CN104415162B - Treat Chinese medicine composition of leukopenia after chemoradiotherapy and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating leukopenia after radiotherapy and chemotherapy and a preparation method thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition of the present invention comprises the following raw materials by weight: Codonopsis 10-20 parts, Poria cocos 10-20 parts, Rhodiola rosea 15-45 parts, Lycium barbarum 10-20 parts, Ligustrum lucidum 10-20 parts, fairy 5‑15 parts of spleen, 5‑15 parts of dodder seed, 5‑15 parts of tangerine peel. The traditional Chinese medicine composition of the present invention has the characteristics of invigorating the spleen and replenishing qi, replenishing essence and nourishing the marrow, and has mild medicinal properties, neither warm nor dry, can effectively correct pathological factors such as visceral dysfunction, deficiency of essence and qi, etc., and improve mental fatigue, weakness of the waist and knees, Symptoms such as anorexia and loose stools can protect bone marrow hematopoietic function, increase white blood cells, and improve the completion rate of radiotherapy and chemotherapy.

Description

Traditional Chinese medicine composition for treating leukopenia after radiotherapy and chemotherapy and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine composition for treating leukopenia after radiotherapy and chemotherapy, in particular to a Chinese medicine composition for treating malignant tumor leukopenia after radiotherapy and chemotherapy. The invention also relates to a preparation method of the Chinese medicine composition, which belongs to the field of traditional Chinese medicine .

Background technique

Tumor is one of the major diseases that endanger human health. According to the data released by WHO in 2003, in 2000, there were 10 million malignant tumor patients in the world, including 5.3 million males and 4.7 million females; 6.2 million deaths due to malignant tumors, accounting for 12% of the total deaths, this figure in developed countries Up to 25%. In developing countries, due to the acceleration of urbanization and changes in lifestyle and eating habits, the occurrence of tumors closely related to them will gradually change to the type of economically developed countries. If this trend cannot be improved, it is expected that by 2020, the number of new malignant tumor cases worldwide will reach 15 million per year. Combination of traditional Chinese and western medicine to treat malignant tumors proceeds from the reality of our country and integrates the advantages of both Chinese and western medicine. its advantages. This superior curative effect is caused by truncating and reversing the pathological links of malignant tumors.

Radiotherapy and chemotherapy belong to the "attack" category of traditional Chinese medicine, and its common toxic and side effects are mainly manifested in two aspects: one is bone marrow suppression, including leukopenia, anemia, and thrombocytopenia; the other is gastrointestinal tract reactions, including appetite Decline, nausea and vomiting, abdominal distension and diarrhea and other symptoms. Almost all chemotherapeutic drugs have varying degrees of myelosuppression. Because white blood cells proliferate rapidly and have a short lifespan, it is the white blood cells that are most affected by myelosuppression. Leukopenia often affects the smooth completion of chemotherapy, and even leads to severe infection and death. Prevention and treatment of myelosuppression caused by chemotherapy is an urgent link in the treatment of cancer patients that needs to be cut off and reversed. Generally, Western medicines for increasing leukocytes, such as leucogen, batyl alcohol, etc., have poor curative effects. Granulocyte colony-stimulating factor is used for leukopenia caused by chemotherapy, and the effect is quick, which solves the difficult problem of continuing chemotherapy due to leukopenia to a large extent, but the price is expensive, and some patients have rebound phenomenon, fever, bone Pain and other side effects. Many scholars believe that the use of granulocyte colony-stimulating factor together with chemotherapy drugs can reduce the efficacy of chemotherapy and may stimulate the growth of certain tumors.

