CN206594173U - Device for detecting the analyte in fluid sample - Google Patents

Abstract

The utility model provides a device for detecting an analyte in a fluid sample. The device includes: a fluid sample collection element; a test element carrier; and a holding element, wherein the test element carrier is located in the holding element. In a preferred manner , the fluid sample collection element includes an absorbing element and a handle part, wherein the handle part includes a structure that cooperates with the holding element.

Description

Device for detecting an analyte in a fluid sample

technical field

The utility model relates to a device for detecting analytes in fluid samples.

Background technique

The following background art is used to help readers understand the utility model, and should not be regarded as prior art.

Illegal drug abuse is a well-recognized and worsening social problem in our society. In 2003, the U.S. Department of Health and Human Services found that about 19.5 million Americans, or 8.2% of the population over the age of 12, were taking illicit drugs. "Recent illicit drug use" refers to use of an illicit drug within the month preceding the investigation by the U.S. Department of Health and Human Services. Cannabis was found to be the most commonly used illicit drug, accounting for 6.2% (14.6 million). An estimated 2.3 million people (1.0%) are currently using cocaine, 604,000 have used crack, 1 million are using hallucinogens, and an estimated 119,000 are using heroin.

To combat drug abuse and monitor this social problem, drug testing has become a standard procedure in various industries such as employment, education, sports, law enforcement and more. To fuel this effort, a drug testing industry has formed. This industry offers a wide variety of drug testing products. The urine collection cup for sample analysis is a classic test product. These devices may be complicated, difficult, or dirty for the user, or may create problems with sample adulteration in order to conceal recent use of illicit drugs. In addition, urine samples cannot be collected in certain settings, such as on the side of the road or in public places.

Various sample collection and testing devices for clinical or home use are available and described in several literatures. For example, US Pat. No. 5,376,337 discloses a saliva sampling device in which a filter paper is used to collect saliva from a subject's mouth and transfer the saliva to an indicator reagent. US Patents US 5,576,009 and US 5,352,410 each disclose a syringe-type fluid sampling device. In these devices, after initial results are obtained, the collected fluid samples cannot be stored for later use in confirmatory testing.

Many other sample collection and testing devices are inefficient at extracting samples from the collection device. Many of these devices are very complex in their design and manufacture and require the use of relatively expensive materials. Therefore, better methods and devices are needed to collect and detect samples.

Utility model content

In order to solve the problems existing in the prior art, a device for collecting and detecting analytes in fluid samples is characterized in that the device includes:

A fluid sample collecting element, wherein the fluid sample collecting element includes an absorbing element and a handle for absorbing a liquid sample, and a connecting rod connecting the absorbing element and the handle;

The test element carrier, wherein the test element carrier includes a body for carrying the test element and a housing cavity for accommodating the absorbing element, wherein the body and the housing cavity are integrally formed by injection molding;

A cavity-containing retaining element, wherein the cavity of the retaining element is bounded by the opening, the rim of the opening, and the side walls;

Therein, the retaining element includes a structure allowing it to stand.

In a specific manner, the standing structure includes a vertical standing structure or/and an inclined standing structure.

In a specific manner, the vertical standing structure or/and the inclined standing structure include a contact surface that is in contact with the support surface; wherein, the vertical standing structure includes a second contact surface that allows the holding element to stand vertically, and the inclined standing structure The structure includes a first contact surface allowing the holding element to stand obliquely, and the first contact surface and the second contact surface are not on the same plane.

In a specific manner, the first contact surface and/or the second contact surface are located on the edge of the side wall of the holding element.

In a specific manner, the first contact surface and the second contact surface are formed by edges of side walls of the holding element.

In a specific manner, the first contact surface includes a surface formed by two edges of the side wall and a fulcrum formed by the intersection of one end of the surfaces formed by the two edges, wherein the surfaces of the two edges and the fulcrum form the first contact surface.

In a specific manner, the width of the surface formed by the two edges of the side wall is limited by the thickness of the side wall.

In a specific manner, the first contact surface is triangular in shape, and the second contact surface is triangular in shape.

In a specific manner, the test element carrier is located in the cavity of the holding element; wherein, the opening of the handle and the holding element have the same cross-sectional shape, and the cross-section is square, oval, rectangular, rhombus, pentagon, triangle , a hexagon, or a heptagon.

On the other hand, the utility model provides a device for collecting and detecting analyte in a fluid sample, the device comprising: a fluid sample collecting element; a test element carrier; and a holding element, wherein the test element carrier is located in the holding element.

In some preferred embodiments, the fluid sample collection element includes an absorbent element and a handle. In a preferred manner, the handle portion has a structure that cooperates with the opening of the holding element, so that when the fluid sample collection element is inserted into the holding element, the handle portion cooperates with the opening of the holding element, so that the fluid sample collection element is "held" in the holding element . In some preferred manners, both the handle portion and the opening of the holding element have a triangular structure. In a preferred manner, the handle portion has a structure that cooperates with the holding element, so that the fluid sample collection element is held in a relatively fixed position in the holding element. In some preferred manners, the handle portion has a protruding handle edge, which is matched with the opening edge of the holding element, so that the fluid sample collection element is in a relatively fixed position in the holding element. Preferably, the holding part and the holding element have matching locks, snaps, inserts, and bayonets, so that when the fluid sample collection element is inserted into the holding element, the fluid sample collection element is held in the holding element, or the fluid sample collection element is held in the holding element. The fluid sample collection element is in a relatively fixed position between the distance and the center. The so-called "holding" means that the collection element is inserted into the holding element after collecting the sample, and in one of the states, it is located in a relatively fixed position in the holding element, and cannot be further inserted into the holding element, nor can it be pulled out. Disengage the retaining element.

In some preferred forms, the absorbent element and the handle are connected by a rod. Preferably, the collecting element, the handle and the connecting rod are integrally structured. In some preferred forms, the fluid sample collection element includes a sealing element, when the fluid sample collection element is inserted into the holding element, the absorbent element is sealed with a cavity by the sealing element, so that the fluid in the absorbent element is sealed in a cavity in, without leaking to the external environment.

In some preferred modes, the test element carrier includes a body for accommodating the test element and a cavity for accommodating the absorbing element. Preferably, the test body includes a plurality of grooves for accommodating, placing and setting test elements. The cavity for accommodating the absorbing element includes a receiving cavity, which is surrounded by an opening, a side wall and a bottom. Among them, the opening of the receiving cavity allows the absorbing element to be inserted, and the side wall cooperates with the fluid sample collecting element including the sealing element so that the absorbing element is sealed in the containing cavity, and the bottom is in contact with the absorbing element, thereby extruding the fluid in the absorbing element sample. In a preferred manner, the bottom of the containment cell includes a through hole through which the squeezed fluid sample flows out of the containment chamber.

In some preferred manners, the body for accommodating the test element and the cavity for accommodating the absorbing element are integrally structured. The integral structure can be formed by integral injection molding, or can be formed by bonding the body for accommodating the test element and the cavity for accommodating the absorbing element by laser and adhesive reagents.

In some preferred forms, the bottom of the cavity forming the absorbing element extends outwards, thereby forming a bottom plate structure, a part of the bottom plate is the bottom of the cavity, and the other part is matched with the holding element, so that the test The component carrier is in a relatively fixed position in the holding component. Preferably, the bottom plate of the receiving chamber and the cavity of the holding element have substantially the same cross-section, preferably, the holding part of the fluid sample collection element, the bottom plate with strong accommodation, and the cavity of the holding element have substantially the same cross-section, such as a square , Oval, Rectangle, Rhombus, Pentagon, Triangle, Hexagon, Heptagon etc.

In some preferred modes, the holding element is a substantially triangular structure in cross section, and the holding element includes a first cavity and a second cavity, the first cavity is used to accommodate or hold the test element carrier, and the second cavity Used to collect or pool fluid samples on absorbent elements. In some preferred manners, the bottom plate of the test element carrier divides the cavity of the holding element into upper and lower cavities, and the upper cavity is the first cavity, which is close to the opening of the holding element and holds the test element carrier. The holding element is surrounded by an opening, a side wall and a bottom. The opening of the holding element is used to insert the fluid sample collection element and cooperate with the handle of the fluid sample collection element, so that the fluid sample collection element is in a relatively fixed position. The side wall includes multiple faces or one face, wherein the face facing the body of the nano-test element is transparent, so that the test results on the test element can be directly read through the transparent face. The other sides of the retaining element may or may not be transparent.

There are some structural designs on the side wall of the bottom of the first cavity of the holding element, which provides a fulcrum for the bottom plate of the receiving cavity on the test element carrier, so that the test element carrier is in a fixed position in the holding element, and at the same time , the bottom plate divides the cavity of the holding element into two cavities, the upper and the lower. The structure providing the fulcrum may be a protruding platform on the side wall, and there may be multiple or at least two platforms, or a fulcrum structure attached to other structures located in the cavity of the holding element. For example, the lower cavity of the holding element includes a structure for collecting fluid samples, which is located below the cavity for accommodating the absorbing element and also below the bottom plate of the storage cavity. Provide pivot. In some preferred manners, the fulcrums of the fulcrum structure are on the same plane, so that the bottom plates of the receiving chambers on the carrier are on the same horizontal plane.

In some other specific embodiments, the device further comprises a standing structure allowing the device to stand vertically and stand obliquely, wherein the standing structure is located on the holding element. Preferably, the vertical standing structure and the inclined standing structure are formed on the bottom edge of the side wall of the holding element, and the vertical standing structure and the inclined standing structure are in interchangeable standing states. Preferably, the vertical standing structure and the inclined standing structure are triangular contact surfaces, and the contact surface is used to contact the supporting surface; wherein, the vertical standing structure includes a second contact surface, and the inclined standing structure includes a first contact surface , the first contact surface and the second contact surface are not on the same plane.

On the other hand, the utility model provides a device for collecting and detecting an analyte in a fluid sample, the device comprising:

A fluid sample collecting element, wherein the fluid sample collecting element includes an absorbing element and a handle for absorbing a liquid sample, and a connecting rod connecting the absorbing element and the handle;

The test element carrier, wherein the test element carrier includes a body for carrying the test element and a housing cavity for accommodating the absorbing element, wherein the body and the housing cavity are integrally formed by injection molding;

A cavity-containing retaining element, wherein the cavity of the retaining element is bounded by the opening, the rim of the opening, and the side walls;

Wherein, the holding element includes a structure to allow it to stand upright and to stand obliquely.

In some specific embodiments, the vertical standing structure and the inclined standing structure are triangular contact surfaces, and the contact surface is used to contact the support surface; wherein, the vertical standing structure includes a second contact surface, and the inclined standing structure It includes a first contact surface, the first contact surface and the second contact surface are not on the same plane, wherein the second contact surface allows the holding element to stand vertically, and the first contact surface allows the holding element to stand obliquely.

In some specific embodiments, the vertical standing structure and the inclined standing structure are located on the edge of the side wall of the holding element.

In some specific embodiments, the first contact surface is formed by a surface formed by two edges of the side wall and a fulcrum formed by the intersection of one end of the surfaces formed by the two edges, wherein the surfaces of the two edges and The fulcrum forms a triangular first contact surface.

In some specific embodiments, wherein the test element carrier is located in the cavity of the holding element; wherein, the handle portion and the opening of the holding element have the same cross-sectional shape, and the cross-section is square, oval, rectangular, rhombus, pentagonal , triangle, hexagon, heptagon in a shape.

Beneficial effect

Using the device of the present invention not only can be manufactured at low cost, but also can make detection and reading results more convenient and fast, and the manufacturing cost is low.

Description of drawings

Fig. 1 is a schematic structural diagram of a sample collection element in a specific embodiment of the present invention.

Fig. 2 is an exploded schematic view of the detection and collection device of an embodiment of the present invention.

FIG. 3 is the test element carrier in FIG. 2 .

Fig. 4 is a schematic perspective view of the holding element after the test carrier element and the sample collection element are removed.

Fig. 5 is a longitudinal sectional view of the detection and collection device of an embodiment of the present invention during cooperating use.

Fig. 6 is a schematic diagram of a partial enlarged structure of the device shown in Fig. 5 .

Fig. 7 is a schematic diagram of reading the test results on the test element after the test is performed.

Fig. 8 is a schematic diagram of the "standing" structure of the holding element in one embodiment of the present invention.

Fig. 9 is a schematic diagram of the "standing" structure of the holding element in one embodiment of the present invention.

Fig. 10 is an actual use effect diagram of reading results after the holding element "stands up" in one embodiment of the present invention.

detailed description

The structures involved in the present invention or the technical terms used are further described below. These descriptions are only used as examples to illustrate how the method of the present utility model is realized, and cannot constitute any limitation to the present utility model.

detection

To detect means to assay or test for the presence of a substance or material such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolic product, a drug or a drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, protein or polymer. Additionally, detection means the amount of a substance or material tested. Further, assay also means immunoassay, chemical assay, enzyme assay, etc.

test element

Various test elements can be combined and applied in the utility model. The test elements include test strips, which can take various forms, such as immunological or chemical tests, for detecting analytes, such as drugs or related metabolites indicative of physical conditions, in a sample. In some forms, the test strip is an absorbent material having a sample application area, a reagent area and a test result area. The sample is added to the sample application area and flows into the reagent area by capillary action. In the reagent zone, the sample dissolves and mixes with reagents that can be used to detect the analyte (if the analyte is present in the sample). At this time, the sample with the reagent continues to flow to the detection result area. Additional reagents are immobilized in the test result area. These immobilized reagents in the detection zone react with and bind to the analyte, if present, or to the first reagent in the reagent zone. In a noncompetitive assay format, a signal is generated if the analyte is present in the sample, and no signal is generated if the analyte is absent. In a competition assay format, a signal is generated if the analyte is absent from the sample and no signal is generated if the analyte is present. The utility model is applicable to various analysis forms.

When the test element is a test strip, it can be made of absorbent or non-absorbent material, and a single test strip can use multiple materials for liquid transfer. One material of the test strip can be superimposed on another test strip material, for example, filter paper superimposed on nitrocellulose. Alternatively, a region of the test strip comprising at least one material is located behind another region of the test strip comprising at least one different material. In this case, the liquids are in communication between the regions, and they may or may not be superimposed on each other. The material on the test strip can be secured to a support such as a plastic liner or a hard surface to enhance test strip retention.

In some embodiments where the analyte is detected by a signal generating system (eg, at least one enzyme reacts specifically with the analyte), at least one signal-generating substance can be detected by the analyte adsorbed on the test strip zone, as described above specifically adsorbs on the material of the test strip. Additionally, signal-generating substances present in the sample application region, reagent region, analyte detection region, or throughout the test strip may be pre-treated on one or more materials of the test strip in advance. This can be done by adding a solution of a signal producing substance to the surface of the application area or by soaking one or more materials of the test strip in the signal solution. After the test strips have been added to the signal solution or soaked in the solution, dry the test strips. In addition, the above methods exist in the sample loading area, reagent area, and analyte detection area of the test strip, or the signal-generating substances throughout the entire test strip can be pre-treated on one or more materials of the test strip in advance. Alternatively, a signal substance present in the application area, reagent area, or detection area of the test strip may be added to one or more surfaces of the test strip material as a labeled reagent.

The regions of the test strip can be arranged as follows: a sample application region, at least one reagent region, at least one test result region, at least one control region, at least one adulteration detection region and a liquid absorption region. If the detection zone includes a control zone, preferably the control zone is located after the analyte detection zone of the test result zone. All or a combination of these zones can be on a single strip containing one material. Additionally, these zones are made of different materials and are joined together in the direction of fluid transfer. For example, the different regions may be directly or indirectly in fluid transfer. In this example, the different zones can be connected end to end in the direction of fluid transfer, or superimposed on each other in the direction of fluid transfer, or connected by other materials, such as connecting media materials (preferably absorbent materials such as filter paper, glass fibers or nitric acid). cellulose). When a connecting material is used, the connecting material can be a material comprising regions end-to-end, a material comprising regions end-to-end but not fluidly connected, or a material comprising regions overlapping each other (such as but not limited to de novo Overlapping to the end) but the liquid does not flow through the material, forming a liquid flow.

If the test strip contains an adulteration detection control zone, this zone can be placed before or after the result detection zone. When the result determination zone contains the control zone, the adulteration control zone is preferably placed before the control zone, which may not be the case. In one embodiment of the present invention, the test strip is a control test strip for adulteration analysis, judgment and/or control, and the adulteration control area can be located before or after the control area, preferably before the control area.

In a specific embodiment of the invention, a test element or a test strip may be located in a test element carrier. Preferably, in a groove of the body of the test element carrier.

sample

The samples that can be detected by the detection device of the present invention include biological fluids (such as case fluids or clinical samples). Liquid or fluid samples can be derived from solid or semi-solid samples, including excreta, biological tissue and food samples. Solid or semi-solid samples can be converted to liquid samples by any suitable method, such as mixing, mashing, macerating, incubating, dissolving or using enzymes in a suitable solution (such as water, phosphate solution or other buffer solution) Hydrolysis digests solid samples. "Biological samples" include samples of animal, plant and food origin, including for example urine, saliva, blood and its components, spinal fluid, vaginal fluid, sperm, feces, sweat, secretions, tissues, organs of human or animal origin , tumors, tissue and organ cultures, cell cultures and media. Preferably the biological sample is urine. Food samples include food processing substances, end products, meat, cheese, wine, milk and drinking water. Plant samples include any plant origin, plant tissues, plant cell cultures and media. "Environmental samples" are derived from the environment (eg, liquid samples from lakes or other bodies of water, sewage samples, soil samples, groundwater, seawater, and waste liquid samples). Environmental samples may also include sewage or other wastewater.

Any analyte can be detected using the present invention and a suitable detection element. Preferably, the utility model is used to detect drugs in saliva.

For example, the analyte detected by the utility model includes, but is not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormone (for example, human chorion, progesterone hormone, follicle stimulating hormone etc.), blood, white blood cells, sugars, heavy metals or toxins, bacterial substances (such as protein or carbohydrate substances targeting specific bacteria, such as E. coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L .monocytogenes, Vibrios, or Opuntia sp.) and substances in urine samples associated with physiological characteristics, such as pH and specific gravity. Any other clinical urine chemical analysis can use the lateral cross-flow detection form to cooperate with the device of the utility model for detection.

