CN116549353B - Composition with whitening effect containing peony extract and preparation method thereof - Google Patents
Composition with whitening effect containing peony extract and preparation method thereof Download PDFInfo
- Publication number
- CN116549353B CN116549353B CN202310602676.7A CN202310602676A CN116549353B CN 116549353 B CN116549353 B CN 116549353B CN 202310602676 A CN202310602676 A CN 202310602676A CN 116549353 B CN116549353 B CN 116549353B
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- peony
- composition
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000284 extract Substances 0.000 title claims abstract description 83
- 235000006484 Paeonia officinalis Nutrition 0.000 title claims abstract description 80
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 230000002087 whitening effect Effects 0.000 title claims abstract description 26
- 241000736199 Paeonia Species 0.000 title claims description 77
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000000605 extraction Methods 0.000 title 1
- 238000004108 freeze drying Methods 0.000 claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000011550 stock solution Substances 0.000 claims abstract description 21
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 21
- 229930003935 flavonoid Natural products 0.000 claims abstract description 20
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 20
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims abstract description 17
- 241000208688 Eucommia Species 0.000 claims abstract description 17
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 claims abstract description 16
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 16
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims abstract description 16
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims abstract description 16
- 229960000367 inositol Drugs 0.000 claims abstract description 16
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 15
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 15
- 230000008569 process Effects 0.000 claims abstract description 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 14
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 14
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 14
- XYTHHAXRVHHXKO-JIUYZRCGSA-N 18-[(2r,3s,4r,5r)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxyoctadecanoic acid;ethanol Chemical compound CCO.COC1O[C@H](CO)[C@@H](OCCCCCCCCCCCCCCCCCC(O)=O)[C@H](O)[C@H]1O XYTHHAXRVHHXKO-JIUYZRCGSA-N 0.000 claims abstract description 13
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 12
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 12
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 claims abstract description 12
- 229940010454 licorice Drugs 0.000 claims abstract description 12
- 235000020725 licorice root extract Nutrition 0.000 claims abstract description 12
- 229940051810 licorice root extract Drugs 0.000 claims abstract description 12
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 11
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 11
- 229940119217 chamomile extract Drugs 0.000 claims abstract description 11
- 235000020221 chamomile extract Nutrition 0.000 claims abstract description 11
- 240000008632 Cota tinctoria Species 0.000 claims abstract description 9
- 150000002215 flavonoids Chemical class 0.000 claims abstract description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 4
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 55
- 238000007710 freezing Methods 0.000 claims description 37
- 230000008014 freezing Effects 0.000 claims description 37
- 238000003756 stirring Methods 0.000 claims description 30
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 15
- -1 flavonoid compound Chemical class 0.000 claims description 15
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 239000000419 plant extract Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 10
- 238000005192 partition Methods 0.000 claims description 10
- 238000000859 sublimation Methods 0.000 claims description 10
- 230000008022 sublimation Effects 0.000 claims description 10
- 244000131316 Panax pseudoginseng Species 0.000 claims description 9
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 9
- 229940107131 ginseng root Drugs 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 6
- 229960005150 glycerol Drugs 0.000 claims description 5
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 4
- 230000001815 facial effect Effects 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000011477 liquorice Nutrition 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 10
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 244000170916 Paeonia officinalis Species 0.000 abstract 3
- 239000002131 composite material Substances 0.000 abstract 1
- 229940042585 tocopherol acetate Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 28
- 230000000052 comparative effect Effects 0.000 description 14
- 239000002994 raw material Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 description 4
- 229940093767 glabridin Drugs 0.000 description 4
- PMPYOYXFIHXBJI-ZDUSSCGKSA-N glabridin Natural products C1([C@H]2CC=3C=CC4=C(C=3OC2)CCC(O4)(C)C)=CC=C(O)C=C1O PMPYOYXFIHXBJI-ZDUSSCGKSA-N 0.000 description 4
- LBQIJVLKGVZRIW-UHFFFAOYSA-N glabridine Natural products C1OC2=C3C=CC(C)(C)OC3=CC=C2CC1C1=CC=C(O)C=C1O LBQIJVLKGVZRIW-UHFFFAOYSA-N 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 4
