CN103550102A - Chinese herbal medicine toothpaste containing radix notoginseng total saponins and lignum vitae sodium azulenesulfonate - Google Patents
Chinese herbal medicine toothpaste containing radix notoginseng total saponins and lignum vitae sodium azulenesulfonate Download PDFInfo
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- CN103550102A CN103550102A CN201310546261.9A CN201310546261A CN103550102A CN 103550102 A CN103550102 A CN 103550102A CN 201310546261 A CN201310546261 A CN 201310546261A CN 103550102 A CN103550102 A CN 103550102A
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- Prior art keywords
- radix notoginseng
- total saponins
- notoginseng total
- sodium
- kessazulen
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- 235000003143 Panax notoginseng Nutrition 0.000 title claims abstract description 52
- 241000180649 Panax notoginseng Species 0.000 title claims abstract description 52
- 229930182490 saponin Natural products 0.000 title claims abstract description 51
- 150000007949 saponins Chemical class 0.000 title claims abstract description 51
- 235000017709 saponins Nutrition 0.000 title claims abstract description 51
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 29
- 239000000606 toothpaste Substances 0.000 title claims abstract description 29
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 title abstract description 7
- 241000190019 Guaiacum Species 0.000 title abstract 5
- 235000004440 Guaiacum sanctum Nutrition 0.000 title abstract 5
- 241000411851 herbal medicine Species 0.000 title abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 68
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 34
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 28
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 20
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 20
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 20
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 19
- 239000000600 sorbitol Substances 0.000 claims abstract description 19
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical group OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims abstract description 17
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 17
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 17
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 239000000679 carrageenan Substances 0.000 claims abstract description 9
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 9
- 229920001525 carrageenan Polymers 0.000 claims abstract description 9
- 229940113118 carrageenan Drugs 0.000 claims abstract description 9
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 9
- 229920002907 Guar gum Polymers 0.000 claims abstract description 8
- 239000011230 binding agent Substances 0.000 claims abstract description 8
- 239000000665 guar gum Substances 0.000 claims abstract description 8
- 235000010417 guar gum Nutrition 0.000 claims abstract description 8
- 229960002154 guar gum Drugs 0.000 claims abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 8
- 239000000080 wetting agent Substances 0.000 claims abstract description 7
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 6
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 6
- 239000011734 sodium Substances 0.000 claims description 40
- 229910052708 sodium Inorganic materials 0.000 claims description 40
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 40
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims description 39
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 39
- 229960002350 guaiazulen Drugs 0.000 claims description 39
- 229940085605 saccharin sodium Drugs 0.000 claims description 16
- 230000002421 anti-septic effect Effects 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 10
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 7
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 7
- 239000013538 functional additive Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- -1 abrasivus Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 230000008719 thickening Effects 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 2
- 238000007670 refining Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 16
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000008961 swelling Effects 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 208000007565 gingivitis Diseases 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 235000003599 food sweetener Nutrition 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- 230000002335 preservative effect Effects 0.000 abstract 2
- 239000003765 sweetening agent Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical group OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 229920000591 gum Polymers 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000003266 anti-allergic effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000013521 mastic Substances 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 208000007117 Oral Ulcer Diseases 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003402 anti-promotion Effects 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention discloses a Chinese herbal medicine toothpaste containing radix notoginseng total saponins and lignum vitae sodium azulenesulfonate. The Chinese herbal medicine toothpaste comprises a functional annexing agent, a friction agent, a wetting agent, a binding agent, a surface active agent, a sweetening agent, an essence, a preservative and water, wherein the functional annexing agent comprises radix notoginseng total saponins and lignum vitae sodium azulenesulfonate; the friction agent comprises one or two out of calcium carbonate and silicon dioxide; the wetting agent comprises two out of sorbitol and polyethylene glycol 400 (or propylene glycol); the binding agent comprises one or two out of cellulose gum, carrageenan or guar gum; the surface active agent is sodium lauryl sulfate; the sweetening agent is saccharin sodium salt; the preservative is Germall II or sodium benzoate; the balance is the essence and the water. The functional components of the radix notoginseng total saponins and the lignum vitae sodium azulenesulfonate are safe and nontoxic, and do not damage the health. Through compounding, the toothpaste containing the radix notoginseng total saponins and the lignum vitae sodium azulenesulfonate is low in cost, good in effect, remarkable in effect on the aspect of resisting bacteria and diminishing the inflammation, clearing heat and subsiding the swelling and the like, and good in prevention and treatment effect for common redness and swelling and bleeding of the gum, gingivitis, dental plaque, dental ulcer and the like.
