CN104188808B - A kind of nti-freckle is dispelled yellow gel and preparation method thereof - Google Patents

Abstract

The invention discloses a gel for removing freckles and yellowing and a preparation method thereof. The gel contains the following substances: evening primrose oil, grape seed oil, wheat germ oil, simple emulsifier SIMULGEL EG, olive emulsifier, and ice crystal forming agent AVC, 1% gel forming agent STABILEZE QM solution, sodium alginate, carbomer 941, 1,3-butanediol, 1,2-propylene glycol, rosemary extract, forget-me-not extract, 7% Nipole Gold ethyl alcohol solution (75% ethanol) and distilled water. Compared with the prior art, the freckle-removing and yellow-removing gel made by the present invention is milky white, transparent and crystal clear, suitable for viscosity, mild in nature, good in stability, moist and nourishing, and fragrant in smell, and can supply nutrients for facial skin, remove freckle and yellow , make the skin deeply nourished, moisturized and elastic.

Description

A kind of freckle-removing and yellow-removing gel and preparation method thereof

technical field

The invention relates to a preparation method of a gel, in particular to a freckle-removing and yellow-removing gel and a preparation method thereof.

Background technique

Spots are prone to occur on the face, and are light brown, dark brown, taupe pigmented spots, including freckles, dark spots, chloasma and age spots, etc., which are pigmented disordered skin diseases. Western medicine believes that it is a variation of photosensitive dermatitis or phototoxic dermatitis. Many cases have a history of contact with chemicals and inferior cosmetics. Some ingredients in cosmetics such as actor's oil paint or household cosmetics can occasionally cause pigmentation. Aggravated by sun exposure. Electromagnetic oscillation can stimulate melanin in the skin. Long-term exposure to computer radiation, poor sleep or insufficient rest at night, and high psychological and work pressure can all cause pigmentation. In addition, malnutrition and other factors may also cause this disease. The increase of clear copper ion content in most patients may be a sign of enhanced tyrosinase activity.

At present, the treatment methods for this stain are generally as follows:

1. By purely physical means, cover the skin with powder or thick paste to protect it from sunlight and pollution. But preventing the outside does not cure the inside, can not improve the color of the skin, and has relatively large side effects. Or use laser beauty to remove freckles, mainly using laser therapy equipment to emit specific wavelengths. Lasers of different wavelengths will be absorbed by the color or pigment in the skin. When the pigment is slowly absorbed by the body, the color of the pigmentation will become lighter. . But after all, laser speckle removal is a "compulsory speckle removal" that relies on external forces, and it cannot stop the formation of spots from the source.

2. Fruit acid skin peeling and spot removal: The selected fruit acid is a natural acid extracted from fruits. Fruit acid skin peeling and spot removal can remove spots located in the superficial layer of the skin epidermis, but for those located in the deep layer of the skin epidermis (basal layer) or Pigmented spots in the dermis are helpless. In addition, the requirements for using fruit acid for skin peeling and spot removal are extremely high, first of all, strict aseptic control is required; secondly, due to the use of high-concentration fruit acid, it will inevitably damage the skin stratum corneum, which will reduce the skin's ability to resist external aggression, and at the same time The skin loses moisture excessively and is prone to aging.

3. The cosmetics currently on the market are used, but most of them are mainly chemical raw materials. After random inspection by the national quality inspection agency, the content of harmful substances such as lead, mercury, and hydroquinone exceeds the specified standard by hundreds of times, and some even exceed 1,000 multiple times. Lead, mercury, etc. are toxic substances to human skin and nervous system, especially to liver, kidney and other organs, which can cause chronic poisoning, and the toxic ingredients contained in it can cause skin cancer. There are also some users who have serious skin damage at the rubbing place, leaving dark spots and scars that are difficult to heal, and the rebound rate is high. Although lead, mercury and other heavy metal ions can act on tyrosinase in the process of pigment production, making it inactive, thereby preventing the formation of spots and whitening the skin. But this effect is short-lived, and the ultimate consequence is that tyrosinase still catalyzes the regeneration of pigment without limit, which makes the skin darken, the pigment rebounds, and even spots of heavy metal poisoning appear. Many countries have banned the use of the above-mentioned highly toxic drugs for freckle-removing agents, and my country has also clearly stipulated that this type of highly toxic drugs must not be used or limited to be used for freckle-removing or other cosmetics.

