CN102716045B - Shampoo composition containing double anti-dandruff agents - Google Patents

Abstract

The invention relates to a shampoo composition containing double anti-dandruff agents. The shampoo comprises (A) anionic surfactants accounting for 5.0 percent to 30 percent of the weight of the composition, amphoteric surfactants accounting for 1.5 percent to 8.0 percent of the weight of the composition, thickening agents accounting for 0.5 percent to 5.0 percent of the weight of the composition and regulating agents accounting for 2.0 percent to 10 percent of the weight of the composition; (B) anti-dandruff sterilization agents accounting for 0.01 percent to 3.0 percent of the weight of the composition, wherein the anti-dandruff sterilization agents are compositions of PTO (piroctone olamine) and ZPT (zinc pyrithione) at a proportion being 1:100-2:3; (C) additives with anti-dandruff and synergistic effects accounting for 0.01 percent to 1.0 percent of the weight of the composition, and at least one kind of materials selected from vitamin E, provitamin B5 and vitamin B12; (D) cationic protein hydrolysate accounting for 0.05 percent to 1 percent of the weight of the composition; and (E) the balance water.

Description

A shampoo composition containing double anti-dandruff agents

technical field

The invention belongs to the field of daily chemicals, and in particular relates to a nourishing anti-dandruff shampoo composition containing double anti-dandruff components.

Background technique

Dandruff is a product of the metabolism of epidermal cells on the human head. The normal metabolic process of hair is that epidermal cells gradually proliferate and mature from the base layer to the outer layer, forming the cuticle and falling off. Due to excessive stress, mental stress, fatigue, inferior shampoo, drug use, air pollution, and the action of microorganisms and bacteria, the metabolism of scalp cells is abnormal in modern people, and the cells become larger, thicker, and fall off into dandruff. life has brought great inconvenience. It is generally believed that the incomplete keratinization of scalp surface cells and the parasitism of pityriasis ovale are the main reasons for the increase of dandruff, and the generation of dandruff creates favorable conditions for the growth and reproduction of microorganisms, which in turn stimulates the scalp and causes itching , Accelerate the abnormal reproduction of epidermal cells. Therefore, inhibiting the rate of cell keratinization, thereby reducing the rate of epidermal metabolism and sterilization are the main ways to prevent and treat dandruff.

The current anti-dandruff shampoo is mainly composed of a single anti-dandruff bactericide such as zinc pyrithione (ZPT) plus a surfactant. The anti-dandruff product with zinc pyrithione (ZPT) as the main active ingredient works by (1) killing Pityriasis ovale and (2) effectively removing excess sebum from the scalp. Zinc pyrithione (ZPT) has a certain anti-dandruff effect and is currently the mainstream anti-dandruff agent. However, there are still many deficiencies in the technology and application of the hair shampoo products with ZPT combined with surfactants, such as, the scalp and hair are dry after washing, and have the disadvantages of strong hair and scalp degreasing and poor rinse conditioning. At the same time, due to the strong degreasing, increase It increases the irritation of the scalp and the metabolism speed of the hair epidermis, which in turn triggers the acceleration of keratinization of the scalp epithelial cells (increases the amount of keratinocytes exfoliated from the scalp surface), thus making the anti-dandruff effect unsustainable and constantly producing dandruff. crumbs. This is the main reason why adopting a single anti-dandruff product cannot satisfy consumer demand at present.

Contents of the invention

The object of the present invention is to provide a shampoo composition, which has the characteristics of good anti-dandruff effect and long duration of anti-dandruff and antipruritic.

The composition of the present invention comprises: characterized in that it comprises:

(A) Anionic surfactants accounting for 5.0% to 30% by weight of the composition, amphoteric surfactants accounting for 1.5% to 8.0% by weight of the composition, and amphoteric surfactants accounting for 0.5% to 5.0% by weight of the composition, suitable for use in shampoo compositions Thickeners and conditioners from 2.0% to 10% by weight of the composition;

(B) An anti-dandruff agent accounting for 0.01 to 3% by weight of the composition; wherein the anti-dandruff agent is a composition of pyridine ketone ethanolamine salt and pyrithione salt, and the weight ratio of the two is 1:100 to 2:3 ;

(C) an anti-dandruff synergistic additive accounting for 0.01% to 1.0% by weight of the composition, and the anti-dandruff synergistic additive is selected from at least one of vitamin E, provitamin B ₅ , and vitamin B ₁₂ ;

(D) dodecyl-octadecyl dimethyl hydroxypropyl hydrolyzed collagen ammonium chloride accounting for 0.05% to 1.0% by weight of the composition;

and (E) balance is water.

