CN103462845B - Composite whitening spot-dispelling frost and manufacture method - Google Patents

Abstract

The invention specifically discloses a compound whitening and freckle-removing cream and a preparation method thereof. The weight percentage of the raw materials of the freckle removing liquid is: 1-25% of active part extract of traditional Chinese medicine, 0.1-10% of isooctyl ferulate, 0.1-5% of vitamin C ethyl ether, 0.05-3% of nicotinamide, 10-10% of oil 40%, emulsifier 1-6%, humectant 1-15%, preservative 0.1-1.5%, essence 0.1-0.5%, and the balance is deionized water. The compound whitening and freckle-removing cream of the present invention can effectively inhibit the activity of tyrosinase, efficiently remove oxygen free radicals, prevent the production of melanin, decompose and dilute the formed melanin, and at the same time regulate the endocrine system of the human body, repair the chemical components caused by hormones, etc. Damage caused to the skin, so as to achieve a comprehensive and rapid effect of treating both symptoms and root causes.

Description

Compound whitening and freckle removing cream and its preparation method

technical field

The invention relates to a compound whitening and freckle-removing cream, in particular to a compound whitening and freckle-removing cream and a preparation method thereof.

Background technique

Everyone has a desire for beauty, but many women are troubled by freckles and melasma on their faces. Freckles and chloasma are a common skin phenomenon in which a large amount of melanin is deposited unevenly in the human body and is difficult to cure, which seriously affects the mental health of patients.

Traditional Chinese medicine sums up the cause of spots on the face in one sentence: "There are spots on the face, and there are bruises in the body. If there are spots, there will be bruises. The blood stasis cannot be cured." Qi stagnation and blood stasis in unused parts of the body will appear on the face. The corresponding parts appear, and spots are formed. When the human body's endocrine is disordered, the Qi and blood in the human body are not running smoothly, and the meridians are blocked, resulting in stagnation of blood stagnation, stagnation of Qi, hard work cannot reach the skin, nourish the skin, and the melanin in the skin cannot follow the human body. Normal metabolism is excreted, so for a long time, stains are formed. Similarly, sun exposure and long-term use of cosmetics containing lead, mercury, and hormone-like chemicals will destroy the thin tissue structure of the epidermis and accelerate the deposition of pigmentation. Qi stagnation and blood stasis and lesions in different parts of the body will appear as plaques on the opposite part of the face. Therefore, the main method to solve the problem of color spots is: on the one hand, pay attention to diet, avoid eating too much junk food, and eat more light food can relieve the formation of color spots; second, develop good living rules and habits, Do not smoke or drink alcohol; the third is to use safe whitening and freckle-removing products to remove melanin in the skin and pigmentation of the epidermis.

At present, there are many whitening and freckle-removing products on the market, and the whitening and freckle-removing ingredients contained in them mainly include: arbutin, hydroquinone, vitamin C, kojic acid, azelaic acid, cell growth factors, etc. These products have the following problems: (1) they can only be effective for certain pigmentation spots, for example, arbutin can only be effective for chloasma, but not for freckles. (2) There is irritation and damage to the skin. For example, cosmetics containing hydroquinone are more likely to cause systemic poisoning. For example, when kojic acid is added in a large amount, it is easy to cause contact dermatitis. (3) Unstable and easy to change color, such as vitamin C is not conducive to skin absorption, and it is easy to oxidize and change color when exposed to heat and light, thus losing the whitening effect; the active shelf life of cell growth factors is short, and it is not easy to store for a long time.

Contents of the invention

In order to solve the problems existing in the existing whitening and freckle-removing products, the purpose of the present invention is to provide a compound whitening and freckle-removing cream with comprehensive curative effect and safety and its preparation method.

