CN103271850A - Method for preparing bacteriostatic bath foam from pepper extract - Google Patents
Method for preparing bacteriostatic bath foam from pepper extract Download PDFInfo
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- CN103271850A CN103271850A CN201310178652XA CN201310178652A CN103271850A CN 103271850 A CN103271850 A CN 103271850A CN 201310178652X A CN201310178652X A CN 201310178652XA CN 201310178652 A CN201310178652 A CN 201310178652A CN 103271850 A CN103271850 A CN 103271850A
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- 239000006260 foam Substances 0.000 title claims abstract description 34
- 230000003385 bacteriostatic effect Effects 0.000 title abstract description 5
- 238000000034 method Methods 0.000 title abstract description 4
- 229940116257 pepper extract Drugs 0.000 title abstract 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 24
- 238000003756 stirring Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 9
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 6
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 239000000284 extract Substances 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 11
- 239000012071 phase Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 10
- 238000001816 cooling Methods 0.000 abstract description 5
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract description 3
- 241000588724 Escherichia coli Species 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 229960003237 betaine Drugs 0.000 abstract description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 201000002266 mite infestation Diseases 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 10
- 239000003921 oil Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 238000011161 development Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 230000009514 concussion Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 230000001408 fungistatic effect Effects 0.000 description 3
- HIDKSOTTZRMUML-UHFFFAOYSA-M potassium;dodecanoate Chemical compound [K+].CCCCCCCCCCCC([O-])=O HIDKSOTTZRMUML-UHFFFAOYSA-M 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 241001145009 Sophora alopecuroides Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- -1 fatty acid salt Chemical class 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003348 petrochemical agent Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention relates to a method for preparing bacteriostatic bath foam from a pepper extract. The method comprises the following steps of: dissolving 0.1 % of EDTA-2Na and 1 to 7 % of potassium hydroxide into deionized water and heating to 85 DEG C to obtain a spare water phase; mixing 3 to 10 % of dodecanoic acid, 4 to 15 % of tetradecanoic acid and 1 to 2 % of ethylene glycol distearate and heating to 85 DEG C to obtain a spare oil phase; and adding the oil phase into the water phase, mixing and stirring until the mixture is transparent, adding 10 to 40 % of the pepper extract, 0 to 3 % of alkanolamide and 10 to 35 % of 35 % cocanidoproryl betaine alkali solution, stirring and cooling to below 50 DEG C, adding essence and a preservative, adjusting the pH value to be 6-7, continuously stirring and cooling to 40 DEG C, and outputting to obtain the product. The bacteriostatic bath foam containing the pepper extract has a certain bacteriostatic effect on escherichia coli, staphylococcus aureus and the like, has an effect of preventing eczema, pruritus, mange and the like, and has a certain effect of nourishing skin. The bath foam is simple in formula and can meet the natural, environmentally-friendly and efficiently antibacterial basic requirements of the modern markets.
Description
Technical field
The present invention relates to a kind of antibacterial type bath foam of natural extract, relate in particular to a kind of Folium Zanthoxyli Bungeani extract antibacterial type bath foam.
Background technology
Bath foam is the necessary of people's daily life, as fluid product, be characterized in to allocate into various functional raw materials, Transdermal absorption by effective ingredient, improve the microcirculation situation of skin, strengthen the disease-resistant and repair ability of skin, reach the multipurpose of cleaning skin, nursing skin, promotion skin health.
Constantly perfect along with article of everyday use, the bath foam product of plant extract type is subjected to liking of consumers in general deeply.The bath foam prescription of various antibacterial types is applied patent and delivers document.
Application number: the production method main processes of 200910175652.8 sophora alopecuroide bacteriostatic bath foams is extracted extracting solution with Cornu Cervi Pantotrichum, Radix Ginseng Flos Caryophylli, Radix Angelicae Sinensis; To extract medicinal liquid mixes, add Radix Sophorae Flavescentis total alkaloids extractum and become the Chinese medicine admixing medical solutions, add deionized water, add hydroxyethyl-cellulose, stir, heating also adds sodium lauryl sulphate, cocoanut fatty acid diethanolamide, polyoxyethylenated alcohol sodium sulfate, Pearl Concentrate stirring and dissolving, rise to uniform temperature, stirring is waited to dissolve, and the cooling back adds acetylbutyrylcellulose, glycerol stirs, and being up to the standards is finished product.