Analyte

Examples of analytes that can be contemplated in the present invention include haptenic substances including drugs (eg, drugs of abuse). "Drugs of Abuse" (DOA) refers to the use of drugs (usually to paralyze the nerves) for non-medical purposes. Abuse of these drugs can lead to physical and mental impairment, dependence, addiction and/or death. Examples of drugs of abuse include cocaine; amphetamine AMP (e.g., Black Beauty, White Amphetamine Tablets, Dextroamphetamine, Dextroamphetamine Tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal , speed); barbiturates BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (ie sleep aids); lysergic acid amide (LSD); inhibitors (downers, goofballs, barbs, blue devils, yellowjackets, methaphene); tricyclic antidepressants (TCAs, ie, imipramine, amitriptyline, and doxepin); dimethyldioxymethylaniline (MDMA); phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (ie, morphine MOP or, opium, cocaine COC; heroin, oxydihydrocodone); Sedative hypnotics, anti-anxiety drugs are a class of drugs mainly used to reduce anxiety, tension, fear, stabilize emotions, and have hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ, fusion diazepam NB23Cs, benzodiazepines, BZ receptor ligands, ring-opening BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolones, thiazides and Thiazole derivatives, other heterocycles, imidazole-type sedative/analgesic drugs (such as oxydihydrocodone OXY, methadone MTD), propylene glycol derivatives-carbamates, aliphatic compounds, anthracene derivatives, etc. The detection device of the utility model can also be used for detection of medical purposes but easy to overdose, such as tricyclic antidepressants (imipramine or similar) and acetaminophen. These medicines will be decomposed into different small molecular substances after being absorbed by the human body. These small molecular substances exist in blood, urine, saliva, sweat and other body fluids or some of the above-mentioned small molecular substances exist in body fluids.

sample collection element 100

The utility model also provides a fluid sample collection element 100 . In one embodiment, the fluid or liquid sample collection element has an absorbent element 103 and a handle 101 . The absorbent member 103 is generally made of medical grade sponge or foam plastic material commonly used in the art. But many other materials could also be used to form the absorbent element, such as cotton or paper, or any other material that has water-absorbing properties. The handle is generally rigid to facilitate handling of the absorbent element. The grip part 101 can be made of commonly used materials in the field, such as plastic, wood, metal or cardboard. In one embodiment, the handle part is connected to the absorbing element 103 through a rod-shaped structure 102, one end of the rod-shaped structure is connected to the handle part 101, and the other end includes a wheel edge 110 (see Figure 1), on which the absorbing element 103 is pasted. . In some specific embodiments, the wheel rim 110 includes a sealing element 108 , such as a silicone elastic sealing ring, for sealing the absorbing element 103 into the receiving cavity 3041 of the carrier 300 . In some implementation examples, the holding portion 101 includes a triangular structure in cross-section (see FIG. 1 ). The triangular handle 101 includes a surface 111 surrounding the triangular structure, and the surface 111 is provided with or includes a protruding edge 105 , and the protruding edge 105 may be formed continuously or discontinuously around the surface 111 . The edge 105 of the protrusion divides the surface 111 into two surfaces, the first surface 104 and the second surface 106. The edge 103 of the protrusion cooperates with the opening edge of the holding element 200, so that the handle 101 is fixed on the holding element. position, no further access to the cavity of the retaining element 200 is possible. The handle part can be a hollow structure, which does not appear bulky and is convenient to operate. At the same time, the protruding edge 105 provided on the grip part can not only play a role in restricting the position, but also allow the hand or fingers to grasp it more easily, because the protruding edge allows the surface 111 to have greater friction. In some specific embodiments, each side length of the triangular handle 101 is 2.5, 3, 4, 5 cm.

In some preferred manners, corresponding portions of the surface 106 of the handling portion 101 include protrusion structures 107 , 130 . Preferably, when the holding part is triangular, there are protruding structures on three sides, and the protruding structures cooperate with the grooves on the holding element to keep the holding part on the holding element 200, thereby providing a fixed position.

Test element carrier 300

The test element carrier of the present invention is mainly used for carrying the test element carrier 300 , which includes a body 308 for accommodating the test element. The body 308 includes two front and rear faces 310, 311, and a plurality of groove structures 301 are included on the front face 310 of the body, and test components can be arranged or placed in the grooves 301. In order to allow the test element to be placed in the slot structure 301 in a fixed manner and not easy to fall off, two pairs of protrusions 312 and 313 are provided in the slot structure 301 to keep the test element from falling out of the slot structure 301 . In some embodiments, the sample absorption area of the test element is exposed from the body, extends from an opening 3130 of the slot 301 , and directly contacts the fluid sample, and the detection area is located between the pair of protrusions 312 and 313 . In some ways, when the test element is placed in the groove 301, a layer of transparent sheet, such as plastic, aluminum foil, stickers, etc., is covered on the surface 310, so that the test strip is kept in a dry environment or protected from external environment. Influences such as the assembly process avoid accidental damage to the test strip. Of course, the sample absorbing area of the test strip may not expose the opening of the card slot.

In some specific embodiments, the carrier of the test element of the present utility model also includes a cavity 307 for accommodating the absorbing element 103, the cavity includes a cavity opening 304 and a side wall 317 and a bottom 318, the opening 304 and the side wall 317 and The bottom 318 defines a receiving chamber 3041 . A through hole 306 is included in the bottom 318 . The diameter of the through hole 306 can be smaller than the diameter of the absorbing element 103. When the absorbing element touches the bottom, it can be squeezed by force, so that the liquid sample absorbed on the absorbing element 103 can be squeezed out, thereby passing through the Holes 306 flow out. Preferably, the diameter of the through hole 306 is roughly equivalent to the diameter of the absorbing element 103, and a "cross" hollow structure is provided at the through hole, so that when the absorbing element touches the "hollow" connection structure at the bottom through hole, it can be Forced to be squeezed, so that the liquid sample absorbed on the absorbing element 103 is squeezed out, so as to flow out through the through hole 306 or out of the receiving chamber 3041 through the slit of the hollow structure.

In some preferred modes, the shape of the cavity 307 or the shape of the receiving cavity 3041 is equivalent to that of the absorbing element, but slightly smaller than the diameter of the absorbing element, but is equivalent to the wheel edge 110 of the fluid sample collection element 100, and the diameter on the wheel edge 110 The protruding elastic sealing ring cooperates with the inner surface of the side wall 317 of the receiving cavity 3041 of the cavity 307, so that the elastic sealing ring can contact the inner surface of the side wall 317 to form a seal, so that when the absorbing element is inserted into the receiving cavity 307 When the absorbing element enters the receiving cavity 3041, the sealing ring 108 forms a seal with the inner surface of the side wall 317, so that the absorbing element is sealed in the cavity 307, and the fluid sample will not flow out of the cavity 307 , so that the fluid can only flow out of the cavity 307 through the through hole 318 . The nature of this seal is at least liquid-tight, so that the fluid squeezed out from the absorbent element will not flow out of the cavity 307 through the opening 304 of the receiving cavity 3041, so that the fluid can only flow out of the cavity 307 through the through hole 318 .

In some preferred manners, the cavity 307 is integrated with the body 308 of the nanotest element, preferably, the cavity 307 and the body 308 are injection molded at one time. In some preferred forms, the bottom 318 of the cavity extends around to form a bottom plate 305, a part of the bottom plate is the bottom 308 of the cavity, and the other remaining part cooperates with the support structure in the holding element 200, so that the test element carrier 300 It is located at a fixed position in the holding element 200 . Preferably, the bottom plate 305 includes two contact surfaces 302, 303, the two surfaces 302, 303 are respectively located on both sides of the body 308 of the rectangular nano-test element, generally close to the opening of the test slot of the body 308, and generally located in one-third of the length direction of the body One position (Figure 2). Preferably, the bottom plate 305 has a triangular structure, and the two contact surfaces 302, 303 are respectively located at the two vertices of the triangle (see FIG. 2, FIG. 3), and the other corner is the third contact surface 385.

Since there is a card slot 301 on the body 308, the body has a certain thickness, and two surfaces 326, 325 are included below the two contact surfaces 302, 303 on both sides of the body. , 1291 is restricted, so that the body is fixed in the cavity of the holding element, preferably, the front face 310 of the body and the surface 1220 of the holding element 200 are relatively fixed.

holding element

In a specific embodiment, the holding element 200 of the present invention has the shape shown in Fig. 2, 4, of course, besides this structure, it can also have other suitable structures. The holding element 200 has an opening 212 and a side wall 220, surrounded by a bottom. The opening 212 has a retaining element opening rim 208 formed naturally by the thickness of the side walls. The edge 208 cooperates with the protruding edge 105 of the handling part 101 on the fluid collection element 100, so that the fluid collection element 100 can be inserted into a suitable position in the holding element 200, or a suitable fixed position (there will be a detailed introduction below) ). Preferably, near the opening 212 of the holding element 200, the inner surface of the side wall 220 has slightly recessed structures 209, 210, and the recessed structures cooperate with the corresponding protrusion structures 107, 130 on the surface 106 of the handle 101, when the handle 101 is inserted When reaching the opening of the holding element, the corresponding protruding structures 107, 130 on the surface 106 of the handle 101 "snap" into the slightly concave structures 209, 210 on the inner surface of the side wall 220, so as to indicate that it has entered the preset position . In this way, when the fluid sample collection element is inserted into the holding element 200, there are two structures to limit the position where the fluid sample collection element is inserted into the holding element, which has the effect of double insurance. Of course, if the holding part 101 has a triangular structure (FIG. 1), and the edge 208 of the opening of the holding element 200 is also a triangular structure, protrusions and recesses can be respectively provided on the three sides of the triangular structure to cooperate, so that the holding part 101 is fixed. in the holding element. Preferably, the holding part 101 can also function to seal the opening 212 of the holding element 200, preventing the reagent in the holding element from polluting the external environment.

In some specific embodiments, the retaining element 200 includes a fluid collection structure near the bottom (FIG. 5, FIG. 6), and the collection structure is generally located below the bottom 305 of the receiving chamber 3041 for receiving the absorbent element 103. Specifically, the collection structure is generally composed of an inclined plate 205, and one end 280 of the inclined plate 205 is in contact with the inner surface of the side wall 2220 and the side wall 3220 of the original element 200, and on the two side walls, the side wall 2220 and the side wall 3220 and the other end 281 is in contact with the inner surface of the side wall 1220 of the retaining element 200 downward. The other end 281 of the inclined plate 205 and the side wall 1220 are bent and folded into a groove 206, and the fluid sample flowing down from the plate 205 is collected in the groove 206, so that the fluid sample can be tested in the groove 206 and the groove. The absorbent regions of the elements are in contact, so that the fluid flows upward along the test element to complete the detection of the analyte in the fluid sample. Those skilled in the art, after reading the description of the utility model, have reason to believe that the inclined plate 205 can also change freely with the shape of the cross-section of the cavity of the holding element. For example, when the shape of the cross-section of the cavity of the holding element is triangular, the structure of the inclined plate 205 can also be triangular, but the plate 205 is inclined, so as to drain the fluid sample from the receiving cavity 3041 into the groove role.

In some preferred manners, the holding element 200 includes a cavity, which is divided into an upper cavity 201 and a lower cavity 202 by the bottom plate 305 of the receiving cavity 307 (shown in FIGS. 5 and 6 ). Preferably, the collecting structure is located in the lower cavity 202, the cavity 307 for accommodating the absorbing element is located in the upper cavity, and the body 308 for accommodating the test element occupies the upper cavity 201 and the lower cavity 202, wherein, the cavity with the test element One end of the absorption area is located in the lower cavity 202 and near the groove 206, which is convenient for contacting the fluid sample, while the other end of the body 308 containing the test element is located in the upper cavity 201, and the front 310 directly faces the side wall 1220, thereby When there is a test result, the test result on the test element can be read directly through the transparent side wall 1220 (such as the first surface 1220). The reading can be read by naked eyes, or by using a reading device. Direct reading, for example, can also be read with a mobile phone, a camera to take pictures, and a scanner to scan.

In order for the test element carrier to have a fixed position in the cavity of the holding element, one or more support structures can be arranged in the holding element to support the test element carrier. Specifically, there is a protruding surface 203 on the side wall of the holding element, and two surface columns 1204, 1291 are also provided at the two ends of the bottom 2061 of the groove 206. One end of the column is connected from the bottom of the groove, and the other end is upward. Extending, the other top forms supporting surfaces 204, 291 (omitted), and the three supporting surfaces 203, 204, 291 are respectively in contact with the contact surfaces 302, 303, 385 of the bottom plate 205 of the cavity containing the absorbing element, so that the bearing test element 300 is placed in the holding position. A fixed position in the component. In this way, the distance between the matching columns 1204, 1291 is equivalent to the width of the body 308 of the test element carrier. In this way, when the test element carrier 300 is inserted into the cavity of the holding element 200, the test element carrier 300 is precisely limited in the holding element. The specific position in the cavity, the distance between the columns 1204, 1291 limits the left and right position of the body 309 of the test element carrier, and the three support surfaces 203, 204, 291 limit the up and down position of the test element carrier.

