CN105796457B - A kind of scar anti-acne print lotion and preparation method thereof of dispelling rich in natural extract - Google Patents
A kind of scar anti-acne print lotion and preparation method thereof of dispelling rich in natural extract Download PDFInfo
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- CN105796457B CN105796457B CN201610141353.2A CN201610141353A CN105796457B CN 105796457 B CN105796457 B CN 105796457B CN 201610141353 A CN201610141353 A CN 201610141353A CN 105796457 B CN105796457 B CN 105796457B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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Abstract
本发明公开了一种富含天然提取物的祛疤祛痘印乳液及其制备方法,所述乳液中含有以下物质:芦荟油、杏仁油、金盏花油、沙棘油、马油、鸸鹋油、甘油、1%透明质酸钠溶液、丹参提取液、白僵蚕提取液、桃仁提取液、积雪草提取液、D‑泛酰醇、ML乳化剂、橄榄乳化剂、蒸馏水、硅油、海藻酸钠、阳离子瓜尔胶、复方抗菌剂、香精。本发明与现有技术相比,本乳呈淡黄色,稠度适宜,轻盈水润,细腻均匀,涂展性良好,气味芬芳,有效成分绿色纯天然,其中所含透明质酸钠具有软化、缓解疤痕形成的功能,其有效成分能够深入真皮层,分解、清除和代替各种老化、纤维化的受损无功能的疤痕组织,给具有再生潜能的上皮细胞准备好空间。The invention discloses a scar-removing and acne-removing emulsion rich in natural extracts and a preparation method thereof. The emulsion contains the following substances: aloe vera oil, almond oil, calendula oil, seabuckthorn oil, horse oil, emu Oil, glycerin, 1% sodium hyaluronate solution, salvia miltiorrhiza extract, white muscadine silkworm extract, peach kernel extract, centella asiatica extract, D-panthenol, ML emulsifier, olive emulsifier, distilled water, silicone oil, Sodium alginate, cationic guar gum, compound antibacterial agent, essence. Compared with the prior art, the present invention has light yellow color, suitable consistency, light and moist, fine and uniform, good spreadability, fragrant smell, green and natural active ingredients, and sodium hyaluronate contained therein has the functions of softening, relieving The function of scar formation, its active ingredients can penetrate deep into the dermis, decompose, remove and replace various aging, fibrotic, damaged and non-functional scar tissues, and prepare space for epithelial cells with regenerative potential.
Description
技术领域technical field
本发明涉及一种乳液,尤其涉及一种富含天然成分提取物的祛疤祛痘印乳液及其制备方法。The invention relates to an emulsion, in particular to an emulsion rich in natural component extracts for removing scars and acne marks and a preparation method thereof.
背景技术Background technique
爱美是人的天性,每个人都希望自己拥有光滑细腻的肌肤,但是总会有不小心弄伤皮肤后留下疤痕的情况,或者是青春期的痘痘消退后留下的痘印,总是让我们苦恼不已,有些甚至会伴随我们一生,对我们的工作生活产生或多或少的影响。It is human nature to love beauty. Everyone hopes to have smooth and delicate skin, but there will always be scars left after accidentally injuring the skin, or the acne marks left after the acne in adolescence subsides. It makes us distressed, and some will even accompany us for a lifetime, and have more or less impact on our work and life.
然而目前市面上销售的乳液仅仅起到美白或者保湿的效果,一些祛疤祛痘印的药膏作用效果也不是很明确,且均为药效型,而我们的祛疤祛痘印乳液是兼具营养和药效的,所用材料均为极好的的美容材料,取自大自然,纯天然无污染,在祛疤祛痘印的同时有滋养、美白、保湿的作用,为皮肤提供充足的营养,可以作为护肤的乳液长期使用。However, the lotions currently on the market only have the effect of whitening or moisturizing, and some ointments for removing scars and acne marks are not very clear, and they are all medicinal effects. In terms of nutrition and medicinal effect, the materials used are all excellent beauty materials, taken from nature, pure natural and pollution-free, it can nourish, whiten and moisturize the skin while removing scars and acne marks, and provide sufficient nutrition for the skin , can be used as a skin care lotion for a long time.
据调查许多厂商在利益的驱使下,为了能让产品有更好的美白功效,提高销量,开始在化妆品、护肤品中添加一些对皮肤有害的化学合成物质,忽略了安全有效的原则。其实,一些天然存在的植物成分,大多富含改善皮肤的活性成分,在改善疤痕痘印的同时可以延缓衰老,此类新型产品可有效缓解当前化妆品市场的严峻形式,符合当下潮流,使用安全放心。According to the survey, many manufacturers, driven by profit, began to add some chemical synthetic substances harmful to the skin in cosmetics and skin care products in order to make their products have better whitening effect and increase sales, ignoring the principle of safety and effectiveness. In fact, some naturally occurring plant ingredients are mostly rich in skin-improving active ingredients, which can delay aging while improving scars and acne marks. This new type of product can effectively alleviate the severe situation in the current cosmetics market, conforms to the current trend, and is safe to use .
在绿色产品理念的推动下,天然化妆品成为一种时尚,是今后国内外化妆品研发的最主要趋势。中草药原材料资源丰富,品种繁多,使用方便,其发展前景十分的广阔,市场上对含有植物天然活性成分的营养型和药效型精华乳液有巨大需求,此款乳液的研发推出正好满足了当下的需求。Driven by the concept of green products, natural cosmetics have become a fashion, which is the main trend of cosmetics research and development at home and abroad in the future. Chinese herbal medicine is rich in raw material resources, various in variety, and easy to use. Its development prospects are very broad. There is a huge demand for nutritional and medicinal essence emulsions containing natural plant active ingredients in the market. The development and launch of this emulsion just meets the current needs. need.
发明内容Contents of the invention
发明目的:本发明的目的是提供一种新的富含天然成分提取物的祛疤祛痘印乳液。Purpose of the invention: the purpose of the present invention is to provide a new scar-removing and acne-removing emulsion rich in natural component extracts.
技术方案:为了实现上述发明目的,本发明采用的技术方案如下:Technical solution: In order to realize the above-mentioned purpose of the invention, the technical solution adopted in the present invention is as follows:
一种富含天然成分提取物的祛疤祛痘印乳液,其特征在于:乳液中包含有下述配比的原料组分:An emulsion for removing scars and acne marks rich in natural component extracts, characterized in that: the emulsion contains the following raw material components:
所述的丹参提取液是通过以下方法制备:Described salvia miltiorrhiza extract is prepared by the following method:
称取丹参适量,浸泡0.15-1h,加热至90-100℃,煎煮提取3次,第一次加6-12倍量的水,提取0.5-2h,第二次加4-10倍量的水,提取0.5-1.5h,第三次加3-8倍量水,提取0.5-1.5h,每次滤过,合并滤液,滤液的体积浓缩至丹参重量的3-6倍g/ml,过滤即得。Weigh an appropriate amount of Salvia miltiorrhiza, soak for 0.15-1h, heat to 90-100°C, decoct and extract 3 times, add 6-12 times the amount of water for the first time, extract for 0.5-2h, add 4-10 times the amount for the second time Water, extract for 0.5-1.5h, add 3-8 times the amount of water for the third time, extract for 0.5-1.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 3-6 times the weight of Danshen g/ml, filter Instantly.
