CN103751245B - One treats dermopathic Chinese medicine composition and uses thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating skin diseases and its application. It is made of the following raw materials in parts by weight: 20-40 parts of wormwood, 40-60 parts of geranium, 40-60 parts of saxifrage, The medicament of the traditional Chinese medicine composition can be lotion, tincture, oil, emulsion, ointment, plaster or gel. The traditional Chinese medicine composition has remarkable curative effect in treating skin diseases, especially eczema, neurodermatitis and skin ulcer, and has a high cure rate. At the same time, the traditional Chinese medicine composition has few medicinal flavors, is easy to prepare, low in cost, and is administered through the skin with little toxic and side effects. High safety, easy to be accepted by patients.

Description

A kind of traditional Chinese medicine composition for treating skin diseases and its application

【Technical field】

The invention relates to a traditional Chinese medicine composition for treating skin diseases and its application, in particular, it is a Chinese patent medicine prepared from Chinese herbal medicines.

【Background technique】

Eczema is a skin inflammatory reaction with severe itching caused by various internal and external factors. Divided into acute, subacute and chronic stages. In the acute phase, it tends to exudate, while in the chronic phase, it is infiltrating and hypertrophic. Generally, the skin lesions of eczema are pleomorphic, mainly erythema, papule, and papuular herpes. The rash is obvious in the center and gradually spreads to the surroundings. The boundary is unclear, diffuse, and has a tendency to exudate.

Neurodermatitis, also known as lichen simplex chronicus, is a chronic inflammatory disease characterized by skin lichenification and severe itching. It is generally believed that the occurrence of this disease may be caused by cerebral cortex inhibition and excitatory dysfunction. Anxiety, depression, local stimuli (such as friction, sunburn, sweating) and indigestion, drinking, eating spicy food, etc. can induce or aggravate the disease.

Skin ulcer is a common and frequently-occurring disease in traditional Chinese medicine surgery, with skin ulcer as the main clinical manifestation and long-term non-healing as the clinical feature. Those who have not recovered for a long time. Because the sore surface is difficult to heal and consumes a lot, it causes great psychological pressure and economic loss to the patient, and seriously affects the patient's health and quality of life.

At present, there are many types of traditional Chinese medicines used to treat the above skin diseases. For example, Chinese patent document CN201310358800.6, published on November 13, 2013, discloses a compound traditional Chinese medicine external preparation for treating dermatitis and eczema, which is characterized by the following weight percentage It is prepared from raw materials and a pharmaceutically acceptable carrier: 3-15 parts of snake oil, 3-12 parts of comfrey and 10-45 parts of Sijiqing. Its dosage form is cream, emulsion, liniment, liposome or spray. The invention is applied to the clinical treatment of dermatitis and eczema diseases, and has the functions of anti-inflammation, anti-allergy, antibacterial, moisturizing, etc., and the effect is remarkable. Chinese patent document CN201110338788.3, published on 2013.05.08, discloses a traditional Chinese medicine preparation for treating skin ulcers. 1-3 parts of pulsatilla, 1-3 parts of purslane, 2-4 parts of Xuanming powder, 1-3 parts of hibiscus bark, and 0.5-2 parts of safflower. The traditional Chinese medicine preparation can be made into tablets, mixtures, granules and capsules. External use has the effects of clearing away heat and dampness, cooling blood and detoxification, reducing swelling and relieving pain. Skin wounds such as sexual ulcers and infectious ulcers are characterized by local redness, swelling and exudation as the main symptom. It is still very necessary to research and develop more traditional Chinese medicine compositions that can widely treat various skin diseases, have few components, and have low cost.

【Content of invention】

The object of the present invention is to provide a traditional Chinese medicine composition for treating skin diseases in view of the deficiencies in the prior art.

Another object of the present invention is to provide a preparation method of the above-mentioned traditional Chinese medicine composition.

Another object of the present invention is to provide the application of the above-mentioned traditional Chinese medicine composition.

