CN113797135A - Bath foam with antibacterial and antipruritic functions and preparation method thereof - Google Patents
Bath foam with antibacterial and antipruritic functions and preparation method thereof Download PDFInfo
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Abstract
The invention discloses bath foam with antibacterial and itching relieving functions and a preparation method thereof, wherein the bath foam contains a functional composition, and the functional composition comprises the following components in percentage by mass: 0.1-5% of pepper extract, 0.1-5% of keratin and 0.01-0.5% of trehalose. The preparation method of the bath foam comprises: the components of the bath foam are proportioned according to the mass percentage, firstly, 80-92% of pure water by mass is added into a container with a stirrer, then, a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride are added into the container, the container is heated from room temperature to 60-80 ℃ under normal pressure while stirring, the temperature is kept at a constant temperature while stirring, when the added raw materials are completely dissolved, the container is cooled to 40-30 ℃, then, the pepper extract, trehalose, keratin and the rest pure water are added into the container, the container is kept at a constant temperature while stirring at 40-30 ℃, and when the pepper extract, the trehalose and the keratin are completely dissolved, the bath foam with the functions of bacteriostasis and itching relieving is obtained by naturally cooling to room temperature.
Description
Technical Field
The invention belongs to the field of bath foam, and particularly relates to bath foam with antibacterial and itching relieving functions on skin and a preparation method thereof.
Background
With the improvement of the quality of life of people, people want to have healthy and beautiful skin, but due to the influence of environment, weather and the like, the skin is easy to lack nutrition, dry, inflamed, itchy and the like, so that the functional bath products are increasingly emphasized. Chinese patent application with publication number CN108158893A discloses an itching relieving shower gel, which is prepared from the following raw materials in parts by weight: 4-13 parts of honeysuckle, 20-35 parts of mint, 5-8 parts of mineral salt, 5-12 parts of tea polyphenol, 5-7 parts of glycerol, 5-10 parts of thickening agent, 15-20 parts of coconut oil acid alkanolamide, 15-20 parts of octyl dodecanol isostearate, 20-35 parts of deionized water and 12-17 parts of sodium laureth sulfate; has antibacterial and antipruritic effects. Chinese patent application with publication number CN110354036A discloses a composition for preparing coptis chinensis bath foam, a preparation method and application thereof, wherein the composition comprises the following components: water, surfactant, glycerol, polyquaternium-10, menthol, sodium chloride, preservative, pH regulator, complexing agent, rhizoma coptidis standard extract, mint extract and essence; has effects in eliminating acne (back), relieving inflammation, whitening skin, keeping moisture and moisturizing. Although the varieties of the existing bath foam are continuously increased and have the characteristics, the requirements of people in different areas, different age groups and different skin types are still difficult to meet.
Disclosure of Invention
The invention aims to provide novel bath foam with bacteriostasis and itching relieving functions on skin and a preparation method thereof, so as to increase the variety of the bath foam.
The bath foam with the antibacterial and itching relieving functions contains a functional composition, and the components of the functional composition and the mass fraction of each component in the bath foam are as follows: 0.1 to 5 percent of pepper extract, 0.1 to 5 percent of keratin and 0.01 to 0.5 percent of trehalose.
The bath foam with the antibacterial and itching relieving functions also comprises the following components in percentage by mass:
in the bath foam with the antibacterial and antipruritic functions, the zanthoxylum bungeanum extract is prepared by taking petroleum ether as an extractant and distilling and concentrating an extracting solution obtained by circularly extracting or leaching crushed zanthoxylum bungeanum at 40-70 ℃ under normal pressure, wherein the distilling and concentrating time is determined by that the volume fraction of the petroleum ether is less than 5%; the keratin is hydrolyzed keratin with molecular weight less than or equal to 200000 daltons, and can be purchased from the market or prepared by self.
The hydrolyzed keratin can be prepared by the following method:
cleaning animal hair with tap water, putting the cleaned animal hair into sodium thioglycolate alkali solution (adjusted by NaOH solution) with the pH value of 8-12 and the concentration of 0.3-1.0 mol/L, soaking for 1-3 hours at normal pressure and room temperature, then adding urea (the adding amount of the urea is limited by the concentration of 6.0-8.0 mol/L), reacting for 3-28 hours at normal pressure and 20-60 ℃, filtering undissolved raw materials after the reaction time expires, centrifugally separating to obtain keratin solution, respectively putting the obtained keratin solution into dialysis bags with the molecular weight cutoff of 200kD, dialyzing for 40 hours in mercaptoethanol aqueous solution with the mass concentration of 0.08%, and freeze-drying to obtain hydrolyzed keratin white powder with the molecular weight of less than or equal to 0 Dalton.
