CN103271850B - Method for preparing bacteriostatic bath foam from pepper extract - Google Patents
Method for preparing bacteriostatic bath foam from pepper extract Download PDFInfo
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- CN103271850B CN103271850B CN201310178652.XA CN201310178652A CN103271850B CN 103271850 B CN103271850 B CN 103271850B CN 201310178652 A CN201310178652 A CN 201310178652A CN 103271850 B CN103271850 B CN 103271850B
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- 239000006260 foam Substances 0.000 title claims abstract description 31
- 230000003385 bacteriostatic effect Effects 0.000 title abstract description 5
- 238000000034 method Methods 0.000 title abstract description 4
- 229940116257 pepper extract Drugs 0.000 title abstract 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 24
- 238000003756 stirring Methods 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 6
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims description 22
- 239000008346 aqueous phase Substances 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 11
- 239000012071 phase Substances 0.000 claims description 9
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 8
- 238000001816 cooling Methods 0.000 abstract description 5
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract description 3
- 241000588724 Escherichia coli Species 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 229960003237 betaine Drugs 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 201000002266 mite infestation Diseases 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 10
- 239000003921 oil Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 230000009514 concussion Effects 0.000 description 3
- 230000001408 fungistatic effect Effects 0.000 description 3
- HIDKSOTTZRMUML-UHFFFAOYSA-M potassium;dodecanoate Chemical compound [K+].CCCCCCCCCCCC([O-])=O HIDKSOTTZRMUML-UHFFFAOYSA-M 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 101100493710 Caenorhabditis elegans bath-40 gene Proteins 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 241001145009 Sophora alopecuroides Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003766 combability Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- -1 fatty acid salt Chemical class 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003348 petrochemical agent Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention relates to a method for preparing bacteriostatic bath foam from a pepper extract. The method comprises the following steps of: dissolving 0.1 % of EDTA-2Na and 1 to 7 % of potassium hydroxide into deionized water and heating to 85 DEG C to obtain a spare water phase; mixing 3 to 10 % of dodecanoic acid, 4 to 15 % of tetradecanoic acid and 1 to 2 % of ethylene glycol distearate and heating to 85 DEG C to obtain a spare oil phase; and adding the oil phase into the water phase, mixing and stirring until the mixture is transparent, adding 10 to 40 % of the pepper extract, 0 to 3 % of alkanolamide and 10 to 35 % of 35 % cocanidoproryl betaine alkali solution, stirring and cooling to below 50 DEG C, adding essence and a preservative, adjusting the pH value to be 6-7, continuously stirring and cooling to 40 DEG C, and outputting to obtain the product. The bacteriostatic bath foam containing the pepper extract has a certain bacteriostatic effect on escherichia coli, staphylococcus aureus and the like, has an effect of preventing eczema, pruritus, mange and the like, and has a certain effect of nourishing skin. The bath foam is simple in formula and can meet the natural, environmentally-friendly and efficiently antibacterial basic requirements of the modern markets.
Description
Technical field
The present invention relates to a kind of antibacterial type bath foam of natural extract, particularly relate to a kind of Folium Zanthoxyli Bungeani extract antibacterial type bath foam.
Background technology
Bath foam is the necessary of people's daily life, as fluid product, be characterized in allocating various functional raw material into, by the Transdermal absorption of effective ingredient, improve the microcirculation situation of skin, strengthen the disease-resistant and repair ability of skin, reach the multipurpose of cleaning skin, nursing skin, promotion skin health.
Constantly perfect along with article of everyday use, bath foam product the liking deeply by consumers in general of plant extract type.The body wash liquid formula of various antibacterial type is applied patent and delivers document.
Application number: Cornu Cervi Pantotrichum, Radix Ginseng Flos Caryophylli, Radix Angelicae Sinensis are extracted extracting solution by the production method main processes of 200910175652.8 sophora alopecuroide bacteriostatic bath foams; Medicinal liquid mixing will be extracted, add Radix Sophorae Flavescentis total alkaloids extractum and become Chinese medicine admixing medical solutions, add deionized water, add hydroxyethyl-cellulose, stir, heat and add sodium lauryl sulphate, cocoanut fatty acid diethanolamide, polyoxyethylenated alcohol sodium sulfate, Pearl Concentrate stirring and dissolving, rise to uniform temperature, stir to be dissolved, after cooling, add acetylbutyrylcellulose, glycerol stirs, be up to the standards and be finished product.
