CN104706559B - A kind of special hand lotion of Automobile Service worker and preparation method thereof - Google Patents

Abstract

The invention relates to a special hand cream for auto repair workers and a preparation method thereof. The hand cream is composed of the following raw materials in parts by weight: beeswax, peony seed oil, corn germ oil, aloe vera gel, hyaluronic acid, Medicinal petrolatum, shea butter, and paraben. The present invention also provides a preparation method of hyaluronic acid, through which the production efficiency of hyaluronic acid can be increased. The invention has simple production process and low production cost. After mixing beeswax, peony seed oil, corn germ oil, aloe gel, hyaluronic acid and other substances, the invention can treat the hand injury caused by long-term use of washing powder and sawdust by auto repair workers. Dry, smelly problems have a better therapeutic effect.

Description

A kind of special hand cream for auto repair workers and preparation method thereof

technical field

The invention relates to a hand cream, in particular to a special hand cream for auto repair workers and a preparation method thereof, belonging to the field of daily necessities.

Background technique

Hyaluronic acid: also known as hyaluronic acid, is an acidic mucopolysaccharide. It is an important basic substance for skin suppleness, and it is also a component of the human body. It has a special moisturizing effect, and its weight is as high as 100 times its own weight. It is the best moisturizing substance in nature and is called ideal. natural moisturizing factor. It can improve skin nutrient metabolism, make skin soft, smooth, wrinkle-free, increase elasticity, and it is also a good transdermal absorption accelerator while moisturizing.

Peony seed oil: Peony seed oil is rich in VA, VE, nicotinic acid, carotene, and unsaturated fatty acids, which has an excellent nutritional care effect on the skin, can significantly improve the circulation function of skin epidermal cells, and promote the microvascularization of skin capillaries. Circulation effect, inhibit lipid peroxidation, improve metabolism, delay skin aging process, have anti-wrinkle, moisturizing and whitening effects, smooth and relaxed skin after use, and treat chloasma, skin aging wrinkles, skin keratin hardening and peeling, skin wrinkles Cracked, dry skin has a certain therapeutic effect.

Aloe vera gel: Delay skin aging. There is a unique protein in aloe vera gel, and this substance is an important component to prevent cell aging and chronic allergies. Aloe vera gel can activate cell vitality, delay skin aging, astringe and harmonize the skin. At the same time, the penetration of aloe vera gel can help the skin capture oxygen, lock in moisture, and balance skin water and oil. Added sodium hyaluronate, glucosaminoglycan and other ingredients are essential nutrients for the skin, have astringent effect, make the skin firm and delicate, prevent skin sagging, and effectively lock in moisture. Aloe vera is not only a moisturizing agent, whitening agent, and sunscreen for the skin, but also a nutrient and therapeutic agent for the hair. In addition, the cool aloe vera gel is also effective for moisturizing lips and sensitive skin. Known as "beauty gel".

Medical Vaseline: The taste of Vaseline itself is very light. It is very suitable for people who are allergic to the essence and alcohol added to moisturizing products. Secondly, petroleum jelly is not hydrophilic, so it can keep the skin moist when applied on the skin, keep the skin tissue at the wound site in the best condition, and accelerate the skin's own repair ability. In addition, petroleum jelly has no bactericidal ability, it just blocks the bacteria from the air and the skin contact, thereby reducing the possibility of infection.

Beeswax: Beeswax is a substance secreted by four pairs of wax glands under the abdomen of worker bees. Its main components are: acids, free fatty acids, free fatty alcohols and carbohydrates. In addition, there are carotenoids, vitamin A, aromatic substances and so on.

Shea butter: also known as shea butter, is a natural, non-toxic and non-irritating product. The crude shea butter obtained from the fruit pit is a gray, fatty substance, and the white or light yellow fat-packed shea butter is obtained during the refining process. Because the melting point of shea butter is consistent with the body temperature, it is a very suitable moisturizer, can be quickly absorbed by the skin, has analgesic and special sunscreen functions, has good compatibility with the skin, and can stimulate cells It grows, heals wounds, and has excellent curative effect on dry skin, dermatitis, skin diseases, eczema and other skin allergies. Shea butter has good moisturizing and emollient effects, and its high content of unsaponifiable lipids, especially triterpene cinnamate, helps skin heal and restore through anti-inflammatory effects.

It is difficult to clean the dirty oil on the hands of auto repair workers. They often use sawing wood and washing powder to clean it. Although the effect is good, washing powder is alkaline, and human skin is weakly acidic. It is recommended to use weak acid The surfactants, brighteners, and builders added to laundry detergent and washing powder will irritate the skin once they directly contact or adhere to the clothes, which will cause greater damage to the opponent. Professional hand sanitizers are more expensive, and auto repair Workers are often difficult to accept. So a kind of special-purpose hand cream that is suitable for auto repair workers urgently needs research and development.

Contents of the invention

In order to overcome the above problems, the invention provides a special hand cream for auto repair workers and a preparation method thereof, and the technical scheme of the invention is as follows:

A special hand cream for auto repair workers, consisting of the following raw materials in parts by weight:

Beeswax, Peony Seed Oil, Corn Germ Oil, Aloe Vera Gel, Hyaluronic Acid, Medical Petrolatum, Shea Butter, Nepal Gold Ester.

Preferably, 3-5 parts of beeswax, 2-3 parts of peony seed oil, 3-4 parts of corn germ oil, 15-25 parts of aloe vera gel, 15-25 parts of hyaluronic acid, 20-30 parts of medical vaseline, shea butter 3-5 parts, Nepal gold ester 0.1-0.2 parts.

More preferably, 3.5 parts of beeswax, 3 parts of peony seed oil, 3.2 parts of corn germ oil, 18 parts of aloe vera gel, 22 parts of hyaluronic acid, 22 parts of medical petroleum jelly, 3.3 parts of shea butter, and 0.14 parts of Nepal gold ester.

The preparation method of above-mentioned hyaluronic acid is as follows:

(1) Preparation of hyaluronic acid

Take the veterinary streptococcus on the slope and inoculate it into a 500mL Erlenmeyer flask containing 100mL of seed medium, put it into a shaker at 37°C, and cultivate it at a speed of 180 rpm for 20 hours, and inoculate it into a flask containing 7L of fermentation medium. In a 14L fermenter, the inoculum size is 10%, the fermentation condition is 37°C, the pH is 6.7-6.9, the ventilation rate is 2.4L/h, the stirring speed is 150 rpm, and the culture is 48 hours; the preferred pH is 6.7.

Seed medium (g/L): glucose 20.0, yeast extract 10.0, beef extract 10.0, MgSO ₄ 7H ₂ O 2.0, MnSO ₄ 4H ₂ O 0.1, KH ₂ PO ₄ 2.0, CaCO ₃ 20, trace element solution 1mL /L and buffer solution 40mL/L; among them, trace element solution: CaCl ₂ 2000mg/L, MnSO ₄ 4H ₂ O 24mg/L, ZnCl ₂ 46mg/L, CuSO ₄ 5H ₂ O 19mg/L; buffer solution: NaHPO ₄ 12H ₂ O 36.76g/L, NaH ₂ PO ₄ 12H ₂ O 15.98g/L, NaHCO ₃ 12.5g/L, adjust the pH to 6.8, and sterilize at 120°C for 15 minutes;

Fermentation medium (g/L): glucose 45.0, yeast extract 20.0, K ₂ SO ₄ 1.3, MgSO ₄ 7H ₂ O 2.0, Na ₂ HPO ₄ 12H ₂ O 6.2, FeSO ₄ 7H ₂ O 0.005, trace elements Solution 2.5mL/L, adjust the pH to 6.7, and sterilize at 120°C for 15min.

(2) Extraction of hyaluronic acid

Adopt ethanol precipitation method to obtain pure white powder which is hyaluronic acid.

The preparation method of special hand cream for auto repair workers of the present invention is as follows:

(1) Weigh beeswax, peony seed oil, corn germ oil, shea butter and Nepal gold ester in parts by weight, put them into a stirring tank and stir evenly to obtain mixture A, and heat mixture A in a water bath to 65-69 °C; preferably, the temperature is 67 °C;

(2) Weigh aloe vera gel, hyaluronic acid and medical vaseline in parts by weight, put them in a stirring tank and mix them at 50-55°C to obtain mixture B; preferably, mix them at 53°C to obtain a mixture B;

(3) Add mixture A while stirring mixture B, stir evenly, and cool to room temperature to obtain the special hand cream for auto repair workers of the present invention.

