CN103599062B - A kind of eye cream and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of eye cream and preparation method thereof, eye cream lotion exquisiteness of the present invention, color and luster is even, smell is pure. This product is on antioxidant network system basis, add poly-polysaccharide Firm agent, beta glucan, hyaluronic acid, resveratrol isoreactivity composition, and the multiple Chinese herbal medicine extract such as composite frankincense, Poria cocos, rhodiola root, there is stronger anti-oxidant, moisturizing and the effect of compacting. Various active composition cooperatively interacts, Synergistic, can improve eye wrinkle-removing, Vitamin K, the profile near the eyes that compacts, and it is color that the two pupils of order recover radiating power and vitality god.

Description

A kind of eye cream and preparation method thereof

technical field

The invention mainly relates to an eye cream and belongs to the field of cosmetics.

Background technique

Skin aging is the result of the joint action of endogenous and exogenous factors. Among them, the highly chemically active free radicals produced in the body's metabolic process are important initiating factors of aging. Free radicals are asymmetric and unstable atoms or molecules formed by losing an electron. They have great energy and can attack lipids, proteins, sugars, DNA and other substances in cell tissues in an attempt to capture an electron. In order to achieve rebalancing, this causes the oxidation of lipids and sugars, denaturation of proteins, inactivation of enzymes, cutting of DNA structures, changes in bases, etc., resulting in damage to cell membranes, genetic factors, etc., and then induces Various diseases, cancer, body aging, etc. Exogenous factors such as long-term exposure to ultraviolet rays, environmental pollution, and cigarette smoke will also generate a large number of free radicals, leading to skin aging.

Antioxidants can achieve the purpose of anti-oxidation by inhibiting the generation of free radicals or scavenging and trapping free radicals, interrupting the chain reaction of free radicals. According to its chemical structure, it can be divided into enzymatic and non-enzymatic antioxidants. Enzymatic antioxidants include superoxide dismutase (SOD), catalase, coenzyme Q10 (CoQ10) and DNA/RNA repair enzymes, etc.; non-enzymatic Antioxidants such as vitamin A (VA), vitamin C (VC), vitamin E (VE), β-carotene, α-lipoic acid (LA), glutathione (GSH), zinc, selenium and other substances. Antioxidants are used in cosmetics, which can not only inhibit the oxidative deterioration of active substances and nutrients in the air through bacterial invasion or photocatalysis, but also work together with other active ingredients in cosmetics to moisturize, wrinkle, and anti-aging. effects of aging.

Studies have found that the antioxidant activity of some composite antioxidants is higher than the sum of the activities of each component at the added concentration, that is, the combined use of multiple antioxidants is often greater than the effect of a single antioxidant at the same dose. Antioxidant components often have antioxidative synergistic effects, and the synergistic effect is affected by the concentration of antioxidants and the reaction system. Scholars such as Dr. Lest Paker, a famous professor at the University of California, Berkeley, and chairman of the International Free Radical Society, proposed the free radical scavenger chain reaction and antioxidant network technology, and clearly compared them to the latest modern and efficient anti-aging models. In this antioxidant system or antioxidant network, VC, VE, CoQ10, LA, and GSH are proposed as the core and essence of antioxidant network technology. The main reasons are as follows: First, the body cannot produce VC and VE, and must be obtained from food Second, although the body can produce GSH, LA and CoQ10 by itself, their levels in the body decrease significantly with age; third, these five antioxidants have broad-spectrum and high-efficiency free radical scavenging capabilities, and They can complement and synergize each other; fourth, network free radical scavengers or network antioxidants have their own unique effects that are different from other free radical scavengers or antioxidants; fifth, the five network free radicals in the body Radical scavengers or network antioxidants interact and can regenerate each other, allowing each other to recirculate, forming a network that greatly enhances the function of antioxidants. This network is mediated by free radicals in biological systems The main line of defense against toxic damage ultimately plays a special role in the process of delaying aging and improving the body's resistance to disease.

Antioxidant chain reaction and antioxidative network technology has become a very popular and innovative modern mode of antioxidation and antiaging in the world. According to this network technology and model, various types of skin anti-aging cosmetics can be developed, and the five antioxidant networks will definitely play an active role and complement each other in the use of anti-aging cosmetics, making the skin anti-aging more effective. Obvious features, produce more significant effect.