Application number: 201110452222.3 kinds of Chinese medicine antibacterial nourishing bath foams and preparation method thereof, being be raw material by 25 ~ 35 weight portion Radix Sophorae Flavescentiss, 15 ~ 25 weight portion Cortex Phellodendris, 25 ~ 35 weight portion Radix Gentianaes, 15 ~ 25 weight portion Fructus Cnidiis, 15 ~ 25 weight portion Rhizoma Smilacis Glabraes, take water as the Chinese medicine extraction liquid that extracting solution extracts the d=1.5 ~ 1.8g/ml obtained.Chinese medicine antibacterial nourishing bath foam of the present invention has certain fungistatic effect to escherichia coli, staphylococcus aureus, Candida albicans.
By Wu Jianguo, Tan Qun etc. study the development of the Folium Zanthoxyli Bungeani bath foam delivered, be published in Speciality Petrochemicals progress the 13rd volume the 8th phase literature periodical, mainly have studied the Pericarpium Zanthoxyli bath foam obtained for raw material with Folium Zanthoxyli Bungeani extract, preparation process is for will add people's AESA successively under deionized water heated and stirred, lauryl alcohol ammonium sulfate, Oleum Cocois diethanol phthalein amine, lauryl phosphoric acid vinegar potassium salt, alkyl glucose former times, cocos nucifera oil phthalein amine CAB and E D TA disodium, cooling after dissolving completely, add people's Folium Zanthoxyli Bungeani extract, regulate p H to 6-7, stirring is cooled to less than 45 DEG C, add people's antiseptic and essence, continue to stir cooling, obtained product.
Folium Zanthoxyli Bungeani is the by-product in Pericarpium Zanthoxyli plantation, development Folium Zanthoxyli Bungeani bath foam can develop a large amount of discarded Pericarpium Zanthoxyli branch and leaf, the considerable economic benefit for agricultural economy band.The chemical composition of Folium Zanthoxyli Bungeani is similar to peel, extract mainly contains volatile oil, alkaloid, flavone etc., experiment proves that Folium Zanthoxyli Bungeani extract is to staphylococcus aureus, bacillus subtilis and escherichia coli all have fungistatic effect, especially to staphylococcus aureus and bacillus subtilis successful, and the application of exploitation Folium Zanthoxyli Bungeani in bath article, both the trend of cosmetics to natural chemotherapy effectization future development had been complied with, consumer can be met again to skin care, clean, the needs of nursing.
Summary of the invention
The invention provides the antibacterial bath foam preparation method of a kind of Fructus Zanthoxyli extract, not only production cost is low, fungistatic effect is obvious, and develop a large amount of discarded Pericarpium Zanthoxyli branch and leaf and can promote agro based economic development.
The antibacterial bath foam preparation method of a kind of Fructus Zanthoxyli extract, being dissolved in deionized water by EDTA-2Na 0.1%, potassium hydroxide 1% ~ 7%, being heated to 85 DEG C, is aqueous phase; Dodecoic acid 3% ~ 10%, tetradecylic acid 4% ~ 15%, ethylene glycol distearate 1% ~ 2% are mixed, being heated to 85 DEG C, is oil phase; Oil phase is added in aqueous phase, mix and blend, until transparent, add Fructus Zanthoxyli extract 10 ~ 40%, alkanolamide 0 ~ 3%, 35% cocamido propyl betaine solution 10% ~ 35%, stir and be cooled to less than 50 DEG C, add appropriate amount of essence and antiseptic, regulate p H to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.
