CN104707008B - A kind of composite drug and preparation method for preventing chickens respiratory disease - Google Patents
A kind of composite drug and preparation method for preventing chickens respiratory disease Download PDFInfo
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- CN104707008B CN104707008B CN201510111361.8A CN201510111361A CN104707008B CN 104707008 B CN104707008 B CN 104707008B CN 201510111361 A CN201510111361 A CN 201510111361A CN 104707008 B CN104707008 B CN 104707008B
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Abstract
The invention discloses a kind of composite drug and preparation method for preventing chickens respiratory disease, which is made of the component of following parts by weight：99.96 ~ 99.98 parts of 0.02 ~ 0.04 part of probiotics, 0.02 ~ 0.04 part of vitamin A and Chinese medicine additive；The probiotics includes following microorganism：Lactic acid bacteria, bacillus, hay bacillus；The Chinese medicine additive includes following bulk pharmaceutical chemicals：Fructus Forsythiae, pig's bile, costus root, stone reed, lophatherum gracile, Chinese gall, the bark of ash, Radix Glycyrrhizae, the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae, thizoma curculiginis, hyacinth bean, madder, the compound of glauber-salt and liquorice, dianthus superbus, rush, rhizoma menispermi etc..The probability that chicken group's breathing problem occurs can be effectively reduced, enhance chicken premunition and improve chicken survival rate, ensure the normal growth and development of chicken group, suitable for 1 ~ 20 age in days broiler chicken using, production cost is low, production and using it is simple, using effect is apparent, has no adverse reaction, there are popularization and application.
Description
Technical field
The present invention relates to a kind of composite drugs and preparation method for preventing chickens respiratory disease.
Background technology
The species of chicken respiratory tract disease：A. respiratory diseases caused by bacterium.Chronic respiratory tract disease (septic mycoplasmosis),
Aspergillosis；B. respiratory diseases caused by virus.Such as ewcastle disease (N D), infective bronchitis (IB), infectious laryngotracheitis
(ILT), influenza (AI)；C. respiratory diseases caused by parasite.Such as Cryptosporidiosis, leucocyte protozoon disease, endotracheal suction parasitosis.
For the epidemic characteristic 1. of chicken respiratory tract disease with the fast development of poultry husbandry, the species of chicken respiratory tract disease is more and more.Chicken at present
The characteristics of old complaint, which is presented, in respiratory diseases continues to occur, and new disease continuously emerges, such as ewcastle disease, infective bronchitis, infectiousness larynx
Tracheitis, Frustrate blood and mycoplasma disease, colibacillosis, infective rhinitis etc., old disease occur and prevalence constantly all the year.At the same time,
Many new diseases successively occur, such as chicken influenza, Glandular Stomach Type Infections Bronchitis.In these emerging epidemic diseases, at present
Especially pay attention to the prevention and control of chicken influenza epidemic disease, the generation for preventing this sick and prevalence are the task of top priority.2. there is cause of disease variation, exempt from
Epidemic disease inhibits, the case of atypia disease increases.In recent years, each chicken house is all using various vaccine immunities, but many at present general
Logical vaccine is increasingly difficult in some aspect of respiratory disease of prevention and control, and the chicken group after being immunized is caused not necessarily all to generate strong guarantor
Protect power.It will make chicken mass-sending disease when running into external environment and have wild poison pollution.3. the danger of some bacteriosises and parasitic disease
Evil is on the rise.With feeding chicken in largely scale field increase and its continuous expansion of scale, environmental pollution are also increasingly severe.Bacterium
Property disease and parasitic disease showed increased, wherein many cause of diseases are widely present in poultry environment, can propagate through a variety of ways,
These pathogenic microorganisms have become the normal in cause of disease of chicken farm.More main reasons is that poultry family is blindly heavy dose of to abuse antibacterial
Drug makes some common bacterias generate stronger drug resistance, and after morbidity, all drug are all hard to work.4. mixed infection
Increase with the case of scabies secondary infection.In production practices, as epidemic disease increases, cultivation density increases, in addition environment disinfected it is not tight,
The factors such as precautionary measures are ineffective, single cause of disease is clinically rare in chicken disease, and many cases are by two or more cause of disease, to same
One chicken body generates pathogenic effects, and the case of accompanying infection, scabies secondary infection and mixed infection rises.
At present due to the complexity of chicken respiratory disease, therefore it is used for treating there is no specific medicament, chicken respiratory tract disease is using west
When medicine is treated, the course for the treatment of is long, and western medicine composition is easily remained in chicken body, and the health of the mankind can be influenced after edible.