Compared with the prior art, the present invention has the following advantages:

The invention has simple production process and low production cost. After mixing beeswax, peony seed oil, corn germ oil, aloe gel, hyaluronic acid and other substances, the invention can treat the hand injury caused by long-term use of washing powder and sawdust by auto repair workers. Dry, smelly problems have a better therapeutic effect.

detailed description

The present invention will be further described below in conjunction with specific embodiments, and the advantages and characteristics of the present invention will become clearer along with the description. However, the examples are merely exemplary and do not limit the scope of the present invention in any way. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

Example 1

A special hand cream for auto repair workers, consisting of the following raw materials in parts by weight:

3.5 parts of beeswax, 3 parts of peony seed oil, 3.2 parts of corn germ oil, 18 parts of aloe vera gel, 22 parts of hyaluronic acid, 22 parts of medical petrolatum, 3.3 parts of shea butter, 0.14 parts of Nepal gold ester.

The preparation method of above-mentioned hyaluronic acid is as follows:

(1) Preparation of hyaluronic acid

Take the veterinary streptococcus on the slope and inoculate it into a 500mL Erlenmeyer flask containing 100mL of seed medium, put it into a shaker at 37°C, and cultivate it at a speed of 180 rpm for 20 hours, and inoculate it into a flask containing 7L of fermentation medium. In a 14L fermenter, the inoculum size is 10%, the fermentation conditions are 37°C, pH 6.7, ventilation rate 2.4L/h, stirring speed 150 rpm, and culture for 48 hours;

Seed medium (g/L): glucose 20.0, yeast extract 10.0, beef extract 10.0, MgSO ₄ 7H ₂ O 2.0, MnSO ₄ 4H ₂ O 0.1, KH ₂ PO ₄ 2.0, CaCO ₃ 20, trace element solution 1mL /L and buffer solution 40mL/L; among them, trace element solution: CaCl ₂ 2000mg/L, MnSO ₄ 4H ₂ O 24mg/L, ZnCl ₂ 46mg/L, CuSO ₄ 5H ₂ O 19mg/L; buffer solution: NaHPO ₄ 12H ₂ O 36.76g/L, NaH ₂ PO ₄ 12H ₂ O 15.98g/L, NaHCO ₃ 12.5g/L, adjust the pH to 6.8, and sterilize at 120°C for 15 minutes;

Fermentation medium (g/L): glucose 45.0, yeast extract 20.0, K ₂ SO ₄ 1.3, MgSO ₄ 7H ₂ O 2.0, Na ₂ HPO ₄ 12H ₂ O 6.2, FeSO ₄ 7H ₂ O 0.005, trace elements Solution 2.5mL/L, adjust the pH to 6.7, and sterilize at 120°C for 15min.

(2) Extraction of hyaluronic acid

Adopt ethanol precipitation method to obtain pure white powder which is hyaluronic acid.

Prepare above-mentioned hand cream, concrete method is as follows:

(1) Weigh beeswax, peony seed oil, corn germ oil, shea butter and Nepalese gold ester in parts by weight, put them into a stirring tank and stir evenly to obtain a mixture A, and heat the mixture A in a water bath to 67°C;

(2) Weigh aloe vera gel, hyaluronic acid and medical vaseline according to parts by weight, put them into a stirring tank and mix them at 53°C to obtain mixture B;

(3) Add mixture A while stirring mixture B, stir evenly, and cool to room temperature to obtain the special hand cream for auto repair workers of the present invention.

Example 2

A special hand cream for auto repair workers, consisting of the following raw materials in parts by weight:

3 parts of beeswax, 3 parts of peony seed oil, 3.1 parts of corn germ oil, 16 parts of aloe vera gel, 17 parts of hyaluronic acid, 24 parts of medical petrolatum, 3.6 parts of shea butter, 0.1 part of Nepal gold ester.

The preparation method of above-mentioned hyaluronic acid is as follows:

(1) Preparation of hyaluronic acid

Take the veterinary streptococcus on the slope and inoculate it into a 500mL Erlenmeyer flask containing 100mL of seed medium, put it into a shaker at 37°C, and cultivate it at a speed of 180 rpm for 20 hours, and inoculate it into a flask containing 7L of fermentation medium. In a 14L fermenter, the inoculum size is 10%, the fermentation conditions are 37°C, pH 6.9, ventilation rate 2.4L/h, stirring speed 150 rpm, and culture for 48 hours;

