CN1048157A - A kind of preparation technology of medical pelletron - Google Patents
A kind of preparation technology of medical pelletron Download PDFInfo
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- CN1048157A CN1048157A CN 89104306 CN89104306A CN1048157A CN 1048157 A CN1048157 A CN 1048157A CN 89104306 CN89104306 CN 89104306 CN 89104306 A CN89104306 A CN 89104306A CN 1048157 A CN1048157 A CN 1048157A
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- pelletron
- infection
- polymethyl methacrylate
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Abstract
A kind of preparation technology of medical pelletron.The preparation method that belongs to the topical drug of bone, surgery use.Adopt the Chinese medicine berberine powder as the active drug composition, with polymethyl methacrylate polymer and monomer whose as solidification matrix.And the shape of pearl in the pelletron is processed into sphere, ellipse or with holes according to the wound surface needs.Thereby, pelletron with prepared of the present invention proves the prevention infection that is applicable to chronic osteomyelitis, traumatic infection, deep soft tissue's infection, fistula, sinus tract and compound fracture through using, biological activity is stable, human body is had no side effect and anaphylaxis, be convenient to transfer to and can make slow release or localized mass is released type according to the state of an illness.
Description
A kind of preparation technology of medical pelletron, the preparation technology of the topical drug that genus bone, surgery use.
At present, at bone, surgery clinically, be used for chronic osteomyelitis, trauma infection contamination, abscess and cut fistula, sinus tract behind the row, the pelletron of cases such as compound fracture prevention infection treatment is made as raw material by antibiotics, polymethyl methacrylate polymer and polymethyl methacrylate monomer.For example, celebrate big pelletron, use gentamycin, polymethyl methacrylate polymer and monomer as raw material.
Pour a fixed mold after the stirring into,, make a string pelletron that strings spherical pearl by stainless steel silk through solidifying.They are placed to focal zone, the antibiotics in the pelletron then, for example: gentamycin, obtain discharging, form high local concentrations killing perilesional antibacterial, and can play drainage.But in the technology of existing preparation pelletron, the antibiotics of used active drug composition all is Western medicine, all has certain poison to pay effect, and for example: gentamycin has infringement to liver, kidney and the 8th pair of cranial nerve, and human body is easily irritated, biologically active labile.And the cost of material height with existing prepared causes pelletron to cost an arm and a leg, for example: celebrate about 11 yuan/every string of big pelletron.
The present invention seeks to develop nontoxic pair of effect of a kind of preparation, do not have irritated reaction, the cheap new technology that is suitable for the spacetabs type pelletron of clinical practice.
In order to realize the foregoing invention purpose, the present invention adopts berberine powder as the active drug composition, with polymethyl methacrylate polymer and monomer whose as solidification matrix.Because berberine be a kind of known, through clinical practice proof staphylococcus aureus, Hemolytic streptococcus, colibacillus, green dense liver bacterium etc. are all had the Chinese medicine of sterilization and bacteriostasis, biological activity is stable, to nontoxic pair of reaction of human body, does not have irritated reaction.Concrete preparation is that berberine powder is mixed with polymethyl methacrylate polymer and polymethyl methacrylate monomer, transfer to dough period not, pour into by pelletron shape need design, giving of preparing and be embedded with in the mould wiry that human body is not reacted, solidify, the demoulding forms.In addition, have finite concentration in order to guarantee the Rhizoma Coptidis in the pelletron, simultaneously berberine powder can be combined with solidification matrix is good, during preparation, the proportioning of berberine powder and polymethyl methacrylate polymer is 0.5: 2-5: the 1(weight ratio)
For the multiple special shape wound surface of suitable administration's human body, so that extract after operation, the shape of each pearl can be processed by spherical or ellipse garden shape in the pelletron.
In order to adapt to the different needs of wound, can carry out different boring processing on each pearl in pelletron, can bore one or more hole, Kong Yue is many, and the medicine star of Shi Fanging is many more at short notice.
Be described further below in conjunction with embodiment and accompanying drawing thereof:
Embodiment 1: at first, by requirement shown in Figure 1 design and give molding jig, mould is that two halves close up, 21 in the hole that pearl 2 matches in total shape and the pelletron, and in mould, lay 1 one of the stainless steel silks that diameter is 0.6mm.
Again refining berberine powder 5g of 100 purposes and polymethyl methacrylate polymer 10g mix homogeneously, measure polymethyl methacrylate monomer 10ml, add in the above-mentioned blended powder, the limit edged is transferred, be stirred to and be dough period not, pour in the die cavity of the above-mentioned mould for preparing, two halves close up again, and pressurize outside mould, mixture demoulding after solidifying 4～6 hours in the die cavity, remove unnecessary burr, illustration 2 in kind according to shown in a string pelletron, have the spherical pearl that 21 diameters are 7mm.
Embodiment 2: the medicine, chemical compound and the preparation method that contain in Mould design preparation process and the pelletron are all identical with embodiment 1, and different is:
1. the match ratio of berberine powder and polymethyl methacrylate polymer is 0.5: 2.
