CN103843770A - Bactericidal composition containing fluopyram and fludioxonil - Google Patents
Bactericidal composition containing fluopyram and fludioxonil Download PDFInfo
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- CN103843770A CN103843770A CN201210519164.6A CN201210519164A CN103843770A CN 103843770 A CN103843770 A CN 103843770A CN 201210519164 A CN201210519164 A CN 201210519164A CN 103843770 A CN103843770 A CN 103843770A
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- bactericidal composition
- fludioxonil
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- acid amides
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Abstract
The invention relates to a bactericidal composition containing fluopyram and fludioxonil. The bactericidal composition comprises the effective components including the fluopyram and the fludioxonil, wherein the mass ration of the two effective components is (1-15): (15-1), the total mass percent of the effective components in the bactericidal composition is 1-90%, preferentially, the total mass percent of the effective components in the bactericidal composition is 20-60%, the bactericidal composition also comprises the balance of auxiliary components which are allowed to be used and acceptable in the aspect of pesticide, and the bactericidal composition can be prepared into missible oil, wettable powder, water dispersible granules and suspending agent by the known method. The fluopyram and the fludioxonil are taken as the effective components and are compounded according to a certain proportion, so that the bactericidal composition has obvious synergism for controlling powdery mildew and downy mildew of crops such as vegetables, fruit trees, etc.
Description
Technical field
The present invention relates to a kind of composition pesticide, is a kind of bactericidal composition that contains fluorine pyrrole bacterium acid amides and fludioxonil specifically.
Background technology
Fluorine pyrrole bacterium acid amides, English common name fluopyram, chemical name is the chloro-5-(trifluoromethyl of N-{2-[3-)-2-pyridine radicals] ethyl-
-tri-fluoro-O-toluamides }, be a kind of new benzamides series bactericidal agent, suppress mitochondrial respiratory by the electronics transfer that hinders succinate dehydrogenase in respiratory chain.Be mainly used in preventing and treating on broad leaf crop the microbial disease of capsule.To the downy mildew on the vegetables such as cucumber, custard squash, powdery mildew, the downy mildew of fruit tree etc. causes that by germ multiple diseases has favorable effect.Its chemical structural formula is:
。
Fludioxonil belongs to the wide-spectrum bactericide of non-internal-absorting, structure novel, and by suppressing the relevant transfer of glucose phosphorylated, and the mycelial growth of Antifungi, finally cause germ death.Mechanism of action uniqueness, with existing biocide agent without cross resistance.Be mainly used in the rotten Fusariumsp of control snow, wheat net bunt bacterium, rhizoctonia solani etc., gray mold is had to special efficacy.Fludioxonil chemistry 4-by name (2,2-bis-fluoro-1,3-benzo dioxole-4-yl)-1-hydrogen-pyrroles-3-nitrile, its chemical structural formula is
Due to the single systemic fungicide of long-term single use similar medicament, particularly action site, make germ show more and more higher resistance to some conventional medicaments, drug effect decline, in production in the urgent need to preventing and treating the pharmaceutical preparations of downy mildew.According to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can expand fungicidal spectrum, improves germicidal efficiency.Fluorine pyrrole bacterium acid amides is different from the fludioxonil mechanism of action, and mutually composite have good synergistic effect within the specific limits, and composite about fluorine pyrrole bacterium acid amides and fludioxonil, there is not yet at present relevant report at home and abroad.
Summary of the invention
Object of the present invention, be to solve existing fluorine pyrrole bacterium acid amides agricultural chemicals and fludioxonil agricultural chemicals is single to disease treating and preventing effects such as crops downy mildew and powdery mildews, the lasting period is short etc. deficiency, provide a kind of synergistic effect significantly, Oomycete disease that can high-efficiency prevention and control various crop novel pesticide that delaying drug resistance produces-carry out taking fluorine pyrrole bacterium acid amides and fludioxonil as the active ingredient bactericidal composition of rational mixture.
