CN104740320A - Traditional Chinese medicine composition for treating acne and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating acne. The traditional Chinese medicine composition is a preparation prepared from the following raw pharmaceutical materials in parts by weight: 16-22 parts of peach blossom, 15-25 parts of white gourd seeds, 18-23 parts of excrementum passeris, 15-25 parts of rhizoma pleionis, 15-25 parts of polyphylla rhizoma paridis, 40-60 parts of salvia miltiorrhiza, 40-60 parts of dahurian angelica root, 15-25 parts of cortex dictamni, 8-13 parts of sulfur powder, 10-18 parts of radix scutellariae, 12-18 parts of gardenia, 12-20 parts of honeysuckle flower, 15-30 parts of pearl powder and 15-25 parts of mung beans. The invention further provides a preparation method and use of the traditional Chinese medicine composition. According to the traditional Chinese medicine composition provided by the invention, the compatibility is precise and appropriate, and all medicines supplement each other, so that the traditional Chinese medicine composition has a remarkable treatment effect on relieving the state of illness of patients suffering from acne, particularly stubborn acne including suppurative and cystic acne, can be used for effectively treating sputum and stasis combined acne in traditional Chinese medicine, and has certain treatment effects on the prevention and treatment of recurrence of acne and the relief of recurrent symptoms.

Description

A kind of traditional Chinese medicine composition for treating acne and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine composition for treating acne and a preparation method thereof, belonging to the field of traditional Chinese medicines.

Background technique

Acne is a clinically common chronic pilosebaceous gland inflammatory skin disease, which is called "lung wind acne", "wine thorn" etc. in traditional Chinese medicine. Acne generally occurs on the face, chest and back of young men and women, and its characteristic skin lesions are papules, blackheads, whiteheads, pustules, and nodules consistent with hair follicles. Acne further develops into various inflammatory skin lesions, manifested as inflammatory papules, pustules, nodules and cysts. Pigmentation, persistent erythema, depressed or hypertrophic scars are often left behind after the inflammatory lesions subside, resulting in The condition is stubborn and lingering. Acne is the most common skin disease that affects beauty among young people. Patients are prone to psychological problems such as impaired self-confidence, embarrassment, and depression, resulting in social and employment barriers.

The etiology and pathogenesis of acne are complex. Western medicine believes that it is a multifactorial disease, which is mainly related to androgen, increased sebum secretion, microorganisms, inflammatory damage, immunity, heredity, environment, and daily life habits. Traditional Chinese medicine believes that this disease is often caused by internal heat and exogenous pathogenic factors. According to TCM syndrome differentiation, it can be divided into three types: wind-heat in the lung meridian, damp-heat in the stomach, and mixed phlegm and blood stasis.

At present, retinoic acid drugs, antibiotics, hormones, etc. are often used clinically to treat acne. The early curative effect is acceptable, but it lacks curative effect on cysts and scars in the later stage of acne, and has many side effects and easy recurrence. Traditional Chinese medicine has an outstanding curative effect on this disease, but intractable acne has a long treatment cycle for local lesions because of its deep evil. Therefore, it is an urgent need for acne patients to develop a safe and effective product for treating acne, especially intractable acne.

Contents of the invention

The object of the present invention is to provide a traditional Chinese medicine composition which can safely and effectively treat acne, its preparation method and application.

The invention provides a traditional Chinese medicine composition for treating acne, which is a preparation prepared from raw materials containing the following weight ratios:

16-22 parts of peach blossom, 15-25 parts of winter melon seeds, 18-23 parts of white clove, 15-25 parts of Shanzi mushroom, 15-25 parts of Chonglou, 40-60 parts of salvia miltiorrhiza, 40-60 parts of Angelica dahurica, white fresh skin 15-25 parts, 8-13 parts of sulfur powder, 10-18 parts of skullcap, 12-18 parts of gardenia, 12-20 parts of silver flower, 15-30 parts of pearl powder, 15-25 parts of mung bean.