2. the hole in the die cavity is an ellipse garden shape.Make the pearl 2 of the pelletron of making be ellipse garden shape shown in Figure 3, its major axis 7mm, minor axis are 5mm, totally 26.
Embodiment 3: the medicine, chemical compound and the preparation method that contain in Mould design preparation process and the pelletron are all identical with embodiment 1, and the pearl shape is identical with embodiment 1 or 2, and different is:
1. be drilled with several holes 3 at the short-axis direction of pearl 2 as shown in Figure 4.
2. the match ratio of berberine powder and polymethyl methyl ester is 5: 1.
The present invention prepares the technology of pelletron owing to used berberine as active drug, thereby biological activity is stable, to nontoxic pair of effect of human body and anaphylaxis.So and since the berberine powder be scattered in the coralliform micropore of solid matrix equably among berberine can slowly release.With the made product of the technology of above-mentioned example 1, measure proof through the measuring degree and in external 37 ℃ ± 0.5 ℃ normal saline medium, still have drug release after 50 days; Through animal (rabbit) evidence,, there is not inflammatory cell infiltration to the heart, lung, liver, kidney and local all untoward reaction such as avirulence, allergy yet; The tangible bacteriostasis that staphylococcus aureus, colibacillus, green dense liver bacterium, B-mode chain pearl bacterium etc. is all had the long period through the bacteriostatic test proof.From in October, 88, all obtained good therapeutic effect in the prevention of treatment chronic osteomyelitis, fistula, sinus tract, deep soft tissue's infection, traumatic infection and open fracture infection through clinical practice.Because the pearl in embodiment 2 technologies is ellipse garden shape, so when being used for the myelitic dead space of fistula or sinus tract or part and being elongated shape, be convenient to extract.Owing to have the wound that several holes can be used for actute infection, example on the pearl of the pelletron in embodiment 3 technologies: abscess is cut row's postoperative soft tissue actute infection etc., is beneficial to the medicine rapid release and forms high local concentrations.Owing to cost of material among the present invention is low, preparation technology is simple again, thereby the cost price of every string (26 pearls) is 0.20～0.30 a yuan/string.
Claims (2)
1, a kind of preparation technology who is used for the treatment of the pelletron of treatment usefulness behind chronic osteomyelitis, trauma infection contamination, deep soft tissue's infection and bone, the surgical operation, with active drug and polymethyl methacrylate polymer and polymethyl methacrylate monomer is that raw material mixes, transfer to dough period not, pour into by giving of preparing of pelletron shape need design and be embedded with in the mould wiry that human body is not reacted, solidify, the demoulding forms, and it is characterized in that: use berberine powder as the active drug composition.
2, according to the preparation technology of claim 1 described medical pelletron, it is characterized in that: the proportioning of berberine powder and polymethyl methacrylate polymer is 0.5: 2-5: the 1(weight ratio).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104306 CN1048157A (en) | 1989-06-21 | 1989-06-21 | A kind of preparation technology of medical pelletron |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104306 CN1048157A (en) | 1989-06-21 | 1989-06-21 | A kind of preparation technology of medical pelletron |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1048157A true CN1048157A (en) | 1991-01-02 |
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ID=4855507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89104306 Pending CN1048157A (en) | 1989-06-21 | 1989-06-21 | A kind of preparation technology of medical pelletron |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1048157A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050048C (en) * | 1993-07-10 | 2000-03-08 | 宋爱民 | Jiedufugugao adhesive plaster for medullitis |
| CN1060056C (en) * | 1994-12-04 | 2001-01-03 | 崔树闰 | "Guyankang" adhesive plaster for curing osteomyelitis |
| CN102429493A (en) * | 2011-07-21 | 2012-05-02 | 刘振躬 | Carbon healthcare mattress and processing method |
| CN104207829A (en) * | 2014-09-03 | 2014-12-17 | 吉林大学 | Antibiotic bone cement chain bead manufacturer and method |
| US10080688B2 (en) | 2012-10-16 | 2018-09-25 | Surmodics, Inc. | Wound packing device and method |
| US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
-
1989
- 1989-06-21 CN CN 89104306 patent/CN1048157A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050048C (en) * | 1993-07-10 | 2000-03-08 | 宋爱民 | Jiedufugugao adhesive plaster for medullitis |
| CN1060056C (en) * | 1994-12-04 | 2001-01-03 | 崔树闰 | "Guyankang" adhesive plaster for curing osteomyelitis |
| CN102429493A (en) * | 2011-07-21 | 2012-05-02 | 刘振躬 | Carbon healthcare mattress and processing method |
| US10080688B2 (en) | 2012-10-16 | 2018-09-25 | Surmodics, Inc. | Wound packing device and method |
| US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
| CN104207829A (en) * | 2014-09-03 | 2014-12-17 | 吉林大学 | Antibiotic bone cement chain bead manufacturer and method |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |