CN103969433A - Sample detection apparatus - Google Patents
Sample detection apparatus Download PDFInfo
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- CN103969433A CN103969433A CN201310039628.8A CN201310039628A CN103969433A CN 103969433 A CN103969433 A CN 103969433A CN 201310039628 A CN201310039628 A CN 201310039628A CN 103969433 A CN103969433 A CN 103969433A
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- 238000001514 detection method Methods 0.000 title abstract description 25
- 238000012360 testing method Methods 0.000 claims abstract description 223
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- 239000012530 fluid Substances 0.000 abstract description 12
- 238000009792 diffusion process Methods 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 161
- 210000003296 saliva Anatomy 0.000 description 20
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- 238000010521 absorption reaction Methods 0.000 description 5
- 239000003365 glass fiber Substances 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000012491 analyte Substances 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
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- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 2
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The present invention relates to a sample detection apparatus, which comprises a collection chamber for collecting samples and a test element for detecting the sample, wherein the collection chamber and the test element form a fluid communication, and the apparatus further comprises a draining element for making the sample in the collection chamber do not directly flow into the test element. With the sample detection apparatus, the condition that the corresponding detection can not be performed timely due to direct diffusion of the sample out from the test element so as to cause the not significant or invalid detection result can be prevented, and the requirement of the collection amount on the sample is broadened, such that the application range of the detection apparatus is wide.
Description
Technical field
The present invention relates to a kind of sample testing apparatus, particularly there is the sample testing apparatus chamber of collection and measuring ability simultaneously.
Background technology
In our society, illicit drug use has become a social concern of generally acknowledging and increasingly worsening.2003, U.S. Department of Health and Human Service investigation found approximately have 1,950 ten thousand Americans or the crowd of 8.2% age more than 12 years old sucking illegal medicine." use recently illegal medicine " and refer at U.S. Department of Health and Human Service and investigate in previous month and used a kind of illegal medicine.Hemp is found to be the most frequently used illegal medicine, accounts for 6.2% (1,460 ten thousand).Estimate that 2,300,000 people (1.0%) are using cocaine now, 604,000 people have used crack, have 1,000,000 people to use psychedelic, and estimate that 119,000 people are using heroin.
In order to hit drug abuse and this social concern of monitoring, drug test is for example employed in every profession and trade, education, physical culture, law enforcement etc. have become standard detection program.In order to promote this effort, drug test industry forms, and this industry provides various drug test product.US Patent No. 2004/0184954 and US2004/0237674 disclose some devices of collecting saliva and detecting.
In these patents, disclose and utilized a pick-up unit to collect saliva sample and detect the content of various illegal drugs in this saliva sample.These devices are made up of the test chamber of collecting the collecting chamber of sample and comprise testing element conventionally, collect detected person's saliva sample by collecting excellent spongy top, then utilize collecting chamber and external force cooperation extruding spongy top that saliva sample is collected in sample chamber, then detect by being fed directly in sample chamber on the testing element of test chamber.These pick-up units can effectively detect detected person and whether have the situation of abusing forbidden drug.But, in actual detection, can there is following problem:
In the time that the sample size of collecting is excessive, can cause sample to flow into amount of liquid on testing element excessive, directly cover whole testing element, thereby make the antigen or the antibody that have little time on testing element carry out relevant immune response, particularly on the testing result viewing area of testing element, also cannot carry out corresponding immune response, finally cause detecting, can not get testing result.
Analyze its reason, find can directly touch due to the sample in collecting chamber the sample receiving area of testing element, larger once sample size, can exist a large amount of samples directly to flow through (covering) follow-up reagent reacting district, sufficient immune response cannot be carried out, thereby detection cannot be realized.
Summary of the invention
[0003] to address this problem, need to make sample can be not disposable a large amount of flowing on testing element, best mode is that sample does not directly touch testing element, but flow on testing element by the mode of drainage.Like this, just can not exist sample too greatly directly to cover the situation that testing element causes the reaction on testing element not complete because of flow.The present invention has just been to provide a kind of new sample testing apparatus that can realize this function, this device comprises the collecting chamber of collecting sample, detect the testing element of sample, collecting chamber is communicated with testing element fluid-phase, wherein, this device also comprises that one makes the sample in collecting chamber not be fed directly to the drainage element on testing element.More preferred, in collecting chamber, sample flow on testing element by this drainage element.
On pick-up unit of the present invention, having had the sample making in collection well is not fed directly to after the drainage element on testing element, can make the not direct engaged test element of sample, but by one can draining fluids element sample is transitioned on testing element in the mode of drainage, thereby can stop sample and cover whole testing element, particularly the situation in test result region.If sample directly covers testing element, during such as test strip, first, can cause the mark substance in test strips to be diluted, thereby the concentration of mark substance is on the low side, and it is inhomogeneous that mark substance is discharged in the process of reacting with analyte in sample, finally causes the display line of testing result on the weak side, cannot observe, or show that lines are inhomogeneous or break; Secondly, when sample directly covers test strips, can cause the antigen of surveyed area or antibody have little time with in sample and mark substance react completely, finally also can cause testing result display line on the weak side, affect testing result.And utilize after pick-up unit of the present invention, sample is in the mode of drainage, after directly the mode of contact does not flow on testing element, first sample is added on this drainage element, and after flow expansion by drainage element, flow on testing element in the mode of dialysis, first pass through the sample receiving area of testing element, make sample can be distributed to more uniformly each region of testing element sample region of acceptance, then laterally flow into uniformly marked region, carry out immune response with the amalyzing substances that is fixed on marked region, and then flow into uniformly control area and surveyed area below, carrying out further reaction and result shows.Therefore, the pick-up unit of this new structure can effectively prevent from adding because sample is direct or sample too much has little time to make testing element directly to cover by the mode transfer samples of dialysis the series of problems that whole testing element causes, and, because of the difference of person under inspection's individual difference XOR sampling mode, cause sampling amount size to be not quite similar, carry out the pick-up unit of pattern detection by this drainage way and can also widen the scope that sample size is added, particularly in the situation that sample size is bigger than normal, thereby also widen the pattern detection scope of sample testing apparatus, this device can be applied more extensive.
The material of drainage element need to meet medical standard and have the function that absorbs and transmit sample, particularly saliva sample, such as, sponge, filter paper, glass fibre and polyester film etc.
One preferred embodiment in, the structure that between collecting chamber and testing element, fluid-phase is communicated with is to make the sample in collecting chamber not be fed directly to the structure on testing element.In a concrete embodiment, the structure that the sample in collecting chamber is not fed directly on testing element is the through hole that is positioned at collecting chamber bottom; And the sample receiving area of testing element is not under through hole, but on position away from through hole.。
This special structure between collecting chamber and testing element is same sample can directly not contacted or shower to testing element, particularly on the sample receiving area of testing element, thereby avoid having little time to absorb a large amount of liquid samples that disposable a large amount of sample causes and directly covering because of sample receiving area the sample receiving area of testing element, and further cover follow-up surveyed area and territory, results display area, sample occurs to be had little time to mark substance combination or has little time to carry out relevant immune response with amalyzing substances, finally avoid testing result show not obvious or detect unsuccessfully.The liquid flowing out by collecting chamber through hole is not because testing element is or not lead to the hole site place, can directly not touch testing element, the particularly sample receiving area of testing element, but flow on a carrier, such as, the cavity of bearing test element, or a drainage element etc., absorb sample by sample receiving area by the mode of dialysis again, thereby flow into again other regions of testing element.So just do not exist sample directly to cover the situation of testing element, meanwhile, in the time that sample addition increases, can ensure that this pick-up unit completes detection smoothly yet, widened to a certain extent the sensing range of the sample size of this pick-up unit.
In a preferred mode, the sample flowing down from through hole can directly not contact sample receiving area or not flow directly to sample receiving area, but flows on sample receiving area by drainage element.In another concrete embodiment, the top of the sample receiving area of through hole network topology testing element.In preferred mode, the top of testing element is 0-2mm apart from the spacing of through hole.In a concrete preferred embodiment, the top of testing element is apart from the spacing 0.5mm of through hole.
In a preferred embodiment, one end of drainage element is connected with the sample receiving area of testing element, and the other end is connected with the through hole of collecting chamber.Sample in collecting chamber flows out by through hole, flow into the one end that is attached thereto the drainage element connecing, by absorption and the diffusion of drainage element, sample is full of whole drainage element, then flow on the sample region of acceptance of the testing element that is connected to the drainage element other end.
In other embodiments, this pick-up unit also comprises the test chamber for holding testing element, and this test chamber is connected with collecting chamber by the through hole of collecting chamber bottom.
In another concrete embodiment, drainage element is positioned at test chamber.
More specifically, in embodiment, one end of drainage element is connected with the sample receiving area of testing element, and the other end of drainage element is positioned at through hole below and is connected with through hole.
In some preferred implementations, the material of this drainage element is identical with the material of the sample receiving area of testing element, and like this, the sample distribution that can make to flow into by drainage element sample region of acceptance is more even.In a preferred embodiment, this drainage element is glass fibre material.
Some preferred embodiment in, the testing element that is positioned at test chamber is at least one, drainage element is connected with the sample receiving area of described testing element simultaneously.When testing element is when more than 2 or 2, the sample receiving area of each testing element is connected with drainage element.Like this, because sample distributes through the Uniform Flow of drainage element, can ensure to flow to sample size on each testing element even, thereby ensure that the detection of each testing element can promptly and accurately and effectively complete.
In the present invention, the shape of through holes of collecting chamber bottom and size need to meet can make the liquid sample in chamber directly not touch the condition of testing element, and finally smoothly sample is sent on testing element.In some concrete embodiments, through hole is semicircle.In preferred mode, the radius of this semi-circular through hole is 2-6mm.In a specific embodiment, the radius of this semi-circular through hole is 4mm.
beneficial effect
by sample testing apparatus of the present invention, can prevent that sample from directly covering testing element and having little time to carry out corresponding detection reaction and cause the situation that testing result is not obvious or invalid; And this pick-up unit requires to relax to the collection capacity of sample, makes the range of application of pick-up unit more extensive.
Brief description of the drawings
Fig. 1 is the explosive decomposition figure of a sample testing apparatus of the present invention
Fig. 2 is a part (collecting chamber and the test chamber upper plate) structural representation of the sample testing apparatus of Fig. 1
Fig. 3 is the sectional view of the sample testing apparatus of Fig. 1
Fig. 4 is the part enlarged drawing of the sectional view of this pick-up unit of Fig. 3, represents position relationship between test strips and collecting chamber through hole
Fig. 5 is the structural representation of a test strips in pick-up unit
Description of reference numerals:
Sample testing apparatus 500, collection well 100, collecting chamber sidewall 101, collecting chamber bottom through-hole 102, collecting chamber base seal part 103, test chamber 200, test chamber upper plate 201, test chamber lower plate 202, test chamber internal protrusion 203, 205, test chamber window 204, test strips draw-in groove 206, test strips location-plate 207, testing element/test strips 300, the top 310 of testing element/test strips, sample region of acceptance 311, marked region 312, territory, results display area 313, suction zone 314, sample pad 301, label pad 302, NC film 303, thieving paper 304, test strips base plate 305, test result lines T line 331, detect control line C line 332, drainage element/drainage pad 400, drainage element/drainage pad one end 401, drainage element/drainage pad other end 402
Embodiment
Below the structure the present invention relates to or these technical terms using are described further.
sample
" sample " that the present invention refers to refers to needs and chemically examines any material that whether has and (or) analyze analyte concentration, maybe need to determine whether one or more samples exist and (or) the material of the analyte of quantity, maybe need to carry out the material of qualitative evaluation.Sample can be fluid sample, for example fluid sample.Fluid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Fluid sample can be also water sample, such as seawater, river, river etc., or from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making fluid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and in fluid, make sample.Sample can comprise potpourri or any relevant potpourri of fluid, solid and gas, such as the cell suspending liquid in dilution or solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Fluid sample can be produced from solid, semisolid or the high-viscosity material such as such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature nonfluid sample.For example, the solution that these solids or semi-solid samples can be suitable with dilution one class mixes.Sample can be macerated, freezing and thaw, or other extracting method form fluid samples.Remaining particulate material can use the method that filtration or precipitation etc. are traditional to remove.Be suitable for the sample that the present invention detects and include but not limited to body fluid, the sample separating from biological tissue or body fluid.For example, sample can be saliva, blood, serum, blood plasma, urine, excreta, spinal fluid, vaginal secretion, mucus and tissue.