Further preferably, it is a preparation prepared from raw materials in the following weight ratio:

16-22 parts of peach blossom, 15-25 parts of winter melon seeds, 18-23 parts of white clove, 15-25 parts of Shanzi mushroom, 15-25 parts of Chonglou, 40-60 parts of salvia miltiorrhiza, 40-60 parts of Angelica dahurica, white fresh skin 15-25 parts, 8-13 parts of sulfur powder, 10-18 parts of skullcap, 12-18 parts of gardenia, 12-20 parts of silver flower, 15-30 parts of pearl powder, 15-25 parts of mung bean.

More preferably, it is a preparation prepared from raw materials in the following weight ratio:

20 parts of peach blossom, 20 parts of winter melon seeds, 20 parts of white clove, 20 parts of Shanzi mushroom, 20 parts of Chonglou, 40 parts of salvia miltiorrhiza, 40 parts of angelica dahurica, 20 parts of white moss bark, 10 parts of sulfur powder, 15 parts of skullcap, gardenia 15 parts, silver flower 15 parts, pearl powder 20 parts, mung beans 20 parts.

The composition of the present invention is composed of peach blossom, wax gourd seeds, white clove, mountain Arrowhead, chrysanthemum, salvia miltiorrhiza, angelica, white fresh skin, sulfur powder, scutellaria baicalensis, gardenia, silver flower, pearl powder, mung bean, or water. Or an external preparation prepared by adding pharmaceutically acceptable adjuvants or auxiliary ingredients as the active ingredient with an organic solvent extract. Wherein, the auxiliary component is vitamin A acid.

Wherein, the dosage form of the external preparation is tincture, ointment, gel, lotion, liniment, emulsion, film.

The present invention also provides a kind of preparation method of described Chinese medicine composition, and it comprises the steps:

a, take the raw material medicine of each weight ratio;

b. External preparation prepared by powdering or adding water or organic solvent for extraction, and adding pharmaceutically acceptable excipients or auxiliary ingredients.

Wherein, the organic solvent is ethanol.

The invention also provides the application of the traditional Chinese medicine composition in the preparation of medicines or cosmetics with the effect of treating acne.

Wherein, the acne is intractable acne, such as pustular acne and cystic acne.

Furthermore, the acne is acne of phlegm and blood stasis in traditional Chinese medicine.

The traditional Chinese medicine composition provided by the present invention is well compatible, and the flavors of the medicines complement each other. It has a significant effect on relieving acne, especially intractable acne, including suppurative and cystic acne, and can improve acne cysts and scars, and effectively treat the phlegm and blood stasis in traditional Chinese medicine. acne. It has a certain effect on the prevention and treatment of acne recurrence and the relief of symptoms after recurrence. Moreover, the traditional Chinese medicine composition of the present invention uses natural Chinese herbal medicines as raw materials and can be used safely.

Detailed ways

The following examples are used for further description, but the present invention is not limited to these examples.

Embodiment 1 facial mask preparation of the present invention

Prescription: 20g of peach blossom, 20g of winter melon seeds, 20g of white clove, 20g of Shanzi mushroom, 20g of Chonglou, 40g of salvia miltiorrhiza, 40g of angelica dahurica, 20g of white moss skin, 10g of sulfur powder, 15g of skullcap, 15g of gardenia, 15g of silver flower, pearl powder 20g, mung beans 20g.

Preparation:

Weigh the above-mentioned traditional Chinese medicine ingredients according to the weight ratio, grind them into powder, control the particle size at 50-90um after crushing, put them in a container, add 2-3 egg yolks and stir evenly, then add 100ml of honey, 400ml of pure water, stir evenly and serve The facial mask of the present invention can be obtained.

Instructions:

Apply the above prepared medicine evenly on the face, and after about 20 minutes, rinse it off with clean water.

Embodiment 2 ointment preparation of the present invention

(1) Use 50g of glycerin, 100g of stearic acid, 30g of triethanolamine, 100g of liquid paraffin, 60g of paraffin, 10g of ethylparaben, and 500ml of pure water as auxiliary materials, which are acceptable to the human body. After heating and melting, stir evenly and condense, An ointment-type base can be obtained.

(2) each Chinese medicine composition is taken by following weight ratio: peach blossom 20g, wax gourd seed 20g, white clove 20g, mountain arrowhead 20g, polyphyllum 20g, salvia miltiorrhiza 40g, angelica dahurica 40g, white moss bark 20g, sulfur powder 10g, Scutellaria baicalensis 15g, gardenia 15g, silver flower 15g, pearl powder 20g, mung bean 20g.