More specifically, in some preferred manners, when the side wall of the holding element is surrounded by three faces and the cross section is triangular, the holding element 200 has three faces 1220 , 2220 , 3220 . Wherein, the front face 310 of the body 308 containing the test element carrying the test element 300 faces the first surface 1220 of the holding element 200, and at the same time, a groove 206 is provided at the bottom of the inside of the first surface, and a groove 206 is arranged at two ends of the groove respectively. The two uprights 1204, 1291 have a certain distance between the two uprights, which is equivalent to the width of the body 308 accommodating the test element. Two uprights 1204, 1291 extend upwardly from the trench bottom 3061, and the tops of the two uprights have two faces 204, 291 (omitted). When the shape of the bottom plate of the cavity 307 containing the absorbing element on the test element 300 is also triangular, the three contact surfaces 302, 303, 385 of the bottom plate 305 correspond to the three support surfaces 203, 204, 291 of the holding element 200. When the bearing test element 300 is inserted into the holding element 200, the three contact surfaces 302, 303, 385 of the bottom plate 305 are respectively in contact with the three supporting surfaces 203, 204, 291 of the holding element 200, and at the same time, the lower part of the body 308 accommodating the test element is inserted In this way, not only when the test element 300 is fixed in the holding element 200, but also the holding element 200 is divided into the upper cavity 201 and the lower cavity by the bottom plate of the receiving cavity 307 of the absorbing element 103. cavity 202 . Assembled is shown in Figures 5 and 6 (fluid sample collection element 100 removed).

For simple production and assembly, the holding element 200 with the three supporting surfaces 203, 204, 291 and the collection structure, such as the inclined plate 205, the groove 206 and two uprights 1204, 1291 respectively arranged at the two ends of the groove etc. can be molded at one time. The main body 308 for accommodating the test element, the accommodating cavity 307 for accommodating the absorbing component 103 and the bottom plate constituting the accommodating cavity 307 are integral structures, and they are also one-time injection molding. More specifically, a groove 301 for accommodating the test element is provided on the front 310 of the body 308 for accommodating the test element, and a cavity 307 for accommodating the absorbing element is arranged on the back 311, and one side of the bottom plate 305 is in contact with the back 311, or accommodates A part of the side wall of the cavity 307 is formed by a part of the rear surface 311 , or, the side wall 317 of the receiving cavity 307 is surrounded by itself without contacting the rear surface 311 of the body 308 . In this way, when assembling, the test element is first inserted into the draw-in groove 307 on the front 310 of the body 308, and then the test element carrier 300 is directly inserted into the holding element through the opening 212 of the holding element, thereby forming a very easy A detection device is provided, which includes a holding element 200 and a test element carrier 300 with a test element located therein, forming a structure as shown in FIGS. 5 and 6 (the fluid sample collection element 100 is removed).

Those skilled in the art, by reading the description of the utility model, have reason to believe that along with the difference in the shape of the cross-section of the cavity of the holding element, the structure of the bottom plate can also be changed freely, for example, the cavity of the holding element When the difference in shape of the cross-section is triangular, the structure of the bottom plate may also be triangular. Those skilled in the art, by reading the description of the utility model, have reason to believe that as the shape of the cross section of the cavity of the holding element is different, the structure of the handle part 111 of the fluid collecting element can also be changed freely, for example, holding When the shape of the cross section of the cavity of the element is triangular, the structure of the handle portion 111 of the fluid collection element may also be triangular. In addition to the handle portion 111 of the fluid collection element, the bottom plate 305 of the receiving cavity and the cross-section of the cavity 201 of the holding element 200 are the same shape, such as a triangle, they can also be other suitable shapes for mutual cooperation, for example, in some In a preferred manner, the bottom plate of the receiving cavity and the cavity of the holding element are substantially the same cross-section, preferably, the handle portion of the fluid sample collection element, the bottom plate with strong accommodation, the cavity of the holding element, and the inclined plate of the collection structure They are all substantially the same cut planes or connected shapes, such as squares, ellipses, rectangles, rhombuses, pentagons, triangles, hexagons, heptagons, etc.

standing structure

In some preferred manners, the device includes a standing structure, which can keep the detection device in a standing posture, so that the detection results on the test elements on the body 308 can be read conveniently through a transparent surface, such as 1220 . Preferably, the standing structure comprises a structure enabling the holding element to stand inclined. This standing structure comprises two faces 401 and 402, and these two are non-parallel faces (Fig. 8), and the intersection of these two faces 401 and 402 forms contact face 408 (also becomes intersection point), like this, two faces 401 and 402 and the intersection contact surface 408 form a contact surface similar to a triangle, and each surface of the triangle contact surface is in the same plane, and the plane formed by the triangle is not parallel to the plane on which the holding element stands vertically, but has a certain Angle, such as 30°; 25°; 45°, etc. When it is necessary to allow the holding element 200 to stand obliquely, the contact surface formed by the two surfaces 401 and 402 and their intersecting contact surface 408 is contacted with the support surface 500 (such as the surface of a test bench, a detection bench, and an operating table), They stand on these support surfaces stably and tiltedly, so that it is convenient to check and read the test results on the detection area of the test element, or directly use the reading device (mobile phone, camera) to take pictures and read, so as to save the test results ( Figure 10).

In order to better complete the detection, the standing structure may also include a structure allowing the holding element to stand vertically. In a preferred manner, standing planes 403, 404 and a standing point 407 are respectively formed at the two ends of the two faces 401 and 402. The planes 403, 404 and the standing point 407 form a similar triangular structure, and the planes 403, 404 and the standing point 407 are on the same plane. This allows the holding element 200 to stand upright on the table. Standing the holding element vertically facilitates the reaction and testing of the test element. And the structure that allows the holding element to stand obliquely can facilitate the reading of the test results.

The so-called vertical standing and inclined standing are relative concepts, generally relative to the supporting surface 500 in contact, when keeping far and near perpendicular to the supporting surface 500, it is generally standing vertically, and the holding element and the supporting surface 500 When there is a certain angle, it is called inclined standing (such as shown in Figure 10). Therefore, the first contact surface and the second contact surface themselves have a certain angle, such as an acute angle.

