CN108653479A - A kind of Chinese medicine composition and the preparation method and application thereof for treating refractory skin - Google Patents
A kind of Chinese medicine composition and the preparation method and application thereof for treating refractory skin Download PDFInfo
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- CN108653479A CN108653479A CN201810574250.4A CN201810574250A CN108653479A CN 108653479 A CN108653479 A CN 108653479A CN 201810574250 A CN201810574250 A CN 201810574250A CN 108653479 A CN108653479 A CN 108653479A
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- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- 230000003582 thrombocytopenic effect Effects 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating refractory skin, it counts in parts by weight, the Chinese medicine composition includes 80 120 parts of Rumex madaio, 35 60 parts of Radix Astragali, 10 30 parts of kuh-seng, 10 15 parts of the root bark of shaggy-fruited dittany, 5 12 parts of chameajasme, 8 15 parts of frutus cnidii, 0.01 0.04 parts of Chinese blister beetle.The invention also discloses a kind of preparation method and applications of Chinese medicine composition that treating refractory skin.The present invention carries out compatibility with Rumex madaio, Radix Astragali, kuh-seng, the root bark of shaggy-fruited dittany, chameajasme, frutus cnidii, Chinese blister beetle with special ratios, synergistic function enhances, it is verified through clinical test, the Chinese medicine composition of the present invention including dermatitis, eczema, psoriasis, the various refractory skins including ash (refers to, toe) first, tinea of feet and hands to having fine curative effect, small, quick, significant effect, the uneasy to recur and advantage that has no adverse reaction with skin irritatin.The preparation process of the present invention is simple, and operability is strong, and production cost is low, is suitable for mass producing.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and its system for treating refractory skin
Preparation Method and application.
Background technology
Due to environmental pollution, Abwehrkraft des Koepers decline, skin injury etc., various pathogenic bacteria especially fungi is easily drawn
Body skin and mucosal infections are sent out, lead to a variety of skin diseases, and the state of an illness is obstinate.Refractory skin refers to that clinical skin lesion is tight
Weight, touching not to be cured, recurrent exerbation, it is extremely difficult to a kind of skin disease of medical treatment.Including intractable psoriasis, eczema, anaphylactoid purpura, red
Yabbi sore, leucoderma, ichthyosis, chorionitis, allergic dermatitis, nettle rash, acne, chloasma, alopecia areata, alopecia, tinea pedis, ash refer to
It is first-class.
Refractory skin is a kind of common multiple abnormal reactive inflammation caused by a variety of internal and external factor comprehensive functions
Disease dermatoses.Its clinical characters is recurrent exerbation, and delay is refractory etc., and great body and mind pain is caused to patient.
Currently, the product for the treatment of refractory skin is as the main component with antibiotic, antimycotic Western medicine or hormone, deposit
In the big defect of side effect, be such as used for a long time not only can generate harmful effect to body, also will produce drug resistance and treated to lose
Effect.In addition also there is antimycotic pure Chinese medicinal preparation, this kind of drug effect is slow and therapeutic effect is not satisfactory.
Invention content
Of the existing technology in order to solve the problems, such as, it is small to skin irritatin that the purpose of the present invention is to provide a kind of, takes effect
Soon, significant effect, it is uneasy to recur and have no adverse reaction for treating the Chinese medicine composition of refractory skin.The present invention also public affairs
A kind of preparation method and application of Chinese medicine composition that treating refractory skin is opened.
To achieve the above object, the first aspect of the present invention provides a kind of Chinese traditional medicine composition for treating refractory skin
Object is counted in parts by weight, and the Chinese medicine composition includes 80-120 parts of Rumex madaio, 35-60 parts of Radix Astragali, 10-30 parts of kuh-seng, shaggy-fruited dittany
10-15 parts of skin, 5-12 parts of chameajasme, 8-15 parts of frutus cnidii, 0.01-0.04 parts of Chinese blister beetle.
Further, the Chinese medicine composition include 80-100 parts of Rumex madaio, it is 45-55 parts of Radix Astragali, 10-20 parts of kuh-seng, white
10-15 parts of fresh hide, 5-10 parts of chameajasme, 10-15 parts of frutus cnidii, 0.01-0.02 parts of Chinese blister beetle.
Further, the Chinese medicine composition include 100 parts of Rumex madaio, 50 parts of Radix Astragali, 15 parts of kuh-seng, 12 parts of the root bark of shaggy-fruited dittany,
10 parts of chameajasme, 10 parts of frutus cnidii, 0.02 part of Chinese blister beetle.
Further, the Chinese medicine composition is using the extract of raw material as the external preparation of active constituent.
The second aspect of the present invention provides a kind of preparation side of the Chinese medicine composition of above-mentioned treatment refractory skin
Method the described method comprises the following steps:
1) each raw material after drying, and coarse crushing are weighed in parts by weight;
2) each raw material for getting step 1) ready is added in medical glacial acetic acid, at a temperature of 10-15 DEG C, impregnates at least six
Month.
Further, it counts in parts by weight, the medical glacial acetic acid is 280-350 parts.
The third aspect of the present invention provides a kind of above-mentioned Chinese medicine composition in the medicine for preparing treatment refractory skin
Application in object.
Further, the refractory skin includes:The refractory skin includes but is not limited to:It is dermatitis, wet
Rash, psoriasis, ash (refer to, toe) first, tinea of feet and hands.
The effect of raw material selected by the present invention, is as follows:
Rumex madaio:For the root of polygonaceae plant Rumex madaio.Nature,taste and action:It is cool in nature, it is bitter, pungent.Function:Heat-clearing, the row stasis of blood, is killed
Worm, removing toxic substances.Rumex madaio is civil for treating a variety of diseases, as (such as pure bleeding, thrombocytopenic are purple for hemorrhagic disease
Purplish or white patches on the skin), skin disease (flat wart, eczema, condyloma acuminatum and other fash), wound (traumatic injury, acute lumbar muscle sprain), digestibility disease
Sick (simple indigestion), inflammatory disease (bedsore, periappendiceal abscess).Chemical constitution study shows that Rumex madaio contains greatly
Flavine, Physcion, Chrysophanol, rumicin and a large amount of tannins.Modern pharmacological studies have shown that:The rumicin contained in Rumex madaio
With antibacterium, fungi, virus and parasite effect.
Radix Astragali:For leguminous herbaceous plant's astragalus mongolicus, the root of Astragalus membranacus.It is sweet in flavor, slightly warm in nature, return lung, spleen, liver and kidney channel.
With invigorating qi for strengthening superficies, profit water detumescence, pus draining and toxin expelling, myogenic and other effects.Modern research shows that Radix Astragali containing saponin, sucrose, polysaccharide,
The various trace elements such as a variety of amino acid, folic acid and selenium, zinc, copper.Have enhancing body's immunity, liver protection, diuresis, anti-aging,
Resisting stress, decompression and wide antibacterial action.
Kuh-seng:This product is the dry root of legume kuh-seng.Bitter, it is cold in nature.The thoughts of returning home, liver, stomach, large intestine, bladder warp.Work(
Energy:Heat-clearing and damp-drying drug, desinsection, diuresis.It cures mainly:It for hot dysentery, has blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema is wet
Sore, pruitus, mange leprosy;Control trichomonas vaginitis outside.Chemical constitution study shows kuh-seng containing a variety of alkaloids and a variety of
Flavones.Modern pharmacological studies have shown that kuh-seng has antipathogen effect, there is different degrees of suppression to certain common dermatophytes
It makes and uses.
The root bark of shaggy-fruited dittany:For the dry root skin of Rutaceae shaggy-fruited dittany category herbaceos perennial shaggy-fruited dittany, it is commonly called as stereotyped writing ox, in being common
Medicinal material.The root bark of shaggy-fruited dittany is dept. of dermatology's conventional Chinese medicine, has heat-clearing and damp-drying drug, wind-dispelling removing toxic substances, antipruritic effect, is chiefly used in treating herpes simplex
The illnesss such as poison, yellow water leaching glass, eczema, rubella, pruitus, mange, yellow subcutaneous ulcer, acute, chronic hepatitis.Studies have shown that the root bark of shaggy-fruited dittany includes
The compounds such as alkaloid, limonin, flavones, sequiterpene and its glycoside, steroidal have a variety of pharmacological activity, and main includes anti-
Tumour, antibacterial, anti-inflammatory, pest-resistant, antiallergy, hemostasis, anti-oxidant etc..