- 230000000975 bioactive effect Effects 0.000 description 3
- 230000019522 cellular metabolic process Effects 0.000 description 3
- 235000005152 nicotinamide Nutrition 0.000 description 3
- 239000011570 nicotinamide Substances 0.000 description 3
- 229960003966 nicotinamide Drugs 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000202807 Glycyrrhiza Species 0.000 description 2
- 239000000899 Gutta-Percha Substances 0.000 description 2
- 240000005001 Paeonia suffruticosa Species 0.000 description 2
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 2
- 240000000342 Palaquium gutta Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 229920000588 gutta-percha Polymers 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- 229940120155 3-o-ethyl ascorbate Drugs 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- NGGYSPUAKQMTNP-UHFFFAOYSA-N Glabrene Chemical compound C1=C(O)C=C2OCC(C3=C4OC(C=CC4=C(O)C=C3)(C)C)=CC2=C1 NGGYSPUAKQMTNP-UHFFFAOYSA-N 0.000 description 1
- KKLOCFOZPFGVBB-UHFFFAOYSA-N Glabrene Natural products C1=C(O)C=C2OCC(C3=CC=C4OC(C=CC4=C3O)(C)C)=CC2=C1 KKLOCFOZPFGVBB-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012792 lyophilization process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000010117 shenhua Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical group 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
本发明属于护肤品制备技术领域，具体涉及一种含有牡丹提取物的具有美白功效的组合物及其制备方法。本发明组合物中各组分的重量份数为：牡丹鲜花瓣压榨原液0.5‑5份、牡丹籽油0.1‑1份，金黄洋甘菊提取物0.01‑1份，忍冬花提取物0.01‑1份，三七根提取物0.01‑1份，杜仲树皮提取物0.01‑1份，光果甘草根提取物和甘草类黄酮复配物0.01‑0.1份，3‑O‑乙基抗坏血酸0.1‑1份，烟酰胺0.5‑5份，PEG‑20甲基葡糖倍半硬脂酸酯0.1‑1份，生育酚乙酸酯0.1‑1份，低分子玻尿酸0.05‑0.5份，肌醇0.5‑3份，甘油2‑8份。本发明采用独特的冻干工艺处理获得组合物，各组分均能够产生协同效应，保持紫外线照射后的细胞活性，并抑制黑色素产生，从而达到美白肌肤的功效。The present invention belongs to the technical field of skin care product preparation, and specifically relates to a composition with whitening effect containing peony extract and a preparation method thereof. The weight proportions of each component in the composition of the present invention are: 0.5-5 parts of peony fresh petal squeezed stock solution, 0.1-1 parts of peony seed oil, 0.01-1 parts of golden chamomile extract, 0.01-1 parts of honeysuckle extract, 0.01-1 parts of notoginseng root extract, 0.01-1 parts of eucommia bark extract, 0.01-0.1 parts of licorice root extract and licorice flavonoids composite, 0.1-1 parts of 3-O-ethyl ascorbic acid, 0.5-5 parts of nicotinamide, 0.1-1 parts of PEG-20 methyl glucose sesquistearate, 0.1-1 parts of tocopherol acetate, 0.05-0.5 parts of low molecular weight hyaluronic acid, 0.5-3 parts of inositol, and 2-8 parts of glycerol. The present invention adopts a unique freeze-drying process to obtain the composition, and each component can produce a synergistic effect, maintain the cell activity after ultraviolet irradiation, and inhibit the production of melanin, thereby achieving the effect of whitening the skin.
Description
Technical Field
The invention belongs to the technical field of skin care product preparation, and particularly relates to a composition containing peony extract and having a whitening effect and a preparation method thereof.
Background
Melanin is a special amino acid derivative existing in basal layers of skin of each person, the melanin is changed by long-term ultraviolet irradiation to generate a substance for protecting the skin, and then the melanin moves layer by layer through cell metabolism to reach skin epidermis layers, so that skin problems of color spots, uneven skin color and the like seen by people are formed, and secret prescription for seeking skin whitening is always a target required by people.
The peony flower contains rich amino acids, trace elements, flavonoid and other bioactive components, and the peony seed oil extracted from peony seeds is rich in gallic acid, oleanolic acid and other unsaturated fatty acids, squalene, sterol, vitamin E and other rare natural active components, so that the peony flower has extremely high medicinal, edible and skin care values.
At present, cosmetics and skin care products containing peony extracts in the market are endless, but have the problems that the content of main functional components in the skin care products is small, so that the products are added with a large amount of artificially synthesized thickening agents, thickening agents and the like to improve the viscosity and consistency of the products and reduce the safety of the products in order to regulate the dosage forms of the products.
In addition, most of the products in the market at present are produced in a high-temperature and high-pressure homogenization mode, and the high temperature is fatal to the damage of natural plants, so that the active ingredients in the extracts added in the skin care products are easily deactivated, and the efficacy of the products is greatly reduced.
Disclosure of Invention
In order to solve the technical problems, the invention provides a composition containing peony extract and having a whitening effect and a preparation method thereof.
The composition containing the peony extract and having the whitening effect provided by the invention comprises the peony extract and the multiple plant extract composition.
The peony extract is peony fresh petal squeezing stock solution (PAEONIA SUFFRUTICOSA FLOWER WATER) and peony seed oil (PAEONIA SUFFRUTICOSA SEED OIL).