testing element
" testing element " is any element of carrying out test.In one embodiment, testing element is test strips.This test strips can comprise the material pair with specific binding for immunoassay thereon.Test strips can be a kind of test chemical bar that passes through change color or other signal intensity judged results after detection completes.Testing element or test strips are not limited to one, can be that two or more testing elements are arranged in pick-up unit simultaneously, respectively different component in test sample book.Conventionally, test strips 300 is by sample pad 301, label pad 302, and NC film 303 and thieving paper 304 stick in turn on kilocalorie base plate 305 and form, as shown in Figure 5; And test strips is divided into sample region of acceptance 311, marked region 312, territory, results display area 313 and suction zone 314, as shown in Figure 1.
sample collection rod
In one embodiment, sample collection rod has an absorption carrier and is affectedly bashful portion.Other sponge of medical grade or plastic foam material that absorption carrier is commonly used by this area are conventionally made.But many other materials also can be made into absorption carrier, for example cotton or paper, or other any materials with water absorbing properties.Absorb carrier and there is certain elasticity, in the time being subject to external force pressure, can compression stroke and diminish, and when external force reduces or disappear, absorption carrier can progressively restore to the original state.Sample collection rod can be in advance soaking containing in can stimulating the salivary solution of tester.Thereby make more easily to collect saliva in the time that collection rod is put into tester's mouth.Be affectedly bashful normally rigidity of portion, be conducive to the operation to absorbing carrier.The material that the portion of being affectedly bashful can be commonly used by this area is made, for example plastics, timber, metal or cardboard.
In the following detailed description, the subsidiary reference word of legend is a part here, and it illustrates to illustrate the mode that the present invention can actable specific concrete scheme.We do not get rid of the present invention and can also carry out other concrete scheme and without prejudice to usable range of the present invention in the situation that, change structure of the present invention.
As depicted in figs. 1 and 2, a concrete sample testing apparatus 500 of the present invention comprises collection well 100 and test strips 300, and collecting chamber 100 is realized fluid-phase with test strips 300 by the through hole 102 of collecting chamber bottom and is communicated with.Wherein, collecting chamber 100 1 end openings, by sidewall 101 and bottom 102,103 enclose and form, and receive sample collection rod by one end of opening, and the extruding that coordinates with collecting chamber by external force, make to be positioned at and collect rod above, the liquid sample of collecting excellent collecting part enters in collecting chamber 100.This pick-up unit 500 also comprises drainage element 400, this drainage element 400 is connected between the through hole 102 and test strips 300 of collecting chamber, between the two, play bridge beam action, the sample in collection well 100 is sent in test strips 300 by drainage element 400.As shown in Figure 3, one end 401 of drainage element is positioned at the below of through hole 102 to concrete connected mode, and the other end 402 is connected to the top of the sample receiving area 301 of test strips 300.Conventionally, the material of drainage element 400 is identical with the sample receiving pad of test strips 301 materials, and in specific embodiment, this drainage element 400 is glass fibre material.More specifically in embodiment, this drainage element is the drainage pad 400 that has glass fibre material to make, and the thickness of this drainage pad 400 can be identical with the thickness of sample receiving pad 301, in some specific embodiments, the thickness of drainage pad 400 is between 0.1-0.8mm.The size of drainage pad pad 400 can be determined in the position of test chamber 200 according to the size of test chamber 200 and drainage pad 400.In some embodiment, the length of drainage pad 400 is between 5-15mm, and width is between 4-10mm.When the sample in collecting chamber 100 arrives 401 places, one end on drainage pad by through hole 102 after, adsorbed by one end 401 of drainage pad rapidly and spread to whole drainage pad by the mode of dialysis, thereby arrive the other end 402 of drainage pad, with 311 junctions, sample region of acceptance of test strips, further dialysis is to the sample receiving area 311 of test strips, to realize the measuring ability of test strips 300.
As shown in Figures 3 and 4, the top 310 of the through hole 201 contiguous test strips of this collecting chamber, in some specific embodiments, the distance H on the top 310 of the Edge Distance test strips of through hole 102 is between 0-2mm.Preferably, this distance H is 0.5mm.Through hole has after distance apart from the top of test strips, after sample is discharged by through hole, can directly not arrive in test strips, but be arranged on test chamber or drainage pad, because the sample region of acceptance 311 of test strips is positioned at the top 310 of test strips, liquid sample can be absorbed by the sample reception area 311 of test strips by the mode of dialysis and capillary action.Thereby the phenomenon that directly covers test strips (being FLOODING phenomenon) of effectively having prevented sample directly to arrive test strips and to cause.