For realizing the above-mentioned purpose of the invention, the technical scheme adopted in the present invention is as follows:

Composite whitening and spot-removing cream, its raw material percentage by weight is:

Active part extract of traditional Chinese medicine 1-25%, isooctyl ferulate 0.1-10%, vitamin C ethyl ether 0.1-5%, nicotinamide 0.05-3%, oil 10-40%, emulsifier 1-6% , Humectant 1-15%, preservative 0.1-1.5%, essence 0.1-0.5%, deionized water 10-80%. Wherein, the raw material percentage by weight of the extract of the active part of the traditional Chinese medicine is: 5-25% of grape seed, 5-25% of Rhizoma Chuanxiong, 5-25% of peony flower, 5-30% of Morus alba bark, 5-35% of hibiscus flower , Glycyrrhizae glabra 5-25%. The oil is at least 4 or more of the following oils: 6-10% mineral oil, 3-10% caprylic/capric triglyceride, 3-10% C12-15 alcohol benzoate, cyclopolymer Dimethicone 4-10%, Tocopheryl Acetate 0.5-1%, Dimethicone and Dimethiconol 0.5-5%, Hydrogenated Polyisobutylene 2-5%, Isopropyl palmitate 1-8%. The emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane 2-3%, lecithin 0.5-1%, methyl glucose sesquistearate 0.5-1.5%, At least two or more of glyceryl stearate 0.1-2%, PEG-10 polydimethylsiloxane 1-3%. The moisturizing agent is 3-8% of 1,3-butanediol, 2-8% of 1,2-propanediol, 2-8% of glycerin, 0.01-0.3% of sodium hyaluronate, 0.5-2.0% of sodium PCA, At least one or more of allantoin 0.1-0.5%. The preservative is composed of 0.05-0.4% methylparaben, 0.05-0.2% propylparaben and 0.1-0.5% phenoxyethanol.

Preferably, the percentage by weight of the raw materials of the compound whitening and freckle-removing cream is:

Chinese medicine active part extract 15%, isooctyl ferulate 5%, vitamin C ethyl ether 2%, nicotinamide 1.8%, oil 24%, emulsifier 3.5%, humectant 6.3%, preservative 0.6%, essence 0.2%, the balance is deionized water. Wherein, the raw material percentage by weight of the active part extract of the traditional Chinese medicine is: 20% of grape seed, 20% of Rhizoma Chuanxiong, 10% of Peony, 20% of Cortex Mori, 12% of Hibiscus, and 18% of Glycyrrhiza glabra. The grease described is: mineral oil 6%, caprylic/capric triglyceride 4%, C12-15 alcohol benzoate 6%, cyclomethicone 6%, polydimethylsiloxane and dimethiconol 2%. Described emulsifier is lecithin 0.6%, methyl glucose sesquistearate 1.2%, PEG-10 dimethicone 1.7%. The moisturizing agent is 6% of 1,3-butanediol, 0.1% of sodium hyaluronate, and 0.2% of allantoin. The preservatives are 0.2% methylparaben, 0.05% propylparaben, and 0.5% phenoxyethanol.

The preparation method of compound whitening and freckle-removing cream comprises the following steps:

(1) The extraction and purification method of the active part extract of traditional Chinese medicine is as follows:

Soak grape seeds, chuanxiong, peony, Morus alba, hibiscus, and licorice glabra active part extracts in 10-85% ethanol at a ratio of 1:5 to 1:15, Soaking time is 24-96 hours;

Then filter, recover the ethanol from the filtrate under reduced pressure at 50°C-80°C until there is no alcohol smell, add 2-5 times the amount of water to dilute, and then wash it with a macroporous resin column with a resin model of D101 or AB-8 until it is colorless , and then eluted with 20%-80% ethanol until the eluent is colorless, and collect the ethanol eluate, and then recover the ethanol under reduced pressure at 50°C-80°C until the ratio of medicinal liquid to medicinal material is 1:2 to 1:10 , to obtain the active part extract of traditional Chinese medicine;

(2) Add the extract of the active part of the traditional Chinese medicine, humectant, preservative, and deionized water into the water phase pot, heat up to 80-85°C, stir and dissolve, and form the water phase;

(3) Add oily materials such as isooctyl ferulate, vitamin C ethyl ether, nicotinamide, grease, emulsifier and other oily materials into the oil phase pot, stir and heat to 80-85°C, and pump them into the emulsification pot after the dispersion is complete to form oil Mutually;

(4) Slowly pump the material in the water phase pot into the emulsification pot through the filter screen for emulsification, stop homogenization after emulsification for 15-40 minutes, turn on the circulating water to cool down, keep stirring and vacuumize to defoam;

(5) Cool down to 45°C, add essence, stir evenly, continue to cool down to 38°C, and discharge to obtain the finished product.