Add water or obtain the extract after pulverizing the traditional Chinese medicine components, dry, pulverize again, and control the pulverized particle size to 50-90um, and then the active ingredient raw material drug can be obtained.

(3) Add the crude drug obtained in (2) into the matrix obtained in (1) and stir well to make an ointment preparation.

How to use: Apply the ointment prepared above evenly on the face, and rinse it off with water after about 20 minutes.

Embodiment 3 preparation of emulsifiable paste of the present invention

(1) 50 g of polyacrylic acid, 5 g of triethanolamine, 2 g of disodium edetate, 200 g of propylene glycol, 2 g of benzoic acid, and 500 ml of pure water are placed in a container, heated and melted, stirred evenly and condensed to obtain a cream base;

(2) each Chinese medicine composition is taken by following weight ratio: peach blossom 20g, wax gourd seed 20g, white clove 20g, mountain arrowhead 20g, polyphyllum 20g, salvia miltiorrhiza 40g, angelica dahurica 40g, white moss bark 20g, sulfur powder 10g, Scutellaria baicalensis 15g, gardenia 15g, silver flower 15g, pearl powder 20g, mung bean 20g.

The traditional Chinese medicine components are pulverized, then extracted with ethanol to obtain the extract, dried, pulverized again, and the pulverized particle size is controlled at 50-90um, so that the active ingredient raw material medicine can be obtained.

(3) Add (2) into (1) and stir thoroughly to prepare a cream preparation.

How to use: Apply the cream preparation prepared above evenly on the face, and after about 20 minutes, rinse it off with clean water.

The liniment preparation of embodiment 4 Chinese medicine composition of the present invention

(1) Put 200ml of ethanol (95%), 20g of phenol, 50g of boric acid, and 500ml of pure water in a container, heat to dissolve, stir evenly and then cool, then it can be used as a disinfectant auxiliary material;

(2) each Chinese medicine composition is taken by following weight ratio: peach blossom 20g, wax gourd seed 20g, white clove 20g, mountain arrowhead 20g, polyphyllum 20g, salvia miltiorrhiza 40g, angelica dahurica 40g, white moss bark 20g, sulfur powder 10g, Scutellaria baicalensis 15g, gardenia 15g, silver flower 15g, pearl powder 20g, mung bean 20g.

The traditional Chinese medicine components are pulverized and then extracted with water to obtain extracts, dried and pulverized again, and the pulverized particle size is controlled at 50-90um to obtain active ingredient raw materials.

(3) Add (2) into (1) and stir evenly to obtain a liniment for treating acne with a disinfection function (with a certain disinfection effect).

(4) Soak the purchased clean facial mask paper in the liniment for 10-15 minutes, take it out and let it dry slightly, and the preparation of the liniment mask is completed.

How to use: Spread the liniment mask prepared above evenly on the face, and after about 20 minutes, rinse it off with clean water.

The tincture mask preparation of embodiment 5 Chinese medicine composition of the present invention

(1) Take each Chinese medicine composition by following weight ratio: peach blossom 20g, wax gourd seed 20g, white clove 20g, mountain arrowhead 20g, polyphylla 20g, salvia miltiorrhiza 40g, angelica dahurica 40g, white moss bark 20g, sulfur powder 10g, Scutellaria baicalensis 15g, gardenia 15g, silver flower 15g, pearl powder 20g, mung bean 20g.

The traditional Chinese medicine components are pulverized and then extracted with 75% ethanol to obtain the extract, dried and pulverized again, and the pulverized particle size is controlled at 50-90um to obtain active ingredient raw materials.

(2) slowly add (1) into 300ml of ethanol (95%), stir evenly, and then the tincture dosage form can be prepared.

(3) Soak the purchased clean mask paper in the liniment for 10-15 minutes, take it out and let it dry slightly, and the preparation of the tincture mask is completed.

Embodiment 6 Chinese medicine extract of the present invention is combined with other drugs or active ingredients to prepare a composite facial mask for treating acne

Weigh each Chinese medicine composition according to the following weight ratio: peach blossom 20g, wax gourd seeds 20g, white clove 20g, Shanzi mushroom 20g, Chonglou 20g, salvia miltiorrhiza 40g, angelica dahurica 40g, white moss bark 20g, sulfur powder 10g, scutellaria baicalensis 15g, Gardenia 15g, silver flower 15g, pearl powder 20g, mung bean 20g.