所述白僵蚕提取液是通过以下方法制备:The white silkworm extract is prepared by the following method:
称取白僵蚕适量,加热至90-100℃,煎煮提取3次,第一次加4-10倍量的水,提取0.5-2h,第二次加4-10倍量的水,提取0.5-1.5h,第三次加3-8倍量的水,提取0.5-1.5h,每次滤过,合并滤液,滤液体积浓缩至白僵蚕重量的3-7倍g/ml,过滤即得。Weigh an appropriate amount of white silkworm, heat to 90-100°C, decoct and extract 3 times, add 4-10 times the amount of water for the first time, extract for 0.5-2 hours, add 4-10 times the amount of water for the second time, extract 0.5-1.5h, add 3-8 times the amount of water for the third time, extract for 0.5-1.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 3-7 times the weight of the silkworm, g/ml, and filter have to.
所述桃仁提取液是通过以下方法制备:The peach kernel extract is prepared by the following method:
称取桃仁粗粉适量,加热至90-100℃,煎煮提取2次,第一次加5-11倍量的水,提取0.5-2h,第二次加4-10倍量的水,提取0.5-2h,两次过滤,合并滤液,滤液体积浓缩至桃仁重量的3-6倍g/ml,过滤即得。Weigh an appropriate amount of peach kernel powder, heat to 90-100°C, decoct and extract twice, add 5-11 times the amount of water for the first time, extract for 0.5-2h, add 4-10 times the amount of water for the second time, extract 0.5-2h, filter twice, combine the filtrate, concentrate the volume of the filtrate to 3-6 times the weight of the peach kernel g/ml, and filter to obtain.
所述积雪草提取液是通过以下方法制备:The centella asiatica extract is prepared by the following method:
称取积雪草适量,剪碎,浸泡0.15-1h,加热至90-100℃,煎煮提取3次,第一次加8-15倍量的水,提取0.5-2h,第二次加4-10倍量的水,提取0.5-1.5h,第三次加3-8倍的水提取0.5-1.5h,每次过滤,合并滤液,滤液体积浓缩至积雪草重量的4-8倍g/ml,过滤即得。Weigh an appropriate amount of Centella asiatica, cut it into pieces, soak for 0.15-1h, heat to 90-100°C, decoct and extract 3 times, add 8-15 times the amount of water for the first time, extract for 0.5-2h, and add 4 for the second time -10 times the amount of water, extract for 0.5-1.5h, add 3-8 times of water for the third time and extract for 0.5-1.5h, filter each time, combine the filtrate, and concentrate the volume of the filtrate to 4-8 times the weight of Centella asiatica /ml, obtained by filtration.
所述的香精为柠檬香精、玫瑰香精、青瓜香精、水蜜桃香精、百合香精、菠萝香精、桂花香精一种或几种。The essence is one or more of lemon essence, rose essence, cucumber essence, peach essence, lily essence, pineapple essence, and sweet-scented osmanthus essence.
所述的一种富含天然成分提取物的祛疤祛痘印乳液的制备方法,包括以下步骤:The preparation method of the described scar-removing and acne-removing lotion rich in natural component extracts comprises the following steps:
a)称取海藻酸钠0.01-0.1g,加水1-9.9ml,静置过夜后搅拌均匀即得海藻酸钠凝胶液a;a) Weigh 0.01-0.1 g of sodium alginate, add 1-9.9 ml of water, let stand overnight and stir evenly to obtain sodium alginate gel liquid a;
b)称取阳离子瓜耳胶0.02-0.2g,加水1-9.8ml,静置过夜后搅拌均匀即得阳离子瓜尔胶凝胶液b;b) Weigh 0.02-0.2 g of cationic guar gum, add 1-9.8 ml of water, and stir evenly after standing overnight to obtain cationic guar gum gel liquid b;
c)称取D-泛酰醇0.5-3g,加水0.8-5ml,搅拌溶解得D-泛酰醇溶液c;c) Weigh 0.5-3 g of D-panthenol, add 0.8-5 ml of water, stir and dissolve to obtain D-panthenol solution c;
d)称取芦荟油0.5-2g,杏仁油1-3g,金盏花油0.5-3g,沙棘油0.5-2g,马油1-4g,鸸鹋油0.1-2g,ML乳化剂2-4g,橄榄乳化剂2-4g于小烧杯中,置水浴锅上,保持温度60-90℃,水浴加热,溶化,混匀,作为油相;d) Weigh 0.5-2g aloe vera oil, 1-3g almond oil, 0.5-3g calendula oil, 0.5-2g seabuckthorn oil, 1-4g horse oil, 0.1-2g emu oil, 2-4g ML emulsifier, Put 2-4g of olive emulsifier in a small beaker, put it on a water bath, keep the temperature at 60-90°C, heat in a water bath, melt, mix well, and use it as the oil phase;
e)量取蒸馏水10-25ml于烧杯中,置水浴锅上,保持温度60-90℃,水浴加热,作为水相;e) Measure 10-25ml of distilled water in a beaker, place it on a water bath, keep the temperature at 60-90°C, heat it in a water bath, and use it as the water phase;
f)待烧杯中油相完全熔融,将同温的烧杯中的水相缓缓倒入油相中,边加边向同一方向搅拌10-15min,至呈均匀淡黄色乳状基质,从水浴锅中拿出并冷却至室温;f) After the oil phase in the beaker is completely melted, slowly pour the water phase in the beaker at the same temperature into the oil phase, and stir in the same direction for 10-15 minutes while adding, until it becomes a uniform light yellow milky matrix, take it from the water bath out and cool to room temperature;
g)待基质放冷后加入甘油0.5-2g、1%透明质酸钠溶液0.1-2g、D-泛酰醇溶液c、丹参提取液0.5-2g、白僵蚕提取液0.5-2g、桃仁提取液0.5-2g、积雪草提取液0.5-2g,搅拌均匀,最后加入硅油0.1-2g,搅拌均匀;g) After cooling the matrix, add 0.5-2g of glycerin, 0.1-2g of 1% sodium hyaluronate solution, D-panthenol solution c, 0.5-2g of Salvia miltiorrhiza extract, 0.5-2g of white silkworm extract, and peach kernel extract Liquid 0.5-2g, centella asiatica extract 0.5-2g, stir evenly, finally add silicone oil 0.1-2g, stir evenly;
h)所得的乳剂基质中加入已经溶胀完全的海藻酸钠凝胶液a和阳离子瓜耳胶凝胶液b,搅拌5-10min,混合均匀得乳液g;h) adding fully swollen sodium alginate gel liquid a and cationic guar gum gel liquid b to the obtained emulsion matrix, stirring for 5-10 min, and mixing uniformly to obtain emulsion g;
i)向乳液g中加入抗菌剂0.5-3ml,香精0.05-0.3ml,搅拌均匀即得祛疤祛痘印乳液。i) Add 0.5-3ml of antibacterial agent and 0.05-0.3ml of essence to the emulsion g, and stir evenly to obtain the emulsion for removing scars and acne marks.