In another specific embodiment, this pick-up unit also comprises a test chamber 200, and this test chamber 200 is connected and is communicated with collecting chamber 100.In some embodiment, collecting chamber 100 is that one-shot forming forms with the upper plate of test chamber 200, as shown in Figure 2.Test strips 300 is positioned at test chamber 200, more specifically, test chamber 200 is made up of upper plate 201 and lower plate 202, test strips 300 is positioned at the upper of check-out console, between lower plate 201,202, and collecting chamber 100 is connected to one end of test chamber upper plate 201, collecting chamber 100 has through hole 102 with the junction of test chamber upper plate 201, and collecting chamber 100 is connected by through hole 102 with test chamber 200.These through hole 102 position correspondences are not in test strips 300, but one end of contiguous test strips, i.e. sample receiving area end 301, as shown in Figure 3.As shown in Figure 1, in the lower plate 202 of test chamber, have and lay and draw-in groove 206 and the location-plate 207 of fixing test strips 300.One end of the sample receiving area 311 of test strips is positioned on location-plate 207, and the other end (suction zone 314) is positioned at draw-in groove 206.Projection 203 is for blocking 310 places, top of firm test strips, further fixing test strips 300, this projection 203 is also positioned at the sample receiving area 311 of test strips for one end 402 of supporting drainage pad 400. drainage pads simultaneously, and the other end 401 is positioned at the below of through hole 102, shown in Fig. 3.On test chamber upper plate 201, also there is the window corresponding with the territory, results display area 313 of test strips 204, window can be the space of directly vacating, or, on space, cover transparent material, in a word, can make the territory, results display area of the test strips that is positioned at test chamber reveal.When this pick-up unit 500 carries out after pattern detection, observe testing result by the window 204 of this test chamber, i.e. T line 331 and C line 332.
The collecting chamber 100 of this pick-up unit should use the material that meets medical standard to make with the material of test chamber 200, conventionally can use plastics, PP, and PVC material is made.
As shown in Figure 2, the through hole 102 that collecting chamber 100 is connected with test chamber 200 and drainage pad is positioned at the bottom of collecting chamber, in a specific embodiment, because utilizing columniform spongy top conventionally, sample collection rod collects sample, so collecting chamber 100 inside are cylindrical shape, thereby the bottom of collecting chamber is circular.More specifically, the opening of collecting chamber bottom is that whole bottom is through hole, is connected with test chamber 200.In a preferred embodiment, flow into quantity and the speed of drainage pad 400 in order to control sample, the through hole 102 of this collecting chamber bottom is a semicircle, and this half radius of a circle is conventionally between 2-6mm.Collecting chamber bottom not opening portion 103 is identical with through hole 102 sizes.As shown in Figure 3, the sample receiving area 311 of test strips is positioned at the not below of opening 103, collecting chamber bottom, is fixed by the projection 205 at 103 places, collecting chamber bottom.And the top 310 of test strips is positioned at protruding 203 places, as shown in Figure 4, the top 310 of test strips 300 is not corresponding with opening 102 positions of collecting chamber, and has certain distance H, and the liquid flowing out by through hole 102 in collecting chamber 100 can directly not touch test strips 300.
As shown in Figure 5, test strips 300 has sample receiving pad 301, label pad 302 and NC film 303 and thieving paper 304 form, wherein, in the time that sample flow is crossed test strips 300, flow through successively sample receiving pad 301, the T line on label pad 302 and NC film 303 and C line region and thieving paper 304, thus complete relevant detection.
In certain embodiments, in test chamber 200, there are multiple test strips 300, like this, can realize the function of the utilization multiple analyte of pattern detection once.In a specific embodiment, in the test chamber 200 of this pick-up unit 500, comprise two test strips 300, as shown in Fig. 1 and Fig. 3 sectional view, drainage pad 400 is connected with two test strips 300 simultaneously, like this, be more conducive to sample to be distributed to uniformly in two test strips, thereby ensure that two test strips obtain enough samples to complete corresponding detection.