Preferably, in the preparation method of the compound whitening and freckle-removing cream: before the step (1), the step of crushing the raw material of the active part extract of the traditional Chinese medicine into coarse powder is also included.

Preferably, in the preparation method of the compound whitening and freckle-removing cream: the ethanol concentration used to soak the raw material of the active part extract of the traditional Chinese medicine in the step (1) is 50%, and the ratio of the raw material of the active part extract of the traditional Chinese medicine to ethanol is 1:10, the soaking time is 48 hours.

Preferably, in the preparation method of the compound whitening and freckle-removing cream: the ethanol concentration used for elution in the step (1) is 70%.

The compound whitening and freckle-removing cream prepared by the invention is a combination of various traditional Chinese medicine ingredients, whitening and freckle-removing active components and base ingredients commonly used in cosmetics. Among them, grape seed extract is rich in vitamin E, has a very strong antioxidant function, and has anti-allergic, anti-radiation, skin protection, beauty and other effects. Chuanxiong extract has a very strong effect of promoting blood circulation and removing blood stasis, can promote blood circulation, and has a very strong effect of inhibiting tyrosinase activity. Glycyrrhiza glabra extract contains glabridin and other components, which have a very strong effect of inhibiting tyrosinase activity and melanocytes, and can effectively prevent the formation and excessive deposition of melanin, and can also effectively decompose and restore it in the skin the formation of melanin. Peony, Morus alba, and Hibiscus have strong activity of inhibiting tyrosinase, which can effectively inhibit the formation of melanin and dilute the already formed melanin. Isooctyl ferulate is a high-efficiency whitening agent that combines anti-oxidation, tyrosinase inhibition and ultraviolet absorption. Its anti-oxidation ability is 4 times that of vitamin E; it can effectively isolate the 280-360nm band Ultraviolet radiation has a very good sunscreen effect; it can strongly inhibit the activities of tyrosinase and DHICA enzymes, and has a strong whitening effect. Vitamin C ethyl ether has the following effects and properties: powerfully inhibits tyrosinase activity, prevents melanin synthesis, and effectively whitens and removes spots; promotes collagen synthesis, improves dull skin, and gives skin elasticity; strong anti-oxidation, effectively clears skin free radicals in the body; anti-inflammation caused by sunlight, has strong antibacterial and anti-inflammatory effects; has a lipophilic and hydrophilic structure, is easy to be absorbed by the skin, and can directly reach the dermis; good stability, light resistance, heat resistance, acid resistance, alkali resistance, Resistant to salt and air oxidation. Niacinamide is a recognized skin anti-aging ingredient in the field of cosmetic dermatology. Its most important effect in skin anti-aging is to prevent and alleviate the dull complexion and yellow gas produced in the early aging process of the skin, and it can promote the rapid discharge of melanin that has already been produced. in vitro. Commonly used matrix components in cosmetics, such as oil, are skin lubricants and penetration enhancers for active ingredients; moisturizers can efficiently maintain skin moisture, and can also promote active ingredients to be absorbed by the skin.

The compound whitening and freckle-removing cream of the present invention applies the theory of combining traditional Chinese and Western medicine, and adds a variety of active ingredients of traditional Chinese medicine to the active ingredients of whitening and freckle-removing. The activity of enzymes can efficiently remove oxygen free radicals, prevent the production of melanin, decompose and dilute the formed melanin, and at the same time, it can regulate the endocrine system of the human body and repair the damage caused by hormones and other chemical components to the skin, so as to achieve comprehensive and rapid treatment of both symptoms and root causes. Effect. The compound whitening and freckle-removing cream of the invention does not contain poisonous and harmful substances to human body, and is a safe and effective product.

Detailed ways

The present invention will be described in detail below in conjunction with specific implementation methods. The schematic implementation and description of the present invention are used to explain the present invention, but not as a limitation to the present invention.