And Chinese medicine is in line with illness of the principle for above-mentioned complexity for consolidating righting, before there is fine therapeutic effect and application
Scape, the present invention provide the medicament of a kind of probiotics, vitamin A and the compound treatment chicken respiratory tract disease of Chinese medicine additive, have
Effect ground treatment chicken respiratory disease, adds survival rate.
The content of the invention
In order to solve problem above, the present invention provides a kind of composite drug that can treat and prevent chicken respiratory tract disease,
The composite drug therapeutic effect is apparent, and toxic side effect is small, quick.
A kind of composite drug for preventing chickens respiratory disease, is made of the component of following parts by weight：
99.92~99.96 parts of 0.02~0.04 part of probiotics, 0.02~0.04 part of vitamin A and Chinese medicine additive；
The probiotics includes lactic acid bacteria, bacillus and hay bacillus, the lactic acid bacteria, bacillus and withered grass bar
The quantity ratio (cfu) of bacterium is：30~50：20~35：25~35, the wherein probiotics is 10 containing viable count12~8 ×
1012cfu/g。
The Chinese medicine additive includes the bulk pharmaceutical chemicals of following parts by weight：40~50 parts of Fructus Forsythiae, 5~15 parts of pig's bile, costus root 5
~10 parts, 30~40 parts of stone reed, 30~45 parts of lophatherum gracile, 5~10 parts of Chinese gall, 10~20 parts of the bark of ash, 30~60 parts of Radix Glycyrrhizae, female
Loyal 20~30 parts of son, 20~25 parts of Rhizoma Atractylodis Macrocephalae, 5~8 parts of thizoma curculiginis, 25~35 parts of hyacinth bean, 30~40 parts of madder, the compound of glauber-salt and liquorice 20~25
Part, 15~25 parts of dianthus superbus, 30~45 parts of rush, 25~35 parts of rhizoma menispermi, 5~15 parts of wilsonii.
The preparation method of the composite drug of the prevention chickens respiratory disease, by each component of Chinese medicine additive it is dry,
It is crushed after mixing, crosses 60~100 mesh sieves to get Chinese medicine additive；Then each component and vitamin A of probiotics are added in,
Up to the composite drug of prevention chickens respiratory disease, the dosage form of the composite drug is pulvis.
Broiler chicken application method：It in growth of meat chicken 1-20 days, is fed with the ratio spice of mass percent 1~2%, i.e., often
100kg feeds add 1~2kg composite drugs of the present invention, to prevent the adverse effect of feed and environment to viable bacteria activity, in proportion
The same day prepares, and has been fed on the day of free choice feeding.
The lactic acid bacteria, bacillus (Bacillus), hay bacillus and vitamin A buy institute by commercial sources
, it is powder preparation.
Preferably, a kind of composite drug for preventing chickens respiratory disease, is made of the component of following parts by weight：
99.94 parts of 0.03 part of probiotics, 0.03 part of vitamin A and Chinese medicine additive；
The quantity ratio (cfu) of the lactic acid bacteria, bacillus and hay bacillus is：40：30：30, wherein the Tiny ecosystem system
Agent is 5 × 10 containing viable count12cfu/g。
The Chinese medicine additive includes the bulk pharmaceutical chemicals of following parts by weight：45~50 parts of Fructus Forsythiae, 5~8 parts of pig's bile, costus root 5
~8 parts, 35~38 parts of stone reed, 40~45 parts of lophatherum gracile, 5~8 parts of Chinese gall, 10~15 parts of the bark of ash, 45~55 parts of Radix Glycyrrhizae, glossy privet
25~30 parts of son, 20~25 parts of Rhizoma Atractylodis Macrocephalae, 5~6 parts of thizoma curculiginis, 30~35 parts of hyacinth bean, 32~38 parts of madder, 22~23 parts of the compound of glauber-salt and liquorice,
20~25 parts of dianthus superbus, 35~45 parts of rush, 30~35 parts of rhizoma menispermi, 5~10 parts of wilsonii.
It is further preferred that the Chinese medicine additive includes the bulk pharmaceutical chemicals of following parts by weight：45 parts of Fructus Forsythiae, 8 parts of pig's bile,
6 parts of costus root, 35 parts of stone reed, 42 parts of lophatherum gracile, 6 parts of Chinese gall, 15 parts of the bark of ash, 50 parts of Radix Glycyrrhizae, 28 parts of the fruit of glossy privet, Rhizoma Atractylodis Macrocephalae 22
Part, 5 parts of thizoma curculiginis, 30 parts of hyacinth bean, 35 parts of madder, 22 parts of the compound of glauber-salt and liquorice, 20 parts of dianthus superbus, 40 parts of rush, 30 parts of rhizoma menispermi, wilsonii
6 parts.