Chameajasme:Alias Chinese Stellera Root, gelsemium elegan, belong to Thymelaeceae rootstock type herbaceos perennial, and radix euphorbiae lantu has for meadow
Poisonous plant.Its root can be used as medicine, and have eliminating the phlegm, control long-pending efficiency, external application can control mange, contain anticancer component in root extract.Chemistry
Composition Study shows chameajasme containing sterol, phenolic constituent, amino acid, triterpenes and toxic polymeric organic acid.Chameajasme exists
It can be clinically used for treatment skin disease, tuberculosis.
Frutus cnidii:The dry mature fruit of samphire cnidium monnieri.It is warm-natured, acrid flavour, hardship.Return kidney channel.Effect:Warm kidney is strong
Sun, eliminating dampness, wind-dispelling, desinsection.Chemical constitution study show the main component contained by frutus cnidii be pinane is dilute, isovaleric acid borneol acetate,
Osthole, Columbianetin, bergapten, Osthole, isopimpinellin etc..Modern pharmacological studies have shown that having
Anti-trichomonal, it is antimycotic the effects that.
Chinese blister beetle:It is commonly called as blister beetle, belongs to Insecta coleoptera Meloidae insect.It is chiefly used in clinical tumor and skin disease etc. now
Treatment, significant effect.But Chinese blister beetle is very toxic, takes orally excessive, may occur in which Nausea and vomiting or discharge watery blood sample object, eilema, with
Cause the poisoning symptoms such as blood urine, severe patient may be dead.Modern study finds that Chinese blister beetle main component is cantharidin compound, also contains
There are protein, amino acid, fat and aliphatic acid, ucleosides, inorganic elements etc..
Chinese medicine thinks skin disease mostly because of inernal injuries caused by seven emotions, and obstruction of QI, strongly fragrant longization is fiery, scorchingly hot to accumulate volt ying blood;Or because diet loses
Section, taste become estranged, stasis intrinsic heat, and it is evil to feel wind-heat poison again so that passages through which vital energy circulates blocks, qi and blood condensation, failure of skin and muscle to be nourished and fall ill.If sick long
Or recurrent exerbation, cloudy blood consume, qi-blood disharmony, wind is given birth in dryness-transformation, so that blood is dry.
For the above-mentioned interpretation of the cause, onset and process of an illness, for the present invention in the treatment with clearing heat and cooling blood Zhi Qiben, its mark is controlled in dispelling wind and arresting itching.Soil is big in side
Yellow, Radix Astragali clearing heat and cooling blood purging intense heat dampness removing;Kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii dispelling wind and arresting itching;Chameajasme, Chinese blister beetle eliminating the phlegm control long-pending promoting the circulation of qi and live
The stasis of blood.The cooperation of all medicines, make blood-head obtain clearly, it is damp and hot get profit, itch must stop, promoting blood circulation and removing blood stasis, reach the purpose of simultaneous treatment of principal and subordinate symptoms.
The invention has the advantages that:
1, the present invention is matched with Rumex madaio, Radix Astragali, kuh-seng, the root bark of shaggy-fruited dittany, chameajasme, frutus cnidii, Chinese blister beetle with special ratios
5, synergistic function enhancing, verified through clinical test, Chinese medicine composition of the invention to include dermatitis, eczema, psoriasis,
Various refractory skins including grey (referring to, toe) first, tinea of feet and hands have fine curative effect, effect small, quick with skin irritatin
Fruit is notable, the uneasy to recur and advantage that has no adverse reaction.
2, preparation process of the invention is simple, and operability is strong, and production cost is low, is suitable for mass producing.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
A kind of Chinese medicine composition for treating refractory skin, including it is 80 grams of Rumex madaio, 35 grams of Radix Astragali, 30 grams of kuh-seng, white
10 grams of fresh hide, 5 grams of chameajasme, 15 grams of frutus cnidii, 0.01 gram of Chinese blister beetle.
The preparation method of the Chinese medicine composition of the present embodiment, includes the following steps:
1) each raw material after drying, and coarse crushing are weighed;
2) each raw material for getting step 1) ready is added in 280 grams of medical glacial acetic acid, at a temperature of 10 DEG C, impregnates at least six
A month.
Embodiment 2
A kind of Chinese medicine composition for treating refractory skin, including it is 100 grams of Rumex madaio, 50 grams of Radix Astragali, 15 grams of kuh-seng, white
12 grams of fresh hide, 10 grams of chameajasme, 10 grams of frutus cnidii, 0.02 gram of Chinese blister beetle.