The compound preparation of pure Chinese herbal medicine for freckle removal is recognized as one of the safest and most effective methods of freckle removal, and is also highly recommended by dermatologists. The invention provides a new freckle-removing and yellow-removing gel containing natural component extracts, which can whiten and moisturize the skin. And its safety is good.

Contents of the invention

In order to solve the above-mentioned technical problems, the present invention provides a freckle-removing and yellow-removing gel.

The invention also provides a preparation method of the freckle-removing and yellow-removing gel.

A freckle-removing and yellow-removing gel, 100g of which contains the following substances:

Described forget-me-not extract is prepared by the following method:

Weigh an appropriate amount of forget-me-nots, reflux and extract in water at 90-100°C for 3 times, add 5-25 times the amount of water for the first time, extract for 0.5-2 hours, use 5-20 times the amount of water for the second time, extract for 0.5-1.5 hours, and extract for the second time Add 5-10 times the amount of water three times, extract for 0.5-1h, filter each time with 3 layers of gauze, combine the filtrate, heat and concentrate to 5-20 times the weight of the forget-me-not g/ml, and obtain the forget-me-not extract.

Described rosemary extract is prepared by the following method:

Weigh a certain weight of rosemary, reflux and extract in water at 90-100°C for 3 times, add 5-25 times the amount of water for the first time, extract for 0.5-2h, filter with three layers of gauze, add 5-20 times for the second time Double the amount of water, extract 0.5-1.5h, filter, use 5-15 times the amount of water for the third time, extract 0.2-1h, filter, mix the filtrate three times, heat and concentrate to 5-15 times the weight of rosemary g/ml, Promptly obtain rosemary extract.

A kind of preparation method of freckle-removing and yellow-removing gel provided by the present invention, described preparation method comprises the following steps:

a) Weigh 0.1-0.3g of ice crystal forming agent AVC, add 15-25ml of distilled water, stir to dissolve, and become thickener 1;

b) Weigh 0.05-0.15g of carbomer, add 10-20ml of distilled water, let it stand still to make it swell, stir evenly to form a solution, which is thickener 2;

c) Weigh 0.02-0.2g of sodium alginate, add 10-20ml of distilled water, let it stand still to make it swell, stir evenly to form a solution, which is thickener 3;

d) Weigh 1-3g of evening primrose oil, 1-3g of wheat germ oil, 1-3g of grape seed oil, 0.1-1.0g of simple emulsifier SIMULGELEG, and 0.1-1.0g of olive oil emulsifier, and place them in a beaker , heat the beaker 1 in a water bath at 60-90°C as the oil phase;

e) Measure 1-9ml of 1,2-propanediol and 10-30ml of distilled water into beaker 2, and heat beaker 2 in a water bath at 60-90°C as the water phase;

f) After the water phase and the oil phase reach the same temperature, pour the water phase in the beaker 2 into the oil phase in a thin stream, and stir while adding until a uniform emulsion matrix is formed;

g) Add 0.1-2g of forget-me-not extract, 0.1-2g of rosemary extract, 0.1-2g of 1,3-butanediol, 7% ethylparaben alcohol solution (75% ethanol) to the emulsion base -3ml, stir evenly;

h) Then add thickener 1, thickener 2, thickener 3, 1-5 g of 1% gel forming agent STABILEZE QM solution into the beaker, and stir evenly to obtain the freckle and yellow gel.