For realizing above-mentioned object, the technical scheme that the present invention takes is:

A traditional Chinese medicine composition for treating skin diseases is prepared from the following raw materials in parts by weight: 20-40 parts of wormwood, 40-60 parts of geranium, and 40-60 parts of saxifrage.

Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of wormwood, 45-55 parts of geranium, and 45-55 parts of saxifrage.

More preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of wormwood, 50 parts of geranium, and 50 parts of saxifrage.

The medicament of the traditional Chinese medicine composition is lotion, tincture, oil, emulsion, ointment, plaster or gel.

Preferably, the agent of the traditional Chinese medicine composition is an oil agent.

Preferably, the vegetable oil used as an auxiliary material in the oil agent is olive oil.

For realizing above-mentioned second purpose, the technical scheme that the present invention takes is:

A preparation method of the above-mentioned traditional Chinese medicine composition, comprising the following steps: weighing 20-40 parts of wormwood, 40-60 parts of geranium, and 40-60 parts of saxifrage by weight, and adding 600-1200 parts Olive oil, soak for 24-72 hours, then decoct on low heat until the raw material is burnt black, cool naturally and filter to get the oil.

For realizing above-mentioned 3rd purpose, the technical scheme that the present invention takes is:

Use of the traditional Chinese medicine composition as described above in the preparation of medicines for treating skin diseases.

The skin disease is eczema, neurodermatitis or skin ulcer.

The present invention has the advantage that:

1. It is effective in treating skin diseases, especially eczema, neurodermatitis and skin ulcers, with a high cure rate;

2. Fewer medicinal flavors, only three flavors, simple preparation and low cost;

3. Drug administration through the skin has less toxic and side effects, high safety, and is easy to be accepted by patients.

【detailed description】

The specific implementation manners provided by the present invention will be described in detail below.

Embodiment 1 Preparation of Chinese medicine composition of the present invention (1)

Weigh 30 parts of wormwood, 50 parts of geranium, and 50 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then simmer on low heat for about 7 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 2 Preparation of Chinese medicine composition of the present invention (two)

Weigh 20 parts of wormwood, 60 parts of geranium, and 40 parts of saxifrage by weight, add 1200 parts of olive oil, soak for 24 hours, then simmer on low heat for about 8 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 3 Preparation of Chinese medicine composition of the present invention (three)

Weigh 40 parts of wormwood, 40 parts of geranium, and 60 parts of saxifrage by weight, add 600 parts of olive oil, soak for 72 hours, then simmer on low heat for about 6 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 4 Preparation of Chinese medicine composition of the present invention (four)

Weigh 20 parts of wormwood, 40 parts of geranium, and 60 parts of saxifrage by weight, add 1200 parts of olive oil, soak for 72 hours, then simmer on low heat for about 6 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 5 Preparation of Chinese medicine composition of the present invention (five)

Weigh 25 parts of wormwood, 55 parts of geranium, and 45 parts of saxifrage by weight, add 600 parts of olive oil, soak for 72 hours, then decoct on low heat for about 8 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 6 Preparation of Chinese medicine composition of the present invention (6)

Weigh 35 parts of wormwood, 45 parts of geranium, and 55 parts of saxifrage by weight, add 800 parts of olive oil, soak for 60 hours, then simmer for about 6 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 7 Preparation of Chinese medicine composition of the present invention (7)

Weigh 40 parts of wormwood, 60 parts of geranium, and 60 parts of saxifrage by weight, add 1000 parts of olive oil, soak for 36 hours, then decoct on low heat for about 8 hours until the raw material is charred, cool naturally, filter and take the oil .

Embodiment 8 Preparation of Chinese medicine composition of the present invention (eight)

Weigh 40 parts of wormwood, 40 parts of geranium, and 60 parts of saxifrage by weight, add 1000 parts of olive oil, soak for 36 hours, then simmer on low heat for about 6 hours until the raw material is charred, cool naturally, filter and take the oil .

