CN103948692B - A kind of livestock and poultry compound medicine containing the radix paeoniae rubrathe and amikacin - Google Patents
A kind of livestock and poultry compound medicine containing the radix paeoniae rubrathe and amikacin Download PDFInfo
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- CN103948692B CN103948692B CN201410202824.7A CN201410202824A CN103948692B CN 103948692 B CN103948692 B CN 103948692B CN 201410202824 A CN201410202824 A CN 201410202824A CN 103948692 B CN103948692 B CN 103948692B
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Abstract
The present invention relates to a kind of livestock and poultry compound medicine containing the radix paeoniae rubrathe and amikacin, be made up of the raw material of following weight portion: amikacin 3 30 parts, the radix paeoniae rubrathe 5 200 parts.Inventor utilizes Lactiflora to form compound medicine with antimicrobial.Research proves, after adding the radix paeoniae rubrathe, it is possible to the reverse bacterial drug resistance to antimicrobial, thus improves the result for the treatment of of antimicrobial in antimicrobial.According to a conventional method this compound medicine is made powder, tablet, oral liquid or granule, add in animal and fowl fodder according to the addition of 0.1 7g main ingredient/kg feed and feed, drug cost and medicament residue can be greatly reduced, create higher economic benefit for raiser, also ensure that food security simultaneously.
Description
Technical field
The invention belongs to livestock and poultry Escherichia coli and salmonella infection treatment technology field, particularly relate to a kind of containing the radix paeoniae rubrathe
Livestock and poultry compound medicine with amikacin.
Background technology
Fowl salmonellosis (Avian salmonellosis) is by one or more salmonellas in Salmonella
The general name of caused poultry disease.Difference according to pathogen antigen structure can be divided into 3 classes: white diarrhea, avian typhoid and fowl are secondary
Typhoid fever.Wherein white diarrhea and avian typhoid salmonella have host specificity, mainly cause chicken and turkey morbidity；And avian paratyphoid is husky
Door Salmonella then can extensively infect many animals and people, is mankind's salmonella infection and food by its poultry polluted and products thereof
One of main source of poisoning.Fowl salmonellosis is commonly formed considerably complicated propagation circulation.Sick fowl and the fowl that carries disease germs are main
The infection sources, can pass through alimentary canal, respiratory tract or eye conjunctiva horizontal transmission, can infect poult, cause big portion after ovum vertical transmission
Dividing death, poultry carries disease germs for a long time, the ovum that then output is carried disease germs, if hatching in this, as kind of an egg, then and the generation can gone round and begun again
In generation, passes on from one to another, and causes fowl salmonellosis to be difficult to purify in chicken group, causes serious economic loss.Owing to salmonella is chicken group
Middle pollution face is big, and is easily generated drug resistance, and immune effect of vaccine in the market is the most undesirable.Therefore, breeder flock quarantine, medicine
Thing controls, environment disinfected purifies, strengthen feeding and management and health and epidemic prevention is still and controls and prevent salmonella from entering food chain
Essential measure.Chick is drunk 0.01% liquor potassic permanganate or other drug 1～carries out chemoprophylaxis in 2 days after going out shell.This bacterium pair
Common drug produces drug resistance, forces and has to carry out various medicine in production and be used alternatingly, in the hope of preferably controlling drug-fast bacteria.
This bacterium produces stronger drug resistance to aminoglycoside medicaments at present, and aminoglycoside inactive enzyme is to these antibacterials molecules
In some protection antibacterial activity necessary to group modify so that it is affinity ribosomal with target site is greatly lowered.
These inactive enzymes include aminoglycoside acyltransferase (AAC), aminoglycoside adenylyl transferase (AAD), aminoglycoside phosphorus
Acid transferase (APH), gland nucleotidyltransferase (ANT) etc..The most it is found that not in the drug-fast bacteria of many aminoglycosides
Inactive enzyme with characteristic.
Escherichia coli are common conditioned pathogens, are also a kind of diseases often sent out, and it primary can cause the acute sepsis of chicken
The multiple location severe infections such as disease, peritonitis, hepatitis, pneumonia, enteritis, also can secondary or mixed send out in virosis, cause to aquaculture
Huge economic loss.Amoxicillin, ampicillin, Ceftiofur, ceftriaxone, amoxicillin/clavulanate, ammonia benzyl west
The beta-lactam nucleus class antibiotic such as woods/Sulbactam are the conventional important drugs preventing and treating this disease, along with the cultivation intensive journey of scale
Degree is more and more big, and medication is more and more spread unchecked, and its antibody-resistant bacterium is the most, and the report about Drug Resistance of E. coli is the most more.
