CN111272481A - Detection box - Google Patents

Abstract

The invention provides a detection box, which comprises a fluid sample collection cavity, a detection component and a detection component, wherein the collection cavity comprises an opening, a test element is arranged in the collection cavity, and the test element is used for testing whether an analyzed substance exists in a fluid sample; the detection box also comprises a cover body used for covering the opening of the collection cavity, wherein the cover body comprises a buckle structure used for clamping the opening of the collection cavity, and when the cover body covers the opening of the collection cavity, the buckle structure is clamped with the outer wall of the opening of the collection cavity, so that the cover body is fixed on the collection cavity. The invention adopts the form that the cover body and the collection cavity are covered, the cover body and the bottle body are easily covered and difficult to separate through the arrangement of the buckle structure, and compared with the traditional threaded rotating mode of the cover body and the collection cavity, the invention has the advantages of convenience and rapidness, and the detection efficiency is accelerated; the sampling hole is arranged on the side surface of the collection cavity and is close to the corner part, so that a test strip or a test element on the carrier can be avoided, and the sampling hole is prevented from being blocked by a sample application area of the test strip or the test element during secondary sampling.

Description

a detection box

technical field

The invention relates to the technical field of in vitro rapid detection, in particular to a device for collecting and detecting analytes in liquid samples in the field of rapid diagnosis, such as urine and saliva collection and detection boxes.

Background technique

The following description of the background art is only the introduction of some background common sense, and will not constitute any limitation to the present invention.

At present, test kits used to detect whether a sample contains analyte substances are widely used in hospitals or at home. These test kits for rapid diagnosis contain one or more test strips, such as early pregnancy detection, drug abuse detection, etc. Wait. This rapid diagnostic test kit is very convenient, and the test result can be obtained on the test strip in one minute, or at most ten minutes.

Drug detection is widely used, and is often used in anti-drug departments, public security bureaus, drug rehabilitation centers, physical examination centers, national military recruitment physical examination offices and other institutions. Drug testing is varied and frequent. Some need to collect samples, and then need professional testing institutions or testing laboratories for testing. Some need to complete on-site testing in a timely manner. For example, people who drive after taking drugs (referred to as "drug drivers") need to conduct on-site testing, and then obtain the test results in a timely manner. For drug testing, samples can be urine, sweat, hair and saliva samples.

The testing of saliva samples is gradually accepted and welcomed by testing institutions or testing personnel based on the convenience of collection. Various sample collection and testing devices for clinical or domestic use have been seen and described in some literature. For example, US Pat. No. 5,376,337 discloses a saliva sample collector in which a filter paper is used to collect saliva from a subject's mouth and deliver the saliva to an indicator reagent. US Patents US 5,576,009 and US 5,352,410 each disclose a syringe-type fluid sample collector.

A drug detection device is also described in US Pat. No. 7,927,562. The cover of the device is fitted with a collection device with a test strip in the form of a thread. Although this kind of threaded seal can achieve the purpose of sealing the collection chamber, it is still not convenient in operation, especially when there are many samples to be tested, it is inconvenient and inefficient to rotate. For another example, another drug detection device is also described in US Pat. No. 9,462,998. A raised sheet is provided on the cover. When the cover is inserted into the cavity, the sheet is in contact with the inner wall of the collection cavity, so that the cover can be easily removed. The body remains on the collection chamber, limiting its position. The thin sheet structure provided by such a device is not easy to realize in actual product design and production, mainly because the mold production of plastic parts is difficult.

Therefore, it is necessary to improve the existing traditional detection box to provide a device for collecting samples and performing detection in a simpler manner.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a detection box to solve the above-mentioned problems in the background art.

In order to achieve the above object, the technical scheme adopted by the present invention is a detection box, which includes: a fluid sample collection cavity, the collection cavity includes an opening, and a test element is arranged in the collection cavity, and the test element is used to test whether the fluid sample is There is the analyte; the detection box also includes a cover for covering the opening of the collection cavity;

Wherein, the cover body includes a snap structure for snapping the receiving cavity opening. When the cover body covers the collecting cavity opening, the snap structure snaps to the outer wall of the receiving cavity opening, so that the cover body is fixed on the collecting cavity.

Further, the outer wall of the collection cavity includes a raised structure, and when the cover body is closed to the opening of the collection cavity, the buckle structure snaps to the raised structure. As a preferred technical solution, the outer wall of the collection cavity has a box-shaped raised structure. .

Further, there are at least two buckle structures in the cover body, and the buckle structures are at right angles or straight lines. Right angle, the protruding structure cooperates with the four buckle structures, so that when the cover body is closed to the opening of the collection cavity, the cover body is less likely to be separated from the collection cavity.

Further, the cover body is provided with a holding part, which is convenient for the operator to exert force on the cover body; the holding part is integrally formed with the cover body, which is convenient for processing;

Further, the bottom of the collection cavity is raised upwards, which can disperse the liquid samples in the collection cavity to the surrounding and make full contact with the test element, which can reduce the sampling quantity of the liquid samples without affecting the test results.

Further, the buckle structure includes a lower buckle surface and an upper buckle surface, and the angle formed by the lower buckle surface and the horizontal plane is greater than the angle formed by the upper buckle surface and the horizontal plane, so the slope of the lower buckle surface is greater than the slope of the upper buckle surface, When the cover body and the collection cavity need to be closed, due to the large slope of the lower buckle surface, the contact between the lower buckle surface and the raised structure makes the process of closing the cover body and the collection cavity relatively easy, and there is a slow elastic deformation between them. process, therefore, requires less force. It is specifically reflected in the feeling of the operator when it is buckled: it can be buckled by gently pushing it. When the cover body and the collection cavity need to be separated, due to the small slope of the upper buckle surface, the contact between the upper buckle surface and the raised structure makes the separation process of the cover body and the collection cavity relatively difficult, which is a process of rapid elastic deformation. , which is embodied in the operator's feeling when they separate: need to use a large force to separate.

Further, the cover body is square, the limit clips are arranged on the inner wall of the cover and the corners of the cover body, the cover body is provided with limit clips, and the limit clips include a first limit part and a second limit part The first limiting part limits the protruding structure to keep the lid stable on the bottle body, and the second limiting structure limits the opening of the collection cavity, so that the top of the bottle body is embedded in the lid body and cannot be shaken.

Further, the lower buckling surface is a smooth surface, and the raised structure on the collecting cavity includes an upper buckling surface and a lower buckling surface, wherein the upper buckling surface contacts the lower buckling surface and guides the lower buckling surface to contact the upper buckling surface.

Further, the detection box also includes a carrier, the carrier has a plurality of card slots for setting test elements, the carrier is located in the collection cavity, the carrier has a cavity, and the carrier has a bottom, and the bottom of the carrier is provided with a through hole, the carrier, the collection cavity The cavity is square, and the side of the collection cavity is provided with a sampling hole near the corner, which can avoid the test strip or test element on the carrier, prevent the sample application area of the test strip or test element from blocking the sampling hole during secondary sampling, and at the same time from the sampling hole. Sampling directly from the wells avoids contamination of the sample during sampling.

Further, the cover body is also provided with a sample collector, and the sample collector is used to be inserted into the cavity in the carrier and contact with the bottom of the carrier.

Further, the sample collector is provided with an annular groove, a sealing ring can be installed in the annular groove, and the sealing ring can be sealed with the collection chamber.

Further, the bottom of the carrier is provided with a second boss, the second boss is in the shape of a box, and the bottom of the collection cavity is provided with a support member, and the support member supports the four corners of the second boss.

To sum up, the beneficial effects of the present invention are as follows: the detection box provided by the present invention adopts the form in which the cover body and the collecting cavity are closed, and the cover body and the bottle body are easily closed by the arrangement of the buckle structure, but difficult to separate, and the cover body and the bottle body are easily closed. The cover method of the body and the collection cavity and the traditional screw rotation method of the cover body and the collection cavity have the advantages of easy operation, squeeze the absorption element, and improve the detection efficiency, but relatively speaking, in the repeated detection process, the thread The rotation method is much more complicated and difficult to operate than the technical solution provided by the present invention; a plurality of grooves are arranged on the outer surface of the carrier, which can be used to install different test elements and realize the functions of multiple detections at a time; the bottom of the bottle body The upward bulge can disperse the liquid sample in the collection chamber to the surrounding area and make full contact with the test element, which can reduce the sampling quantity of the liquid sample without affecting the test result; the first and second bosses on the carrier are connected to the The limit buckles and supports in the collection cavity are matched, so that the carrier can be installed in the collection cavity to keep stable and not easy to fall off; the sampling hole is located on the side of the bottle body (collection cavity) near the corner, which can avoid the test strip or test on the carrier. It prevents the sample application area of the test strip or the test element from blocking the sampling hole during secondary sampling, and direct sampling from the sampling hole can prevent the sample from being polluted during sampling; the sealing ring on the connecting end of the sample collector is in contact with the inner wall of the collection cavity , forming a sealing area, which can prevent the liquid sample from leaking from the collection chamber or from the carrier when the detection box is shaken violently or inverted.

Description of drawings

Fig. 1 is the structural representation of carrier;

Fig. 2 is the structural representation of bottle body;

Figure 3 is an exploded view of the detection box;

Fig. 4 is the bottom structure schematic diagram of detection box;

Figure 5 is a top view of the bottle body;

Figure 6 is an exploded view of the sample collector;

Fig. 7 is the connection relation diagram when the cover body, the carrier and the bottle body are cut open;

8 is a schematic structural diagram of a cover body;

Fig. 9 is the half-section schematic diagram of cover body;

10 is a schematic diagram of the overall structure of a detection box;

Fig. 11 is the partial enlarged schematic diagram of "A", "B" area in Fig. 7;

FIG. 12 is a partial enlarged schematic view of the regions “C” and “D” in FIG. 7 .

Detailed Description

The structures involved in the present invention or the technical terms used are further described below. If there is no special indication, they should be understood and interpreted according to the general terms commonly used in the art.

detect

Detection means assaying or testing for the presence of a substance or material such as, but not limited to, chemicals, organic compounds, inorganic compounds, metabolites, drugs or drug metabolites, organic tissue or metabolites of organic tissue, nucleic acids, protein or polymer. In addition, detection refers to the quantity of a test substance or material. Further, the assay also means immunoassay, chemical assay, enzymatic assay, and the like.

sample

The kits or collected samples of the present invention include biological fluids (eg, patient fluids or clinical samples). Liquid samples or liquid samples, or fluid samples or fluid samples, can be derived from solid or semi-solid samples, including excreta, biological tissue and food samples. A solid or semi-solid sample can be converted to a liquid sample by any suitable method, such as mixing, mashing, macerating, incubating, dissolving or using enzymes in a suitable solution (eg water, phosphate solution or other buffer solution) Digestion of solid samples. "Biological samples" include animal, plant and food samples, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, of human or animal origin, Organs, tumors, tissues and organ cultures, cell cultures and media. Preferably the biological sample is urine, preferably the biological sample is saliva. Food samples include food-processed substances, final products, meat, cheese, wine, milk and reference water. Plant samples include those derived from any plant, plant tissue, plant cell culture and media. "Environmental samples" are derived from the environment (eg, liquid samples from lakes or other bodies of water, sewage samples, soil samples, groundwater, seawater, and waste liquid samples). Environmental samples may also include sewage or other waste water.