Vertical standing and inclined standing can be interchanged conveniently. For example, in the structure shown in FIG. When the triangular contact contacts the support surface 500, the holding element is allowed to stand obliquely, and the standing points 404, 406 and 407 form another second contact surface similar to a triangle, and the second contact surface is not on the same plane as the first contact surface. Instead, the second contact surface enables the holding element to stand upright. In a preferred manner, each point or surface forming the first contact surface and each surface or point forming the second contact surface are all formed at the bottom of the side wall of the holding element, and are directly surrounded by each surface 1220 of the side wall of the holding element. ,2220,3220 formed by cutting the bottom, no additional structure, which is convenient for low-cost production, such as one-time injection molding. The thickness of the side wall 220 can determine the size of the width of each edge constituting the contact surface. For example, the thicker the side wall is, the more the edges 401, 402, 408, 406, 406, and 407 defined by the side wall are, the more favorable it is to form a larger physical contact. noodle. In fact, due to the stable nature of the triangle, it can be known that as long as there are three points on the contact surface in contact with the support surface 500, it is possible to maintain a stable standing, such as standing vertically or standing obliquely. For example, the contact surface is not necessarily a solid planar structure, as long as several edges of the contact surface are formed, such as 401, 402, 408, 406, 406, and 407, they are distributed on the edges of the side walls. Because of the positional relationship, they can form surfaces of various shapes arbitrarily. Such as triangle, square, ellipse, rhombus, etc., the surface surrounded by these edges can make the holding element stand, for example stand vertically or stand obliquely.

When the detection is performed, in order to allow the holding element to stand upright, the second contact surface is brought into contact with the support surface 500 . After the detection is completed, when the holding element needs to be tilted, it only needs to be moved slightly (a force is given to make the holding element 200 tilt), and the holding element 200 is slowly tilted backward, so that the first contact surface and the support The surface 500 is in contact, thereby maintaining the inclination. Thus, they can be easily interchanged.

Those of ordinary skill in the art can easily understand that, in addition to the structure of the standing posture listed in the utility model, there are other similar structures that can make the holding element be in the vertical standing and inclined standing postures. Or, a similar design is adopted, so that the holding element can be changed from the state of standing upright to the state of inclined standing posture under different requirements, or from the state of inclined standing posture to the state of standing vertically. Because the vertical standing state is conducive to the reaction of the test element, and the state of the inclined standing posture is conducive to reading the test result on the test element, for example, it is very easy to read the test result on the test element by taking a photo, and it is convenient to save and read Get the result.

Detection method

How to detect the analyte in the fluid sample will be described below with reference to the accompanying drawings.

The fluid collection element 100 and the assembled detection device are prepared. The detection device includes a holding element 200 and a test element carrier 300 located in the holding element (as shown in FIGS. 5 and 6 ). The absorbent member 103 of the fluid collection member is put into the mouth of a person to collect saliva. When the entire absorbent tip is filled with saliva sample, the absorbent tip becomes soft. At this time, the collection element 100 that has absorbed the saliva sample is inserted into the upper cavity 201 of the holding element through the opening 212 of the holding element 200, and as the collection element 100 enters or is inserted, the absorption head enters the accommodation cavity of the accommodation cavity 307 In 3041, since the collecting element 100 has the sealing element 108, the sealing element 108 is in contact with the inner surface of the side wall 317 of the receiving chamber 3041, thereby forming a sealed state, thereby sealing the absorbing element 103 in the receiving chamber 304, as Further extruding, the saliva kept in the absorbent element 103 is squeezed out, and flows through the through hole 306 to the sloping plate 205 located in the lower cavity below, and the sloping plate collects the saliva sample into the groove 206, and is located in the groove. The absorption area of the test element in the test element contacts, so that the saliva sample rises along the test element due to capillary action, and flows to the detection area, so that the analyte is detected.

When the collection element 100 is inserted into the holding element 200, since the protruding edge 105 of the handling part 101 abuts against the edge formed by the opening 208 of the holding element, the collection element can no longer move downward, thereby completing the extrusion of the fluid sample. At the same time, the protruding structure 107 on the surface 106 of the handling part 101 of the collecting element 100 cooperates with the concave structure 209 on the inner surface of the side wall of the holding element, so that the collecting element is held in the holding element. In addition, since the sealing element on the collecting element 100 is in close contact with the inner surface of the side wall 317 of the receiving chamber 304, the collecting element 100 is more firmly held in the upper cavity 201 of the holding element, so that it is not easy to dislodge from the holding element. fall out.

At this time, the holding element relies on the standing structure of the bottom, for example, the second contact surface is in a vertical standing state, such as the standing point 407, and the planes 403, 404 and the standing point 407 form a triangular structure, so that the holding element 200 stands vertically. on the countertop. When it is necessary to take pictures of the test results on the test element on the front 310 of the body 308, the holding element is placed at an inclined angle (Fig. One contact surface touches the countertop, standing on the countertop obliquely is convenient for taking pictures.

After the pictures are taken, the whole test device can be discarded directly, because the holding element 200, the test element carrier 300 and the collecting element 100 are integrated into one structure. Thus, the leakage of the sample will not be caused, and the secondary pollution to the environment will not be caused.

Example 1

150 saliva samples were collected from 150 subjects using the sample collection element described herein by placing the absorbent element 103 of the sample collection element in the subject's mouth until it was full of saliva. After loading the sample, the sample collector is placed in the absorbent member receiving chamber 304 in the upper chamber 201 of the holding member 200 of the device to compress the absorbent member and extrude the sample for direct testing. The 50 negative samples were spiked with a cocktail of drugs of abuse, including amphetamines, cocaine, methamphetamine, opiates, THC and phencyclidine. Use the same method to absorb the liquid with the suction element 103, and perform the same operation. After 10 minutes, record the result as positive or negative. Three test strips are constructed on each body 308, each testing for three drugs of abuse. Between the three test strips, the following six drugs of abuse were tested: amphetamine (AMP), cocaine (COC), methamphetamine (MET), opiate (OPI), tetra-hydrocannabinol (THC), and phenylcyclo Capperidine (PCP).

