CN102755281A - Cosmetic containing microbial modulator - Google Patents
Cosmetic containing microbial modulator Download PDFInfo
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- CN102755281A CN102755281A CN2012102421608A CN201210242160A CN102755281A CN 102755281 A CN102755281 A CN 102755281A CN 2012102421608 A CN2012102421608 A CN 2012102421608A CN 201210242160 A CN201210242160 A CN 201210242160A CN 102755281 A CN102755281 A CN 102755281A
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- cosmetics
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- bacillus bifidus
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 31
- 230000000813 microbial effect Effects 0.000 title abstract 2
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 20
- 244000005700 microbiome Species 0.000 claims description 16
- 241000894006 Bacteria Species 0.000 claims description 15
- 239000006071 cream Substances 0.000 claims description 9
- 230000000474 nursing effect Effects 0.000 claims description 8
- 235000013336 milk Nutrition 0.000 claims description 7
- 239000008267 milk Substances 0.000 claims description 7
- 210000004080 milk Anatomy 0.000 claims description 7
- 230000003796 beauty Effects 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 230000001580 bacterial effect Effects 0.000 claims description 4
- 241001446187 Kermes Species 0.000 claims description 3
- 239000008294 cold cream Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- CXORMDKZEUMQHX-UHFFFAOYSA-N kermesic acid Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C CXORMDKZEUMQHX-UHFFFAOYSA-N 0.000 claims description 3
- 235000012459 muffins Nutrition 0.000 claims description 3
- 239000002304 perfume Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- 230000036559 skin health Effects 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 241000186000 Bifidobacterium Species 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 238000003756 stirring Methods 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 230000002421 anti-septic effect Effects 0.000 description 6
- 238000000855 fermentation Methods 0.000 description 6
- 230000004151 fermentation Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 235000021355 Stearic acid Nutrition 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000010985 leather Substances 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 206010040882 skin lesion Diseases 0.000 description 4
- 231100000444 skin lesion Toxicity 0.000 description 4
- 239000008117 stearic acid Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 241000218628 Ginkgo Species 0.000 description 3
- 235000011201 Ginkgo Nutrition 0.000 description 3
- 235000008100 Ginkgo biloba Nutrition 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000000498 cooling water Substances 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 150000002338 glycosides Chemical class 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000006041 probiotic Substances 0.000 description 3
- 235000018291 probiotics Nutrition 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000000529 probiotic effect Effects 0.000 description 2
- 238000011218 seed culture Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 241000589220 Acetobacter Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 235000003935 Hippophae Nutrition 0.000 description 1
- 241000229143 Hippophae Species 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- 241000223254 Rhodotorula mucilaginosa Species 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to a cosmetic containing a microbial modulator. The cosmetic comprises 0.5-1wt% of bifidobacterium; the bifidobacterium is adopted as a microecological modulator of the cosmetic, and the produced microecological cosmetic can be used for prompting the metabolism of the skin to achieve the effects of protecting skin and beautifying; and the cosmetic can be industrially produced by virtue of the technique and is beneficial to skin health of people.
Description
Technical field
The present invention relates to contain the cosmetics of microorganism regulator, relate in particular to a kind of cosmetics that contain bacillus bifidus.
Background technology
Microecologic regulator is under the microecology theoretical direction, adjusts little ecological disturbance, keeps microecological balance, improves the skin health level or promotes the probiotic bacteria of skin health state and the goods of metabolite and growth helping matter thereof.Microecology is a new branch of science of setting up over 20 years He grow up, and it is " the life sciences branch of research normal microflora and its host's mutual relation ".Microecology has been illustrated the substantial connection between human existence and development and the microorganism of its coexistence, and it has pointed out people's all one's life all the time with of a great variety, and the microorganism of enormous amount is accompanied together.Data shows that an adult TCS is 1014, and normal flora is that quantity is 1013 in the body, so the people is not an isolated people, and the people is the homobium of himself and microorganism.Discover that the normal strain that the human body skin surface exists can reach over one hundred kind; Topmost staphylococcus epidermidis, propionibacterium, yeast, diphtheroid, excellent bacillus, lactobacillus, bacillus bifidus or the like of comprising; The dynamic equilibrium of these floras is determiners of maintenance human body skin health and eubolism, and this point is the basic conception of skin microecology.Inherent micro-ecological bacterial crowd and skin are under a kind of dynamic equilibrium, can think the skin of health.Make skin keep microecological balance just to be able to bacterium and mend bacterium; Control bacterium with bacterium because skin since self, environment, medicine, their microecological balance is lacked of proper care through regular meeting; Must make it to restore balance from extraneous probiotic supplemented or probiotics factor at any time, improve health.