Research confirms, one of main mechanism of resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (Extended-
Spectrum β-lactamase, ESBLs), this enzyme can hydrolyze beta-lactam nucleus more by force and rapidly, makes this kind of antibiotic lose
Antibacterial activity.ESBLs is the main enzyme type of beta-lactamase, and it is not only to cephalo three generations and AZT resistance, and to ammonia
Base glucosides class, quinolones and sulfamido are crossing drug resistant, only to Carbapenems, a mould alkenes medicaments insensitive.Many documents
It has been reported that colibacillary multi-drug resistant with produce ESBLs have substantial connection, both at home and abroad to more pay close attention to.Inventor is
The detection of food animal source pathogenic bacteria ESBLs, extraction, enzyme are closely carried out to the percent hydrolysis of antibiotic and Sulbactam, Tazobactam Sodium
And the research such as the enzyme protection effect that presses down of Chinese medicine, drug sensitive test colibacillary to part ESBLs shows, its multidrug resistant rate is bright
Aobvious higher than non-ESBLs bacterial strain.It addition, result also shows that product ESBLs bacterial strain is not only tight to third generation cephalosporins such as Ceftiofurs
Weight resistance, and also antimicrobial resistance multiple to FQNS, aminoglycoside and sulfamido, phosphonomycin etc., in serious
Multidrug resistant.Inventor is separated to resistance to phosphonomycin in producing ESBLs bacterial strain and produces the Escherichia coli of fosA3 drug resistant gene, more strengthens
The drug resistance of bacterium.
Salmonella and colibacillary drug resistance cause raiser's drug cost to increase, and treatment extends the course for the treatment of, and livestock and poultry are dead
Rate of dying increases, and brings bigger economic loss to production, and increases livestock and poultry medicament residue risk.Therefore, actual production is needed badly
A kind of to regardless of whether the salmonella of resistance and Escherichia coli can have a medicine of preferable therapeutic action, and treatment can be shortened treat
Journey, reduces the death rate, reduces economic loss and reduces medicament residue, creating higher economic benefit for raiser, also ensure people
Class healthy and safe.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of livestock and poultry compound medicine containing the radix paeoniae rubrathe and amikacin, it
Bacterium can be killed quickly, overcome weak curative effect that antimicrobial treatment causes due to drug resistance problems, consumption is big, residual is high and becomes
This high defect, it is to avoid simple Chinese medicine sterilizing spectrum is narrow, be sterilized slow problem.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing the radix paeoniae rubrathe with the poultry of amikacin
Fowl compound medicine, is made up of the raw material of following weight portion: amikacin 3-30 part, radix paeoniae rubrathe 5-200 part.
Described compound medicine is prepared as powder, tablet, oral liquid or granule.
The preparation method of described compound medicine is: the radix paeoniae rubrathe pulverized 60 mesh sieves, then mixes with the antimicrobial of powder,
It is prepared as powder, tablet, oral liquid or granule according to a conventional method.
The drug resistance problems existed for current livestock and poultry Escherichia coli and salmonella infection, inventor utilizes the radix paeoniae rubrathe with anti-
Bacterium medicine composition compound medicine.Research proves, after antimicrobial adds the radix paeoniae rubrathe, it is possible to the reverse bacterial drug resistance to antimicrobial, from
And improve the result for the treatment of of antimicrobial.According to a conventional method this compound medicine is made powder, tablet, oral liquid or granule, press
Add in animal and fowl fodder according to the addition of 0.1-7g main ingredient/kg feed and feed, drug cost and medicine can be greatly reduced
Residual, creates higher economic benefit for raiser, also ensure that food security simultaneously.
Detailed description of the invention
One, the radix paeoniae rubrathe drug resistance inversion Effect study to antimicrobial
Antimicrobial itself has treatment Escherichia coli and the effect of salmonella, but owing to producing the Escherichia coli of drug resistant gene
With salmonella, there is stronger drug resistance, cause antimicrobial not show in the case of normal dosage and preferably control
Therapeutic effect.