本发明的各种成分如下:The various components of the present invention are as follows:
芦荟油所含的纯油性芦荟凝液,能给予灼伤、擦伤以及日晒后失去水份的肌肤更深层的滋润与养份,并迅速修复受损的细胞组织,促使细胞再生,并使肌肤恢复健康,具有滋润保湿、美白祛斑、抗衰老、防过敏等直接美容效果。同时起到抑制皮肤表面致病微生物、细菌,杀死对人体皮肤有害的螨虫,防止体表微生物的繁殖,预防皮肤病的发生。适合油性皮肤,平衡、抑制皮脂分泌,促进伤口愈合。The pure oily aloe gel contained in aloe vera oil can give deeper moisture and nutrients to the skin that has lost moisture after burns, abrasions and sun exposure, and quickly repair damaged cell tissues, promote cell regeneration, and make the skin It restores health and has direct cosmetic effects such as moisturizing, whitening and freckle removal, anti-aging, and anti-allergic. At the same time, it can inhibit pathogenic microorganisms and bacteria on the surface of the skin, kill mites harmful to human skin, prevent the reproduction of microorganisms on the surface of the body, and prevent the occurrence of skin diseases. Suitable for oily skin, balances, inhibits sebum secretion, and promotes wound healing.
杏仁油富含矿物质、蛋白质及各种维他命,易吸收,是一种天然的润湿剂,具有滋养与保湿、舒缓与抗过敏的作用,是一种保养皮肤及滋润效果极佳的植物油,对于干性皮肤或因气候变化而引起皮肤不适问题极有益处,可促进细胞生长,适合干燥、敏感、发炎及无光泽的肌肤。它能有效地减轻皮肤发痒现象,消除红肿、干燥和发炎。对于运动过度引起之肌肉疼痛,可加强细胞带氧功能,消除疲劳与碳酸累积,具有镇痛及减轻刺激的作用,可刺激内分泌系统的脑下垂体、胸腺和肾上腺,促进细胞更新。Almond oil is rich in minerals, proteins and various vitamins. It is easy to absorb. It is a natural wetting agent with nourishing and moisturizing, soothing and anti-allergic effects. It is a vegetable oil with excellent skin care and moisturizing effects. It is very beneficial for dry skin or skin discomfort caused by climate change. It can promote cell growth and is suitable for dry, sensitive, inflamed and dull skin. It effectively relieves itchy skin and eliminates redness, dryness and inflammation. For muscle pain caused by excessive exercise, it can strengthen the oxygen-carrying function of cells, eliminate fatigue and carbonic acid accumulation, relieve pain and reduce irritation, stimulate the pituitary gland, thymus and adrenal glands of the endocrine system, and promote cell renewal.
金盏花油拥有超强的愈合能力,具有杀菌、收敛伤口的效果,可以有效治理发炎、暗疮、毛孔粗大等肌肤问题,同时可以镇定肌肤,改善敏感性肤质,具有修护疤痕的功效。金盏花油可以用来滋润干燥的唇部,促进皮肤的新陈代谢,超强的滋润效果对于干燥肌肤疗效显著。金盏花油还具有优异的抗氧化功效,能消除自由基对细胞的伤害,具有抗自由基及强化细胞增殖的功效,促进细胞再生。Calendula oil has super healing ability, has the effect of sterilizing and astringing wounds, and can effectively treat skin problems such as inflammation, acne, and enlarged pores. At the same time, it can calm the skin, improve sensitive skin, and have the effect of repairing scars. Calendula oil can be used to moisturize dry lips and promote skin metabolism. The super moisturizing effect has a significant effect on dry skin. Calendula oil also has excellent anti-oxidation effects, can eliminate free radical damage to cells, has the effect of resisting free radicals and strengthening cell proliferation, and promotes cell regeneration.
沙棘油能快速打通微循环,其所富含的沙棘黄酮、胡萝卜素、类胡萝卜素、磷脂类化合物、维生素E、矿物质硒都具有极强的抗氧化和直接捕捉自由基作用,并能分解、代谢血中垃圾和毒素,修复皮肤细胞,改善皮肤的代谢。另外,沙棘中的维生素C含量又号称“果蔬之王”,不但具有极强的抗氧化作用,在体内可以储存,又具有美白肌肤的功效。Seabuckthorn oil can quickly open up the microcirculation, and its rich seabuckthorn flavonoids, carotene, carotenoids, phospholipids, vitamin E, and mineral selenium all have strong anti-oxidation and direct capture of free radicals, and can decompose , Metabolize garbage and toxins in the blood, repair skin cells, and improve skin metabolism. In addition, the vitamin C content in seabuckthorn is also known as the "king of fruits and vegetables". It not only has a strong antioxidant effect, can be stored in the body, but also has the effect of whitening the skin.
马油的主要组份为油酸、亚油酸和棕榈酸,其中油酸和亚油酸总含量为50%。因为马油和人的皮下脂肪成分相似,有利于皮肤的吸收渗透,所以具有很好的保湿效果,可以用做化妆打底和脸部、身体的保养,另外还具有抑制色斑,缓解皮炎和烫伤、预防冻伤、雀斑、手脚冻裂等皮肤疾病,对神经痛、肌肉痛及半身不遂而引起的颜面麻痹也很有效。马油里含有的营养素(维他命E和亚麻酸)能恢复肌体健康和使肌肤柔嫩,并且可加强对疾病的免疫力和抵抗力,可防止皮肤老化、抑制黑色素沉淀。The main components of horse oil are oleic acid, linoleic acid and palmitic acid, wherein the total content of oleic acid and linoleic acid is 50%. Because the composition of horse oil is similar to that of human subcutaneous fat, it is beneficial to the absorption and penetration of the skin, so it has a good moisturizing effect and can be used as a makeup primer and maintenance of the face and body. In addition, it can inhibit pigmentation, relieve dermatitis and Burns, prevention of frostbite, freckles, cracked hands and feet and other skin diseases, also very effective for facial paralysis caused by neuralgia, muscle pain and hemiplegia. The nutrients (vitamin E and linolenic acid) contained in horse oil can restore the health of the body and make the skin soft, and can strengthen immunity and resistance to diseases, prevent skin aging, and inhibit melanin deposition.