Any analyte can be detected using a suitable detection element or test element of the present invention. Preferably, the present invention is used to detect small drug molecules in saliva and urine. Of course, any of the above forms of samples can be collected using the cartridge of the present invention, whether initially solid or liquid, as long as these liquids or liquid samples can be absorbed by the absorbing element. The absorbent element here is generally made of water-absorbing material, which is initially dry, and can absorb liquid samples or fluid samples through the capillary or other properties of the material of the absorbent element. The absorbent material can be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, non-woven fabric, cotton, polyester film, yarn, and the like. Of course, the absorbent element does not have to be made of absorbent material, it can be made of non-absorbent material, but there are holes, threads, holes on the absorbent element, and samples can be collected on these structures. These samples are generally solid or semi-solid samples. These samples are Fill between threads, holes, or holes.

downstream and upstream

Downstream or upstream is divided for the direction of liquid flow, generally the liquid flows from the upstream to the downstream area. The downstream region receives liquid from the upstream region, and the liquid can also flow along the upstream region to the downstream region. This is generally divided according to the direction of liquid flow. For example, on some materials that use capillary force to promote liquid flow, the liquid can flow in the opposite direction of gravity. At this time, the upstream and downstream are still divided according to the flow direction of the liquid. .

Gas communication or liquid communication

Gas communication or liquid communication means that liquid or gas can flow from one place to another, and may pass through some physical structures to guide the flow. The so-called physical structure generally refers to the liquid passing through the surface of these physical structures, or the internal space of these structures and passively or actively flowing to another place. Passive is generally the flow caused by external force, such as capillary action. flow. The flow here can also be a liquid or gas due to its own action (gravity or pressure), or it can be a passive flow. The connection here does not necessarily mean the existence of liquid or gas, but only indicates the connection relationship or state between two objects in some cases. If there is liquid, it can flow from one object to another. This refers to the state in which two objects are connected. On the contrary, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, such a state It is a state of non-communication, non-liquid or gas communication.

test element

The so-called "test element" here refers to the element that can detect the sample or whether the sample contains the analyte of interest. It can be called the test element. This detection is based on whatever technical principle, immunology, chemistry, electricity, Optical, molecular, nucleic acid, physics, etc. The test element can be selected as a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention.

Various test elements can be used in combination with the present invention. One form is test strips. Test strips for analysis of analytes (eg, drugs or metabolites indicative of medical conditions) in a sample can be in various formats, such as in the form of immunoassays or chemical assays. The test strips can be analyzed in a non-competitive or competitive mode. The test strip generally includes a water-absorbing material with a sample application area, a reagent area and a test area. Add the sample to the sample application area and flow to the reagent area by capillary action. In the reagent area, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized in the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte in this zone, or bind to one of the reagents in the reagent zone. The label used to display the detection signal is present in the reagent zone or separate label zone.

In a typical non-competitive assay mode, a signal is generated if the analyte is present in the sample, and no signal is generated if the analyte is not present. In the competition method, a signal is generated if the analyte is not present in the sample, and no signal is generated if the analyte is present.

The test element can be a test paper, and a material that absorbs or does not absorb water can be selected. Test strips can include a variety of materials for liquid sample transfer. One of the test paper materials can be overlaid on another material, such as filter paper overlaid on a nitrocellulose membrane. One area of the test strip can be selected from one or more materials, while the other area can be selected from other different materials or materials. Test strips can be adhered to a support or hard surface to improve the strength of the test strips.

The analyte is detected by a signal generating system, such as using one or more enzymes that specifically react with the analyte, using the method of immobilizing the specific binding substance on the detection test paper as described above, and combining one or more enzymes. The composition of the signal generating system is immobilized on the analyte detection area of the test strip. The signal-generating substance may be in the sample application area, the reagent area, or the detection area, or the entire test strip, and the substance may impregnate one or more materials of the test strip. The signal-containing solution is added to the surface of the test paper or one or more materials of the test paper are immersed in the signal-containing solution. The test paper to which the signal containing solution was added was allowed to dry.

The various areas of the test strip can be arranged in the following ways: sample addition area, reagent area, detection area, control area, determination of whether the sample is adulterated or not, and liquid sample absorption area. The control area is located after the detection area. All zones can be arranged on a strip of test strips using only one material. It is also possible to use different materials for different zones. Each zone can be in direct contact with the liquid sample, or different zones can be arranged according to the direction of the liquid sample flow, and the end of each zone can be connected and overlapped with the front end of another zone. The material used can be a material with better water absorption such as filter paper, glass fiber or nitrocellulose membrane. Test strips can also take other forms.

The commonly used reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. . For example, the following patents describe reagent strips or devices containing reagent strips: US 4,857,453; US 5,073,484; US 5,119,831; US 5,185,127; US 5,275,785; US 5,766,961; US 5,770,460; US 5,916,815; US 5,976,895; US 6,248,598; US 6,140,136; The test strips disclosed in the above patent documents and similar devices with test strips can be used in the test element or the detection box of the present invention to detect the analyte, such as the detection of the analyte in the sample.

The detection reagent strips used in the present invention may be so-called lateral flow test strips. The specific structures and detection principles of these detection reagent strips are well known to those skilled in the art in the prior art. A common detection reagent strip includes a sample collection area or a sample application area, a labeling area, a detection area and a water absorption area. The sample collection area includes a sample receiving pad, and the labeling area includes a labeling pad. Including the necessary chemical substances that can detect whether the analyte is contained, such as immunological reagents or enzymatic chemical reagents. The commonly used detection reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Etc., of course, a detection result control area may also be included downstream of the detection area. Usually, the control area and the detection area appear in the form of horizontal lines, which are detection lines or control lines. Such detection reagent strips are traditional reagent strips, and of course, other types of reagent strips that utilize capillary action for detection can also be used. In addition, the general detection reagent strip has dry chemical reagent components, such as immobilized antibodies or other reagents. When encountering liquid, the liquid flows along the reagent strip with capillary action, and with the flow, the dry reagent components are dissolved in the The liquid, thus proceeding to the next zone for processing, reacts with the dry reagents in that zone to perform the necessary detection. Liquid flow occurs primarily through capillary action. All of them can be applied to the detection box of the present invention, or arranged in the detection chamber to contact the liquid sample, or used to detect the presence or quantity of the analyte in the liquid sample entering the detection chamber.

