CN204106163U - A kind of antibiotic-loaded bone cement chain pearl manufactures device - Google Patents

Abstract

The utility model discloses an antibiotic bone cement chain bead maker, which comprises an upper mold and a lower mold, and the upper mold includes the upper half (1) of a wire groove, a first positioning pin (2), and an upper half of an air vent. Part (3), upper part of the side hole (4), upper part of the rosary model hole (5), the second positioning pin (6), the upper shape and the lower shape are completely symmetrical, and the first positioning pins on both sides (2) and the second positioning pin (6) are located on the diagonal, the lower pattern includes the lower half of the side hole (7), the lower half of the rosary model hole (8), the first positioning pin slot (9), the exhaust The lower half of the hole (10), the second positioning pin slot (11), and the lower half of the wire slot (12). The utility model has the characteristics of simple structure and convenient operation, and is suitable for popularization and application.

Description

An antibiotic bone cement bead maker

technical field

The utility model belongs to the technical field of medicine and relates to an antibiotic bone cement chain bead maker.

Background technique

Antibiotic bone cement beads are an effective drug delivery system for the treatment of bone and soft tissue infections.

In 1974, Klemm made rosary beads with bone cement mixed with gentamicin for the first time, and temporarily filled them into the dead space after debridement of infected bone. In 128 cases of chronic osteomyelitis, the reported cure rate was 91.4%. In patients with chronic osteomyelitis or open fractures leading to bone defects, temporary (weeks to months) placement of antibiotic bone cement beads into the dead space of debridement bone can provide high local concentrations of antibiotics. If necessary, combined with systemic antibiotics, after fresh granulation was formed, the beads were removed and bone grafted.

Bone cement is generally polymerized polymethyl methacrylate (PMMA). Before use, it is divided into powdered bone cement polymer and aqueous methyl methacrylate. The two are mixed for 5-10 minutes to polymerize into a viscous substance. When antibiotics are used in combination, the antibiotic powder and bone cement powder must be mixed thoroughly before adding water agent. The bone cement is molded into a small diameter ball, which is the rosary. Rosary beads can be used singly or in multiples strung with sutures (that is, chain beads).

Studies by Elson et al. have shown that if the antibiotic-loaded polymethylmethacrylate (PMMA) is placed close to the cortical bone, the antibiotic can penetrate the dense cortical bone, and the concentration in the bone is higher than that of systemic medication within the safe range. Animal and human studies of the penetration of antibiotics from bone cement or rosary into adjacent tissues have found that in hematoma, wound exudate, granulation tissue, and bone, the concentration of antibiotics varies with the type of antibiotic, but the antibiotic is long-lasting and the concentration is higher than that in serum The measured value in and above the minimum inhibitory concentration (MIC) breakpoint. During emergency debridement of severe open fractures, if the range of inactivated tissue is not clear, as an adjuvant therapy, adding antibiotic bone cement to temporarily fill the dead space can reduce local bacteria and avoid infection. Ostermann et al. reported that after the same debridement, fixation, and systemic antibiotics, the overall infection rate of the rosary group was significantly lower than that of the no rosary group. Antibiotic bone cement bead chains, as a drug sustained-release system, can continuously release high-concentration antibiotics in local tissues, and the blood drug concentration is very low. Phase bone graft. The safety of this usage has been demonstrated, with topical antibiotic cement and beads producing significantly less side effects than systemic antibiotics, including immune reactions.

In recent years, antibiotic bone cement chain beads have been widely used clinically, mostly for the prevention of infection in open fractures and the treatment of infectious orthopedic diseases such as osteomyelitis. Its production method is mostly to use thin steel wire or thick wire as the wire, mix it with bone cement containing antibiotics, wait until the dough is frozen on the wire, completely harden, and use it after cooling. The production method is relatively cumbersome and takes a long time, and the handmade can not guarantee the uniformity of the beads. It is difficult to implant in the relatively narrow bone marrow cavity, and if the beads of different sizes are taken out from the wound, it will bring great pain to the patient. .

Utility model content

In order to overcome the defects in the prior art, the utility model provides an antibiotic bone cement bead maker, which can simplify the manufacturing steps and manufacture rosary beads of uniform size based on a mold. Its technical scheme is as follows:

An antibiotic bone cement chain bead maker, comprising an upper mold and a lower mold, the upper mold includes the upper half 1 of the clamping groove, the first positioning pin 2, the upper half 3 of the vent hole, and the upper half 4 of the side hole , the upper half of the rosary model hole 5, the second positioning pin 6, the upper pattern and the lower pattern are completely symmetrical, the first positioning pin 2 and the second positioning pin 6 on both sides are located on the diagonal, and the lower pattern includes side holes The lower part 7, the lower part of the rosary model hole 8, the first positioning pin slot 9, the lower part of the air vent 10, the second positioning pin slot 11, the lower half of the wire slot 12, the upper half of the wire slot Part 1 is combined with the lower part 12 of the wire slot to form a wire slot, the upper part 4 of the side hole is combined with the lower part 7 of the side hole to form a side hole, and the upper part 5 of the rosary model hole is combined with the lower part of the rosary model hole 8 are combined to form a rosary model hole, the upper part 3 of the vent hole is combined with the lower part 10 of the vent hole to form a vent hole, and the first positioning pin 2 is combined with the first positioning pin slot 9 to form the first positioning pin , The second positioning pin 6 is matched with the second positioning pin slot 11 to form a second positioning pin.

Preferably, the maker is 197mm in length, 25mm in width, 1mm in diameter of the clamping groove, the bead model is ellipsoidal in shape with a long diameter of 12mm, a short diameter of 7mm, a bead spacing of 7mm, a side hole diameter of 2mm, and a side vent hole diameter of 1mm .