The main manifestations of leukopenia caused by radiotherapy and chemotherapy are dizziness, mental fatigue, weakness of the waist and knees, palpitation, shortness of breath, fatigue and insomnia, sweating when moving, etc., which belong to the category of "consumptive fatigue" in traditional Chinese medicine. "Jingyue Quanshu" said: "People with spleen and kidney deficiency and weak disorders often have accumulated diseases", which shows that the occurrence of tumors often has the deficiency of viscera, especially the deficiency of spleen and kidney, and the deficiency of viscera And dysfunction or innate endowment deficiency is the intrinsic factor of tumor. The theory of traditional Chinese medicine believes that the spleen is the foundation of acquired constitution and the source of Qi and blood biochemistry. Among the five viscera, the function of the spleen and stomach is particularly important. It nourishes the other four viscera. If the spleen and stomach are strong, the four viscera will be healthy and the body’s functions and activities will remain normal. If the spleen and stomach are weakened, the four viscera will also decline, and all diseases will arise. Spleen deficiency plays a key role in the pathogenesis of tumors. Spleen deficiency leads to passive biochemistry of qi and blood, and deficiency of qi and blood leads to a decline in the body's disease resistance; Qi stagnation and blood stasis, phlegm and blood stasis intertwine with the passing of time, send out into cancerous tumor. The kidney is the foundation of innate nature, containing the essence of yin and yang, and is the origin of life. The kidney stores the essence and produces the marrow, and the marrow resides in the bone. If the kidney essence is sufficient, the bone marrow will be active in biochemistry and generate blood vigorously. Deficiency of kidney qi is also an important factor in the occurrence and development of tumors. Asthenia is mostly due to deficiency of both spleen and kidney, strengthening the spleen and nourishing the kidney is the key to treatment, and clinical treatment should pay special attention to the dual nourishment of yin and yang. When righteousness is abundant, the vigor of the viscera and organs will be vigorous, and the hematopoietic ability of the bone marrow will also be enhanced.

Contents of the invention

The object of the present invention is to provide a kind of Chinese medicine composition and preparation method thereof for the treatment of leukopenia after radiotherapy and chemotherapy. Yin, with fairy spirit spleen, dodder seed warming and tonifying kidney yang, nourishing bones and promoting marrow, and tangerine peel to regulate qi and harmonize stomach, the whole prescription is mild in nature, neither warm nor dry. The treatment of leukopenia after radiotherapy and chemotherapy has a good effect.

In order to achieve the above object, the present invention adopts following technical scheme:

The traditional Chinese medicine composition for treating leukopenia after radiotherapy and chemotherapy is characterized in that it includes the following raw materials in parts by weight: Codonopsis 10-20 parts, Poria cocos 10-20 parts, Rhodiola rosea 15-45 parts, Lycium barbarum 10-20 parts 10-20 parts of privet fruit, 5-15 parts of fairy spleen, 5-15 parts of dodder seed, 5-15 parts of tangerine peel.

The preferred parts by weight of each raw material are: 15 parts of Codonopsis pilosula, 15 parts of Poria cocos, 30 parts of rhodiola rosea, 15 parts of medlar, 15 parts of Ligustrum lucidum, 10 parts of fairy spleen, 10 parts of dodder, and 10 parts of tangerine peel.

Codonopsis pilosula is sweet and flat in nature, and belongs to the two meridians of the lung and spleen. "Materia Medica Justice" records: nourishing the spleen and nourishing the stomach, nourishing the lungs and promoting body fluid, and tendon transporting Qi. This is not far from ginseng. Especially valuable ones can invigorate the spleen without dryness, nourish stomach yin without dampness, moisten the lungs without coldness, nourish blood without being too greasy, encourage clear yang, and vibrate the middle qi without the disadvantage of rigidity and dryness.

Poria cocos is sweet and flat, invigorates the spleen and dampness, calms the mind and calms the nerves. It is a holy medicine for dispelling dampness. For diarrhea and vaginal discharge caused by spleen deficiency, Poria cocos has the effect of taking care of both specimens. It is often used together with Codonopsis pilosula to resonate the vitality of the spleen and stomach and tonify The day after tomorrow.

Rhodiola is sweet, bitter, and flat in nature, nourishing qi, activating blood, and dredging the meridians. It is used for qi deficiency and blood stasis, chest pain, heart pain, stroke hemiplegia, and burnout. "Ginseng", the "Compendium of Materia Medica" records: the top grade of this classic, dispelling evil, evil spirits, and supplementing deficiencies, is rare in known tonic medicines. At present, rhodiola is mainly used to improve the immune function of the body, protect and promote Restorative ability, enhance immune cell activity. The combined application of rhodiola and chemotherapy drugs can reduce the toxic and side effects of chemotherapy, improve the effect of chemotherapy, increase the patient's tolerance to surgery, radiotherapy or chemotherapy, and promote the recovery of the body's immune function after surgery. Modern studies have proved that salidroside may stimulate the proliferation of hematopoietic progenitor cells in bone marrow-suppressed anemic mice through indirect or direct effects, so as to promote the recovery of hematopoietic function.

