CN104547186A - Compound fermented type traditional Chinese medicine for preventing and treating fowl cholera and preparation method of compound fermented type traditional Chinese medicine - Google Patents
Compound fermented type traditional Chinese medicine for preventing and treating fowl cholera and preparation method of compound fermented type traditional Chinese medicine Download PDFInfo
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Abstract
The invention relates to a compound fermented type traditional Chinese medicine for preventing and treating fowl cholera and a preparation method of the compound fermented type traditional Chinese medicine. The compound fermented type traditional Chinese medicine is prepared from the following traditional Chinese medicines in parts by weight: 27-30 parts of rhizoma coptidis, 30-33 parts of phellodendron, 18-20 parts of Chinese rhubarb, 35-40 parts of honeysuckle, 23-25 parts of radix isatidis, 4-6 parts of realgar, 18-20 parts of forsythia suspensa, 22-25 parts of herba artemisiae scopariae, 4-6 parts of agastache rugosa, 30-35 parts of dandelions, 20-23 parts of herba scutellariae barbatae and 10-12 parts of radix glycyrrhizae. The preparation method comprises the following steps: step 1, weighing the traditional Chinese medicines, crushing the weighed traditional Chinese medicines, and then screening the crushed traditional Chinese medicines with a sieve for processing; step 2, mixing all the components processed in the step 1, then adding composite bacterium liquid to the mixed components, mixing, fermenting and cooling the mixed components and the added composite bacterium liquid on a culture medium, finally adding a stabilizing agent, mixing the mixed components, the composite bacterium liquid and the stabilizing agent, and storing the mixture for standby application. The compound fermented type traditional Chinese medicine disclosed by the invention has the effects of dispelling wind, clearing heat, cooling blood for removing toxicity, diminishing inflammation, strengthening the heart, relieving the asthma and improving the immunity of organisms, mainly treats anemofrigid cold and swelling and pain in throat, is used for treating pyogenic infection and inflammation, leukopenia, cough and pant, white scour of piglets and the like, and can also be used as an auxiliary antitumor medicine; the compound fermented type traditional Chinese medicine can effectively prevent and treat the fowl cholera caused by pasteurella, and has the efficacies of dispelling heat to loosen the bowels, reducing the swelling for eliminating stagnation and cooling blood for hemostasis.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, be specifically related to a kind of for compound fermentation type Chinese medicine preventing, treat fowl cholera and preparation method thereof.
Background technology
Fowl cholera is a kind of contact disease of encroaching on poultry and wild fowl, has another name called fowl pasteurellosis, fowl hueppe's disease.Although fowl cholera little pandemic; but along with scale, the intensive development of modern poultry husbandry; due to the change of environment, weather; feeding and management, stressors, feed quality decline and the generation that the many reasons such as infectiousness epidemic disease, hypoimmunity all can cause fowl cholera occur; main in chronic type, show as: with chronic pneumonia, chronic respiratory is scorching and chronic gastroenteritis is more common.Sick chicken nostril toughness secretions flows out, nasal sinuses enlargement, and larynx is long-pending to be had secretions and affect breathing.Frequent diarrhoea.Sick chicken becomes thin, and down in spirits, is preced with pale.The remarkable enlargement of some sick chicken one or both sides wattle, may have purulence caseous substance subsequently, or dry and hard, downright bad, come off.The sick chicken had has arthritis, is often confined to foot or wing joint and stndon sheath place, and show as arthroncus, pain, toe paralysis, thus walk lamely, morbidity growth and development of chickens stops and laying eggs can not recovering for a long time.This technology is intended to prevention and therapy fowl cholera.