Various compositions among the present invention are as follows:

Forget-me-nots are rich in vitamin C, which can slow down wrinkles and dark spots, whiten skin, clear liver and eyesight, nourish yin and kidney, nourish blood and nourish blood, and can promote body metabolism, delay cell aging, improve immunity, and prevent wrinkles and dark spots The occurrence of freckles, especially freckles and acne has a certain elimination effect, skin care and beauty, promote metabolism, and can effectively regulate women's physiological problems.

Rosemary is a natural spice plant. The natural antioxidant components extracted from rosemary mainly include carnosic acid, carnosol, rosmarinic acid, rosmanol, flavonoids, etc., which can effectively remove Free radicals in the human body and inhibit the degradation of human protein, thereby maintaining the elasticity and luster of the skin. The antibacterial, antimutagenic and anticancer properties of rosemary extract have been well documented.

The main components of evening primrose oil are oleic acid, linoleic acid, γ-linolenic acid, etc. These substances are important additives in cosmetics, making the skin soft and elastic, with good touch and ductility, and easy to be absorbed by skin microvessels. It can promote blood circulation, prevent keratinization of epidermal cells, keep the skin lubricated, and delay skin aging. The unsaturated fatty acid molecules in evening primrose oil provide sufficient toughness for the skin structure and prevent skin moisture loss, which can restore the normal barrier function of the skin. Moisturizing, promotes skin stretching, without excessive greasy feeling after use.

Wheat germ oil is rich in vitamin E, linoleic acid, linolenic acid, octadecyl alcohol and various physiologically active components. It has anti-free radical properties, can delay skin aging, has strong moisturizing properties, and can dilute fine lines and stretch marks , scars, increase skin moisture, very helpful to dry, dehydrated, aging, wrinkled skin, can reduce the marks left by acne on the face, suitable for all skin types, effective for dark spots, psoriasis, eczema It has a certain effect and also has sun protection function, which can be used for body sun protection.

Grape seed oil is rich in vitamin E and a certain amount of vitamin A, D and various trace elements. Grape seed oil is one of the most powerful free radical scavengers. It is a high-efficiency anti-oxidation and free radical scavenging product for beauty, skin care and health care. It is easily absorbed by the skin's connective tissue, which can help protect the skin from UV damage, nourish the skin, Reduces skin diseases and wrinkles and even eliminates scars. Grapeseed oil has a dual action on the skin, on the one hand it promotes moderate cross-linking of collagen and on the other hand it acts as a potent free radical scavenger preventing the skin from "over-cross-linking" which prevents wrinkles And the appearance of vesicles, keep the skin soft and smooth.

Compared with the prior art, the present invention improves the anti-wrinkle and spot-lightening properties of the gel prepared by the present invention by adding pure natural ingredients such as forget-me-not extract, rosemary extract, evening primrose oil, wheat germ oil and grape seed oil. , whitening and moisturizing effect. The invention provides a new freckle-removing and yellow-removing gel containing natural component extracts, which can whiten and moisturize the skin. And its safety is good.

detailed description

The present invention will be further described below in conjunction with the examples.

Evening primrose oil, wheat germ oil and grapeseed oil of the present invention are commercially available.

Example 1

1.1 Preparation of forget-me-not extract:

Weigh 20g of forget-me-nots, reflux and extract in water at 95°C for 3 times, add 20 times the amount of water for the first time, extract for 2 hours, use 15 times the amount of water for the second time, extract for 1.5 hours, add 10 times the amount of water for the third time, extract for 1 hour, Filter each time with 3 layers of gauze, combine the filtrates, heat and concentrate to 15 times g/ml of the weight of the forget-me-not, and obtain the forget-me-not extract.