Bactericidal composition of the present invention is achieved in the following ways: active ingredient fluorine pyrrole bacterium acid amides (A) is 1～15:15～1 with the mass ratio of fludioxonil (B).
The formulation that described bactericidal composition of the present invention can be prepared according to the known method of those skilled in the art of the present technique is missible oil, wetting powder, water-dispersible granules and suspending agent.
Described bactericidal composition active ingredient fluorine pyrrole bacterium acid amides of the present invention and the gross mass content of fludioxonil in preparation are 1%～90%, are preferably 20%～60%.All the other are in agricultural chemicals, to allow to use and acceptable auxiliary element.
The auxiliary agent (auxiliary element) using in described bactericidal composition of the present invention comprises wetting agent, dispersant, antifreezing agent, thickener, defoamer, disintegrant, filler etc., and other is of value to the known substance of active ingredient stable and drug effect performance in preparation-be all conventional in pesticidal preparations or allows the various compositions that use, concrete composition and consumption, according to formula requirement, determine by routine test.
Described wetting agent is selected from: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., one or more in wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Described antifreezing agent is selected from: one or more in ethylene glycol, propane diols, glycerine.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more in aliphatic alcohols compound.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium bicarbonate.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
The present invention has significant synergies taking fluorine pyrrole bacterium acid amides and fludioxonil as the composite bactericidal composition of active ingredient, Oomycete disease that can high-efficiency prevention and control various crop, and delaying drug resistance produces.Fungicidal composition of the present invention can be used for preventing and treating the multiple diseases of the crop such as vegetables, fruit tree, especially cucumber downy mildew, powdery mildew, Pumpkin powdery mildew, downy mildew of garpe, tomato downy mildew, tomato late blight, capsicum epidemic disease etc.
embodiment:
In order to make object of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to absolutely not these examples.The method that the present invention adopts indoor bioassay and field trial to combine.If no special instructions, the ratio (comprising percentage) of below mentioning is all mass ratio.
The synergy test of fluorine pyrrole bacterium acid amides and iprodione.It is tested object that test adopts powdery mildew of cucumber bacterium.
Concrete grammar is:
(1) test medicine
The former medicine of 96% fluorine pyrrole bacterium acid amides, is produced by Jiangsu Heyi Chemical Industry Co., Ltd.; The former medicine of 96% fludioxonil, Jiangsu Changlong Chemical Co produces.
(2) experimental subjects
Do not execute from Shouguang, Shandong fluopicolide and fludioxonil and similar medicament cucumber cultivation gather and separate, for examination cucumber variety: Chang Chun Mi Ci.
(3) test method and Tests of Synergistic Actions
1. the liquid of single dose toxicity test preparation
96% fluorine pyrrole bacterium acid amides and the former medicinal acetone of fludioxonil are dissolution with solvents, are made into 10000 μ g/ml mother liquors, in 4 DEG C of preservations, stand-by.
2. test plant
Susceptible cucumber variety Chang Chun Mi Ci is cultivated in pot for growing seedlings, be placed in greenhouse and cultivate, plant grows to three to four leaf after dates, gathers the blade of identical leaf age, for cultivation and the mensuration of powdery mildew of cucumber bacterium.
3. the cultivation of powdery mildew of cucumber bacterium and the preparation of spore suspension
Powdery mildew of cucumber bacterium adopts plants method to cultivate under 20 DEG C, the condition of 12h alternation of light and darkness, and every 30d turns culture 1 time.When inoculation, with the conidium on sterile water wash-out incidence of leaf, being mixed with spore concentration is l × 10
6the suspension of individual/mL.