Chinese veterinarian's disease therapy is resist exopathogenic factor to invade by cultivating vigour in body the QI and blood change caused substantially, fundamentally can improve body constitution and promote rehabilitation.And modern age, doctor trained in Western medicine advocated solution disease for first, alleviated apparent.Positive so-called Western medicine bactericidal antiphlogistic is controlled " mark ", Chinese medicine enhancing body anti pathologic immunity function, is positive controlling " basis ".Chinese medicine is natural green medicine, and not easily cause receptor drug resistance and sequela, noresidue ensures food safety.Improve absorbing of its effective ingredient by the fermentation of microbial ecological agent simultaneously.
Herbal medicine is common often uses Chinese powder medicine and oral liquid etc., and Composite fermentation type Chinese medicine is a kind of novel special dosage form on veterinary drug.Modern herbal medicine theory is pointed out, a herb has nearly more than 300 plants active ingredient, usually can not play its due effect completely, can only do some make up by escalated dose, cause and utilize herbal medicine disease therapy high cost.The physiological characteristics intestinal of birds is short and small in addition, and content excreted at 3-4 hour, and make absorption not thorough, trap only has about 30%.And fermented type Chinese medicine is almost all absorbed in section at this moment.Composite fermentation Chinese medicinal ointment be Chinese herbal medicine through ultrasonic grinding, then add compound bacteria-fermented and form, the efficient composition such as albumen, tannin, starch in not removed Chinese herbal medicine, and these compositions play vital effect in treatment of diseases.Be converted into the composition that body is convenient to absorb with microbial action simultaneously, accelerate health care and treatment speed, improve health-care effect and curative effect, improve the microecological environment of body, improve animal spontaneous recovery and resistance against diseases, improve animal feed rate of returns and fertility performance.As can be seen here, compound fermentation Chinese medicine is greatly be better than other form of Chinese drug on pharmacological effect. from traditional Chinese veterinary medicine angle analysis, " exogenous pathogen mutual aid " is numerous disease predisposing factors, and when the five internal organs that namely traditional Chinese medical science is said are in " void ", virus is taken advantage of a weak point, and causes pathogen being excessive but vital QI weak, disease-resistant unable; Many because of the damp and hot fire-transformation of diseases caused by exogenous pathogenic factor, cause inhibited pulmonary QI, abnormal ascending-descending of QI, imbalance of YIN and YANG.Chinese herbal medicine can YIN and YANG balance regulating, treating both the principal and secondary aspects of a disease, make body constitutionally, immunity is thought and acted in one and the same way, equilibrium between yin and yang, thus reach the ideal cultivation state of " ill to send out less, morbidity die less ".
Summary of the invention
Object of the present invention is just to overcome the deficiencies in the prior art, there is provided a kind of disease can treated body microbial state treatment and cause fowl cholera and other virus of secondary and bacteria mixed infection, namely for compound fermentation type Chinese medicine preventing, treat fowl cholera and preparation method thereof.
For achieving the above object, the present invention is by the following technical solutions:
For preventing, treating a compound fermentation type Chinese medicine for fowl cholera, formed by the Chinese drug preparation of following weight parts: Rhizoma Coptidis 27-30, Cortex Phellodendri 30-33, Radix Et Rhizoma Rhei 18-20, Flos Lonicerae 35-40, Radix Isatidis 23-25, Realgar 4-6, Fructus Forsythiae 18-20, Herba Artemisiae Scopariae 22-25, Herba Pogostemonis 4-6, Herba Taraxaci 30-35, Herba Scutellariae Barbatae 20-23, Radix Glycyrrhizae 10-12.
For preventing, treating a preparation method for the compound fermentation type Chinese medicine of fowl cholera, comprise the steps:
Step one, takes by weight by each for Chinese medicine composition, adopts ultrasonic grinding and cell wall wall breaking technology to pulverize respectively, then crosses 20-80 object sieve and carries out preliminary treatment;
Step 2, each composition step one handled well mixes, and then adds the composite bacteria liquid that weight portion is 2-3, at the culture medium top fermentation 16-18 hour of 35-37 DEG C, adds stabilizing agent mixing and save backup after being cooled to 20-25 DEG C.