Lactic acid bacteria is as follows in role of the present invention：
(1) promote the absorption of the nutriments such as protein, monose and calcium, magnesium, it is a large amount of beneficial to objects to generate vitamin B complex etc.
Matter.
(2) increase intestinal beneficial flora, improve gastrointestinal function, recover intestinal flora balance, form antibacterial biological screen
Barrier, safeguards body health.
(3) breeding of spoilage organisms is inhibited, the toxin that resolution spoilage organisms generates removes enteron aisle rubbish.
(4) immunoregulation effect, strengthen immunity and resistance.
Bacillus is as follows in role of the present invention：
(1) organic matter decomposition power is strong：While multiplication, the amylase of high activity can be disengaged, the macromolecular that hardly possible is decomposed
Substance decomposition is into available small-molecule substance.
(2) abundant metabolism product is generated：Synthesize the substances such as a variety of organic acids, enzyme, physiological activity and other a variety of appearances
The nutrient being easily utilized.
(3) it is antibacterial, harmful power of going out is strong：With the advantage of taking up space, inhibit the life of the harmful microbes such as harmful bacteria, pathogen
Long breeding.Bacillus can generate a variety of digestive ferments, and animal is helped to digest and assimilate nutriment.(4) bacillus has
Stronger protease, amylase and lipase active, while also there is the enzyme of complex carbohydrates in degradation feed, such as pectin
Enzyme, dextranase, cellulase etc., these enzymes can destroy the cell membrane of plant feed cell, promote the nutriment of cell
It releases, and the anti-nutritional factors in feed can be eliminated, reduce the obstacle that anti-nutritional factors utilizes animal digestion.
Hay bacillus is as follows in role of the present invention：
(1) subtilin, polymyxins, nystatin, gramicidins generated during hay bacillus thalli growth etc.
Active material, these active materials have apparent inhibitory action to the conditioned pathogen of pathogenic bacteria or autogenous infection.
(2) hay bacillus consumes rapidly the free oxygen in environment, causes enteron aisle hypoxemia, promotes to grow beneficial to anaerobic bacteria, and
The organic acids such as lactic acid are generated, reduce enteron aisle pH value, inhibit other pathogenic bacteria growths indirectly.
(3) growth and development of stimulating animal immune organ, activation T, bone-marrow-derived lymphocyte, improves immunoglobulin and antibody water
It is flat, enhance cellular immunity and humoral immune function, improve herd immunity.
(4) enzymes such as hay bacillus thalline itself synthesis alpha-amylase, protease, lipase, cellulase, in alimentary canal
In play a role together with the in vivo digestive enzymes of animal.
(5) a variety of B family vitamins such as vitamin B1, B2, B6, niacin can be synthesized, improve interferon and macrophage in animal body
The activity of cell.
The pharmacological property of the Chinese medicine material medicine of the present invention is as follows：
Fructus Forsythiae, nature and flavor：It is bitter, cool.Channel tropism：Enter the heart, liver, gallbladder channel.Major function：Heat-clearing, removing toxic substances, dissipating bind, detumescence.Control temperature
Heat, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.
Pig's bile, nature and flavor：It is bitter, cold, salty.Effect：Beneficial lung, tonifying spleen are moisturized.Control quench one's thirst, constipation, jaundice, pertussis,
Asthma, diarrhea, hot eyes, larynx numbness, stare at ear, carbuncle swells at dysentery.
Costus root, pharmacological property：Arduous, temperature.Return stomach, spleen, liver, large intestine channel.Drug effect：Internal heat anticance, promoting qi circulation and relieving pain, doctor's sore disappear
It swells, there is antibacterial action.Effect to respiratory system.Zoopery shows：Aplotaxis auriculata aqueous extract, alcohol extract, volatile oil
And total alkaloid can act on the cause convulsion of trachea and bronchus antihistamine and acetylcholine, available for its work of bronchial asthma
It is similar to papaverine with feature, that is, it directly acts on bronchial smooth muscle and is allowed to expand the effects with fan to walk CNS inhibition related.
Aqueous extracts, alcohol extract, go lactone volatile oil and total alkaloid to be injected intravenously to have certain inhibition to make anesthetized dog breathing volatile oil
With frequency can be slowed down, to reduce amplitude wherein stronger with the effect of volatile oil, but Ginkgolide Component contained by volatile oil is to breathing without bright
Development is rung.