Application number: 201110452222.3 kinds of antibiotic nourishing bath foam of Chinese medicine and preparation method thereof, being to be raw material by 25 ~ 35 weight portion Radix Sophorae Flavescentiss, 15 ~ 25 weight portion Cortex Phellodendris, 25 ~ 35 weight portion Radix Gentianaes, 15 ~ 25 weight portion Fructus Cnidiis, 15 ~ 25 weight portion Rhizoma Smilacis Glabraes, is the Chinese medicine extraction liquid that extracting solution extracts the d=1.5～1.8g/ml that obtains with water.The antibiotic nourishing bath foam of Chinese medicine of the present invention has certain fungistatic effect to escherichia coli, staphylococcus aureus, Candida albicans.
By Wu Jianguo, the development of the Folium Zanthoxyli Bungeani bath foam that researchs such as Tan Qun are delivered, be published in Speciality Petrochemicals make progress the 13rd the volume the 8th phase document periodical, mainly having studied with the Folium Zanthoxyli Bungeani extract is the Pericarpium Zanthoxyli bath foam that raw material makes, preparation process is for adding people's AESA successively under the deionized water heated and stirred, lauryl alcohol ammonium sulfate, Oleum Cocois diethanol phthalein amine, lauryl phosphoric acid vinegar potassium salt, alkyl glucose former times, cocos nucifera oil phthalein amine CAB and E D TA disodium, the cooling of dissolving back fully, add people's Folium Zanthoxyli Bungeani extract, regulate p H to 6-7, stirring is cooled to below 45 ℃, adds people's antiseptic and essence, continue to stir cooling, make product.
Folium Zanthoxyli Bungeani is the by-product in the Pericarpium Zanthoxyli plantation, and development Folium Zanthoxyli Bungeani bath foam can develop a large amount of discarded Pericarpium Zanthoxyli branch and leaf, for the agricultural economy band considerable economic.The chemical constituent of Folium Zanthoxyli Bungeani is similar to peel, extract mainly contains volatile oil, alkaloid, flavone etc., experimental results show that the Folium Zanthoxyli Bungeani extract is to staphylococcus aureus, bacillus subtilis and escherichia coli all have fungistatic effect, and are especially obvious to staphylococcus aureus and bacillus subtilis effect, the application of exploitation Folium Zanthoxyli Bungeani in bath article, both complied with the trend that cosmetics develop to natural chemotherapy effectization direction, can satisfy consumer again to skin care, cleaning, the needs of nursing.
Summary of the invention
The invention provides the antibacterial bath foam preparation method of a kind of Fructus Zanthoxyli extract, not only production cost is low, fungistatic effect is obvious, and a large amount of discarded Pericarpium Zanthoxyli branch and leaf of development and use can promote agro based economic development.
The antibacterial bath foam preparation method of a kind of Fructus Zanthoxyli extract is dissolved in EDTA-2Na 0.1%, potassium hydroxide 1% ~ 7% in the deionized water, is heated to 85 ℃, is water; Dodecoic acid 3% ~ 10%, tetradecylic acid 4% ~ 15%, ethylene glycol distearate 1% ~ 2% are mixed, be heated to 85 ℃, be oil phase; Oil phase is added aqueous phase, mix and stir, until transparent, add Fructus Zanthoxyli extract 10 ~ 40%, alkanolamide 0 ~ 3%, 35% cocamido propyl betaine solution 10% ~ 35%, stirring is cooled to below 50 ℃, adds an amount of essence and antiseptic, regulate p H to 6-7, continue to stir to be cooled to 40 ℃, discharging is product again.
In dodecoic acid, tetradecylic acid and the potassium hydroxide and generate potassium dodecanoate, tetradecylic acid potassium surfactant, it is the foaming agent of bath foam.Increase the frothing capacity that fatty acid salt content can obviously improve bath foam, the frothing capacity of potassium dodecanoate is better slightly than tetradecylic acid potassium, but zest is bigger slightly than tetradecylic acid potassium, and the price of tetradecylic acid is more more than dodecoic acid height, so the consumption of the two should be determined by product price.Potassium hydroxide is as nertralizer, and its consumption is advisable to control about product pH=7.Potassium dodecanoate, tetradecylic acid potassium detergency ability are better, and be very easy to flushing, have overcome the shortcoming that bath foam has soapy feeling.