In the bath foam with antibacterial and antipruritic functions, the main surfactant is at least two of ammonium laureth sulfate, sodium lauroyl sarcosinate, potassium cocoyl glycinate, sodium lauroyl glutamate, disodium laureth sulfosuccinate, potassium laurate, potassium myristate, potassium palmitate, potassium stearate and potassium laureth phosphate; the auxiliary surfactant is at least two of cocamide DEA, cocamide MEA, cocamide methyl MEA, cocamide propyl betaine, lauramidopropyl hydroxysultaine, ethylene glycol distearate, lauryl glucoside and sodium lauroamphoacetate; the pH regulator is at least one of citric acid, sodium citrate, EDTA disodium and lactic acid; the pure water is deionized water or distilled water.
The preparation method of the bath foam with the functions of bacteriostasis and relieving itching comprises the steps of firstly adding 80-92% of pure water by mass into a container with a stirrer according to the components of the bath foam and the ingredients of the bath foam by mass percent, then adding the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride into a container with a stirrer, heating to 60-80 deg.C under normal pressure while stirring, cooling to 40-30 deg.C when the main surfactant, auxiliary surfactant, acid-base regulator and sodium chloride are completely dissolved, adding fructus Zanthoxyli extract, trehalose, keratin and residual pure water into a container with stirrer, stirring at 40-30 deg.C, and when the pepper extract, the trehalose and the keratin are completely dissolved, naturally cooling to room temperature to obtain the bath foam with the functions of bacteriostasis and relieving itching.
Compared with the prior art, the invention has the following beneficial effects:
1. since the bath foam of the present invention contains a functional composition consisting of zanthoxylum bungeanum maxim extract, keratin and trehalose, it is effective in suppressing skin inflammatory reaction (see example 11).
2. The bath foam has certain bacteriostasis because the bath foam contains a functional composition consisting of pepper extract, keratin and trehalose (see example 12).
3. Since the bath foam of the present invention contains a composition comprising zanthoxylum bungeanum maxim extract, keratin and trehalose, it has a certain inhibitory effect on skin rash, thereby relieving or eliminating itch caused by skin rash (see example 13).
4. The bath foam also has the functions of promoting skin blood circulation, enhancing skin nutrition and keeping skin elasticity.
5. The bath foam has the advantages of easily available raw materials and simple preparation method, thereby being convenient for industrial production.
Detailed Description
The bath foam with bacteriostatic and antipruritic functions and the preparation method thereof are further described by the following examples.
In the following embodiments, the pepper extract is prepared by using commercially available pepper as a raw material by the following method: the method comprises the steps of taking petroleum ether as an extracting agent, circularly extracting crushed Chinese prickly ash at the normal pressure and the temperature of 60 ℃ (the proportion of the Chinese prickly ash to the petroleum ether is 1 kg/20L, and the time is 2 hours) to obtain an extracting solution, and then distilling and concentrating the extracting solution to obtain the Chinese prickly ash extract with the volume fraction of the petroleum ether being 4%.
Except pepper extract, hydrolyzed keratin with molecular weight less than or equal to 200000 dalton, trehalose, a main surfactant, an auxiliary surfactant, an acid-base regulator and the like are purchased from the market.
