CN104411320A - Composition comprising natural extracts as active ingredients for improving condition of hair and scalp, and method for preparing same - Google Patents

Abstract

The present invention relates to a composition for improving the condition of hair and scalp containing a natural extract as an active ingredient, a method for preparing the same, and a method for improving the condition of hair and scalp by administering a natural extract. The composition for improving the condition of hair and scalp of the present invention Contains natural extracts as active ingredients, so there is no concern about side effects or toxicity, and it does not require surgery, so it is economical and easy to apply.

Description

Composition for improving hair and scalp condition containing natural extract as active ingredient and preparation method thereof

【Technical field】

The present invention relates to a composition for improving the condition of hair and scalp containing a natural extract as an active ingredient and a preparation method thereof, and to a method for improving the condition of hair and scalp by administering the natural extract of the present invention.

【Background technique】

The most common type of male alopecia as alopecia is the conversion of testosterone (testosterone), one of the androgens, into dihydrotestosterone (DHT, dihydrotestosterone), which is an active androgen, by 5-α reductase (testosterone 5α-reductase) , And the activated dihydrotestosterone combines with the androgen receptor to delay the protein synthesis of the hair follicle cells, thereby shortening the growth period of the hair follicles, and causing the hair follicles to shrink, thus triggering hair loss. Also, in the process of androgenetic alopecia, sebum is also excessively produced, and eventually alopecia with inflammation occurs in the scalp [Dennis A. Holt, et. al, J Med. Chem., 33, 943, (1990)].

The usual hair loss treatment is hair transplantation. That is, it is a method of transplanting a plug (plug) of hair-growing skin from a hair-growing scalp site to a hair loss site. In the case of this method, time is wasted, it is relatively painful, and the cost is high. Other non-drug treatments include ultraviolet radiation and exercise therapy.

Another hair loss treatment method has drug therapy, and U.S. Merck (Merck) sells on the market the hair growth agent that prepares finasteride with oral administration as the effect of inhibiting 5-alpha reductase, to inhibit dihydrotestosterone (DHT) ) of the generated medicine. However, this has the problem of side effects caused by steroids.

Furthermore, it has been reported that equol, which is a major metabolite of daidzein, one of phytoestrogens, directly binds to dihydrotestosterone (DHT) without affecting testosterone. , thereby blocking the process of dihydrotestosterone (DHT) as an androgen.

Therefore, there is a need to develop therapeutic agents derived from natural products that are economical and free from concerns about various side effects and toxicity.

【Content of invention】

[Technical issues to be solved by the invention]

In this regard, in order to solve the above-mentioned problems, the present inventors have confirmed through experiments that reed root, peony root, Fushen, stone reed, marmoset, senna leaf, red sandalwood, grass fruit, Alisma, rhizome, linseed, The fact that the extracts of kudzu flower, turmeric, trichosantheme, hemp seed and sumac are inhibited by 5-alpha reductase to promote the growth of hair, and from the above extracts, the composition for improving the condition of hair and scalp and its A preparation method and a method for improving the condition of hair and scalp.

【Technical solution to the problem】

An object of the present invention is to provide a hair and scalp condition improving composition containing a natural extract as an active ingredient, and a production method thereof.

Furthermore, another object of the present invention is to provide a method for improving the condition of hair and scalp. The method for improving the condition of hair and scalp comprises a method selected from the group consisting of reed root, peony, Fushen, stone reed, marmoset, senna leaf, rosewood, grass The step of administering one or more extracts from the group consisting of fruit, alisma, guanzhong, linseed, kudzu flower, turmeric, melon, hemp seed and sumac to an individual suffering from alopecia.

【Invention effect】

According to the present invention, there are provided a composition for improving hair and scalp condition comprising, as an active ingredient, a natural extract excellent in the effect of inhibiting 5-α reductase (testosterone 5α-reductase), a preparation method thereof, and hair improvement by administering the natural extract And the method of scalp condition. The composition for improving the condition of hair and scalp contains natural extracts as active ingredients, so there is no concern about side effects or toxicity, and since surgery is not required, it is economical and can be easily applied.