4. strains tested sensitivity testing
Adopt leaf dish moisturizing method to carry out toxicity test.First the blade of collection is prepared into the leaf dish that diameter is 1.5cm, mix at random, be placed in respectively the series concentration liquid configuring and soak lh, 50 leaf dishes of each concentration, test is with the blank that is treated to of adding medicine not, after immersion finishes, leaf faces up and puts on the wetting blotting paper of identical liquor strength, liquid on leaf dish is blotted, the spore suspension l0L preparing is inoculated in to leaf dish central authorities, and room temperature is placed after 5min, is placed under 20 DEG C, the condition of 12h alternation of light and darkness and cultivates, after 10d, measure the onset area on leaf dish, calculate EC
50.
On the basis of preliminary experiment, respectively single dose fluorine pyrrole bacterium acid amides and fludioxonil are carried out to toxicity test in order to upper method, the two EC
50value is respectively 1.1 ㎎/l and 12.8 ㎎/l.
The percentage that accounts for leaf disc area according to lesion area is divided sick level:
0 grade: scab
1 grade: lesion area accounts for 1% ~ 20% of leaf disc area
2 grades: lesion area accounts for 21% ~ 50% of leaf disc area
3 grades: lesion area accounts for the more than 50% of leaf disc area
5. mixture combination arranges
60% fluorine pyrrole bacterium acid amides fludioxonil mass ratio is respectively 5%+55%, 6%+54%, 10%+50%, 15%+45% and 30%+30% totally 5 mixture combinations.
6. mixture toxicity test and interpretation of result
Carry out the toxicity test of mixture according to mixed ratio by single dose toxicity test method.
According to the abundant method of Sun Yun by the EC of each processing measuring
50value is converted into actual mixed toxicity index (ATI); According to the proportioning of mixture, obtain theoretical mixed toxicity index (TTI), calculate the co-toxicity coefficient (CTC) of mixture by following formula.
Single dose toxicity index=(standard medicament EC
50/ reagent agent EC
50) * 100
ATI=(standard medicament EC
50/ reagent agent (using with) EC
50) * 100
The content (%) of the toxicity index X B of content (the %)+B of the toxicity index X A of TI I=A in mixed in mixed
CTC?=（ATI?/?TTI?）*1?0?0
If co-toxicity coefficient is large 120, showing has synergistic effect; If be starkly lower than 100 (below 80), be indicated as antagonism; Between 100～120, be indicated as summation action data in table 2
The different proportioning fluorine of table 1 pyrrole bacterium acid amides and virulence and the synergistic effect of fludioxonil mixture to powdery mildew of cucumber bacterium
| Pharmacy quality ratio | Virulence regression equation | Phase relation numerical value | EC50(mg/L) |
| Fluorine pyrrole bacterium acid amides (A) | Y=0.7442X+4.9692 | 0.9898 | 1.1 |
| Fludioxonil (B) | Y=1.2038X+3.6671 | 0.9776 | 12.8 |
| 1:11 | Y=1.1543X+3.9149 | 0.9632 | 8.71 |
| 1:9 | Y=1.1321X+3.9230 | 0.9668 | 8.94 |
| 1:5 | Y=1.1129X+4.0707 | 0.9441 | 6.84 |
| 1:3 | Y=1.1056X+4.1876 | 0.9774 | 5.43 |
| 1:1 | Y=1.0981X+4.4206 | 0.9325 | 3.37 |
The composite co-toxicity to powdery mildew of cucumber bacterium of table 2 fluorine pyrrole bacterium acid amides and fludioxonil
| Test medicine | Mass ratio | Actual measurement poison refers to | Theoretical poison refers to | Co-toxicity coefficient | Conclusion |
| Fluorine pyrrole bacterium acid amides (A) | 1:0 | 100.00 | 100.00 | / | / |
| Fludioxonil (B) | 0:1 | 8.59 | 8.59 | / | / |
| A+B | 1:11 | 12.63 | 9.73 | 129.8 | ? |
| A+B | 1:9 | 12.30 | 10.64 | 115.6 | ? |
| A+B | 1:5 | 16.08 | 14.30 | 112.5 | ? |
| A+B | 1:3 | 20.24 | 18.87 | 107.3 | ? |
| A+B | 1:1 | 32.61 | 32.58 | 100.1 | ? |
According to bactericide joint toxicity measuring result, co-toxicity coefficient when fluorine pyrrole bacterium acid amides fludioxonil mass ratio is 1:11 is 129.8, is greater than 120, shows as synergistic effect, and other show as summation action, and while thinking 1:11, synergistic effect is best.Suggestion is carried out further field control effectiveness test to the mixture preparation of suitable proportion 1:11 left and right scope, to evaluate its field practical application effect.