1.2 Preparation of rosemary extract:

Weigh 10g of rosemary, reflux and extract in water at 100°C for 3 times, add 25 times the amount of water for the first time, heat and decoct for 2 hours, filter with three layers of gauze, add 20 times the amount of water for the second time, extract for 1.5 hours , filter, and use 15 times the amount of water for the third time, heat and decoct for 1 hour, filter, mix the filtrate three times, heat and concentrate to 15 times the weight of rosemary g/ml, and obtain the rosemary extract.

1.3 The preparation method of freckle-removing and yellow-removing gel

a) Weigh 0.2 g of ice crystal forming agent AVC, add 15 ml of distilled water, stir to dissolve, and become thickener 1;

b) Weigh 9410.09g of carbomer, add 10ml of distilled water, let it stand still to make it swell, stir evenly to form a solution, which is thickener 2;

c) Weigh 0.15 g of sodium alginate, add 15 ml of distilled water, let it stand still to make it swell, and stir it evenly to form a solution, which is thickener 3;

d) Weigh 1.5g of evening primrose oil, 2g of wheat germ oil, 2g of grape seed oil, 0.3g of simple emulsifier SIMULGEL EG, and 0.5g of olive oil emulsifier, and place them in beaker 1, and place beaker 1 at 75°C Heating in a water bath as an oil phase;

e) Measure 5ml of 1,2-propanediol and 15ml of distilled water into beaker 2, and heat beaker 2 in a water bath at 75°C as the water phase;

f) After the water phase and the oil phase reach the same temperature, pour the water phase in the beaker 2 into the oil phase in a thin stream, and stir while adding until a uniform emulsion matrix is formed;

g) Add 1 g of forget-me-not extract, 1 g of rosemary extract, 1 g of 1,3-butanediol, 2 ml of 7% ethylparaben alcohol solution (75% ethanol) into the emulsion matrix, and stir evenly;

h) Add thickener 1, thickener 2, thickener 3, 1% gel forming agent STABILEZE QM solution 2g into the beaker, and stir evenly to obtain freckle and yellow gel.

Example 2

2.1 Preparation of forget-me-not extract:

Weigh 25g of forget-me-nots and extract in water at 100°C for 3 times, add 25 times the amount of water for the first time, extract for 1.5 hours, use 15 times the amount of water for the second time, extract for 1 hour, add 8 times the amount of water for the third time, extract for 0.5 hours, Filter each time with 3 layers of gauze, combine the filtrates, heat and concentrate to 15 times g/ml of the weight of the forget-me-not, and obtain the forget-me-not extract.

2.2 Preparation of rosemary extract:

Weigh 15g of rosemary, reflux and extract in water at 100°C for 3 times, add 20 times the amount of water for the first time, extract for 1.5h, filter with three layers of gauze, add 15 times the amount of water for the second time, extract for 1h, filter, For the third time, use 10 times the amount of water, extract for 0.5h, filter, combine the three filtrates, heat and concentrate to 10 times the weight of rosemary g/ml, and obtain the rosemary extract.

2.3 The preparation method of freckle-removing and yellow-removing gel

a) Weigh 0.3g of ice crystal forming agent AVC, add 25ml of distilled water, stir to dissolve, and become thickener 1;

b) Weigh carbomer 9410.15g, add 20ml of distilled water, let it stand still to make it swell, stir evenly to form a solution, which is thickener 2;

c) Weigh 0.2 g of sodium alginate, add 20 ml of distilled water, allow it to swell, stir evenly to form a solution, which is thickener 3;

d) Weigh 3g of evening primrose oil, 3g of wheat germ oil, 3g of grape seed oil, 1.0g of simple emulsifier SIMULGEL EG, and 1.0g of olive oil emulsifier, respectively, and put them in beaker 1, and place beaker 1 in a 90°C Heating in a water bath as an oil phase;

e) Measure 9ml of 1,2-propanediol and 10ml of distilled water into beaker 2, and heat beaker 2 in a water bath at 90°C as the water phase;

f) After the water phase and the oil phase reach the same temperature, pour the water phase in the beaker 2 into the oil phase in a thin stream, and stir while adding until a uniform emulsion matrix is formed;

g) Add 1.5g of forget-me-not extract, 1.5g of rosemary extract, 1.5g of 1,3-butanediol, 2ml of 7% ethylparaben alcohol solution (75% ethanol) into the emulsion matrix, and stir evenly ;

h) Add thickener 1, thickener 2, thickener 3, 1% gel forming agent STABILEZE QM solution 2g into the beaker, and stir evenly to obtain freckle and yellow gel.