The preparation method of the Chinese medicine composition of the present embodiment, includes the following steps:
1) each raw material after drying, and coarse crushing are weighed;
2) each raw material for getting step 1) ready is added in 300 grams of medical glacial acetic acid, at a temperature of 15 DEG C, impregnates at least six
A month.
Embodiment 3
A kind of Chinese medicine composition for treating refractory skin, including it is 85 grams of Rumex madaio, 55 grams of Radix Astragali, 15 grams of kuh-seng, white
10 grams of fresh hide, 12 grams of chameajasme, 12 grams of frutus cnidii, 0.05 gram of Chinese blister beetle.
The preparation method of the Chinese medicine composition of the present embodiment, includes the following steps:
1) each raw material after drying, and coarse crushing are weighed;
2) each raw material for getting step 1) ready is added in 280 grams of medical glacial acetic acid, at a temperature of 12 DEG C, impregnates at least six
A month.
Embodiment 4
A kind of Chinese medicine composition for treating refractory skin, including it is 120 grams of Rumex madaio, 60 grams of Radix Astragali, 10 grams of kuh-seng, white
15 grams of fresh hide, 8 grams of chameajasme, 8 grams of frutus cnidii, 0.04 gram of Chinese blister beetle.
The preparation method of the Chinese medicine composition of the present embodiment, includes the following steps:
1) each raw material after drying, and coarse crushing are weighed;
2) each raw material for getting step 1) ready is added in 350 grams of medical glacial acetic acid, at a temperature of 10 DEG C, impregnates at least six
A month.
Embodiment 5
A kind of Chinese medicine composition for treating refractory skin, including it is 110 grams of Rumex madaio, 40 grams of Radix Astragali, 20 grams of kuh-seng, white
15 grams of fresh hide, 10 grams of chameajasme, 10 grams of frutus cnidii, 0.02 gram of Chinese blister beetle.
The preparation method of the Chinese medicine composition of the present embodiment, includes the following steps:
1) each raw material after drying, and coarse crushing are weighed;
2) each raw material for getting step 1) ready is added in 320 grams of medical glacial acetic acid, at a temperature of 12 DEG C, impregnates at least six
A month.
Test example
In order to illustrate Chinese medicine composition of the invention to the therapeutic effect of refractory skin, the present invention has carried out following treatment
Effect experiment.
Test example 1
1, general information
Choose the 158 patients work for dermatitis and eczema being diagnosed as through clinical examination in January, -2010 in January, 2000
For research object, wherein man 82, female 76;Age 21-76 Sui, average age (45 ± 5.7) year, infection time 1-15.
Patient is divided into treatment group and control group according to random digits table, every group each 79, two groups of patients are in gender, age and disease
Difference does not have statistical significance (P in the general information such as feelings type>0.05) it, can be compared.
2, evaluation criterion
It cures:The clinical symptoms such as itch, blister, the erythema of patient improve or all disappear substantially after the treatment, skin lesion
Large area eliminates no less than 80%;
Effectively:The symptoms such as itch, the erythema of patient are centainly improved after the treatment, and skin lesion area subsides in 30-80%;
In vain:I.e. symptom is not up to above-mentioned standard.
3, therapy
Treatment group:Affected part and around smear embodiment 1 made from Chinese medicine composition, three times a day, seven days for one treatment
Journey.
Control group:Oral Chinese holly Desloratadine piece (Yangtze River medicine company) treatment, dosage:8.8mg × 6 piece, one times/day, seven
Days as a treatment course.
4, result
By one and two course of therapy, two groups of clinical therapeutic efficacy comparing result is shown in Table 1.
Table 1
It is right to the healing of the two and effective patient progress follow-up, treatment group's Patients on Recurrence 3, recurrence rate 4.2% respectively
According to a group recurrence 14, recurrence rate 23.7%.
Typical case:
Flood certain, female, 48 years old, rash starting both hands since 2005 repeatedly, conscious itch was once diagnosed as in multiple hospitals " wet
Rash " takes orally Chinese holly Desloratadine piece, has no apparent curative effect, often repeatedly.Using the Chinese medicine composition of the embodiment of the present invention 4,
3 times a day, after 3 days, patient's itch is substantially reduced, using a course for the treatment of, returns to normal.Follow-up 1 year is without recurrence.
