CN100368006C - Medicine for treating cardiovascular disease - Google Patents
Medicine for treating cardiovascular disease Download PDFInfo
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- CN100368006C CN100368006C CNB2005100206344A CN200510020634A CN100368006C CN 100368006 C CN100368006 C CN 100368006C CN B2005100206344 A CNB2005100206344 A CN B2005100206344A CN 200510020634 A CN200510020634 A CN 200510020634A CN 100368006 C CN100368006 C CN 100368006C
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Landscapes
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Abstract
The present invention relates to a medicine for treating cardiovascular diseases. The medicine is composed of the following raw materials according to the proportion by weight: a compounding agent of gingko and rhizoma coridalis, a ganoderma extract, uncaria, fleeceflower root, achyranthes root, hemlock parsley, epimedium herb, dodder seed, semen cassiae, gardenia, rhubarb, slender dutchmanspipe root, dahurian angelica, white peony root, angelica, hematite, tuckahoe, pinellia tuber, gentian, common yan rhizome, forsythia fruit, chrysanthemum, dried tangerine peel, cinnabar, polygala root, seaweed, barbary wolfberry fruit, magnetite, concha haliotidis, nacre, sophora fruit, unprocessed rehmannia root, baical skullcap root, eucommia bark, figwort root, spica prunellae, spine date seed, common st. paulswort, Chinese arborvitae kernel, mulberry leaf, solomonseal rhizome, glossy privet fruit, round cardamon fruit, motherwort, menthol, borneol, morinda root, Chinese taxillus twig, dendrobium, palmleaf raspberry pruit, amomun fruit, tree peony bark, bile arisaema, condensed buffalo horn powder, nutgrass galingale rhizome, tabasheer, earthworm, tangerine pith, dutohmanspipe fruit, tall gastrodis tuber and red sage root. The medicine has the functions of softening expanded blood vessels and anticoagulation thrombolysis, and lays emphasis on the comprehensive regulation of human bodies to enhance the self resistance ability to eradicate the relapse of thrombotic diseases. Thus, both manifestations and root cause of diseases are treated.
Description
One, technical field
The present invention relates to the Chinese medicine compound, thing is not the Chinese medicine composition that is used for the treatment of cardiovascular disease.
Two, background technology
According to the aged association of China statistics, the old man of China's population more than 60 years old surpassed 1.3 hundred million and with average annual 3.2% speed increment, will enter aged country soon.Since the natural law, with the growth at age, the also constantly aging decline of physiological function, various diseases increases thereupon, is that the disease patient serves as general with heart and brain blood especially.Except the old people easily suffers from this disease, a lot of brain workers, the crowd that adiposis patient is suffered from this disease and threatened by this disease is more general.According to reports, in recent years, in student group, the trend that also exists hypertension, hyperlipidemia phenomenon increasing rapidly.Because morbidity the time breaks with tremendous force, life-threatening is serious, in case rescue untimelyly, dead danger is just arranged.Though rescuing through in time of having survives extremely, often causes sequela such as hemiplegia or paralysis again, and be painful greatly to constituting the latter half of one's life, brings incomparable trouble to the household, causes more burden to society.Be known as by medical circle and be human first killer!
After Folium Ginkgo extract Egb761 was released in German Shi Wabei pharmaceutical factory, one took the upsurge of Folium Ginkgo extract to cause the whole world, and only Germany just ate up 500,000 in one day, 6,000,000 of the annual consumptions in the whole world, mainly dizzy in order to treat, tinnitus and cerebrovascular disease.
The main active ingredient of Folium Ginkgo is native compound matter such as total flavone glucoside and bilobalide.Total flavone glucoside has the function of removing free radical, except the effect that blood vessel dilating is arranged, can also prevent arteriosclerosis; Bilobalide then has the effect of anti-platelet activating factor, can improve blood circulation, avoids lipocyte to be subjected to the injury of hypoxia.And side effect is little, so market is vigorous.
With the Folium Ginkgo extract is the various product of raw material, and annual sales amount reaches more than 500,000,000 dollars on Asia, market, Europe, and only Ginkgo oral liquid annual sales amount of France is just above 6,000 ten thousand dollars.Nearly 2,000,000,000 dollars of U.S.'s annual sales amount and transit volume.
The resource of China ginkgo accounts for the whole world more than 70%.Ancient Chinese medicine is absorbed in the development and use of ginkgo nut more, and being American-European scientists on the contrary is placed on the research and the medicinal aspect of Folium Ginkgo to focus, generally is used for the treatment of cardiovascular and cerebrovascular disease, has obtained certain effect.In recent years, also to emerge many be the healing potion of Main Ingredients and Appearance with the Folium Ginkgo extract in the domestic market." a kind of Chinese medicine (application number 01119823) for the treatment of coronary heart disease, blood fat reducing, improvement sleep, " a kind of Chinese medicine composition for the treatment of coronary heart disease " (application number 02130822) etc. that disclose as Chinese patent literature; Cost is generally too high, and the vast sufferer masses do not dare to inquire.Its weak point also is, one is the reflux leaching technology of solvent with alcohol owing to adopt traditional to the extraction of effective component of ginkgo leaf, thereby causes Folium Ginkgo Chinese medicine loss of active ingredients bigger; Its two, the Chinese medicine preparation based on Folium Ginkgo extract is a lot of in the market, finds that after taking for a long time simple ginkgo leaf extract preparation can make gastrointestinal upset, constipation, bad reflections such as weak or increased heart rate.And other is based on the Chinese traditional compound medicine of Folium Ginkgo extract, biases toward nutrition, can't resolve root problem aspect softening, blood vessel dilating, anticoagulant, the thrombolytic.As: in anticoagulant and thrombolytic, activated blood coagulation system again, thereby produced a large amount of bind thrombins, caused old thrombosis not eliminate, new thrombosis forms again.Be difficult to fundamentally form radical cure to hypertension.
Three, summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of cardiovascular disease, it is that main body is formed Chinese traditional compound medicine with the Folium Ginkgo extract, in softening, blood vessel dilating, anticoagulant and thrombolytic, focus on comprehensive conditioning to body, strengthen patient's self resistivity, cardiovascular disease is reached good curative effect.
Another object of the present invention provides the preparation method of the raw material Semen Ginkgo Rhizoma Corydalis complexing agent of said medicine.