Except that the above-mentioned test strip or the lateral flow test strip itself is used to contact the liquid sample to test whether the liquid sample contains the analyte. In some preferred manners, the test elements can also be arranged on some carriers, as shown in FIG. 1 , for example, some carriers 40 , the carrier has many grooves 43 , and the test elements are located in the grooves 43 . In some implementations, the carrier 40 includes a recessed area in which the test elements are disposed, and a plurality of recesses are disposed in the area, each recess may be disposed with a test strip, and each test strip may detect an analyte. Specifically, as shown in FIGS. 1-3 , the carrier 40 is in a form matching the collection cavity 22 . When the collection cavity 22 is square, a square carrier can be placed in the collection cavity 22 , and a plurality of grooves are arranged on the outer surface of the carrier 40 . 43. A test element is placed in the groove 43, and the test element can be a test strip. The groove 43 is provided with an installation sharp corner 45, which can clamp the test strip to prevent the test strip from falling off when the test strip is installed. In some ways, after the test element is arranged in the groove of the carrier, a transparent film is covered on the carrier, one is to seal the groove area of the carrier, and the transparent film is easy to observe the test results on the final detection area. The transparent film can also be a transparent plastic sheet, which is only transparent in the test area.

Generally, the test strip includes a sample application area, a marking area and a detection area. When placing the test strip, the sample application area is placed close to the bottom of the carrier, and then the groove is slightly exposed, such as 2-3 mm, reserved Part of the sample application area is used to absorb the liquid sample flowing into the bottom of the collection chamber. Typically, the sample application area is located upstream of the labeling area, which is located upstream of the detection area.

Carrier and collection chamber

The collection cavity is a place for accommodating samples. Specifically, as shown in FIGS. 1-3 , the bottle body 20 is provided with a collection cavity 22 . The collection cavity 22 includes an opening on the upper side of the bottle body 20 . The opening is inserted into the collection chamber 22 . In some ways, the carrier 40 mates with the collection chamber 22 . Specifically, when the collection cavity 22 is square, a square carrier 40 can be placed in the collection cavity 22 . The upper end of the carrier 40 protrudes outward to form a first boss 42 , and the first boss 42 is in contact with the inner wall of the collection cavity 22 . , so that the carrier 40 will not shake after being loaded into the collection cavity 22. The collection cavity 22 is provided with a limit buckle 25. After the carrier 40 is completely inserted into the collection cavity 22, the carrier 40 is blocked by the limit buckle 25, and it is not easy to get out of the collection cavity 22. The collection cavity 22 falls out. When the carrier 40 is inserted into the collection cavity 22, the first boss 42 may collide with the limit buckle 25. In order to facilitate the insertion of the carrier 40 into the collection cavity 22, refer to FIG. In FIG. 12 , the lower end of the first boss 42 is inclined. Correspondingly, the upper surface of the limit buckle 25 is curved or inclined. In order to prevent the carrier 40 from falling out of the collection cavity 22 easily, the upper end of the first boss 42 is flat. , in order to prevent the carrier 40 from being inserted into the collection cavity 22 and cannot be taken out, the lower surface of the limit buckle 25 is inclined. In addition, as shown in FIG. 1 , the bottom of the carrier 40 is provided with a second boss 46 , correspondingly, as shown in FIG. , the bottom of the collection cavity 22 is provided with a support member 29, the second boss 46 is in the shape of a box, and the support member 29 is set at the four corners of the bottom of the collection cavity 22 to support the four corners of the second boss 46, and the limit buckle 25 The carrier 40 and the support member 29 limit the position of the carrier 40 from the upper and lower sides respectively, so that the carrier 40 is not easily shaken when installed in the collection cavity 22 . In some preferred manners, the side surface of the second boss 46 has a certain slope, and the frame area of the lower part of the second boss 46 is smaller than the frame area of the upper part of the second boss 46 . The two bosses 46 are more easily inserted between the support members 29 , and at the same time, a pre-tightening force is generated between the second bosses 46 and the support members 29 , so that the carrier 40 is not easily dropped when installed in the collection cavity 22 .

There are grooves 43 evenly distributed on the outer surface of the carrier 40, and test elements are installed in the grooves 43. In addition to the test elements, the carrier also has the function of squeezing the sample collector and sending the sample into the collection cavity, as shown in Figure 1-3. As shown, the carrier 40 is in the shape of a barrel with an opening on the upper side. The sample collector 30 is inserted into the carrier 40 along the opening on the upper side of the carrier 40, and is pressed against the bottom of the carrier 40, and the sample is squeezed from the sample collector. The bottom of the carrier 40 is provided with a plurality of through holes 44, so that the space inside the carrier 40 is communicated with the collection cavity 22, the groove 43 is equipped with a detection test paper, and the lower end of the detection test paper is in contact with the bottom of the collection cavity 22. Or very close to the bottom of the collection chamber 22 , the sample inside the carrier 40 flows into the collection chamber 22 through the through hole 44 and contacts with the detection test paper to start the detection.