Stone reed, pharmacological property：Bitter sweet, it is cool, enter lung, bladder two passes through.Effect：Promoting diuresis for stranguria, clearing lung-heat expel the heat-evil, control leaching pain, hematuria, urine
Road calculus, ephritis, uterine bleeding, dysentery, cough with lung heat, chronic bronchitis, metal-inflicted wound, ulcer.
Lophatherum gracile, nature and flavor：It is sweet in flavor, light, it is cold in nature.Channel tropism：The thoughts of returning home, lung, stomach, bladder warp.Effect：Clearing heat-fire, relieving restlessness, profit
Urine.It cures mainly：For pyreticosis polydipsia, aphtha urinates red, puckery pain of heat gonorrhea.
Chinese gall, nature and flavor：It is sour, puckery, it is cold in nature.Channel tropism：Return lung, large intestine, kidney channel.Effect：It astringes the lung fall fire, relieving diarrhea with astringents,
Arrest sweating, hemostasis, hygroscopic sore.It cures mainly：For chronic cough of deficiency lung, lung feverish cough, protracted dysentery and diarrhea, spontaneous sweating quenches one's thirst, hemorrhoid of having blood in stool
Blood, traumatic hemorrhage, carbuncle sore tumefacting virus, skin moisture fester.
The bark of ash, nature and flavor：It is bitter, puckery, it is cold in nature.Channel tropism：Return liver, courage, large intestine channel.Effect：Heat-clearing and damp-drying drug, inducing astrigency stop dysentery, only
Band, improving eyesight.It cures mainly：Damp-heat dysentery, leukorrhea with reddish discharge, red eye, swell pain, raw screen film of mesh.
Radix Glycyrrhizae：It is mild-natured, sweet in flavor, return 12 warps.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviation drug poison
Property, it is strong have removing toxic substances, eliminating the phlegm, analgesic, spasmolysis so that the pharmacological actions such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
The fruit of glossy privet, meridian distribution of property and flavor：Sweet, bitter, cold.Return liver and kidney channel.Effect：It tonifies the liver and kidney, improving eyesight, clearind deficient heat.It cures mainly：Head
Dizzy dizzy, poliosis, blurring of vision, fever due to yin deficiency.
Rhizoma Atractylodis Macrocephalae, meridian distribution of property and flavor：Bitter, it is sweet, it is warm-natured.Returns spleen, stomach.Major function：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis,
Tocolysis.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.Rhizoma Atractylodis Macrocephalae invigorating the spleen and stomach, tocolysis.
For spleen eating less, diarrhea loose stool, fetal irritability.
Thizoma curculiginis, major function：Warm kidney sun is strong；Dispel cold-dampness.Main impotence cold sperm；Aconuresis；Coldness and pain in the epigastrium；Waist and knee acid
Bitterly；Muscles and bones is weak；Lower limb contraction.
Hyacinth bean, meridian distribution of property and flavor：Sweet and neutral.Channel tropism：Enter spleen, stomach.Be conducive to dispelling for summer-heat and damp perverse trend, the benefits of invigorating the spleen to arrest diarrhea,
Hyacinth bean also has the effect of significant regressing tumors simultaneously.
Madder, cooling and activating blood, dissolving stasis, promoting menstruation.For spitting blood, bleeding from five sense organs or subcutaneous tissue, metrostaxis, traumatic hemorrhage, Amenorrhea stasis blocking, joint
Numbness pain, tumbling and swelling.Cooling blood and hemostasis, promoting blood circulation.With antibechic method phlegm, antibacterial action.
The compound of glauber-salt and liquorice, meridian distribution of property and flavor：Xin Xian；It is cold；It is nontoxic.Channel tropism：Stomach；The heart；Lung；Large intestine channel.With purgating heat and bowels；Softening hard masses dissipate
Knot；It is clearing heat and detoxicating；Clearing lung-heat relieving summer-heat；The effect of disperse accumulation and stomach.Primary treatment real heat stagnates；Constipation；Red eye, swell pain；Pharynx swelling mouth
Sore；Swollen ulcer drug.
Dianthus superbus, nature and flavor：Bitter, it is cold in nature.Channel tropism：The thoughts of returning home, small intestinl channel.Function：There is the effect of inducing diuresis for treating strangurtia, invigorate blood circulation.
It cures mainly：For heat gonorrhea, blood strangury, urolithiasis, urinary obstruction, the puckery pain of leaching drip, Amenorrhea stasis of blood the moon.