The preparation of embodiment 9 Chinese medicine composition lotion of the present invention

Take wormwood, geranium, and saxifrage according to any one of claims 1-8 by weight, add 8-12 times the amount of water, decoct for 3-4 hours, filter out the concoction, and add 5- 6 times the amount of water, decoct for 2-3 hours, filter out the medicinal juice, and combine the second decoction.

The preparation of embodiment 10 Chinese medicine composition tincture of the present invention

Take wormwood, geranium, and saxifrage according to any one of claims 1-8 by weight, add 8-12 times the amount of water, decoct for 3-4 hours, filter out the concoction, and add 5- 6 times the amount of water, decoct for 2-3 hours, filter out the medicinal juice, combine the second decoction, let it stand, filter the supernatant, concentrate, let it cool, add 2.5 times the amount of alcohol to the concentrated solution, stir and precipitate overnight. Take the supernatant, concentrate to a thick extract, add an appropriate amount of ethanol with a specified concentration of 60%, dissolve or dilute, and let stand to obtain.

The preparation of embodiment 11 Chinese medicine composition emulsion of the present invention

Take wormwood, geranium, and saxifrage according to any one of claims 1-8 by weight, add 8-12 times the amount of water, decoct for 3-4 hours, filter out the concoction, and add 5- 6 times the amount of water, decoct for 2-3 hours, filter out the medicinal juice, combine the second decoction, let it stand, filter the supernatant, concentrate, let it cool, add 2.5 times the amount of alcohol to the concentrated solution, stir and precipitate overnight. Take the supernatant and concentrate to a thick extract. Take soybean oil, add gum arabic powder and grind evenly, add distilled water according to the ratio of oil: water: gum 4:2:1, grind until colostrum. Mix the thick extract with colostrum and stir well.

The preparation of embodiment 12 Chinese medicine composition ointment of the present invention

Take wormwood, geranium, and saxifrage according to any one of claims 1-8 by weight, add 8-12 times the amount of water, decoct for 3-4 hours, filter out the concoction, and add 5- 6 times the amount of water, decoct for 2-3 hours, filter out the medicinal juice, combine the second decoction, let it stand, filter the supernatant, add appropriate amount of beeswax and yellow vaseline, and decoct at a slow fire (about 100°C) for 15-30min , cooled to a paste that is.

The preparation of embodiment 13 Chinese medicine composition plaster of the present invention

Take by weighing wormwood, geranium, saxifrage according to the arbitrary described weight portion of claim 1-8, break into pieces. Put vegetable oil (such as rapeseed oil, peanut oil, etc.) in a pot, put the above-mentioned ingredients into the pot after slightly heating, heat and stir constantly, until the ingredients are fried until the surface is dark brown and the inside is brown. After frying, remove the dregs with iron wire, and the oil after removing the dregs is medicinal oil. Take the medicated oil and continue refining until dripping into beads. After refining, remove the dan from the fire, generally add 250g dan to 500g oil, dry the yellow dan first and pass through a 100-mesh sieve, add a small amount of dan, and stir until it becomes a viscous paste. After the "fire poison" is removed by spraying water, take a certain amount of plaster with a bamboo stick and put it on kraft paper or plaster cloth. Musk and volatile borneol, camphor, mint, etc. can be sprinkled on at last.

Embodiment 14 Preparation of Chinese medicine composition gel of the present invention

Take by weighing wormwood, geranium, saxifrage according to the arbitrary described weight portion of claim 1-8, break into pieces. Put a small amount of vegetable oil (such as rapeseed oil, peanut oil, etc.) in a pot, put the above medicinal materials into the pot after slightly heating, heat and decoct with constant stirring, and take the filtrate. Add carbomer to glycerin and grind it to make it moist, then add a small amount of distilled water to grind it, then move it to a measuring cup, take another appropriate amount of triethanolamine, ethylparaben, and distilled water to dissolve, stir it into a gel, add an appropriate amount of distilled water and mix well , add the above-mentioned medicinal material filtrate, and grind until uniform.