The bottle body 20 is provided with a sampling hole 26 near the bottom. Specifically, as shown in FIG. 3 and FIG. 10 , the sampling hole 26 is used for the secondary sampling and re-inspection of the liquid sample. The sampling hole 26 is located on the side of the bottle body 20 (collection cavity 22) near the corner, because when the bottle body 20 is in a square shape, the carrier 40 is also in a square shape, and the corner position of the carrier 40 cannot be slotted to install a test strip or The test element can prevent the sample application area of the test strip or the test element from blocking the sampling hole 26, and at the same time, the sample is directly extracted from the sampling hole 26 of the bottle body 20 to avoid contamination of the sample during secondary sampling. In some manners, the sampling holes 26 are paired with sampling plugs 27 . As shown in FIG. 4 , the sampling plugs 27 can prevent the liquid sample from flowing out of the sampling holes 26 . In some preferred manners, the bottom of the bottle body 20 is provided with a chute 28 at the position where the sampling plug 27 is assembled, and the chute 28 can facilitate the inspector to remove the sampling plug 27 .

The bottom of the bottle body 20 protrudes upwards 438 , which can disperse the liquid samples in the collection chamber 22 around and fully contact the test paper, thereby reducing the number of liquid samples without affecting the test results.

analyte

Examples of analytes that can be used in the present invention include small molecules, including drugs (eg, drugs of abuse). "Substance of Abuse" (DOA) refers to the use of drugs (usually to paralyze nerves) for non-medical purposes. Abuse of these drugs can lead to physical and mental damage, dependence, addiction and/or death. Examples of drugs of abuse include cocaine; amphetamines AMP (eg, black beauty, white amphetamine tablets, dextroamphetamine, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal , speed); barbiturates BAR (eg, Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (ie, sleep aids); lysergic acid diethylamide (LSD); inhibitors (downers, goofballs, barbs, blue devils, yellow jackets, meprodol); tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline, and doxepin); MDMA; phencyclidine pyridine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e. morphine MOP or, opium, cocaine COC; heroin, oxycodone); Anxiety drugs and sedative-hypnotics, anti-anxiety drugs are a class of drugs mainly used to reduce anxiety, tension, fear, stabilize emotions, and have both hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ, Fusion diazepine NB23Cs, benzoazepines, ligands for BZ receptors, ring-opening BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, Thiazine and thiazole derivatives, other heterocycles, imidazole-type sedative/analgesics (such as oxydihydrocodeinone OXY, methadone MTD), propylene glycol derivatives - carbamates, aliphatic compounds, anthracene derivatives Wait. The detection kit of the present invention can also be used for the detection of overdose which belongs to medical use but is easy to take, such as tricyclic antidepressants (imipramine or the like) and acetaminophen. These drugs are metabolized into small molecular substances after being absorbed by the human body. These small molecular substances exist in blood, urine, saliva, sweat and other body fluids or in some body fluids.

For example, analytes detected with the present invention include, but are not limited to, creatinine, bilirubin, nitrite, proteins (non-specific), hormones (eg, human villi-stimulating hormone, progesterone hormone, follicle stimulating hormone, etc. ), blood, leukocytes, sugars, heavy metals or toxins, bacterial substances (such as proteins or carbohydrates against specific bacteria, such as e.g. Escherichia coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L. monocytogenes, Vibrio, or Cactobacillus) and urine samples for substances related to physiological characteristics, such as pH and specific gravity. Any other clinical urine chemical analysis can be detected in the form of lateral lateral flow detection with the device of the present invention.

flow of liquid

The flow of liquid usually refers to the flow from one place to another. Under normal circumstances, the flow of liquids in nature mostly depends on the action of gravity to flow from high to low. The flow here also depends on external force, that is, external gravity. The flow under circumstances can become the flow of natural gravity. In addition to gravity, the flow of liquids can overcome gravity and move from low to high. For example, the extraction of liquid, or the compression of liquid, or the flow of liquid from the bottom to a high place under pressure, or the flow of the customer's liquid's own gravity due to the concern of pressure. For example, the liquid sample in the carrier 40 will enter the collection chamber 22 through the through hole 44 at the bottom of the carrier 40 under the action of gravity, and the liquid sample contacts the lower end of the test strip on the carrier 40 to start flowing bottom-up by capillary force.

sample collector

The sample collector is used to collect samples. Specifically, as shown in FIG. 6 , the sample collector 30 includes a connecting end 31 , a rod body 32 , and a sampling end 33 . The connecting end 31 includes a cross connector 34 and a pressing table 37 . The end of the cross connector 34 It gradually becomes sharper to facilitate the connection between the cross connector 34 and the cover body 10. The sampling end 33 is used to connect the absorbing element. The absorbing element can be made of a non-toxic sponge with strong water absorption. The absorbing element and the sampling end 33 can be bonded by special glue. , the connecting end 31 is provided with an annular groove 35, and a sealing ring 36 is installed in the annular groove 35. When the sample collector 30 is inserted into the carrier 40 along the opening on the upper side of the carrier 40, the absorbing element (not shown) on the sampling end 33 out) and the bottom of the carrier 40 is squeezed, the sample is extruded from the absorbing element, the sample in the carrier 40 enters the collection cavity 22 through the through hole 44 at the bottom of the carrier 40 and contacts the test strip until the sample collector 30 is completely inserted into the carrier In 40, at this time, the sealing ring 36 on the connecting end 31 of the sample collector 30 is attached to the inner wall of the collection cavity 22 to form a sealing area, which can prevent the liquid sample from the collection cavity 22 when the detection box of the present invention is violently shaken or inverted. Or leak from the carrier 40 . In effect, the absorbent element is in contact with the bottom of the carrier, thereby causing the absorbent element to be compressed, allowing the collected liquid sample, such as a saliva sample, to flow into the bottom of the collection cavity through the through hole 44, a process that requires continuous squeezing of the absorbent element while simultaneously It is necessary to let the sealing ring contact the side wall of the collection cavity and keep it in a sealed state. The detection box uses the cover to cover the collection cavity to keep the sample collector in this state. Therefore, it is necessary to ensure that there is no gap between the cover and the collection cavity. Falls off easily. Using a threaded structure is one way, but it takes a lot of time for the thread to rotate. The structure in the device of the present invention is specifically adopted, which will be described and described in detail below.