鸸鹋油是由鸸鹋的脂肪提炼而成,渗入人的皮肤后,可加速皮肤细胞的新陈代谢、促进血液循环、活化细胞组织、促进皮肤再生、加速伤口愈合、消除皮肤炎症、辅助防治皮肤癌等,被澳洲土著人称为神油。鸸鹋油具有促进创面愈合,护肤美容以及改善人体循环系统功能等作用。鸸鹋油与人类皮肤的油脂有极为相似的脂肪酸组成,具有很强的皮肤渗透力,减轻炎性水肿,有消炎、促进伤口愈合的功能。作为一种润滑剂,能抑制疤痕的产生。鸸鹋油能活化细胞,促进细胞组织的新陈代谢,使皮肤中的废物及时排泄,不易沉淀形成色斑,并使已在表皮形成的色斑淡化消退,增强皮肤细胞再生,使成纤维细胞增殖,透明质酸增加,皮肤内含水量增加,皮肤皱纹减少,肤色白里透红。Emu oil is extracted from emu fat. After infiltrated into human skin, it can accelerate the metabolism of skin cells, promote blood circulation, activate cell tissue, promote skin regeneration, accelerate wound healing, eliminate skin inflammation, and help prevent and treat skin cancer etc., are called the god oil by the Australian Aboriginal people. Emu oil has the functions of promoting wound healing, skin care and beauty, and improving the function of human circulatory system. Emu oil has a very similar fatty acid composition to human skin oil, which has strong skin penetration, reduces inflammatory edema, and has the functions of anti-inflammatory and promoting wound healing. Acts as a lubricant to inhibit the appearance of scars. Emu oil can activate cells, promote the metabolism of cell tissues, excrete waste in the skin in time, prevent the formation of stains, and fade and fade the stains that have formed on the epidermis, enhance skin cell regeneration, and make fibroblasts proliferate. Hyaluronic acid increases, the water content in the skin increases, skin wrinkles decrease, and the complexion is rosy.
丹参能够有效抑制皮肤脂质氧化,改善局部微循环。所含的丹参酮、丹酚酸被毛孔吸收之后,能够刺激皮下的血液循环,同时抑制脂质氧化反应,消除由于血液循环不畅而导致的痤疮、暗疮、色斑,调节水油平衡。丹参水溶性提取物具有独特宜人的天然清香气,是美容护肤用品的理想天然原料,可通过促进体表微循环,使肌肤得到充分的濡润和营养,使人面色红润有光泽,瘀斑消退,延缓衰老。Danshen can effectively inhibit skin lipid oxidation and improve local microcirculation. The tanshinone and salvianolic acid contained in it can stimulate the blood circulation under the skin after being absorbed by the pores, and at the same time inhibit the lipid oxidation reaction, eliminate acne, pimples, and spots caused by poor blood circulation, and regulate the water-oil balance. Salvia miltiorrhiza water-soluble extract has a unique and pleasant natural fragrance. It is an ideal natural raw material for beauty and skin care products. It can fully moisten and nourish the skin by promoting the microcirculation of the body surface, making the complexion ruddy and shiny, and the ecchymosis subsided ,anti aging.
白僵蚕在《神农本草经》中载有:“灭黑斑,令人面色好”的功效。通过白僵蚕来进行美容去斑时,可采用外用法,也可使用内服法。外用时,将白僵蚕研成粉末,与蜂蜜调和成膏状,洁面后涂抹适量进行敷面,有不错的祛斑效果。内服时,可与白茯苓、白菊花、玫瑰花、丝瓜络等一起入锅煎汁,可美白、祛斑、祛疤痕、治疗面部色斑、祛风润肤,临床上用于美白、祛汗斑、瘢痕疙瘩、粉刺等。White silkworm is recorded in "Shen Nong's Materia Medica": "eliminating dark spots, making people look good". When the white silkworm is used for beauty and speckle removal, it can be used externally or internally. For external use, grind white silkworm into powder, mix it with honey to form a paste, apply an appropriate amount on the face after cleansing, it has a good effect of removing freckles. When taken orally, it can be boiled together with white tuckahoe, white chrysanthemum, rose, loofah, etc., to whiten, remove freckles, remove scars, treat facial pigmentation, dispel wind and moisturize the skin. It is clinically used for whitening, removing sweat spots, Keloids, acne, etc.
桃仁有活血祛瘀、抗炎、抗过敏、改善微循环的作用,可活血祛斑,润肤祛皴。《名医别录》即有本品“悦泽人面”之记载。《食疗本草》更有“每夜嚼一颗,和蜜涂于面良”的具体用法。本品为血瘀之面斑、粉刺、酒渣鼻,以及皮肤干涩、皴皱、皲裂常用之品。《御药院方》:“去皴皱,悦皮肤。”桃仁水煎剂及提取物有抗炎、抗菌、抗过敏作用。Peach kernel has the effects of promoting blood circulation and removing blood stasis, anti-inflammation, anti-allergy, improving microcirculation, promoting blood circulation and removing freckles, moisturizing skin and removing chapped skin. There is a record of this product as "Yueze Renmian" in "Famous Doctors". "Diet Therapeutic Materia Medica" has a specific usage of "chewing one every night and applying it with honey". This product is commonly used for blood stasis, acne, rosacea, and dry, wrinkled, chapped skin. "Yuyaoyuanfang": "Remove chapped wrinkles and delight the skin." Peach kernel water decoction and extracts have anti-inflammatory, antibacterial, and anti-allergic effects.
积雪草萃取物可以紧致表皮与真皮连接部,能使皮肤变柔软,帮助促进真皮层中胶原蛋白新生,有令肌肤紧致的效果,还可帮助受损的组织愈合,抑制脂肪细胞的增添,预防皮肤水肿。Centella asiatica extract can tighten the junction between the epidermis and the dermis, soften the skin, help promote the regeneration of collagen in the dermis, have a firming effect on the skin, help the damaged tissue heal, and inhibit the growth of fat cells Add to prevent skin edema.
D-泛酰醇又被称为“维生素原B5”(即维生素B5的前体)是保湿剂、柔软剂,易氧化,促进皮肤正常角化,促进伤口愈合和皮肤组织修复,刺激细胞分裂再生,对疤痕愈合非常有效。D-panthenol, also known as "provitamin B 5 " (the precursor of vitamin B 5 ), is a moisturizer, softener, easy to oxidize, promote normal keratinization of the skin, promote wound healing and skin tissue repair, and stimulate cells Split regeneration, very effective for scar healing.