Embodiment 15 Clinical trials of Chinese medicine composition of the present invention treating eczema

1. Select a case

A total of 120 patients were selected from the dermatology clinic. All patients met the diagnostic criteria of eczema and met the characteristics of the symmetry of the main skin lesions. Among them, there were 52 males and 68 females. The youngest was 18 years old, the oldest was 60 years old, and the average age was (38.02±16.37) years old. The shortest course was 1 week, the longest course was 3 years, and the average course was (9.25±13.08) months. The distribution of skin lesions of the research objects: the proportions of the head and face, upper limbs, trunk and lower limbs were 23.58%, 50.39%, 45.61%, and 41.71%, respectively.

2. Treatment method

(1) Treatment group: wash the affected part with warm water, wipe it dry, take the Chinese medicine composition oil preparation prepared in Example 1, evenly smear the affected part of the skin with a cotton swab, and give it according to the dosage of about 2g crude drug crude drug/ ^cm2 of the skin lesion. Medicine, once in the morning and once in the evening, and the course of treatment is 14 days. The patient will return to the clinic on the 14th day after treatment, and no internal medicine is needed during the treatment.

(2) Control group 1: Weigh 55 parts of wormwood and 75 parts of geranium by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the crude drug is burnt black, filter and take after natural cooling oil, get this group of Chinese medicine oil for treatment. The administration method and course of treatment were the same as those of the treatment group.

(3) Control group 2: Take 55 parts of wormwood and 75 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material medicine is scorched black, filter and take after natural cooling oil, get this group of Chinese medicine oil for treatment. The administration method and course of treatment were the same as those of the treatment group.

(4) Control group 3: Weigh 65 parts of geranium and 65 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material is burnt black, and filter after natural cooling Get the oil to get this group of Chinese medicinal oils for treatment. The administration method and course of treatment were the same as those of the treatment group.

3. Curative effect observation and evaluation indicators

The eczema area and severity index (EASI) was scored before and after treatment.

3.1 Eczema Area and Severity Index (EASI)

According to Table 1 and Table 2, the skin lesion area and severity of the patient's head and neck, trunk, upper limbs, and lower limbs were scored respectively, and the EASI value of each part was calculated. Finally, the total EASI score = A+B +C+D Calculate the total EASI value of the treatment group, control group 1-control group 3.

Table 1 EASI scoring table (over 8 years old)

Note: E is erythema, I is edema or papule, Ex is exfoliation, L is lichenification.

Table 2 EASI Scoring Rules

3.2 Overall curative effect evaluation

The curative effect indicators were the change value of EASI score before and after treatment and the improvement rate of EASI score before and after treatment. The change value and improvement rate of EASI score before and after treatment in each group were defined as: EASI score change value = EASI score before treatment - EASI score after treatment; EASI score improvement rate = (EASI score before treatment - EASI score after treatment) / EASI score before treatment Score × 100%.

According to the degree of clinical improvement before and after treatment, the main curative effect index is calculated, and the total curative effect evaluation at the end of the treatment is carried out according to the 4 grades of recovery, marked effect, progress, and ineffectiveness. The recovery rate of EASI score was >90%, and the itching disappeared. Significantly, the improvement rate of EASI score is 60%-89%, and the itching is obviously relieved. The improvement rate of progressive EASI score is 20%-59%, and itching is relieved. Ineffective EASI score improvement rate < 20%, pruritus same as before treatment or aggravated. The cured cases and markedly effective cases were combined as effective cases to calculate the effective rate.

4. Statistical methods

SPSS 18.0 statistical software was used for statistical processing, measurement data were expressed as mean ± standard deviation (mean ± sd), t test was used, and ^χ2 test was used for count data.

5. Treatment results

4.1 Changes of EASI value in each group before and after treatment

The changes of EASI values before and after treatment in each group are shown in Table 3. There was no significant difference in the average EASI value between the treatment group and the control group before treatment (P>0.05), and they were comparable. After 14 days of treatment, the average EASI value of each group decreased compared with that before treatment, and the post-treatment scores of the treatment group were significantly different from those of the control group 1-control group 3 after treatment (P<0.05) .