All 100 samples that were not adulterated with drugs of abuse tested negative. For each of the six drugs, all 50 samples that had been spiked with the drug mixture provided positive results, although only 19 of the 20 samples tested positive for THC.

Confirmatory testing using widely accepted procedures is then performed on these samples. In confirmatory testing, all 50 samples tested positive for all six drugs.

Embodiment 2——detection sensitivity experiment

This embodiment is for the purpose of illustrating the detection sensitivity of the device and method of use of the present invention. Each sample solution was tested with ten devices for a total of 300 tests. These devices use a saliva sample on test strips that contain antigens from the drugs being tested. The test strip uses the competition method, with colloidal gold-labeled antibody in the label area and antigen on the test line.

The device simultaneously uses cocaine (COC), methamphetamine (MAMP), phencyclidine (PCP), tetrahydrocannabinol (THC) containing 0 times, 0.5 times, 1.5 times and 3 times the detection limit Morphine (MOP) or amphetamine (AMP) in PBS solution for detection. For example, the detection limit of THC in saliva is 4 ng/ml. Therefore, PBS solutions containing 0 ng/ml, 2 ng/ml, 6 ng/ml and 8 ng/ml of THC were tested. The table below shows the amount of drugs tested.

When testing, the above-mentioned negative saliva, PBS, or PBS spiked is absorbed by the absorbent sponge of the sample collector, and then extruded into the absorptive head receiving cavity for testing, allowing the liquid to enter the groove 206 to contact the test strip, and the liquid uses the capillary Function through test strips. The test results were recorded after 10 minutes and displayed in the table below.

The invention shown and described herein can be practiced in the absence of any element, limitation, specifically disclosed herein. The terms and expressions employed are used as terms of description and not of limitation, and there is no intention in the use of these terms and expressions to exclude any equivalents of the features shown and described or parts thereof, and it should be recognized that each All modifications are feasible within the scope of the present utility model. It should therefore be understood that while the invention has been specifically disclosed by way of various embodiments and optional features, modifications and variations of the concepts described herein may be employed by those of ordinary skill in the art and are considered to fall within within the scope of the invention as defined by the appended claims.

The contents of articles, patents, patent applications, and all other literature and electronically available information described or recorded herein are hereby incorporated by reference in their entirety to the same extent as if each individual publication were specifically identified Same as pointing out individually for reference. Applicants reserve the right to incorporate into this application any and all materials and information from any such articles, patents, patent applications, or other documents.

Claims (16)

1. a kind of device for detecting fluid analyte in sample matter, it is characterised in that the device includes：

Fluid sample gathering element, wherein, fluid sample gathering element includes absorbing the absorber element of fluid sample and is affectedly bashful portion, And connection absorber element and the connecting rod for being affectedly bashful portion；

Testing element carrier, wherein, testing element carrier includes for the body of bearing test element and absorbs member for housing The host cavity of part, wherein, body and host cavity are integrated the structure of injection molding；

Holding element containing chamber, wherein, the chamber of holding element is surrounded by the edge of opening and opening, and side wall；

Wherein, holding element includes the structure for allowing it to stand.

2. device according to claim 1, it is characterised in that the structure of standing includes standing structure or/and inclination Standing structure.

3. device according to claim 2, it is characterised in that described standing structure or/and inclination standing structure Including the contact surface contacted with supporting surface；Wherein, standing structure includes allowing the second contact surface of holding element standing, Tilting standing structure includes allowing holding element to tilt the first contact surface stood, and the first contact surface and the second contact surface be not same In individual plane.

4. device according to claim 3, it is characterised in that the first described contact surface or/and the second contact surface structure position In on the edge of the side wall of holding element.

5. device according to claim 3, it is characterised in that the first described contact surface and the second contact surface are by keeping member The edge of the side wall of part is constituted.

6. device according to claim 4, wherein, the first contact surface includes the face and two of two edges formation of side wall The one end in the face that individual edge is formed cross formed by fulcrum constitute, wherein, the face at described two edges and fulcrum are formed The first described contact surface.

7. device according to claim 5, wherein, the first contact surface includes the face and two of two edges formation of side wall The one end in the face that individual edge is formed cross formed by fulcrum constitute, wherein, the face at described two edges and fulcrum are formed The first described contact surface.

8. device according to claim 7, wherein, the width in the face of two edges formation of the side wall by side wall thickness Degree is limited.

9. device according to claim 3, wherein, described the first contact surface is shaped as triangle, the second contact surface Be shaped as triangle.

10. device according to claim 4, wherein, described the first contact surface is shaped as triangle, the second contact surface Be shaped as triangle.

11. device according to claim 5, wherein, described the first contact surface is shaped as triangle, the second contact surface Be shaped as triangle.

12. device according to claim 6, wherein, described the first contact surface is shaped as triangle, the second contact surface Be shaped as triangle.

13. device according to claim 7, wherein, described the first contact surface is shaped as triangle, the second contact surface Be shaped as triangle.

14. device according to claim 8, wherein, described the first contact surface is shaped as triangle, the second contact surface Be shaped as triangle.

15. device according to claim 1, wherein, testing element carrier is located in the chamber of holding element；Wherein, it is affectedly bashful Portion, shape of the opening with identical cross section of holding element, cross section is square, ellipse, rectangle, rhombus, five sides A kind of shape in shape, triangle, hexagon, heptagon.

16. a kind of device for detecting fluid analyte in sample matter, it is characterised in that the device includes：

Fluid sample gathering element, wherein, fluid sample gathering element includes absorbing the absorber element of fluid sample and is affectedly bashful portion, And connection absorber element and the connecting rod for being affectedly bashful portion；

Testing element carrier, wherein, testing element carrier includes for the body of bearing test element and absorbs member for housing The host cavity of part, wherein, body and host cavity are integrated the structure of injection molding；

Holding element containing chamber, wherein, the chamber of holding element is surrounded by the edge of opening and opening, and side wall；

Wherein, holding element includes the structure for allowing it to stand；The structure of described standing includes standing structure and tilted to stand Vertical structure；Described standing structure and inclination standing structure includes the contact surface contacted with supporting surface；

Wherein, standing structure includes allowing the second contact surface of holding element standing, and tilting standing structure includes allowing guarantor The first contact surface of organs incline standing is held, the first contact surface and the second contact surface be not in approximately the same plane；

Wherein, the angle of the first described contact surface and the second contact surface one acute angle of formation.