Lycium barbarum is sweet and flat in nature and taste, nourishing the liver and kidney, benefiting essence and improving eyesight. Long-term, fire can be reduced, rheumatism can be removed, and it has all kinds of magical effects." Modern research has proved that wolfberry has a regulatory effect on immunity, anti-aging, anti-tumor, protecting the liver, and promoting hematopoietic function. It also has a significant effect on normal healthy people. High leukocyte function.

Ligustrum lucidum is sweet, bitter and cool, which can nourish the Yin of the liver and kidney. It was first recorded in the Eastern Han Dynasty, and it was listed as the top grade in "Shen Nong's Materia Medica". "Compendium of Materia Medica" contains: "Ligustrum lucidum, with a yin smell, is entering the kidney to remove heat and replenish essence. If the kidney is nourished, the five internal organs will be at ease, the spirit will be self-sufficient, all diseases will be eliminated, and the body will be fat and healthy."

The fairy spleen is Epimedium, which is pungent, sweet and warm in nature and has the functions of invigorating the kidney and strengthening yang, strengthening muscles and bones, and expelling wind and dampness. "Ben Jing" first recorded "beneficial energy, strong will", Li Shizhen said in "Compendium of Materia Medica" that it has the effect of "benefiting essence, strengthening muscles and bones, strengthening waist and knees, and strengthening heart". Modern pharmacological experimental research shows that Epimedium can promote hematopoietic function, immune function and bone metabolism, and has anti-aging and anti-tumor effects.

Cuscuta is sweet and savory in nature and taste, nourishes kidney and essence, nourishes liver and improves eyesight. This product is pungent to moisten dryness, sweet to invigorate deficiency, and is a product for tonifying yin and yang. According to "Rihuazi Materia Medica": nourish five fatigue and seven injuries, control diarrhea, hematuria, and moisten the heart and lungs.

Tangerine peel has a bitter and warm nature and taste, returns to the spleen and lung meridian, regulates qi and invigorates the spleen, dries dampness and resolves phlegm. Jiao, so that the ascending and descending orderly, to treat vomiting and hiccups. "Materia Medica Huiyan" contains: the taste is pungent and good to loose, so it can open the qi; the stomach is bitter and ventilated, so it can make phlegm;

The whole party's monarchs, ministers and envoys are well organized, which is not only in line with ancient methods, but also has new ideas. The above medicines are integrated to nourish yin and nourish yang, which embodies the meaning that yin and yang are mutually rooted, and yin promotes yang and grows. Codonopsis pilosula and Poria cocos invigorate the spleen and replenish qi, which can not only improve spontaneous sweating and fatigue symptoms, but also promote appetite and enhance the effect of nourishing blood; wolfberry fruit and privet privet fruit nourish the yin of liver and kidney and nourish blood; fairy spleen and dodder seed warm and nourish kidney yang , warm but not dry, tangerine peel regulates qi and invigorates the spleen and stomach, which not only helps the medicine to work, prevents the stomach from being greasy, but also effectively relieves the adverse reactions of the digestive system caused by radiotherapy and chemotherapy. This prescription is qi, blood, yin and yang, and nourishes the liver, spleen and kidney. In addition to significantly increasing the effect of white blood cells, it has good curative effects on relieving clinical symptoms such as mental fatigue, weakness of the waist and knees, palpitations, insomnia, spontaneous sweating and night sweating, and has no side effects. reaction.

The present invention also provides a preparation method for the above-mentioned traditional Chinese medicine composition. Each raw material is weighed according to the weight portion, each raw material is pulverized, sieved, and various auxiliary materials required for preparing different dosage forms are added, such as disintegrating agent, Lubricants, adhesives, etc., are prepared into any suitable clinical preparations by conventional traditional Chinese medicine preparation methods, such as capsules, pills, powders, granules, tablets, oral liquids or drop pills, etc., preferably granules .

Preferably, a method for preparing the Chinese medicine composition of the present invention comprises the following steps:

(1) Weigh each API according to the stated parts by weight;

(2) Distill the fairy spleen, rhodiola rosea and tangerine peel respectively to extract the volatile oil, coat the volatile oil and crush it, and set aside;

(3) Extract Codonopsis pilosula, Lycium barbarum and Ligustrum lucidum with ethanol with a volume fraction of 30-95%, spray-dry the ethanol extract, and set aside;

(4) Extract the fairy spleen, rhodiola rosea, tangerine peel dregs, codonopsis pilosula, wolfberry, privet fruit, poria cocos, and dodder seed with water after extracting the volatile oil, spray the water extract to dry, and set aside;

(5) Mix the products obtained in steps (2), (3) and (4) evenly, add pharmaceutical preparation auxiliary materials and mix well to make a semi-finished preparation, and then make a finished preparation through the preparation molding process.