Chinese patent 97112152.4 discloses a kind of cosmetics that contain the microorganism regulator, it is characterized in that it is 1% ~ 10% youth's Bick candida mycoderma and/or Rhodotorula rubra HMC or its metabolite that said cosmetics contain percentage by weight.But saccharomycetic shortcoming is: yeast is the transition bacterium, it can not field planting in skin, so can not participate in the Human Physiology circulation, have only continual supply to play effect to skin, be further improved.
Summary of the invention
The present invention is directed to above-mentioned deficiency, a kind of physiology circulation that can participate in human body is provided, can fundamentally play skin-protecting face nursing, the cosmetics that contain the microorganism regulator of the effect of adjustment skin microecological balance.
The present invention is for solving the problems of the technologies described above; Following technical scheme is provided: a kind of cosmetics that contain the microorganism regulator; It is characterized in that in described cosmetics, containing percentage by weight and be 0.5% ~ 1% bacillus bifidus, described bacillus bifidus is a hebephrenictype bacillus bifidus DM8504 bacterial strain.
As of the present invention preferred, described bacillus bifidus is dead bacterium or viable bacteria.
As of the present invention preferred, described cosmetics are cleaning type, nursing type, beauty treatment/modification class.
As of the present invention preferred, the cleaning class is cleansing milk, facial film, cleansing cream.
As of the present invention preferred, the nursing class is cold cream frost, emulsion, astringent.
As of the present invention preferred, beauty treatment/modification class is muffin, kermes, eye shadow, perfume.
The production technology of microecologic regulator bacillus bifidus of the present invention is known, and production technology may further comprise the steps:
Slant medium: adopt the BS slant medium, PH7.2-7.4, the inclined-plane is put in sterilization in 121 ℃, 30 minutes after the packing, and empty the cultivation after 2 days preserved in refrigerator.
Liquid seed culture medium: adopt the BS fluid medium.PH7.2-7.4 gets 500ml and is sub-packed in the infusion bottle, and sterilization in 121 ℃, 30 minutes is for use.
Get DM8504 lyophilizing pipe, with the lyophilizing pipe sterilize, sever, add activator, picking bacterium liquid is streak culture, isolates colonies typical and passes slant culture, behind assay approval, use as female inclined-plane.
Be inoculated in sub-inclined-plane by female inclined-plane, sub-inclined-plane under anaerobic 37 ℃ cultivated 48 hours.
Being inoculated in behind the seed bottle 37 ℃ by sub-inclined-plane cultivated 48 hours.Inspection should meet the standard type of hebephrenictype bacillus bifidus under the sub-flat inclined mirror after the cultivation: growth promoter is good; Seed culture fluid should be sepia after cultivating, and a small amount of canescence solids precipitation is arranged at the bottom, and seed liquor PH should be more than 4.5; Mirror is observed down and should be G-, is shaft-like uneven thalline.
Seed liquor is concentrated in the bottle,suction, be inoculated in the fermentation tank with the pressure reduction vaccination ways.
Before last jar total air filter, branch air filter, fermentation tank and each pipeline are carried out disinfection, the time is 45 minutes, and pressure is 0.2MPa.
Begin fermentation culture after the inoculation, condition of culture is 37 ± 1 ℃ of temperature, and pressure 0.02-0.04MPa stirred time 22-26 hour 5 minutes/3 hours.Record fermentation temperature, pressure, mixing time and situation such as number of times, PH, incubation time and fermentation liquid metabolism pollution.
Put a jar time with parameter determining such as fermentation liquid pollution condition, time, PH, microscopies.Generally reduce to 4.5 and can put jar when following cultivating after 22 hours PH.
Put a jar culture fluid be compressed air be pressed into flexible centrifuge carry out centrifugal, with valve adjustment centrifugal liquid flow, generally with in the centrifugal liquid not mycetome be advisable.Concentrator bowl is taken out in centrifugal back, sends into the dry thalline that takes out.
Scrape the bacterium mud of getting in the concentrator bowl, weighing.Get 5% sodium glutamate and 1 part of 5% defatted milk powder that 1 part in bacterium mud adds 1 to 1.5 part, fully mix, put not in the stainless steel disc.Material to be dried is put into freezer dryer carry out drying.
After lyophilizing finished, freeze drying box still was in vacuum state, must feed aseptic dry air or nitrogen before the product outlet and can open valve taking-up product, preserved with lower seal for 4 ℃.The product water content should be controlled at below 3%, promptly produces hebephrenictype bacillus bifidus DM8504.
Beneficial effect of the present invention: the present invention adopts the microecologic regulator of bacillus bifidus as cosmetics; Little skin-care ecological article of producing can promote the metabolism of skin; Reach the effect of skin-protecting face nursing, and this technology can organize the cosmetics suitability for industrialized production, benefit the health of human body skin.