Embodiment
For how clearer elaboration the present invention realizes and beneficial effect of the present invention, now describe with limited experiment, limited giving an example only done in these explanations under the marrow of claim of the present invention, do not form limiting to the claimed invention.
embodiment: the sample testing apparatus of a specific embodiment of the present invention and the sample testing apparatus of the detection identical component of buying are on the market carried out to pattern detection comparison (morphine in detection person under inspection's saliva, meth and ketamine composition)
material:
1. our company produces the sample testing apparatus of a specific embodiment of the present invention: as shown in Figure 1, this pick-up unit comprises collecting chamber, and the test chamber being connected with collecting chamber and two test strips that are positioned at test chamber; Wherein, drainage pad is positioned at test chamber, and one end is connected with the through hole of collecting chamber bottom, and the other end is connected with the sample region of acceptance of two test strips, and drainage pad is glass fibre material, is of a size of: the wide X of the 9mm X 7mm long X of X 0.5mm(is high); The through hole of collecting chamber is that radius is the semicircle of 4mm, and through hole is 0.2mm apart from the spacing H on the top of test strips;
2. the bright prompt brand (lot number: sample testing apparatus (this device can not detect ketamine composition) 20120701): this pick-up unit does not have drainage element that in the purchase of market, Sheng Langjie company produces, and collecting chamber bottom through-hole is positioned on the sample region of acceptance of test strips of test chamber;
3. the same person under inspection's who obtains at one time saliva sample;
4. the homemade colorimetric card of our company: the ratio color range of colorimetric card, between 0-10, wherein, can demonstrate the scope of result line between 7-10,, when the line color of testing result drops in the scope of 7-10, shows that testing result is negative.In the time that lines are not within the scope of this, be the testing result positive or check that testing result shows incorrect;
step:
1. draw in each 2 of the pick-up unit that saliva sample 100ul adds respectively pick-up unit of the present invention and Lang Jie brand to liquid-transfering gun.
2. leave standstill 5 minutes, in this course, observe the mobility status of saliva sample on each pick-up unit.
3. utilize T line and C line in the window of colorimetric card interpretation pick-up unit.
4. draw in each 2 of the pick-up unit that identical saliva sample 150ul adds respectively pick-up unit of the present invention and Lang Jie brand to liquid-transfering gun.
5. repeating step 2 and step 3.
6. draw in each 2 of the pick-up unit that identical saliva sample 200ul adds respectively pick-up unit of the present invention and Lang Jie brand to liquid-transfering gun.
7. repeating step 2 and step 3.
8. draw in each 2 of the pick-up unit that identical saliva sample 300ul adds respectively pick-up unit of the present invention and Lang Jie brand to liquid-transfering gun.
9. repeating step 2 and step 3.
10. draw respectively identical saliva sample 400ul with liquid-transfering gun, 500ul and 600ul add to respectively in each 2 of pick-up unit of the present invention.
11. repeating step 2 and steps 3.
testing result:
Table one: product of the present invention and Lang Jie product 100ul and 150ul pattern detection data
Table two: product of the present invention and Lang Jie product 200ul and 300ul pattern detection data
Table three: product 400ul of the present invention, 500ul and 600ul pattern detection data
Illustrate:
1. FLOODING*: saliva sample directly covers pattern detection region, and overflow from watch window.
conclusion:
1. from result, product of the present invention adopts the sample size tolerance upper limit of the mode of drainage can reach 500ul, and adopt the bright prompt product of directly lower sample loading mode in the time that sample size reaches 300ul, just to occur FLOODING phenomenon (sample directly covers testing result region, can observe at window 204 places of test chamber).
2. from concrete T line strength (being colorimetric data scope), can see, the fluctuation of product of the present invention is less, and bright prompt product signal intensity weakens along with the overrun of application of sample amount obviously.
In practical operation, the accurate saliva amount that saliva sample acts on test strips is that dissimilar (unless with accurate liquid-transfering gun or other application of sample instrument application of sample, this situation is seldom appearance due to inconvenient operation.), application of sample amount tolerance scope is wider like this, means and occurs that abnormal risk is less.