Eyes are the windows to the soul, and they are the most revealing of a woman's age. As we age, the skin around the eyes suffers more than any other part of the face. The eye skin is thin, with low fat content, lack of elastic fibers and collagen structure, and frequent blinking will make the eye skin constantly stretched; coupled with irregular life and rest, improper use of eyes, etc., can easily cause eye skin to be dull, If the skin is loose, problems such as dark circles, bags under the eyes, and crow's feet will appear, and those with dry skin are more prone to the above-mentioned signs of aging. Eye cream is mainly designed for people with dry skin. It is more refreshing and delicate than face cream. It is easy to be absorbed by the eye skin and can properly replenish oil. It has the effects of moisturizing, moisturizing, and smoothing fine lines.

At present, there are many kinds of eye creams on the market, but there are no commercial products that combine Chinese herbal medicine extracts and antioxidant network systems into eye creams. Guided by the anti-oxidation network system theory and emulsification theory, the present invention compounded a variety of additives with anti-oxidation activity and Chinese herbal medicine extracts, and added high-efficiency moisturizing agents and skin-firming agents at the same time to develop a moisturizing, anti-wrinkle, and firming agent. and other multi-functional eye creams; at the same time, the sensory and physical and chemical indicators, moisturizing properties, antioxidant properties, and anti-wrinkle and firming effects on the skin around the eyes of the eye cream were tested.

Contents of the invention

The object of the present invention is to provide an eye cream and a preparation method thereof.

The present invention is achieved through the following technical solutions:

A kind of eye cream, it is characterized in that the prescription of described eye cream is:

Preparation method of eye cream:

Put phase A and phase B in a water bath at 70-75°C and stir for 25-30 minutes to dissolve the solids, then add the dissolved phase F to phase A to disperse evenly, and then dissolve phase B while stirring Add phases; stir rapidly for 25-30 minutes and then cool down. When cooled to 40-45°C, add phase C, phase D and phase E respectively and stir until uniform. When the temperature drops to 30-35°C, stop stirring and discharge to obtain The eye cream.

The invention relates to a method for preparing an eye cream. In order to keep the total amount of the finished product at 100 g during the preparation process, an appropriate amount of distilled water is added while adding each phase.

The advantages of the present invention are:

The eye cream of the present invention uses siloxanes, synthetic squalane, caprylic acid/capric triglyceride, etc. as oil phase raw materials, which are moist, smooth, and breathable, and give the skin around the eyes a silky feeling; Sodium hyaluronate, panthenol and oat β-glucan and other substances can instantly restore the skin's moisturizing and barrier functions, balance and regulate the skin's internal water circulation and improve rough skin texture; centered on the antioxidant network system, the compound Rhodiola rosea extract, resveratrol and other active antioxidants have broad-spectrum and high-efficiency free radical scavenging capabilities, and can synergize, regenerate each other, and recycle each other, greatly enhancing the antioxidant capacity. function; polysaccharide firming agent inhibits eye relaxation, makes eye skin firm and firm, and at the same time has the effect of improving resistance, promoting cell growth, and anti-inflammation; Poria cocos extract can reduce edema and brighten the eye area; frankincense extract Herbs have the functions of promoting blood circulation, anti-inflammation, removing dark circles and firming the skin; Astragalus extract can promote the synthesis of collagen; Angelica extract can promote blood circulation and remove blood stasis, and has the effect of preventing and removing dark circles.

The eye cream ointment of the present invention is fine and smooth, and color and luster are uniform. Some active ingredients adopt nanoemulsion, liposome and microcapsule technology, which not only facilitates the transmission of active ingredients and skin absorption, but also increases the stability of the product. The formula does not contain alcohol, fragrance, and parabens, and is mild and non-irritating. A variety of active ingredients cooperate with each other and synergistically, which can improve eye wrinkles, dilute dark circles, tighten the contours of the eyes, and restore the radiance of the eyes.

Description of drawings

Fig. 1 is the photomicrograph (×400) of eye cream sample of the present invention;

Fig. 2 is the relationship diagram of the moisture absorption rate of eye cream as a function of time;

Figure 3 is the comparison photos before and after the tester used the eye cream for 30 minutes, (a) before use; (b) after 15 minutes of use; (c) after 30 minutes of use.