The each composition of culture medium in described step 2 is the mass percent of each composition sum of Chinese medicine: wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
Stabilizing agent in described step 2 is the mass percent of each composition of Chinese medicine, each composition of culture medium, each composition sum of composite bacteria liquid: preservative sodium benzoate 0.05-0.08% and antioxidant propyl gallate 0.008-0.01%.
In described step 2, extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation as strain to the concrete preparation method of composite bacteria liquid: a. respectively respectively, is added to increase in bacterium cultured solution of broth after the bacterium colony normal saline eluting that often kind of slant culture is produced and make suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only; B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 2:(1-2): 1:1 ratio is mixed to get composite bacteria liquid.
The pharmacological action of Chinese medicine of the present invention is as follows:
Rhizoma Coptidis: bitter cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.
Cortex Phellodendri: bitter cold.Return kidney, bladder, large intestine channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.
Radix Et Rhizoma Rhei: bitter cold.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass clots absorbing stimulates the menstrual flow.
Flos Lonicerae: Gan Han.Enter lung, the heart, stomach warp.Heat-clearing and toxic substances removing, heat radiation dispelling wind.
Radix Isatidis: bitter cold.GUIXIN, stomach warp, heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.
Realgar: pungent, temperature; Poisonous.Return liver, large intestine channel.Removing toxic substances parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria.
Fructus Forsythiae: bitter cool.Enter the heart, liver, gallbladder meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis, jaundice eliminating.
Herba Pogostemonis: pungent, tepor.Return spleen, stomach, lung meridian.Eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.
Herba Taraxaci: bitter sweet, cold.Enter liver, stomach warp.Heat-clearing and toxic substances removing, diuresis eliminating stagnation
Herba Scutellariae Barbatae: pungent, flat.Return lung, the heart, gallbladder meridian.There is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect.
Fructus Forsythiae: nature and flavor are bitter, cool.Enter the heart, liver, gallbladder meridian.Heat clearing away, removing toxic substances, eliminating stagnation, detumescence.
Radix Glycyrrhizae: Gan Ping.Invigorating the spleen and replenishing QI, and middle emergency, coordinating the actions of various ingredients in a prescription, altogether for making medicine.
Cortex Phellodendri, Rhizoma Coptidis, Radix Et Rhizoma Rhei are monarch drug, and three tastes share, heat clearing and damp drying, removing mass clots absorbing, Synergistic; Wherein contained berberine, soap class, glycoside, flavones ingredient have anti-multiple pathogenic microorganisms effect, especially have better effect to pasteurellosis bacillus; Herba Artemisiae Scopariae, Herba Taraxaci, Herba Scutellariae Barbatae are adjuvant drug, bitter cold, heat clearing away eliminating stagnation, Huayu Tonglin.Flos Lonicerae, Radix Isatidis, Fructus Forsythiae are ministerial drug, the same use of three medicines, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Therefore, full side demonstrates can the effective fowl cholera that causes of prevention and therapy pasteurellosis bacillus, has effect of purging heat to relax the bowels, dispersing swelling and dissipating binds, cooling blood for hemostasis.Invention enhances the function that body regulates, effectively can alleviate intestinal diarrhoea, septicemia, eliminate or obviously alleviate the inflammatory pathology damage of the histoorgans such as intestinal, alleviate the potential safety hazard that chemical medicine causes, add the safety of medication.
Positive beneficial effect of the present invention:
(1) the present invention's science of being carried out by various Chinese medicine reasonable compatibility is extracted and is used, and plays the complementary action of different mechanism of action, thus plays the effect of stronger antibacterial, antiviral, raising immunity.
(2) ultrasonic grinding and cell wall wall breaking technology is adopted, and microbial fermentation technology, effective ingredient is not destroyed, and ensure that effective ingredient is sufficient, drug effect increases.