The object of the present invention is achieved like this: a kind of medicine for the treatment of cardiovascular disease, and it is the medicament of being made by the following weight proportion raw material:
Semen Ginkgo Rhizoma Corydalis complexing agent 42-46, Ganoderma extract 20-24, Ramulus Uncariae Cum Uncis 21-24, Radix Polygoni Multiflori 18-22, Radix Achyranthis Bidentatae 34-38, Rhizoma Chuanxiong 11-14, Herba Epimedii 20-24, Semen Cuscutae 18-22, Semen Cassiae 18-22, Fructus Gardeniae 18-22, Radix Et Rhizoma Rhei 8-12, Radix Aristolochiae 11-14, Radix Angelicae Dahuricae 24-28, Radix Paeoniae Alba 18-22, Radix Angelicae Sinensis 18-22, Haematitum 31-34, Poria 13-17, Rhizoma Pinelliae 18-22, Radix Gentianae 3-5, Rhizoma Dioscoreae 26-30, Fructus Forsythiae 4-6, Flos Chrysanthemi 14-18, Pericarpium Citri Reticulatae 20-24, Cinnabaris 9-11, Radix Polygalae 18-22, Sargassum 28-32, Fructus Lycii 18-22, Magnetitum 21-25, Concha Haliotidis 21-25, Concha Margaritifera 18-22, Fructus Sophorae 12-14, Radix Rehmanniae 23-27, Radix Scutellariae 18-22, Cortex Eucommiae 18-22, Radix Scrophulariae 21-25, Spica Prunellae 24-28, Semen Ziziphi Spinosae 31-35 Herba Siegesbeckiae 31-35, Semen Platycladi 18-22, Folium Mori 18-22, Rhizoma Polygonati 13-17, Fructus Ligustri Lucidi 11-15, Fructus Amomi Rotundus 16-20, Herba Leonuri 24-28, Mentholum 2-4, Borneolum Syntheticum 3-5, Radix Morindae Officinalis 18-22, Herba Taxilli 11-15, Herba Dendrobii 10-14, Fructus Rubi 8-12, Fructus Amomi 13-17, Cortex Moutan 6-8, Arisaema Cum Bile 16-20, Pulvis Cornus Bubali Concentratus 10-12, Rhizoma Cyperi 16-20, Concretio Silicea Bambusae 8-12, Pheretima 10-14, Vascular aurantii 13-17, Fructus Aristolochiae 14-18, Rhizoma Gastrodiae 18-22, Radix Salviae Miltiorrhizae 16-20; Said Semen Ginkgo Rhizoma Corydalis complexing agent be with Folium Ginkgo through the product of the extract of lime liquor and Rhizoma Corydalis and dilute sulfuric acid reaction mix mutually chemical reaction takes place after, remove the resulting product of calcium sulfate.
Another object of the present invention is achieved in that the preparation method of raw material Semen Ginkgo Rhizoma Corydalis complexing agent of the medicine of above-mentioned treatment cardiovascular disease; Carry out according to the following steps:
A) preparation of Folium Ginkgo extract
1 part of Folium Ginkgo is ground into the fragment about 2mm after the washing drying, 10 parts of the lime liquors of adding PH=8-10 soak and boil 2 hours, filter time filtrate of winning; Filtering residue adds 8 parts of identical lime liquors again, soaks to boil 1.5 hours, filter filtrate for the second time; Merge gained filtrate twice, and reduction vaporization to 27 ° Be ', after ethanol is removed impurity, and with after the recovery of ethanol reduction vaporization, the Folium Ginkgo extract that makes 27 ° of Be ' is standby;
B) Rhizoma Corydalis is broken for powdery, and adds dilute sulfuric acid, soak the solution that obtains Rhizoma Corydalis alkaloid sulfate;
C) solution of Folium Ginkgo extract with Rhizoma Corydalis alkaloid sulfate is mixed, after the reaction, remove calcium sulfate after filtration, concentrate, crystallization makes this complexing agent.
The principles of formulating prescriptions of the present invention:
Western medicine and medical practitioners grows up on anatomical basis, and more treatment biases toward and take stopgap measures, and Chinese medicine then is to grow up on the basis of clinical diagnostics.Emphasizing that specimen all controls, is that to increase with arteriotony be a kind of frequently-occurring disease, the commonly encountered diseases of main clinical manifestation for hypertension.Except that blood pressure increases, often with the giddy of varying degree, feeling of fullness in the head, neck pain, dizzy, tinnitus, agitation, limb fiber crops, insomnia, dreaminess, have still with symptoms such as cardiopalmus, uncomfortable in chest, frequent micturitions.
Though having special topic to primary disease, TCM Document do not discuss, then many to the record of above-mentioned symptom (as dizzy, tinnitus, headache, limb fiber crops etc.), and also detailed.To its cause of disease, the successive dynasties, traditional Chinese medical science famous expert had multiple theories such as wind, fire, expectorant, void.Recently relatively consistent view thinks that the fundamental cause of primary disease is an imbalance of YIN and YANG more, the deficiency of YIN excess of YANG, deficiency of both YIN and YANG very then, its disease being located in the liver, its root be at kidney, thus treatment many from Liver and kidney two through starting with, press down positive with tonifying YIN.
The hepatic and renal YIN deficiency is deficiency of both the heart and spleen then, is to be deficiency in origin, and the high Sheng of liver-yang is for marking reality, and it is reddish brown to show as complexion, red tongue, and yellow and thin fur, stringy pulse etc., so that hyperactivity of fire is given birth to expectorant, wind symptom, and then the aggravation deficiency of YIN more very then can undermine kidney yang, cause deficiency of both YIN and YANG.So many taking into account when tonify deficiency effects a permanent cure of the traditional Chinese medical science taken stopgap measures.Promptly adopt nourishing the liver and kidney, suppressing the hyperactive liver and subsiding YANG, liver heat removing pathogenic fire reducing, nourish heart and method of treatment such as blood, spleen invigorating eliminating phlegm, reach the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.
The present invention is the Chinese medicine and pharmacy theory traditional according to China, in softening, blood vessel dilating, anti-thrombolytic, focus on comprehensive conditioning to body, strengthen self resistivity, form thrombin inhibitor effectively, with the fibrinolytic agent combination,, reach the purpose for the treatment of both the principal and secondary aspects of a disease to eradicate the thrombotic disease recurrence.
Build the adopted synthesizations in side such as water jar soup, Jing-Yue Complete Works Bolus as a Kidney-Yin-Tonic, Yougui Wan, the kidney-Yang-Reinforcing Bolus, " Medicine Comprehended " Rhizoma Pinelliae atractylodes decoction and cut out with reference to " the miscellaneous diseases card is controlled new meaning " TIANMA GOUTENG YIN, " Records of Tradition Chinese and Western Medicine in Combination ".And adopt new compound Semen Ginkgo Rhizoma Corydalis complexing agent, get it and have blood vessel dilating and prevent arteriosclerosis, anticoagulant and thrombolytic, improve blood circulation, pain relieving, invigorate blood circulation, comprehensive functions such as promoting the circulation of QI, tranquilizing soporific, spasmolytic.And Ganoderma extract has bone and muscle strengthening, sharp joint, blood pressure lowering, blood fat reducing, the effect such as sensible of calming the nerves.The two thinks assistant.
