CN103720956A - Traditional Chinese medicine composition for treating hypertension and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hypertension and preparation method thereof Download PDFInfo
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- CN103720956A CN103720956A CN201310753334.1A CN201310753334A CN103720956A CN 103720956 A CN103720956 A CN 103720956A CN 201310753334 A CN201310753334 A CN 201310753334A CN 103720956 A CN103720956 A CN 103720956A
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Abstract
The invention aims at disclosing a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition is mainly prepared from the following raw medicinal materials in parts by weight: 10-30 parts of white peony root, 5-25 parts of semen cassia, 5-10 parts of prepared rehmannia root, 5-10 parts of herba epimedii, 3-6 parts of lucid ganoderma, 1-2 parts of lotus plumule, 2-8 parts of uncaria, 2-8 parts of lycium barbarum leaves, 2-8 parts of raw atractylodes, 1-5 parts of rhizoma acori graminei and 1-5 parts of prepared radix licorice. According to the traditional Chinese medicine composition, common auxiliary materials can be added, and the raw medicinal materials can be prepared into clinically acceptable tablets, granules, pills, capsules, slow release formulation, oral liquid and the like according the conventional technology.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, specifically, relate to one and treat hypertensive pharmaceutical composition and preparation method thereof.
Background technology
Along with people's living standard improves constantly, there is larger variation in dietary structure, the generation of China's heart, cerebrovascular disease and death toll be also in continuous rising, and the ratio that wherein death toll accounts for China's general mortality rate has reached 40% left and right even, and hypertension has become a problem that allows people worry.
Hypertension is a kind of commonly encountered diseases and frequently-occurring disease.This sick general onset is slow, patient is often asymptomatic in early days, or only there are symptoms such as dizziness, headache, cardiopalmus, tinnitus, independently disease of one outwardly, malpractice is actually an important risk factor that causes the heart, cerebrovascular and nephropathy, if will pathological changes become these common hypertension complications such as more serious apoplexy, myocardial infarction and renal failure.
1998, China's cerebrovascular occupied the second of urbanite's cause of death, in rural area, ranks first.The annual death in the whole nation exceedes 1,000,000, and the patient of survival approximately 5,000,000～6,000,000, wherein more than 75% leave deformity in various degree, has caused white elephant to individual, family and society.And the Major Risk Factors of apoplexy is hypertension.Meanwhile, hypertension or the fuse cord of various diseases, can make the onset risk of the diseases such as coronary heart disease, heart failure and kidney disease increase.Because part hyperpietic there is no obvious clinical symptoms, hypertension is otherwise known as " the invisible killer " of human health, therefore improves the understanding to hypertension, and early prevention, treatment are in time had to extremely important meaning.
The existing western medicine numerical value that can reduce blood pressure, but cannot solve the root problem of health, complication that also cannot complication, especially visual deterioration is difficult to cure, and untoward reaction is many, and after drug withdrawal, easily recurrence, is therefore difficult to maintain curative effect.
In recent years, China's medical circle is given full play to the advantage of Chinese medicine, and hypertension has been carried out to deep basic research and clinical research.The Traditional chinese medicine medicament of current existing Hypertension has all been obtained good effect in clinical practice, is subject to patient's popular welcome.But be also not difficult to find out, the oral formulations ubiquity toxic medicament of Hypertension at present, absorbs slowly, and onset is slow, the shortcoming that Liver and kidney toxicity is large.Therefore, develop low, the rapid-action medicine of toxicity to adapt to clinical needs, have very important significance.
Summary of the invention
The object of the invention is to open one and treat hypertensive pharmaceutical composition, the present invention also aims to the preparation method of open said composition.
One involved in the present invention is treated hypertensive pharmaceutical composition, and it is mainly by the crude drug Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Plumula Nelumbinis, Rhizoma Acori Graminei, Herba Epimedii, Ramulus Uncariae Cum Uncis, Ganoderma, Semen Cassiae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Cortex Eucommiae composition.