The peony fresh petal stock solution is prepared from raw ecological high-quality peony fresh flowers by adopting a physical cold pressing process, specifically a peony fresh petal cell solution, no exogenous water is added, natural active substance components in the peony fresh petal stock solution can be reserved to the maximum extent, and compared with rose hydrosol, the DPPH free radical and hydroxyl free radical removing capability of the peony fresh petal stock solution is 10 times of that of the peony fresh petal stock solution.
The peony seed oil, in particular to the easily absorbable small-molecule oil which is specially used as a cosmetic raw material and has no solvent residue and is obtained by a supercritical carbon dioxide extraction technology, contains more than 90 percent of unsaturated fatty acid, can effectively remove various free radicals generated by cell metabolism, and simultaneously combines and dissolves deposited lipid substances to keep the activity of skin cells.
The multiple plant extract composition is composed of golden chamomile extract, honeysuckle flower extract, pseudo-ginseng root extract, eucommia bark extract, glycyrrhiza glabra root extract and Glycyrrhiza flavonoid compound.
The composition of the invention also comprises 3-O-ethyl ascorbic acid, nicotinamide, PEG-20 methyl glucose sesquistearate, tocopheryl acetate, low molecular hyaluronic acid, inositol, and glycerol.
The composition containing peony extract and having whitening effect provided by the invention comprises the following components in parts by weight:
0.6-6 parts of peony extract, 0.05-4.1 parts of multiple plant extract composition, 0.1-1 part of 3-O-ethyl ascorbic acid, 0.5-5 parts of nicotinamide, 0.1-1 part of PEG-20 methyl glucose sesquistearate, 0.1-1 part of tocopheryl acetate, 0.05-0.5 part of low molecular hyaluronic acid, 0.5-3 parts of inositol and 2-8 parts of glycerin.
Preferably, in the peony extract, 0.5-5 parts of peony fresh petal squeezing stock solution and 0.1-1 part of peony seed oil are used.
Preferably, in the multiple plant extract composition, 0.01-1 part of chamomile extract, 0.01-1 part of honeysuckle extract, 0.01-1 part of pseudo-ginseng root extract, 0.01-1 part of eucommia bark extract, and 0.01-0.1 part of licorice root extract and licorice flavonoid compound.
Preferably, the Glycyrrhiza glabra root extract and the Glycyrrhiza flavonoid compound comprise 92% of Glycyrrhiza glabra root extract and 8% of Glycyrrhiza glabra flavonoid.
More preferably, the composition provided by the invention comprises the following components in parts by weight:
3 parts of peony fresh petal squeezing stock solution, 0.5 part of peony seed oil, 0.05 part of golden chamomile extract, 0.01 part of honeysuckle extract, 0.01 part of pseudo-ginseng root extract, 0.05 part of eucommia bark extract, 0.02 part of a complex of licorice root extract and licorice flavonoids, 0.5 part of 3-O-ethyl ascorbic acid, 3 parts of nicotinamide, 0.5 part of PEG-20 methyl glucose sesquistearate, 0.5 part of tocopheryl acetate, 0.1 part of low molecular hyaluronic acid, 1 part of inositol and 4 parts of glycerin.
The various raw material components involved in the invention are characterized by the following:
The 3-O-ethyl ascorbate ether is a vitamin C derivative, can easily enter the dermis layer through the stratum corneum, and can inhibit the generation of tyrosinase after entering the organism, so that the generation of melanin is inhibited, the biological effect of the vitamin C is exerted, and the effects of whitening and removing freckles are achieved.
Golden chamomile is called as "noble flower" in Latin, is regarded as "shenhua" from ancient times, contains rich flavonoid active ingredients, has good effects of relaxing sensitization, repairing sensitive skin, reducing red blood streaks, reducing redness, adjusting uneven skin color and the like, and has good soothing effect on skin easy to itch.
The eucommia bark contains rich gutta-percha, can bring natural viscosity, avoids skin sensitivity caused by adding components such as artificial thickening agent and the like into the composition such as cosmetics and the like for improving the product viscosity, and can improve the safety of the product.
The functional components of glabridin (Glabrene) and glabridin (Glabridin) which have strong antioxidant activity and are used for fading skin exist in tissue cells such as roots and rhizomes of glabridin, and the like, so that the whitening skin care composition can be matched with peony extract to achieve good sun-screening and whitening effects.
The composition containing the peony extract and having the whitening effect is obtained through freeze-drying treatment.