With nourishing the liver and kidney such as Radix Rehmanniae, Fructus Lycii, the Cortex Eucommiae, Radix Morindae Officinalis, Herba Taxilli, Herba Epimedii, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Radix Achyranthis Bidentatae (stir-fry), Rhizoma Polygonati, Semen Cuscutae, Fructus Rubi, Herba Dendrobiis, be to be monarch.
With suppressing the hyperactive liver and subsiding YANG, is to be minister with Pulvis Cornus Bubali Concentratus, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Rhizoma Cyperi, Concha Margaritifera, Concha Haliotidis, Herba Siegesbeckiae, Magnetitum, Haematitum, Pheretima, Flos Chrysanthemi etc.
With liver heat removing pathogenic fire reducing such as the Fructus Sophorae, Semen Cassiae (stir-fry), Folium Mori, Spica Prunellae, Fructus Aristolochiae, Mentholum, Radix Aristolochiae, Radix Scutellariae, Radix Scrophulariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Radix Gentianae, Cortex Moutans.Transferring stomach with spleen invigorating such as Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, Fructus Amomi Rotunduss is to be assistant.With eliminating phlegm such as Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae, the Rhizoma Pinelliae, Poria, Vascular aurantii, Arisaema Cum Bile, Borneolum Syntheticum, Concretio Silicea Bambusae, Fructus Forsythiae, Sargassums; With Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Leonuri, Cinnabaris (grinding superfine), Radix Polygalae, Semen Platycladi, Semen Ziziphi Spinosae (stir-fry) nourishes heart and blood, is for making.Aspect nature and flavor, total prescription of make suring is cold not warm, not warm not cool; Little hardship, Hui Tian, non-stimulated.
Concocting method: above all flavor medicines, except that Mentholum, Borneolum Syntheticum, Semen Ginkgo Rhizoma Corydalis complexing agent, Ganoderma extractant, Pulvis Cornus Bubali Concentratus, Cinnabaris (powder), oven dry such as Ramulus Uncariae Cum Uncis, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Semen Cassiae (stir-fry), Radix Angelicae Sinensis, Poria, the Rhizoma Pinelliae, Rhizoma Dioscoreae, Fructus Forsythiae, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae, Rhizoma Cyperi, Concretio Silicea Bambusae, Radix Salviae Miltiorrhizae, Cortex Moutan, the Cortex Eucommiae, Pheretima, Vascular aurantii, Rhizoma Gastrodiae are ground into fine powder.All the other are smashed to coarse powder, and decocting twice added the octuple decocting 3 hours for the first time, add for the second time six times of decoctings 2 hours, filter, merging filtrate is heated to 27 ° of Be ' and adds Semen Ginkgo Rhizoma Corydalis complexing agent, Ganoderma extract, Pulvis Cornus Bubali Concentratus, Cinnabaris powder, again with above-mentioned fine powder mixing, continue to concentrate, oven dry, the cooling back adds Mentholum, Borneolum Syntheticum mixing, pulverized 100 mesh sieves, the Capsules of packing into No. 2.Bottled 100/bottle.
Instructions of taking: ante cibum oral 1-4 grain/time, 3 times/day.
Storage: sealing, moistureproof, lucifuge, put shady and cool place.
Taboo: clothes are avoided in cat fever, and perioperatively was withdrawn in one month, anemia of pregnant woman and the careful clothes of heart failure person.
Characteristics of the present invention and advantage:
1, the refinement mode of exclusive Folium Ginkgo and Semen Ginkgo Rhizoma Corydalis complexing agent: the present industrialization refinement method of Folium Ginkgo, adopt traditional is solvent with the alcohols more; Reflux is leached, and gets the mixture of multiple flavonoid after purifying, make with extra care, purifying, and is used for pharmaceutical tablet or injection.This method, technological process is long, and operation sequence is numerous and diverse, the product costliness.In the process some with material tool toxic, unfavorable to environmental protection.Simultaneously, owing to emphasize the pure property of medicine, make the active ingredient loss in the Folium Ginkgo more.And final gained also is purified relatively mixture; Also have the expert to propose, use the water boil lixiviate, gelatin cohesion, freezing remove impurity after, orange transparent Folium Ginkgo juice, in order to be mixed with various beverages.Though this method expense is low, simple, does not more make full use of its active ingredient.
This method is to utilize the effective ingredient in the Folium Ginkgo to have the architectural characteristic of phenolic hydroxyl group, adopts sig water to boil the way of leaching, makes the active ingredients such as flavonoid and bilobalide can be by abundant extraction and application.Simultaneously, a large amount of insoluble matters such as wood fibre also filter out excessively.Chlorophyll, cured matter, tannin, colloid etc. are present in the lixiviating solution, and through the ethanol clarifying treatment, major part is also removed, and are remaining a small amount of, can not influence the curative effect of medicine.As for contained microelements of calcium, phosphorus, potassium, sodium etc., all be the beneficial element that human body must often replenish.And harmful element lead, arsenic, hydrargyrum equal size all (are seen attached list) in the national Specification scope.
The physiologically active of Semen Ginkgo Rhizoma Corydalis complexing agent of the present invention is stronger, and comprehensive therapeutic effect is better.
2, become compound preparation according to the mutual combined copy of active ingredient physicochemical characteristics that is equipped with single medicinal material:
Chinese medicine is to grow up on the basis of clinical treatment experience, and the medication of the traditional Chinese medical science exists exactly: under the theoretical direction of " dialectical opinion is controlled ", sum up in clinical practice and conclude.In fact, the chemical analysis of every flavor Chinese medicine itself is just very complicated, can play the physiologically active composition of therapeutical effect to certain specified disease, only accounts for a few percent, some thousandths of, ten thousand/several.As: reserpine in Radix Rauvolfiae, d1-tetrahydrochysene horse Martin in Rhizoma Corydalis.A lot of compositions are not had a physiologically active, can not play the effect of curing the disease.Even have also poisonous harmful to human body.The present invention is according to traditional Chinese medical science pathological diagnosis, according to monarch, minister, help, make the needs of reasonable formula, and will be with behind the active ingredient purification of Chinese medicine, respectively by its physicochemical property, combined copy becomes compound preparation mutually, makes the capsule of taking convenience, has the advantage of microminiaturization, high curative effect, quick-actingization.