Rush, nature and flavor：It is sweet in flavor, light, cold nature.Channel tropism：The thoughts of returning home, lung, small intestinl channel.Effect：Clearing away the heart-fire, diuresis.It is main
It controls：For vexed insomnia, the puckery pain of oliguria, aphthae.
Rhizoma menispermi, nature and flavor：Bitter, it is cold in nature.Channel tropism：Return lung, stomach, large intestine channel.Effect：It is clearing heat and detoxicating, wind-expelling pain-stopping.It is main
It controls：For abscess of throat, heat toxin rush down dysentery, arthralgia pain due to rheumatism.
Wilsonii, antibacterial and anti-inflammation functions：Wilsonii can mitigate hot the mouse of adrenalectomize in summer, autumn and winter
Inflammatory oedema, in spring slightly antiinflammation.To the rat of adrenalectomize, formaldehyde joint can be prevented in winter and spring
The development of inflammation.Inflammation caused by physiological saline and 15% protein solution can be mitigated.The mouse and rabbit infected with Listera spp
After injecting siberian Ginseng P.E, first hour is reduction of the resistance of animals against infection, then significantly enhances to sense
The resistance of dye, it is believed that it is improved the ability of body enteric bacilli.
The beneficial effects of the invention are as follows：Probiotics in the present invention, without antagonism between three bacterial strains, between each other
Synergistic effect, with reference to Chinese medicine preparation, be of the invention there is stronger specific aim and effective when treat chickens respiratory disease
Property provides nutrition for broiler chicken, improves food conversion ratio, promotes growth of meat chicken, strengthen immunity；Component in inventive formulation is equal
For pure natural raw material, without any chemical classes drug；Active ingredient containing multiple beneficial broiler chicken respiratory apparatus health care, Fang Zhongxuan
Bright powder, pig's bile have clearing heat and detoxicating, cough and asthma relieving efficacy, and thizoma curculiginis, hyacinth bean, Schisandra chinensis have enhancing cellular immune function, alizarin
Grass, dianthus superbus, rush, Fructus Forsythiae can be covered in the mucosa of inflammation after Radix Glycyrrhizae feeding to playing an important role of anti-bacteria and anti-virus,
Promote the secretion of pharyngeal and tunica mucosa bronchiorum, phlegm is made to be easy to expectoration, mitigate inflammatory stimulus, be presented the effect of eliminating phlegm and relieving cough, rhizoma menispermi,
Lophatherum gracile, the bark of ash have treatment abscess of throat, the effect of heat toxin rush down dysentery, and Rhizoma Atractylodis Macrocephalae, the fruit of glossy privet have the development of enhancing immune organ, extensively
Radix Aucklandiae, stone reed have anti-stress effect with promoting qi circulation and relieving pain, the detumescence of doctor's sore, with antibacterial action, wilsonii and vitamin A, always
This formula compatibility it is reasonable, mutually synergistic effect plays clearing heat and detoxicating, antiviral, resisting stress, prevention shortness of breath, cough, asthma etc.
Effect；The probability that chicken group's breathing problem occurs, enhancing chicken premunition and raising chicken survival rate can be effectively reduced, is protected
Demonstrate,prove the normal growth and development of chicken group, suitable for 1~20 age in days broiler chicken use, production cost is low, production and using it is simple, use
It is with obvious effects, have no adverse reaction, have many advantages, such as promote and apply.
Specific embodiment
Embodiment 1
A kind of composite drug for preventing chickens respiratory disease, is made of the component of following parts by weight：
99.94 parts of 0.03 part of probiotics, 0.03 part of vitamin A and Chinese medicine additive；
The probiotics includes lactic acid bacteria, bacillus and hay bacillus, the lactic acid bacteria, bacillus and withered grass bar
The quantity ratio (cfu) of bacterium is：40：30：30, the wherein probiotics is 5 × 10 containing viable count12cfu/g。
The Chinese medicine additive includes the bulk pharmaceutical chemicals of following parts by weight：45 parts of Fructus Forsythiae, 8 parts of pig's bile, 6 parts of costus root, stone reed
35 parts, 42 parts of lophatherum gracile, 6 parts of Chinese gall, 15 parts of the bark of ash, 50 parts of Radix Glycyrrhizae, 28 parts of the fruit of glossy privet, 22 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of thizoma curculiginis, hyacinth bean
30 parts, 35 parts of madder, 22 parts of the compound of glauber-salt and liquorice, 20 parts of dianthus superbus, 40 parts of rush, 30 parts of rhizoma menispermi, 6 parts of wilsonii.