【Description of drawings】

Fig. 1 is the extracted ion chromatogram (Extracted-ion chromatograms) of d ₃ -testosterone (d ₃ -testosterone) obtained according to Experimental Example 1 of the present invention (part (a) of Fig. 1: reference standard (Reference standard), Fig. Part (b) of 1: Microsomal fraction).

Fig. 2 is the extracted ion chromatogram (Extracted-ion chromatograms) of the testosterone (testosterone) obtained according to Experimental Example 1 of the present invention (part (a) of Fig. 2: reference standard (Reference standard), part (b) of Fig. 2 : Microsomal fraction (Microsomal fraction).

Figure 3 is the extracted ion chromatograms (Extracted-ionchromatograms) of d ₃ -dihydrotestosterone (d ₃ -DHT, d ₃ -dihydrotestosterone) obtained according to Experimental Example 1 of the present invention (part (a) of Figure 3: reference standard (Reference standard), part (b) of Figure 3: Microsomal fraction).

Fig. 4 is the extracted ion chromatogram (Extracted-ionchromatograms) of the dihydrotestosterone (DHT, dihydrotestosterone) obtained according to Experimental Example 1 of the present invention (part (a) of Fig. 4: reference standard (Reference standard), Fig. 4 ( b) fraction: microsomal fraction (Microsomal fraction).

Fig. 5 shows the degree of hair growth over time obtained according to Experimental Example 4 of the present invention.

【Implementation】

In order to achieve the above-mentioned purpose, a preferred example of the present invention provides a composition for improving hair and scalp condition, the composition for improving hair and scalp condition comprises a composition selected from the group consisting of reed root, peony root, Fushen, stone reed, chestnut marmoset, More than one extract from the group consisting of senna leaf, red sandalwood, grass fruit, alisma, guanzhong, flax seed, kudzu flower, turmeric, melon seeds, hemp seed and sumac is used as an active ingredient.

And, another preferred embodiment of the present invention provides a composition for hair comprising the above-mentioned composition.

And, another preferred example of the present invention provides a method for improving the condition of hair and scalp. The method for improving the condition of hair and scalp includes a method selected from the group consisting of reed root, peony, Fushen, stone reed, marmoset, senna leaf, rosewood, A step of administering one or more extracts from the group consisting of Caoguo, Alisma, Guanzhong, Linseed, Pueraria japonica, Turmeric, Gualou Seed, Hemp Seed and Sappan to an individual suffering from alopecia.

Moreover, another preferred example of the present invention provides a method for preparing the composition for improving the condition of hair and scalp. The method for preparing the composition for improving the condition of hair and scalp includes: using water, ethanol or their mixed solvents to extract In the group consisting of reed root, peony, Fushen, stone reed, marmoset, senna leaf, red sandalwood, grass fruit, Alisma, guanzhong, flax seed, kudzu flower, turmeric, melon seed, hemp seed and sumac more than one step of

a step of subjecting the extract obtained through the above extraction step to filtration under reduced pressure; and

A step of concentrating the filtrate obtained through the above-mentioned filtration step under reduced pressure.

Hereinafter, the present invention will be described in more detail.

5-α-reductase (testosterone 5α-reductase) converts testosterone (testosterone), one of the androgens, into dihydrotestosterone (DHT, dihydrotestosterone) as an active androgen, and the activated dihydrotestosterone interacts with the androgen receptor Combines and delays the protein synthesis of hair follicle cells, thereby shortening the anagen phase of hair follicles, and causing hair follicles to shrink, causing hair loss. Also, during androgenetic alopecia, sebum is excessively produced, and eventually, alopecia with inflammation occurs in the scalp [Dennis A. 15 Holt, et. al, J Med. Chem., 33, 943, (1990)].

Therefore, by inhibiting the above-mentioned 5-α reductase, hair loss can be prevented and hair growth can be promoted, and sebum secretion and dandruff can be prevented or reduced, and scalp inflammation can also be prevented or improved (Olsen EA, Hordinsky M, Whiting D, et al" The importance of dual5alpha-reductase inhibition in 20 the treatment of MPB:results of arandomized placebo-controlled study of dutasteride versus finasteride".J Am Acad Dermatol.55(6),2006,Leyden,James;Dunlap,Frank;Miller,Brace Winters, Peter; Lebwohl, Mark; Hecker, David; Kraus, Stephen; Baldwin, Hilary et al."Finasteride in the treatment of men with frontal male pattern hair loss".Journal of the 25American Academy of Dermatology 40(6 Pt 1): 930–7., 1999).