Example 1
In this example, the bath foam comprises the following components (raw materials) by mass:
0.1kg of the pepper extract is extracted,
5kg of the keratin is hydrolyzed by the keratin-hydrolyzing agent,
0.5kg of trehalose is added into the sugar,
primary surfactant: 7.5kg of ammonium laureth sulfate,
cosurfactant: 1.0kg of cocamide DEA, 1.0kg of cocamide MEA,
acid-base regulator: 0.1kg of citric acid is added,
0.1kg of sodium chloride is added,
77.2kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into a water phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating the mixture from room temperature to 80 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 40 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 7.2kg of deionized water into the water phase pot, stirring the mixture at constant temperature of 40 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 2
In this example, the bath foam comprises the following components (raw materials) by mass:
0.5kg of the pepper extract is extracted,
4.3kg of the hydrolyzed keratin is added,
0.44kg of trehalose is added into the sugar,
primary surfactant: 7.0kg of sodium laureth sulfate, 6.9kg of sodium laureth sulfate,
cosurfactant: ethylene glycol distearate 1.2kg, cocamide methyl MEA 1.2kg,
acid-base regulator: 0.14kg of sodium citrate is added,
0.2kg of sodium chloride is added,
78.12kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into an aqueous phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the aqueous phase pot, heating the mixture from room temperature to 70 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 40 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 8.12kg of deionized water into the aqueous phase pot, stirring the mixture at constant temperature of 40 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 3
In this example, the bath foam comprises the following components (raw materials) by mass:
1.0kg of the pepper extract is added,
3.9kg of the hydrolyzed keratin is added,
0.39kg of trehalose is added into the sugar,
primary surfactant: 6.4kg of sodium lauroyl sarcosinate, 6.4kg of sodium lauroyl glutamate,
cosurfactant: 1.4kg of cocamidopropyl betaine, 1.3kg of lauramidopropyl hydroxysultaine,
acid-base regulator: 0.19kg of EDTA is added into the mixture,
0.3kg of sodium chloride is added,
78.72kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into a water phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating the mixture from room temperature to 60 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 35 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 8.72kg of deionized water into the water phase pot, stirring the mixture at constant temperature of 35 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 4
In this example, the bath foam comprises the following components (raw materials) by mass:
1.6kg of the pepper extract is extracted,
3.1kg of the hydrolyzed keratin is added,
0.32kg of trehalose is added into the sugar,
primary surfactant: 3.9kg of sodium laureth sulfate, 3.9kg of sodium lauroyl glutamate and 3.9kg of potassium laurate,
cosurfactant: 1.6kg of lauryl glucoside, 1.5kg of sodium lauroamphoacetate,
acid-base regulator: 0.24kg of EDTA disodium is added,
0.4kg of sodium chloride is added,
79.54kg of distilled water;
the preparation method comprises the following steps: adding 70kg of distilled water into a water phase pot, adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating from room temperature to 80 ℃ under normal pressure while stirring, stirring at constant temperature, cooling to 40 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, adding the pepper extract, trehalose, hydrolyzed keratin and the rest 9.54kg of distilled water into the water phase pot, stirring at constant temperature of 40 ℃, and naturally cooling to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 5
In this example, the bath foam comprises the following components (raw materials) by mass:
2.1kg of the pepper extract is extracted,
2.6kg of the keratin is hydrolyzed,
0.27kg of trehalose is added into the sugar,
primary surfactant: 3.5kg of coconut acyl potassium glycinate, 3.5kg of coconut acyl sodium glycinate and 3.6kg of potassium palmitate,
cosurfactant: 1.1kg of cocamidopropyl betaine, 1.1kg of lauramidopropyl hydroxysultaine, 1.2kg of lauryl glucoside,
acid-base regulator: 0.28kg of lactic acid was added,
0.5kg of sodium chloride is added,
80.25kg of distilled water;
the preparation method comprises the following steps: adding 70kg of distilled water into a water phase pot, adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating from room temperature to 60 ℃ under normal pressure while stirring, stirring at constant temperature, cooling to 40 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, adding the pepper extract, trehalose, hydrolyzed keratin and the rest 10.25kg of distilled water into the water phase pot, stirring at constant temperature of 40 ℃, and naturally cooling to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 6
In this example, the bath foam comprises the following components (raw materials) by mass:
2.7kg of the pepper extract,
2.2kg of the keratin is hydrolyzed,
0.21kg of trehalose is added into the sugar,
primary surfactant: sodium lauroyl glutamate 3.1kg, potassium lauryl phosphate 3.2kg, potassium myristate 3.2kg,
cosurfactant: cocamide MEA, 1.9kg, cocamide methyl MEA 1.8kg,
acid-base regulator: 0.16kg of citric acid, 0.16kg of sodium citrate,
0.6kg of sodium chloride is added,
80.77kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into a water phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating the mixture from room temperature to 80 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 30 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 10.77kg of deionized water into the water phase pot, stirring the mixture at constant temperature of 30 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 7