(3) the present invention has wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body, antiinflammatory, heart tonifying, relievings asthma, improves immunity of organisms effect, cures mainly anemofrigid cold, laryngopharynx swelling and pain, for pyogenic infection and inflammation, leukopenia, cough, piglet pujos blancos etc.; Also can be used as used as adjuvant drug for antitumor.This programme can the effective fowl cholera that causes of prevention and therapy pasteurellosis bacillus, has effect of purging heat to relax the bowels, dispersing swelling and dissipating binds, cooling blood for hemostasis.Invention enhances the function that body regulates, effectively can alleviate intestinal diarrhoea, septicemia, eliminate or obviously alleviate the inflammatory pathology damage of the histoorgans such as intestinal, alleviate the potential safety hazard that chemical medicine causes, add the safety of medication.
Detailed description of the invention
In embodiments of the invention, the concrete preparation method of composite bacteria liquid is as follows: a. respectively extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carries out slant strains cultivation respectively as strain, is added to increase in bacterium cultured solution of broth after the bacterium colony normal saline eluting that often kind of slant culture is produced and make suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only; B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 2:(1-2): 1:1 ratio is mixed to get composite bacteria liquid.
Embodiment 1
For preventing, treating the compound fermentation type Chinese medicine of fowl cholera, formed by the Chinese drug preparation of following weight parts: Rhizoma Coptidis 27-30, Cortex Phellodendri 30-33, Radix Et Rhizoma Rhei 18-20, Flos Lonicerae 35-40, Radix Isatidis 23-25, Realgar 4-6, Fructus Forsythiae 18-20, Herba Artemisiae Scopariae 22-25, Herba Pogostemonis 4-6, Herba Taraxaci 30-35, Herba Scutellariae Barbatae 20-23, Radix Glycyrrhizae 10-12.
For preventing, treating the preparation method of the compound fermentation type Chinese medicine of fowl cholera, comprise the steps:
Step one, takes by weight by each for Chinese medicine composition, adopts ultrasonic grinding and cell wall wall breaking technology to pulverize respectively, then crosses 20-80 object sieve and carries out preliminary treatment;
Step 2, each composition step one handled well mixes, and then adds the composite bacteria liquid that weight portion is 2-3, at the culture medium top fermentation 16-18 hour of 35-37 DEG C, adds stabilizing agent mixing and save backup after being cooled to 20-25 DEG C.
The each composition of culture medium in described step 2 is the mass percent of each composition sum of Chinese medicine: wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
Stabilizing agent in described step 2 is the mass percent of each composition of Chinese medicine, each composition of culture medium, each composition sum of composite bacteria liquid: preservative sodium benzoate 0.05-0.08% and antioxidant propyl gallate 0.008-0.01%.
In described step 2, extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation as strain to the concrete preparation method of composite bacteria liquid: a. respectively respectively, is added to increase in bacterium cultured solution of broth after the bacterium colony normal saline eluting that often kind of slant culture is produced and make suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only; B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 2:(1-2): 1:1 ratio is mixed to get composite bacteria liquid.
Embodiment 2
For preventing, treating the compound fermentation type Chinese medicine of fowl cholera, formed by the Chinese drug preparation of following weight parts: Rhizoma Coptidis 30g, Cortex Phellodendri 30g, Radix Et Rhizoma Rhei 20g, Flos Lonicerae 40g, Radix Isatidis 20g, Realgar 5g, Fructus Forsythiae 20g, Herba Artemisiae Scopariae 20g, Herba Pogostemonis 5g, Herba Taraxaci 30g, Herba Scutellariae Barbatae 20g, Radix Glycyrrhizae 10g.
For preventing, treating the preparation method of the compound fermentation type Chinese medicine of fowl cholera, comprise the steps:
Step one, takes by weight by each for Chinese medicine composition, adopts ultrasonic grinding and cell wall wall breaking technology to pulverize respectively, then crosses 80 object sieves and carries out preliminary treatment;
Step 2, each composition step one handled well mixes, and then adds composite bacteria liquid 2g, the culture medium top fermentation 18 hours of 37 DEG C, adds stabilizing agent mixing and save backup after being cooled to 25 DEG C.