透明质酸能改善皮肤生长条件,为真皮胶原蛋白和弹性纤维的合成提供优越的外部环境,加强营养物质的供给,起到护肤养颜的效果。研究表明,透明质酸可以阻止细胞中一些酶的产生,减少自由基的形成,在防止自由基破坏细胞结构、产生脂质过氧化和引起肌体衰老等方面起着重要作用。透明质酸具有抗炎、抑制病菌产生、保持皮肤光洁的作用;为细胞增殖与分化提供合适的场所,直接促进细胞生长、分化、重建与修复等。Hyaluronic acid can improve skin growth conditions, provide a superior external environment for the synthesis of dermal collagen and elastic fibers, strengthen the supply of nutrients, and have the effect of skin care and beauty. Studies have shown that hyaluronic acid can prevent the production of some enzymes in cells, reduce the formation of free radicals, and play an important role in preventing free radicals from damaging cell structures, producing lipid peroxidation, and causing body aging. Hyaluronic acid has the functions of anti-inflammation, inhibiting the production of germs, and keeping the skin smooth; it provides a suitable place for cell proliferation and differentiation, and directly promotes cell growth, differentiation, reconstruction and repair.
总之,本乳液具有可消除氧自由基的作用,抑制色斑的产生,对抗皮肤衰老,能补充肌肤需要的营养、水分,调节皮肤免疫功能,增强皮肤抵御外界刺激,改善皮肤血液循环,促进新陈代谢,软化、缓解疤痕形成的功能,其有效成分能够深入真皮层,分解、清除和代替各种老化、纤维化的受损无功能的疤痕组织,给具有再生潜能的上皮细胞准备好空间。In short, this lotion has the function of eliminating oxygen free radicals, inhibiting the generation of spots, resisting skin aging, supplementing the nutrition and moisture needed by the skin, regulating skin immune function, enhancing skin resistance to external stimuli, improving skin blood circulation, and promoting metabolism , softening and relieving scar formation, its active ingredients can penetrate deep into the dermis, decompose, remove and replace various aging, fibrotic, damaged and non-functional scar tissues, and prepare space for epithelial cells with regenerative potential.
本发明所制成的乳液粘稠度适宜,轻盈水润,细腻均匀,涂展性良好,气味芬芳。The emulsion prepared by the invention has suitable viscosity, is light and moist, fine and uniform, has good spreadability and has a fragrant smell.
具体实施方式Detailed ways
下面结合具体实施例对本发明作更进一步的说明。The present invention will be further described below in conjunction with specific examples.
本发明的芦荟油、杏仁油、金盏花油、沙棘油、马油、鸸鹋油、ML乳化剂、橄榄乳化剂、复方抗菌剂均由北京信诺久恒科贸有限公司提供。The aloe vera oil, almond oil, calendula oil, seabuckthorn oil, horse oil, emu oil, ML emulsifier, olive emulsifier, and compound antibacterial agent of the present invention are all provided by Beijing Xinnuo Jiuheng Technology and Trade Co., Ltd.
实施例1Example 1
1.1丹参提取液的制备1.1 Preparation of Salvia Miltiorrhiza Extract
称取丹参20g,浸泡0.5h,加热至100℃,煎煮提取3次,第一次加10倍量的水,提取1h,第二次加8倍量的水,提取0.5h,第三次加8倍量水,提取0.5h,每次滤过,合并滤液,滤液的体积浓缩至70ml,过滤即得。Weigh 20g of Salvia miltiorrhiza, soak for 0.5h, heat to 100°C, decoct and extract 3 times, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 0.5h, and extract for the third time Add 8 times the amount of water, extract for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 70ml, and filter to obtain.
1.2白僵蚕提取液的制备1.2 Preparation of silkworm extract
称取白僵蚕20g,加热至100℃,煎煮提取3次,第一次加10倍量的水,提取1h,第二次加8倍量的水,提取1h,第三次加8倍量的水,提取0.5h,每次滤过,合并滤液,滤液体积浓缩至70ml,过滤即得。Weigh 20g of white silkworm, heat to 100°C, decoct and extract 3 times, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, and add 8 times the amount for the third time amount of water, extract for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 70ml, and filter to obtain.
1.3桃仁提取液的制备1.3 Preparation of peach kernel extract
称取桃仁粗粉20g,加热至100℃,煎煮提取2次,第一次加10倍量的水,提取1h,第二次加8倍量的水,提取1h,两次过滤,合并滤液,滤液体积浓缩至100ml,过滤即得。Weigh 20g of peach kernel powder, heat to 100°C, decoct and extract twice, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, filter twice, and combine the filtrates , the volume of the filtrate was concentrated to 100ml, and filtered.
1.4积雪草提取液的制备1.4 Preparation of Centella Asiatica Extract
称取积雪草30g,剪碎,浸泡0.5h,加热至100℃,煎煮提取3次,第一次加13倍量的水,提取1h,第二次加10倍量的水,提取1h,第三次加8倍的水提取0.5h,每次过滤,合并滤液,滤液体积浓缩至130ml,过滤即得。Weigh 30g Centella asiatica, cut into pieces, soak for 0.5h, heat to 100°C, decoct and extract 3 times, add 13 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time, extract for 1 hour , add 8 times of water for the third extraction for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 130ml, and filter to obtain.