In this example, the bath foam comprises the following components (raw materials) by mass:
3.2kg of the pepper extract,
1.7kg of the hydrolyzed keratin is used,
0.16kg of trehalose is added into the sugar,
primary surfactant: 4.2kg of coconut acyl potassium glycinate and 4.2kg of coconut acyl sodium glycinate,
cosurfactant: 2.0kg of cocamide DEA, 2.1kg of cocamidopropyl betaine,
acid-base regulator: 0.18kg of EDTA, 0.18kg of disodium EDTA,
0.7kg of sodium chloride is added,
81.38kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into an aqueous phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the aqueous phase pot, heating the mixture from room temperature to 70 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 40 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 11.38kg of deionized water into the aqueous phase pot, stirring the mixture at constant temperature of 40 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 8
In this example, the bath foam comprises the following components (raw materials) by mass:
3.8kg of the pepper extract,
1.1kg of the hydrolyzed keratin is added,
0.1kg of trehalose is added into the sugar,
primary surfactant: 3.6kg of disodium laureth sulfosuccinate and 3.7kg of potassium laurate,
cosurfactant: 2.2kg of lauramidopropyl hydroxysultaine, 2.2kg of lauryl glucoside,
acid-base regulator: 0.4kg of lactic acid was added,
0.8kg of sodium chloride is added,
82.10kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into a water phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating the mixture from room temperature to 60 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 30 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 12.10kg of deionized water into the water phase pot, stirring the mixture at constant temperature of 30 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 9
In this example, the bath foam comprises the following components (raw materials) by mass:
the Chinese prickly ash extract is 4.4kg,
0.6kg of the hydrolyzed keratin is added,
0.05kg of trehalose is added into the sugar,
primary surfactant: 3.1kg of potassium myristate, 3.1kg of potassium palmitate,
cosurfactant: 2.4kg of lauramidopropyl hydroxysulfobetaine, 2.3kg of lauroamphoacetate,
acid-base regulator: 0.23kg of citric acid, 0.22kg of sodium citrate,
0.9kg of sodium chloride is added,
82.70kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into a water phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating the mixture from room temperature to 80 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 40 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 12.70kg of deionized water into the water phase pot, stirring the mixture at constant temperature of 40 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 10
In this example, the bath foam comprises the following components (raw materials) by mass:
the Chinese prickly ash extract is 5.0kg,
0.1kg of hydrolyzed keratin is added,
0.01kg of trehalose is added into the sugar,
primary surfactant: 2.5kg of potassium stearate, 2.5kg of potassium lauryl phosphate,
cosurfactant: cocamide DEA1.6kg, Cocamide MEA1.7kg, Cocamide methyl MEA1.7kg,
acid-base regulator: 0.25kg of EDTA, 0.25kg of disodium EDTA,
1.0kg of sodium chloride is added,
83.39kg of deionized water;
the preparation method comprises the following steps: firstly, adding 70kg of deionized water into a water phase pot, then adding a main surfactant, an auxiliary surfactant, an acid-base regulator and sodium chloride into the water phase pot, heating the mixture from room temperature to 70 ℃ under normal pressure while stirring, stirring the mixture at constant temperature, cooling the mixture to 35 ℃ after the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride are completely dissolved, then adding the pepper extract, trehalose, hydrolyzed keratin and the rest 13.39kg of deionized water into the water phase pot, stirring the mixture at constant temperature of 35 ℃, and naturally cooling the mixture to room temperature after the pepper extract, the trehalose and the keratin are completely dissolved to obtain the bath foam with the functions of bacteriostasis and itching relieving.
Example 11: anti-inflammatory Effect testing of functional compositions
A, B, C, D, E, F groups were established, which were: group A, a keratin solution with the mass concentration of 2.0 percent prepared by hydrolyzed keratin and deionized water; group B, preparing a 2.0 mass percent pepper extract solution by using pepper extract and deionized water; group C, trehalose solution with mass concentration of 0.2% prepared by trehalose and deionized water; group D, preparing a functional composition solution by using hydrolyzed keratin, pepper extract, trehalose and deionized water, wherein the mass concentration of the hydrolyzed keratin and the pepper extract in the functional composition solution is 2.0 percent, and the mass concentration of the trehalose in the functional composition solution is 0.2 percent; group E, a functional composition solution prepared from hydrolyzed keratin, pepper extract, trehalose and deionized water, wherein the mass concentration of the hydrolyzed keratin and the pepper extract in the functional composition solution is 1.0%, and the mass concentration of the trehalose in the functional composition solution is 0.1%; group F, deionized water.
A, B, C, D, E, F groups were added in equal amounts to the culture solution containing the positive agent carried by the IL-6 (Interleukin-6) kit and the culture solution containing the positive agent carried by the TNF-. alpha.kit, respectively, to form twelve groups of culture solutions, and normal human dermal cells were placed in the twelve groups of culture solutions, respectively, and cultured in a high-sugar medium (HyClone) under saturated humidity, constant temperature of 37 ℃ and 5 v.% carbon dioxide for 24 hours.