Test example 1: the control efficiency of field trial to powdery mildew of cucumber
(1) pilot survey method
The cucumber ground that is experimental field located at Li Tai township, Yangling district of Shaanxi Province, 4 points are investigated in every community, and every some investigation 2 strains, record occurring degree by staging, and grade scale is as follows:
0 grade: without scab;
1 grade: lesion area accounts for below 5 % of whole leaf area;
3 grades: lesion area accounts for whole leaf area 6 % ~ 10%;
5 grades: lesion area accounts for 11 % ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for the more than 50% of whole leaf area.
(2) control time and number of times
Test is investigated 4 times altogether, i.e. disease index investigation before medicine, preventive effect investigation in 7 days after the 1st medicine, 7 days and preventive effect investigation in 15 days after 2 medicines.
(3) drug effect computational methods
The total number of sheets × 100 of sick leaf rate (%)=sick number of sheets/investigate
Disease index=∑ (the sick number of sheets × relative level numerical value at different levels)/(investigating the total number of sheets × 9) × 100
Control efficiency (%)=(disease index after the front disease index × treatment region medicine of 1-(blank district medicine)/(the front disease index of disease index × treatment region medicine after blank district medicine)) × 100
(4) poisoning investigation method
After dispenser, whether 7d range estimation medicament has poisoning to crop continuously.
(5) result of the test and analysis
The each effect of preventing and treating powdery mildew of cucumber of processing of table 3
As shown in Table 3, fluorine pyrrole bacterium acid amides fludioxonil effect for powdery mildew of cucumber under the proportioning of 1:11 is very remarkable.Complex preparation has significant synergistic effect, and not only quick-acting is remarkable, and its lasting effect is also very outstanding.Under same every mu of 10 milliliters of consumptions, the effect of complex preparation is significantly better than two kinds of single doses, and the effect of high concentration is better than the effect of low concentration.So this complex preparation is worthy to be popularized and applies.
Test example 2: field trial is measured the control efficiency to Pumpkin powdery mildew
(1) investigation method
Experimental field be located in the custard squash booth in Li Tai township, Yangling district of Shaanxi Province, 4 points are investigated in every community, and every some investigation 2 strains, record occurring degree by staging, and grade scale is as follows:
0 grade: without scab;
1 grade: lesion area accounts for below 5 % of whole leaf area;
3 grades: lesion area accounts for whole leaf area 6 % ~ 10%;
5 grades: lesion area accounts for 11 % ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for the more than 50% of whole leaf area.
(2) control time and number of times
Test is investigated 4 times altogether, i.e. disease index investigation before medicine, preventive effect investigation in 7 days after the 1st medicine, 7 days and preventive effect investigation in 14 days after 2 medicines.
(3) drug effect computational methods
The total number of sheets × 100 of diseased plant leaf (%)=sick number of sheets/investigate
Disease index=∑ (the sick number of sheets × relative level numerical value at different levels)/(investigating the total number of sheets × 9) × 100
Control efficiency (%)=(disease index after the front disease index × treatment region medicine of 1-(blank district medicine)/(the front disease index of disease index × treatment region medicine after blank district medicine)) × 100
(4) poisoning investigation method
After dispenser, whether 7d range estimation medicament has poisoning to crop continuously.