The shampoo composition of the present invention, wherein the anionic surfactant is selected from lauryl ammonium sulfate or lauryl polyoxyethylene ether ammonium sulfate, and the amphoteric surfactant is cocamidopropyl betaine; the thickener is ortho Phthalic acid amide; conditioning agent is selected from at least one of cationic cellulose polymer, cationic guar gum, emulsified silicone oil;

The shampoo composition of the present invention, wherein the anti-dandruff agent is a composition of pyrithionethanolamine and zinc pyrithione salt, and the weight ratio of the two is 1:10 to 1:1.5;

The shampoo composition of the present invention, wherein the pyridone ethanolamine is a compound of 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone and monoethanolamine , such as structural formula (I), wherein the molar ratio of 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone to monoethanolamine is 1 :1:

In the shampoo composition of the present invention, the zinc pyrithione particles have an average particle size of at most 5 µm.

The shampoo composition of the present invention, wherein the cationic hydrolyzed protein content accounts for 0.2% to 0.5% of the weight of the composition

Its preferred components and content of the shampoo composition of the present invention are:

(A) Ammonium lauryl sulfate and ammonium lauryl polyoxyethylene ether sulfate, which are suitable for use in shampoo compositions, accounting for 10% to 25% of the weight of the composition, accounting for 2.0% to 6.0% of the weight of the composition. Cocamidopropyl Betaine, phthalic acid amide accounting for 1.0% to 4.0% by weight of the composition and emulsified silicone oil accounting for 3.0% to 8.0% by weight of the composition;

(B) An anti-dandruff bactericide accounting for 0.05% to 2.0% by weight of the composition, wherein the anti-dandruff bactericide is a composition of pyridine ketone ethanolamine and pyrithione zinc, and the weight ratio of the two is 1:10 to 1 : 1.5;

(C) 0.05% to 0.5% by weight of the composition of an anti-dandruff synergistic additive selected from vitamin B12;

(D) dodecyl-octadecyl dimethyl hydroxypropyl hydrolyzed collagen ammonium chloride accounting for 0.1% to 0.5% by weight of the composition;

and (E) the balance is water.

The selection and function of the components of the present invention will be described in detail below.

A. Basic components

The essential components of the nourishing anti-dandruff shampoo composition of the present invention include anionic surfactants, amphoteric surfactants, thickeners and conditioning agents, each of which is described in detail hereinafter.

The surfactant in the shampoo uses its penetrating, emulsifying and dispersing functions to remove the dirt from the hair and scalp to cleanse. The nourishing anti-dandruff shampoo composition of the present invention comprises 5.0% to 30% by weight of the composition, preferably 10% to 25%, of anionic surfactants suitable for use on hair or skin, preferably ammonium lauryl sulfate, polylauryl The composition of ammonium oxyethylene ether sulfate, wherein the addition number of ethylene oxide (EO) in the composition of ammonium lauryl alcohol polyoxyethylene ether sulfate is 2 to 4, preferably the addition number of ethylene oxide is 3. Other non-limiting examples of anionic surfactants suitable for use in the present invention are: sodium lauryl sulfate, potassium lauryl sulfate, sodium laureth sulfate, potassium laureth sulfate, fatty acid monoglycerides Sulphate, sodium fatty alcohol isethionate, sodium N-lauroyl sarcosine, sodium lauroyl oat amino acid, potassium lauryl phosphate, etc. The nourishing anti-dandruff shampoo composition of the present invention further comprises 1.5% to 8.0%, preferably 2.0% to 6.0%, by weight of the composition, of an amphoteric surfactant suitable for use on the hair or skin, preferably cocamidopropyl betaine. Other non-limiting examples of amphoteric surfactants suitable for use in the present invention include lauryl dimethyl betaine, fatty alcohol polyoxyethylene ether sulfosuccinic acid monoester disodium salt, imidazoline betaine, coconut Sodium Oleamphoacetate, Cocamidopropyl Hydroxybetaine, etc.

The nourishing anti-dandruff shampoo composition of the present invention comprises 0.5% to 5.0% by weight of the composition, preferably 1.0% to 4.0% thickener for suspending the granular anti-dandruff agent and thickening the composition, improving the stability of the shampoo composition Among them, the thickener is preferably phthalic acid amide, the trade name of which is TAB-2, which is prepared by the reaction of dihydrogenated tallow-based secondary amine and phthalic anhydride. Functional suspension stabilizer, which can be used as emulsifier and suspending agent, can effectively stabilize the shampoo composition containing silicone oil and anti-dandruff agent, can be compatible with all components in the composition of the present invention, and has good salt tolerance. A constant thickening effect over a wide pH range allows the composition to have a viscosity of 6000 mPa.s to 12000 mPa.s, preferably 8000 mPa.s to 10000 mPa.s at room temperature. Other non-limiting examples of thickeners suitable for use in the present invention are: sodium chloride, ammonium chloride, monoethanolamine chloride, diethanolamine chloride, sodium sulfate, ammonium sulfate, disodium phosphate, pentasodium phosphate, and other electrolytes And macrogol distearate, macrogol monostearate, macrogol dilaurate, sodium hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose , acrylic acid/polyoxyethylene (20) stearyl ether methacrylic acid copolymer with trade name Aculyn22, acrylic acid copolymer with trade name Aculyn33 and other anionic thickeners, and nonionic thickener C with trade name Aculyn44 ₁₀ polycarbamoyl polyethylene glycol ester, polyethylene glycol, polyvinylpyrrolidone, etc.