1, to the suppression test of colibacillary resistance after the radix paeoniae rubrathe mixes with antimicrobial
96 orifice plates use microtest tube doubling dilution, first determines antimicrobial to producing ESBLs and fosA3 resistance base
Minimal inhibitory concentration and the radix paeoniae rubrathe of the e. coli strains of cause are antibacterial to the Asia producing ESBLs and fosA3 drug resistant gene e. coli strains
Concentration, add the most in the medium the radix paeoniae rubrathe of subinhibitory concentration reuse microtest tube doubling dilution cultivate measure antibacterial
The minimal inhibitory concentration of medicine；Utilize continuous passage method added with the same subinhibitory concentration radix paeoniae rubrathe and the cultivation of same concentration antimicrobial
Base carries out Secondary Culture, until the antimicrobial minimum observed is antibacterial to product ESBLs and fosA3 drug resistant gene e. coli strains
Concentration with pass on before compared with diminish more than 4 times, can be judged as that the radix paeoniae rubrathe has drug resistance inversion effect to antibacterial medical instrument.Result of the test is united
Meter is as shown in table 1:
Table 1 subinhibitory concentration (0.5g/mL) radix paeoniae rubrathe passes on and causes the change producing ESBLs and fosA3 Escherichia coli Western medicine MIC
(μg/mL)。
As seen from the above table, antimicrobial all reduces more than 4 times to the minimal inhibitory concentration of antibiotic-resistance E. coli, i.e. can determine whether be
The radix paeoniae rubrathe has drug resistance inversion effect to producing ESBLs and fosA3 drug resistant gene Escherichia coli.
2, after the radix paeoniae rubrathe mixes with antimicrobial, the resistance to salmonella suppresses test
96 orifice plates use microtest tube doubling dilution, first determines the antimicrobial minimum to resistance salmonella strain
Mlc and the radix paeoniae rubrathe subinhibitory concentration to resistance salmonella strain, add the radix paeoniae rubrathe of subinhibitory concentration the most in the medium
Reuse microtest tube doubling dilution and cultivate the minimal inhibitory concentration measuring antimicrobial；Utilize continuous passage method added with same
The culture medium of the sample subinhibitory concentration radix paeoniae rubrathe and same concentration antimicrobial carries out Secondary Culture to salmonella persister, until seeing
The antimicrobial minimal inhibitory concentration measured with pass on before compared with diminish more than 4 times, can be judged as that antibacterial medical instrument is had resistance to by the radix paeoniae rubrathe
Medicine reverse effect.Result of the test statistics is as shown in table 2:
Table 2 subinhibitory concentration (0.5g/mL) radix paeoniae rubrathe passes on the change (μ g/mL) causing resistance salmonella Western medicine MIC.
As seen from the above table, antimicrobial all reduces more than 4 times to the minimal inhibitory concentration of resistance salmonella, i.e. can determine whether be
The radix paeoniae rubrathe has drug resistance inversion effect to resistance salmonella.
Two, the application example of compound medicine of the present invention
Embodiment 1-embodiment 10 is prepared: after the radix paeoniae rubrathe was pulverized 60 mesh sieves, as base according to table 3 formula and following methods
Plinth raw material, then mix, according to a conventional method, by compound medicine system during ratio puts into blender by weight with the antimicrobial of powder
Standby one-tenth formulation products.
The formula of table 3 embodiment 1-10 and preparation formulation
| Numbering | Antimicrobial | The radix paeoniae rubrathe | Formulation |
| Embodiment 1 | Amikacin 20g | 80g | Powder |
| Embodiment 2 | Amikacin 13g | 10g | Tablet |
| Embodiment 3 | Amikacin 7g | 160g | Oral liquid |
| Embodiment 4 | Amikacin 30g | 110g | Granule |
| Embodiment 5 | Amikacin 15g | 120g | Powder |
| Embodiment 6 | Amikacin 25g | 50g | Tablet |
| Embodiment 7 | Amikacin 10g | 80g | Oral liquid |
| Embodiment 8 | Amikacin 30g | 160g | Granule |
| Embodiment 9 | Amikacin 3g | 5g | Powder |
| Embodiment 10 | Amikacin 30g | 200g | Tablet |
Above-described embodiment is obtained compound medicine product and has carried out following experiment by inventor:
1, the compound medicine product of the embodiment 1-4 gained efficacy experiment to the grice diarrhoea of 42 ages in days
Clinical symptoms: pig farm, Hengxian County, 42 age in days piglets, this swinery, after wean is turn-taked, starts diarrhoea occur, draws
Watery stools, ight soil contains indigested feed, pig material feeding but be exactly the longest, the most serious diarrhea of pigs dehydration death, do not have
Symptoms of emesis occur, raiser uses multi-medicament, treatment ideal effect the most do not occur.