The composition containing the peony extract and having the whitening effect is prepared by the following method:
(1) Adding a formula amount of squeezed stock solution of fresh peony petals, peony seed oil, tocopheryl acetate and glycerol into a container, uniformly stirring, and marking as a solution I for later use;
(2) Adding deionized water, nicotinamide, flos Matricariae Chamomillae extract, flos Lonicerae extract, notoginseng radix root extract, and cortex Eucommiae extract into another container, stirring, and recording as solution II;
(3) Adding 10% -15% of the total amount of the solution II into the solution I, stirring for 4-5min to make the solution clear and transparent, and then continuously adding the rest of the solution II, and uniformly stirring for later use;
(4) Adding a licorice root extract and a licorice flavonoid compound, 3-O-ethyl ascorbic acid, PEG-20 methyl glucose sesquistearate, low-molecular hyaluronic acid and inositol into the solution obtained in the step (3), uniformly stirring, and marking as a solution III;
(5) Filling the solution III into a freeze-drying box, and then starting freeze-drying to obtain a composition;
the freeze-drying parameters are that the pre-freezing temperature is-60 to-40 ℃, the pre-freezing temperature is kept for 3-5 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 6-10 hours, the temperature of the partition board in the sublimation stage is 30-50 ℃, and the pressure is 10-20 Pa.
The freeze-dried composition provided by the invention can be used singly or compounded into a skin care product according to the addition amount of 10% -20%, and the dosage form of the skin care product can be any one of cream, milk, liquid, essence and facial mask.
The invention has the beneficial effects that:
(1) According to the composition containing the peony extract and having the whitening effect, the peony extract is matched with the 3-O-ethyl ascorbic acid, the tocopheryl acetate and the nicotinamide to serve as main whitening effect substances, on one hand, the characteristic that the tocopheryl acetate is oxidized by light is utilized to block direct contact of skin surface cells and light, and damage of ultraviolet rays to skin is reduced, on the other hand, the antioxidation and whitening effect of the peony extract are combined, and the 3-O-ethyl ascorbic acid, the tocopheryl acetate and the like are combined to inhibit the action activity of the aminopeptidase in the cells through penetrating into the skin, so that melanin generation is fundamentally reduced, and finally the skin whitening effect is achieved.
(2) The composition of the invention is also added with various natural plant extracts, low molecular hyaluronic acid and other components, and each plant extract contains rich flavone and flavonoid substances, so that the composition can assist in playing a proper role in moisturizing while whitening skin, is favorable for keeping skin compact and full in moisture, and further delays skin aging.
In addition, the inositol added in the invention is the growth factors of animals and microorganisms, and the inositol is added, so that the inositol can be synergistic with multiple natural plant extracts to further improve the activity of skin cells.
(3) According to the invention, a small amount of eucommia bark extract is added, the viscosity of a composition product is improved by using natural gutta-percha components contained in eucommia bark, and components such as a synthetic thickener, a tackifier and the like are not added in the composition, so that the production cost of the composition product is reduced, and the use safety of the product is improved.
(4) The peony extract adopted in the composition is peony fresh flower stock solution and micromolecular peony seed oil which is easy to be absorbed by skin, wherein the peony fresh flower stock solution is prepared by taking raw ecological high-quality peony fresh flowers as raw materials and adopting a physical cold pressing process, the peony seed oil is obtained by a supercritical carbon dioxide extraction technology, has no solvent residue, high safety coefficient and rich bioactive substances, contains more than 90 percent of unsaturated fatty acid, can penetrate into skin, effectively eliminates various free radicals generated by skin cell metabolism, and combines and dissolves deposited lipid substances to keep the activity of skin cells.
(5) The invention adopts a unique freeze-drying process to prepare the whitening composition, avoids the damage of the high-temperature operation of the traditional cosmetic preparation process to the components of the natural extract, can furthest exert the efficacy of bioactive substances in the extract, and further improves the overall efficacy of the composition product.
Detailed Description
The present invention will now be further described in connection with specific embodiments in order to enable those skilled in the art to better understand the invention.
The peony seed oil used in the embodiment of the invention is purchased from the Duuzepa biotechnology company, inc. of peony, and the unsaturated fatty acid content is 92.05%.
Example 1
Adding 3 parts of peony fresh petal squeezing stock solution, 0.5 part of peony seed oil, 0.5 part of tocopheryl acetate and 4 parts of glycerol into a container, uniformly stirring, and marking as a solution I for later use;
(2) Adding deionized water, 3 parts of nicotinamide, 0.05 part of golden chamomile extract, 0.01 part of honeysuckle extract, 0.01 part of pseudo-ginseng root extract and 0.05 part of eucommia bark extract into another container, uniformly stirring, and marking as solution II for later use;
(3) Adding the total 13% solution II into the solution I, stirring for 4min until the solution is clear and transparent, and continuing to add the rest solution II, and stirring uniformly for later use;
(4) Adding 0.02 part of a licorice root extract and a licorice flavonoid compound, 0.5 part of 3-O-ethyl ascorbic acid, 0.5 part of PEG-20 methyl glucose sesquistearate, 0.1 part of low molecular hyaluronic acid and 1 part of inositol into the solution obtained in the step (3), uniformly stirring, and marking as a solution III;
(5) Filling the solution III into a freeze-drying box, and then starting freeze-drying to obtain a composition;
The freeze-drying parameters are that the pre-freezing temperature is-50 ℃, the pre-freezing temperature is kept for 4 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 8 hours, the temperature of the partition board in the sublimation stage is 40 ℃, and the pressure is 15Pa.