Example 3

The physicochemical index of embodiment 1,2 is as follows

3.1 Traits

This product is a milky white, transparent and crystal clear gel with suitable viscosity, good stability and fragrant smell.

3.2 pH check

Take this product and measure it with pH test paper, and the pH value is 6-7.

3.3 Hot and cold test

The gel was packaged in a transparent cosmetic bottle and refrigerated in a refrigerator at 4°C for one month to observe no delamination. In a constant temperature box at 55°C for 24 hours, the gel has no phenomenon of stratification and odor change.

3.4 Centrifugal test

The gel was packaged in a stoppered test tube at 3000r/min, and centrifuged for 20min without stratification.

3.5 Placement experiment at room temperature

The gel prepared in Examples 1 and 2 was placed in a cosmetic bottle, and left standing at room temperature for 6 months, no delamination phenomenon, no change in feeling and smell after use.

3.6 Irritation test, allergy test

The hair on the back of the mouse was cut off, and the gels prepared in Examples 1 and 2 were applied to the hair-cut parts respectively, and compared with the uncoated parts, the results showed no irritation and allergic reactions.

Take Example 1 and 2 and apply them on the hands and faces of volunteers (20-50 years old, 40 people), observe after 30 minutes, no redness, rash, and blisters appear.

Example 4

Experiment on the effect of removing freckles and yellowing

Select 100 women in the age group of 20-50 as trial subjects, randomly divide them into two groups, and use the gels prepared in Examples 1 and 2 respectively, twice a day, morning and evening, for three months. Among them, in Example 1, among the 50 cases, 24 cases were under 35 years old, and 26 cases were over 35 years old. Example 2, among 50 cases, 22 cases were under 35 years old, and 28 cases were over 35 years old. The selected women generally have dry and dark yellow skin, different degrees of wrinkles, freckles, and pigmented spots.

Efficacy standard: markedly effective, spots and wrinkles become lighter, lighter or even disappear, the skin is much ruddy, and the aging phenomenon is not obvious; effective, the dark yellow gradually becomes milder, the skin is relatively moist, but the wrinkles and spots are still not reduced; ineffective, the skin The problem has not improved or lightened, and the complexion is still dark yellow and dry. The results are shown in Table 1:

Table 1 Results of freckle and yellow removal experiment

Example 5

Investigation on the Comprehensive Effect of Gel

Next, the effects of the gels produced in Examples 1 and 2 were evaluated by using the test feeling. Adopt public opinion survey scoring method, select 70 people in the age group of 20-50 years old as trial object, divide into two groups arbitrarily, use the gel emulsion prepared in embodiment 1, 2 respectively. 2 times a day, morning and evening, for two months. The total score of each use effect is 5 points: 5 points is the highest score, which means good and very satisfied; 4 points are very good; 3 points are acceptable; below 3 points are bad and unacceptable. The following are the average scores for each item, and the results are shown in Table 2:

Table 2 Comprehensive effect inspection

Effect The average score of each item of embodiment 1 The average score of each item of embodiment 2 light lines 4.6 4.5 moisture retention 4.8 4.7 Nutritious 4.9 4.8 Anti-freckle 4.6 4.5

In summary, the gel prepared by the present invention has very good effects of lightening lines, moisturizing, removing spots and nourishing.