The preparation method of the composite drug of the prevention chickens respiratory disease, by each component of Chinese medicine additive it is dry,
It is crushed after mixing, crosses 60 mesh sieves to get Chinese medicine additive；Then each component and the vitamin A of probiotics are added in get anti-
Control the composite drug of chickens respiratory disease.
Embodiment 2
A kind of composite drug for preventing chickens respiratory disease, is made of the component of following parts by weight：
99.95 parts of 0.02 part of probiotics, 0.03 part of vitamin A and Chinese medicine additive；
The probiotics includes lactic acid bacteria, bacillus and hay bacillus, the lactic acid bacteria, bacillus and withered grass bar
The quantity ratio (cfu) of bacterium is：45：30：25, the wherein probiotics is 4 × 10 containing viable count12cfu/g。
The Chinese medicine additive includes the bulk pharmaceutical chemicals of following parts by weight：40 parts of Fructus Forsythiae, 10 parts of pig's bile, 5 parts of costus root, stone reed
35 parts, 45 parts of lophatherum gracile, 5 parts of Chinese gall, 12 parts of the bark of ash, 60 parts of Radix Glycyrrhizae, 20 parts of the fruit of glossy privet, 25 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of thizoma curculiginis, hyacinth bean
25 parts, 40 parts of madder, 20 parts of the compound of glauber-salt and liquorice, 23 parts of dianthus superbus, 32 parts of rush, 28 parts of rhizoma menispermi, 10 parts of wilsonii.
The preparation method of the composite drug of the prevention chickens respiratory disease, by each component of Chinese medicine additive it is dry,
It is crushed after mixing, crosses 80 mesh sieves to get Chinese medicine additive；Then each component and the vitamin A of probiotics are added in get anti-
Control the composite drug of chickens respiratory disease.
Embodiment 3
A kind of composite drug for preventing chickens respiratory disease, is made of the component of following parts by weight：
99.92 parts of 0.04 part of probiotics, 0.04 part of vitamin A and Chinese medicine additive；
The probiotics includes lactic acid bacteria, bacillus and hay bacillus, the lactic acid bacteria, bacillus and withered grass bar
The quantity ratio (cfu) of bacterium is：40：35：25, the wherein probiotics is 7 × 10 containing viable count12cfu/g。
The Chinese medicine additive includes the bulk pharmaceutical chemicals of following parts by weight：42 parts of Fructus Forsythiae, 6 parts of pig's bile, 5 parts of costus root, stone reed
40 parts, 38 parts of lophatherum gracile, 5 parts of Chinese gall, 12 parts of the bark of ash, 55 parts of Radix Glycyrrhizae, 25 parts of the fruit of glossy privet, 22 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of thizoma curculiginis, hyacinth bean
35 parts, 30 parts of madder, 25 parts of the compound of glauber-salt and liquorice, 22 parts of dianthus superbus, 38 parts of rush, 35 parts of rhizoma menispermi, 8 parts of wilsonii.
The preparation method of the composite drug of the prevention chickens respiratory disease, by each component of Chinese medicine additive it is dry,
It is crushed after mixing, crosses 100 mesh sieves to get Chinese medicine additive；Then add in probiotics each component and vitamin A to get
Prevent the composite drug of chickens respiratory disease.
Toxicity test：
SD rats are selected, give the composite medicine of the embodiment of the present invention 1 of various concentration (18.0,6.0,2.0g crude drugs/kg)
The decoction of agent, daily gavage once, continuous 90 days, after the last administration 24 it is small when each group work kill 1/2 animal (half male and half female), remaining
1/2 animal is living after continuing observation 2 weeks to be killed.Appearance, general behavior, food ration, the changes of weight of animal, administration are observed during experiment
Afterwards 90 days and be discontinued 2 weeks progress hematologies (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST,
ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the inspection of the indexs such as Histopathology
It looks into.Result of the test shows：The composite drug of the present invention is good in high, medium and low dosage group animal general state, appearance sign, row
For activity, food-intake and body weight increase variation without exception；Three dosage groups and control group hematological examination, blood biochemical analysis,
Urine biochemical analysis is without significant difference between normal range (NR), group；Each group main organs histopathological examination has no apparent different
Often.These parameters also have no change after being discontinued 2 weeks.This experiment dosage is respectively the 180 of clinical medicine dose, 60,20 times,
It is even given within 90 days in high, medium and low three dosage (18.0,6.0,2.0g crude drugs/kg) according to the composite drug of the result of the test present invention
Medicine has no significant effect rat, and without specific toxicity target organ and sensitive indicator, convalescence observation also has no that retardance toxicity is anti-
Should, the dose safety for prompting the composite drug clinical practice of the present invention is higher.