Example 1: Compound whitening and freckle removing cream

This example discloses the formula of compound whitening and freckle-removing cream and its preparation method, and its formula is shown in Table 1.

Table 1

Wherein, the raw material percentage by weight of the active part extract of the traditional Chinese medicine is: 20% of grape seed, 20% of Rhizoma Chuanxiong, 10% of Peony, 20% of Cortex Mori, 12% of Hibiscus, and 18% of Glycyrrhiza glabra.

The preparation method of the compound whitening and freckle-removing cream of the present embodiment is realized in this way:

(1) The extraction and purification method of the active part extract of traditional Chinese medicine is as follows:

Mix and pulverize the raw materials of grape seed, Chuanxiong, Peony, Morus alba, Hibiscus, and Glycyrrhiza glabra into coarse powder, soak in 40% ethanol according to the ratio of 1:8 drug to solvent, soaking time for 24 hours;

Then filter, recover the ethanol from the filtrate under reduced pressure at 60°C until there is no alcohol smell, add 2 times the amount of water to dilute, and then wash it with a macroporous resin column with a resin model of D101 until it is colorless, and then elute it with 60% ethanol to The eluate is colorless, and the ethanol eluate is collected, and then the ethanol is recovered under reduced pressure at 60°C until the ratio of the liquid to the medicinal material is 1:5, and the extract of the active part of the traditional Chinese medicine is obtained;

(2) Add the active part extract of the traditional Chinese medicine, deionized water and other water phase ingredients into the water phase pot, heat up to 85°C, stir and dissolve, and form the water phase;

(3) Add mineral oil, isooctyl ferulate, vitamin C ethyl ether, nicotinamide, cetyl PEG/PPG-10/1 polydimethylsiloxane, lecithin and other oil phase ingredients into the oil phase pot, stir and heat to 85°C, pump it into the emulsification pot after the dispersion is complete, and it becomes the oil phase;

(4) Slowly pump the material in the water phase pot into the emulsification pot through the filter screen for emulsification, stop homogenization after 25 minutes of emulsification, turn on the circulating water to cool down, keep stirring and vacuumize to defoam;

(5) Cool down to 45°C, add essence, stir evenly, continue to cool down to 38°C, and discharge to obtain the finished product.

Example 2: Compound whitening and freckle removing cream

This example discloses the formula of compound whitening and freckle-removing cream and its preparation method, and its formula is shown in Table 2.

Table 2

Wherein, the raw material weight percent of the active part extract of the traditional Chinese medicine is: grape seed 18%, Chuanxiong 18%, Peony 10%, Morus alba 20%, Hibiscus 15%, Glycyrrhiza glabra 19%.

The manufacturing method of the invention described in the embodiment of the present invention is basically the same as that of Example 1, the difference is: the ethanol concentration used to soak the medicinal powder in the step (1) is 60%, and the active part extract raw material of the described Chinese medicine is mixed with ethanol The ratio is 1:10, the soaking time is 20 hours, and the concentration of ethanol used for elution is 75%.

Example 3: Compound whitening and freckle removing cream

This example discloses the formula of compound whitening and freckle-removing cream and its preparation method, and its formula is shown in Table 3.

table 3

Wherein, the raw material percentage by weight of the active part extract of the traditional Chinese medicine is: grape seed 15%, Chuanxiong 23%, Peony 15%, Morus alba 20%, Hibiscus 12%, Glycyrrhiza glabra 15%.

The manufacturing method of the invention described in the embodiment of the present invention is basically the same as that of Example 1, except that the ethanol concentration of soaking the medicinal powder is 50%, and the soaking time is 30 hours. The type of macroporous resin used for purification was AB-8, and the concentration of ethanol used to elute from the macroporous resin column was 70%.

Example 4: Evaluation of Whitening and Spot Removing Effects

Evaluation objects: middle-aged women aged 30-55. Select 56 cases of females with different degrees of chloasma, freckles, butterfly spots, age spots and other pigmented spots on the face.

Evaluation method: After washing the face every morning, take 3-5g of the compound whitening and freckle-removing cream prepared in Example 1 and apply it to the spots on the face, and apply it again after washing the face before going to bed at night. 40 days is a course of treatment.

