CN102293927B - Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof - Google Patents
Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation with antifatigue and antioxidation effects, and a preparation method thereof. The compound Chinese medicinal preparation is characterized by comprising the following components in part by weight: 2 to 10 parts of manyflower solomonseal rhizome, 3 to 10 parts of astragalus, 1 to 5 parts of American ginseng, 1 to 3 parts of lucid ganoderma, 0.5 to 1.5 parts of cordyceps sinensis, and 0.5 to 1.5 parts of cornu cervi pantotrichum. According to a formula, the medicines can be prepared into various formulations. Through the administration experiment of aging mice and crowd, compound Chinese medicinal preparation oral liquid can obviously improve the content of superoxide dismutase (SOD) and glutathione (GSH-Px) of an organism, has an effect of resisting and removing free radicals of the organism and delays the aging process; and by observing time of swimming with a load attached to the body of mice, SOD and the content of malondialdehyde (MDA), large and middle doses of the Chinese medicinal preparation can prolong the time of swimming with the load attached to the body of mice, improve the SOD activity of serum, and reduce MDA value, so that the compound Chinese medicinal preparation can enhance the antifatigue and antioxidation effects of mice by resisting free radicals.
Description
Technical field
The present invention relates to the herbal mixture field, specifically refer to a kind of Chinese traditional compound medicine with resisting fatigue and anti-oxidation function and preparation method thereof.
Background technology
With the quickening pace of modern life and other a variety of causes, many people's health is in " subhealth state " state.Be health without organic disease, but functional change has appearred, quality of life is poor, for example often feel tired, spirit is not good enough, muscle power " overdraw ", immunocompetence are low, easily catch a cold, the symptoms such as naturally-aged acceleration are in the heart, cerebrovascular or other chronic disease in earlier stage.But all do not reach the clinical diagnosis level to all indexs of examination in hospital, this is " sub-health state " concrete manifestation in our life.Long-term fatigue and human free radical increase various diseases such as may causing chronic fatigue syndrome, diabetes, hyperlipidemia, hypertension, tumor, cancer.Along with improving constantly of living standard, people more and more pay attention to health, change anosis prevention into from ill the seeing a doctor in past, to reach the purpose of the health that secures good health.Therefore the compound preparation of health food and medicine has the very large market demand.And therefore sub-health state does not also have suitable medicine it is prevented and treat at present because of without obvious organic disease.
Summary of the invention
Technical problem to be solved by this invention is that the present situation for prior art provides a kind of Chinese traditional compound medicine with resisting fatigue and anti-oxidation function, to reach the body constitution of improving people, the purpose of avoiding sub-health state.
Another technical problem to be solved by this invention is to provide a kind of preparation method with Chinese traditional compound medicine of resisting fatigue and anti-oxidation function.
The present invention solves the problems of the technologies described above the technical scheme that adopts: the Chinese traditional compound medicine that this has resisting fatigue and anti-oxidation function is characterized in that comprising the following weight component:
Rhizoma Polygonati in above-mentioned formula is the rhizome of liliaceous plant Rhizoma Polygonati, P. cyrtonema, hot river Rhizoma Polygonati, Yunnan Rhizoma Polygonati, polygonatum cirrhifolium Royle etc.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, the function of kidney tonifying.Cure mainly weakness of the spleen and stomach, fatigue and asthenia, the xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst is simultaneously very effective in cure for diabetes.
The Radix Astragali has the effect of invigorating QI to consolidate the body surface resistance, diuresis, and among the people also have the winter to get the custom that the Radix Astragali is made into the food of nourishing and fit keeping function." key medicine of QI invigorating is mended all empty not enough " from ancient times.It has good scavenging action to multiple free radical, can prevent biomembranous lipid peroxidation.
Radix Panacis Quinquefolii is medicinal and edible plant, is famous and precious top grade Chinese medicine, is again the high-grade nourishing good merchantable brand.Have anticancer, resisting fatigue, anti-hypoxia, radioprotective, the anti-ageing several functions of waiting for a long time, coronary heart disease, hypertension, anemia, neurosis, diabetes etc. are had good curative effect.Often take Radix Panacis Quinquefolii, but building body, life lengthening.
Ganoderma is called as " Herba mesonae chinensis ", enters the five internal organs, and the gas of completion body is so a little less than the heart, lung, liver,spleen,kidney deficiency of five ZANG-organs, all can take it.Have strengthening the body resistance, strengthen immunologic function, improve the great function of Abwehrkraft des Koepers.Effect with antitumor, anticancer, defying age, antiallergic, treatment hypertension, diabetes, beauty treatment.