The card that formula of the present invention cures mainly is that the Radix Paeoniae Alba is monarch drug by due to excessive rising of liver-YANG, the easing the affected liver of enriching blood, Semen Cassiae is ministerial drug, clearing away heat to improve acuity of vision, Radix Rehmanniae Preparata tonifying liver kidney yin, Herba Epimedii kidney-replenishing, tonifying both YIN and YANG, Ganoderma invigorating the spleen and replenishing QI, be adjuvant drug altogether, the Plumula Nelumbinis relieving restlessness that clears away heart-fire, Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, Folium Lycii replenishing vital essence to improve eyesight is altogether for making medicine, separately add Rhizoma Atractylodis Macrocephalae spleen reinforcing dampness, the Rhizoma Acori Graminei eliminating phlegm of having one's ideas straightened out, Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.
Nourishing the liver and kidney of the present invention, liver nourishing the moon, improving eyesight, suppressing liver-YANG.For the hypertension due to excessive rising of liver-YANG, and accompany blurred vision, disease is seen giddy, dizzy, xerostomia, bitter taste, red tongue, full and large pulse.
The consumption of Chinese medicine composition of the present invention and drug component thereof also carries out lot of experiments through inventor and draws, effect is remarkable.
A kind of composition and weight portion for the treatment of hypertensive combination of oral medication of described treatment is: Radix Paeoniae Alba 10-30 part, Semen Cassiae 5-25 part, Radix Rehmanniae Preparata 5-10 part, Herba Epimedii 5-10 part, Ganoderma 3-6 part, Plumula Nelumbinis 1-2 part, Ramulus Uncariae Cum Uncis 2-8 part, Folium Lycii 2-8 part, Rhizoma Atractylodis Macrocephalae 2-8 part, Rhizoma Acori Graminei 1-5 part, Radix Glycyrrhizae Preparata 1-5 part.
A kind of further composition and weight portion for the treatment of hypertensive combination of oral medication of described treatment is: Radix Paeoniae Alba 15-25 part, Semen Cassiae 10-20 part, Radix Rehmanniae Preparata 6-9 part, Herba Epimedii 6-9 part, Ganoderma 4-6 part, Plumula Nelumbinis 1-2 part, Ramulus Uncariae Cum Uncis 3-7 part, Folium Lycii 3-7 part, Rhizoma Atractylodis Macrocephalae 3-7 part, Rhizoma Acori Graminei 2-4 part, Radix Glycyrrhizae Preparata 1-4 part.
A kind of preferred composition and weight portion for the treatment of hypertensive combination of oral medication of described treatment is: 25 parts of the Radix Paeoniae Albas, 20 parts of Semen Cassiaes, 9 parts of Radix Rehmanniae Preparata, 8 parts of Herba Epimedii, 5 parts of Ganodermas, 1 part of Plumula Nelumbinis, 6 parts of Ramulus Uncariae Cum Uncis, 4 parts of Folium Lyciis, 5 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Rhizoma Acori Graminei, 4 parts of Radix Glycyrrhizae Preparatas.
A kind of preferred composition and weight portion for the treatment of hypertensive combination of oral medication of described treatment is: 20 parts of the Radix Paeoniae Albas, 15 parts of Semen Cassiaes, 8 parts of Radix Rehmanniae Preparata, 7 parts of Herba Epimedii, 4 parts of Ganodermas, 1 part of Plumula Nelumbinis, 3 parts of Ramulus Uncariae Cum Uncis, 3 parts of Folium Lyciis, 3 parts of Rhizoma Atractylodis Macrocephalae, 2 parts of Rhizoma Acori Graminei, 3 parts of Radix Glycyrrhizae Preparatas.
In a word, the present invention forms monarch, minister, it is various to help, make, and compatibility is rigorous, complements each other, and plays altogether nourishing the liver and kidney, the merit of suppressing the hyperactive liver and subsiding YANG.
Medicine of the present invention can add conventional adjuvant, according to common process, makes clinical acceptable tablet, granule, pill, capsule, slow releasing agent, oral liquid etc.
The preparation method of pharmaceutical composition of the present invention comprises the steps: that above ten are ground into fine powder simply, sieves, mix, and granule processed, dry, encapsulated.
The preparation method of the tablet of pharmaceutical composition of the present invention comprises the steps: above ten simply, is ground into fine powder, sieves, mix, and granule processed, dry, tabletting, makes tablet.
The preparation method of the tablet of pharmaceutical composition of the present invention comprises the steps: that above ten simply after decocting, concentrated, filters, and makes oral liquid.