Four, the specific embodiment
Embodiment 1
The present invention's (also claiming self-sufficient and strategically located region good for cardio-and cerebro-vessels capsule) prescription following (weight portion, down together):
Semen Ginkgo Rhizoma Corydalis complexing agent 42, Ganoderma extract 20, Ramulus Uncariae Cum Uncis 21, Radix Polygoni Multiflori 18, Radix Achyranthis Bidentatae 34, Rhizoma Chuanxiong 11, Herba Epimedii 20, Semen Cuscutae 18, Semen Cassiae 18, Fructus Gardeniae 18, Radix Et Rhizoma Rhei 8, Radix Aristolochiae 11, the Radix Angelicae Dahuricae 24, the Radix Paeoniae Alba 18, Radix Angelicae Sinensis 18, Haematitum 31, Poria 13, the Rhizoma Pinelliae 18, Radix Gentianae 3, Rhizoma Dioscoreae 26, Fructus Forsythiae 4, Flos Chrysanthemi 14, Pericarpium Citri Reticulatae 20, Cinnabaris 9, Radix Polygalae 18, Sargassum 28, Fructus Lycii 18, Magnetitum 21, Concha Haliotidis 21, Concha Margaritifera 18, the Fructus Sophorae 12, Radix Rehmanniae 23, Radix Scutellariae 18, the Cortex Eucommiae 18, Radix Scrophulariae 21, Spica Prunellae 24, Semen Ziziphi Spinosae 31 ， Herba Siegesbeckiaes 31, Semen Platycladi 18, Folium Mori 18, Rhizoma Polygonati 13, Fructus Ligustri Lucidi 11, Fructus Amomi Rotundus 16, Herba Leonuri 24, Mentholum 2, Borneolum Syntheticum 3, Radix Morindae Officinalis 18, Herba Taxilli 11, Herba Dendrobii 10, Fructus Rubi 8, Fructus Amomi 13, Cortex Moutan 6, Arisaema Cum Bile 16, Pulvis Cornus Bubali Concentratus 10, Rhizoma Cyperi 16, Concretio Silicea Bambusae 8, Pheretima 10, Vascular aurantii 13, Fructus Aristolochiae 14, Rhizoma Gastrodiae 18, Radix Salviae Miltiorrhizae 16;
Embodiment 2
The present invention's (also claiming self-sufficient and strategically located region good for cardio-and cerebro-vessels capsule) prescription following (weight portion, down together):
Semen Ginkgo Rhizoma Corydalis complexing agent 46, Ganoderma extract 24, Ramulus Uncariae Cum Uncis 24, Radix Polygoni Multiflori 22, Radix Achyranthis Bidentatae 38, Rhizoma Chuanxiong 14, Herba Epimedii 24, Semen Cuscutae 22, Semen Cassiae 22, Fructus Gardeniae 22, Radix Et Rhizoma Rhei 12, Radix Aristolochiae 14, the Radix Angelicae Dahuricae 28, the Radix Paeoniae Alba 22, Radix Angelicae Sinensis 22, Haematitum 34, Poria 17, the Rhizoma Pinelliae 22, Radix Gentianae 5, Rhizoma Dioscoreae 30, Fructus Forsythiae 6, Flos Chrysanthemi 18, Pericarpium Citri Reticulatae 24, Cinnabaris 11, Radix Polygalae 22, Sargassum 32, Fructus Lycii 22, Magnetitum 25, Concha Haliotidis 25, Concha Margaritifera 22, the Fructus Sophorae 14, Radix Rehmanniae 27, Radix Scutellariae 22, the Cortex Eucommiae 22, Radix Scrophulariae 25, Spica Prunellae 28, Semen Ziziphi Spinosae 35 ， Herba Siegesbeckiaes 35, Semen Platycladi 22, Folium Mori 22, Rhizoma Polygonati 17, Fructus Ligustri Lucidi 15, Fructus Amomi Rotundus 20, Herba Leonuri 28, Mentholum 4, Borneolum Syntheticum 5, Radix Morindae Officinalis 22, Herba Taxilli 15, Herba Dendrobii 14, Fructus Rubi 12, Fructus Amomi 17, Cortex Moutan 8, Arisaema Cum Bile 20, Pulvis Cornus Bubali Concentratus 12, Rhizoma Cyperi 20, Concretio Silicea Bambusae 12, Pheretima 14, Vascular aurantii 17, Fructus Aristolochiae 18, Rhizoma Gastrodiae 22, Radix Salviae Miltiorrhizae 20.
Embodiment 3
The present invention's (also claiming self-sufficient and strategically located region good for cardio-and cerebro-vessels capsule) prescription following (weight portion, down together):
Semen Ginkgo Rhizoma Corydalis complexing agent 44, Ganoderma extract 22, Ramulus Uncariae Cum Uncis 23, Radix Polygoni Multiflori 20, Radix Achyranthis Bidentatae 36, Rhizoma Chuanxiong 13, Herba Epimedii 22, Semen Cuscutae 20, Semen Cassiae 20, Fructus Gardeniae 20, Radix Et Rhizoma Rhei 10, Radix Aristolochiae 13, the Radix Angelicae Dahuricae 26, the Radix Paeoniae Alba 20, Radix Angelicae Sinensis 20, Haematitum 33, Poria 15, the Rhizoma Pinelliae 20, Radix Gentianae 4, Rhizoma Dioscoreae 28, Fructus Forsythiae 5, Flos Chrysanthemi 16, Pericarpium Citri Reticulatae 22, Cinnabaris 10, Radix Polygalae 20, Sargassum 30, Fructus Lycii 20, Magnetitum 23, Concha Haliotidis 23, Concha Margaritifera 20, the Fructus Sophorae 13, Radix Rehmanniae 25, Radix Scutellariae 20, the Cortex Eucommiae 20, Radix Scrophulariae 23, Spica Prunellae 26, Semen Ziziphi Spinosae 33 ， Herba Siegesbeckiaes 33, Semen Platycladi 20, Folium Mori 20, Rhizoma Polygonati 15, Fructus Ligustri Lucidi 13, Fructus Amomi Rotundus 18, Herba Leonuri 20, Mentholum 3, Borneolum Syntheticum 4, Radix Morindae Officinalis 20, Herba Taxilli 13, Herba Dendrobii 12, Fructus Rubi 10, Fructus Amomi 15, Cortex Moutan 7, Arisaema Cum Bile 18, Pulvis Cornus Bubali Concentratus 11, Rhizoma Cyperi 18, Concretio Silicea Bambusae 10, Pheretima 12, Vascular aurantii 15, Fructus Aristolochiae 16, Rhizoma Gastrodiae 20, Radix Salviae Miltiorrhizae 18.