Test example 2
1, general information
It chooses and is diagnosed as psoriasic 143 patients as research object through clinical examination in June, -2012 in June, 2000,
Diagnostic criteria:Based on red inflamed papules, maculopapule and the patch that differs in size, upper shoe multilayer silvery white phosphorus bits are scraped for skin lesion
Except the visible one layer of bright film of the scales of skin that peel off, there can be petechial hemorrhage under film.Fash form can have a drop-wise, coin shape, map shape,
The multiple types such as shape are mixed, but boundary is apparent.Wherein, man 81, female 62;Age 12-65 Sui, average age (38 ± 4.3)
Year, infection time -20 years 3 months.Patient is divided into treatment group 72 and control group 71, two groups of trouble according to random digits table
Person's difference in the general information such as gender, age and state of an illness type does not have statistical significance (P>0.05) it, can carry out pair
Than.
2, evaluation criterion
Recovery from illness:Skin lesion is subsided, or only leaves a small number of pigmentations, and symptom disappears, and laboratory indexes are normal.
Effectively:Skin lesion partial remission, symptom improve, and laboratory indexes are close to normally.
In vain:Skin lesion recession unobvious or clinical symptoms are counter sees deterioration.
3, therapy
Treatment group:Affected part and around smear embodiment 2 made from Chinese medicine composition, three times a day, seven days for one treatment
Journey.
Control group:It gives Calcipotriol ointment (Chongqing Huapont Pharmaceutical Co., Ltd.) and embrocates affected part, twice daily, be within seven days
One course for the treatment of.
4, result
By two and four course of therapy, two groups of clinical therapeutic efficacy comparing result is shown in Table 2.
Table 2
The healing to two groups and effective patient progress follow-up, treatment group's Patients on Recurrence 1, recurrence rate 1.5% are right respectively
According to a group recurrence 10, recurrence rate 18.2%.
Typical case:
Niu, man, 48 years old, since 2001 start head there is red rash, rear fash increases, in buttocks, shank, elbow pass
Existing sheet fash at section, is psoriasis through hospital therapy.Once it was treated using a variety of medicine for external applications, oral traditional Chinese medicine, Relapse rate
Breaking-out, can not eradicate always.The Chinese medicine composition that patient smears the embodiment of the present invention 2 in June, 2015 uses two 3 times a day
After a course for the treatment of, the symptoms were significantly improved, in order to consolidate the course for the treatment of, is continuing with a course for the treatment of, is almost recovered, and follow-up 1 year is without recurrence.
Test example 3
1, general information
It chooses and is diagnosed as 236 patients of grey (referring to, toe) first as research through clinical examination in May, -2011 in May, 1998
Object, wherein man 135, female 101;Age 10-70 Sui, average age (47 ± 3.6) year, infection time -18 years 1 month.
Patient is divided into treatment group and control group according to random digits table, every group each 118, two groups of patients gender, the age and
Difference does not have statistical significance (P in the general information such as state of an illness type>0.05) it, can be compared.
2, evaluation criterion
It cures:Sick first completely disappears, newborn deck smooth, bright color, negative fungal examination as disease-free deck;
It is effective:Sick first recession face is more than 70%, and sick first relatively puts down clean, negative fungal examination or visible a small amount of broken or deformation
Mycelia and spore;
Effectively:Between sick first recession 30-70%, fungus microscope examination is positive;
In vain:Sick first, which subsides, is less than 30%, and fungus microscope examination is positive.
3, therapy
Treatment group:The Chinese medicine composition that embodiment 4 is soaked with absorbent cotton is coated in sick first, with adhesive bandage or gauze packet
On, sick onychomalacia, separation after 3 days scrape off the empty loose part of nail with blade.The Chinese medicine composition is dipped with cotton swab daily later to apply
In suffering from first, three times, 7 days as a course for the treatment of for daily coating.
Control group:Oral hydrochloride terbinafine (Nanjing Cuccess Pharmaceutical Co., Ltd.), once a day, 7 days are one
A course for the treatment of.
4, result
By one and three course of therapy, two groups of clinical therapeutic efficacy comparing result is shown in Table 3.