Cut open inspection pathology: after cuing open inspection, chitling wall is belittled, especially small intestine rear end and colon site, and intestinal mucosa comes off, intestinal wall hyperemia,
Hemorrhage.
Laboratory diagnosis: take pathologic liver dye sheet, Gram's staining, basis of microscopic observation, it is seen that red gram-negative
Property bacillus；Tentatively it is judged as bacillus coli.Being cultivated by Escherichia coli, biochemical test differentiates, it is judged that Infection in Piglets is big
Enterobacteria disease, PCR expands, it was demonstrated that produce ESBLs drug resistant gene and the fosA3 drug resistant gene having CTX-M type.
Test therapeutic regimen: morbidity swinery divides 6 groups of administrations, first group by embodiment 1 according to the addition of 1.5g/kg feed
Be administered, second group with embodiment 2 according to 0.5g/kg feed addition be administered, the 3rd group by embodiment 3 according to 7g/kg feed
Addition be administered, the 4th group with embodiment 4 according to 1.3g/kg feed addition be administered；Use amikacin pulvis for 5th group
Being administered according to the addition of 0.3g/kg feed, the 6th group is administered according to the addition of 7g/kg feed with the thick powder of the radix paeoniae rubrathe；Above
Six groups of therapeutic regimens the most persistently use 5 days.
Using effect is fed back: after first group to the 4th group medication 2 days, swinery no longer draws watery stools, formed stools, ight soil
In no longer contain feed, be continuing with 3 days, swinery fully recover；After 5th group of medication 2 days, swinery is the most unhealthy, is continuing with 3 days,
Substantially get well, but still draw individually pasty state ight soil, but after drug withdrawal 3 days, recurrence occurs in swinery；After 6th group of medication 2 days, pig
Group, without remarkable improvement, is continuing with 3 days, and swinery continues to have loose bowels, and remaining the most also ratio is more serious.Visible, containing the compound of the radix paeoniae rubrathe
Medicine is better than folk prescription amikacin and the folk prescription radix paeoniae rubrathe to swinery curative effect.
2, the efficacy experiment that the meat duck of 35 ages in days is suffered from diarrhoea by the compound medicine product of embodiment 5-10 gained
Clinical symptoms: Guiping, Guangxi duck field, 35 age in days meat ducks, duck group draws watery stools, has and significantly do not disappear in ight soil
The feed changed.Indivedual serious ducks of suffering from diarrhoea gradually occur that pin is soft slowly dead.
Cuing open inspection pathology: the duck that dies of illness dehydration ratio is more serious, indivedual ducks are the biggest, duck hepatomegaly, hyperemia, the liver of part duck
Having white films on dirty, air bag is muddy, and tentative diagnosis is Escherichia coli or duck oromeningitis.
Test therapeutic regimen: morbidity duck group divides 8 groups of administrations, first group by embodiment 5 according to the addition of 2.5g/kg feed
Being administered, second group is administered according to the addition of 0.9g/kg feed by embodiment 6, raises according to 2.5g/kg by embodiment 7 for the 3rd group
The addition of material is administered, and the 4th group is administered according to the addition of 1.7g/kg feed by embodiment 8；5th group with embodiment 9 according to
The addition of 0.8g/kg feed is administered, and the 6th group is administered according to the addition of 2.3g/kg feed by embodiment 10；7th group of use
Amikacin pulvis is administered according to the addition of 0.3g/kg feed, the 8th group with the thick powder of the radix paeoniae rubrathe according to the interpolation of 4g/kg feed
Amount is administered；Above eight groups of therapeutic regimens the most persistently use 5 days.
Using effect is fed back: after first group to the 6th group medication 3 days, and sick duck no longer draws watery stools, formed stools, no longer
Dead duck occur, be continuing with 2 days, duck group be almost recovered；After 7th group of medication 3 days, duck group's DeGrain, the most still draws water
Sample ight soil, containing indigested feed, is continuing with 2 days, somewhat takes a turn for the better, but the best thorough, and dilute watery stools is still
Occurring, using the compound medicine of embodiment 5 gained instead, be continuing with 3 days, ight soil all transfers to normally；After 8th group of medication 3 days,
Duck does not has the biggest remarkable improvement, is continuing with 2 days, and the duck phenomena of mortality are still without being effectively controlled.Visible, containing the radix paeoniae rubrathe
The curative effect that duck is suffered from diarrhoea by compound medicine is better than folk prescription.
