
| CN109479886A (en) | A kind of pesticide and preparation method containing prothioconazoles and probenazole | |
| CN107660546A (en) | A kind of bactericidal composition containing thifluzamide and amino-oligosaccharide | |
| CN101697722B (en) | Famoxadone-containing bactericidal composition | |
| CN108849918A (en) | Bactericidal composition | |
| CN109845736A (en) | Bactericidal composition containing toVerticilliumdahliaActivitie Activitie S of Relative activator protein and Physcion | |
| CN102007929B (en) | Thifluzamide-containing bactericidal composition | |
| CN108605961A (en) | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and its application | |
| CN109169675A (en) | A kind of bactericidal composition of Fluxapyroxad-containsterilization and copper 8-hydroxyquinolinate | |
| CN104798796B (en) | A kind of bactericidal composition containing benzo alkene fluorine bacterium azoles and application thereof | |
| CN106665594A (en) | Sterilization composition containing flutianil | |
| CN105340898A (en) | Sterilization composition containing penthiopyrad and fludioxonil | |
| CN104982439A (en) | Pesticide combination for preventing and controlling crop powdery mildew | |
| CN102342287A (en) | Sterilization composition containing fluopicolide and polyoxin | |
| CN108419802A (en) | Bactericidal composition | |
| CN102388893B (en) | Pesticide composition containing ZJ0712 and tetraconazole | |
| CN108419805A (en) | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol | |
| CN108576008A (en) | Bactericidal composition and its application | |
| CN108157375A (en) | A kind of bactericidal composition containing flutianil and its application | |
| CN106614629A (en) | Sterilization composition including flutianil | |
| CN106665595A (en) | Bactericidal composition containing flutianil and application of bactericidal composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190319 |
|
| WD01 | Invention patent application deemed withdrawn after publication |