Table 3 Comparison of EASI scores in each group

4.2 Comparison of curative effect and effective rate after treatment in each group

The curative effect and effective rate results of each group after treatment are shown in Table 4. After 14 days of treatment, the effective rate of the treatment group was significantly different from that of the control group 1-control group 3 (P<0.05), and there was no significant difference in the effective rate between the control group 1-control group 3 (P >0.05).

Table 4 Comparison of curative effect and effective rate after treatment in each group

Clinical trial of embodiment 16 Chinese medicine composition of the present invention treating neurodermatitis

1. General Information

Clinically collected 120 patients, aged 18-70 years, with an average age of 36 years, and the course of disease ranged from 3 months to 8 years, with an average of 4.3 years.

2. Diagnostic criteria

The diagnosis is based on the "Standards for the Diagnosis and Curative Effect of Diseases and Syndromes of Traditional Chinese Medicine" issued by the State Administration of Traditional Chinese Medicine:

(1) Occur in the neck, lumbosacral, elbow and other parts, with significant itching;

(2) The rash merges into sheets, the skin is thickened and rough, the skin grooves are deepened, the skin ridges are raised, and there are lichenification and pigmentation;

(3) Chronic course of disease, exudation tendency.

3. Exclusion criteria

Chronic eczema, primary cutaneous amyloidosis, atopic dermatitis, lichen planus, cancer itch, antihistamines and sugar and hormone hormones stopped 1 week before treatment, other organ diseases, pregnant women and lactating period Patients are excluded.

4. Treatment method

(1) Treatment group: wash the affected part with warm water, dry it lightly, take the Chinese medicine composition oil preparation prepared in Example 1, evenly smear the affected part of the skin with a cotton swab, and give it according to the dosage of about 2g crude drug crude drug/ ^cm2 of the skin lesion. Medicine, once in the morning and evening, 10 days as a course of treatment, follow-up consultation after 6 courses of treatment, no internal medicine is needed during the treatment.

(2) Control group 1: Weigh 55 parts of wormwood and 75 parts of geranium by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the crude drug is burnt black, filter and take after natural cooling Oil, Chinese medicine oil for treatment. The administration method and course of treatment were the same as those of the treatment group.

(3) Control group 2: Take 55 parts of wormwood and 75 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material medicine is scorched black, filter and take after natural cooling Oil, Chinese medicine oil for treatment. The administration method and course of treatment were the same as those of the treatment group.

(4) Control group 3: Weigh 65 parts of geranium and 65 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material is burnt black, and filter after natural cooling Get the oil to get the Chinese medicine oil for treatment. The administration method and course of treatment were the same as those of the treatment group.

5. Scoring criteria

The degree of pain and itching, the number and size (minimum diameter) of moss-like changes, the degree of hypertrophy, and pigmentation of patients before and after treatment were scored using a 0-3 scale standard score. 0: No itching, smooth skin, pigmented skin; 1: Occasional itching, no irritability, skin lesion diameter <0.5cm, 1-6 skin lesions, mild mossy change, light red pigment; 2 points Moderate itching, but tolerable, lesions 1.5-2.5 cm in diameter, 7-12 lesions, moderate mossy change, brown pigment; 3 points, severe itching, intolerable, lesions > 2.5 cm in diameter cm, with more than 12 skin lesions, the skin is thick and rough, mossy and dark brown. The above 5 scores are added together for the total score. Integral decrease index=[(total integral before treatment-total integral after treatment)/total integral before treatment]×100%.

According to the "Diagnosis and Curative Effect Standards of Traditional Chinese Medicine Diseases and Syndromes": cured, the integral decline index is ≥90%; markedly effective, the integral decline index is 60%-89%; effective, the integral decline index is 20%-59%; invalid, the integral decline index is ≤ 90%. The cured cases, markedly effective cases and effective cases were summed up to calculate the effective rate.

6. Treatment results

The curative effect and effective rate results of each group after treatment are shown in Table 5. After 6 courses of treatment, the effective rate of the treatment group was significantly different from that of the control group 1-control group 3 (P<0.05).