Example 2
Adding 0.5 part of peony fresh petal squeezing stock solution, 0.1 part of peony seed oil, 0.1 part of tocopheryl acetate and 2 parts of glycerol into a container, uniformly stirring, and marking as a solution I for later use;
(2) Adding deionized water, nicotinamide 0.5 part, chamomile extract 0.01 part, honeysuckle extract 0.01 part, notoginseng root extract 0.01 part and eucommia bark extract 0.01 part into another container, stirring uniformly, and recording as solution II for later use;
(3) Adding the total 10% solution II into the solution I, stirring for 4min until the solution is clear and transparent, and continuing to add the rest solution II, and stirring uniformly for later use;
(4) Adding 0.01 part of a licorice root extract and licorice flavonoid compound, 0.1 part of 3-O-ethyl ascorbic acid, 0.1 part of PEG-20 methyl glucose sesquistearate, 0.05 part of low molecular hyaluronic acid and 0.5 part of inositol into the solution obtained in the step (3), uniformly stirring, and marking as a solution III;
(5) Filling the solution III into a freeze-drying box, and then starting freeze-drying to obtain a composition;
the freeze-drying parameters are that the pre-freezing temperature is-40 ℃, the pre-freezing temperature is kept for 3 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 6 hours, the temperature of the partition board in the sublimation stage is 30 ℃, and the pressure is 10Pa.
Example 3
Adding 5 parts of peony fresh petal squeezing stock solution, 1 part of peony seed oil, 1 part of tocopheryl acetate and 8 parts of glycerol into a container, uniformly stirring, and marking as a solution I for later use;
(2) Adding deionized water, nicotinamide 5 parts, chamomile extract 1 part, honeysuckle extract 1 part, pseudo-ginseng root extract 1 part and eucommia bark extract 1 part into another container, uniformly stirring, and marking as a solution II for later use;
(3) Adding the total 15% solution II into the solution I, stirring for 4min until the solution is clear and transparent, and continuing to add the rest solution II, and stirring uniformly for later use;
(4) Adding 0.1 part of a licorice root extract and licorice flavonoid compound, 1 part of 3-O-ethyl ascorbic acid, 1 part of PEG-20 methyl glucose sesquistearate, 0.5 part of low-molecular hyaluronic acid and 3 parts of inositol into the solution obtained in the step (3), uniformly stirring, and marking as a solution III;
(5) Filling the solution III into a freeze-drying box, and then starting freeze-drying to obtain a composition;
The freeze-drying parameters are that the pre-freezing temperature is minus 60 ℃, the pre-freezing temperature is kept for 5 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 10 hours, the temperature of the partition board in the sublimation stage is 50 ℃, and the pressure is 20Pa.
Example 4
The parts by weight of the components and the preparation steps are the same as in example 1, and only the freeze-drying process parameters of the composition are changed;
The specific freeze-drying process parameters are that the pre-freezing temperature is-40 ℃, the pre-freezing temperature is kept for 3 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 6 hours, the temperature of a partition board in a sublimation stage is 30 ℃, and the pressure is 10Pa.
Example 5
The parts by weight of the components and the preparation steps are the same as in example 1, and only the freeze-drying process parameters of the composition are changed;
The specific freeze-drying process parameters are that the pre-freezing temperature is minus 60 ℃, the pre-freezing temperature is kept for 5 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 10 hours, the temperature of a partition board in the sublimation stage is 50 ℃, and the pressure is 20Pa.
Example 6
The parts by weight of the components and the preparation steps are the same as in example 1, and only the freeze-drying process parameters of the composition are changed;
the specific freeze-drying process parameters are that the pre-freezing temperature is-45 ℃, the pre-freezing temperature is kept for 5 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 8 hours, the temperature of a partition board in a sublimation stage is 42 ℃, and the pressure is 18Pa.
Examples 7 to 12
Under the precondition that the freeze-drying process conditions of the composition product are the same as those of the example 1, only the parts by weight of each component in the composition are changed, and the parts by weight of each component in the raw materials of the composition are shown in the following table:
table 1 weight fraction of the components in examples 7 to 12
The product properties of examples 1-12 are shown in Table 2.
TABLE 2 product Performance cases for examples 1-12
As can be seen from the above table, the product obtained in each embodiment has a good texture, a mellow and non-pungent peony fragrance, a good application property to the skin, a good air permeability, no allergic abnormality after use, a good improvement effect on the darkness of the facial skin, and a whitening effect.