After the culture was completed, the expression of IL-6 and TNF-alpha (tumor necrosis factor) were measured by ELISA (enzyme-linked immunosorbent assay) using IL-6 (interleukin-6) and TNF-alpha (tumor necrosis factor) kits, respectively. The test results are shown in table 1 below:
TABLE 1
| Group A | Group B | Group C | Group D | Group E | Group F | |
| IL-6 | 56 | 69 | 94 | 40 | 52 | 100 |
| TNF-α | 52 | 66 | 95 | 39 | 50 | 100 |
Test results show that the functional composition in the groups D and E can obviously inhibit the expression of inflammatory factors IL-6 and TNF-alpha in dermal cells, and has better inhibition effect on skin inflammation.
Example 12: bacteriostatic action test of functional composition
1. Sample preparation: the strains used in the experiment (from the strain center of Beijing biological product authentication): escherichia coli, Staphylococcus aureus, tetanus bacillus, Propionibacterium acnes, Pseudomonas aeruginosa, Candida albicans, and Penicillium were inoculated into a nutrient medium (LB, Nantong Kai Biotech limited), activated at 37 deg.C for 12 hours, prepared into 5mL/L bacterial suspension with sterile water, and placed in a refrigerator at 4 deg.C for use.
Preparing five groups of sample solutions for later use by respectively using a nutrient medium (LB) as a solvent for hydrolyzed keratin, a pepper extract, trehalose and a functional composition (the mass ratio of the hydrolyzed keratin to the pepper extract to the trehalose is 1: 1: 0.1), wherein the mass concentrations of the five groups of sample solutions are respectively hydrolyzed keratin and hydrolyzed keratin is 3.0%; a zanthoxylum bungeanum extract group, 3.0 percent of zanthoxylum bungeanum extract; trehalose group, trehalose 0.3%; functional composition group a, functional composition 3.0%; functional composition group B, functional composition 1.5%; sterile water was used as a control.
2. And (3) bacteriostatic determination: adopting a filter paper diffusion method to make filter paper into 12 small round paper sheets with the diameter of 6mm, then pasting each small round filter paper sheet on a nutrient medium coated with 5ml/L of bacterial suspension respectively (preparing a nutrient culture (LB) base agar plate according to a conventional method and sterilizing by a high-pressure steam sterilization method), taking 10 mul of prepared five sample solutions and sterile water respectively, dripping 5 mul of each sample solution and sterile water on two small round filter paper sheets pasted on the nutrient medium coated with the bacterial suspension respectively, then putting the sample solutions and the sterile water into a 37 ℃ constant-temperature incubator, culturing for 24 hours, observing the growth condition of bacteria, and measuring the diameter of a bacteriostatic ring.
The results are shown in table 2 below (table 2 is the average of two groups of inhibition zone data):
TABLE 2
Note: trehalose is equivalent to sterile water, has almost no bacteriostatic action, and is not shown in Table 2.
Test results show that the functional composition has better bacteriostatic effect.
EXAMPLE 13 rash inhibition assay of functional compositions
1, sample preparation: preparing five groups of sample solutions for later use by using deionized water for preparing hydrolyzed keratin, pepper extract, trehalose and a functional composition (the mass ratio of the hydrolyzed keratin to the pepper extract to the trehalose is 1: 1: 0.1), wherein the mass concentrations of the five groups of sample solutions are respectively hydrolyzed keratin and hydrolyzed keratin 3.0%; a zanthoxylum bungeanum extract group, 3.0 percent of zanthoxylum bungeanum extract; trehalose group, trehalose 0.3%; functional composition group a, functional composition 3.0%; functional composition group B, functional composition 1.5%; deionized water was used as a control.
2. And (3) testing: the rats of the constructed rash test animal model were scrubbed with each of the above sample solutions and 5ml of deionized water 1 time every 4 hours for 5 minutes each time, and the condition of the rat rash was observed.
3. As a result: after 11 rubs with keratin solution, the rash did not develop, and after 20 rubs, it substantially disappeared. After 7 rubs with zanthoxylum bungeanum extract solution, the rash did not develop any more, and after 14 rubs, the rash substantially disappeared. After 5 swabbing with the functional composition a solution, the rash did not develop any more, and after 11 swabbing, the rash substantially disappeared. After 7 scrubs with the functional composition B solution, the rash did not develop any more, and after 13 scrubs, it substantially disappeared. The condition of using trehalose solution for scrubbing is equivalent to that of deionized water, and the effect of inhibiting the rash is not obvious.