Seed medium (g/L): glucose 20.0, yeast extract 10.0, beef extract 10.0, MgSO ₄ 7H ₂ O 2.0, MnSO ₄ 4H ₂ O 0.1, KH ₂ PO ₄ 2.0, CaCO ₃ 20, trace element solution 1mL /L and buffer solution 40mL/L; among them, trace element solution: CaCl ₂ 2000mg/L, MnSO ₄ 4H ₂ O 24mg/L, ZnCl ₂ 46mg/L, CuSO ₄ 5H ₂ O 19mg/L; buffer solution: NaHPO ₄ 12H ₂ O 36.76g/L, NaH ₂ PO ₄ 12H ₂ O 15.98g/L, NaHCO ₃ 12.5g/L, adjust the pH to 6.8, and sterilize at 120°C for 15 minutes;

Fermentation medium (g/L): glucose 45.0, yeast extract 20.0, K ₂ SO ₄ 1.3, MgSO ₄ 7H ₂ O 2.0, Na ₂ HPO ₄ 12H ₂ O 6.2, FeSO ₄ 7H ₂ O 0.005, trace elements Solution 2.5mL/L, adjust the pH to 6.7, and sterilize at 120°C for 15min.

(2) Extraction of hyaluronic acid

Adopt ethanol precipitation method to obtain pure white powder which is hyaluronic acid.

Prepare above-mentioned hand cream, concrete steps are as follows:

(1) Weigh beeswax, peony seed oil, corn germ oil, shea butter and Nepalese gold ester in parts by weight, put them into a stirring tank and stir evenly to obtain a mixture A, and heat the mixture A in a water bath to 65°C;

(2) Weigh aloe vera gel, hyaluronic acid and medical vaseline according to parts by weight, put them into a stirring tank and mix them at 51°C to obtain mixture B;

(3) Add mixture A while stirring mixture B, stir evenly, and cool to room temperature to obtain the special hand cream for auto repair workers of the present invention.

Example 3

A special hand cream for auto repair workers, consisting of the following raw materials in parts by weight:

4.6 parts of beeswax, 2.8 parts of peony seed oil, 3.1 parts of corn germ oil, 22 parts of aloe vera gel, 19 parts of hyaluronic acid, 23 parts of medical petrolatum, 4.5 parts of shea butter, 0.17 parts of Nepal gold ester.

The preparation method of above-mentioned hyaluronic acid is as follows:

(1) Preparation of hyaluronic acid

Take the veterinary streptococcus on the slope and inoculate it into a 500mL Erlenmeyer flask containing 100mL of seed medium, put it into a shaker at 37°C, and cultivate it at a speed of 180 rpm for 20 hours, and inoculate it into a flask containing 7L of fermentation medium. In a 14L fermenter, the inoculum size is 10%, the fermentation conditions are 37°C, pH 6.8, ventilation rate 2.4L/h, stirring speed 150 rpm, and culture for 48 hours;

Seed medium (g/L): glucose 20.0, yeast extract 10.0, beef extract 10.0, MgSO ₄ 7H ₂ O 2.0, MnSO ₄ 4H ₂ O 0.1, KH ₂ PO ₄ 2.0, CaCO ₃ 20, trace element solution 1mL /L and buffer solution 40mL/L; among them, trace element solution: CaCl ₂ 2000mg/L, MnSO ₄ 4H ₂ O 24mg/L, ZnCl ₂ 46mg/L, CuSO ₄ 5H ₂ O 19mg/L; buffer solution: NaHPO ₄ 12H ₂ O 36.76g/L, NaH ₂ PO ₄ 12H ₂ O 15.98g/L, NaHCO ₃ 12.5g/L, adjust the pH to 6.8, and sterilize at 120°C for 15 minutes;

Fermentation medium (g/L): glucose 45.0, yeast extract 20.0, K ₂ SO ₄ 1.3, MgSO ₄ 7H ₂ O 2.0, Na ₂ HPO ₄ 12H ₂ O 6.2, FeSO ₄ 7H ₂ O 0.005, trace elements Solution 2.5mL/L, adjust the pH to 6.7, and sterilize at 120°C for 15min.

(2) Extraction of hyaluronic acid

Adopt ethanol precipitation method to obtain pure white powder which is hyaluronic acid.