In the above-mentioned prescription, the technical process that relevant raw material system is joined is as follows:
1, Semen Ginkgo Rhizoma Corydalis complexing agent
1) Folium Ginkgo: main chemical has flavonoid, terpenoid, polysaccharide, aminoacid, chlorophyll, colloid, tannin, cured matter, trace element etc.In the chemical constitution of flavonoid, have phenolic hydroxyl group, show acid, dissolve in the alkaline aqueous solution; And bilobalide has in alkali liquor its lactonic ring and can ftracture that to generate salt water-soluble, meet acid again Reclosable become the characteristic of original lactonic ring.In view of the above, this method with the Folium Ginkgo gathered before and after annual White Dew (flavones ingredient of Folium Ginkgo, northern area with April content the highest, take second place August, southern area then with May content the highest.Male plant is higher than female plant.Bilobalide is then opposite.So comprehensively decide, to pluck before and after White Dew to well, the Folium Ginkgo in this section period is ripe, decay gradually and wither, lose photosynthetic function, collection this moment does not promptly influence the growth of trees and views and admires, and can obtain active ingredient preferably again), through the washing drying, be ground into the fragment about 2mm, add PH=8-10 10 parts of sig waters (employing be lime liquor, because of ginkgetin can become to precipitate with calcium ion, be no more than 10 so pH value must strictly be controlled), soak and boil, stirred once, replenish sig water at any time every 10 minutes, keep PH=8,2 hours after-filtration time filtrate of winning.Filtering residue adds 8 parts of identical sig waters again, carry out same immersion and boil, 1.5 hours after-filtration, filtrate (its effective component content after, whether more further extract after measured by decision for filtering residue) for the second time.Merging filtrate, reduction vaporization are concentrated into 27 ° of Be ', add 95% ethanol, place the clarification after-filtration, and filtrate evaporated under reduced pressure reclaims ethanol to 27 ° Be ', adds 95% ethanol again, makes into 80% concentration of alcohol.Leave standstill the clarification after-filtration, filtrate evaporated under reduced pressure reclaims ethanol, not having ethanol to stock solution distinguishes the flavor of, add clear water to 27 ° Be ', impurity such as most aminoacid, chlorophyll, colloid, tannin, cured matter are removed, and the effective ingredient that is extracted is ginkgetin calcium, different ginkgetin calcium, bilobetin calcium, bilobalide calcium etc.Stand-by.
Ginkgetin and lime liquor reaction equation are as follows:
2(R-O-glu)+Ca(OH)
2→R-O-Ca-O-R+2glu-OH
R=ginkgo flavonoid glycoside base wherein;
Glu=glycosyl (as the D-glucosyl group);
2) Rhizoma Corydalis: the tuber that is Papaveraceae Herba corydalis edulis plant Rhizoma Corydalis.Tool promoting blood circulation to remove blood stasis, the effect of promoting the circulation of QI analgesic.Compendium of Material Medica record: Rhizoma Corydalis is specially controlled all over the body all pains up and down, with among simply fantastic." Chinese pharmacopoeia record: Rhizoma Corydalis acrid in the mouth, hardship, warm in nature, return liver, spleen channel.Function: invigorate blood circulation, promoting the circulation of QI, pain relieving.Be used for costa sternales, epigastric pain etc." Chinese medicine voluminous dictionary " recorded and narrated: Rhizoma Corydalis acrid in the mouth, hardship, and temperature, nontoxic.Return liver, stomach, spleen channel.Function: invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving." traditional Chinese medical science elite book series Chinese materia medica " record: Rhizoma Corydalis acrid in the mouth, hardship, temperature.Return liver, spleen channel.Pain relieving, invigorate blood circulation, promoting the circulation of QI.The stagnation of QI in the energy promoting the circulation of blood, stasis in the gas.Good analgesic effect is arranged, and tranquilizing soporific, spasmolysis are arranged.
Last century Chinese scholar from Rhizoma Corydalis, separate obtain 20 surplus an alkaloid monomer, practical proof great majority have intensive physiologically active.As: 13-Methylpalmatine has the effect of coronary artery dilator, and is very effective as treatment coronary heart disease clinically.
Alkaloid compound is elementary composition by C, H, O, N etc., the tool optical activity, and molecular weight is bigger.
According to each monomeric molecular structure, the valency electron hybrid orbital form of its nitrogen-atoms is SP
2And SP
3, alkalescence is stronger, be easy to acid combine the generation salt water-soluble.For this reason, the way that this programme adopts dilute sulfuric acid aqueous solution (concentration 65%) to extract makes it to generate alkaloid sulfate.Get through removing abiotic active impurity purification.As 13-Methylpalmatine and sulfuric acid reaction, its alkaloid cation and sulfate radical generate sulphuric acid Herba corydalis edulis alkali salt and organic acid.
Reaction equation is as follows: B+
2-acid
2-+ H
2SO
4→ B
2SO
4+ acid-H
2
Wherein, B=alkaloid cation+(as: 13-Methylpalmatine cation);
The acid=organic anion
2-(as: tartaric acid anion);
2, Semen Ginkgo Rhizoma Corydalis complexing agent: with ginkgetin calcium salt and the reaction of Rhizoma Corydalis alkaloid sulfate, generate calcium sulfate precipitation and Semen Ginkgo Rhizoma Corydalis complexing agent, concentrate through clarification filtration and separate out crystallization.
Reaction equation is as follows: B
2SO
4+ R-O-Ca-O-R → 2 (B-O-R)+CaSO
4
After the Semen Ginkgo Rhizoma Corydalis was compound, its molecule increased, and crystallization is thicker, easier separating out, and more convenient operation, its physiologically active is also stronger, and comprehensive therapeutic effect is better.
3, Ganoderma: contain ergosterol, mannitol, alkaloid, lactone, protein and multiple enzyme etc.Sweet in the mouth.Property is put down.Return the liver,spleen,kidney warp.Have bone and muscle strengthening, sharp joint, blood pressure lowering, blood fat reducing, the sensible effect of calming the nerves.
Ganoderma is the sporophore of Polyporaceae Ganoderma plant Ganoderma, and not clear and definite fully as yet because of its active ingredient, this programme is elected to be one of main component, also does the emphasis narration at this.Adopt the ethanol extraction of three kinds of concentration during extraction, be beneficial to the leaching of multiple components.
At first Ganoderma powder is broken into coarse powder, successively with 95%, 75%, 50% 3 kind of Different concentrations of alcohol dipping, each 24 hours, back clarification filtration, residue press dry clarification filtration, merges clear liquid, decompression recycling ethanol, to there not being the ethanol flavor, it is stand-by to add clear water to 27 ° Be '.
4, all the other are respectively distinguished the flavor of and are using Chinese medicine, and all according to the needs of prescription compatibility, with reference to above drug treating principle, purification is stand-by after refining respectively.Do not give unnecessary details in this.With reference to " Chinese pharmacopoeia is to the medicinal material processing general rule, and purification process is mixed after refining into 27 ° of Be ' concentrated solutions, continues to concentrate, dries, pulverizes.Be screened to 〉=100 orders in (or being spray dried to powder) medicinal hollow capsule of packing into and make.
The present invention adopts nourishing the kidney and liver, suppressing the hyperactive liver and subsiding YANG, invigorating the spleen and regulating the stomach, activating blood circulation, strengthening heart on Chinese prescription, the first series of measures of training of regulating the flow of vital energy, and fundamentally eliminating a disease reaches the effect for the treatment of both the principal and secondary aspects of a disease.