The preparation method of pharmaceutical composition of the present invention preferably includes following steps: comprise the steps: above ten simply, Rhizoma Dioscoreae, Ganoderma, Ramulus Uncariae Cum Uncis and Rhizoma Acori Graminei are ground into fine powder, sieve, after all the other seven flavor medicine decocting in water, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make tablet.
The preparation method of pharmaceutical composition of the present invention preferably includes following steps: comprise the steps: above ten simply, Rhizoma Dioscoreae, Ganoderma, Ramulus Uncariae Cum Uncis and Rhizoma Acori Graminei are ground into fine powder, sieve, after all the other seven flavor medicine decocting in water, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make capsule.
For the oral formulations ubiquity toxic medicament of current Hypertension, absorb slowly, onset is slow, the shortcoming that Liver and kidney toxicity is large.The invention provides low, the rapid-action medicine of toxicity to adapt to clinical needs, fundamentally treating the hypertensive while, little to somatic damage, solve the misery that patient's vision goes down simultaneously, improve the quality of living.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
1, prescription:
25 grams of the Radix Paeoniae Albas, 20 grams of Semen Cassiaes, 9 grams of Radix Rehmanniae Preparata, 8 grams of Herba Epimedii, 5 grams of Ganodermas, 1 gram of Plumula Nelumbinis, 6 grams of Ramulus Uncariae Cum Uncis, 4 grams of Folium Lyciis, 5 grams of Rhizoma Atractylodis Macrocephalae, 5 grams of Rhizoma Acori Graminei, 4 grams of Radix Glycyrrhizae Preparatas.
2. method for making:
Above ten are ground into fine powder simply, sieve, mix, and granule processed, dry, encapsulated, make 100, obtain.
Embodiment 2
1, prescription:
20 grams of the Radix Paeoniae Albas, 15 grams of Semen Cassiaes, 8 grams of Radix Rehmanniae Preparata, 7 grams of Herba Epimedii, 4 grams of Ganodermas, 1 gram of Plumula Nelumbinis, 3 grams of Ramulus Uncariae Cum Uncis, 3 grams of Folium Lyciis, 3 grams of Rhizoma Atractylodis Macrocephalae, 2 grams of Rhizoma Acori Graminei, 3 grams of Radix Glycyrrhizae Preparatas.
2. method for making:
Above ten are ground into fine powder simply, sieve, mix, and granule processed, dry, tabletting, makes 100, tablet, obtains.
Embodiment 3
1, prescription:
18 grams of the Radix Paeoniae Albas, 14 grams of Semen Cassiaes, 7 grams of Radix Rehmanniae Preparata, 7 grams of Herba Epimedii, 6 grams of Ganodermas, 1 gram of Plumula Nelumbinis, 5 grams of Ramulus Uncariae Cum Uncis, 4 grams of Folium Lyciis, 6 grams of Rhizoma Atractylodis Macrocephalae, 3 grams of Rhizoma Acori Graminei, 2 grams of Radix Glycyrrhizae Preparatas.
2, technique:
Above ten simply after decocting, concentrated, filters, and makes oral liquid 100ml, obtains.
Embodiment 4
1, prescription:
30 grams of the Radix Paeoniae Albas, 10 grams of Semen Cassiaes, 9 grams of Radix Rehmanniae Preparata, 5 grams of Herba Epimedii, 6 grams of Ganodermas, 1 gram of Plumula Nelumbinis, 3 grams of Ramulus Uncariae Cum Uncis, 2 grams of Folium Lyciis, 8 grams of Rhizoma Atractylodis Macrocephalae, 5 grams of Rhizoma Acori Graminei, 2 grams of Radix Glycyrrhizae Preparatas.
2. method for making:
Above ten simply, and Rhizoma Dioscoreae, Ganoderma, Ramulus Uncariae Cum Uncis and Rhizoma Acori Graminei are ground into fine powder, sieves, and after all the other seven flavor medicine decocting in water, is condensed into thick paste shape, mixes granule processed with above-mentioned fine powder, dry, makes 60, tablet, obtains.
Embodiment 5
1, prescription:
22 grams of the Radix Paeoniae Albas, 18 grams of Semen Cassiaes, 6 grams of Radix Rehmanniae Preparata, 6 grams of Herba Epimedii, 6 grams of Ganodermas, 2 grams of Plumula Nelumbiniss, 3 grams of Ramulus Uncariae Cum Uncis, 3 grams of Folium Lyciis, 7 grams of Rhizoma Atractylodis Macrocephalae, 4 grams of Rhizoma Acori Graminei, 1 gram of Radix Glycyrrhizae Preparata.