The each composition of culture medium in described step 2 is wheat bran 63g, bean cake 10g, ammonium sulfate 5g, magnesium sulfate 2g, calcium carbonate 2.5g and water 75g.
Preservative sodium benzoate 0.25g in described step 2 and antioxidant propyl gallate 0.05g.
In described step 2, extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation as strain to the concrete preparation method of composite bacteria liquid: a. respectively respectively, is added to increase in bacterium cultured solution of broth after the bacterium colony normal saline eluting that often kind of slant culture is produced and make suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.6 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only; B. obtained for step a lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid are mixed to get composite bacteria liquid according to 2:1:1:1 ratio, lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and bacillus liquid two be respectively 0.8g, 0.4g, 0.4g, 0.4g.
Embodiment 3
Concrete steps are as embodiment 2, and formula and preparation parameter are shown in Table 1 (temperature DEG C, quality g, time h):
this Chinese herbal medicine proves according to clinical trial
1, drug effect plays rapidly, and side effect is little, and treatment time is short, easy to use.
Concrete formula and preparation method are as described in Example 2, make an addition in feedstuff in the ratio of feedstuff 0.5%, throw something and feed from dispensing observation in latter 24 hours, mine massively appetite and spirit of chicken takes an evident turn for the better, after 48 hours, mortality rate declines to some extent, after 72 hours, feed intake and spirit recover normal substantially, and dissect the pathological changes incidence rate 85-95% lower than matched group of rear internal organs.Concrete outcome is as shown in table 2 below.
2, persistent period that plays a role is long, and blood drug level is high, lasting medicine.
Through than compared with normal Chinese herbal medicine digestive system stop 2-6 little time, and after this technical finesse, be 8-12 hour in the effective time of birds digestive system, substantially prolongs the time of staying in intestinal, absorption rate significantly increases, and through comparing, common Chinese (40-60 order) can detect a large amount of Chinese medicine prototypes after discharging with feces in intestinal, and this experiment product is after discharging through feces, almost can't check.MIC also obviously differs simultaneously, and this experiment product is higher than common Chinese by more than 95%.
3, with strong points, cure rate is high, and protective rate is high.
Throw and take this experiment product and throw the broiler taking common Chinese, after feeding 4 days, obviously occur difference, table 3 specific as follows:
the model case of Chinese medicine composition clinical efficacy:
The concrete formula that this model case uses and preparation method as described in Example 2, make an addition in feedstuff in the ratio of feedstuff 0.5-1%.
Example 1
Jiaozhuo, Henan plant 32 Japanese instar chickling, about 500 chickling morbidities, clinical disease chicken main manifestations is that spirit is depressed, and feather pine disorderly, close one's eyes by necking down, and head contracting, under wing, is reluctant to walk about, and peels off slow-witted vertical.Sick chicken often has diarrhoea, discharges the loose stool of yellow, canescence or green.Body temperature is elevated to 43 ~ 44 DEG C, subtracts food or does not eat, thirsty for increasing.Dyspnea, mouth, nasal discharge increase.Cockscomb and wattle paleness purple, the sick Carnis Gallus domesticus whisker swelling had, has burning pain sense.Laying hen stops laying eggs.Finally there is exhaustion, stupor and dead, pact half a day that the course of disease is short, grow 1 ~ 3d.It is hemorrhage that pathological changes shows the peritoneum of disease chicken, subcutaneous tissue and the common point of stomach fat.Pericardium is thickening, and pericardium inner product has the opaque weak yellow liquid of volume, the cotton-shaped liquid of some cellulose, and visceral pericardium, heart hat fat is hemorrhage particularly evident.Lung has hyperemia or petechia.The pathological changes