Cordyceps has the effect of " reason weakness ", and effect and Radix Ginseng are similar, can control weakness, get Yinyang entirely also with it.The property of medicine is gentle, and old and young sick empty person all should eat.
Cornu Cervi Pantotrichum is good at kidney invigorating and YANG supporting, and spermatogenesis benefit blood is mended the strong bone of marrow.The Cornu Cervi Pantotrichum property of medicine is temperature partially, and is can tonifying YANG but not dry, and companion's Yin-nourishing prescription use can yin nourishing and oiliness, takes so be well suited for the old people.For the degenerative disease of skeletal system, and the function of other internal organs weakens gradually and many morbid state occurs, breathes heavily as frequent urination at night and sexual impotence erectile problem, failure of the kidney in receiving QI, the not good key of kidney and ear tinnitus of deficiency type, and even becoming deaf etc. has certain curative effect!
This Chinese traditional compound medicine is take Rhizoma Polygonati, the Radix Astragali, Radix Panacis Quinquefolii as principal agent, be aided with Ganoderma, Cordyceps and Cornu Cervi Pantotrichum, from Chinese medicine health-care essence, gas, refreshing three aspects: Zishen fill fine, invigorating QI to consolidate the body surface resistance, nourishing blood to tranquillize the mind, from the human body five elements start with tranquilizing by nourishing the heart, kidney tonifying, essence replenishing, strong board appetizing, lung moistening YIN nourishing, hemopoietic nourishing the liver, thereby reach YIN and YANG balancing, the five internal organs with benefit, enhancing immunity, resisting fatigue and antioxidative effect.
Above-mentioned preparation method with Chinese traditional compound medicine of resisting fatigue and anti-oxidation function is characterized in that comprising the steps:
1) take in proportion described Rhizoma Polygonati, the Radix Astragali, Radix Panacis Quinquefolii, Ganoderma, Cordyceps and Cornu Cervi Pantotrichum, join in the water of 8-12 times of above-mentioned substance gross weight and decocted 1-3 hour, filter, obtain filtrate and filtering residue for the first time;
2) again add 6-10 doubly to boil 0.5-1.5 hour to the decocting of filtering residue weight in described filtering residue, filter, obtain filtrate for the second time;
3) merge for the first time filtrate and for the second time filtrate obtain filtrate;
4) be mixed with oral liquid, concrete steps are as follows:
After being concentrated into relative density 1.05-1.15 after described filtrate high speed centrifugation, add purified water, flavoring agent to be mixed with oral liquid; Described flavoring agent is selected oligosaccharide syrup, white sugar or sweeting agent etc. usually; The consumption of purified water and flavoring agent consumption use routinely gets final product; Described relative density is that density take water is as reference;
Perhaps granulation agent, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; Then add the granule adjuvant to do soft material in extractum, make the wet granular oven dry, fill becomes granule;
Wherein, described adjuvant is flavoring agent and magnesium stearate; Described flavoring agent can be Icing Sugar, maltodextrin, glucose and/or sweeting agent etc.; The addition of adjuvant consumption routinely gets final product;
Perhaps be mixed with pill, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; Add the pill adjuvant in extractum, make soft material; Then make wet ball with pellet processing machine, oven dry, coating is packaged into pill;
The part by weight of described extractum and adjuvant is 1: 2～4, and wherein said adjuvant is starch, maltodextrin and/or microcrystalline Cellulose;
Perhaps be mixed with capsule, tablet or soft capsule, concrete steps are as follows:
Described filtrate centrifugal concentrating to relative density 1.2～1.4, is pulverized after vacuum drying, added adjuvant to make tablet or capsule; Wherein prepare tablet adjuvant used and be selected from lactose, microcrystalline Cellulose, starch, dextrin and/or magnesium stearate etc., preparation soft capsule adjuvant used can be selected vegetable oil and Cera Flava etc.