Claims (14)
1. a sample testing apparatus, comprises the collecting chamber of collecting sample, detects the testing element of sample, and collecting chamber is communicated with testing element fluid-phase, and wherein, described device also comprises that one makes the sample in collecting chamber not be fed directly to the drainage element on testing element.
2. device as claimed in claim 1, is characterized in that, in collecting chamber, sample flow on testing element by this drainage element.
3. device as claimed in claim 2, is characterized in that, the structure that between collecting chamber and testing element, fluid-phase is communicated with is to make the sample in collecting chamber not be fed directly to the structure on testing element.
4. device as claimed in claim 3, is characterized in that, described in sample in collecting chamber is not fed directly on testing element structure be the through hole that is positioned at collecting chamber bottom; And the sample receiving area of described testing element is not under through hole, and on the position away from through hole.
5. device as claimed in claim 4, is characterized in that, the sample flowing down from through hole can directly not contact sample receiving area or not flow directly to sample receiving area, but flows on sample receiving area by drainage element.
6. device as claimed in claim 5, is characterized in that, the top of the sample receiving area of described through hole network topology testing element.
7. device as claimed in claim 6, is characterized in that, the spacing on the top of described through hole distance test element is 0-2mm.
8. device as claimed in claim 7, is characterized in that, one end of described drainage element is connected with the sample receiving area of testing element, and the other end is connected with the through hole of collecting chamber.
9. the device as described in one of claim 1-8, is characterized in that, this device also comprises the test chamber for holding testing element, and this test chamber is connected by the through hole of collecting chamber bottom with collecting chamber.
10. device as claimed in claim 9, is characterized in that, described drainage element is positioned at test chamber.
11. devices as claimed in claim 10, is characterized in that, one end of drainage element is connected with the sample receiving area of the testing element that is positioned at test chamber, and the other end of drainage element is positioned at collecting chamber through hole below and is connected with through hole.
12. devices as claimed in claim 11, is characterized in that, the material of drainage element is identical with testing element sample region of acceptance material.
13. devices as claimed in claim 12, is characterized in that, the testing element that is positioned at test chamber is at least one, and drainage element is connected with the sample receiving area of described testing element simultaneously.
14. devices as claimed in claim 13, is characterized in that, described through hole is semicircle; Semi-circular through hole radius is 2-6mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310039628.8A CN103969433A (en) | 2013-01-29 | 2013-01-29 | Sample detection apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310039628.8A CN103969433A (en) | 2013-01-29 | 2013-01-29 | Sample detection apparatus |
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| CN103969433A true CN103969433A (en) | 2014-08-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310039628.8A Pending CN103969433A (en) | 2013-01-29 | 2013-01-29 | Sample detection apparatus |
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| CN104535768A (en) * | 2014-11-25 | 2015-04-22 | 东莞市青麦田数码科技有限公司 | Urinary microalbumin detection apparatus |
| CN105136995A (en) * | 2015-09-30 | 2015-12-09 | 杭州康永生物技术有限公司 | Test paper testing structure |
| CN105136969A (en) * | 2015-09-30 | 2015-12-09 | 杭州康永生物技术有限公司 | Liquid testing device |
| CN105784443A (en) * | 2016-03-16 | 2016-07-20 | 杭州安旭科技有限公司 | Sample detection device, and sample collection and detection device and method |
| CN105866405A (en) * | 2016-04-06 | 2016-08-17 | 北海新升技术开发有限责任公司 | Rapid human immunodeficiency virus detection kit |
| CN105866400A (en) * | 2015-01-21 | 2016-08-17 | 艾博生物医药(杭州)有限公司 | Device for rapidly detecting and preserving samples and usage method thereof |
| CN106323949A (en) * | 2015-07-01 | 2017-01-11 | 宏达国际电子股份有限公司 | Detection device and pressurizing assembly thereof |
| WO2022194286A1 (en) * | 2021-03-19 | 2022-09-22 | 艾康生物技术(杭州)有限公司 | Test combination packet and test method |
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| CN105784443A (en) * | 2016-03-16 | 2016-07-20 | 杭州安旭科技有限公司 | Sample detection device, and sample collection and detection device and method |
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| CN105866405A (en) * | 2016-04-06 | 2016-08-17 | 北海新升技术开发有限责任公司 | Rapid human immunodeficiency virus detection kit |
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Application publication date: 20140806 |