Beneficial effects of the utility model: the antibiotic bone cement bead maker of the utility model is simple in structure, easy to operate, can simplify the manufacturing steps, and can manufacture rosary beads of uniform size based on the mold. The rosary is small in size and ellipsoidal in shape, with a long diameter of 12mm and a short diameter of 7mm. The distance between the rosary beads is 7mm. The range of motion is large. It can be implanted in any part. It is easy to take out and can reduce the pain of patients. The cost is lower than that of commercial chain beads. The number of internal production is large. The finished chain beads have 10 beads per string, and the number of beads can be randomly adjusted according to the needs of the connection.

Description of drawings

Fig. 1 is the structural schematic diagram of the pattern on the utility model antibiotic bone cement bead maker;

Fig. 2 is the structure schematic diagram of the lower shape of the antibiotic bone cement bead maker of the utility model;

Fig. 3 is the schematic diagram of the mold parameters after the combination;

Figure 4 is a mold drawing.

Detailed ways

The technical solution of the present utility model will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

Referring to Fig. 1-Fig. 4, an antibiotic bone cement chain bead manufacturer includes an upper pattern and a lower pattern, and the upper pattern includes the upper part 1 of the wire groove, the first positioning pin 2, and the upper part 3 of the vent hole , the upper part of the side hole 4, the upper part of the rosary model hole 5, the second positioning pin 6, the upper and lower shapes are completely symmetrical, the first positioning pin 2 and the second positioning pin 6 on both sides are located on the diagonal, The lower pattern includes the lower part 7 of the side hole, the lower part 8 of the rosary model hole, the first positioning pin slot 9, the lower part 10 of the exhaust hole, the second positioning pin slot 11, and the lower half of the wire slot 12. The upper part 1 of the thread clamping groove is combined with the lower part 12 of the thread retaining groove to form a thread retaining groove, the upper part 4 of the side hole is combined with the lower part 7 of the side hole to form a side hole, and the upper part of the rosary model hole 5 Combined with the lower part 8 of the rosary model hole to form a rosary model hole, the upper part 3 of the vent hole and the lower part 10 of the vent hole are combined to form a vent hole, the first positioning pin 2 and the first positioning pin slot 9 The first positioning pin is formed by being combined, and the second positioning pin 6 is combined with the second positioning pin slot 11 to form a second positioning pin.

Preferably, the maker is 197mm in length, 25mm in width, 1mm in diameter of the clamping groove, the bead model is ellipsoidal in shape with a long diameter of 12mm, a short diameter of 7mm, a bead spacing of 7mm, a side hole diameter of 2mm, and a side vent hole diameter of 1mm .

The utility model comprises the following steps in the specific application process:

Step 1: Mix antibiotic powder and bone cement polymer according to the required ratio;

Step 2: Add water-based methyl methacrylate for reconciliation, and adjust the mixture to a liquid state or to a dough stage;

Step 3: If the mixture has entered the dough stage, apply the mixture directly to the bead model holes of the two parts of the mold, press the wire into the clamping groove, fit the mold, and lock the positioning pin; if the mixture is in a viscous liquid state, First place the wire in the clamping groove, match the mold, lock the positioning pin, pour the mixture into the syringe and inject it into the mold from the side hole;

Step 4: After the bone cement exothermic period, the chain beads have been formed and hardened, the positioning pins are opened, the mold is removed, and the corresponding repairs are carried out to remove redundant edges, that is, the chain beads are manufactured.

After the exothermic period of the bone cement, the chain beads have formed and hardened. Open the positioning pin and remove the mold. The prototype of the chain beads can be seen. Repair the prototype of the chain beads and remove the redundant edges to form the chain beads. The formed chain beads are formed by the mousse wire as the wire , the activity can be placed in any position.

The above is only a preferred embodiment of the utility model, and the scope of protection of the utility model is not limited thereto. Anyone familiar with the technical field can obviously obtain the technology within the technical scope disclosed in the utility model. Simple changes or equivalent replacements of the schemes all fall within the protection scope of the present utility model.

Claims (2)

1. an antibiotic-loaded bone cement chain pearl manufactures device, it is characterized in that, comprise apperance and lower apperance, described upper apperance comprises cable clamping interface the first half (1), first alignment pin (2), steam vent the first half (3), side opening the first half (4), beads-on-a-string hole the first half (5), second alignment pin (6), upper apperance and lower apperance full symmetric, first alignment pin (2) and second alignment pin (6) of both sides are positioned on diagonal, described lower apperance comprises side opening the latter half (7), beads-on-a-string hole the latter half (8), first alignment pin draw-in groove (9), steam vent the latter half (10), second alignment pin draw-in groove (11), cable clamping interface the latter half (12), cable clamping interface the first half (1) and cable clamping interface the latter half (12) are combined to form cable clamping interface, side opening the first half (4) and side opening the latter half (7) are combined to form side opening, beads-on-a-string hole the first half (5) and beads-on-a-string hole the latter half (8) are combined to form beads-on-a-string hole, steam vent the first half (3) and steam vent the latter half (10) are combined to form steam vent, first alignment pin (2) and the first alignment pin draw-in groove (9) are combined to form the first alignment pin, second alignment pin (6) and the second alignment pin draw-in groove (11) are combined to form the second alignment pin.

2. antibiotic-loaded bone cement chain pearl according to claim 1 manufactures device, it is characterized in that, the long 197mm of described manufacture device, wide 25mm, cable clamping interface diameter 1mm, beads-on-a-string is its major diameter of spheroid shape 12mm, minor axis 7mm, beads spacing 7mm, side opening diameter 2mm, side-exhaustion bore dia 1mm.