Here, the absorbent element is intended to absorb liquid samples, such as saliva, urine, sweat or other samples. The material of the absorbing element can be any water-absorbing material, such as sponge and the like.

Cover and collection chamber

The cover body is used to seal the collection chamber to prevent leakage of samples in the collection chamber, as shown in Figure 3 and Figure 7 . The bottle body 20 is provided with a collection cavity 22, the collection cavity 22 is used for collecting fluid samples, and there is a test element in the collection cavity 22, which is used to test whether there is an analyte in the fluid sample, and the collection cavity 22 includes the upper side of the bottle body 20. The cover body 10 is used to cover the opening of the collection cavity 22. The cover body 10 matches the collection cavity 22. When the collection cavity 22 is square, the cover body 10 is also square. When the cover body 10 covers the opening of the collection cavity 22, the cover body 10 is locked to the outer wall of the opening of the collection cavity 22 through the buckle structure 12, so that the cover body 10 is fixed in the collection cavity 22. superior. In some embodiments, the collection chamber includes a carrier on which a plurality of test elements are disposed. As before, the carrier is located in the collection chamber, and the sample collector with the absorbent element is attached to the lid, so that during the lid closure of the collection chamber, the absorbent element contacts the bottom of the carrier, allowing the absorbent element to be compressed Thereby, the liquid sample is squeezed out, so that the liquid sample flows into the bottom of the collection chamber and contacts the test element at the bottom of the collection chamber. A test element is disposed in the groove of the carrier, and the test element includes a sample application area, a marking area, a detection area and an absorption area. Typically, the sample application area of the test element is located at the bottom of the collection chamber to receive the liquid sample. In this way, a part of the liquid sample flows on the test element by capillary force to complete the test of the analyte.

The outer wall of the collection cavity 22 includes a protruding structure 21 . When the cover body 10 is closed to the opening of the collection cavity 22 , the snap structure 12 is engaged with the protruding structure 21 . The way of snap connection here means that the cover body 10 and the collection chamber 22 cooperate in a manner similar to "insertion" or "piston type", and are combined together in the form of snaps. The way of snap connection is opposite to the way of thread rotation. The way of the thread requires relative rotation, and then the cover body and the collection chamber are combined together.

In some preferred ways, as shown in FIG. 11 , the buckle structure 12 includes a lower buckle surface 13 and an upper buckle surface 14 , and the angle formed by the lower buckle surface 13 and the horizontal plane (angle 2 ) is greater than the upper buckle surface 14 and the horizontal surface. The angle of the angle (angle 1), so the slope of the lower buckle surface 13 is greater than the slope of the upper buckle surface 14. When the cover body 10 and the collection cavity 22 need to be closed, the lower buckle surface 13 has a larger slope. The contact between the surface 13 and the protruding structure 21 makes the process of the cover body 10 and the collection cavity 22 closed relatively easily, and the process is a process of slow elastic deformation, so the required force is small. It is specifically reflected in the feeling of the operator when it is buckled: it can be buckled by gently pushing it. When the cover body 10 and the collection cavity 22 need to be separated, due to the small slope of the upper buckle surface 14, the contact between the upper buckle surface 14 and the raised structure 21 makes the process of separating the cover body 10 and the collection cavity 22 relatively difficult. A process of rapid elastic deformation, which is embodied in the operator's feeling when separating: need to use a large force to separate. There will be more detailed instructions below.

Thus, as shown in FIG. 3, when the cover 10 is provided with a sample collector 30, one end of the sample collector 30 is provided with an element for collecting fluid samples, such as an absorbent element, which is generally textured when dry Hard, but becomes soft when exposed to liquids, such as saliva or urine. During the process of covering the opening of the collection cavity 22 with the cover body 10 with the absorbing element, the sample collector 30 is gradually inserted into the collection cavity 22, the absorbing element contacts the pressing surface (the bottom of the carrier 40), and as the cover body 30 is inserted into the collecting cavity 22 10 continues to be inserted, the cover body 10 and the opening of the collection cavity 22 continue to approach, in the process, the absorbing element is squeezed, the liquid of the absorbing element is released, and the cover body 10 and the opening of the collection cavity 22 continue to approach until the protrusion on the outer wall of the collection cavity 22. The lifting structure 21 is in contact with the lower buckle surface 13 of the buckle structure 12 . As shown in FIG. 7 and FIG. 11 , in the following process, the cover body 10 and the collection cavity 22 are respectively elastically deformed, and the position of the buckle structure 12 on the cover body 10 expands slightly outward. Correspondingly, the collection cavity The position of the raised structure 21 on the 22 is squeezed inward, and the degree of deformation depends on the thickness of the position of the buckle structure 12 of the cover body 10 and the thickness of the position of the raised structure 21 of the bottle body 20. The thicker the thickness, the smaller the degree of deformation and the deformation. Difficulty; the thinner the thickness, the greater the degree of deformation, and the easier it is to deform. In order to facilitate the closure between the cover body 10 and the collection cavity 22, the cover body 10 and the bottle body 22 can be selected from plastics with strong plastic deformation ability. The cover body 10 and the collection cavity 22 continue to undergo elastic deformation until the collection cavity 22 slides over the lower buckle surface 13 and enters the upper buckle surface 14, and the raised structure 21 of the collection cavity 22 contacts the upper buckle surface 14. In the following process , the position of the buckle structure 12 on the cover body 10 shrinks inward, and the position of the raised structure 21 on the collection cavity 22 expands outward until the cover body 10 and the collection cavity 22 both return to the original state, and the cover body is completed. 10 is covered with the collection cavity 22, in this state, the absorbing element is always in a pressed state, it will transmit a force to the cover 10 to separate from the collection cavity 22 through the sample collector 30, wherein the sample collector 30 The inner sealing ring 36 is in contact with the inner wall of the collection cavity 22, which can offset a part of the separation force, but in general, the separation force cannot be completely offset, but due to the small slope of the upper surface 14, the upper surface 14 is separated. The protruding structure 21 requires a large force, so the cover body 10 and the collection cavity 22 cannot be deformed by the separation force generated by the absorbing element alone. On the contrary, the separation force makes the convex structure 21 of the collection cavity 22 deform. The contact with the upper buckle surface 14 is more tense or firm. At this time, the cover body 10 is not easily separated from the opening of the collection cavity 22 , and the cover body 10 will not shake on the collection cavity 22 . In this way, it is ensured that the absorbing element is always in a compressed state, and the liquid sample can be continuously released into the collection chamber 22 . The above elastic deformation is very small, and in the actual use of the test box, the buckling process is very short, and it is difficult to observe with the naked eye, but the matching relationship between them can be felt by the hands when buckling and separating. Embodied, that is, the above: lightly push to clasp, need to use a large force to separate.