In order to improve the condition of hair and scalp, the present inventors developed a new form of natural medicine that has no side effects and no toxicity and has an outstanding effect on improving the condition of hair and scalp, which can replace existing drugs that frequently cause unnecessary side effects. As a result, it was confirmed that an extract of a specific medicinal material and a fraction thereof have a remarkable inhibitory effect on 5-alpha reductase (testosterone 5a-reductase), thus completing the present invention.

In this specification, "extract" refers to substances extracted from various organs of various medicinal materials, such as leaves, flowers, stems, fruits, seeds, roots, etc., or whole plants.

Also, in this specification, "improvement" refers to use including prevention or treatment of symptoms, and includes reduction of the range of symptoms, delay or alleviation of symptom progression, alleviation or stabilization of symptoms, partial or complete recovery, other Various beneficial results etc., especially improvement of hair and scalp condition.

More specifically, the above-mentioned improvement of the condition of hair and scalp may preferably be the prevention or treatment (promotion of hair growth) of alopecia, and may be preferably the reduction of sebum secretion, the prevention of dandruff, or the prevention of scalp inflammation.

The hair and scalp condition improving composition according to a preferred example of the present invention contains, as an active ingredient, one or more extracts selected from 16 medicinal materials.

As the above-mentioned medicinal materials, there are reed root, peony, Fushen, Shiwei, shepherd's marmoset, senna leaf, red sandalwood, grass fruit, Alisma, Guanzhong, flaxseed, kudzu flower, turmeric, melon seeds, hemp seeds and sage Wood, the above medicinal materials are described in more detail.

First of all, reed root (Phragmites communis), as the rhizome of reed, is effective against febrile venereal diseases, and is a medicinal material for treating cough caused by lung heat, tuberculosis, lung abscess, vomiting caused by stomach heat, etc. Paeoniae Radix hyperactive digestive tract motility , to promote digestion and absorption, and have analgesic, antispasmodic, sedative effects and inhibitory effects on gastric acid secretion. Various varieties such as white peony, red peony, red peony, grass peony, etc. can be used.

Fushen is the white part of Poria cocos (Poria cocos) that naturally holds pine roots in the middle of Polyporaceae. The leaves and roots of the same plant) have antitussive, expectorant, and antiasthmatic effects, so they are used as medicinal materials. In addition, it exhibits diuretic and antipyretic effects on symptoms such as gonorrhea, urethritis, cystitis, and nephritis, which are urogenital diseases, and it is also used in combination with other drugs for urethral calculi. It is effective for chronic bronchitis, and also has anti-inflammatory and diuretic effects for acute and chronic nephritis and pyelonephritis.

The root of marmoset (Adenophora remotiflora (Siebold&Zucc.) Miq.) has the effects of clearing heat, detoxifying, and reducing phlegm. It is a medicinal material used for detoxification, boil treatment, and expectorant. Laxative effect, antibacterial, antibiotic and curare-like effects.

Pterocarpus santalinus Linne (Pterocarpus santalinus Linne (Leguminosae)) has the effects of cooling blood, hemostasis, detoxification, detumescence, and pain relief, so it can be used for wound bleeding or sore carbuncle swollen poison in oral or external use. (Amomum tsao-ko Crevstet Lemaire) is used to reduce cold air, warm the heart, stop vomiting, and relieve abdominal fullness. At the same time, it has the effect of eliminating phlegm. In addition, it is used for abdominal pain, fullness caused by phlegm, gastric cancer Vomiting, diarrhea, etc.

Alisma canaliculatum is used as a medicinal material in the form of sun-dried roots, absorbs moisture from the body, lowers blood sugar and blood pressure, and thus is not only effective for diabetes, but also removes waste and cholesterol in blood pressure, thereby having the effect of smoothing blood flow. Efficacy, for nephritis, cystitis, urethritis, diabetes, high blood pressure, fatty liver and other symptoms.