Table 3
The healing to two groups and effective patient progress follow-up, treatment group's Patients on Recurrence 5, recurrence rate 4.4% are right respectively
According to a group recurrence 23, recurrence rate 24.0%.
Typical case:
Lee, female, 25 years old, left index finger and middle finger suffered from onychomycosis, and nail is muddy, thickens, surface irregularity, changes colour,
Suffer from onychomycosis 5 years, using the Chinese medicine composition of the embodiment of the present invention 5, daily night, which is applied to, suffers from first, and packet was removed with second day
It pricks, a course for the treatment of is used continuously, onychomycosis falls off, intact new first is slowly grown from nail root, to consolidate curative effect, continues to make
With a course for the treatment of, recovery from illness, follow-up is so far without recurrence.
Test example 4
1, general information
It chooses in August, 1996 in August, -2010 and is diagnosed as 168 patients of Keratotic tinea hand or pedis as grinding through clinical examination
Study carefully object, diagnostic criteria:Angling, drying and the scales of skin that peel off, it is gradual that disease progression gradually spreads to heel, vola pedis and sufficient side, the scales of skin that peel off
Increase, be gradually hardened, angling is apparent, and winter aggravates, and chaps, and forms crack, bleeding and pain and influences to walk.Wherein,
Man 96, female 72;Age 12-60 Sui, average age (42 ± 2.8) year, infection time -22 years 2 months;Random digits table
Patient is divided into treatment group and control group, every group each 84, two groups of patients are in general information such as gender, age and state of an illness types
Upper difference does not have statistical significance (P>0.05) it, can be compared.
2, evaluation criterion
Therapeutic index=(prior treatment integral-treatment integral)/prior treatment integral × 100%.
Recovery from illness:Skin lesion, itch all disappear, scurf negative fungal examination.
It is effective:Skin lesion, scabies largely disappear, and therapeutic index >=70% or has a small amount of breaking deformation spore at negative fungal examination
Son, mycelia.
Effectively:Skin lesion, itch partial disappearance, therapeutic index 30-69%, fungus microscope examination have a small amount of mycelia, spore.
In vain:Compared with pre-treatment, various aspects are without progress, index < 30%.
3, therapy
Treatment group:Suffer from foot using the Chinese medicine composition immersion of embodiment 5 or suffer from hand 30 minutes, one time a day, 7 days are one
The course for the treatment of.
Control group:Sertaconazole emulsifiable paste (Hainan Haishen Tongzhou Pharmaceutical Co., Ltd.), twice daily, 7 are applied outside affected part
Days as a treatment course.
4, result
By one and two course of therapy, two groups of clinical therapeutic efficacy comparing result is shown in Table 4.
Table 4
The healing to two groups and effective patient progress follow-up, treatment group's Patients on Recurrence 2, recurrence rate 2.5% are right respectively
According to a group recurrence 8, recurrence rate 11.4%.
Typical case:
Ma, man, 35 years old, suffers from the ringworm of the foot 8 years, and foot blister, festers, perspiring, very itching, cacosmia, is fungi through hospital diagnosis
Infection, a variety of drug therapies such as used Da Kening, vinegar hang in the balance, fail to cure, use the Chinese medicine of the embodiment of the present invention 1
Composition, after a course for the treatment of, symptom is substantially reduced, continues and uses 2 courses for the treatment of, and symptom disappears, and recovery from illness, follow-up is so far without recurrence.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.
Claims (8)
1. a kind of Chinese medicine composition for treating refractory skin, which is characterized in that count in parts by weight, the Chinese medicine composition
Including 80-120 parts of Rumex madaio, 35-60 parts of Radix Astragali, 10-30 parts of kuh-seng, 10-15 parts of the root bark of shaggy-fruited dittany, 5-12 parts of chameajasme, frutus cnidii
8-15 parts, 0.01-0.04 parts of Chinese blister beetle.
2. the Chinese medicine composition for the treatment of refractory skin according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object includes 80-100 parts of Rumex madaio, 45-55 parts of Radix Astragali, 10-20 parts of kuh-seng, 10-15 parts of the root bark of shaggy-fruited dittany, 5-10 parts of chameajasme, cnidium monnieri
10-15 parts sub-, 0.01-0.02 parts of Chinese blister beetle.