Table 5 Comparison of curative effect and effective rate after treatment in each group

Embodiment 17 The clinical trial of Chinese medicine composition of the present invention treating skin ulcer

1. General Information

Inclusion criteria: Those with skin ulcers that have not healed for more than 1 month and those with Damp-Heat Syndrome in the TCM Syndrome Diagnostic Criteria. Patients aged 18-75, regardless of gender.

2. Diagnostic criteria

(1) Diagnostic criteria of Western medicine: skin ulcers that have not healed for more than 1 month.

(2) Diagnostic criteria of TCM syndromes: For those with damp-heat syndrome, refer to "National Standards of the People's Republic of China·Terms of Clinical Diagnosis and Treatment of Traditional Chinese Medicine·Syndrome", "Standards of the People's Republic of China Traditional Chinese Medicine Industry Standards for the Diagnosis and Efficacy of TCM Disease Syndromes" and the National Standards Compiled the textbook "Surgical Medicine of Traditional Chinese Medicine" (a new century national textbook for higher Chinese medicine colleges).

Main symptoms: The wound surface is rotten and dark, soaked in pus, foul smell, redness, swelling and burning around, and sometimes itching.

Secondary symptoms: aversion to cold and fever, thirst, constipation, red urination; red tongue or greasy coating, slippery and rapid pulse.

The diagnosis can be made if there are two main symptoms and two secondary symptoms of the above-mentioned damp-heat syndrome.

3. Inclusion criteria

Meet the diagnostic criteria of Western medicine and TCM syndromes of this disease; skin ulcer wound area ≥ 2cm ² ; age ≥ 18 years old and ≤ 75 years old, male or female, informed consent, sign the informed consent form, and voluntarily undergo the test.

4. Discharge standard

Those who do not meet the diagnostic criteria and inclusion criteria; or those who meet the diagnostic criteria and inclusion criteria, but have one of the following conditions: combined with severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic systems, mental illness, tumors or AIDS patients; pregnant or breastfeeding women, those with allergic constitution; those with severe infection and critical condition; those with diabetes and unstable blood sugar control; those with neurotrophic disorders; Radiation ulcers, decubitus ulcers, leprosy ulcers, syphilitic ulcers; ulcers with exposed tendons and bones; those who meet the inclusion criteria, but do not use the prescribed medication, cannot judge the curative effect, or have incomplete data.

5. Treatment

(1) treatment group: adopt the Chinese medicine composition oil preparation prepared by embodiment 1, evenly smear the affected part of the skin lesion with a cotton swab, according to about 2g crude drug crude drug/cm ² dosage administration of the skin lesion, sooner or later each once, treat for 4 weeks 1 course of treatment, after 3 courses of treatment, the effect will be judged, and no internal medicine is needed during the treatment.

(2) Control group 1: Weigh 130 parts of wormwood by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material is burnt black, filter and take the oil after natural cooling, and evenly smear it with a cotton swab For the affected part of the skin lesion, the dosage of about 2g raw drug crude drug/cm ² skin lesion is administered, once in the morning and once in the evening, 4 weeks of treatment is a course of treatment, and the effect will be judged after 3 courses of treatment. During the treatment period, no internal medicine is needed.

(2) Control group 2: Weigh 130 parts of geranium by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material is burnt black, filter the oil after natural cooling, and use a cotton swab to evenly Apply to the affected area of skin lesions, and administer according to the dose of about 2g crude drug crude drug/cm ² skin lesions, once in the morning and once in the evening, 4 weeks of treatment is a course of treatment, and the effect will be judged after 3 courses of treatment. No internal medicine is needed during the treatment.

(4) Control group 3: Weigh 130 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material is burnt black, filter the oil after natural cooling, and use a cotton swab to evenly Apply to the affected area of skin lesions, and administer according to the dose of about 2g crude drug crude drug/cm ² skin lesions, once in the morning and once in the evening, 4 weeks of treatment is a course of treatment, and the effect will be judged after 3 courses of treatment. No internal medicine is needed during the treatment.