The present invention's (self-sufficient and strategically located region good for cardio-and cerebro-vessels capsule) testing result is as follows:
Table 1: organoleptic indicator
| Project | Index |
| Outward appearance | Yellowish-brown, uniform powder |
| Abnormal smells from the patient, flavour | Have medicated incense gas, little hardship, Hui Tian |
| Annotate: capsule body should meet national relevant requirements. | |
Table 2: physical and chemical index
| Project | Index |
| Flavone is qualitative | Positive |
| Moisture %≤ | 10.0 |
| Ash %≤ | 8.5 |
| Arsenic (in As) mg/kg≤ | 1.0 |
| Plumbous (in pb) mg/kg≤ | 1.5 |
| Hydrargyrum (in Hg) mg/kg≤ | 0.3 |
Table 3: microbiological indicator
| Project | Index |
| Total plate count cfu/g≤ | 1000 |
| Coliform MPN/100g≤ | 40 |
| Mycete cfu/g≤ | 25 |
| Yeast cfu/g≤ | 25 |
| Pathogenic bacterium (mean pathogenic entero becteria and pathogenic coccus | Must not detect |
The typical case of the present invention's (self-sufficient and strategically located region heart and brain heart recovering capsule) clinic trial is as follows:
Case 1: Wu * *, man, 25 years old
Medical history: dizziness, headache, tinnitus, insomnia 2 years, the time have nervous, heart beating, diet still can, it is relatively poor to sleep, constipation.Through examination in hospital, be diagnosed as hypertension, blood pressure continues at 130-140/90-110mmHg, hospitalization two months, blood pressure does not fall.Through examining.
Check: bodily form obesity, to have rosy cheeks, body of the tongue is slightly red, white and thin fur, arteries and veins is number slightly, blood pressure 140-100mmHg;
Dialectical: a little less than the deficiency of the kidney yin, overabundant liver-fire.
Method of treatment: nourishing the kidney for subduing the hyperactivity of liver-YANG, resolving heat and reducing pathogenic fire.
Take the good for cardio-and cerebro-vessels capsule, the 1st, 2 two day, obey two at every turn, day clothes 3 times rose on the 3rd day, obeyed 4 at every turn, day clothes 3 times.After taking 10 bottles, dizzy, headache obviously alleviates, and sleep takes a favorable turn, and it is not dry and hard to defecate, and blood pressure is reduced to 110/70mmHg.Body of the tongue, tongue fur are normal, stringy and thready pulse.Continue decrement later on and take medicine, keep blood pressure normal, all diseases are not sent out, and normally go up the worker always.
Case 2: once * *, man, 46 years old
Medical history: suffered from hypertension 5,6 years, often dizzy, dizzy, sleep is very poor, the time sense uncomfortable in chest, breathe hard, the disposition agitation, emotional, feeling of numbness is arranged during left cheek.Blood pressure continues at 160/120-130mmHg, and it is invalid once to obey multiple depressor.
Check: the dim red weary pool of complexion, body of the tongue is light red, tongue is white, stringy and thready pulse, face is edema slightly.
Dialectical: the hepatic and renal YIN deficiency, liver-fire is vigorous, retention of phlegm-heat in the interior.
Method of treatment: nourishing the liver and kidney, suppressing the hyperactive liver pathogenic fire reducing, removing heat-phlegm.
Method of administration the 1st day is obeyed 1 at every turn, every day 3 times.Rose in the 2nd day, and obeyed 3 at every turn, obey every day 3 times, have no adverse reaction, rose in per 4 days, obey 4, every day 3 times at every turn.After taking 10 bottles, the sensation sleep takes a turn for the better, and brains is salubriouser, and blood pressure 150/110mmHg spirit is preferable.Continue after three months, to take medicine 40 bottles as before taking medicine altogether, blood pressure stabilization is at 140/90mmHg, and it is good greatly to sleep, and diseases such as dizziness, headache, agitation disappear, and edema disappears entirely, and mood is good greatly, and is working properly.
Case 3, open * *, woman, 55 years old.
Medical history: hypertension 3 years, often continue 160/100mmHg, be up to 210/130mmHg.The time dizziness is arranged, tinnitus, heart beating, insomnia, dreaminess, agitation, emotional, the vexed plug of upper abdomen is not smooth sometimes, bitter taste is dull, the bipod edema.The cholesterol 232mg% that has a blood test is diagnosed as high fat of blood, hypertension.
Check: fat, two cheekbones are reddish brown, red tongue, yellow and thin fur, stringy and tense pulse.Blood pressure 160/110mmHg.
Method of treatment: nourishing kidney is nourished heart, the liver heat removing YANG hyperactivity suppressing, and assistant is with soothing liver and strengthening spleen.
Method of administration: 1st, 2 two days, at every turn obey two, day clothes 3 times, 4 of each later on clothes, day clothes 3 times.Take medicine after 20 bottles, dizzyly, nervous take a turn for the better to some extent, still sense is irritated, tinnitus, and xerostomia, diet is not good.Thin white fur of tongue, the pulse classic stringy and thready pulse, the foot edema fades.Continue as before take medicine after 10 bottles, blood pressure is normal at ordinary times, and during the overstrain work strain, blood pressure slightly raises.Felt behind the clothes to 40 bottle that aforementioned shape disappears, blood pressure is normal.
Case 4: Liu * *, man, 54 years old.
Medical history: often giddy, dizziness, head distension syndrome, insomnia, dreaminess be year surplus in the of ten.Find that blood pressure increases over nearly 3 years, generally continue to be up to 190/120mmHg, do not imitate with the depressor treatment at 160-170/100-110mmHg.The heating of chronognosis nostril, nervous, to breathe hard, the root of the tongue hardens, and nocturia is frequency slightly, and diet is dull, constipation with dry stool, examination in hospital is diagnosed as hypertension, arteriosclerosis.
Check: the bodily form is more fat, and complexion is dim red, and body of the tongue is slightly red, white and thin fur, stringy pulse.
Dialectical: the hepatic and renal YIN deficiency, liver-fire is vigorous, a little less than the heart is insufficiency of the spleen.
Method of treatment: enriching yin and nourishing kidney, the suppressing the hyperactive liver pathogenic fire reducing, assistant is good for the stomach to nourish heart.
The 1st day, obey two of capsules at every turn, day clothes 3 times have no adverse reaction, and rise in the 2nd day, obey 4 at every turn, day clothes 3 times.Take medicine after 30 bottles, dizziness, headache obviously alleviates, and sleep takes a favorable turn, and all the other symptoms all have and alleviate, and blood pressure gradually drops to 140/90mmHg.
The symptom of a trend of original patient's condition appears again in one week of drug withdrawal, but adheres to working always, by 3 of each clothes, continues to take medicine again.After, under the unusual or situation influence that is busy with one's work, health does not have uncomfortable sensation at loss of emotion, and blood pressure is normal always.