Comparative example 1
On the premise that the freeze-drying parameter conditions of the composition are the same as those of the example 1, only the content of multiple plant extracts in each component is changed, and the specific steps are as follows:
(1) Adding 3 parts of peony fresh petal squeezing stock solution, 0.5 part of peony seed oil, 0.5 part of tocopheryl acetate and 4 parts of glycerol into a container, uniformly stirring, and marking as a solution I for later use;
(2) Adding deionized water, 3 parts of nicotinamide, 2 parts of golden chamomile extract, 2 parts of honeysuckle extract, 3 parts of pseudo-ginseng root extract and 5 parts of eucommia bark extract into another container, uniformly stirring, and marking as a solution II for later use;
(3) Adding the total 13% solution II into the solution I, stirring for 4min until the solution is clear and transparent, and continuing to add the rest solution II, and stirring uniformly for later use;
(4) Adding 2 parts of a licorice root extract and a licorice flavonoid compound, 0.5 part of 3-O-ethyl ascorbic acid, 0.5 part of PEG-20 methyl glucose sesquistearate, 0.1 part of low molecular hyaluronic acid and 1 part of inositol into the solution obtained in the step (3), uniformly stirring, and marking as a solution III;
(5) And (5) filling the solution III into a freeze-drying box, and then starting freeze-drying to obtain the composition.
Comparative example 2
On the premise that the freeze-drying parameter conditions and steps of the composition are the same as those of the embodiment 1, only the content of the peony extract is changed, wherein 6 parts of fresh peony petal squeezing stock solution and 3 parts of peony seed oil are used.
Comparative example 3
On the premise that the freeze-drying parameter conditions and steps of the composition are the same as those of the embodiment 1, only the content of the peony extract is changed, wherein 3 parts of fresh peony petal squeezing stock solution and 6 parts of peony seed oil are used.
Comparative example 4
Under the condition that the freeze-drying parameters and the steps of the composition are the same as those of the example 1, only the content of the eucommia bark extract is changed, wherein the addition amount of the eucommia bark extract is 1.6 parts.
Comparative example 5
On the premise that the raw material components and the process steps (1) - (4) are completely the same as those of the embodiment 1, only the condition of freeze-drying operation is changed, wherein the freeze-drying parameters are that the prefreezing temperature is-15 ℃, the condition is kept for 4 hours after the prefreezing temperature reaches the stipulated prefreezing temperature, the drying time is 8 hours, the temperature of a partition board in a sublimation stage is 20 ℃, and the pressure is 15Pa.
Comparative example 6
On the premise that the raw material components and the process steps (1) - (4) are completely the same as those of the embodiment 1, only the freeze-drying process is changed into a high-pressure homogenizing process, and the technological parameters are 1000r/min and the homogenization is carried out for 2min.
Comparative example 7
The properties of the products obtained in comparative examples 1 to 6 were evaluated, and the results are shown in Table 3.
Table 3 conditions of the product properties of comparative examples 1 to 6
In addition to the results shown in the table, in fact, the final products of comparative examples 1-2 were more organoleptic irritating, and the peony was strongly fragrant, easily sneezed and connected to the people more sensitive to floral and aromatic, and the audience of the composition product was narrower than the product obtained in example 1.
The composition product obtained in comparative example 3 was greasy and less breathable than the product of example 1, and had poor adsorption to skin tissue.
The composition product obtained in comparative example 4 has a great improvement in adhesiveness as compared with the product of example 1, but when the product is tried on the skin, the contact with the skin is tighter, the difficulty in washing is greater, and the air permeability of the product is extremely poor, so that the addition amount of the eucommia bark extract must be controlled at a low level.
The product obtained in comparative example 5 was loose in texture, poor in fineness, possibly caused by a high temperature of the lyophilization process and a low degree of mixing of the product, and in addition, the study also found that the freezing effect did not show a large change under the condition of too low a lyophilization temperature, and the energy consumption was high, so that the temperature conditions of lyophilization cooling were limited to-60 to-40 ℃.
The product obtained in comparative example 6 has a strong smell, and in view of the fact that the raw materials used in the present invention, such as 3-O-ethyl ascorbic acid, are more sensitive to light and heat and contain more natural plant components, the product easily generates higher heat during high-pressure homogenization to inactivate part of the raw material components of the product, and further to impair the efficacy of the composition product, so that the present invention does not use high-pressure homogenization to prepare the product in order to avoid the raw materials in the product from being damaged or inactivated.