The specific embodiment
A kind of cosmetics that contain the microorganism regulator; It is characterized in that in described cosmetics, containing percentage by weight and be 0.5% ~ 1% bacillus bifidus, described bacillus bifidus is a hebephrenictype bacillus bifidus DM8504 bacterial strain, and described bacillus bifidus is dead bacterium or viable bacteria; Described cosmetics are cleaning class, nursing class, beauty treatment/modification class; The cleaning class is cleansing milk, facial film, cleansing cream, and the nursing class is cold cream frost, emulsion, astringent, and beauty treatment/modification class is muffin, kermes, eye shadow, perfume.
Embodiment 1: contain the cleansing milk of microecologic regulator, (prescription) wherein each composition weight is percentage ratio: HANSHENGJIAO 0.4%, and AES 7%, Semen Ginkgo glycoside 1%; Microecologic regulator 1%, 1-3 butanediol 2%, 200 7%; Stearic acid 4%, pearly-lustre thickening agent 620 1.6%, C-30 5.12%; Essence 0.2%, antiseptic 901 1.5%, deionized water 72% (3% evaporation capacity is arranged).
Production technology: weighing deionized water 72% adds in the retort, is heated to 80 ℃-85 ℃, adds Semen Ginkgo glycoside (production of Jilin pharmaceutical factory) and microecologic regulator of the present invention; Add 1-3 butanediol (production of Shanghai Henkel Corp.); After treating off-bottom, add thickening agent HANSHENGJIAO (production of Shanghai Henkel Corp.), treat to add after the off-bottom AES (production of Shanghai Henkel) and add 200 and stearic acid simultaneously; Whole process stirs and continues, and keeps temperature more than 70 ℃; C-30 is slowly joined retort after with water dissolution, and temperature maintenance stirs at 70 ℃ and continues 10 minutes, opens cooling water and slowly lowers the temperature; Treat that temperature reduces to 50 ℃ and add pearly-lustre thickening agents 620; Add antiseptic 901 simultaneously, essence treats to process when temperature is reduced to 40 ℃ cleansing milk of the present invention.
The milk of washing one's face: observe 1500 many cases altogether, 460 examples are wherein filled in the observation form.
Experimental period is 25 days, criterion of therapeutical effect: skin reaches salubrious, flexible, preserve moisture to effectively.
Embodiment 2: contain the cream kind of microecologic regulator, wherein each composition weight is percentage ratio, oil phase: stearic acid 5%, hexadeca-octadecyl alcohol 8%; Oleum Hippophae 3%, Adeps Bovis seu Bubali resin 4%, lanoline 8%, dimethicone 5%; Glycerol 3%, 68 1%, OP2%, white oil 1%; Water: Semen Ginkgo glycoside 1%, the ginsenoside 1%; Microecologic regulator 1%; Other: essence 0.2%, antiseptic 901 3%, deionized water 56.8% (3% is used for evaporation).
Production technology: with the accurate weighing of oil phase raw material, drop in the oil phase jar, heat while stirring to 85 ℃-90 ℃ constant temperature 5-10 minutes; With the accurate weighing of water raw material, drop in the water jar, start and be heated with stirring to 90 ℃-95 ℃, constant temperature 5-10 minutes; Be preheated to 45 ℃-50 ℃ to the vacuum emulsification jar, be evacuated to 0.05-0.06Mpa; The ready oil phase raw material of elder generation's suction, the ready water raw material of suction is opened quick homogenizer and blender simultaneously again; Homogenizing 8 minutes, stir speed (S.S.) are 80rpm, stir after 10 minutes; Open cooling water and slowly be cooled to 75 ℃, opened the homogenizer homogenizing again 5 minutes, stir and carry out always.When temperature is reduced to 60 ℃, add antiseptic, when reducing to 50 ℃, add essence, when temperature is reduced to 40 ℃, stop to stir, process the cream kind cosmetics that the present invention obtains.
Cream kind:
With the skin whitener is example:
Observe 1000 many cases altogether, 360 examples are wherein filled in the observation form.
Be equally divided into two groups, smear the skin whitener that contains microecologic regulator (bacillus bifidus) for one group; Another group is smeared traditional skin whitener.The time of smearing is three months.
Criterion of therapeutical effect: recovery from illness: skin lesion all disappears, and it is normal that color of the leather recovers.
Produce effects: the skin lesion area dwindles more than 70%, and color of the leather obviously disappears.
Effectively: the skin lesion area dwindles more than 50%, the color of the leather minor regression.
Invalid: the skin lesion area dwindles below 30%, color of the leather minor regression or do not have improvement.