Dryopteris crassirhizoma NAKAI is a plant belonging to the family Pteridophyceae, and the rhizome of Dryopteris crassirhizoma NAKAI is known to contain filmaron, phloroglucinol, etc. There are tapeworm remedies, cold remedies, and the like.

Flaxseed as mature seeds of flax (Linum usitatissimum Linne) belonging to the Linaceae family (Linaceae), used in the treatment of diabetes and intestinal diseases, and as a cold infusion for catarrhal diseases of the bronchi, kudzu flower (Pueraria thunberginia) The incompletely bloomed flowers are mainly used for headache, fever, thirst, loss of appetite, abdominal distension and vomiting caused by overeating.

Turmeric (Curcuma longa) is obtained by drying the rhizome of perennial herb belonging to Zingiberaceae. It has the effects of eliminating blood stasis, smoothing ventilation, solving the problem of menstruation after menstruation, and relieving pain.

In addition, Gualou Ren refers to the seeds of Trichosanthes kirilowii Maximowicz or Trichosanthes kirilowii Max.var.japonica Kitamura of Cucurbitaceae, which has the effects of phlegm-heat cough, constipation, boils, and promotion of milk secretion. Especially when it is difficult to spit up due to febrile bronchitis, it protects the lungs, softens the lungs, ventilates and eliminates phlegm, and is effective for polar bronchitis, pleurisy, pneumonia, etc.

Known as the seed of hemp (Cannabis sativa), hemp seed is rich in fat and shiny, so it has the effect of moistening dry matter, helping to gently dredge the intestinal tract, and making blood circulation smooth. Pain, etc. are used as an analgesic.

Sappan (Caesalpinia sappan L.) is a plant belonging to the leguminosae (Leguminosae) and is known as sappan, sappan, red wood, red purple, etc. Sappan does not grow in Korea by itself, but is distributed in Fujian, Guangdong, China Province, Guangxi Province, Guizhou Province, Yunnan Province, Hainan Province, Taiwan, etc. The heartwood of the stem and thick branches of the hematoxylin tree is called hematoxylin, and it is known to have an action on the heart and blood vessels, a central inhibitory action, an antibacterial action, and a hypoglycemic action.

The composition for improving hair and scalp condition according to an example of the present invention contains as an active ingredient one or more extracts of the above-mentioned 16 kinds of medicinal materials having excellent testosterone 5a-reductase inhibitory activity, thereby being able to significantly improve hair and scalp conditions. Hair and scalp condition. Preferably, it may contain extracts of reed root, peony, Fushen, stone reed, hemp seed and sumac.

On the other hand, preferably, the extracts of reed rhizome, peony, Fushen, kudzu flower and sumac in the above-mentioned extracts can be included in powder form, preferably, stone reed, shepherd's marmoset, senna leaf, red sandalwood, grass The extracts of fruit, Alisma, Rhizome, linseed and turmeric can be contained in the form of extract liquid, the extract of Trichosanthes semen can be contained in the form of oil, and the extract of hemp seed can be contained in the form of dilute liquid.

The above hair and scalp condition improving composition may further contain appropriate carriers, excipients, diluents, etc. according to methods commonly used in various fields, thereby being suitable as a pharmaceutical composition, a functional food composition, or a hair composition. .

In the case of providing a pharmaceutical composition, the above-mentioned composition can be administered orally or parenterally according to a usual method, for example, when administered orally, it can be in the form of powder, granule, tablet, suspension , latex, syrup and other dosage forms.

The preferred dosage can be a content suitable for the treatment or prevention of the subject and/or disease, which can be based on the subject's age, sex, general health status and body weight, the type and severity of the disease, the type of dosage form, The type and content of other components contained in the composition, the secretion rate of the composition, the route and period of administration, etc. can be adjusted according to various factors, and can be appropriately selected by those skilled in the art to which the present invention pertains. Mammals including humans can be used as the subject of administration.

When the above-mentioned composition is provided in the form of a hair composition, based on the weight of the entire hair composition, preferably, it may contain 0.0001 to 99.9% by weight of the composition for improving the condition of hair and scalp, and more preferably, it may contain 0.1 ~50% by weight of the above hair and scalp condition improving composition, preferably, can be selected from shampoo, conditioner, hair cream, hair gel, hair mousse, hair styling cream, shampoo soap, shampoo, Dosage forms in the group consisting of conditioner, hair mask, and hair balm are offered.