of liver has characteristic, and liver is slightly swollen, and qualitative change is crisp, in brown or yellowish-brown.The downright bad point that liver surface distribution has many canescence, syringe needle large.Spleen generally loses significant change, or enlargement a little, and quality is more soft.Muscular stomach is significantly hemorrhage, and intestinal especially duodenum is Catarrhal and hemorrhagic enteritis, and intestinal contents contains blood.Be fowl cholera after diagnosing.Compound fermentation type Chinese medicine composition prepared by application the present invention is treated, and adopts the mode administration of spice administration, carries out strict sterilization process before and after treatment to colony house.Medication is after 3 days, and clinical symptoms and the mental status of sick chicken are clearly better, and medication is after 5 days, and 486 sick chickens get well, clinical symptom disappearance, and cure rate reaches 97.2%, cures and pays a return visit after one month, and the sick chicken of rehabilitation is not recurred again.And apply plain edition Chinese medicine composition prepared by the present invention and treat, adopt the mode administration of spice administration, before and after treatment, strict sterilization process is carried out to colony house.Medication is after 6 days, and clinical symptoms and the mental status of sick chicken are clearly better, and medication is after 10 days, and 451 sick chickens get well, clinical symptom disappearance, and cure rate reaches 90.2%, cures and pays a return visit after one month, and the sick chicken of rehabilitation is not recurred again.
Example 2
There is epidemic situation in certain body raiser laying hen, one 450, nasal sinuses enlargement appears that obvious sick chicken nostril toughness secretions flows out, in the laying hen of 280 ages in days, and larynx is long-pending to be had secretions and affect breathing.Frequent diarrhoea.Sick chicken becomes thin, and down in spirits, is preced with pale.The remarkable enlargement of some sick chicken one or both sides wattle, may have purulence caseous substance subsequently, or dry and hard, downright bad, come off.The sick chicken had has arthritis, is often confined to foot or wing joint and stndon sheath place, shows as arthroncus, pain, toe paralysis, thus walks lamely.The course of disease can be dragged to more than one month, but growth promoter can not recover for a long time with laying eggs.Cut open inspection to see in nose and paranasal sinuses and have volume viscous secretion, some case is shown in pneumonocirrhosis.Be confined to the case of arthritis and tenosynovitis, mainly see joint swelling deformation, have inflammatory exudate and caseous necrosis.The wattle enlargement of cock, inside has caseous exudate, and the ovary of hen is obviously hemorrhage, and follicle distortion sometimes, like partly boiling sample.Be fowl cholera after diagnosing.Compound fermentation type Chinese medicine composition prepared by application the present invention is treated, and adopts the mode administration of spice administration, carries out strict sterilization before and after treatment to hen house and surrounding.After 3 days, chicken is mined massively that appetite rises, egg drop reduction slows down in medication, and medication is after 5 days, and lay eggs and start to recover, shell egg recovers normal substantially, and through medication in 10 days, lay eggs and return to former 95%, cure rate reached 99.5%, and cure return visit in latter three months, rehabilitation chicken group does not fall ill again.And apply plain edition Chinese medicine composition prepared by the present invention and treat, adopt the mode administration of spice administration, before and after treatment, strict sterilization is carried out to hen house and surrounding.After 7 days, chicken is mined massively that appetite rises, egg drop reduction slows down in medication, and medication is after 10 days, and lay eggs and start to recover, shell egg recovers normal substantially, and through medication in 15 days, lay eggs and return to former 88%, cure rate reached 92.61%, and cure return visit in latter three months, rehabilitation chicken group does not fall ill again.