In dodecoic acid, tetradecylic acid and potassium hydroxide and generate potassium dodecanoate, tetradecylic acid potassium surfactant, it is the foaming agent of bath foam.Increase the frothing capacity that fatty acid salt content can significantly improve bath foam, the frothing capacity of potassium dodecanoate is slightly better than tetradecylic acid potassium, but zest is slightly larger than tetradecylic acid potassium, and the cost ratio dodecoic acid height of tetradecylic acid is more, so the consumption of the two should be determined by product price.Potassium hydroxide is as nertralizer, and its consumption is advisable to control product about pH=7.Potassium dodecanoate, tetradecylic acid potassium detergency ability are better, and are very easy to rinse, and overcome the shortcoming that bath foam has soapy feeling.
35% cocamido propyl betaine solution is betaine type amphoteric surfac-tant, there is washing and conditioning effect, zest is low, add the zest that can reduce anion surfactant in formula, certain thickening effect is had to anion surfactant, and there is good stable foam effect, its consumption should be determined according to bath foam type and effect.Alkanolamide mainly plays thickening and steady bubble effect in formula, and its consumption is advisable with about 3%.
The best in quality formula proportion that the present invention selects is: dodecoic acid 8.5%; Tetradecylic acid 4.5%; Potassium hydroxide 3.8%; 35% cocamido propyl betaine solution 30%; Alkanolamide 3%; Ethylene glycol distearate 1.5%; EDTA-2Na 0. 1%; Fructus Zanthoxyli extract 40%; Antiseptic, essence each 0.1%; Deionized water is appropriate.
The preparation of Folium Zanthoxyli Bungeani extract: pericarpium zanthoxyli bungeani leaf is pulverized, the methanol of concentration 50% is added as extractant by solid-liquid ratio 1g: 25ml, at room temperature shake, separation of supernatant, and obtaining extractum by after supernatant concentration drying, be scattered in by extractum in purified water, solid-liquid ratio is 1g: 40ml, then add normal hexane concussion extraction, collect aqueous phase extract; Again aqueous phase raffinate is added chloroform, concussion extraction, collects aqueous phase raffinate; Then aqueous phase raffinate is added ethyl acetate in right amount, concussion extraction, concentrate drying obtains extract.
Folium Zanthoxyli Bungeani extract and surfactant compatibility good, maximum addition can reach 40%, does not substantially affect physical and chemical index and the performance of bath foam product.Folium Zanthoxyli Bungeani is got thing and is had obvious antipruritic effect for bath foam, and to treatment erythra, also certain effect Folium Zanthoxyli Bungeani extract is had to be all-natural product, have no side effect, use safety, Folium Zanthoxyli Bungeani extract is used for bath foam, complies with the trend of the market that cosmetics develop to naturalization and curative effectization.Also make full use of discarded Folium Zanthoxyli Bungeani is that agricultural opens a new developing direction simultaneously.
Involved in the present invention to the unit of component percentages be mass percent (wt%)
The kind of the antiseptic of described essence and consumption can carry out selecting and adding according to pharmaceutical field common practise.
EDTA-2Na 0. 1%, potassium hydroxide 3.8% are dissolved in deionized water by embodiment 1, are heated to 85 DEG C, are aqueous phase; Dodecoic acid 8.5%, tetradecylic acid 4.5%, ethylene glycol distearate 1.5% being mixed, be heated to 85 DEG C, is oil phase; Oil phase is added in aqueous phase, mix and blend, until transparent, add Fructus Zanthoxyli extract 40%, alkanolamide 3%, 35% cocamido propyl betaine solution 30%, stir and be cooled to less than 50 DEG C, add appropriate amount of essence and antiseptic, regulate p H to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.Bacteriostasis rate reaches 99%
EDTA-2Na 0. 1%, potassium hydroxide 3.8% are dissolved in deionized water by embodiment 2, are heated to 85 DEG C, are aqueous phase; Dodecoic acid 8.5%, tetradecylic acid 4.5%, ethylene glycol distearate 1.5% being mixed, be heated to 85 DEG C, is oil phase; Oil phase is added in aqueous phase, mix and blend, until transparent, add Fructus Zanthoxyli extract 10%, alkanolamide 3%, 35% cocamido propyl betaine solution 30%, stir and be cooled to less than 50 DEG C, add appropriate amount of essence and antiseptic, regulate p H to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.Bacteriostasis rate reaches 89%.