As yet another preferred example of the present invention, there is provided a method for improving hair and scalp conditions, the method for improving hair and scalp conditions comprising at least one of the above-mentioned 16 kinds of medicinal materials with outstanding 5-α reductase (testosterone 5a-reductase) inhibitory activity A step of administering an extract of the method to an individual suffering from alopecia.

The above-mentioned "administration" step can be implemented in an oral or non-oral manner. When administering in a non-oral manner, external application to the skin, subcutaneous injection, transdermal administration, and local administration can be selected, but it is not limited here. Preferably, for external use on the skin, a method of applying to the skin is available.

In the case of topical administration, semisolid preparations such as ointments, creams, or gels can be used for administration, and in the case of transdermal administration, in addition to matrix patches or reservoir patches (reservoir patch) , semi-solid products (hydroalcoholic gels, etc.) can also be utilized, but are not limited thereto.

According to another preferred example of the present invention, there is provided a method for producing the aforementioned hair and scalp condition improving composition.

Preferably, the above preparation method includes: using water, ethanol or their mixed solvents to extract the selected from reed root, peony, Fushen, Shiwei, marmoset, Senna leaf, red sandalwood, Tsaoguo, Alisma, Guanzhong, More than one step in the group consisting of linseed, kudzu flower, turmeric, melon seeds, hemp seed and sumac; the step of decompression filtering the extract obtained through the above extraction step; and the step of filtering the extract obtained through the above filtration step The obtained filtrate was subjected to a step of concentrating under reduced pressure.

In order to further improve the extraction effect, preferably, each of the above-mentioned medicinal materials can be crushed before the extraction step. In particular, among the above-mentioned medicinal materials, those that have the form of fruits or seeds, for example, can be crushed after being cut with scissors and other tools. to use. The pulverization method is not particularly limited, for example, various tools such as a stirrer can be used.

Preferably, the above-mentioned extraction step can be realized by extracting each medicinal material individually or by mixing all the medicinal materials to extract in a mixture state. When each medicinal material is extracted and used separately, the extraction solvents may be the same or different.

And, preferably, the above-mentioned extraction step can be realized by leaching after mixing each medicinal material or their mixture with an extraction solvent.

Preferably, the above-mentioned leaching can be realized at a temperature range of 30 to 40°C, more preferably at a temperature of 33 to 38°C, preferably for 1 to 3 days, more preferably for 45 to 45°C 50 hours.

The extraction solvent is not particularly limited, but preferably, water, ethanol or their mixed solvents can be used for extraction, more preferably, ethanol can be used, most preferably, 60 to 80% (v/v) ethanol can be used .

And, preferably, 400ml to 800ml of the above-mentioned extraction solvent may be used per 100g of the medicinal material.

The above-mentioned vacuum filtration step is not particularly limited, and can be achieved by methods known in the art.

Preferably, the filtrate obtained through the above filtration step can be further subjected to a step of concentrating under reduced pressure. The above step of concentrating under reduced pressure is not particularly limited, and can be realized by methods known in the art. After the above steps, a freeze-drying step can also be optionally included.

Hereinafter, the present invention will be described in detail through examples. However, the following examples are only for illustrating the present invention, and the present invention is not limited to the following examples.

【Example】

[Example 1: Preparation of extract]

Prepare reed root, peony, Fushen, stone reed, marmoset, senna leaf, red sandalwood, grass fruit, Alisma, guanzhong, flax seed, kudzu flower, turmeric, melon seed, hemp seed and sumac respectively smashed. The crushing is carried out after cutting the fruit or seeds with scissors.

After adding and mixing 100 g of the pulverized medicinal materials and 600 ml of 70% (v/v) ethanol (EtOH) in a 1000 ml bottle (Duran), it was leached in a constant temperature water tank at a temperature of 35° C. for 48 hours.