Claims (5)
1., for preventing, treating the compound fermentation type Chinese medicine of fowl cholera, it is characterized in that being formed by the Chinese drug preparation of following weight parts: Rhizoma Coptidis 27-30, Cortex Phellodendri 30-33, Radix Et Rhizoma Rhei 18-20, Flos Lonicerae 35-40, Radix Isatidis 23-25, Realgar 4-6, Fructus Forsythiae 18-20, Herba Artemisiae Scopariae 22-25, Herba Pogostemonis 4-6, Herba Taraxaci 30-35, Herba Scutellariae Barbatae 20-23, Radix Glycyrrhizae 10-12.
2. as claimed in claim 1 for preventing, treating the preparation method of the compound fermentation type Chinese medicine of fowl cholera, it is characterized in that comprising the steps:
Step one, takes by weight by each for Chinese medicine composition, adopts ultrasonic grinding and cell wall wall breaking technology to pulverize respectively, then crosses 20-80 object sieve and carries out preliminary treatment;
Step 2, each composition step one handled well mixes, and then adds the composite bacteria liquid that weight portion is 2-3, at the culture medium top fermentation 16-18 hour of 35-37 DEG C, adds stabilizing agent mixing and save backup after being cooled to 20-25 DEG C.
3. according to claim 2 for preventing, treating the preparation method of the compound fermentation type Chinese medicine of fowl cholera, it is characterized in that, each composition of the culture medium in described step 2 is the mass percent of each composition sum of Chinese medicine: wheat bran 20-30%, bean cake 3-4%, ammonium sulfate 1-2%, magnesium sulfate 0.5-1%, calcium carbonate 1-2% and water 20-30%.
4. according to claim 3 for preventing, treating the preparation method of the compound fermentation type Chinese medicine of fowl cholera, it is characterized in that, the stabilizing agent in described step 2 is the mass percent of each composition of Chinese medicine, each composition of culture medium, each composition sum of composite bacteria liquid: preservative sodium benzoate 0.05-0.08% and antioxidant propyl gallate 0.008-0.01%.
5. according to claim 4 for preventing, treating the preparation method of the compound fermentation type Chinese medicine of fowl cholera, it is characterized in that, in described step 2, extracting lactic acid bacterium, yeast, streptococcus faecalis and bacillus cereus carry out slant strains cultivation as strain to the concrete preparation method of composite bacteria liquid: a. respectively respectively, is added to increase in bacterium cultured solution of broth after the bacterium colony normal saline eluting that often kind of slant culture is produced and make suspension, and then amplification culture is distinguished in appropriate media, be cultured to exponential phase 0.5 × 10
8cFU/mL to 1.0 × 10
8during CFU/mL only; B. the lactobacillus suspension, yeast liquid, streptococcus faecalis liquid and the bacillus liquid that are obtained by step a are according to 2:(1-2): 1:1 ratio is mixed to get composite bacteria liquid.
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Cited By (3)
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| CN105902641A (en) * | 2016-04-18 | 2016-08-31 | 巫璐君 | Medicine for preventing chicken cholera |
| CN106074812A (en) * | 2016-08-29 | 2016-11-09 | 兴文县鸿程农业生态科技开发有限责任公司 | A kind of Chinese medicine compound for preventing and treating bacterial disease of fowl and application |
| CN106511565A (en) * | 2015-09-09 | 2017-03-22 | 谭慧敏 | Medicament for treating cholera of chicken fowls |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511565A (en) * | 2015-09-09 | 2017-03-22 | 谭慧敏 | Medicament for treating cholera of chicken fowls |
| CN105902641A (en) * | 2016-04-18 | 2016-08-31 | 巫璐君 | Medicine for preventing chicken cholera |
| CN106074812A (en) * | 2016-08-29 | 2016-11-09 | 兴文县鸿程农业生态科技开发有限责任公司 | A kind of Chinese medicine compound for preventing and treating bacterial disease of fowl and application |
| CN106074812B (en) * | 2016-08-29 | 2020-01-21 | 兴文县鸿程农业生态科技开发有限责任公司 | Traditional Chinese medicine compound for preventing and treating poultry bacterial diseases and application |
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Application publication date: 20150429 |