Claims (5)
1. A composition containing peony extract and having whitening effect is characterized by comprising peony extract and multiple plant extract compositions, wherein the peony extract is peony fresh flower petal squeezing stock solution and peony seed oil, and the multiple plant extract compositions are golden chamomile extract, honeysuckle extract, pseudo-ginseng root extract, eucommia bark extract, licorice root extract and licorice flavonoid compound;
the composition also comprises 3-O-ethyl ascorbic acid, nicotinamide, PEG-20 methyl glucose sesquistearate, tocopheryl acetate, low molecular hyaluronic acid, inositol, glycerol, and deionized water;
The weight portions of the components are as follows:
0.6 to 6 parts of peony extract, 0.05 to 4.1 parts of multiple plant extract composition, 0.1 to 1 part of 3-O-ethyl ascorbic acid, 0.5 to 5 parts of nicotinamide, 0.1 to 1 part of PEG-20 methyl glucose sesquistearate, 0.1 to 1 part of tocopheryl acetate, 0.05 to 0.5 part of low molecular hyaluronic acid, 0.5 to 3 parts of inositol and 2 to 8 parts of glycerol;
0.5-5 parts of peony fresh petal squeezing stock solution and 0.1-1 part of peony seed oil in the peony extract;
In the multiple plant extract composition, 0.01-1 part of golden chamomile extract, 0.01-1 part of honeysuckle extract, 0.01-1 part of pseudo-ginseng root extract, 0.01-1 part of eucommia bark extract, and 0.01-0.1 part of licorice root extract and licorice flavonoid compound;
in the glycyrrhiza glabra root extract and liquorice flavonoid compound, the glycyrrhiza glabra root extract accounts for 92 percent and the liquorice flavonoid accounts for 8 percent;
The composition is obtained by adopting a freeze-drying process;
the freeze-drying process comprises the specific operation method that the materials with the formula amount are put into a freeze-drying box and then freeze-dried, the pre-freezing temperature is-60 to-40 ℃, the pre-freezing temperature is kept for 3-5 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 6-10 hours, the temperature of a partition board in a sublimation stage is 30-50 ℃, and the pressure is 10-20 Pa.
2. The composition with whitening effect containing peony extract as claimed in claim 1, wherein the composition is characterized by comprising the following components in parts by weight:
3 parts of peony fresh petal squeezing stock solution, 0.5 part of peony seed oil, 0.05 part of golden chamomile extract, 0.01 part of honeysuckle extract, 0.01 part of pseudo-ginseng root extract, 0.05 part of eucommia bark extract, 0.02 part of a complex of licorice root extract and licorice flavonoids, 0.5 part of 3-O-ethyl ascorbic acid, 3 parts of nicotinamide, 0.5 part of PEG-20 methyl glucose sesquistearate, 0.5 part of tocopheryl acetate, 0.1 part of low molecular hyaluronic acid, 1 part of inositol and 4 parts of glycerin.
3. The composition with whitening effect containing peony extract according to claim 1, wherein the composition is prepared by the following method:
(1) Adding a formula amount of squeezed stock solution of fresh peony petals, peony seed oil, tocopheryl acetate and glycerol into a container, uniformly stirring, and marking as a solution I for later use;
(2) Adding deionized water, nicotinamide, flos Matricariae Chamomillae extract, flos Lonicerae extract, notoginseng radix root extract, and cortex Eucommiae extract into another container, stirring, and recording as solution II;
(3) Adding 10% -15% of the total amount of the solution II into the solution I, stirring for 4-5 min until the solution is clear and transparent, continuously adding the rest of the solution II, and uniformly stirring for later use;
(4) Adding a licorice root extract and a licorice flavonoid compound, 3-O-ethyl ascorbic acid, PEG-20 methyl glucose sesquistearate, low-molecular hyaluronic acid and inositol into the solution obtained in the step (3), uniformly stirring, and marking as a solution III;
(5) Filling the solution III into a freeze-drying box, and then starting freeze-drying to obtain a composition;
The freeze-drying parameters are that the pre-freezing temperature is-60 to-40 ℃, the pre-freezing temperature is kept for 3-5 hours after the pre-freezing temperature reaches the preset pre-freezing temperature, the drying time is 6-10 hours, the temperature of the partition board in the sublimation stage is 30-50 ℃, and the pressure is 10-20 Pa.
4. The composition with whitening effect containing peony extract according to claim 1, wherein the composition can be used alone or compounded into skin care products according to the addition amount of 10% -20%.