3, the embodiment 5-8 gained compound medicine product efficacy experiment to Salmonella gallinarum disease
Clinical symptoms: Nandan County, Guangxi chicken house, 15 Day-old Broiler Chickens, there is diarrhea, row's white, pasty state loose stool, anus in chicken group
Tomentum fecal pollution around, has lime sample lump, the shriek sending misery having, and has the phenomena of mortality.Cut open the indivedual chickens of inspection
Hepatomegaly be kermesinus to darkviolet, or slightly khaki, matter is crisp fragile, and surface is dispersed in or gathers greyish white, the downright bad point of lark,
Sometimes it is red blutpunkte, typical salmonella genius morbi.
Laboratory diagnosis: take pathologic liver dye sheet, Gram's staining, basis of microscopic observation, it is seen that red gram-negative
Property bacillus；Tentatively it is judged as salmonella disease.Being cultivated by salmonella, biochemical test differentiates, it is judged that chicken infects for sand
Door Salmonella disease, drug sensitive test result is judged as persister salmonella according to NCCLS standard.
Test therapeutic regimen: morbidity chicken group is divided into 6 groups of administrations, first group with embodiment 5 adding according to 2.5g/kg feed
Dosage be administered, second group with embodiment 6 according to 0.9g/kg feed addition be administered, the 3rd group by embodiment 7 according to 2.5g/
The addition of kg feed is administered, and the 4th group is administered according to the addition of 1.7g/kg feed by embodiment 8；Use A meter Ka for 5th group
Star pulvis is administered according to the addition of 0.3g/kg feed, gives according to the addition of 4g/kg feed with the thick powder of the radix paeoniae rubrathe for the 6th group
Medicine；Above six groups of therapeutic regimens the most persistently use 5 days.
Staining effect: after chicken group's medication of first group to the 4th group, sick chicken feed intake rises, and dead chicken no longer occurs, continues
Using 3 days, chicken group be almost recovered；After chicken group's medication of the 5th group 2 days, chicken group's majority is the most unhealthy, still has indivedual chicken death, continues
Continuous use 3 days, chicken death phenomenon is still without being effectively controlled；After chicken group's medication of the 6th group 2 days, the not biggest bright of chicken group
Aobvious change, is continuing with 3 days, and chicken death phenomenon is still without being effectively controlled.Visible, the compound medicine curative effect containing the radix paeoniae rubrathe is excellent
In folk prescription.
Claims (2)
1. the radix paeoniae rubrathe and amikacin are combined in preparation in terms for the treatment of livestock and poultry salmonella and coli-infection disease preparation
Application, it is characterised in that in described preparation, the weight ratio of the radix paeoniae rubrathe and amikacin is: amikacin 3-30 part, red
Chinese herbaceous peony 5-200 part.
Application the most according to claim 1, it is characterised in that described preparation is powder, tablet, oral liquid or particle
Agent.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176944A (en) * | 2016-08-22 | 2016-12-07 | 广西大学 | A kind of poultry compound medicine containing Cortex Cinnamomi and amikacin |
| CN106176896A (en) * | 2016-08-22 | 2016-12-07 | 广西大学 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and amikacin |
| CN106420893A (en) * | 2016-08-29 | 2017-02-22 | 广西大学 | Tadehagi triquetrum and amikacin containing compound medicine for livestock and poultry |
| CN106265919A (en) * | 2016-09-21 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Radix Glycyrrhizae, Cortex Cinnamomi and amikacin |
| CN106389487A (en) * | 2016-11-24 | 2017-02-15 | 防城港市畜牧站 | Compound pharmaceutical composition used for poultry and capable of lowering medicine side effect |
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Denomination of invention: A compound medicine for livestock and poultry containing radix paeoniae rubra and amikacin Effective date of registration: 20210111 Granted publication date: 20160907 Pledgee: Guangxi Beibu Gulf Bank Limited by Share Ltd. small business financial services center Pledgor: GUANGXI NANNING TAOYUAN VETERINARY DRUG FACTORY Registration number: Y2021450000002 |
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