Clinical test 1：
In Liaocheng, farm chooses 1000 healthy, approximate 1 Day-old Broiler Chickens of weight, is randomly divided into two groups, every group
500, it is divided into control group and experimental group, the composite drug of the experimental group feeding embodiment of the present invention 1, control group feeding fowl race must be happy
(Chinese medicine materials such as Chinese ephedra, semen armeniacae amarae, gypsum, Radix Glycyrrhizae, campanulaceae are made, commercially available), after continuously feeding 20, two groups of growth of meat chicken shapes
Condition such as following table：As can be seen from the table, after continuous feeding feed provided by the invention, breathing problem occurs experimental group broiler chicken
Likelihood ratio control group chicken group reduce, chicken all living creatures's long status is good, and feed is active.
Broiler chicken application method：In growth of meat chicken 1-20 days, fed with the ratio spice of mass percent 1%.I.e. per 100kg
Feed adds 1kg composite drugs of the present invention, and feed additive amount is conventional additive amount, to prevent feed and environment to viable bacteria activity
Adverse effect, in proportion same day preparation, the free choice feeding same day have fed.
Result of the test is as shown in table 1, and result of the test shows：1st, breathing problem incidence, test group is significantly lower than control
Group.2nd, 20 age in days weight：Test group is apparently higher than control group.
The treatment results of 1 present invention of table and control group
| Group class | Experimental group | Control group |
| Breathing problem incidence | 0.2% | 4% |
| 20 age in days weight (g) | 523 | 456 |
Clinical test 2：
Experiment on therapy
300 5~8 ages in days of diseased chicken of natural infection infectious laryngotracheitis of chicken, are divided into three groups for the treatment of group A, control group, control
Treatment group is applied the composite drug of example 1 by daily every feeding, 2 times a day；Control group feeding fowl race must find pleasure in 2 times a day, treatment phase 5
My god, then observe 9 days, afterwards whole dissects.
Clinical efficacy criterion：Diseased chicken spirit, appetite recover normal after treatment, the symptoms such as shed tears, have a running nose, sneezing
It completely disappears, dissect atypism pathological change, for recovery from illness, calculates cure rate.In therapeutic process, because infection is dead, experiment knot
Though not dead but the still visible larynx of dissect and tracheae have bleeding, the pathological change of exudation during beam, it is invalid to be calculated as treatment, according to invalid
Number accounts for the total ratio for the treatment of and calculates inefficiency.
Table 2 treats natural infection infectious bronchitis chicken situation
From table 2 it can be seen that natural infection chicken is with the diseases such as in composite drug therapeutic process of the present invention, have a running nose, shed tears
Shape gradually mitigates or disappears；Spirit, feeding, drinking-water gradually recover normal or normal；Appetite is remarkably reinforced, and excrement also switchs to
Normally.The 15th day after to medication, all illness chicken substantially all healings, cure rate up to 98.67%, weight also gradually on
It rises.It is proved by therapeutic test, composite drug of the present invention has the effect of fine to infectious bronchitis of chicken.
Claims (5)
1. a kind of composite drug for preventing chickens respiratory disease, it is characterized in that, it is made of the component of following parts by weight：Micro- life
99.92 ~ 99.96 parts of 0.02 ~ 0.04 part of state preparation, 0.02 ~ 0.04 part of vitamin A and Chinese medicine additive；
The probiotics is made of following raw material：Lactic acid bacteria, bacillus and hay bacillus, the lactic acid bacteria, bacillus
Quantity ratio with hay bacillus is：30~50：20~35：25 ~ 35, the wherein probiotics is 10 containing viable count12~8×
1012cfu/g；
The Chinese medicine additive is made of the bulk pharmaceutical chemicals of following parts by weight：40 ~ 50 parts of Fructus Forsythiae, 5 ~ 15 parts of pig's bile, costus root 5 ~ 10
Part, 30 ~ 40 parts of stone reed, 30 ~ 45 parts of lophatherum gracile, 5 ~ 10 parts of Chinese gall, 10 ~ 20 parts of the bark of ash, 30 ~ 60 parts of Radix Glycyrrhizae, the fruit of glossy privet 20 ~ 30
Part, 20 ~ 25 parts of Rhizoma Atractylodis Macrocephalae, 5 ~ 8 parts of thizoma curculiginis, 25 ~ 35 parts of hyacinth bean, 30 ~ 40 parts of madder, 20 ~ 25 parts of the compound of glauber-salt and liquorice, 15 ~ 25 parts of dianthus superbus, lamp
30 ~ 45 parts of core grass, 25 ~ 35 parts of rhizoma menispermi, 5 ~ 15 parts of wilsonii.