(5) Control group 4: Weigh 55 parts of wormwood and 75 parts of geranium by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the raw material is burnt black, filter and take after natural cooling Oil, evenly smear the skin lesion with a cotton swab, and administer according to the dose of about 2g crude drug crude drug/cm ² skin lesion, once in the morning and once in the evening, 4 weeks of treatment is a course of treatment, and the effect will be judged after 3 courses of treatment. No internal medicine is needed during the treatment.

(6) Control group five: take by weight 55 parts of wormwood and 75 parts of saxifrage, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the crude drug is scorched black, filter and take after natural cooling Oil, evenly smear the skin lesion with a cotton swab, and administer according to the dose of about 2g crude drug crude drug/cm ² skin lesion, once in the morning and once in the evening, 4 weeks of treatment is a course of treatment, and the effect will be judged after 3 courses of treatment. No internal medicine is needed during the treatment.

(7) Control group 6: Weigh 65 parts of geranium and 65 parts of saxifrage by weight, add 900 parts of olive oil, soak for 48 hours, then decoct on low heat for about 7 hours until the crude drug is burnt black, filter after natural cooling Take the oil, apply it evenly on the skin lesion with a cotton swab, and administer the drug according to the dose of about 2g crude drug/cm ² skin lesion, once in the morning and once in the evening, 4 weeks of treatment is a course of treatment, and the effect will be judged after 3 courses of treatment. During the treatment period, no internal medicine is needed.

6. Curative effect evaluation index

Refer to "Diagnosis and Curative Effect Criteria of TCM Diseases and Syndromes" and "Shanghai Traditional Chinese Medicine Diseases and Syndrome Diagnosis and Treatment Routine" (2nd Edition) to determine: clinical recovery: improvement rate ≥ 95%; marked effect: 70% ≤ improvement rate < 95%; effective: 30% %≤improvement rate<70%; invalid: improvement rate<30%. Total effective rate = recovery rate + marked rate + effective rate.

7. Treatment results

The statistical results of the total effective rate of each group are shown in Table 6. The results show that the total effective rate of the treatment group is significantly higher than that of the control group 1-control group 6 (P<0.05), and the difference from the control group 1-control group 3 reaches Extremely significant level (P<0.01), there was no significant difference between control group 4 and control group 5 (P>0.05). It can also be seen that the cure rate in the treatment group is fast, and the number of people who are cured and markedly effective after 3 courses of treatment is large .

Table 6 The statistical results of the total effective rate of each group

The above is only a preferred embodiment of the present invention, it should be pointed out that for those of ordinary skill in the art, without departing from the method of the present invention, some improvements and supplements can also be made, and these improvements and supplements should also be considered Be the protection scope of the present invention.

Claims (8)

1. treat a Chinese medicine composition for eczema, neurodermatitis or skin ulcer, it is characterized in that, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part.

2. Chinese medicine composition according to claim 1, is characterized in that, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 25-35 part, Herba Erodii 45-55 part, Herba Saxifragae 45-55 part.

3. Chinese medicine composition according to claim 2, is characterized in that, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 30 parts, Herba Erodii 50 parts, Herba Saxifragae 50 parts.

4. Chinese medicine composition according to claim 1, is characterized in that, the medicament of described Chinese medicine composition is lotion, tincture, oil preparation, Emulsion, ointment, plaster or gel.

5. Chinese medicine composition according to claim 4, is characterized in that, the medicament of described Chinese medicine composition is oil preparation.

6. Chinese medicine composition according to claim 5, is characterized in that, is olive oil as the vegetable oil of adjuvant in described oil preparation.

7. the preparation method of a Chinese medicine composition according to claim 1, it is characterized in that, comprise the following steps: take Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part by weight, add 600-1200 part olive oil, soak 24-72 hour, then low baking temperature decocts to crude drug burned black, crosses leaching oil after natural cooling.

8. the purposes of the arbitrary described Chinese medicine composition of claim 1-6 in preparation treatment dermatosis treating medicine, described dermatosis is eczema, neurodermatitis or skin ulcer.