Utilize filter paper (Watman (Watman) (Watman) No. 21 filter) to carry out after decompression filtration of the extract that obtains, utilize decompression concentrator to concentrate the filtrate that reclaims, thereby obtained the crude drug extract of following table 1 ( Depending on the crude drug, it is recovered in the form of extract, powder, or dilute liquid). After dispensing the prepared extract into a 50 ml tube, it was sealed with parafilm (Parafilm), and it was stored in refrigeration.

【Table 1】

crude drug name Amount obtained (g) Yield (%) Recovery form reed root 0.22 0.22 powder peony 2.43 2.43 powder Fushen 0.26 0.26 powder stone reed 0.93 0.93 extract Herba marmoset 0.16 0.16 extract Sennaye 1.24 1.24 extract Rosewood 1.21 1.21 extract Tsaoko 1.32 1.32 extract Alisma 0.93 0.93 extract Guan Zhong 1 1 extract flaxseed 0.52 0.52 extract kudzu flower 3.65 3.65 powder turmeric 15 15 extract Gualou Ren 1.86 1.86 Oil sumac 2.78 2.78 powder Maren 8.83 8.83 thin liquid

[Experimental example 1: Quantitative analysis of testosterone and dihydrotestosterone by GC-MS]

The chromatograms used for the quantitative analysis of testosterone and dihydrotestosterone (DHT) in the liver microsomal fraction extracted after the reaction are shown in FIGS. 1 to 4 .

[Experimental Example 2: Evaluation and Determination of 5-α Reductase Inhibition Efficacy]

In order to evaluate the 5-alpha reductase inhibitory effect of the extract obtained in Example 1 above, first, the microsomal fraction (Microsomal fraction) extraction conditions were established using finasteride (Mertk) as a control drug.

Specifically, using a homogenizer (Homogenizer), a tissue homogenization kit (tissuehomogenize kit), and a tissue grinder (TissueLyzer) to fractionate the above-mentioned finasteride to obtain fractions, and use this as an object to carry out The experiments were compared to obtain the results in Table 2 below.

【Table 2】

As shown in Table 2 above, in the three conditions used to extract microsomal fractions, the efficacy of 5-α reductase was confirmed, but in the case of using a tissue grinder, the efficacy of 5-α reductase was relatively low It can be seen that the activity of 5-α reductase is inhibited.

The experiment was repeated twice on the homogenizer-based fraction, and the reproducibility of the evaluation of the 5-α reductase inhibitory efficacy was confirmed, as shown in Table 3 below.

【table 3】

[Experimental Example 3: Evaluation of the efficacy of natural extracts in inhibiting 5-α reductase]

In order to evaluate the efficacy of the natural extracts obtained in Example 1 above in inhibiting 5-alpha reductase, each natural extract and testosterone were dissolved in dimethyl sulfoxide (DMSO, dimethyl sulfoxide) and methanol (MeOH) respectively. used in .

First, in order to understand the influence of the two organic solvents, a 100 μg/mL testosterone solution was diluted in dimethyl sulfoxide and methanol at a concentration of 10 μg/mL for a comparative experiment, and the results obtained are shown in the following Table 4 middle.

【Table 4】

As shown in Table 4 above, the efficacy of 5-α reductase was confirmed in both solvents in which testosterone was diluted, and it was confirmed that there was no influence of the organic solvent from the point of view of similar result values.

Utilize the effect analysis method of the 5-alpha reductase of establishment, use 16 kinds of natural extracts obtained according to the above-mentioned Example 1 and the longan meat extract obtained by extracting in the same way as the above-mentioned Example 1 as a control group, and the red bean extract 5-alpha reductase inhibitory effect experiment was repeated twice, and the results thus obtained are shown in Table 5 below.

【table 5】

As shown in the above table 5, the 16 kinds of extracts of medicinal materials obtained according to Example 1 of the present invention do not exhibit the effect of 5-alpha reductase at all, so that it can be confirmed that the effect of inhibiting 5-alpha reductase is outstanding, on the contrary, in the control group In the longan meat extract, the red bean extract, and the Jujube seed extract, it was confirmed that there was no 5-α reductase inhibitory effect regardless of the concentration used. In particular, it can be seen that all 16 kinds of natural extracts of the present invention have the same effect on inhibiting 5-α reductase as the conventional known positive control (positive control), that is, Sophora flavescens.