Preferably, the ethanol described in the above step (3) is ethanol with a volume fraction of 95%, and the added weight of ethanol is 3-5 times of the total weight of the drug, extracted 2-4 times, each extraction for 1.5-2.5 hours .

Preferably, the above step (4) is extracted twice with water, the weight of adding water for the first time is 3-5 times of the total weight of the drug, decocting for 2-4 hours, and the weight of adding water for the second time is 3-5 times of the total weight of the drug 1.5-3 times, decocting for 0.5-1.5 hours.

In addition, it also includes the use of the traditional Chinese medicine composition prepared by the invention in the preparation of medicines for treating leukopenia after radiotherapy and chemotherapy.

The traditional Chinese medicine composition of the invention has the functions of protecting bone marrow, increasing leukocytes during radiotherapy and chemotherapy in patients with malignant tumors, enhancing the immunity of patients, improving gastrointestinal function, so as to reduce adverse reactions of radiotherapy and chemotherapy and improve the completion rate of radiotherapy and chemotherapy. Moreover, the traditional Chinese medicine composition of the present invention is safe in clinical use, and patients do not have any adverse reactions after use, and can effectively improve the systemic functions of patients, and no adverse reactions will occur after the drug of the present invention is stopped.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments, and the advantages and characteristics of the present invention will become clearer along with the description. However, the examples are merely exemplary and do not limit the scope of the present invention in any way. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

The preparation of embodiment 1 hard capsule

(1) Weigh each raw material decoction piece according to the following weight: Codonopsis 1500g, Poria cocos 1500g, Rhodiola rosea 3000g, wolfberry fruit 1500g, privet fruit 1500g, fairy spleen 1000g, dodder seed 1000g, tangerine peel 1000g.

(2) Distill Rhodiola rosea, Xianlingpi, and tangerine peel to extract volatile oils, take β-cyclodextrin 10 times the amount of volatile oils from Rhodiola rosea, Xianlingpi, and tangerine peel, and then add 3 times the amount of β-cyclodextrin After mixing with ethanol with a volume fraction of 40%, use a colloid mill to homogenize for 15 minutes for clathrate, refrigerate the clathrate homogeneous solution for 24 hours, then filter, and dry the clathrate after filtration at 40°C After crushing, spare;

(3) Extract Codonopsis pilosula, Ligustrum lucidum, and Lycium barbarum with 95% ethanol, the weight of ethanol is 4 times the total weight of the drug, extract 3 times, each extraction is 2 hours, combine the extracts, filter , the filtrate is concentrated to a clear paste with a relative density of 1.30-1.35 (55°C), spray-dried to prepare a fine powder, and set aside;

(4) Extract the fairy spleen, rhodiola rosea, tangerine peel dregs, codonopsis pilosula, wolfberry, privet fruit, poria cocos, and dodder together with water for two times after the volatile oil is extracted, and the weight of adding water for the first time is 4% of the total weight of the drug. times, decocted for 3 hours, the weight of water added for the second time was twice the total weight of the drug, and decocted for 1 hour; the two decoctions were combined, filtered, and the filtrate was concentrated to a relative density of 1.30-1.35 (55 degrees Celsius ℃) clear paste, spray-dried to prepare fine powder, and set aside;

(5) Mix the products obtained in steps (2), (3) and (4) evenly, add appropriate amount of dextrin and total stevioside, mix evenly, add appropriate amount of ethanol to make granules, dry at low temperature, and set aside;

(6) Sizing the dry granules prepared in (5) to prepare uniform granules for later use;

(7) Fill the uniform granules prepared in (6) into the hard capsule shell with an automatic capsule filling machine, and set aside;

(8) Polish or seal the hard capsule in (7).

The preparation of embodiment 2 powder

Take each bulk drug by the following weight: Codonopsis 1500g, Poria cocos 1500g, Rhodiola rosea 3000g, medlar fruit 1500g, Ligustrum lucidum 1500g, fairy spleen 1000g, dodder seed 1000g, tangerine peel 1000g; Mesh sieve, that is.

The preparation of embodiment 3 granules

(1) Weigh each raw material according to the following weight: Codonopsis 1500g, Poria cocos 1500g, Rhodiola rosea 3000g, medlar 1500g, Ligustrum lucidum 1500g, fairy spleen 1000g, dodder 1000g, tangerine peel 1000g;

(2) Extract volatile oil from Rhodiola rosea, fairy spleen, and tangerine peel, coat the volatile oil and crush it, and set aside;

(3) Extract Codonopsis pilosula, Ligustrum lucidum fruit, Lycium barbarum fruit and Cuscuta fruit with a volume fraction of 95% ethanol, and the weight of ethanol added is 4 times the total weight of the drug, and the extraction is performed 3 times, each time for 2 hours, and the extracts are combined, Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.30-1.35 (55°C), spray dry to prepare a fine powder, and set aside;

(4) Extract the fairy spleen, rhodiola rosea, tangerine peel dregs, Codonopsis pilosula, Lycium barbarum, Ligustrum lucidum, Poria cocos, and Cuscuta after extracting the volatile oil with water twice, and the weight of adding water for the first time is 3% of the total weight of the medicine. times, decocted for 3 hours, the weight of water added for the second time was twice the total weight of the drug, and decocted for 1 hour; the two decoctions were combined, filtered, and the filtrate was concentrated to a relative density of 1.30-1.35 (55 degrees Celsius ℃) clear paste, spray-dried to prepare fine powder, and set aside;

(5) Mix the products obtained in steps (2), (3) and (4) evenly, add appropriate amount of dextrin and total stevioside, mix evenly, add appropriate amount of ethanol to make granules, dry at low temperature, granulate, divide Put it on and get it.

Experimental Example 1: Curative Effect Observation on Patients with Leukopenia Caused by Chemotherapy for Malignant Tumors

1. Materials and methods

1.1 Source of cases

From January 2009 to December 2012, there were 100 outpatients and inpatients in Changzhou Cancer Hospital. The patients were randomly divided into a Chinese medicine treatment group of 50 cases and a control group of 50 cases. In the traditional Chinese medicine treatment group, there were 22 males and 28 females; aged 31-75 years, with a median age of 56 years, including 8 cases of lung cancer, 20 cases of breast cancer, 3 cases of esophageal cancer, 10 cases of gastric cancer, 6 cases of colorectal cancer, cervical cancer 3 cases of cancer. In the control group, there were 24 males and 26 females; aged 32-75 years, with a median age of 55 years; including 9 cases of lung cancer, 16 cases of breast cancer, 4 cases of esophageal cancer, 10 cases of gastric cancer, 6 cases of colorectal cancer, and cervical cancer. 5 cases. There was no significant difference in gender, age, pathological type and stage, white blood cell count and neutrophil count before chemotherapy between the two groups, and they were comparable. All the above cases were confirmed by pathology. The white blood cells in laboratory tests were all lower than 4×10 ⁹ /L, meeting the standard of leukopenia.

1.2 Treatment methods

Treatment group: self-prepared traditional Chinese medicine prescription: Codonopsis 15g, Poria cocos 15g, Rhodiola rosea 30g, medlar fruit 15g, Ligustrum lucidum 15g, fairy spleen 10g, dodder seed 10g, dried tangerine peel 10g, one dose per day, decoction twice, and extract juice altogether 400ml, take twice in the morning and evening. Control group: Shengbaiyao was selected: 20 mg of batyl alcohol, 20 mg of lexogen, and 20 mg of vitamin B4 were given each time, 3 times a day. Course of treatment: 10 days for both groups is a course of treatment. After the course of treatment, the routine blood test is performed and the curative effect is counted. In all cases, the leukocytes were 3.0-4.0×10 ⁹ /L without continuous chemotherapy, and the leukocytes were less than 3.0×10 ⁹ /L and the chemotherapy was stopped. During the period of taking the medicine, strengthen nutrition, eat a high-protein, high-fat diet, and prevent infection.

1.3 Curative effect standard:

Refer to the curative effect standard of leukocyte-increasing drugs in the "Guiding Principles of Drug Clinical Research" formulated by the Ministry of Health. Markedly effective: after treatment, the total number of white blood cells rose to over 4.0×10 ⁹ /L, and maintained the curative effect during the course of treatment until 1 week after stopping the drug, and the clinical symptoms were significantly relieved or disappeared; effective: after treatment, white blood cells <4.0×10 ⁹ /L L, but increased by 0.5×10 ⁹ -1.0×10 ⁹ cells/L compared with before treatment, and the curative effect can be maintained during the course of treatment until 1 week after stopping the drug, and the clinical symptoms are improved; invalid: the total number of white blood cells increased by <0.5×10 ⁹ after treatment A/L, the clinical symptoms did not improve.