Case 5: blue * *, the man, 48 years old medical history: blood pressure is higher, and frequent headache, dizziness be the several years, and there are anaphora and the dancing sensation of blood vessel in two temples, and the eyeball distending pain keeps in dark place, and it is bad to sleep, dreaminess, agitation, hypomnesis.Two big toes and right hand forefinger numbness have edema slightly.
Check: of medium height, body is slightly fat, red tip of the tongue, white and thin fur, pulse condition stringy and thready pulse, blood pressure 172/120mmHg.
Dialectical: deficiency of kidney-YIN, the high Sheng of liver-yang.
Method of treatment: nourishing kidney liver heat removing, tranquilizing by nourishing the heart.
Method of administration, initial the 1st day, take medicine 4 at every turn, day clothes 3 times, it is uncomfortable slightly to feel stomach, is kept to 2 of each clothes, and respectively obeys 1 time ante cibum sooner or later in the 2nd day.Have no adverse reaction, sleep take a favorable turn slightly.Rose in the 4th day, and be increased to 3 of each clothes, day clothes 3 times, take 25 bottles after, headache disappears, dizziness subtracts greatly, sleep is better, appetite is cumulative, the highest 160/100mmHg of blood pressure.
Continue later on by 3 of each clothes, day clothes 3 times, take medicine ante cibum.Adhere to operate as normal always.
Claims (7)
1. a medicine for the treatment of cardiovascular disease is characterized in that, it is the medicament of being made by the following weight proportion raw material:
Semen Ginkgo Rhizoma Corydalis complexing agent 42-46, Ganoderma extract 20-24, Ramulus Uncariae Cum Uncis 21-24, Radix Polygoni Multiflori 18-22, Radix Achyranthis Bidentatae 34-38, Rhizoma Chuanxiong 11-14, Herba Epimedii 20-24, Semen Cuscutae 18-22, Semen Cassiae 18-22, Fructus Gardeniae 18-22, Radix Et Rhizoma Rhei 8-12, Radix Aristolochiae 11-14, Radix Angelicae Dahuricae 24-28, Radix Paeoniae Alba 18-22, Radix Angelicae Sinensis 18-22, Haematitum 31-34, Poria 13-17, Rhizoma Pinelliae 18-22, Radix Gentianae 3-5, Rhizoma Dioscoreae 26-30, Fructus Forsythiae 4-6, Flos Chrysanthemi 14-18, Pericarpium Citri Reticulatae 20-24, Cinnabaris 9-11, Radix Polygalae 18-22, Sargassum 28-32, Fructus Lycii 18-22, Magnetitum 21-25, Concha Haliotidis 21-25, Concha Margaritifera 18-22, Fructus Sophorae 12-14, Radix Rehmanniae 23-27, Radix Scutellariae 18-22, Cortex Eucommiae 18-22, Radix Scrophulariae 21-25, Spica Prunellae 24-28, Semen Ziziphi Spinosae 31-35
Herba Siegesbeckiae 31-35, Semen Platycladi 18-22, Folium Mori 18-22, Rhizoma Polygonati 13-17, Fructus Ligustri Lucidi 11-15, Fructus Amomi Rotundus 16-20, Herba Leonuri 24-28, Mentholum 2-4, Borneolum Syntheticum 3-5, Radix Morindae Officinalis 18-22, Herba Taxilli 11-15, Herba Dendrobii 10-14, Fructus Rubi 8-12, Fructus Amomi 13-17, Cortex Moutan 6-8, Arisaema Cum Bile 16-20, Pulvis Cornus Bubali Concentratus 10-12, Rhizoma Cyperi 16-20, Concretio Silicea Bambusae 8-12, Pheretima 10-14, Vascular aurantii 13-17, Fructus Aristolochiae 14-18, Rhizoma Gastrodiae 18-22, Radix Salviae Miltiorrhizae 16-20;
Said Semen Ginkgo Rhizoma Corydalis complexing agent be with Folium Ginkgo through the product of the extract of lime liquor and Rhizoma Corydalis and dilute sulfuric acid reaction mix mutually chemical reaction takes place after, remove the resulting product of calcium sulfate.
2. medicine according to claim 1 is characterized in that, wherein the weight proportion of each raw material is:
Semen Ginkgo Rhizoma Corydalis complexing agent 42, Ganoderma extract 20, Ramulus Uncariae Cum Uncis 21, Radix Polygoni Multiflori 18, Radix Achyranthis Bidentatae 34, Rhizoma Chuanxiong 11, Herba Epimedii 20, Semen Cuscutae 18, Semen Cassiae 18, Fructus Gardeniae 18, Radix Et Rhizoma Rhei 8, Radix Aristolochiae 11, the Radix Angelicae Dahuricae 24, the Radix Paeoniae Alba 18, Radix Angelicae Sinensis 18, Haematitum 31, Poria 13, the Rhizoma Pinelliae 18, Radix Gentianae 3, Rhizoma Dioscoreae 26, Fructus Forsythiae 4, Flos Chrysanthemi 14, Pericarpium Citri Reticulatae 20, Cinnabaris 9, Radix Polygalae 18, Sargassum 28, Fructus Lycii 18, Magnetitum 21, Concha Haliotidis 21, Concha Margaritifera 18, the Fructus Sophorae 12, Radix Rehmanniae 23, Radix Scutellariae 18, the Cortex Eucommiae 18, Radix Scrophulariae 21, Spica Prunellae 24, Semen Ziziphi Spinosae 31
Herba Siegesbeckiae 31, Semen Platycladi 18, Folium Mori 18, Rhizoma Polygonati 13, Fructus Ligustri Lucidi 11, Fructus Amomi Rotundus 16, Herba Leonuri 24, Mentholum 2, Borneolum Syntheticum 3, Radix Morindae Officinalis 18, Herba Taxilli 11, Herba Dendrobii 10, Fructus Rubi 8, Fructus Amomi 13, Cortex Moutan 6, Arisaema Cum Bile 16, Pulvis Cornus Bubali Concentratus 10, Rhizoma Cyperi 16, Concretio Silicea Bambusae 8, Pheretima 10, Vascular aurantii 13, Fructus Aristolochiae 14, Rhizoma Gastrodiae 18, Radix Salviae Miltiorrhizae 16.