[Experimental example 4: Determination of mouse hair growth promoting effect using the composition of the present invention]

In order to understand the effect of the composition for hair loss prevention and hair growth promotion of the present invention, the hair growth promotion effect of the composition was confirmed using C57BL/6N mice. The above-mentioned composition for preventing hair loss and promoting hair growth uses hemp seed extract and sumac extract. After completely removing the hair of C57BL/6N mice at 7 weeks after birth in the second catagen, 150 μl each of the composition of the present invention and the control substance were applied to every 10 mice once a day. , applied continuously for 5 weeks. The degree of hair growth promotion over time was compared with the naked eye, and a conclusion was drawn ( FIG. 5 ). As a negative control group, 80% ethanol having no hair growth promoting effect was used, and as a positive control group, 3% minoxidil was used. Table 6 below is a table comparing and analyzing the degree of hair growth over time by visual observation.

【Table 6】

In the above Table 6, "-" means that the hair hardly grows, and "+" means that the hair grows with the lapse of time, and the more the number of "+" is, the greater the amount of hair growth is. It is known that hair grows in hemp seed extract and hematoxylin extract, which means that the composition of the present invention promotes hair growth.

[Experimental Example 5: Determination of Germinal Area]

For the hair growth measurement photos obtained in Experimental Example 4 above, i-Solution Lite, which is an image analysis program, was used to measure the ratio of the hair removal area to the hair growth area. First, after measuring the entire area of hair removal and measuring the area of hair growth, the hair growth rate was measured as a percentage (%) relative to the entire area. The shaved area and the growth rate of hair are shown in Table 7 below with the lapse of time.

【Table 7】

In the order of the positive control group (3% minoxidil), HD-23 (seed seed extract), a high hair growth rate was exhibited, and in the case of HD-124 (sumacin extract), after 5 weeks, it was possible to A significant increase in hair growth rate was confirmed.

Claims (9)

1. A composition for improving the condition of hair and scalp, characterized in that, it comprises a composition selected from the group consisting of reed root, herbaceous peony, Fushen, stone reed, marmoset, senna leaf, red sandalwood, grass fruit, Alisma, rhizome, flax One or more extracts from the group consisting of Jen, Pueraria japonica, turmeric, Trichosanthes semen, Hemp seed and Sappan wood are used as active ingredients. 2. The composition for improving the condition of hair and scalp according to claim 1, characterized in that the composition for improving the condition of hair and scalp contains reed root extract, peony extract, Fushen extract, and stone reed extract , hemp seed extract and sumac extract. 3. The composition for improving the condition of hair and scalp according to claim 1, wherein the composition for improving condition of hair and scalp is used for preventing or treating alopecia. 4. The hair and scalp condition improving composition according to claim 1, wherein the hair and scalp condition improving composition is used for reducing sebum secretion, preventing dandruff, or preventing scalp inflammation. 5. A hair composition characterized by comprising the hair and scalp condition improving composition according to any one of claims 1 to 4. 6. The composition for hair according to claim 5, characterized in that, the composition for hair is selected from the group consisting of toner, conditioner, hair milk, hair spray, hair mousse, hair styling cream, shampoo , Shampoo, Conditioner, Hair Mask, and Baking Ointment are available in formulations. 7. A method for preparing the hair and scalp condition improving composition according to any one of claims 1 to 4, comprising: Use water, ethanol or their mixed solvents to extract selected from reed root, peony, Fushen, stone reed, marmoset, senna leaf, red sandalwood, grass fruit, Alisma, guanzhong, linseed, kudzu flower, turmeric, More than one step in the group consisting of Trichosanthes semen, Hemp seed and Sappan; a step of subjecting the extract obtained through the above extraction step to filtration under reduced pressure; and A step of concentrating the filtrate obtained through the above-mentioned filtration step under reduced pressure. 8. The preparation method of the composition for improving hair and scalp condition according to claim 7, characterized in that, in the above-mentioned extraction step, reed root, peony, Fushen, stone reed, Hemp seed and hematoxylin are mixed with ethanol to extract. 9. The method for preparing the hair and scalp condition improving composition according to claim 8, characterized in that the extraction is carried out at a temperature of 30 to 40°C for 1 to 3 days.