2. method for making:
Above ten simply, and Rhizoma Dioscoreae, Ganoderma, Ramulus Uncariae Cum Uncis and Rhizoma Acori Graminei are ground into fine powder, sieves, and after all the other seven flavor medicine decocting in water, is condensed into thick paste shape, mixes granule processed with above-mentioned fine powder, dry, makes 50 of capsules, obtains.
Embodiment 6 tests of pesticide effectiveness
[test material]
Tested medicine: concora crush capsule: in-built chocolate brown powder, 0.4g/ grain, is made by embodiment 1, is made into required concentration with front with distilled water.
Positive control drug:.Captopril: Sino-U.S. Shanghai Shi Guibao pharmaceutical Co. Ltd produces, is mixed with 6% medicinal liquid with distilled water before using.
[test apparatus] blood pressure: by tail sleeve method with BP-98A blood pressure recording instrument from rat tail artery recording blood pressure, every 6d surveys once, surveys altogether 5 times.
[test method and result]
Get the male spontaneous hypertensive rat of clean level in 12 week age (SHR) 30, weight (220 ± 10) g, be divided into 5 groups, every group 6, i.e. administration low dose group (1.0g/kg), administration high dose group (2.0g/kg) and Captopril group (10mg/kg), model group (gavaging isometric(al) distilled water).1 time/d of administration, each administration volume is 10mL/kg, successive administration 5 weeks.
Index detects weekly and measures rat tail artery blood pressure under waking state by BP-6 noinvasive arteria caudalis blood pressure measurement analytical system.
Experimental data all represents with x ± s.Result is carried out statistical procedures with t check.The results are shown in Table 1.
The impact (mmHg, x ± s, n=10) of table 1 concora crush granule on SHR rat blood pressure
Note: with the comparison of blank group, * P < 0.05, * * P < 0.01
As shown in Table 1, concora crush granule high and low dose group all can reduce the blood pressure of SHR rat, and statistical result has remarkable statistical significance.
Embodiment 7 toxicity tests
[test material]
Tested medicine: concora crush granule: chocolate brown powder, 0.4g/ grain, is made by embodiment 1, is made into required concentration with front with distilled water.
[test method and result]
Acute toxicity test Kunming mouse 18 ± 2g used, male and female half and half.Selection is bought this laboratory and is adapted to after 3d in good conditionly, and behavior, movable N/R animal are tested.Fasting 14～16h before each animals administer, after administration, fasting 4h, can't help water.Single gastric infusion during experiment, 40mL/kg, wherein blank group waits the distilled water of capacity.Give the response situation of observation post administration animal, and the lasting 4h that observes, Continuous Observation 7d. acute toxicity test observation index: observe animal body quality, diet, outward appearance, behavior, secretions, Excreta and poisoning symptom, the initial time of toxic reaction, the order of severity, persistent period, record the death condition of animal, and respectively before administration the 3rd day (D3) after (D0), administration, the 7th day (D7) claim the animal scale of construction.
In administration 4h and in 1 week, blank group shows no obvious abnormalities reaction, and it is dead that all animals have no.The equal normal growth of each treated animal scale of construction, administration group compares with blank group, difference not statistically significant.This pharmaceutical composition safety non-toxic is described.
Claims (10)
1. the hypertensive pharmaceutical composition for the treatment of, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: Radix Paeoniae Alba 10-30 part, Semen Cassiae 5-25 part, Radix Rehmanniae Preparata 5-10 part, Herba Epimedii 5-10 part, Ganoderma 3-6 part, Plumula Nelumbinis 1-2 part, Ramulus Uncariae Cum Uncis 2-8 part, Folium Lycii 2-8 part, Rhizoma Atractylodis Macrocephalae 2-8 part, Rhizoma Acori Graminei 1-5 part, Radix Glycyrrhizae Preparata 1-5 part.