Figure 4 is a comparison chart of the skin conditions around the eyes of two subjects aged 42 and 26 years old with dry skin before use and after 90 days of use, (a) is before use by a 42-year-old trial person; (b) After 90 days of use by a 42-year-old trial person; (c) before use by a 26-year-old trial person; (d) after 90 days of use by a 26-year-old trial person.

detailed description

Example 1

A kind of eye cream, it is characterized in that the prescription of described eye cream is:

A preparation method of eye cream, comprising the following steps:

Put phase A and phase B in a water bath at 70-75°C and stir for 25-30 minutes to dissolve the solids, then add the dissolved phase F to phase A to disperse evenly, and then dissolve phase B while stirring phase join;

After rapid stirring for 25-30 minutes, cool down. When cooled to 40-45°C, add phase C, phase D, and phase E respectively and stir until uniform. When the temperature drops to 30-35°C, stop stirring and discharge to obtain the eye cream. .

Performance Testing:

Granularity test

Take a small amount of eye cream sample on a glass slide, cover it with a cover glass, roll it evenly, put it under a microscope to observe and take pictures. The microscope magnification is 400 times.

Antioxidant test

Weigh 0.5g of eye cream, dissolve it in pure water, transfer it to a 100mL volumetric flask, and prepare a sample solution with a mass concentration of 5.00×10 ^-3 g/mL.

Prepare the absolute ethanol solution of DPPH with a concentration of 2×10 ^-4 g/mL, the absolute ethanol solution with a concentration of 10mmol/L salicylic acid, the aqueous solution of FeSO ₄ with a concentration of 10mmol/L, and a concentration of 8.8mmol/L H ₂ O ₂ aqueous solution, a Tris-HCl buffer solution with a pH of 8.2, a HCl solution with a concentration of 10mmol/L, and a pyrogallol solution with a concentration of 5mmol/L (the HCl solution with a concentration of 10mmol/L is used as a solvent) .

(1) Test of the inhibition rate of DPPH free radicals

Pipette 3mL of the sample solution to be tested into a 10mL volumetric flask, and then add 3mL of DPPH solution with a concentration of 2×10 ^-4 g/mL. Cover the stopper, shake well, react for 30 minutes, measure the absorbance A _i at 517nm; measure the absorbance A _j of the mixture of 3mL sample solution and 3mL ethanol; measure the concentration of 3mL 2×10 ^-4 g/mLDPPH solution mixed with 3mL pure water After absorbance A ₀ . According to the formula P=[1-(A _i -A _j )/A ₀ ]×100%, the measured absorbance is brought into to obtain the inhibition rate of the test solution on DPPH·free radicals.

(2) Test of the inhibition rate of OH free radicals

Add 2mL of 10mmol/L salicylic _acid solution and 10mmol/L _FeSO4 solution to a 10mL volumetric flask, then add 2mL of the test solution, then add 2mL of H2O2 solution with a concentration of _8.8mmol /L, shake After homogenization, react in a 37°C water bath for 30 minutes. Measure the absorbance A _i at 510nm; measure the absorbance A _j with 2mL pure water instead of H ₂ O ₂ ; measure the absorbance A ₀ with 2mL pure water instead of the test solution. According to the formula P=[1-(A _i -A _j )/A ₀ ]×100%, the measured absorbance is taken into the test solution to obtain the inhibition rate of OH free radicals.

(3) Test of the inhibition rate of O ₂ ^-free radicals

Take 5 mL of Tris-HCl buffer solution with a pH of 8.2 in a 10 mL volumetric flask, preheat it in a 25°C water bath for 20 min, then add 2 mL of the test solution and 0.5 mL of pyrogallol solution at 5 mmol/L in sequence, and shake well immediately. React in a water bath at 25°C for 4 minutes, and immediately measure the absorbance A _i at 320nm; replace pyrogallol with 0.5mL of 10mmol/L HCl solution, and measure the absorbance _Aj ; use 2mL pure water instead of the test solution to measure the absorbance A ₀ . According to the formula P=[1-(A _i -A _j )/A ₀ ]×100%, the measured absorbance is taken into account to obtain the inhibition rate of the test solution on ·O ₂ ^-free radicals.

Moisture Absorption Test

Weigh 5g of the eye cream sample and place it in a weighing bottle, place it in an environment of (20±1)°C and a relative humidity of 43% and 75%, take it out and weigh it every 1h, up to 8h. Calculate the moisture absorption rate according to the following formula.

Among them, m _n is the mass of the sample after being placed for n hours, g; m ₀ is the mass of the sample to be tested before being placed, in g.

Sensory performance evaluation

The prepared eye cream is visually observed at room temperature and under non-direct sunlight to see whether the paste is fine and smooth, whether the color is uniform, and whether the smell is pure or not is identified by the sense of smell.

pH test

Weigh 3.0g of the sample, put it into a small beaker filled with 30.0mL of deionized water to remove _CO2 , heat to 40±1°C with constant stirring, and measure it with a calibrated pH meter after cooling to room temperature.