3. the Chinese medicine composition for the treatment of refractory skin according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object includes 100 parts of Rumex madaio, 50 parts of Radix Astragali, 15 parts of kuh-seng, 12 parts of the root bark of shaggy-fruited dittany, 10 parts of chameajasme, 10 parts of frutus cnidii, Chinese blister beetle 0.02
Part.
4. the Chinese medicine composition for the treatment of refractory skin according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object is using the extract of raw material as the external preparation of active constituent.
5. a kind of preparation method of the Chinese medicine composition for the treatment of refractory skin described in claim 1, which is characterized in that institute
The method of stating includes the following steps:
1) each raw material after drying, and coarse crushing are weighed in parts by weight;
2) each raw material for getting step 1) ready is added in medical glacial acetic acid, at a temperature of 10-15 DEG C, impregnates at least six months.
6. the preparation method of the Chinese medicine composition for the treatment of refractory skin according to claim 5, which is characterized in that press
Parts by weight meter, the medical glacial acetic acid are 280-350 parts.
7. application of the Chinese medicine composition described in claim 1 in the drug for preparing treatment refractory skin.
8. application according to claim 7, which is characterized in that the refractory skin includes but is not limited to:Dermatitis,
Eczema, psoriasis, ash (refer to, toe) first, tinea of feet and hands.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110101775A (en) * | 2019-06-14 | 2019-08-09 | 李延海 | It is a kind of to treat dermopathic Chinese medicine composition |
CN111467388A (en) * | 2020-06-10 | 2020-07-31 | 张奇虎 | Ointment for effectively treating psoriasis and preparation method thereof |
CN112439006A (en) * | 2020-11-21 | 2021-03-05 | 南昌市第一医院 | Traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and preparation method thereof |
CN112439020A (en) * | 2020-11-21 | 2021-03-05 | 南昌市第一医院 | Traditional Chinese medicine composition and tincture for treating chronic eczema and preparation method thereof |
CN113940962A (en) * | 2021-11-03 | 2022-01-18 | 华农(肇庆)生物产业技术研究院有限公司 | Traditional Chinese medicine preparation for treating pet skin diseases and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1137394A (en) * | 1995-07-06 | 1996-12-11 | 孔繁营 | Traditional Chinese medicine kexian preparation for treating tinea and its preparing method |
CN1087950C (en) * | 1999-11-05 | 2002-07-24 | 卞勇 | Dermatosis treating Chinese medicine and its preparation |
CN103550602A (en) * | 2013-11-25 | 2014-02-05 | 陈正洪 | Miao liquid medicine for treating skin infection and barbiers and foot odor |
-
2018
- 2018-06-06 CN CN201810574250.4A patent/CN108653479A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1137394A (en) * | 1995-07-06 | 1996-12-11 | 孔繁营 | Traditional Chinese medicine kexian preparation for treating tinea and its preparing method |
CN1087950C (en) * | 1999-11-05 | 2002-07-24 | 卞勇 | Dermatosis treating Chinese medicine and its preparation |
CN103550602A (en) * | 2013-11-25 | 2014-02-05 | 陈正洪 | Miao liquid medicine for treating skin infection and barbiers and foot odor |
Non-Patent Citations (3)
Title |
---|
仲崇凤: "神经性皮炎治验一方 ", 《中医药信息》 * |
沈晓峰: "黄芪在皮肤病治疗中的应用", 《新疆中医药》 * |
闵捷: "《毒性中药的临床应用》", 30 April 1992, 中国中医药出版社 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110101775A (en) * | 2019-06-14 | 2019-08-09 | 李延海 | It is a kind of to treat dermopathic Chinese medicine composition |
CN111467388A (en) * | 2020-06-10 | 2020-07-31 | 张奇虎 | Ointment for effectively treating psoriasis and preparation method thereof |
CN112439006A (en) * | 2020-11-21 | 2021-03-05 | 南昌市第一医院 | Traditional Chinese medicine composition and tincture for treating intractable neurodermatitis and preparation method thereof |
CN112439020A (en) * | 2020-11-21 | 2021-03-05 | 南昌市第一医院 | Traditional Chinese medicine composition and tincture for treating chronic eczema and preparation method thereof |
CN113940962A (en) * | 2021-11-03 | 2022-01-18 | 华农(肇庆)生物产业技术研究院有限公司 | Traditional Chinese medicine preparation for treating pet skin diseases and preparation method thereof |
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