Test results show that the functional composition has better effect of inhibiting skin rash.
Claims (5)
1. The bath foam with the functions of bacteriostasis and relieving itching is characterized by comprising a functional composition, wherein the components of the functional composition and the mass fractions of the components in the bath foam are as follows: 0.1 to 5 percent of pepper extract, 0.1 to 5 percent of keratin and 0.01 to 0.5 percent of trehalose.
2. The bath foam with antibacterial and itching relieving functions according to claim 1, characterized by further comprising the following components in percentage by mass:
3. the bath foam with antibacterial and antipruritic effects according to claim 1 or 2, wherein the zanthoxylum bungeanum extract is obtained by distilling and concentrating an extracting solution obtained by circularly extracting or leaching crushed zanthoxylum bungeanum at 40-70 ℃ under normal pressure by using petroleum ether as an extracting agent, and the distilling and concentrating time is determined by that the volume fraction of the petroleum ether is less than 5%;
the keratin is hydrolyzed keratin with molecular weight not more than 200000 daltons.
4. The bath foam with antibacterial and antipruritic effects according to claim 2, wherein the primary surfactant is at least two of ammonium laureth sulfate, sodium lauroyl sarcosinate, potassium cocoyl glycinate, sodium lauroyl glutamate, disodium laureth sulfosuccinate, potassium laurate, potassium myristate, potassium palmitate, potassium stearate, and potassium laureth phosphate;
the auxiliary surfactant is at least two of cocamide DEA, cocamide MEA, cocamide methyl MEA, cocamide propyl betaine, lauramidopropyl hydroxysultaine, ethylene glycol distearate, lauryl glucoside and sodium lauroamphoacetate;
the pH regulator is at least one of citric acid, sodium citrate, EDTA disodium and lactic acid;
the pure water is deionized water or distilled water.
5. The method for preparing the bath foam with bacteriostasis and itching relieving functions of claim 2 or 4, which is characterized in that the components of the bath foam and the mass percent thereof are proportioned, firstly 80-92 percent of the mass of pure water is added into a container with a stirrer, then adding the main surfactant, the auxiliary surfactant, the acid-base regulator and the sodium chloride into a container with a stirrer, heating to 60-80 deg.C under normal pressure while stirring, cooling to 40-30 deg.C when the main surfactant, auxiliary surfactant, acid-base regulator and sodium chloride are completely dissolved, adding fructus Zanthoxyli extract, trehalose, keratin and residual pure water into a container with stirrer, stirring at 40-30 deg.C, and when the pepper extract, the trehalose and the keratin are completely dissolved, naturally cooling to room temperature to obtain the bath foam with the functions of bacteriostasis and relieving itching.
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| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | External preparation for skin characterized by containing saccharide derivative of α,α-trehalose |
| CN102144959A (en) * | 2011-04-19 | 2011-08-10 | 广州好迪集团有限公司 | Bath foam with nourishing and moisturizing functions |
| CN103271850A (en) * | 2013-05-15 | 2013-09-04 | 苏州谷力生物科技有限公司 | Method for preparing bacteriostatic bath foam from pepper extract |
| CN106473940A (en) * | 2016-11-29 | 2017-03-08 | 佛山市芊茹化妆品有限公司 | A kind of multiple-effect bath gel and preparation method thereof |
| CN111265457A (en) * | 2020-03-03 | 2020-06-12 | 包计贤 | Whitening and freckle removing essence composition and preparation method thereof |
| CN113398050A (en) * | 2021-07-20 | 2021-09-17 | 广州极男化妆品有限公司 | Mite-clearing and oil-controlling shower gel |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | External preparation for skin characterized by containing saccharide derivative of α,α-trehalose |
| CN102144959A (en) * | 2011-04-19 | 2011-08-10 | 广州好迪集团有限公司 | Bath foam with nourishing and moisturizing functions |
| CN103271850A (en) * | 2013-05-15 | 2013-09-04 | 苏州谷力生物科技有限公司 | Method for preparing bacteriostatic bath foam from pepper extract |
| CN106473940A (en) * | 2016-11-29 | 2017-03-08 | 佛山市芊茹化妆品有限公司 | A kind of multiple-effect bath gel and preparation method thereof |
| CN111265457A (en) * | 2020-03-03 | 2020-06-12 | 包计贤 | Whitening and freckle removing essence composition and preparation method thereof |
| CN113398050A (en) * | 2021-07-20 | 2021-09-17 | 广州极男化妆品有限公司 | Mite-clearing and oil-controlling shower gel |
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