2. one according to claim 1 is treated hypertensive pharmaceutical composition, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: Radix Paeoniae Alba 15-25 part, Semen Cassiae 10-20 part, Radix Rehmanniae Preparata 6-9 part, Herba Epimedii 6-9 part, Ganoderma 4-6 part, Plumula Nelumbinis 1-2 part, Ramulus Uncariae Cum Uncis 3-7 part, Folium Lycii 3-7 part, Rhizoma Atractylodis Macrocephalae 3-7 part, Rhizoma Acori Graminei 2-4 part, Radix Glycyrrhizae Preparata 1-4 part.
3. one according to claim 2 is treated hypertensive pharmaceutical composition, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: 25 parts of the Radix Paeoniae Albas, 20 parts of Semen Cassiaes, 9 parts of Radix Rehmanniae Preparata, 8 parts of Herba Epimedii, 5 parts of Ganodermas, 1 part of Plumula Nelumbinis, 6 parts of Ramulus Uncariae Cum Uncis, 4 parts of Folium Lyciis, 5 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Rhizoma Acori Graminei, 4 parts of Radix Glycyrrhizae Preparatas.
4. one according to claim 2 is treated hypertensive pharmaceutical composition, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: 20 parts of the Radix Paeoniae Albas, 15 parts of Semen Cassiaes, 8 parts of Radix Rehmanniae Preparata, 7 parts of Herba Epimedii, 4 parts of Ganodermas, 1 part of Plumula Nelumbinis, 3 parts of Ramulus Uncariae Cum Uncis, 3 parts of Folium Lyciis, 3 parts of Rhizoma Atractylodis Macrocephalae, 2 parts of Rhizoma Acori Graminei, 3 parts of Radix Glycyrrhizae Preparatas.
5. the pharmaceutical composition as described in as arbitrary in claim 1-4, is characterized in that getting crude drug, adds conventional adjuvant, according to common process, makes clinical acceptable tablet, granule, pill, capsule, slow releasing agent, oral liquid.
6. the preparation method of the pharmaceutical composition as described in as arbitrary in claim 1-4, comprises the steps: that above ten tastes are ground into fine powder, sieves, mix, and granule processed, dry, encapsulated.
7. the preparation method of the pharmaceutical composition as described in as arbitrary in claim 1-4, comprises the steps: above ten tastes, is ground into fine powder, sieves, mix, and granule processed, dry, tabletting, makes tablet.
8. the preparation method of the pharmaceutical composition as described in as arbitrary in claim 1-4, comprises the steps: that above ten simply after decocting, concentrated, filters, and makes oral liquid.
9. the preparation method of the pharmaceutical composition as described in as arbitrary in claim 1-4, comprise the steps: above ten simply, Rhizoma Dioscoreae, Ganoderma, Ramulus Uncariae Cum Uncis and Rhizoma Acori Graminei are ground into fine powder, sieve, after boiling, all the other Six-element liquid medicine are condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make tablet or capsule.
10. the preparation method of the pharmaceutical composition as described in as arbitrary in claim 1-4, comprises the steps: above ten simply, and Rhizoma Dioscoreae, Ganoderma, Ramulus Uncariae Cum Uncis and Rhizoma Acori Graminei are ground into fine powder, sieve, after all the other Six-element liquid medicine boil, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make capsule.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552416A (en) * | 2003-06-03 | 2004-12-08 | 天津天士力制药股份有限公司 | Medicine composition application for preparing hypertension medicine |
| CN101647990A (en) * | 2009-09-09 | 2010-02-17 | 武兴战 | Traditional Chinese medicine bag for treating hypertension |
| CN101991816A (en) * | 2010-11-12 | 2011-03-30 | 李奕星 | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases |
-
2013
- 2013-12-28 CN CN201310753334.1A patent/CN103720956B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552416A (en) * | 2003-06-03 | 2004-12-08 | 天津天士力制药股份有限公司 | Medicine composition application for preparing hypertension medicine |
| CN101647990A (en) * | 2009-09-09 | 2010-02-17 | 武兴战 | Traditional Chinese medicine bag for treating hypertension |
| CN101991816A (en) * | 2010-11-12 | 2011-03-30 | 李奕星 | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases |
Non-Patent Citations (3)
| Title |
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| 于新等: "《药食同源物品使用手册 可用于保健食品的物品》", 31 July 2012, 中国轻工业出版社 * |
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| 柴瑞霞等: "《高血压饮食宜忌随身查》", 30 November 2013, 黑龙江科学技术出版社 * |
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