Chinese traditional compound medicine oral liquid provided by the present invention, by to significantly improving body superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) content through mouse aging and crowd are taken evidence, have opposing and remove body Free Radical, slow down aging process; Observe mice burden swimming time, serum superoxide dismutases (SOD), malonaldehyde (MDA) content value, the big or middle dosage of result proof this product can extend the mice burden swimming time, activity of SOD in serum is increased, the MDA value descends, and illustrates that this product can strengthen the mouse anti-reflecting fatigue effect by free radical resisting.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
Rhizoma Polygonati 4.0kg, Radix Astragali 10.0kg, Radix Panacis Quinquefolii 5.0kg, Ganoderma 3.0kg, Cordyceps 1.5kg, Cornu Cervi Pantotrichum 1.5kg adds water 250kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 200kg decoction 1 hour in filtering residue, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
To be concentrated into 20L after the filtrate high speed centrifugation, the oligosaccharide syrup 25kg, potassium sorbate 0.165kg, the purified water 5kg that then add are mixed with oral liquid 50L, and boiling sterilization 30 minutes is up to the standards, and fill obtains 1000 of oral liquids.
Its mouse oral gives this product oral liquid 30d, adopts the swimming with a load attached to the body experiment, observes the mice swimming death time; After the swimming certain hour, blood sampling detects the serum urea nitrogen content; Getting liver detects hepatic glycogen content and measures mice in the variation of motion and quiet front and back Serum lactic acid content.Result shows that the mice burden swimming time obviously extends, and the serum urea nitrogen content that produces during motion reduces, and hepatic glycogen content increases, and motion finishes that the elimination value of blood lactic acid increases after quiet 20min, and on weight of mice without impact.Presentation of results this product has the effect of alleviating the mice physical fatigue.
Embodiment 2
Rhizoma Polygonati 6kg, Radix Astragali 3kg, Radix Panacis Quinquefolii 1.0kg, Ganoderma 1.0kg, Cordyceps 1.0kg, Cornu Cervi Pantotrichum 0.8kg adds water 128kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 10.2kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.3 left and right, adds Icing Sugar 5.7g to make soft material, after 14 eye mesh screens filter in oscillating granulator granulation, then 60 ℃ of oven dry, after 14 eye mesh screens arrange, add 25g silicon dioxide, make 2000 bags of granules.
Embodiment 3
Rhizoma Polygonati 6.0kg, Radix Astragali 6.0kg, Radix Panacis Quinquefolii 1.0kg, Ganoderma 1.0kg, Cordyceps 0.5kg, Cornu Cervi Pantotrichum 1.0kg adds water 155kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 124kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.3 left and right, adds starch 9.3kg to make soft material, make wet ball with pellet processing machine, 65 ℃ of oven dry, dried ball coating, packing is made 100000 of pills.
Embodiment 4
Rhizoma Polygonati 4.0kg, Radix Astragali 4.0kg, Radix Panacis Quinquefolii 1.2kg, Ganoderma 1.2kg, Cordyceps 0.5kg, Cornu Cervi Pantotrichum 0.5kg adds water 114kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 91.2kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.27, vacuum-0.008Mpa, 80 ℃ of dryings, pulverize at low temperature adds lactose 1.2kg, medicinal alcohol 0.5kg makes soft material, and 14 eye mesh screens are made wet granular, 60 ℃ of oven dry, 14 mesh sieve granulate, add the 30g magnesium stearate, mixing, tabletting is made 20000, tablet.
Adopt the nape subcutaneous injection D-of section galactose to set up aging model, give continuously mouse stomach 30d with this product tablet with 2.0g/k gd and 4.0g/kgd, and do the blank group with the normal saline gavage.This product tablet can significantly improve the activity (P＜0.01) of superoxide dismutase (SOD) in D-galactose D-Aging mice serum as a result, significantly reduce the activity (P＜0.01) of malonaldehyde (MDA), and can improve the activity of glutathion (PSH-PX).Presentation of results this product is set up mouse aging to the D-galactose antioxidation preferably.
Embodiment 5
Rhizoma Polygonati 5.0kg, Radix Astragali 4.0kg, 1.0 parts of Radix Panacis Quinquefoliis, 1.0 parts of Ganodermas, 0.8 part of Cordyceps, 0.8 part, Cornu Cervi Pantotrichum adds water 126kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 100.8kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.27, vacuum-0.008Mpa, 80 ℃ of dryings, pulverize at low temperature, add starch 1.7kg, medicinal alcohol 0.56kg makes soft material, and 14 eye mesh screens are made wet granular, 60 ℃ of oven dry, 14 mesh sieve granulate add the 30g magnesium stearate, mixing, capsule charge is made 20000 of capsules.