3. medicine according to claim 1 is characterized in that, wherein the weight proportion of each raw material is:
Semen Ginkgo Rhizoma Corydalis complexing agent 46, Ganoderma extract 24, Ramulus Uncariae Cum Uncis 24, Radix Polygoni Multiflori 22, Radix Achyranthis Bidentatae 38, Rhizoma Chuanxiong 14, Herba Epimedii 24, Semen Cuscutae 22, Semen Cassiae 22, Fructus Gardeniae 22, Radix Et Rhizoma Rhei 12, Radix Aristolochiae 14, the Radix Angelicae Dahuricae 28, the Radix Paeoniae Alba 22, Radix Angelicae Sinensis 22, Haematitum 34, Poria 17, the Rhizoma Pinelliae 22, Radix Gentianae 5, Rhizoma Dioscoreae 30, Fructus Forsythiae 6, Flos Chrysanthemi 18, Pericarpium Citri Reticulatae 24, Cinnabaris 11, Radix Polygalae 22, Sargassum 32, Fructus Lycii 22, Magnetitum 25, Concha Haliotidis 25, Concha Margaritifera 22, the Fructus Sophorae 14, Radix Rehmanniae 27, Radix Scutellariae 22, the Cortex Eucommiae 22, Radix Scrophulariae 25, Spica Prunellae 28, Semen Ziziphi Spinosae 35, Herba Siegesbeckiae 35, Semen Platycladi 22, Folium Mori 22, Rhizoma Polygonati 17, Fructus Ligustri Lucidi 15, Fructus Amomi Rotundus 20, Herba Leonuri 28, Mentholum 4, Borneolum Syntheticum 5, Radix Morindae Officinalis 22, Herba Taxilli 15, Herba Dendrobii 14, Fructus Rubi 12, Fructus Amomi 17, Cortex Moutan 8, Arisaema Cum Bile 20, Pulvis Cornus Bubali Concentratus 12, Rhizoma Cyperi 20, Concretio Silicea Bambusae 12, Pheretima 14, Vascular aurantii 17, Fructus Aristolochiae 18, Rhizoma Gastrodiae 22, Radix Salviae Miltiorrhizae 20.
4. medicine according to claim 1 is characterized in that, wherein the weight proportion of each raw material is:
Semen Ginkgo Rhizoma Corydalis complexing agent 44, Ganoderma extract 22, Ramulus Uncariae Cum Uncis 23, Radix Polygoni Multiflori 20, Radix Achyranthis Bidentatae 36, Rhizoma Chuanxiong 13, Herba Epimedii 22, Semen Cuscutae 20, Semen Cassiae 20, Fructus Gardeniae 20, Radix Et Rhizoma Rhei 10, Radix Aristolochiae 13, the Radix Angelicae Dahuricae 26, the Radix Paeoniae Alba 20, Radix Angelicae Sinensis 20, Haematitum 33, Poria 15, the Rhizoma Pinelliae 20, Radix Gentianae 4, Rhizoma Dioscoreae 28, Fructus Forsythiae 5, Flos Chrysanthemi 16, Pericarpium Citri Reticulatae 22, Cinnabaris 10, Radix Polygalae 20, Sargassum 30, Fructus Lycii 20, Magnetitum 23, Concha Haliotidis 23, Concha Margaritifera 20, the Fructus Sophorae 13, Radix Rehmanniae 25, Radix Scutellariae 20, the Cortex Eucommiae 20, Radix Scrophulariae 23, Spica Prunellae 26, Semen Ziziphi Spinosae 33, Herba Siegesbeckiae 33, Semen Platycladi 20, Folium Mori 20, Rhizoma Polygonati 15, Fructus Ligustri Lucidi 13, Fructus Amomi Rotundus 18, Herba Leonuri 20, Mentholum 3, Borneolum Syntheticum 4, Radix Morindae Officinalis 20, Herba Taxilli 13, Herba Dendrobii 12, Fructus Rubi 10, Fructus Amomi 15, Cortex Moutan 7, Arisaema Cum Bile 18, Pulvis Cornus Bubali Concentratus 11, Rhizoma Cyperi 18, Concretio Silicea Bambusae 10, Pheretima 12, Vascular aurantii 15, Fructus Aristolochiae 16, Rhizoma Gastrodiae 20, Radix Salviae Miltiorrhizae 18.
5. according to claim 1 or 2 or 3 or 4 described medicines, it is characterized in that said medicament is a said peroral dosage form on any pharmaceutics.
6. medicine according to claim 5 is characterized in that said medicament is a capsule.
7. according to the preparation method of the described Semen Ginkgo Rhizoma Corydalis of claim 1 complexing agent; It is characterized in that, carry out according to the following steps:
A) preparation of Folium Ginkgo extract
1 part of Folium Ginkgo is ground into the fragment about 2mm after the washing drying, 10 parts of the lime liquors of adding PH=8-10 soak and boil 2 hours, filter time filtrate of winning; Filtering residue adds 8 parts of identical lime liquors again, soaks to boil 1.5 hours, filter filtrate for the second time; Merge gained filtrate twice, and reduction vaporization to 27 ° Be ', after ethanol is removed impurity, and with after the recovery of ethanol reduction vaporization, the Folium Ginkgo extract that makes 27 ° of Be ' is standby;
B) Rhizoma Corydalis is broken for powdery, and adds dilute sulfuric acid, soak the solution that obtains Rhizoma Corydalis alkaloid sulfate;
C) solution of Folium Ginkgo extract with Rhizoma Corydalis alkaloid sulfate is mixed, after the reaction, remove calcium sulfate after filtration, concentrate, crystallization makes this complexing agent.
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| CN101002791B (en) * | 2007-01-23 | 2010-04-07 | 胡传良 | Traditional Chinese medicine composition for treating cerebrovascular disease, and its preparing method |
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| CN101347557B (en) * | 2008-08-14 | 2010-12-08 | 于宝锋 | Medicament composition for refreshment and intelligence development and preparation and use thereof |
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| CN102343059B (en) * | 2010-07-30 | 2013-04-03 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition with effect of strengthening spleen to promote digestion for livestock and poultry and preparation method thereof |
| CN101897896B (en) * | 2010-08-04 | 2012-05-23 | 北京科莱博医药开发有限责任公司 | Traditional Chinese medicine composition for treating cataract, pharmaceutical preparation thereof and preparation method thereof |
| CN103251829B (en) * | 2013-05-15 | 2015-04-01 | 广州药灸堂生物科技有限公司番禺分公司 | Chinese herbal medicine formula ointment for treating hypertension and preparation method thereof |
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| CN103549829A (en) * | 2013-11-15 | 2014-02-05 | 黄翠萍 | Traditional Chinese medicine pillow for treating cerebral thrombosis |
| CN103654035B (en) * | 2013-11-25 | 2016-02-03 | 李质玉 | A kind of blood pressure-reducing pillow antihypertensive drugs and preparation method thereof |
| CN103623248B (en) * | 2013-11-29 | 2015-04-29 | 高鑫 | Traditional Chinese medicinal composition for reducing blood pressure |
| CN103816402A (en) * | 2014-03-25 | 2014-05-28 | 梁黎明 | Traditional Chinese medicine composition for treating liver wind agitation |
| CN117959387B (en) * | 2024-02-08 | 2024-06-18 | 湖南中医药大学 | Traditional Chinese medicine composition for treating hypertension, preparation method and application |
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