Evaluation criteria: ①healed: the pigmentation basically disappeared; ②marked effect: the pigmentation faded by more than 50%; ③effective: the pigmentation faded by more than 10%, or the pigmentation became lighter; ④ineffective: no change before and after use.

Evaluation results: 18 cases were cured, accounting for 32.1%; 29 cases were markedly effective, accounting for 51.8%; 7 cases were effective, accounting for 12.5%; 2 cases were ineffective, accounting for 3.6%. The total effective rate reached 96.4%.

Claims (2)

1. Compound whitening and freckle-removing cream, characterized in that the weight percentage of raw materials is: 1-25% of active part extract of traditional Chinese medicine, 0.1-10% of isooctyl ferulate, 0.1-5% of vitamin C ethyl ether, 0.05-5% of nicotinamide 3%, oil 10-40%, emulsifier 1-6%, moisturizer 1-15%, preservative 0.1-1.5%, essence 0.1-0.5%, deionized water 10-80%; The raw material weight percent of active part extract is: grape seed 5-25%, Chuanxiong 5-25%, peony flower 5-25%, Morus alba 5-30%, hibiscus flower 5-35%, licorice glabra 5- 25%, the oils are at least 4 or more of the following oils: 6-10% mineral oil, 3-10% caprylic/capric triglycerides, 3-10% C12-15 alcohol benzoate , Cyclomethicone 4-10%, Tocopheryl Acetate 0.5-1%, Dimethicone and Dimethiconol 0.5-5%, Hydrogenated Polyisobutylene 2- 5%, isopropyl palmitate 1-8%, the emulsifier is cetyl PEG/PPG-10/1 polydimethylsiloxane 2-3%, lecithin 0.5-1%, methyl At least two or more of 0.5-1.5% glucosesquistearate, 0.1-2% glycerol stearate, and 1-3% PEG-10 polydimethylsiloxane, the moisturizer 1,3-butanediol 3-8%, 1,2-propanediol 2-8%, glycerin 2-8%, sodium hyaluronate 0.01-0.3%, PCA sodium 0.5-2.0%, allantoin 0.1- At least one or more of 0.5%, the preservative is composed of three substances: methylparaben 0.05-0.4%, propylparaben 0.05-0.2%, and phenoxyethanol 0.1-0.5%. 2. the preparation method of compound whitening and spot-removing cream according to claim 1 is characterized in that comprising the following steps: (1) The extraction and purification method of the active part extract of traditional Chinese medicine is as follows: Soak grape seeds, chuanxiong, peony, Morus alba, hibiscus, and licorice glabra active part extracts in 10-85% ethanol at a ratio of 1:5 to 1:15, The soaking time is 24-96 hours; then filter, the filtrate is decompressed at 50°C-80°C to recover ethanol until there is no alcohol smell, add 2-5 times the amount of water to dilute, and then add resin model D101 or AB-8 large After the porous resin column is washed with water until it is colorless, it is then eluted with 20%-80% ethanol until the eluent is colorless, and the ethanol eluate is collected, and then the ethanol is recovered under reduced pressure at 50°C-80°C until the ratio of the liquid to the medicinal material is reached. The ratio of 1:2 to 1:10 is used to obtain the active part extract of traditional Chinese medicine; (2) Add the extract of the active part of the traditional Chinese medicine, humectant, preservative, and deionized water into the water phase pot, heat up to 80-85°C, stir and dissolve, and form the water phase; (3) Add isooctyl ferulate, vitamin C ethyl ether, nicotinamide, oil, and emulsifier into the oil phase pot, stir and heat to 80-85°C, and pump it into the emulsification pot after the dispersion is complete to form the oil phase; (4) Slowly pump the material in the water phase pot into the emulsification pot through the filter screen for emulsification, stop homogenization after emulsification for 15-40 minutes, turn on the circulating water to cool down, keep stirring and vacuumize to defoam; (5) Cool down to 45°C, add essence, stir evenly, continue to cool down to 38°C, and discharge to obtain the finished product.