1.5祛疤祛痘印乳液的制备1.5 Preparation of Scar Removing and Acne Printing Emulsion
a)称取海藻酸钠0.07g,加水7.0ml,静置过夜后搅拌均匀即得海藻酸钠凝胶液a;a) Weigh 0.07g of sodium alginate, add 7.0ml of water, let stand overnight and stir evenly to obtain sodium alginate gel liquid a;
b)称取阳离子瓜尔胶0.14g,加水6.9ml,静置过夜后搅拌均匀即得阳离子瓜耳胶凝胶液b;b) Take by weighing 0.14g of cationic guar gum, add 6.9ml of water, stir evenly after standing overnight to obtain cationic guar gum gel liquid b;
c)称取D-泛酰醇1g,加水2ml,搅拌溶解得D-泛酰醇溶液c;c) Weigh 1 g of D-panthenol, add 2 ml of water, stir and dissolve to obtain D-panthenol solution c;
d)称取芦荟油1g,杏仁油1g,金盏花油1g,沙棘油1g,精制马油1g,鸸鹋油1g,ML乳化剂1.5g,橄榄乳化剂2g于小烧杯中,置水浴锅上,保持温度80℃,水浴加热,溶化,混匀;d) Weigh 1g of aloe vera oil, 1g of almond oil, 1g of calendula oil, 1g of seabuckthorn oil, 1g of refined horse oil, 1g of emu oil, 1.5g of ML emulsifier, and 2g of olive emulsifier in a small beaker, and place in a water bath On, keep the temperature at 80°C, heat in a water bath, dissolve, and mix well;
e)量取蒸馏水20ml于烧杯中,置水浴锅上,保持温度80℃,水浴加热;e) Measure 20ml of distilled water in a beaker, place it on a water bath, keep the temperature at 80°C, and heat it in a water bath;
f)待烧杯中油相完全熔融,将同温的烧杯中的水相缓缓倒入油相中,边加边向同一方向搅拌15min,至呈均匀淡黄色乳状固体,从水浴锅中拿出并冷却至室温;f) After the oil phase in the beaker is completely melted, slowly pour the water phase in the beaker at the same temperature into the oil phase, and stir in the same direction for 15 minutes while adding, until it becomes a uniform light yellow milky solid, take it out from the water bath and mix Cool to room temperature;
g)待基质放冷后加入甘油1g、1%透明质酸钠(分子量为20-40万)1g、D-泛酰醇溶液c、丹参提取液0.8g、白僵蚕提取液1g、桃仁提取液1g、积雪草提取液1.5g,依次搅拌均匀后加入下一项,最后加入硅油0.7g,搅拌均匀;g) After cooling the matrix, add 1g of glycerin, 1% sodium hyaluronate (molecular weight: 200,000-400,000) 1g, D-panthenol solution c, 0.8g of Salvia miltiorrhiza extract, 1g of white silkworm extract, and peach kernel extract Liquid 1g, Centella asiatica extract 1.5g, stir in turn evenly, then add the next item, finally add 0.7g of silicone oil, stir evenly;
h)所得的乳加入已经溶胀完全的海藻酸钠凝胶液a和阳离子瓜耳胶液b,搅拌10min混合均匀,即得乳剂g;h) Add the obtained milk to the fully swollen sodium alginate gel solution a and cationic guar gum solution b, stir for 10 minutes and mix evenly to obtain emulsion g;
i)向乳剂g中加入复方抗菌剂2ml,玫瑰香精2滴(0.1ml),搅拌均匀即得。i) Add 2ml of compound antibacterial agent and 2 drops (0.1ml) of rose essence to emulsion g, and stir evenly.
实施例2Example 2
2.1丹参提取液的制备2.1 Preparation of Salvia Miltiorrhiza Extract
称取丹参30g,浸泡0.5h,加热至100℃,煎煮提取3次,第一次加11倍量的水,提取1h,第二次加9倍量的水,提取1h,第三次加8倍量水,提取0.5h,每次滤过,合并滤液,滤液的体积浓缩至120ml,过滤即得。Weigh 30g of Salvia miltiorrhiza, soak for 0.5h, heat to 100°C, decoct and extract 3 times, add 11 times the amount of water for the first time, extract for 1 hour, add 9 times the amount of water for the second time, extract for 1 hour, and add 8 times the amount of water, extract for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 120ml, and filter to obtain.
2.2白僵蚕提取液的制备2.2 Preparation of silkworm extract
称取白僵蚕30g,加热至100℃,煎煮提取3次,第一次加10倍量的水,提取1h,第二次加8倍量的水,提取1h,第三次加8倍量的水,提取0.5h,每次滤过,合并滤液,滤液体积浓缩至90ml,过滤即得。Weigh 30g of white silkworm, heat to 100°C, decoct and extract 3 times, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, and add 8 times for the third time amount of water, extract for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 90ml, and filter to obtain.
2.3桃仁提取液的制备2.3 Preparation of peach kernel extract
称取桃仁粗粉25g,加热至100℃,煎煮提取2次,第一次加10倍量的水,提取1h,第二次加8倍量的水,提取1h,两次过滤,合并滤液,滤液体积浓缩至90ml,过滤即得。Weigh 25g of peach kernel powder, heat to 100°C, decoct and extract twice, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, filter twice, and combine the filtrates , the volume of the filtrate was concentrated to 90ml, and filtered.
2.4积雪草提取液的制备2.4 Preparation of Centella Asiatica Extract
称取积雪草40g,剪碎,浸泡0.5h,加热至100℃,煎煮提取3次,第一次加15倍量的水,提取1h,第二次加9倍量的水,提取1h,第三次加8倍的水提取0.5h,每次过滤,合并滤液,滤液体积浓缩至170ml,过滤即得。Weigh 40g Centella asiatica, cut into pieces, soak for 0.5h, heat to 100°C, decoct and extract 3 times, add 15 times the amount of water for the first time, extract for 1 hour, add 9 times the amount of water for the second time, extract for 1 hour , add 8 times of water for the third extraction for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 170ml, and filter to obtain.
2.5祛疤祛痘印乳液的制备2.5 Preparation of Scar Removing and Acne Printing Emulsion
a)称取海藻酸钠0.08g,加水7ml,静置过夜后搅拌均匀,即得海藻酸钠凝胶液a;a) Weigh 0.08 g of sodium alginate, add 7 ml of water, and stir evenly after standing overnight to obtain sodium alginate gel liquid a;
b)称取阳离子瓜尔胶0.16g,加水5.8ml,静置过夜后搅拌均匀,即得阳离子瓜耳胶凝胶液b;b) Weigh 0.16 g of cationic guar gum, add 5.8 ml of water, and stir evenly after standing overnight to obtain cationic guar gum gel liquid b;
c)称取D-泛酰醇1g,加水2ml,搅拌溶解,得D-泛酰醇溶液c;c) Weigh 1 g of D-panthenol, add 2 ml of water, stir and dissolve to obtain D-panthenol solution c;
d)称取芦荟油0.8g,杏仁油1.2g,金盏花油1.2g,沙棘油0.8g,马油1.1g,鸸鹋油0.9g,ML乳化剂1.9g,橄榄乳化剂1.7g于小烧杯中,置水浴锅上,保持温度80℃,水浴加热,溶化,混匀作为油相;d) Weigh 0.8g of aloe vera oil, 1.2g of almond oil, 1.2g of calendula oil, 0.8g of seabuckthorn oil, 1.1g of horse oil, 0.9g of emu oil, 1.9g of ML emulsifier, and 1.7g of olive emulsifier In a beaker, place it on a water bath, keep the temperature at 80°C, heat it in a water bath, melt it, and mix it as an oil phase;
e)量取蒸馏水25ml于烧杯中,置水浴锅上,保持温度80℃,水浴加热,作为水相;e) Measure 25ml of distilled water in a beaker, place it on a water bath, keep the temperature at 80°C, and heat it in a water bath to serve as the water phase;
f)待烧杯中油相完全熔融,将同温的烧杯中的水相缓缓倒入油相中,边加边向同一方向搅拌15min,至呈均匀淡黄色乳状固体,从水浴锅中拿出并冷却至室温;f) After the oil phase in the beaker is completely melted, slowly pour the water phase in the beaker at the same temperature into the oil phase, and stir in the same direction for 15 minutes while adding, until it becomes a uniform light yellow milky solid, take it out from the water bath and mix Cool to room temperature;
g)待基质放冷后加入甘油2g、1%透明质酸钠0.5g、D-泛酰醇溶液c、丹参提取液1g、白僵蚕提取液1.2g、桃仁提取液1.4g、积雪草提取液1.5g,依次搅拌均匀后加入下一项,最后加入硅油1.2g,搅拌均匀;g) After cooling the matrix, add 2g of glycerin, 0.5g of 1% sodium hyaluronate, D-panthenol solution c, 1g of salvia miltiorrhiza extract, 1.2g of white silkworm extract, 1.4g of peach kernel extract, Centella asiatica Extract 1.5g, stir well in turn, then add the next item, finally add 1.2g of silicone oil, stir well;
h)所得的乳中加入已经溶胀完全的海藻酸钠凝胶液a和阳离子瓜耳胶液b,搅拌10min,混合均匀得乳液g;h) Add sodium alginate gel liquid a and cationic guar gum liquid b that have swelled completely to the obtained milk, stir for 10 min, and mix uniformly to obtain emulsion g;
i)向乳液g中加入复方抗菌剂2ml,水蜜桃香精1滴,搅拌均匀,即得。i) Add 2ml of compound antibacterial agent and 1 drop of peach essence to emulsion g, stir evenly to get ready.