The nourishing anti-dandruff shampoo composition of the present invention comprises 2.0% to 10.0% by weight of the composition, preferably 3.0% to 8.0%, of a conditioner suitable for hair and skin, the addition of the conditioner is mainly to improve the hand feel of the hair after washing , making hair smooth, soft and easy to comb. Wherein the conditioning agent is selected from one or more compositions of cationic cellulose polymer, cationic guar gum, and emulsified silicone oil. The cationic cellulose polymer, also known as polycellulose ether quaternary ammonium salt, is a product obtained after quaternization of cellulose or its derivatives, mainly polyquaternium-4, polyquaternium-6 , polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, etc., preferably polyquaternium-10. The cationic guar gum is a product obtained by quaternizing guar gum, and its main component is guar gum propyl trimethyl ammonium chloride, and a series of cationic guar gum can be obtained according to the degree of substitution Product, the preferred degree of substitution is 0.1 to 0.2, the cationic guar gum used in the present invention is under the condition of 25 ℃, the viscosity of its 1% aqueous solution is 2000mPa.s to 4000mPa.s, and its consumption is at 0.02% to 3.0%. Preferably 0.05% to 1.0%; the emulsified silicone oil is non-volatile polydimethylsiloxane, its dosage is 0.5% to 10%, preferably 1.0% to 8.0%, and the emulsified silicone oil used in the present invention is at 25°C The measured viscosity is preferably 100 mPa.s to 2,500,000 mPa.s, more preferably 500 mPa.s to 1,500,000 mPa.s. Select large particle size emulsified silicone oil and small particle size emulsified silicone oil to be used together to improve the dry combability and wet combability of the shampoo. The number average particle diameter of the large particle size emulsified silicone oil is 10 μm to 30 μm, preferably 15 μm to 25 μm; Particle size The number average particle diameter of the emulsified silicone oil is 0.01 μm to 5 μm, preferably 0.01 μm to 2 μm. Non-limiting examples of other conditioners suitable for use herein include: Sodium L-Lactate, Castor Oil Glyceride Maleate, Quaternium-82, Isostearyl Ethylimidazole Ethoxysulfate, Maltamidopropanol methyl ammonium chloride, etc.

B. Anti-dandruff fungicide

The nourishing anti-dandruff shampoo composition of the present invention comprises 0.01% to 3.0%, preferably 0.05% to 2.0%, of an anti-dandruff agent suitable for use on the hair or skin by weight of the composition, and the addition of the anti-dandruff agent improves the anti-dandruff composition of the shampoo composition. Antimicrobial activity. Wherein the anti-dandruff agent is a composition of pyrithione salt and pyridine ketone ethanolamine salt. The trade name of the pyridone ethanolamine salt is SY-OCT (Kunshan Shuangyou Daily Chemical), its structural formula is (I), and its chemical name is: 1-hydroxyl-4-methyl-6-(2,4,4- Trimethylpentyl)-2(1H)-pyridone ethanolamine, which is 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone and A compound of monoethanolamine, wherein the molar ratio of 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone to monoethanolamine is 1:1 :

Pyridone ethanolamine, one of the anti-dandruff and antipruritic agents in the present invention, is safe, non-toxic, non-irritating, and is used in a low amount (generally 0.1-0.75%) in anti-dandruff products. Oxidation and decomposition of oxides and other methods fundamentally block the external factors of dandruff production, not only can effectively kill dandruff-producing yeasts, but also effectively inhibit Grignard positive, negative and various fungi and mold. Compared with zinc pyrithione (ZPT), a commonly used anti-dandruff agent, it has excellent solubility and compounding properties, mild and non-irritating, and will not precipitate or stratify when mixed with cosmetic raw materials.