Description
Technical field
The present invention relates to a kind of Chinese herbal toothpaste, containing Radix Notoginseng total saponins, Kessazulen sodium sulfonate specifically, can have prevention and effect to alleviate the Chinese herbal toothpaste of the multiple oral problem such as red swelling of gingiva is hemorrhage, gingivitis, dental plaque, oral ulcer, and cost is lower, effect is remarkable.
Background technology
Radix Notoginseng sweet in the mouth, micro-hardship, warm in nature, nontoxic, be just acknowledged as since ancient times there is significant blood circulation promoting and blood stasis dispelling, styptic powder blood analgesic therapy effect, there is the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".Modern study shows, its total saponins constituents drug activity is the most remarkable, has the effect of the time that heart tonifying, vasoconstrictive, shortening clotting time and thrombin form, and invigorating blood circulation, aspect hemostasis, anti-inflammatory analgesic, application is wider.Along with modern Chinese medicine extractive technique is constantly progressive, Radix Notoginseng total saponins extraction process is day by day consummate, has improved widely active constituent content, purity improves constantly, reach 80～96%, for storing and transportation is provided convenience, be more conducive to acquisition and the application of Radix Notoginseng total saponins.
Kessazulen sodium sulfonate, chemical name: 1,4-dimethyl-7-isopropyl azulene-3-sodium sulfonate, it has stronger biological activity, there are anti-inflammation, anti-allergic effects and promotion function of tissue regeneration, safe because of it, in industries such as medicine, health product and cosmetics, be widely used, particularly its some pharmaceutical preparatioies effect aspect the treatment of antiallergic and oral disease and prevention is remarkable.
Notoginseng extract and the application of Sodium Azulenesulfonate in toothpaste at present still has some documents and patent report, but in general, have that Radix Notoginseng extracting solution effective ingredient used---total saponins purity is not high, consumption is large, poor effect, quality control level is low waits deficiency, so that storage, transportation and production application cost are too high.Formula as disclosed in patent CN200910304069.2, its Radix Notoginseng extracting solution consumption used is large, purity is low, will certainly affect its action effect, after composite with Sodium Azulenesulfonate, also need to add enzyme preparation to carry out composite synergism, although its object is to improve enzymatic activity, reach certain curative effect, increased undoubtedly production cost.
Summary of the invention
The object of the invention is to invent a kind of can reducing costs, material combination is precise and appropriate, utilize the synergism of Radix Notoginseng total saponins, two kinds of anti-inflammations of Kessazulen sodium sulfonate and analgesic agent, obtain a kind of antibiotic, antiinflammatory, analgesia more effectively and use the safer Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate.
Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate of the present invention, is characterized in that: comprise functional additive, abrasivus, wetting agent, binding agent, surfactant, sweeting agent, essence, antiseptic, water:
Described functional additive is Radix Notoginseng total saponins and Kessazulen sodium sulfonate, it accounts for mass percent in whole toothpaste component is Radix Notoginseng total saponins 0.001～0.5% and Kessazulen sodium sulfonate 0.001～0.2%, is preferably Radix Notoginseng total saponins 0.03～0.3% and Kessazulen sodium sulfonate 0.02～0.1%.Wherein said Radix Notoginseng total saponins is that this extract total saponin content is 80% ~ 100% through the high-purity solubility dried powder extract of refining purification gained, and its purity is much higher than ethanol extractum or alcoholic extract, is convenient to storage, transportation and production application;
Described abrasivus is calcium carbonate and/or silicon dioxide, and it accounts for mass percent and is in whole toothpaste component: calcium carbonate 20～50% and/or silicon dioxide 2～25%.If abrasivus is calcium carbonate and silica mixture, described silicon dioxide is only thickening type silicon dioxide, and its mass percent is preferably 2 ~ 10% or 5 ~ 15%; If abrasivus is only silicon dioxide, described silicon dioxide is comprised of friction-type silicon dioxide and thickening type silicon dioxide, and its mass percent is preferably 15 ~ 25%;
Described wetting agent is sorbitol and PEG400 or propylene glycol, and it accounts for mass percent and is preferably in whole toothpaste component: sorbitol 10～65% and PEG400 1～10% or propylene glycol 1～10%;
Described binding agent is cellulose gum, carrageenan or guar gum, and it accounts for mass percent and is in whole toothpaste component: cellulose gum 0.3～1.2%, carrageenan 0.1～0.3% or guar gum 0.3～0.6%.If abrasivus is calcium carbonate and silica mixture, cellulose gum mass percent is preferably 0.8 ~ 1.2%; If abrasivus is only silicon dioxide, cellulose gum percentage ratio is preferably 0.3 ~ 0.8%;
Described surfactant is sodium lauryl sulfate, and it accounts for mass percent in whole toothpaste component is 1～4%, is preferably 2～3%;
Described sweeting agent is saccharin sodium, and it accounts for mass percent in whole toothpaste component is 0.1 ~ 0.5%, is preferably 0.2～0.3%;
Described essence amount ranges 0.5～2.0%, preferably 1.0～1.5%;
Described antiseptic is germall B or sodium benzoate, and it accounts for mass percent in whole toothpaste component is 0.1 ~ 0.5%, preferably 0.2～0.4%;
Described hydromining deionized water, it accounts for mass percent in whole toothpaste component is 5～30%, preferably 10～25%.
Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate of the present invention, is characterized in that: the best in quality percentage ratio of described whole compositions has four kinds of combinations:
The first combination, Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, calcium carbonate 20～50%, silicon dioxide 2～10%, sorbitol 20～30%, PEG400 1～10%, cellulose gum 0.8～1.2%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.3～0.4%, water 20～30%.
The second combination, Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, calcium carbonate 20～50%, silicon dioxide 5～15%, sorbitol 10～20%, propylene glycol 5～10%, cellulose gum 0.8～1.2%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.3～0.4%, water 20～30%.
The 3rd combination, Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, silica 1 5～25%, sorbitol 55～65%, propylene glycol 1～10%, cellulose gum 0.3～0.8%, carrageenan 0.1～0.3%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.2～0.3%, water 10～20%.
The 4th kind of combination, Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, silica 1 5～25%, sorbitol 40～55%, propylene glycol 1～10%, cellulose gum 0.3～0.8%, guar gum 0.3～0.6%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.2～0.3%, water 20～30%.
The mastic manufacture method of the Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate of the present invention is as follows: with part water, dissolves in advance sweeting agent, functional additive (Radix Notoginseng total saponins and Kessazulen sodium sulfonate), antiseptic and obtains mixed aqueous solution, and stand-by; In abrasivus, add binding agent and surfactant, and mix homogeneously obtains mixed material, stand-by; The water of wetting agent and remaining part is joined in cream pot processed, the mixed aqueous solution that adds again sweeting agent, functional additive (Radix Notoginseng total saponins and Kessazulen sodium sulfonate) and antiseptic, stir, and then add the mixed material of abrasivus, binding agent and surfactant, stir, finally add essence, homogenizing agitation grinding, degassed.Prepared by mastic.
Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate of the present invention, because Radix Notoginseng total saponins is the main effective ingredient of Radix Notoginseng, there is strong anti-oxidation and invigorate blood circulation, the effect of hemostasis, analgesic, in aqueous solution, there is good dissolubility, at low concentration, do not have hemolytic, safety is good; Kessazulen sodium sulfonate, has stronger biological activity, has anti-inflammation, anti-allergic effects and promotion function of tissue regeneration.The present invention is by adding Radix Notoginseng total saponins and Kessazulen sodium sulfonate effect ingredient, when making the present invention there is cleaning teeth effect, also there is the effect of good anti-inflammation, hemostatic analgesia, energy balance oral environment, conditioning oral icrocirculation, reduces the generation of the oral diseases such as red swelling of gingiva is hemorrhage, gingivitis, dental plaque, oral ulcer.And cost is lower, use safer.