(5) result of the test and analysis
The each effect of processing control Pumpkin powdery mildew of table 4
As shown in Table 4, the effect of the mixture of fluorine pyrrole bacterium acid amides fludioxonil 1:11 combination control Pumpkin powdery mildew is very remarkable.Under the consumption of same 10 milliliters every mu, the effect of complex preparation is significantly better than two kinds of single doses, and its quick-acting and lasting effect are all relatively good, especially outstanding with lasting effect.Complex preparation control efficiency under the consumption of high concentration is significantly better than the effect under low concentration consumption.After the 1st, 2 medicines the control efficiency of 7 days reach respectively 68.86% and 78.16%, the 2 medicine after the lasting effect of 15 days more remarkable, reach 84.31%.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to custard squash does not all appear in each treatment agent, illustrates that it is safe to custard squash.
In sum, fluorine pyrrole bacterium acid amides fludioxonil, reasonably having significant control efficiency for Curcurbitaceae Powdery Mildew under proportioning, is given prominence to as good with its instant effect, lasting effect, is the medicament of desirable control Powdery Mildew.By composite, not only significantly improve drug effect, expanded fungicidal spectrum simultaneously, delay the drug-fast generation of germ.So the popularization of this complex preparation is of great significance agricultural production tool.
Claims (4)
1. a pesticide sterilizing composite, is characterized in that: carry out mixture taking fluorine pyrrole bacterium acid amides (A) and fludioxonil (B) as active ingredient; The mass ratio of effective constituents A and B is 1～15:15～1.
2. bactericidal composition according to claim 1, is characterized in that: effective constituents A and the B gross mass percentage composition in preparation is 1%-90%.
3. bactericidal composition according to claim 1, is characterized in that: effective constituents A and the B gross mass percentage composition in preparation is preferably 20%-60%.
4. bactericidal composition according to claim 1, is characterized in that: the formulation that bactericidal composition of the present invention can be prepared according to the known method of those skilled in the art of the present technique is missible oil, wetting powder, water-dispersible granules and suspending agent.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105432651A (en) * | 2015-11-20 | 2016-03-30 | 广东中迅农科股份有限公司 | Suspended seed coating containing fluopyram, fludioxonil and thiamethoxam |
| CN108576008A (en) * | 2018-05-23 | 2018-09-28 | 深圳诺普信农化股份有限公司 | Bactericidal composition and its application |
| CN113057172A (en) * | 2021-02-22 | 2021-07-02 | 安徽润农腾辉生物科技有限公司 | Ternary compound seed dressing agent containing prothioconazole and fludioxonil |
| CN114568440A (en) * | 2022-04-07 | 2022-06-03 | 山东亿嘉农化有限公司 | Bactericidal composition containing fluopyram and fludioxonil and application thereof |
| WO2025031086A1 (en) * | 2024-04-08 | 2025-02-13 | 河北化工医药职业技术学院 | Fludioxonil-containing bactericide and preparation method therefor |
-
2012
- 2012-12-07 CN CN201210519164.6A patent/CN103843770A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105432651A (en) * | 2015-11-20 | 2016-03-30 | 广东中迅农科股份有限公司 | Suspended seed coating containing fluopyram, fludioxonil and thiamethoxam |
| CN108576008A (en) * | 2018-05-23 | 2018-09-28 | 深圳诺普信农化股份有限公司 | Bactericidal composition and its application |
| CN113057172A (en) * | 2021-02-22 | 2021-07-02 | 安徽润农腾辉生物科技有限公司 | Ternary compound seed dressing agent containing prothioconazole and fludioxonil |
| CN114568440A (en) * | 2022-04-07 | 2022-06-03 | 山东亿嘉农化有限公司 | Bactericidal composition containing fluopyram and fludioxonil and application thereof |
| CN114568440B (en) * | 2022-04-07 | 2023-08-25 | 山东亿嘉农化有限公司 | Sterilization composition containing fluopyram and fludioxonil and application thereof |
| WO2025031086A1 (en) * | 2024-04-08 | 2025-02-13 | 河北化工医药职业技术学院 | Fludioxonil-containing bactericide and preparation method therefor |
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Application publication date: 20140611 |