35% cocamido propyl betaine solution is the betaine type amphoteric surfac-tant, have washing and conditioning effect, zest is low, add the zest that can reduce anion surfactant in the prescription, anion surfactant there is certain thickening effect, and having stable foam effect preferably, its consumption should be decided according to bath foam type and effect.Alkanolamide mainly plays thickening and steady bubble effect in prescription, its consumption is advisable with about 3%.
The best in quality formula proportion that the present invention selects for use is: dodecoic acid 8.5%; Tetradecylic acid 4.5%; Potassium hydroxide 3.8%; 35% cocamido propyl betaine solution 30%; Alkanolamide 3%; Ethylene glycol distearate 1.5%; EDTA-2Na 0. 1%; Fructus Zanthoxyli extract 40%; Antiseptic, essence each 0.1%; Deionized water is an amount of.
The preparation of Folium Zanthoxyli Bungeani extract: the pericarpium zanthoxyli bungeani leaf is pulverized, press solid-liquid ratio 1g: 25ml and add the methanol of concentration 50% as extractant, concussion at room temperature, separation of supernatant, and will obtain extractum after the supernatant concentration drying, and extractum is scattered in the purified water, solid-liquid ratio is 1g: 40ml, add normal hexane concussion extraction then, collect the water extract; Again the water raffinate is added chloroform, the water raffinate is collected in the concussion extraction; Then the water raffinate is added ethyl acetate in right amount, the concussion extraction, concentrate drying gets extract.
Folium Zanthoxyli Bungeani extract and surfactant compatibility are good, and maximum addition can reach 40%, do not influence physical and chemical index and the performance of bath foam product substantially.Folium Zanthoxyli Bungeani is got thing and is had tangible antipruritic effect for bath foam, and to the treatment erythra, it is all-natural product that certain effect Folium Zanthoxyli Bungeani extract is also arranged, have no side effect, use safety, the Folium Zanthoxyli Bungeani extract is used for bath foam, has complied with the trend of the market of cosmetics to naturalization and curative effect development.Also take full advantage of discarded Folium Zanthoxyli Bungeani simultaneously and opened up a new developing direction for agricultural.
Involved in the present invention to the unit of component percentage ratio be mass percent (wt%)
The kind of the antiseptic of described essence and consumption can be selected and add according to the pharmaceutical field common practise.
Embodiment 1 is dissolved in EDTA-2Na 0. 1%, potassium hydroxide 3.8% in the deionized water, is heated to 85 ℃, is water; Dodecoic acid 8.5%, tetradecylic acid 4.5%, ethylene glycol distearate 1.5% are mixed, be heated to 85 ℃, be oil phase; Oil phase is added aqueous phase, mix and stir, until transparent, add Fructus Zanthoxyli extract 40%, alkanolamide 3%, 35% cocamido propyl betaine solution 30%, stirring is cooled to below 50 ℃, adds an amount of essence and antiseptic, regulate p H to 6-7, continue to stir to be cooled to 40 ℃, discharging is product again.Bacteriostasis rate reaches 99%
Embodiment 2 is dissolved in EDTA-2Na 0. 1%, potassium hydroxide 3.8% in the deionized water, is heated to 85 ℃, is water; Dodecoic acid 8.5%, tetradecylic acid 4.5%, ethylene glycol distearate 1.5% are mixed, be heated to 85 ℃, be oil phase; Oil phase is added aqueous phase, mix and stir, until transparent, add Fructus Zanthoxyli extract 10%, alkanolamide 3%, 35% cocamido propyl betaine solution 30%, stirring is cooled to below 50 ℃, adds an amount of essence and antiseptic, regulate p H to 6-7, continue to stir to be cooled to 40 ℃, discharging is product again.Bacteriostasis rate reaches 89%.
Embodiment 1 proof test
1. toxicity test
Select the healthy mice of body weight 20-25g, male and female half and half are divided into 2 times ~ 3 times and give the Pericarpium Zanthoxyli bath foam liquid that accumulated dose is 20g/kg in 24 h, adopt administration by gavage, are inserted into the white mouse gastric with syringe and inject.Observed seven days continuously, abnormal symptom is not seen in none death of white mice.Result of the test shows, stock solution to the LD50 of male and female white mice all greater than 20g/kg, the nontoxic level in true border.