Embodiment 6
Rhizoma Polygonati 5.0kg, Radix Astragali 3.0kg, Radix Panacis Quinquefolii 1.5kg, Ganoderma 1.0kg, Cordyceps 0.5kg, Cornu Cervi Pantotrichum 0.5kg adds water 115kg and decocted 2 hours, filters, and obtains filtrate and filtering residue for the first time.
Add water 92kg to filtering residue and decocted 1 hour, filter, obtain filtrate for the second time.
Merge for the first time filtrate and for the second time filtrate obtain filtrate.
Filtrate is concentrated into relative density 1.28, vacuum-0.008Mpa, 80 ℃ of dryings, pulverize at low temperature is crossed 100 mesh sieves, and the 0.3kg Cera Flava is added appropriate vegetable oil, heating and melting, add residue vegetable oil mix homogeneously, vegetable oil is 4.7kg altogether, after oily wax mixture temperature drops to below 40 ℃, extract powder is added in above-mentioned oily wax mixture, mix homogeneously, cross 100 mesh sieves, standing 30 minutes de-bubbled, 10000 of soft capsules are made in fill.
Claims (2)
1. Chinese traditional compound medicine with resisting fatigue and anti-oxidation function is characterized in that being made by the crude drug of following weight:
2. the preparation method with Chinese traditional compound medicine of resisting fatigue and anti-oxidation function as claimed in claim 1, is characterized in that comprising the steps:
1) take in proportion described Rhizoma Polygonati, the Radix Astragali, Radix Panacis Quinquefolii, Ganoderma, Cordyceps and Cornu Cervi Pantotrichum, join in the water of 8-12 times of above-mentioned substance gross weight and decocted 1-3 hour, filter, obtain filtrate and filtering residue for the first time;
2) again add 6-10 doubly to boil 0.5-1.5 hour to the decocting of filtering residue weight in described filtering residue, filter, obtain filtrate for the second time;
3) merge for the first time filtrate and for the second time filtrate obtain filtrate;
4) be mixed with oral liquid, concrete steps are as follows:
After described filtrate high speed centrifugation is concentrated into relative density 1.05-1.15, add purified water and/or flavoring agent to be mixed with oral liquid;
Perhaps granulation agent, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; Then add the granule adjuvant to do soft material in extractum, make the wet granular oven dry, fill becomes granule;
Perhaps be mixed with pill, concrete steps are as follows:
Described filtrate directly is concentrated into relative density 1.2-1.5, obtains extractum; Add the pill adjuvant in extractum, make soft material; Then make wet ball with pellet processing machine, oven dry, coating is packaged into pill;
The part by weight of described extractum and adjuvant is 1: 2～4, and wherein said adjuvant is selected from starch, maltodextrin and/or microcrystalline Cellulose, and the addition of each material consumption use routinely gets final product;
Perhaps be mixed with capsule, tablet or soft capsule, concrete steps are as follows:
Described filtrate centrifugal concentrating to relative density 1.2～1.4, is pulverized after vacuum drying, added capsule, additive of tablet, make capsule, tablet; Or add the soft capsule adjuvant to make soft capsule; Wherein, described capsule, tablet dressing can be lactose, microcrystalline Cellulose, starch, dextrin and/or magnesium stearate etc., and described soft capsule adjuvant can be the materials such as vegetable oil and Cera Flava.
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| CN103211219B (en) * | 2013-04-25 | 2014-08-20 | 福建永生活力生物工程有限公司 | Health food for relieving physical fatigue and preparation method thereof |
| CN104857046A (en) * | 2014-02-20 | 2015-08-26 | 吉林大清鹿苑保健科技有限公司 | Panax quinquefolius-hairy antler particles and preparation method thereof |
| CN106309910A (en) * | 2016-04-09 | 2017-01-11 | 王书德 | Cordyceps sinensis kidney pancreas pill |
| CN107744564A (en) * | 2016-08-10 | 2018-03-02 | 杨丛刚 | A kind of benefiting qi and nourishing blood, the antler health-care product of strengthen immunity and preparation technology |
| CN106138715A (en) * | 2016-09-27 | 2016-11-23 | 杭州本草养正堂生物科技有限公司 | A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue |
| CN106266573A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of resisting fatigue, the compound preparation and preparation method thereof of defying age |
| CN108175825A (en) * | 2017-01-25 | 2018-06-19 | 青海春天药用资源科技利用有限公司 | For tonifying Qi of the kidney, pharmaceutical composition of invigorating the spleen moistening lung and preparation method thereof |
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