实施例3Example 3
3.1丹参提取液的制备3.1 Preparation of Danshen extract
称取丹参40g,浸泡0.5h,加热至100℃,煎煮提取3次,第一次加12倍量的水,提取1h,第二次加10倍量的水,提取1h,第三次加8倍量水,提取0.5h,每次滤过,合并滤液,滤液的体积浓缩至120ml,过滤即得。Weigh 40g of Salvia miltiorrhiza, soak for 0.5h, heat to 100°C, decoct and extract 3 times, add 12 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time, extract for 1 hour, and add for the third time 8 times the amount of water, extract for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 120ml, and filter to obtain.
3.2白僵蚕提取液的制备3.2 Preparation of silkworm extract
称取白僵蚕40g,加热至100℃,煎煮提取3次,第一次加10倍量的水,提取1h,第二次加9倍量的水,提取1h,第三次加8倍量的水,提取0.5h,每次滤过,合并滤液,滤液体积浓缩至120ml,过滤即得。Weigh 40g of white silkworm, heat to 100°C, decoct and extract 3 times, add 10 times the amount of water for the first time, extract for 1 hour, add 9 times the amount of water for the second time, extract for 1 hour, and add 8 times for the third time amount of water, extract for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 120ml, and filter to obtain.
3.3桃仁提取液的制备3.3 Preparation of peach kernel extract
称取桃仁粗粉30g,加热至100℃,煎煮提取2次,第一次加10倍量的水,提取1h,第二次加8倍量的水,提取1h,两次过滤,合并滤液,滤液体积浓缩至90ml,过滤即得。Weigh 30g of peach kernel powder, heat to 100°C, decoct and extract twice, add 10 times the amount of water for the first time, extract for 1 hour, add 8 times the amount of water for the second time, extract for 1 hour, filter twice, and combine the filtrates , the volume of the filtrate was concentrated to 90ml, and filtered.
3.4积雪草提取液的制备3.4 Preparation of Centella Asiatica Extract
称取积雪草50g,剪碎,浸泡0.2h,加热至100℃,煎煮提取3次,第一次加12倍量的水,提取1h,第二次加10倍量的水,提取1h,第三次加8倍的水提取0.5h,每次过滤,合并滤液,滤液体积浓缩至200ml,过滤即得。Weigh 50g Centella asiatica, cut into pieces, soak for 0.2h, heat to 100°C, decoct and extract 3 times, add 12 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time, extract for 1 hour , add 8 times of water for the third extraction for 0.5h, filter each time, combine the filtrate, concentrate the volume of the filtrate to 200ml, and filter to obtain.
3.5祛疤祛痘印乳液的制备3.5 Preparation of Scar and Acne Removing Emulsion
a)称取海藻酸钠0.09g,加水9ml,静置过夜后搅拌均匀即得海藻酸钠凝胶液a;a) Weigh 0.09g of sodium alginate, add 9ml of water, let it stand overnight and stir evenly to obtain sodium alginate gel liquid a;
b)称取阳离子瓜尔胶0.18g,加水7ml,静置过夜后搅拌均匀即得海藻酸钠凝胶液b;b) Weigh 0.18 g of cationic guar gum, add 7 ml of water, and stir evenly after standing overnight to obtain sodium alginate gel liquid b;
c)称取D-泛酰醇1.5g,加水3ml,搅拌溶解得D-泛酰醇溶液c;c) Weigh 1.5 g of D-panthenol, add 3 ml of water, stir and dissolve to obtain D-panthenol solution c;
d)称取芦荟油2g,杏仁油1.2g,金盏花油2g,沙棘油2g,马油2g,鸸鹋油2g,ML乳化剂2g,橄榄乳化剂2g于小烧杯中,置水浴锅上,保持温度80℃,水浴加热,溶化,混匀;d) Weigh 2g of aloe vera oil, 1.2g of almond oil, 2g of calendula oil, 2g of seabuckthorn oil, 2g of horse oil, 2g of emu oil, 2g of ML emulsifier, and 2g of olive emulsifier in a small beaker, and place on a water bath , keep the temperature at 80°C, heat in a water bath, dissolve, and mix well;
e)量取蒸馏水24ml于烧杯中,置水浴锅上,保持温度80℃,水浴加热;e) Measure 24ml of distilled water in a beaker, place it on a water bath, keep the temperature at 80°C, and heat it in a water bath;
f)待烧杯中油相完全熔融,将同温的烧杯中的水相缓缓倒入油相中,边加边向同一方向搅拌15min,至呈均匀淡黄色乳状固体,从水浴锅中拿出并冷却至室温;f) After the oil phase in the beaker is completely melted, slowly pour the water phase in the beaker at the same temperature into the oil phase, and stir in the same direction for 15 minutes while adding, until it becomes a uniform light yellow milky solid, take it out from the water bath and mix Cool to room temperature;
g)待基质放冷后加入甘油2g、1%透明质酸钠1.5g、D-泛酰醇溶液c、丹参提取液1.5g、白僵蚕提取液1.5g、桃仁提取液1.5g、积雪草提取液1.5g,依次搅拌均匀后加入下一项,最后加入硅油1.2g,搅拌均匀;g) After cooling the matrix, add 2g of glycerin, 1.5g of 1% sodium hyaluronate, D-panthenol solution c, 1.5g of Salvia miltiorrhiza extract, 1.5g of white silkworm extract, 1.5g of peach kernel extract, snow asiatica Grass extract 1.5g, stir evenly in turn, then add the next item, finally add 1.2g of silicone oil, stir evenly;
h)所得的乳加入已经溶胀完全的海藻酸钠凝胶液a和阳离子瓜耳胶液b,搅拌10min,混合均匀得乳液g;h) Add the obtained milk to the fully swollen sodium alginate gel solution a and cationic guar gum solution b, stir for 10 minutes, and mix evenly to obtain emulsion g;
i)向乳液g中加入万能复方抗菌剂3ml,柠檬香精6滴,搅拌均匀即得。i) Add 3ml of universal compound antibacterial agent and 6 drops of lemon essence to the emulsion g, and stir evenly.