2. recruitment evaluation
Choose 40 volunteers the Folium Zanthoxyli Bungeani bath foam is tried out, trial periods 30 d uses the Folium Zanthoxyli Bungeani bath foam weekly 2-3 time, collects the evaluation that the experimenter suppresses, bathes the pleasant sense in back, dispels projects such as erythra de-sludging performance, skin pruritus,
Result on trial shows that Folium Zanthoxyli Bungeani bath foam detergency is strong, and foam is abundant, and antipruritic effect is obvious, after the bathing dermal sensation pleasant, and the treatment erythra also had certain effect.
Pericarpium Zanthoxyli bath foam result on trial
| Test event | Experimenter's number | Effective number | Effective percentage |
| The de-sludging performance | 40 | 40 | 100.0% |
| Skin pruritus suppresses | 40 | 28 | 93.3% |
| Bathe the pleasant sense in back | 40 | 39 | 97.5% |
| Dispel erythra | 40 | 36 | 90.0% |
Claims (2)
1. preparation method that Fructus Zanthoxyli extract is the antibacterial bath foam of raw material is characterized in that step is as follows:
1) EDTA-2Na 0. 1wt%, potassium hydroxide 1wt% ~ 7%wt are dissolved in the deionized water, are heated to 85 ℃, obtain standby water;
2) dodecoic acid 3wt% ~ 10wt%, tetradecylic acid 4wt% ~ 15wt%, ethylene glycol distearate 1wt% ~ 2wt% are mixed, be heated to 85 ℃, obtain standby oil phase;
3) oil phase is added aqueous phase, mix and stir, until transparent, add Fructus Zanthoxyli extract 10 ~ 40wt%, alkanolamide 0 ~ 3wt% and greater than 0,35% cocamido propyl betaine solution 10wt% ~ 35wt%, stir and be cooled to below 50 ℃, add essence and antiseptic, regulate p H to 6-7, continue to stir to be cooled to 40 ℃, discharging is product again.
2. be the preparation method of the antibacterial bath foam of raw material according to the described Fructus Zanthoxyli extract of claim 1, it is characterized in that described Fructus Zanthoxyli extract consumption is 40%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310178652.XA CN103271850B (en) | 2013-05-15 | 2013-05-15 | Method for preparing bacteriostatic bath foam from pepper extract |
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| CN201310178652.XA CN103271850B (en) | 2013-05-15 | 2013-05-15 | Method for preparing bacteriostatic bath foam from pepper extract |
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| CN103271850B CN103271850B (en) | 2015-06-03 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259018A (en) * | 2018-10-24 | 2019-01-25 | 中国科学院兰州化学物理研究所 | The Preparation method and use of extractive of general flavone with health care function in a kind of bunge pricklyash leaf |
| CN113797135A (en) * | 2021-10-25 | 2021-12-17 | 广州好迪集团有限公司 | Bath foam with antibacterial and antipruritic functions and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559380A (en) * | 2004-03-08 | 2005-01-05 | 浙江大学 | massage bath salt |
| CN1633985A (en) * | 2004-11-01 | 2005-07-06 | 江苏隆力奇生物科技股份有限公司 | Easy Rinse Moisturizing Body Wash |
-
2013
- 2013-05-15 CN CN201310178652.XA patent/CN103271850B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559380A (en) * | 2004-03-08 | 2005-01-05 | 浙江大学 | massage bath salt |
| CN1633985A (en) * | 2004-11-01 | 2005-07-06 | 江苏隆力奇生物科技股份有限公司 | Easy Rinse Moisturizing Body Wash |
Non-Patent Citations (1)
| Title |
|---|
| 巫建国等: "花椒叶沐浴液的研制", 《精细石油化工进展》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259018A (en) * | 2018-10-24 | 2019-01-25 | 中国科学院兰州化学物理研究所 | The Preparation method and use of extractive of general flavone with health care function in a kind of bunge pricklyash leaf |
| CN113797135A (en) * | 2021-10-25 | 2021-12-17 | 广州好迪集团有限公司 | Bath foam with antibacterial and antipruritic functions and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103271850B (en) | 2015-06-03 |
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