CN104381266A - Sterilization composition - Google Patents
Sterilization composition Download PDFInfo
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- CN104381266A CN104381266A CN201410497877.6A CN201410497877A CN104381266A CN 104381266 A CN104381266 A CN 104381266A CN 201410497877 A CN201410497877 A CN 201410497877A CN 104381266 A CN104381266 A CN 104381266A
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- fluopicolide
- chlorobenzene ether
- acid amides
- sterilization composition
- ether acid
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Abstract
The present invention belongs to the technical field of pesticides, and relates to a sterilization composition, which is characterized in that the active ingredients contain chlorophenyl ether amide and fluopicolide. The sterilization composition can be prepared into a suspension, and has characteristics of significant synergy effect, long persistence and environmental protection.
Description
Technical field
The invention belongs to technical field of pesticide, contain the composite bactericide with synergistic effect of fluopicolide and chlorobenzene ether acid amides specifically.
Background technology
Fluopicolide (fluopicolide) is the new type bactericide that Bayer Bitterfeld GmbH crop science company releases, and can protect efficiently and prevent and treat Oomycete vegetable disease.This product has excellent system conductive and stronger thin layer penetration power, all has good inhibitory action to each Main Morphology of pathogen, can provide comprehensive for young leaves, stem, stem tuber, young fruit and protect lastingly.Because medicament can absorb fast through blade face, so resistance of rainwater washing against, for vegetables diseases prevention in rainy season provides reliable guarantee.This product is mainly used in, on all kinds of vegetables and grape crop, having outstanding preventive effect to common oomycetes diseases such as downy mildew, epidemic disease, late blight, damping off, to crop and Environmental security, is specially adapted to high-quality, green vegetables are produced.
Chlorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, and have extraordinary effect to the common epidemic disease of cucumber, tomato, potato, downy mildew, active ingredient is novel, non-resistant.
Potato late blight (Potato Late Bright) is caused by phytophthora infestans, causes the crushing oomycetes disease of one that potato haulm is dead and stem tuber is rotten.
Summary of the invention
The object of this invention is to provide a kind of bactericidal composition with synergistic effect for preventing and treating potato late blight, compared with existing pesticide control, the object realize improving drug effect, reducing dosage.Be specifically related to fluopicolide and the composite bactericidal composition of chlorobenzene ether acid amides.
Utilize above-mentioned bactericidal composition, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, formulation of the present invention is suspending agent.
In above-mentioned microbicide compositions, the proportion of fluopicolide and chlorobenzene ether acid amides is 1:60-60:1.
Fluopicolide and chlorobenzene ether acid amides composite bactericide have following characteristics: 1. two kinds of active ingredients are composite, have good synergistic effect; 2. active ingredient is novel, non-resistant; 3. sterilization is rapid, and the lasting period is long.
First applicant uses these two kinds of compositions to carry out indoor biometrics experiment, experimental technique and result as follows:
First, after analyzing the action character of two kinds of active ingredients, the raw object surveyed is decided to be phytophthora infestans (Phytophthorainfestans (Mont.) de Bary) by us, and this bacterium can cause potato late blight.
The test method of indoor biometrics: reference standard NY/T1156.6-2006, adopts growth rate method to measure medicament to the inhibitory action of potato late blight pathogen mycelial growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the former medicine of 96% fluopicolide and the former medicine of 98% chlorobenzene ether acid amides with acetone to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking phytophthora infestans bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Above-mentioned raw survey experiment former medicine used and reagent are all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Indoor biometrics experimental data sees the following form:
Table 1 fluopicolide and chlorobenzene ether acid amides and different ratio thereof are to the measurement result of potato late blight co-toxicity coefficient
By above-mentioned data, obviously can find out that the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of potato late blight is had to the synergistic effect of different proportion when fluopicolide and chlorobenzene ether acid amides are composite in varing proportions.
Determine fluopicolide by indoor biometrics experiment and chlorobenzene ether acid amides two kinds of active ingredients are composite can good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 30.5% fluopicolide chlorobenzene ether amide suspending agents
Example two, 21.7% fluopicolide chlorobenzene ether amide suspending agents
Example three, 11% fluopicolide chlorobenzene ether amide suspending agents
Example four, 12% fluopicolide chlorobenzene ether amide suspending agents
Example five, 12% fluopicolide chlorobenzene ether amide suspending agents
Example six, 7% fluopicolide chlorobenzene ether amide suspending agents
Example seven, 24% fluopicolide chlorobenzene ether amide suspending agents
Example eight, 33% fluopicolide chlorobenzene ether amide suspending agents
Example nine, 62% fluopicolide chlorobenzene ether amide suspending agents
Example ten, 48.8% fluopicolide chlorobenzene ether amide suspending agents
Select above example to carry out preventing and treating the field trial of potato late blight, simultaneously by the Contrast on effect with fluopicolide and chlorobenzene ether acid amides single dose, verify composite after synergistic effect.Test site is area, Yanshan County of Yunnan Province, time is on June 12nd, 2013, test each process three repetition, community randomized arrangement, each plot area is 30m2, adopts back-pack electric compression sprayer, dispenser was sunny calm for the same day, the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is with reference to GB/T 17980.34-2000, each community diagonal 5 sampling, often some sampling 2-3 strain, investigates whole blade, calculates according to following grade scale:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area, stem stalk there is scab.