The specific embodiment
Below in conjunction with embodiment, the Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate of the present invention is described further.
Implement formula 1:
Radix Notoginseng total saponins 0.001%, Kessazulen sodium sulfonate 0.001%, calcium carbonate 48%, silicon dioxide 2%, sorbitol 20%, PEG400 3%, cellulose gum 1.2%, sodium lauryl sulfate 2.5%, saccharin sodium 0.25%, essence 1.3%, germall B 0.3%, surplus is deionized water.
Implement formula 2:
Radix Notoginseng total saponins 0.03%, Kessazulen sodium sulfonate 0.02%, calcium carbonate 35%, silicon dioxide 7%, sorbitol 18%, propylene glycol 8%, cellulose gum 0.8%, sodium lauryl sulfate 2.5%, saccharin sodium 0.25%, essence 1.1%, sodium benzoate 0.3%, surplus is deionized water.
Implement formula 3:
Radix Notoginseng total saponins 0.25%, Kessazulen sodium sulfonate 0.1%, silica 1 5%, sorbitol 60%, propylene glycol 3%, cellulose gum 0.4%, carrageenan 0.28%, sodium lauryl sulfate 2.3%, saccharin sodium 0.25%, essence 1.3%, germall B 0.2%, surplus is deionized water.
Implement formula 4:
Radix Notoginseng total saponins 0.3%, Kessazulen sodium sulfonate 0.1%, silicon dioxide 20%, sorbitol 60%, propylene glycol 3%, cellulose gum 0.4%, carrageenan 0.28%, sodium lauryl sulfate 2.3%, saccharin sodium 0.25%, essence 1.3%, germall B 0.2%, surplus is deionized water.
Implement formula 5:
Radix Notoginseng total saponins 0.5%, Kessazulen sodium sulfonate 0.2%, silicon dioxide 20%, sorbitol 45%, propylene glycol 5%, cellulose gum 0.8%, guar gum 0.4%, sodium lauryl sulfate 2.5%, saccharin sodium 0.25%, essence 1.3%, sodium benzoate 0.2%, surplus is deionized water.
Manufacture method is:
(1) by above-mentioned formula 1～5 requirement, take raw material;
(2) part deionized water is poured in premix pot;
(3) by Radix Notoginseng total saponins, Kessazulen sodium sulfonate, saccharin sodium, germall B(or sodium benzoate) pour in premix pot, open the stirring of premix pot until material dissolution obtains mixed aqueous solution;
(4) by cellulose gum or/and carrageenan (or guar gum), sodium lauryl sulfate, calcium carbonate and/or silicon dioxide add in powder premix pot, open to stir until mix homogeneously obtains mixed material;
(5) sorbitol and PEG400 (or propylene glycol) and remainder deionized water are added in cream pot processed;
(6) mixed aqueous solution in (3) is added in cream pot processed, open stirring scratch board material stirring in pot is even;
(7) mixed material in (4) is added in cream pot processed, in adition process, continue to stir;
(8) essence is added in cream pot processed;
(9) under vacuum condition, open homogenizing and scraper plate stirring, homogenizing grinding 15～30 minutes, degassed;
(10) stop stirring, proportion is surveyed in sampling, the qualified rear sample presentation chemical examination of proportion;
(11) sample presentation result of laboratory test all reaches standard-required, prepared by mastic.
Claims (7)
1. containing a Chinese herbal toothpaste for Radix Notoginseng total saponins and Kessazulen sodium sulfonate, it is characterized by: comprise functional additive, abrasivus, wetting agent, binding agent, surfactant, sweeting agent, essence, antiseptic, water:
Described functional additive comprises the component of following mass percent: Radix Notoginseng total saponins 0.001～0.5% and Kessazulen sodium sulfonate 0.001～0.2% two are kind composite;
Described abrasivus comprises the component of following mass percent: calcium carbonate 20～50% and/or silicon dioxide 2～25%;
Described wetting agent comprises the component of following mass percent: sorbitol 10～65% and PEG400 1～10% or sorbitol 10～65% and propylene glycol 1～10%;
Described binding agent comprises the component of following mass percent: wherein one or both mixing of cellulose gum 0.2～2.0%, carrageenan 0.1～1.0% or guar gum 0.1～1.0%;
Described surfactant comprises the component of following mass percent: sodium lauryl sulfate 1.0～4.0%;
Described sweeting agent comprises the component of following mass percent: saccharin sodium 0.1～0.5%;
Described antiseptic comprises the component of following mass percent: germall B or sodium benzoate 0.1～0.5%;
Surplus is essence 0.5～2.0%, water 5～30%.