Therapeutic effect contrast after three months, like following table:
Embodiment 3: the mass percent that contains the foundation cream apoplexy due to endogenous wind essence of microecologic regulator is oil phase: hexadeca-octadecyl alcohol 8%, and triglyceride 5%, stearic acid 8%, dimethicone 3%, white oil 1.5%, lanoline 4%, OT 2%; Water: microecologic regulator 0.5%, powder base 1%; Other: antiseptic 3%, essence 0.2%, deionized water 66.8% (3% is used for evaporation).
Production technology: with the accurate weighing of oil phase raw material, drop in the oil phase jar, heat while stirring to 80 ℃-85 ℃ constant temperature 10 minutes; With the accurate weighing of water raw material, drop in the water jar, be heated to 85 ℃-90 ℃, constant temperature 10 minutes; Be preheated to 45 ℃ to the vacuum emulsification jar, be evacuated to-0.06Mpa; The ready oil phase raw material of elder generation's suction is opened and is stirred 60rpm, homogenizing 2000rpm, the ready water raw material of suction simultaneously, and stir speed (S.S.) is 80rpm, homogenizing 3000rpm, homogenizing stirred and carry out always after 10 minutes; After homogenizing stops, open cooling water and begin to cool down, mixing speed is slowly reduced to 60rpm, continue to be cooled to 50 ℃ after, add essence, antiseptic, stir and reduce to 40rpm, when temperature is cooled to 40 ℃, stop to stir, process the foundation cream class cosmetics that the present invention obtains.
Foundation cream class: with the sun-proof example that is isolated into: observe 500 many cases, 180 examples are wherein filled in the observation form.
Be equally divided into two groups, one group is used the sun-proof isolation that contains microecologic regulator (bacillus bifidus); Another group is used traditional sun-proof isolation.Experimental period is August.
Criterion of therapeutical effect: skin does not have influence for effective:
Claims (7)
1. cosmetics that contain the microorganism regulator is characterized in that in described cosmetics, containing percentage by weight and are 0.5% ~ 1% bacillus bifidus.
2. a kind of cosmetics that contain the microorganism regulator according to claim 1 is characterized in that described bacillus bifidus is a hebephrenictype bacillus bifidus DM8504 bacterial strain.
3. a kind of cosmetics that contain the microorganism regulator according to claim 2 is characterized in that described bacillus bifidus is dead bacterium or viable bacteria.
4. a kind of cosmetics that contain the microorganism regulator according to claim 1 is characterized in that described cosmetics are cleaning class, nursing class, beauty treatment/modification class.
5. a kind of cosmetics that contain the microorganism regulator according to claim 4 is characterized in that the cleaning class is cleansing milk, facial film, cleansing cream.
6. a kind of cosmetics that contain the microorganism regulator according to claim 4 is characterized in that the nursing class is cold cream frost, emulsion, astringent.
7. a kind of cosmetics that contain the microorganism regulator according to claim 4 is characterized in that beauty treatment/modification class is muffin, kermes, eye shadow, perfume.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102421608A CN102755281A (en) | 2012-07-13 | 2012-07-13 | Cosmetic containing microbial modulator |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102421608A CN102755281A (en) | 2012-07-13 | 2012-07-13 | Cosmetic containing microbial modulator |
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| CN102755281A true CN102755281A (en) | 2012-10-31 |
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Cited By (4)
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| CN103251547A (en) * | 2013-05-02 | 2013-08-21 | 华南理工大学 | Activated probiotic skin cream and preparation method thereof |
| EP3052077A4 (en) * | 2013-10-03 | 2017-04-26 | ELC Management LLC | Topical preparations comprising grape seed, folic acid, biotin, bifidobacterium longum and echinacea purpurea |
| CN110478309A (en) * | 2019-09-27 | 2019-11-22 | 无锡宾西利悦科技有限公司 | A kind of composition of the shining face of tender skin |
| CN110876708A (en) * | 2019-11-25 | 2020-03-13 | 无锡宾西利悦科技有限公司 | Composition for repairing damaged cells |
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| CN103251547A (en) * | 2013-05-02 | 2013-08-21 | 华南理工大学 | Activated probiotic skin cream and preparation method thereof |
| EP3052077A4 (en) * | 2013-10-03 | 2017-04-26 | ELC Management LLC | Topical preparations comprising grape seed, folic acid, biotin, bifidobacterium longum and echinacea purpurea |
| CN110478309A (en) * | 2019-09-27 | 2019-11-22 | 无锡宾西利悦科技有限公司 | A kind of composition of the shining face of tender skin |
| CN110876708A (en) * | 2019-11-25 | 2020-03-13 | 无锡宾西利悦科技有限公司 | Composition for repairing damaged cells |
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