2. the composite drug of prevention chickens respiratory disease as described in claim 1, it is characterized in that, it is by following parts by weight
Component forms：99.94 parts of 0.03 part of probiotics, 0.03 part of vitamin A and Chinese medicine additive；
The quantity ratio of the lactic acid bacteria, bacillus and hay bacillus is：40：30：30, the wherein probiotics contains viable count
For 5 × 1012cfu/g；
The Chinese medicine additive is made of the bulk pharmaceutical chemicals of following parts by weight：45 ~ 50 parts of Fructus Forsythiae, 5 ~ 8 parts of pig's bile, 5 ~ 8 parts of costus root,
35 ~ 38 parts of stone reed, 40 ~ 45 parts of lophatherum gracile, 5 ~ 8 parts of Chinese gall, 10 ~ 15 parts of the bark of ash, 45 ~ 55 parts of Radix Glycyrrhizae, 25 ~ 30 parts of the fruit of glossy privet,
20 ~ 25 parts of Rhizoma Atractylodis Macrocephalae, 5 ~ 6 parts of thizoma curculiginis, 30 ~ 35 parts of hyacinth bean, 32 ~ 38 parts of madder, 22 ~ 23 parts of the compound of glauber-salt and liquorice, 20 ~ 25 parts of dianthus superbus, wick
35 ~ 45 parts of grass, 30 ~ 35 parts of rhizoma menispermi, 5 ~ 10 parts of wilsonii.
3. as claimed in claim 2 prevention chickens respiratory disease composite drug, it is characterized in that, the Chinese medicine additive by
The bulk pharmaceutical chemicals composition of following parts by weight：45 parts of Fructus Forsythiae, 8 parts of pig's bile, 6 parts of costus root, 35 parts of stone reed, 42 parts, five times of lophatherum gracile
6 parts of son, 15 parts of the bark of ash, 50 parts of Radix Glycyrrhizae, 28 parts of the fruit of glossy privet, 22 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of thizoma curculiginis, 30 parts of hyacinth bean, 35 parts of madder, the compound of glauber-salt and liquorice
22 parts, 20 parts of dianthus superbus, 40 parts of rush, 30 parts of rhizoma menispermi, 6 parts of wilsonii.
4. the composite drug of chickens respiratory disease is prevented as described in claims 1 to 3 is any, it is characterized in that, the composite medicine
The dosage form of agent is pulvis.
5. the preparation method of the composite drug of any prevention chickens respiratory disease of claim 1 ~ 4, it is characterized in that：Step
For：It will be crushed after each component drying of Chinese medicine additive, mixing, cross 60~100 mesh sieves to get Chinese medicine additive；Then
Each component and the vitamin A of probiotics are added in get the composite drug of prevention chickens respiratory disease.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552657A (en) * | 2012-02-06 | 2012-07-11 | 青岛农业大学 | Chinese medicinal composition used for treating Newcastle disease of chicken |
| CN102835567A (en) * | 2011-06-21 | 2012-12-26 | 天津佳瑞兴科技发展有限公司 | Traditional Chinese medicine-containing feed premix for preventing respiratory disease |
| CN102908577A (en) * | 2011-08-06 | 2013-02-06 | 李红彬 | Chinese and western compound medicine for treating respiratory system infection |
| CN103392669A (en) * | 2013-07-26 | 2013-11-20 | 四川农业大学 | Method for feeding high-quality cocks by probiotics and traditional Chinese medicine and utilized feed |
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2015
- 2015-03-13 CN CN201510111361.8A patent/CN104707008B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102835567A (en) * | 2011-06-21 | 2012-12-26 | 天津佳瑞兴科技发展有限公司 | Traditional Chinese medicine-containing feed premix for preventing respiratory disease |
| CN102908577A (en) * | 2011-08-06 | 2013-02-06 | 李红彬 | Chinese and western compound medicine for treating respiratory system infection |
| CN102552657A (en) * | 2012-02-06 | 2012-07-11 | 青岛农业大学 | Chinese medicinal composition used for treating Newcastle disease of chicken |
| CN103392669A (en) * | 2013-07-26 | 2013-11-20 | 四川农业大学 | Method for feeding high-quality cocks by probiotics and traditional Chinese medicine and utilized feed |
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