In some ways, in order to facilitate the protruding structures 21 on the outer wall of the collection chamber 22 to slide into the cover body 10 for closure, the lower buckle surface 13 can be smooth and has a certain curvature. Correspondingly, the protruding structures 21 are also preferably It has a smooth surface, and the two smooth surfaces are in sliding fit to reduce friction, and the cover body 10 can be matched with the collection cavity 22 with little effort.

In some ways, as shown in FIG. 11 , the protruding structure 21 includes an upper convex surface 70 and a lower convex surface 71 . When the cover body 10 and the collection cavity 22 are in a closed state, the lower convex surface 71 of the protruding structure 21 and the snap structure The upper buckle surface 14 of 12 is kept in close contact. When the upper buckle surface 14 is at a certain angle with the horizontal plane (angle 1), the lower convex surface 71 should also be at a certain angle with the horizontal plane (angle 3), and in order to cover the collection cavity when closed 22 is in close contact with the cover body 10, and the angle of the angle 3 is equal to the angle 1. When the plane where the upper buckle surface 14 is located is perpendicular to the central axis of the cover body 10, the lower convex surface 71 of the corresponding convex structure 21 should also be in line with the central axis of the cover body 10. Vertical, at this time, the lower convex surface 71 of the collection cavity 22 is close to the upper buckle surface 14, and the cover body 10 tightly clamps the collection cavity 22. In this case, to separate the cover body 10 and the collection cavity 22 will become very difficult. In a preferred manner, in the process of capping the cover body 10 and the collection cavity 22, the upper convex surface 70 will contact the lower buckle surface 13 to cause elastic deformation of the cover body 10 and the collection cavity 22, in order to make the capping process easier , the upper convex surface 70 may have a smooth surface, or the plane where the upper convex surface 70 is located may form a certain angle (angle 4) with the horizontal plane. In some ways, the upper buckle surface 14 intersects the lower buckle surface 13 or the extension surface of the upper buckle surface 14 intersects the extension surface of the lower buckle surface 13, and the length of the lower buckle surface 13 is longer than the length of the upper buckle surface 14, In this way, it is easier to slide the raised structures 21 of the collection cavity 22 into the cover body 10, and the cover body 10 will slowly change outward. It is short, and the cover body 10 and the collection cavity 22 have the force of rebound, so the collision between the convex structure 21 and the buckle structure 12 produces a crisp sound, reminding the cover body 10 and the collection cavity 22 that the cover is closed.

In some manners, in order to ensure that the cover body 10 can be more firmly matched or covered with the collection cavity 22 , at least two snap structures 12 are provided in the cover body 10 , or more than three. In some ways, referring to FIGS. 8-9 , the cover body 10 is square as a whole, and four corners of the cover body 10 are provided with snap structures 12 , and the snap structures 12 are at right angles. At the same time, the outer wall of the collection cavity 22 has a box-shaped raised structure 21, and the raised structure 21 is matched with the four snap structures 12, so that when the cover body 10 is closed to the opening of the collection cavity 22, the cover body 10 is more durable. Easy to get out of the collection chamber 22 . The main purpose of this is that when the sample collector 30 has an elastic sealing ring 36, the sample collector 30 is inserted into the collection cavity 22, and the sealing ring 36 cooperates with the inner wall of the collection cavity 22 to form a sealing area, so as to maximize the limit The liquid sample in the collection chamber 22 or in the carrier 40 is prevented from leaking out. Due to the sealing fit between the sealing ring 36 and the inner wall of the collection cavity 22 , it is more desirable that the cover body 10 and the collection cavity 22 cooperate closely in the longitudinal direction to avoid separation of the cover body 10 and the collection cavity 22 . In some other manners, the buckle structure 12 is disposed on the inner wall of the cover body 10 near the bottom, and the buckle structure 12 is in a straight line at this time.

In some ways, as shown in FIGS. 8-9 , the cover body 10 is provided with a limit clip 15 , and the limit clip 15 includes two parts: a first limit part 81 and a second limit part 82 . When the 10 and the collection cavity 22 are in a capped state, the second limiting portion 82 and the buckle structure 12 can respectively limit the protruding structures 21 on the outer wall of the collection cavity 22 from the upper and lower sides, so that the cover body 10 is placed on the bottle body 20. The first limiting part 81 can keep the lid body 10 in contact with the opening of the collecting cavity 22, so that the upper end of the bottle body 20 is embedded in the lid body 10 and cannot be shaken. In some preferred manners, the limiting clips 15 are arranged on the inner wall of the square cover 10 and at the corners.