实施例4Example 4
实施例1、2、3的理化指标如下:The physicochemical index of embodiment 1,2,3 is as follows:
4.1性状4.1 Traits
本乳液呈淡乳黄色,稠度适宜,轻盈水润,细腻均匀,涂展性良好、气味芬芳。The emulsion is light milky yellow, with suitable consistency, light and moist, fine and uniform, good spreadability and fragrant smell.
4.2pH值检查4.2 pH check
取本品,用pH计测定,测得pH值为5-6之间。Take this product and measure it with a pH meter, and the measured pH value is between 5-6.
4.3冷热试验4.3 Hot and cold test
将乳液封装于透明化妆品瓶中,于4℃的冰箱冷藏一个月观察无分层现象。于55℃的恒温箱内24h,乳液无分层乳化变味等现象。The emulsion was packaged in a transparent cosmetic bottle and refrigerated in a refrigerator at 4°C for one month to observe no delamination. In a constant temperature box at 55°C for 24 hours, the emulsion has no phenomenon of stratification, emulsification and odor change.
4.4离心试验4.4 Centrifugal test
将乳液封装于具塞试管中3000r/min离心20min,无分层现象。The emulsion was packaged in a stoppered test tube and centrifuged at 3000r/min for 20min, without stratification.
4.5室温放置实验4.5 Placement experiment at room temperature
将实施例1、2、3所制的乳液置于化妆品瓶中,室温静置考察6个月,无分层现象,用后感觉无变化,气味无变化。The emulsions prepared in Examples 1, 2, and 3 were placed in a cosmetic bottle, and left to stand at room temperature for 6 months to investigate. There was no delamination, no change in sensation after use, and no change in smell.
4.6刺激性试验、过敏性实验4.6 Irritation test, allergy test
小白鼠背部剪去毛,分别涂抹按实施例1、2、3制备的乳液于剪去毛的部位,和没涂部位进行比较,结果没有刺激性和过敏反应。The hair on the back of the mouse was cut off, and the emulsions prepared in Examples 1, 2, and 3 were applied to the cut-off parts respectively, and compared with the uncoated parts, the results showed no irritation and allergic reaction.
取实施例1、2、3所得的乳液1克涂于志愿者(15-65岁,120人)手面上,过30分钟后观察,均没出现发红,发疹,起泡现象。Get 1 gram of the emulsion of embodiment 1,2,3 gained and apply on the hands of volunteers (15-65 years old, 120 people), observe after 30 minutes, all do not appear rubescent, eruption, foaming phenomenon.
实施例5:Example 5:
祛疤祛痘印效果实验Experiment on the effect of removing scars and acne marks
通过试用实验来评价实施例1、2、3的祛疤祛痘印效果。利用实施例1、2、3生产出来的乳液与市售祛疤祛痘印药膏进行对比实验。选取18-40岁男女各120名,把他们按男女比例等分成4个组。每天早晚各两次用乳液搽疤痕处(亦可涂于无疤痕处皮肤),实施例1组用按实施例1制备的乳液,实施例2组用按实施例2制备的乳液,实施例3组用按实施例3制备的乳液,对照组涂抹市售祛疤祛痘印药膏,连续使用两个月。用肉眼观察疤痕处的淡化情况来评价祛疤祛痘印效果。此结果见表2:Evaluate the effect of removing scars and acne marks of Examples 1, 2, and 3 through trial experiments. The emulsions produced in Examples 1, 2, and 3 were compared with the commercially available ointment for removing scars and acne. Select 120 men and women aged 18-40, and divide them into 4 groups according to the ratio of men and women. Every morning and evening, the scars are painted with emulsion twice (also can be applied to the skin without scars). The emulsion prepared in Example 1 is used in Example 1 group, the emulsion prepared in Example 2 is used in Example 2, and the emulsion prepared in Example 3 is used in Example 3. The group used the emulsion prepared according to Example 3, and the control group applied the commercially available ointment for removing scars and acne, and used it continuously for two months. Use the naked eye to observe the lightening of the scars to evaluate the effect of removing scars and acne marks. The results are shown in Table 2:
表2祛疤祛痘印实验结果Table 2 Experimental results of removing scars and acne marks
实施例6:Embodiment 6:
该乳液综合效果考察Investigation of the comprehensive effect of the emulsion
以下利用试用感觉来评价实施例1、2、3制造出的乳液的功效。采用民意调查评分法,选取80名18-40岁年龄段的男、女性各半作为试用对象,按男女比例等分成两组,分别用实施例1、2、3制备的乳液搽疤痕、痘印处。每天使用两次,使用时间两个月。各项使用效果总分为5分:五分为最高分,表示很好,非常满意;4分为较好;3分为可以接受;3分以下为不好,不能接受。以下为各项平均得分。结果见3表:The efficacy of the emulsions produced in Examples 1, 2, and 3 will be evaluated by using the trial experience below. Using the public opinion survey scoring method, select 80 men and women in the 18-40 age group as trial subjects, divide them into two groups according to the ratio of men and women, and use the lotion prepared in Examples 1, 2, and 3 to paint scars and acne marks respectively. place. Use twice a day for two months. The total score of each use effect is 5 points: 5 points are the highest score, which means very good and very satisfied; 4 points are good; 3 points are acceptable; below 3 points are bad and unacceptable. Below are the average scores for each category. The results are shown in Table 3:
表3综合效果考察Table 3 Comprehensive effect investigation
综上所述,本发明所制的该乳液有良好的淡化疤痕痘印、滋润、保湿的功效,用后皮肤有弹性,白皙,疤痕、痘印渐渐淡化甚至消失。To sum up, the emulsion prepared by the present invention has good effects of lightening scars and acne marks, moisturizing and moisturizing. After use, the skin is elastic and fair, and the scars and acne marks gradually fade or even disappear.
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CN104027281A (en) * | 2014-07-03 | 2014-09-10 | 广州丹奇日用化工厂有限公司 | Acne removing cosmetic composition and preparation method thereof |
CN104257540A (en) * | 2014-09-09 | 2015-01-07 | 青岛市高科专利技术转移平台有限公司 | Ecological moisturizing lotion |
CN104740321A (en) * | 2015-03-31 | 2015-07-01 | 成都中医药大学附属医院 | Traditional Chinese medicine composition for removing chloasma and preparation method thereof |
CN105343450A (en) * | 2015-10-28 | 2016-02-24 | 皖南医学院 | Emulsion for treating keratosis pilaris and preparation method of emulsion |
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