5. The composition with whitening effect containing peony extract according to claim 4, wherein the skin care product is in the form of any one of cream, milk, lotion, essence and facial mask.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310602676.7A CN116549353B (en) | 2023-05-26 | 2023-05-26 | Composition with whitening effect containing peony extract and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310602676.7A CN116549353B (en) | 2023-05-26 | 2023-05-26 | Composition with whitening effect containing peony extract and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116549353A CN116549353A (en) | 2023-08-08 |
| CN116549353B true CN116549353B (en) | 2025-01-28 |
Family
ID=87489747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310602676.7A Active CN116549353B (en) | 2023-05-26 | 2023-05-26 | Composition with whitening effect containing peony extract and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116549353B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679641A (en) * | 2021-09-28 | 2021-11-23 | 山东派恩生物科技有限公司 | Mask added with peony extract and preparation method thereof |
| CN115105446A (en) * | 2022-06-28 | 2022-09-27 | 菏泽职业学院 | Oil peony whitening mask and preparation method thereof |
| CN115154383A (en) * | 2022-07-08 | 2022-10-11 | 泉后(广州)生物科技研究院有限公司 | Mild whitening composition and whitening cream thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110051593A (en) * | 2019-05-28 | 2019-07-26 | 西安量木生态科技有限公司 | A kind of peony essence dew and preparation method thereof |
| CN110664635B (en) * | 2019-11-05 | 2021-05-07 | 湖北创界生物科技有限公司 | Moisturizing and hydrating mask composition, mask and preparation method of mask |
| EP4267090A1 (en) * | 2020-12-23 | 2023-11-01 | L V M H Recherche | Cosmetic composition comprising an aqueous or an hydroalcoholic extract of peony |
| CN113143826A (en) * | 2021-05-17 | 2021-07-23 | 山东派恩生物科技有限公司 | Antioxidant moisturizing sleeping mask containing peony flower stock solution and preparation method thereof |
| CN114533609A (en) * | 2022-01-25 | 2022-05-27 | 北京妍之素生物科技有限公司 | Repairing freeze-dried mask and preparation method thereof |
-
2023
- 2023-05-26 CN CN202310602676.7A patent/CN116549353B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679641A (en) * | 2021-09-28 | 2021-11-23 | 山东派恩生物科技有限公司 | Mask added with peony extract and preparation method thereof |
| CN115105446A (en) * | 2022-06-28 | 2022-09-27 | 菏泽职业学院 | Oil peony whitening mask and preparation method thereof |
| CN115154383A (en) * | 2022-07-08 | 2022-10-11 | 泉后(广州)生物科技研究院有限公司 | Mild whitening composition and whitening cream thereof |
Non-Patent Citations (1)
| Title |
|---|
| 冷冻干粉制剂在化妆品中的应用;高斌;第十三届东南亚地区医学美容学术大会;20111230;第176-178页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116549353A (en) | 2023-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20170281988A1 (en) | Skin Care and Cosmetic Composition | |
| KR101315265B1 (en) | Cosmetic composition for improving skin senescence | |
| KR101860307B1 (en) | Cosmetic composition for moisturizing skin containing water-soluble silicon | |
| CN104825382A (en) | Biotechnology skin-whitening cosmetics | |
| CN110664650A (en) | Multi-effect skin care composition and essence and preparation method thereof | |
| CN107937176A (en) | A kind of high-efficiency antioxidant anti-acne handmade soap | |
| CN111973481A (en) | Blue ketone peptide repair essence and preparation method thereof | |
| CN106309340A (en) | Grapefruit juice anti-wrinkle skin care formula | |
| CN109771348B (en) | Whitening, moisturizing and wrinkle-removing cream rich in natural product extract components and preparation method thereof | |
| KR20230152511A (en) | Cosmetic composition in relieving skin for skin regenerating, Manufacturing method thereof, and Cosmetics containing the same | |
| KR101397160B1 (en) | Cosmetic compositon for skin-irritation alleviation with Inula britannica var. chinensis, Cynanchi Radix and Lysimachia foenum-graecum Hance | |
| CN110251448A (en) | A kind of cosmetic compositions containing propolis extract | |
| CN108498445A (en) | A kind of novel anti-aging type Essence | |
| CN104971015A (en) | Facial mask product special for oily skin and preparation method thereof | |
| CN108721192B (en) | A kind of natural plant extract essence facial mask liquid and its extraction process | |
| CN115024991A (en) | Anti-aging composition and preparation method and application thereof | |
| CN114306188B (en) | Preparation method of whitening and anti-inflammatory facial mask liquid | |
| CN112716838A (en) | Rose essential oil eye repairing and tightening essence and preparation method thereof | |
| CN112472629A (en) | Alpinia officinarum and amomum tsao-ko sun-proof emulsion and preparation method thereof | |
| CN112057386A (en) | Refreshing, moisturizing, whitening and repairing sun block and preparation method thereof | |
| WO2015010372A1 (en) | Cream used for treatment of acne hyperpigmentation spot and for whitening | |
| CN108938511B (en) | Composition of natural plant extracts and application of composition in skin moisturizing and acne removing products | |
| CN111973544A (en) | Carnosine firming lifting mask and preparation method thereof | |
| CN111973496A (en) | Seaweed moisturizing mask and preparation method thereof | |
| CN116549353B (en) | Composition with whitening effect containing peony extract and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |