CN104771781A - Liquid wound protection film and preparation method thereof - Google Patents
Liquid wound protection film and preparation method thereof Download PDFInfo
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- CN104771781A CN104771781A CN201410413691.8A CN201410413691A CN104771781A CN 104771781 A CN104771781 A CN 104771781A CN 201410413691 A CN201410413691 A CN 201410413691A CN 104771781 A CN104771781 A CN 104771781A
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Abstract
The invention discloses a liquid wound protection film. The liquid wound protection film is prepared from 70-80wt% of anhydrous ethanol, 4-6wt% of ethyl acetate, 3-5wt% of butyl acetate, 2-4wt% of ethyl butyrate, 8-15wt% of cellulose acetate, 0.1-0.5wt% of chlorhexidine, 0.5-1.5wt% of natural borneol, 0.1-0.5wt% of pseudo-ginseng extract, 0.2-0.4wt% of turmeric extract and 0.1-0.3wt% of dragon's blood extract. The liquid wound protection film has good film forming ability after smearing, has good effects of stopping bleeding, easing pain, relieving itching, inhibiting bacteria and resisting water, has no adverse smell, can be accepted by the public easily and is an ideal wound protection material.
Description
Technical field
The present invention relates to biomedical materials field.Particularly relate to a kind of fast-drying type liquid Wound surface protection film and preparation method thereof.
Background technology
In daily life, people are because the skin injury that mosquito bite, scratch, incised wound, scuffing etc. cause is all the problem that often can occur.For problems, we adopt the adhesive bandage of menthocamphorate, floral water or routine to solve.And adhesive bandage owing to there is poor air permeability, non-watertight, unsightly, joint part is difficult to problems such as fixing, people are not very inconvenient in use.
For the problems referred to above that adhesive bandage exists, at present both at home and abroad also You Shuo company starts production and sales liquid adhesive bandage series products, and these liquid adhesive bandage series products are owing to have employed nitrocellulose as filmogen, and owing to there is inflammable and explosive characteristic in this material of nitrocellulose, there is certain hidden danger in safety, producer is also had to use single acetone or ethyl acetate as cosolvent in addition, the smell is awful, and there is certain toxicity, especially larger for infant, child and anemia of pregnant woman's injury.Having and do not have adhesive bandage series products that is a kind of and that do not affect the appearance safely, is the problem that the applicant needs to solve.
Summary of the invention
In order to solve that existing adhesive bandage and class adhesive bandage exist non-watertight, unsightly, joint part is difficult to fix; and there is the safety risks such as inflammable and explosive in nitrocellulose; and acetone or ethyl acetate are as cosolvent; the smell is awful; there is the problem of certain toxicity, the invention provides a kind of attractive in appearance, safe, nontoxic fast-drying type liquid Wound surface protection film
To achieve these goals, the technical solution used in the present invention is: a kind of liquid Wound surface protection film, it is characterized in that, liquid Wound surface protection film is mixed by ethanol, ethyl acetate, butyl acetate, ethyl n-butyrate., cellulose acetate, hibitane, Borneolum Syntheticum, Radix Notoginseng extract, Rhizoma Curcumae Longae extract and Sanguis Draxonis extract; In liquid Wound surface protection film, the percentage by weight of each composition is: dehydrated alcohol 70%-80%; Ethyl acetate 4%-6%; Butyl acetate 3%-5%; Ethyl n-butyrate. 2%-4%; Cellulose acetate 8%-15%; Hibitane 0,1%-0,5%; Natural Broneolum Syntheticum 0,5%-1,5%; Radix Notoginseng extract 0,1%-0,5%; Rhizoma Curcumae Longae extract 0,2%-0,4%; Sanguis Draxonis extract 0,1%-0,3%.
A preparation method for liquid Wound surface protection film, comprises the steps:
1), dehydrated alcohol 700g-800g, ethyl acetate 40g-60g, butyl acetate 30g-50g, ethyl n-butyrate. 20g-40g are mixed.
2), in step (1) gained mixed liquor, add cellulose acetate 80g-150g after, be heated to 40 DEG C-50 DEG C and stirring at low speed and dissolve completely to cellulose acetate.
3), in step (2) gained mixed liquor hibitane 1g-5g is added successively, natural Broneolum Syntheticum 5g-15g, Radix Notoginseng extract 1g-5g, Rhizoma Curcumae Longae extract 2g-4g and Sanguis Draxonis extract 1g-3g; Stirring makes it to dissolve completely.
4), by after step (3) gained mixed liquor static layering, steel mesh is used to filter.
5), the liquid of step (4) gained can be obtained liquid Wound surface protection film finished product by filling machine subpackage.
Further, the described static layering time is 24H.
Further, described steel mesh is the steel mesh that Stainless steel 316 obtains.
Further, described rustless steel steel mesh is 800 orders.
After adopting technical scheme of the present invention; this liquid Wound surface protection film has quick sterilization effect; wherein the quick sterilization effect of ethanol is obvious; the long-acting bacteriostatic effect of hibitane is remarkable; Borneolum Syntheticum can ease pain, and the protecting film formed after ethanol volatilization has certain toughness, has significant waterproof and breathable and protective action; Radix Notoginseng extract can stop blooding by quickly easing pain, and Rhizoma Curcumae Longae extract and Sanguis Draxonis extract can synergic antalgic hemostasis.The beneficial effect of this product: liquid Wound surface protection film has the distinguishing features such as abnormal smells from the patient is pleasant, fast filming, effectively analgesia, long-acting bacteriostatic, and the raw materials used medical grade products that is, Product Safety is good.Compared with similar products, there is the features such as raw material is safer, abnormal smells from the patient significantly improves.
Specific embodiment
The description of following examples is intended to explain principle of the present invention and principal character, does not have concrete restriction effect to the raw material composition in the present invention, ratio.
Embodiment 1
First by the dehydrated alcohol 700g bottle of falling filament inlet.Then add ethyl acetate 40g respectively, butyl acetate 40g, after ethyl n-butyrate. 40g, seal mix homogeneously.And then after adding cellulose acetate 140g sealing; the silk mouth bottle that mixed liquor is housed is placed in 40 DEG C of warm water and carries out water-bath maintenance; the movable wire mouth bottle that simultaneously shakes makes cellulose acetate wherein dissolve in mixed liquor completely; and then add hibitane 3g respectively; Borneolum Syntheticum 15g; Radix Notoginseng extract 5g; Rhizoma Curcumae Longae extract 4g; Sanguis Draxonis extract 3g; static 24h after mix homogeneously; again by 800 object Stainless steel 316 strainer filterings, by the liquid after filtration by namely obtaining liquid Wound surface protection film finished product after filling machine subpackage.
The liquid Wound surface protection film related test results that embodiment 1 obtains contrasts as follows with country and industry correlation standard:
Above-mentioned data show, freshly prepared liquid Wound surface protection film meets relevant industry standard completely.Film formation time, within the scope that permeability and power viscosity number all specify in industry, content of beary metal is well below industry standard value simultaneously, belongs to a kind of attractive in appearance, safe, nontoxic fast-drying type liquid Wound surface protection film.
Embodiment 2
First by the dehydrated alcohol 800g bottle of falling filament inlet.Then add ethyl acetate 50g respectively, butyl acetate 30g, after ethyl n-butyrate. 20g, seal mix homogeneously.And then after adding cellulose acetate 850g sealing; the silk mouth bottle that mixed liquor is housed is placed in 45 DEG C of warm water and carries out water-bath maintenance; the movable wire mouth bottle that simultaneously shakes makes cellulose acetate wherein dissolve in mixed liquor completely; and then add hibitane 3g respectively; Borneolum Syntheticum 5g; Radix Notoginseng extract 3g; Rhizoma Curcumae Longae extract 2g; Sanguis Draxonis extract 2g; static 24h after mix homogeneously; again by 800 object Stainless steel 316 strainer filterings, by the liquid after filtration by namely obtaining liquid Wound surface protection film finished product after filling machine subpackage.
The liquid Wound surface protection film related test results that embodiment 2 obtains contrasts as follows with country and industry correlation standard:
Above-mentioned data show, freshly prepared liquid Wound surface protection film meets relevant industry standard completely.Film formation time, within the scope that permeability and power viscosity number all specify in industry, content of beary metal is well below industry standard value simultaneously, belongs to a kind of attractive in appearance, safe, nontoxic fast-drying type liquid Wound surface protection film.
Claims (5)
1. a liquid Wound surface protection film, is characterized in that, liquid Wound surface protection film is mixed by ethanol, ethyl acetate, butyl acetate, ethyl n-butyrate., cellulose acetate, hibitane, Borneolum Syntheticum, Radix Notoginseng extract, Rhizoma Curcumae Longae extract and Sanguis Draxonis extract; In liquid Wound surface protection film, the percentage by weight of each composition is: dehydrated alcohol 70%-80%; Ethyl acetate 4%-6%; Butyl acetate 3%-5%; Ethyl n-butyrate. 2%-4%; Cellulose acetate 8%-15%; Hibitane 0,1%-0,5%; Natural Broneolum Syntheticum 0,5%-1,5%; Radix Notoginseng extract 0,1%-0,5%; Rhizoma Curcumae Longae extract 0,2%-0,4%; Sanguis Draxonis extract 0,1%-0,3%.