The preparation method of special hand cream for auto repair workers of the present invention is as follows:

(1) Weigh beeswax, peony seed oil, corn germ oil, shea butter and Nepal gold ester in parts by weight, put them into a stirring tank and stir evenly to obtain a mixture A, and heat the mixture A in a water bath to 68°C;

(2) Weigh aloe vera gel, hyaluronic acid and medical vaseline according to parts by weight, put them into a stirring tank and mix them at 54°C to obtain mixture B;

(3) Add mixture A while stirring mixture B, stir evenly, and cool to room temperature to obtain the special hand cream for auto repair workers of the present invention.

Test case

50 auto repair workers voluntarily participate in the detection and investigation of hand cream of the present invention, wherein 25 smear common hand cream, 25 smear hand cream of the present invention, use twice a day, each time sooner or later, detect 10 days, observe daily Moisturizing effect, the results show that the hand cream of the present invention has a long moisturizing effect and can effectively repair the damage caused by washing powder and sawdust.

Claims (5)

1. A special hand cream for auto repair workers, characterized in that it is made up of the following raw materials in parts by weight: 3-5 parts of beeswax, 2-3 parts of peony seed oil, 3-4 parts of corn germ oil, 15-25 parts of aloe vera gel, 15-25 parts of hyaluronic acid, 20-30 parts of medical vaseline, 3-5 parts of shea butter parts, 0.1-0.2 parts of Nepal gold ester; Wherein, the preparation method of described hyaluronic acid is as follows: (1) Preparation of hyaluronic acid Take Streptococcus zooepidemicus on the slant and inoculate it into a 500mL Erlenmeyer flask containing 100mL of seed medium, put it into a shaker for cultivation at 37°C with a rotation speed of 180 rpm, cultivate for 20h, and inoculate into a flask containing 7L of fermentation medium. In a 14L fermenter, the inoculum size is 10%, the fermentation conditions are 37°C, pH 6.7, ventilation rate 2.4L/h, stirring speed 150 rpm, and culture for 48 hours; Seed medium: glucose 20.0, yeast extract 10.0, beef extract 10.0, MgSO ₄ 7H ₂ O 2.0, MnSO ₄ 4H ₂ O0.1, KH ₂ PO ₄ 2.0, CaCO ₃ 20, the above content units are g/L, Trace element solution 1mL/L and buffer solution 40mL/L; Among them, trace element solution: CaCl ₂ 2000mg/L, MnSO ₄ 4H ₂ O 24mg/L, ZnCl ₂ 46mg/L, CuSO ₄ 5H ₂ O 19mg/L ; Buffer: NaHPO ₄ 12H ₂ O 36.76g/L, NaH ₂ PO ₄ 12H ₂ O 15.98g/L, NaHCO ₃ 12.5g/L, adjust pH to 6.8, sterilize at 120°C for 15min; Fermentation medium: glucose 45.0, yeast extract 20.0, K ₂ SO ₄ 1.3, MgSO ₄ 7H ₂ O 2.0, Na ₂ HPO ₄ 12H ₂ O 6.2, FeSO ₄ 7H ₂ O 0.005, the above content units are g/ L, trace element solution 2.5mL/L, adjusted to pH 6.7, sterilized at 120°C for 15 minutes; (2) Extraction of hyaluronic acid Adopt ethanol precipitation method to obtain pure white powder which is hyaluronic acid. 2. the special hand cream for auto repair workers according to claim 1, is characterized in that, is made up of following raw material by weight: 3.5 parts of beeswax, 3 parts of peony seed oil, 3.2 parts of corn germ oil, 18 parts of aloe vera gel, 22 parts of hyaluronic acid, 22 parts of medical petrolatum, 3.3 parts of shea butter, 0.14 parts of Nepal gold ester. 3. prepare the method for the special hand cream for auto repair workers as claimed in claim 1 or 2, concrete steps are as follows: (1) Weigh beeswax, peony seed oil, corn germ oil, shea butter and Nepal gold ester in parts by weight, put them into a stirring tank and stir evenly to obtain mixture A, and heat mixture A in a water bath to 65-69 ℃; (2) Weigh aloe vera gel, hyaluronic acid and medical vaseline according to parts by weight, put them into a stirring tank and mix them at 50-55°C to obtain mixture B; (3) Add mixture A while stirring mixture B, stir evenly, and cool to room temperature to obtain. 4. The method according to claim 3, characterized in that, in the step (1), the temperature of heating the mixture A in a water bath is 67°C. 5. The method according to claim 3, characterized in that, in the step (2), the aloe vera gel, hyaluronic acid and medical vaseline are weighed in parts by weight and put into a stirring tank for mixing at 53°C.