2. according to claim 1 containing the Chinese herbal toothpaste of Radix Notoginseng total saponins and Kessazulen sodium sulfonate, it is characterized in that:
The best in quality percentage ratio of described whole compositions is: Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, calcium carbonate 20～50%, silicon dioxide 2～10%, sorbitol 20～30%, PEG400 1～10%, cellulose gum 0.8～1.2%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.3～0.4%, water 20～30%.
3. according to claim 1 containing the Chinese herbal toothpaste of Radix Notoginseng total saponins and Kessazulen sodium sulfonate, it is characterized in that:
The best in quality percentage ratio of described whole compositions is: Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, calcium carbonate 20～50%, silicon dioxide 5～15%, sorbitol 10～20%, propylene glycol 5～10%, cellulose gum 0.8～1.2%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.3～0.4%, water 20～30%.
4. according to claim 1 containing the Chinese herbal toothpaste of Radix Notoginseng total saponins and Kessazulen sodium sulfonate, it is characterized in that:
The best in quality percentage ratio of described whole compositions is: Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, silica 1 5～25%, sorbitol 55～65%, propylene glycol 1～10%, cellulose gum 0.3～0.8%, carrageenan 0.1～0.3%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.2～0.3%, water 10～20%.
5. according to claim 1 containing the Chinese herbal toothpaste of Radix Notoginseng total saponins and Kessazulen sodium sulfonate, it is characterized in that:
The best in quality percentage ratio of described whole compositions is: Radix Notoginseng total saponins 0.03～0.3%, Kessazulen sodium sulfonate 0.02～0.1%, silica 1 5～25%, sorbitol 40～55%, propylene glycol 1～10%, cellulose gum 0.3～0.8%, guar gum 0.3～0.6%, sodium lauryl sulfate 2～3%, saccharin sodium 0.2～0.3%, essence 1.0～1.5%, antiseptic 0.2～0.3%, water 20～30%.
6. according to the Chinese herbal toothpaste containing Radix Notoginseng total saponins and Kessazulen sodium sulfonate described in claim 1 to 5, it is characterized in that: described Radix Notoginseng total saponins is that this extract total saponin content is 80% ~ 100% through the high-purity solubility dried powder extract of refining purification gained.
7. according to containing the Chinese herbal toothpaste of Radix Notoginseng total saponins and Kessazulen sodium sulfonate described in claim 1 to 5, it is characterized in that: if abrasivus is calcium carbonate and silica mixture, described silicon dioxide is only thickening type silicon dioxide; If abrasivus is only silicon dioxide, described silicon dioxide is comprised of friction-type silicon dioxide and thickening type silicon dioxide.
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| WO2015172345A1 (en) * | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Oral care compositions containing polyethylene glycol for physical stability |
| CN105288721A (en) * | 2015-10-16 | 2016-02-03 | 天津市顶硕科贸有限公司 | Liquid band-aid and preparation technology thereof |
| CN107970150A (en) * | 2017-11-16 | 2018-05-01 | 盐城金昉首乌科技发展有限公司 | A kind of cynanchum auriculatum Royle toothpaste and preparation method thereof |
| CN108670881A (en) * | 2018-08-16 | 2018-10-19 | 苏州清馨健康科技有限公司 | Whitening maintenance toothpaste |
| CN112438901A (en) * | 2019-09-04 | 2021-03-05 | 诗乐氏实业（深圳）有限公司 | Foam toothpaste and preparation method thereof |
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| WO2015172346A1 (en) * | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Oral care compositions containing polyethylene glycol for physical stability |
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Application publication date: 20140205 |