2. a preparation method for liquid Wound surface protection film, is characterized in that comprising the steps:
1), dehydrated alcohol 700g-800g, ethyl acetate 40g-60g, butyl acetate 30g-50g, ethyl n-butyrate. 20g-40g are mixed;
2), in step (1) gained mixed liquor, add cellulose acetate 80g-150g after, be heated to 40 DEG C-50 DEG C and stirring at low speed and dissolve completely to cellulose acetate;
3), in step (2) gained mixed liquor hibitane 1g-5g is added successively, natural Broneolum Syntheticum 5g-15g, Radix Notoginseng extract 1g-5g, Rhizoma Curcumae Longae extract 2g-4g and Sanguis Draxonis extract 1g-3g; Stirring makes it to dissolve completely;
4), by after step (3) gained mixed liquor static layering, steel mesh is used to filter;
5), the liquid of step (4) gained can be obtained liquid Wound surface protection film finished product by filling machine subpackage.
3. the preparation method of liquid Wound surface protection film according to claim 2, is characterized in that: the described static layering time is 24h.
4. the preparation method of liquid Wound surface protection film according to claim 2, is characterized in that: described steel mesh is the steel mesh that Stainless steel 316 obtains.
5. the preparation method of liquid Wound surface protection film according to claim 2, is characterized in that: described rustless steel steel mesh is 800 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410413691.8A CN104771781A (en) | 2014-08-20 | 2014-08-20 | Liquid wound protection film and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410413691.8A CN104771781A (en) | 2014-08-20 | 2014-08-20 | Liquid wound protection film and preparation method thereof |
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| CN104771781A true CN104771781A (en) | 2015-07-15 |
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| CN201410413691.8A Pending CN104771781A (en) | 2014-08-20 | 2014-08-20 | Liquid wound protection film and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924803A (en) * | 2017-05-05 | 2017-07-07 | 江南大学 | A kind of high-performance medical use liquid adhesive bandage and preparation method thereof |
| CN107693840A (en) * | 2016-08-09 | 2018-02-16 | 北京纳通医学科技研究院有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN110201220A (en) * | 2019-05-29 | 2019-09-06 | 利安隆博华（天津）医药化学有限公司 | A kind of liquid adhesive bandage and preparation method thereof improving osmotic absorption rate |
| CN110975004A (en) * | 2019-12-10 | 2020-04-10 | 中山大学新华学院 | A liquid woundplast containing Notoginseng radix extract for rapidly forming film |
| CN114504567A (en) * | 2022-03-01 | 2022-05-17 | 云南云河药业股份有限公司 | Dragon's blood liquid adhesive bandage and preparation method thereof |
| EP4378311A1 (en) * | 2022-11-30 | 2024-06-05 | Barna Import Medica, S.A. | Coloured chlorhexidine compositions |
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| CN1514706A (en) * | 2001-01-09 | 2004-07-21 | ��˹���������дĻ� | Therapeutic film-forming compositions and therapeutic systems thereof |
| CN1546176A (en) * | 2003-12-17 | 2004-11-17 | 苗九昌 | Stealth water-proof spray paste for wound |
| CN102166369A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Liquid woundplast and preparation technology thereof |
| US20140154188A1 (en) * | 2011-03-25 | 2014-06-05 | Laboratoires Urgo | Composition containing a cellulose, a vegetable oil and a volatile solvent, and use threof as a dressing |
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2014
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Patent Citations (4)
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| CN1546176A (en) * | 2003-12-17 | 2004-11-17 | 苗九昌 | Stealth water-proof spray paste for wound |
| CN102166369A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Liquid woundplast and preparation technology thereof |
| US20140154188A1 (en) * | 2011-03-25 | 2014-06-05 | Laboratoires Urgo | Composition containing a cellulose, a vegetable oil and a volatile solvent, and use threof as a dressing |
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| JAN SCHUREN等: ""A liquid film-forming acrylate for peri-wound protection: a systematic review and meta-analysis(3MTM CavilonTM no-sting barrier film)"", 《INTERNATIONAL WOUND JOURNAL》 * |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693840A (en) * | 2016-08-09 | 2018-02-16 | 北京纳通医学科技研究院有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN106924803A (en) * | 2017-05-05 | 2017-07-07 | 江南大学 | A kind of high-performance medical use liquid adhesive bandage and preparation method thereof |
| CN110201220A (en) * | 2019-05-29 | 2019-09-06 | 利安隆博华（天津）医药化学有限公司 | A kind of liquid adhesive bandage and preparation method thereof improving osmotic absorption rate |
| CN110975004A (en) * | 2019-12-10 | 2020-04-10 | 中山大学新华学院 | A liquid woundplast containing Notoginseng radix extract for rapidly forming film |
| CN114504567A (en) * | 2022-03-01 | 2022-05-17 | 云南云河药业股份有限公司 | Dragon's blood liquid adhesive bandage and preparation method thereof |
| CN114504567B (en) * | 2022-03-01 | 2023-10-20 | 云南云河药业股份有限公司 | Dragon blood liquid adhesive bandage and preparation method thereof |
| EP4378311A1 (en) * | 2022-11-30 | 2024-06-05 | Barna Import Medica, S.A. | Coloured chlorhexidine compositions |
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Application publication date: 20150715 |
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