The above-mentioned capping method of the cover body 10 and the collection cavity 22 and the traditional screw rotation method of the cover body 10 and the collection cavity 22 have the advantages of simple operation, squeezing the absorbing element, and improving the detection efficiency, but relatively speaking, it is difficult to repeat the process. In the second detection process, the method of thread rotation is much more complicated and difficult to operate than the technical solution provided by the present invention. The purpose of the detection box of the present invention is to quickly obtain a preliminary detection result, and "fast" and "convenient" are the primary requirements to be achieved by the detection box of the present invention.

In some ways, as shown in FIG. 8 , since the cover body 10 and the collection cavity 22 are tightly closed, it is inconvenient to separate the cover body 10 and the collection cavity 22 . The part 83 is convenient for the operator to exert force on the cover body 10. The holding part 83 is integrally formed with the cover body 10, which is convenient for processing.

In some ways, the cover body 10 is provided with a hollow connecting portion 80, the hollow connecting portion 80 is used to connect the sample collector 30, and the cross connector 34 can be inserted into the hollow connecting portion 80 by pressing the pressing table 37 with the index finger and the middle finger, The connection between the cover body 10 and the sample collector 30 is completed. When the cover body 10 and the collection cavity 22 are in a closed state, the absorbing element in the sample collector 30 is in a compressed state, and at this time, there will be a The force for separating the collecting cavity 22 is very small because the force generated when the absorbing element is compressed is much smaller than the force required to separate the cover 10 and the collecting cavity 22, so the snap structure 12 and the protruding structure 21 will not be separated.

The above are only specific embodiments of the invention, but the protection scope of the invention is not limited to this. Any changes or replacements that are not thought of without creative work should be covered within the protection scope of the invention. Therefore, the protection of the invention The scope should be subject to the protection scope defined by the claims.

The invention shown and described herein may be practiced in the absence of any element, limitation, specifically disclosed herein. The terms and expressions employed are to be used as terms of description rather than limitation and it is not intended that the use of these terms and expressions exclude any equivalents of the features shown and described, or parts thereof, and it should be recognized that each Both modifications are possible within the scope of the present invention. It should therefore be understood that while the invention has been specifically disclosed by various embodiments and optional features, modifications and variations of the concepts described herein may be employed by those of ordinary skill in the art and are considered to fall within the scope of It is within the scope of the invention as defined in the appended claims.

The contents of articles, patents, patent applications, and all other documents and electronically available information described or recorded herein are hereby incorporated by reference in their entirety to the same extent as if each individual publication was specifically As if indicated separately for reference. Applicants reserve the right to incorporate into this application any and all materials and information from any such articles, patents, patent applications or other documents.

Claims (15)

1. a detection box, characterized in that, the detection box comprises: a fluid sample collection cavity, the collection cavity includes an opening, and a test element is provided in the collection cavity, and the test element is used for testing whether there is an analyte in the fluid sample; Detecting The box also includes a cover for closing the opening of the collection cavity; Wherein, the cover body includes a snap structure for snapping the receiving cavity opening. When the cover body covers the collecting cavity opening, the snap structure snaps to the outer wall of the receiving cavity opening, so that the cover body is fixed on the collecting cavity. 2 . The detection box according to claim 1 , wherein the outer wall of the collection cavity includes a raised structure, and when the cover body is closed to the opening of the collection cavity, the buckle structure is engaged with the raised structure. 3 . 3 . The detection box according to claim 1 , wherein at least two snap structures are provided in the cover body. 4 . 4 . The detection box according to claim 1 , wherein the buckle structure is a right angle or a straight line. 5 . 5 . The detection box according to claim 1 , wherein the cover body is provided with a holding part, the holding part and the cover body are integrally formed, and the lower part of the holding part is hollow. 6 . 6 . The detection box according to claim 1 , wherein the bottom of the collecting cavity protrudes upward. 7 . 7. A detection box according to claim 2, wherein the buckle structure comprises a lower buckle surface and an upper buckle surface, and the angle formed by the lower buckle surface and the horizontal plane is greater than the angle formed by the upper buckle surface and the horizontal plane. angle. 8 . The detection box according to claim 2 , wherein the cover body is provided with a limit clip, the limit clip includes a first limit part and a second limit part, and the first limit part is opposite to the convex. 9 . The starting structure limits the position, and the second limiting structure limits the opening of the collection cavity. 9 . The detection box according to claim 2 , wherein the lower buckle surface is a smooth surface, and the raised structure on the collecting cavity comprises an upper convex surface and a lower convex surface, wherein the upper convex surface contacts the lower buckle surface to guide the lower surface. 10 . The convex surface is in contact with the snap-up surface. 10 . The detection box according to claim 8 , wherein the cover body is square, and the limit clips are arranged on the inner wall of the cover body and at the corners of the cover body. 11 . 11 . The detection box according to claim 10 , wherein the collection cavity is square, and a sampling hole is provided on the side of the collection cavity near the corner. 12 . 12. A detection box according to claim 1, characterized in that, the detection box further comprises a carrier, the carrier has a plurality of card slots for setting test elements, the carrier is located in the collection cavity, and the carrier has a cavity, Meanwhile, the carrier has a bottom, and the bottom of the carrier is provided with through holes. 13 . The detection box according to claim 12 , wherein the cover body is further provided with a sample collector, and the sample collector is used to be inserted into the cavity in the carrier and contact with the bottom of the carrier. 14 . 14 . The detection box according to claim 12 , wherein the sample collector is provided with an annular groove, a sealing ring can be installed in the annular groove, and the sealing ring can be sealed with the collection cavity. 15 . 15 . The detection box according to claim 12 , wherein the bottom of the carrier is provided with a second boss, the second boss is in the shape of a box, the bottom of the collection cavity is provided with a support, and the support is opposite to the second boss. 16 . The four corners of the table are supported.

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