Within after dispenser 7 days first, carry out second time dispenser, 7 days and investigation in 17 days after dispenser first respectively.Computing formula is as follows:
Table 3 7% fluopicolide chlorobenzene ether amide suspending agents and different agents are to the preventive effect of potato late blight
Analyze above-mentioned data to draw, fluopicolide and chlorobenzene ether acid amides composite after after medicine 7 days preventive effects all more than 73%, and fluopicolide single dose 7 days preventive effects after medicine are 39.47%, the preventive effect of chlorobenzene ether acid amides single dose is 41.31%, has good synergistic effect after visible two kinds of active ingredients are composite.And after medicine 17 days, all complex preparations have all exceeded 75% to the preventive effect of potato late blight, and visible composite rear preparation extends the lasting period, and control efficiency is more lasting.
Claims (3)
1. a bactericidal composition, is characterized in that: active component is made up of chlorobenzene ether acid amides and fluopicolide, and the weight ratio of described chlorobenzene ether acid amides and fluopicolide is 1:60 ~ 60:1.
2. bactericidal composition according to claim 1, is characterized in that: make suspending agent by active component and auxiliary material.
3. bactericidal composition according to claim 1 and 2 is for preventing and treating the purposes of potato late blight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410497877.6A CN104381266A (en) | 2014-09-25 | 2014-09-25 | Sterilization composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410497877.6A CN104381266A (en) | 2014-09-25 | 2014-09-25 | Sterilization composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104381266A true CN104381266A (en) | 2015-03-04 |
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ID=52599317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410497877.6A Pending CN104381266A (en) | 2014-09-25 | 2014-09-25 | Sterilization composition |
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| Country | Link |
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| CN (1) | CN104381266A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104872136A (en) * | 2015-05-21 | 2015-09-02 | 华中师范大学 | Bactericide composition and preparation as well as application thereof |
| CN105076150A (en) * | 2015-08-13 | 2015-11-25 | 华中师范大学 | Bactericide composition and preparation and application thereof |
| CN106689135A (en) * | 2017-01-09 | 2017-05-24 | 张和林 | Biological combinational preparation for preventing and treating late blight of potato |
Citations (8)
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| CN101647446A (en) * | 2009-06-22 | 2010-02-17 | 陕西标正作物科学有限公司 | Bactericidal composite with fluopicolide and dimethomorph |
| CN101755798A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing fluazinam |
| CN101999356A (en) * | 2010-11-26 | 2011-04-06 | 惠州市中迅化工有限公司 | Sterilization composition containing fluopicolide and metalaxyl and application thereof |
| CN102204537A (en) * | 2011-05-05 | 2011-10-05 | 青岛海利尔药业有限公司 | Antibacterial composition containing fluopicolide and ethofenprox |
| CN102246760A (en) * | 2011-04-30 | 2011-11-23 | 江西海科瑞特作物科学有限公司 | Bactericidal composition containing fluopicolide and metalaxyl |
| CN102334493A (en) * | 2011-10-26 | 2012-02-01 | 陕西美邦农药有限公司 | Novel fluopicolide-containing antibacterial composition |
| CN102342287A (en) * | 2011-11-08 | 2012-02-08 | 陕西美邦农药有限公司 | Sterilization composition containing fluopicolide and polyoxin |
| CN102365956A (en) * | 2011-11-03 | 2012-03-07 | 陕西美邦农药有限公司 | Sterilization composition containing fluopicolide and methoxyl acrylic acid ester compounds |
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2014
- 2014-09-25 CN CN201410497877.6A patent/CN104381266A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647446A (en) * | 2009-06-22 | 2010-02-17 | 陕西标正作物科学有限公司 | Bactericidal composite with fluopicolide and dimethomorph |
| CN101755798A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing fluazinam |
| CN101999356A (en) * | 2010-11-26 | 2011-04-06 | 惠州市中迅化工有限公司 | Sterilization composition containing fluopicolide and metalaxyl and application thereof |
| CN102246760A (en) * | 2011-04-30 | 2011-11-23 | 江西海科瑞特作物科学有限公司 | Bactericidal composition containing fluopicolide and metalaxyl |
| CN102204537A (en) * | 2011-05-05 | 2011-10-05 | 青岛海利尔药业有限公司 | Antibacterial composition containing fluopicolide and ethofenprox |
| CN102334493A (en) * | 2011-10-26 | 2012-02-01 | 陕西美邦农药有限公司 | Novel fluopicolide-containing antibacterial composition |
| CN102365956A (en) * | 2011-11-03 | 2012-03-07 | 陕西美邦农药有限公司 | Sterilization composition containing fluopicolide and methoxyl acrylic acid ester compounds |
| CN102342287A (en) * | 2011-11-08 | 2012-02-08 | 陕西美邦农药有限公司 | Sterilization composition containing fluopicolide and polyoxin |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104872136A (en) * | 2015-05-21 | 2015-09-02 | 华中师范大学 | Bactericide composition and preparation as well as application thereof |
| CN105076150A (en) * | 2015-08-13 | 2015-11-25 | 华中师范大学 | Bactericide composition and preparation and application thereof |
| CN105076150B (en) * | 2015-08-13 | 2017-03-22 | 华中师范大学 | Bactericide composition and preparation and application thereof |
| CN106689135A (en) * | 2017-01-09 | 2017-05-24 | 张和林 | Biological combinational preparation for preventing and treating late blight of potato |
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Application publication date: 20150304 |