Embodiment 1 proof test
1. malicious combability measurements
Select the healthy mice of body weight 20-25g, male and female half and half, are divided into and give the Pericarpium Zanthoxyli bath foam liquid that accumulated dose is 20g/kg for 2 times ~ 3 times in 24 h, adopt administration by gavage, be inserted into white mouse gastric inject with syringe.Continuous Observation seven days, none is dead for white mice, and has no abnormal symptom.Result of the test shows, the LD50 of stock solution to male and female white mice is all greater than 20g/kg, the nontoxic level in true border.
2. recruitment evaluation
Choose 40 volunteers to try out Folium Zanthoxyli Bungeani bath foam, trial period 30 d, use Folium Zanthoxyli Bungeani bath foam 2-3 time weekly, collect the evaluation that experimenter suppresses de-sludging performance, skin pruritus, bathes rear pleasant sense, dispels the projects such as erythra,
Result on trial shows, Folium Zanthoxyli Bungeani bath foam detergency is strong, foaming abundancy, and antipruritic effect is obvious, and after bathing, dermal sensation is pleasant, and also has certain effect to treatment erythra.
Pericarpium Zanthoxyli bath foam result on trial
| Test event | Tested number | Efficiently individual quantity | Effective percentage |
| De-sludging performance | 40 | 40 | 100.0% |
| Skin pruritus suppresses | 40 | 28 | 93.3% |
| Pleasant sense after bath | 40 | 39 | 97.5% |
| Dispel erythra | 40 | 36 | 90.0% |
Claims (1)
1. Folium Zanthoxyli Bungeani extract is a preparation method for the antibacterial bath foam of raw material, it is characterized in that step is as follows:
1) EDTA-2Na 0. 1wt%, potassium hydroxide 3.8wt% are dissolved in deionized water, are heated to 85 DEG C, obtain aqueous phase for subsequent use;
2) dodecoic acid 8.5wt%, tetradecylic acid 4.5wt%, ethylene glycol distearate 1.5wt% are mixed, be heated to 85 DEG C, obtain oil phase for subsequent use;
3) oil phase is added in aqueous phase, mix and blend, until transparent, add Folium Zanthoxyli Bungeani extract 40wt%, alkanolamide 3wt%, 35% cocamido propyl betaine solution 30wt%, stir and be cooled to less than 50 DEG C, add essence and antiseptic, regulate pH to 6-7, continue stirring again and be cooled to 40 DEG C, discharging, be product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310178652.XA CN103271850B (en) | 2013-05-15 | 2013-05-15 | Method for preparing bacteriostatic bath foam from pepper extract |
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| CN201310178652.XA CN103271850B (en) | 2013-05-15 | 2013-05-15 | Method for preparing bacteriostatic bath foam from pepper extract |
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| CN103271850A CN103271850A (en) | 2013-09-04 |
| CN103271850B true CN103271850B (en) | 2015-06-03 |
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| CN109259018A (en) * | 2018-10-24 | 2019-01-25 | 中国科学院兰州化学物理研究所 | The Preparation method and use of extractive of general flavone with health care function in a kind of bunge pricklyash leaf |
| CN113797135B (en) * | 2021-10-25 | 2023-06-23 | 广州好迪集团有限公司 | Bath foam with antibacterial and antipruritic functions and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559380A (en) * | 2004-03-08 | 2005-01-05 | 浙江大学 | massage bath salt |
| CN1633985A (en) * | 2004-11-01 | 2005-07-06 | 江苏隆力奇生物科技股份有限公司 | Easy Rinse Moisturizing Body Wash |
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2013
- 2013-05-15 CN CN201310178652.XA patent/CN103271850B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559380A (en) * | 2004-03-08 | 2005-01-05 | 浙江大学 | massage bath salt |
| CN1633985A (en) * | 2004-11-01 | 2005-07-06 | 江苏隆力奇生物科技股份有限公司 | Easy Rinse Moisturizing Body Wash |
Non-Patent Citations (1)
| Title |
|---|
| 花椒叶沐浴液的研制;巫建国等;《精细石油化工进展》;20120831;第13卷(第8期);第36-38页 * |
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| CN103271850A (en) | 2013-09-04 |
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