After pulverizing each traditional Chinese medicine component, water extraction is used to obtain an extract, dried, and pulverized again, and the pulverized particle size is controlled at 50-90um, so that the active ingredient raw material drug can be obtained. Various preparation methods in Examples 2-5 can then be used to prepare various dosage forms, and a certain amount of retinoic acid (accounting for 0.05%-01% of the total amount) is added at the same time, and after mixing evenly, the traditional Chinese medicine composition can be prepared Compound preparation with vitamin A acid, the dosage form includes ointment, emulsion, liniment, tincture, etc.

The beneficial effects of the present invention will be specifically described below through test examples.

Clinical observation of test example 1 facial mask of the present invention treating acne

(1) Criteria for admitted patients (or diagnostic criteria)

Gender and age range of patients: 100 patients, aged 18-35 years, 39 females and 61 males.

Diagnostic criteria: Diagnosis of intractable acne is formulated with reference to the relevant criteria and actual clinical conditions in the "Diagnosis and Curative Effect Criteria for Diseases and Syndromes of Traditional Chinese Medicine" (ZY/T001.8-94) [4] issued by the State Administration of Traditional Chinese Medicine in 1994:

1 At the beginning of the hair follicle, red papules the size of rice grains appear, which can also develop into pustules. Thereafter, induration-like whiteheads or blackheads can be formed, and induration cysts can be formed in severe cases.

2 Mostly occurs on the face, chest and back of puberty men and women, often accompanied by seborrhea.

3 Most of them are induced by improper diet, overeating fat, sweet and delicious food, or exogenous pathogenic factors, and generally have no obvious systemic symptoms.

Symptom characteristics of traditional Chinese medicine (or Western medicine): clinical manifestations are mainly on the face, a skin disease characterized by papules, pustules, and nodules that sometimes squeeze out white broken rice-like powder juice, rash, redness, swelling and pain, or pustules, Or form cysts, local lumps tingling, accompanied by chest tightness and phlegm, dark purple tongue or spots, greasy fur, stringy and astringent pulse.

Diagnosis: acne (phlegm and blood stasis type)

(2) Efficacy evaluation

It was formulated with reference to the relevant standards in Sun Chuanxing's "Clinical Disease Diagnosis Based on Cure and Improvement Standards".

Standard curative effect (%): (number of skin lesions before treatment-number of skin lesions after treatment)/number of skin lesions before treatment×100%.

Clinical recovery: more than 90% of the skin lesions disappeared, and no new skin lesions appeared;

Significantly effective: 60-89% of the skin lesions subside, and basically no new rashes;

Effective: the subjective symptoms are significantly reduced, the skin lesions subside by 30-59%, and no new rash or only a little new rash occurs; it is effective;

Ineffective: less than 30% of the skin lesions subsided, no change or aggravation of symptoms was invalid.

Total effective rate = recovery rate + marked rate + effective rate.

(3) Treatment methods

1. Administration method:

After definite diagnosis, 100 routine patients all adopted: the facial mask prepared by the embodiment 1 of the present invention.

Method of use: (1) Apply the facial mask prepared in Example 1 of the present invention on the face, and rinse it off with clear water after about twenty minutes.

(2) After washing the face, dip a cotton pad with olive oil and apply it on the face for about 5 minutes.

(3) Then cover the face with a hot towel, and do not need to remove the cotton pad at this time.

(4) Wait for the towel to cool down, then remove the towel and cotton pad, and wash your face.

Administration method: 2-3 times a week (the total amount of original medicine used each time is 295g), one month is a course of treatment, and it is used continuously for two months. During the treatment period, no other western medicine and other treatments are provided.

During the treatment period, the diet should be light, avoid fat, sweet and thick food, avoid sweet food, seafood and hot fruits, avoid smoking and alcohol, and ask to eat more vegetables.

2. There is no obvious drug contraindication.

(4) Treatment results

Treatment time: 2 months

Efficacy judgment: the results are as follows

Table 1 Curative effect of 100 patients after 2 months of treatment

treatment result Number of cases (cases) Efficient(%) get well twenty one twenty one markedly effective 30 30 efficient 36 36 invalid 13 13 total 100 87

After two months of treatment, among 100 patients, 21 were cured, 30 were markedly effective, 36 were effective, and 13 were ineffective. The total effective rate reached 87%.

Adverse reactions: No adverse reactions were seen during the medication period. Occasionally, some patients had exacerbated skin rashes at the initial stage of treatment, which were relieved and controlled after adjusting the dosage. Some patients had no abnormality in blood examination, liver and kidney function.

It can be seen from the test results that all acne patients had no adverse reactions and no recurrence. The traditional Chinese medicine composition of the present invention has a significant curative effect on relieving acne, especially intractable acne including suppurative and cystic acne, can improve acne cysts and scars, and effectively treat phlegm-stasis intertwined acne in traditional Chinese medicine. It has a certain effect on the prevention and treatment of acne recurrence and the relief of symptoms after recurrence.

Claims (10)

1. a Chinese medicine composition for the treatment of acne, characterized in that: it is a preparation prepared from crude drugs containing the following weight ratios: 16-22 parts of peach blossom, 15-25 parts of winter melon seeds, 18-23 parts of white clove, 15-25 parts of Shanzi mushroom, 15-25 parts of Chonglou, 40-60 parts of salvia miltiorrhiza, 40-60 parts of Angelica dahurica, white fresh skin 15-25 parts, 8-13 parts of sulfur powder, 10-18 parts of skullcap, 12-18 parts of gardenia, 12-20 parts of silver flower, 15-30 parts of pearl powder, 15-25 parts of mung bean. 2. Chinese medicine composition according to claim 1, is characterized in that: it is the preparation that is prepared from the crude drug of following weight ratio: 16-22 parts of peach blossom, 15-25 parts of winter melon seeds, 18-23 parts of white clove, 15-25 parts of Shanzi mushroom, 15-25 parts of Chonglou, 40-60 parts of salvia miltiorrhiza, 40-60 parts of Angelica dahurica, white fresh skin 15-25 parts, 8-13 parts of sulfur powder, 10-18 parts of skullcap, 12-18 parts of gardenia, 12-20 parts of silver flower, 15-30 parts of pearl powder, 15-25 parts of mung bean. 3. Chinese medicine composition according to claim 2, is characterized in that: it is the preparation that is prepared from the crude drug of following weight ratio: 20 parts of peach blossom, 20 parts of winter melon seeds, 20 parts of white clove, 20 parts of Shanzi mushroom, 20 parts of Chonglou, 40 parts of salvia miltiorrhiza, 40 parts of angelica dahurica, 20 parts of white moss bark, 10 parts of sulfur powder, 15 parts of skullcap, gardenia 15 parts, silver flower 15 parts, pearl powder 20 parts, mung bean 20 parts. 4. The Chinese medicine composition according to any one of claims 1-3, characterized in that: it is composed of peach blossom, wax gourd seeds, white clove, mountain arrow mushroom, Chonglou, salvia miltiorrhiza, angelica dahurica, white fresh skin, sulfur powder It is an external preparation prepared by adding pharmaceutically acceptable excipients or auxiliary ingredients to water or organic solvent extracts of raw medicinal powders of baicalin, baicalin, gardenia, silver flower, pearl powder, and mung bean. 5. The traditional Chinese medicine composition according to claim 4, characterized in that: the dosage form of the external preparation is tincture, ointment, gel, lotion, liniment, emulsion, film. 6. The traditional Chinese medicine composition according to claim 4, characterized in that: the auxiliary component is retinoic acid. 7. The preparation method of the Chinese medicine composition described in any one of claims 1 to 6, characterized in that: a, take the raw material medicine of each weight ratio; b. External preparation prepared by powdering or adding water or organic solvent for extraction, and adding pharmaceutically acceptable excipients or auxiliary ingredients. 8. The preparation method of the Chinese medicine composition according to claim 7, characterized in that: the organic solvent is ethanol. 9. The use of the traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of medicines or cosmetics with the effect of treating acne. 10. The use according to claim 9, characterized in that: the acne is intractable acne, suppurative acne, cystic acne or acne with mixed phlegm and blood stasis.