Claims (3)

1. a kind of nti-freckle is dispelled yellow gel, it is characterised in that contain following material in 100g gels：

Evening primrose oil 1-3g

Wheat-germ oil 1-3g

Grape-kernel oil 1-3g

Simple emulsifying agent SIMULGEL EG 0.1-1.0g

Olive emulsifier 0.1-1.0g

1,2- propane diols 1-9ml

Ice crystal forming agent AVC 0.1-0.3g

Carbomer 0.05-0.15g

Sodium alginate 0.02-0.2g

1% gel former STABILEZE QM solution 1-5g

Forget-me-not extract 0.1-2g

Rosemary extract 0.1-2g

1,3 butylene glycol 0.1-2.0g

75% ethanol solution 1-3ml of 7% ethylparaben

Distilled water 45-95ml；

Described nti-freckle is dispelled the preparation method of yellow gel, comprises the following steps：

a）Ice crystal forming agent AVC 0.1-0.3g is weighed, is added 15-25ml distilled water, stirring to dissolve which, is thickener 1；

b）Carbomer 0.05-0.15g is weighed, adds 10-20ml distilled water, standing to make which swelling, stir wiring solution-forming, is Thickener 2；

c）Sodium alginate 0.02-0.2g, plus distilled water 10-20ml are weighed, standing makes which swelling, and stir wiring solution-forming, is Thickener 3；

d）Evening primrose oil 1-3g, wheat-germ oil 1-3g, grape-kernel oil 1-3g, simple emulsifying agent SIMULGEL EG are weighed respectively 0.1-1.0g, olive emulsifier 0.1-1.0g, are placed in beaker 1, beaker 1 is placed in 60-90 DEG C of water-bath and is heated, made For oil phase；

e）Measure 1,2-PD 1-9ml again respectively, distilled water 10-30ml pours beaker 2 into, and beaker 2 is placed on 60-90 DEG C of water Heat in bath, as water phase；

f）Deng water phase and oil phase reach it is mutually synthermal after, water in beaker 2 is mutually poured into oil phase in thread shape, it is stirring while adding, directly To forming uniform emulsion bases；

g）Toward emulsion bases add forget-me-not extract 0.1-2g, rosemary extract 0.1-2g, 1,3 butylene glycol 0.1-2g, 75% ethanol solution 1-3ml of 7% ethylparaben, uniform stirring；

h）Again in beaker add thickener 1, thickener 2, thickener 3,1% gel former STABILEZE QM solution 1-5g, Uniform stirring, obtains final product nti-freckle and dispels yellow gel.

2. nti-freckle according to claim 1 is dispelled yellow gel, it is characterised in that：Described forget-me-not extract is by with lower section It is prepared by method：

Weigh forget-me-not appropriate, 0.5-2h is extracted in refluxing extraction 3 times in 90-100 DEG C of water, the 1st time plus the 5-25 times of water yield, With the 5-20 times of water yield, 0.5-1.5h is extracted 2nd time, the 3rd time plus the 5-10 times of water yield are extracted 0.5-1h, filtered with 3 layers of gauze every time Cross, merging filtrate, heating concentration, in terms of mL/g, filtrate volume is concentrated into 5-20 times of forget-me-not weight, obtains final product forget-me-not and carries Take liquid.

3. nti-freckle according to claim 1 is dispelled yellow gel, it is characterised in that：Described rosemary extract is by with lower section It is prepared by method：

The rosemary of constant weight is weighed, refluxing extraction 3 times in 90-100 DEG C of water add 5-25 times for the first time and measure water, extract 0.5-2h, with three layers of filtered through gauze, adds 5-20 times for the second time and measures water, extract 0.5-1.5h, filter, measured with 5-15 times for the third time Water, extracts 0.2-1h, filters, and mixes three filtrates, and heating is concentrated, and in terms of mL/g, filtrate volume is concentrated into rosemary weight 5-15 times, that is, obtain rosemary extract.