High and low temperature experiments

Put the sample into a sealed plastic box, and place it in a constant temperature oven at 40°C and in a freezer at -10°C for 24 hours, take it out and return it to room temperature, and observe whether there is oil-water separation or obvious difference in properties.

efficacy test

Select 20 people as testers, the average age is 35 years old, most of them have dry and dehydrated skin. The subjects applied eye cream around the eyes after cleansing every morning and evening for a total of 90 days, and tested their skin condition with a skin tester every 15 days. And the eyes of several subjects were photographed before using the eye cream and after 15 minutes and 30 minutes.

Test Results

Emulsion particle test results

It can be seen from Figure 1 that the particles of the eye cream sample are small and evenly dispersed, indicating that the emulsification effect is good. Usually, under the premise of fixing the emulsifier and adjusting the ratio of glycerin, butanediol and pentylene glycol to 4:2:1, the particle size of the dispersed phase of the prepared eye cream is the most uniform, and the paste is the most delicate.

Antioxidant Test Results

The inhibitory rate of table 2 eye cream solution to 3 kinds of free radicals

free radical DPPH· ·OH ·O ₂ ^- Inhibition rate 84.9% 63.6% 53.6%

Table 2 is the inhibition rate of eye cream solution to 3 kinds of free radicals. It can be seen that when the concentration is 5.00×10 ^-3 g/mL, the inhibition rate of the eye cream solution to DPPH·, ·OH and ·O ₂ ^-3 free radicals reached 84.9%, 63.6% and 53.6%, respectively, indicating that this Invented eye cream has strong antioxidant capacity and can effectively scavenge free radicals. The strong antioxidant capacity is mainly obtained by compounding the antioxidant network system with resveratrol, frankincense extract, rhodiola extract, etc.

Moisture Performance Analysis

Taking time as the abscissa and the moisture absorption rate as the ordinate, the relationship diagram of the moisture absorption rate of the eye cream sample with time is shown in Figure 2. It can be seen from the figure that the moisture absorption rate is negative, indicating that the samples will lose water if they are left for a long time; however, since a variety of humectants are added to the samples, they should be placed in environments with relative humidity of 75% and 43% at 20°C After 8 hours, the moisture absorption rates were -1.04% and -1.15%, respectively, and the water loss was very slow, indicating that the eye cream has a good moisturizing ability.

Sensory and physical and chemical test results

Table 3 Sensory and physical and chemical index test results

The test results in Table 3 show that the sensory and physical and chemical indicators of the eye cream of the present invention all meet the standard requirements of my country's cosmetics industry.

Analysis of Trial Results

Figure 3 is a photo comparison of the skin around the eyes of a 55-year-old tester with dry skin before using the eye cream and after 15 minutes and 30 minutes. It can be seen from the figure that the lines of the skin around the eyes are deep and the wrinkles are obvious before use; after using the eye cream of the present invention for 15 minutes, the wrinkles are obviously lighter, and the subject can obviously feel the skin lifting feeling; after 30 minutes of use, the skin The lines continued to lighten, and the subject could still feel the lifting effect.

Figure 4 is a comparison of the skin conditions around the eyes of two subjects aged 42 and 26 years old with dry skin before use and after 90 days of use. The changes in various indicators of the skin around the eyes are shown in Table 4. It can be seen that after using the eye cream continuously for 90 days, the texture of the skin around the eyes becomes significantly lighter, the problems of dehydration and dull skin around the eyes are improved, and the contours of the eyes become firmer.

Table 4 Changes in various indicators of the skin around the eyes before and after using the eye cream for 90 days

.

Claims (3)

1. an eye cream, characterized in that the formula of said eye cream is: . 2. a preparation method of eye cream as claimed in claim 1, is characterized in that comprising the following steps: Put phase A and phase B in a water bath at 70-75°C and stir for 25-30 minutes to dissolve the solids, then add the dissolved phase F to phase A to disperse evenly, and then dissolve phase B while stirring Add phases; stir rapidly for 25-30 minutes and then cool down. When cooled to 40-45°C, add phase C, phase D and phase E respectively and stir until uniform. When the temperature drops to 30-35°C, stop stirring and discharge to obtain The eye cream. 3. The preparation method of a kind of eye cream according to claim 2, is characterized in that in the preparation process, for making the finished product total amount remains 100g, when adding each phase, add appropriate amount of distilled water again.