2. Treatment results

50 cases in the treatment group, 35 cases were markedly effective, 11 cases were effective, 4 cases were ineffective, and the total effective rate was 92%; 50 cases were in the control group, 18 cases were markedly effective, 17 cases were effective, and 15 cases were ineffective, and the total effective rate was 70%. There is a significant difference in curative effect after statistical treatment (P<0.05). For the patients' subjective symptoms such as dizziness, fatigue, spontaneous sweating, poor appetite, and poor sleep, the treatment group improved significantly.

3. Conclusion

The traditional Chinese medicine composition prepared by the invention has the functions of protecting bone marrow, increasing leukocytes of malignant tumor patients during chemotherapy, enhancing immunity of patients, improving gastrointestinal function, so as to reduce adverse reactions of chemotherapy and improve the completion rate of chemotherapy.

Claims (9)

1. treat the Chinese medicine composition of leukopenia after chemoradiotherapy, it is characterised in that by the bulk pharmaceutical chemicals of following parts by weight meter Composition：10-20 parts of Radix Codonopsis, 10-20 parts of Poria cocos, 15-45 parts of rhodiola root, 10-20 parts of the fruit of Chinese wolfberry, 10-20 parts of the fruit of glossy privet, HERBA EPIMEDII 5-15 parts, 5-15 parts of Semen Cuscutae, 5-15 parts of dried orange peel.

2. Chinese medicine composition according to claim 1, it is characterised in that the parts by weight of each bulk pharmaceutical chemicals are：15 parts of Radix Codonopsis, Fu 15 parts of Siberian cocklebur, 30 parts of rhodiola root, 15 parts of the fruit of Chinese wolfberry, 15 parts of the fruit of glossy privet, 10 parts of HERBA EPIMEDII, 10 parts of Semen Cuscutae, 10 parts of dried orange peel.

3. Chinese medicine composition according to claim 1 or 2, it is characterised in that be prepared into according to Chinese medicine preparation and clinically fit Suitable preparation.

4. Chinese medicine composition described in accordance with the claim 3, it is characterised in that the preparation includes capsule, pill, dissipates Agent, granule, tablet, oral liquid or pill.

5. a kind of method for preparing the Chinese medicine composition described in claim 1 or 2, its step include：Weighed by the parts by weight Each bulk pharmaceutical chemicals, each bulk pharmaceutical chemicals are crushed, and sieving, adds the auxiliary material or excipients needed for preparations shaping, be prepared into capsule, ball Agent, powder, granule, tablet, oral liquid or pill.

6. a kind of method for preparing the Chinese medicine composition described in claim 1 or 2, its step include：

(1) each bulk pharmaceutical chemicals are weighed by the parts by weight；

(2) HERBA EPIMEDII, rhodiola root, dried orange peel are distilled respectively, extracts volatile oil, crushed after volatile oil is coated with, it is spare；

(3) it is that 30-95% ethanol extracts with volume fraction by Radix Codonopsis, the fruit of Chinese wolfberry, the fruit of glossy privet, ethanol extract is spray-dried, It is spare；

(4) by HERBA EPIMEDII, rhodiola root, the dried orange peel dregs of a decoction and the Radix Codonopsis after extraction volatile oil, matrimony vine, the fruit of glossy privet, Poria cocos, Semen Cuscutae one Water extraction is reinstated, aqueous extract is spray-dried, it is spare；

(5) step (2), (3) and (4) obtained product is uniformly mixed, adds pharmaceutical preparation auxiliary materials and mixing and preparation half is made Finished product, then finished dosage form is made through preparations shaping technique.

7. preparation method according to claim 6, it is characterised in that the ethanol described in the step (3) selects volume Fraction is 95% ethanol, and ethanol adds 3-5 times that weight is the medicine gross weight, extracts 2-4 times, extract 1.5- every time 2.5 it is small when.

8. preparation method according to claim 6, it is characterised in that the number extracted in the step (4) with water is two Secondary, first time adds 3-5 times that water weight is the medicine gross weight, and when decoction 2-4 is small, for the second time plus water weight is the medicine 1.5-3 times of gross weight, when decoction 0.5-1.5 is small.

9. the Neuroleptic Leukocytopenia disease drug after treatment concurrent chemoradiotherapy of malignant tumor is prepared of the Chinese medicine composition described in claim 1 or 2 In purposes.