The structural formula of the pyrithione salt in the present invention is (II), wherein M is a metal ion such as Cu, Zn, Na, etc., preferably M is Zn, that is, zinc pyrithione; the zinc pyrithione is recognized as highly effective and safe It is an anti-dandruff antipruritic agent and a high-efficiency broad-spectrum fungicide, but compared with pyridone ethanolamine (PTO), this compound is more irritating and more irritating to the eyes. In addition, it is extremely difficult to dissolve in organic solvents and water, so it is not suitable for the preparation of transparent shampoos. It is not compatible with EDTA, and its activity will decrease when it encounters non-ionic surfactants. Therefore, when preparing products, it cannot be in contact with EDTA or non-ionic surfactants alone. At the same time, its existence will scatter light, and the shampoo prepared with it will have a certain extinction effect, and the pearlescent effect of the product will be affected. Moreover, when used in shampoo formulations, sedimentation often occurs, and it is easy to change color when encountering iron ions, so suspending agents and stabilizers need to be added. In the present invention, it is preferred that the zinc pyrithione particles have an average particle diameter of at most 10 μm, most preferably at most 5 μm.

In the present invention, the ratio of pyrithionethanolamine to zinc pyrithione is preferably 1:10 to 1:1.5, which can obtain excellent anti-dandruff effect. Other non-limiting examples of anti-dandruff agents suitable for use in the present invention are: undecylenic acid derivatives, 1-(4-chlorophenoxy)-1-(1H-imidazolyl)-3,3-di Methyl-2-butanone, etc.

C. Anti-dandruff synergistic additive

Inhibiting the rate of cell keratinization (reducing the rate of epidermal metabolism) and sterilization are the main ways to prevent and treat dandruff. The main principle of action of the pyrithione salt and pyridine ketone ethanolamine salt composition in the present invention is to inhibit the generation of Pityriasis ovale through its bactericidal action, thereby playing an anti-dandruff effect. However, in real life, due to the existence of factors such as environmental pollution, endocrine and chemical stimulation, the "ecological environment" of the scalp will often be deteriorated. As pointed out in the patent cited in US Patent US5053222, zinc pyrithione (ZPT) Anti-dandruff shampoo has a certain effect on removing dandruff, but it may also cause scalp "ecological disorder" and cause excessive shedding or excessive keratinization of the scalp---one of the other factors of dandruff formation. Therefore, another object of the present invention is to solve the abnormal exfoliation of the scalp so as to reduce the generation of dandruff. US Patent US6110472 discloses a shampoo containing vitamin B12, which is used for the treatment of abnormal scalp exfoliation. The present invention also finds out through a large number of tests that other vitamins such as vitamin E and provitamin B5 can nourish the scalp and hair tip, and prevent the abnormal shedding of the scalp, thereby contributing to the realization of the anti-dandruff function.

Therefore, in addition to the anti-dandruff bactericide in the present invention, it also contains 0.01% to 1.0% by weight of the composition, preferably 0.05% to 0.5%, of an anti-dandruff synergistic additive selected from vitamins such as At least one of vitamin E, provitamin _B5 and vitamin _B12 .

Vitamins contain a range of different organic functional groups such as alcohols, acids, sterols, and quinones. Vitamins can be classified into fat-soluble vitamins and water-soluble vitamins. Fat-soluble vitamins used in daily chemical product compositions include: vitamin A, vitamin D ₂ , vitamin D ₃ , vitamin K ₁ and vitamin E; water-soluble vitamins include: vitamin C, vitamin B ₁ , vitamin B ₂ , Vitamin B ₃ , provitamin B ₅ , vitamin B ₆ , vitamin B ₁₂ etc.

The vitamin E used in the present invention is selected from vitamin E acetate, vitamin E linoleate and vitamin E succinate, and preferably vitamin E acetate (BASF company production), the vitamin E acetate used in the present invention is Fat-soluble vitamins have good antioxidant properties, have clinical effects on hair growth and hair care, help prevent the occurrence of scalp lipid peroxidation, and are helpful in preventing dandruff; the provitamin B ₅ is also known as Panthenol is a water-soluble vitamin and a hydrogenation product of vitamin _B5 . Provitamin _B5 will be converted into vitamin B in the skin and hair, and penetrate deep into the root of the hair to control the moisture in the hair and prevent hair dryness, shedding, Split ends and tangles give hair luster and accelerate hair growth. In addition, provitamin B ₅ has good penetration and moisturizing functions, which helps maintain the balance of scalp moisture, thereby preventing the occurrence of abnormal scalp shedding. Provitamin B ₅ is produced by Roche, preferably with a specific optical rotation of panthenol of +29.0° to +31.5° and a refractive index of 1.495 to 1.502.

In the present invention, vitamin B ₁₂ is a water-soluble vitamin produced by Roche, and its function is to prevent the abnormal shedding of the scalp.

D. Cationic Hydrolyzed Protein

The composition of the present invention further comprises 0.05% to 1%, preferably 0.1% to 0.5%, of cationic hydrolyzed protein, preferably dodecyl to octadecyl dimethyl hydroxypropyl hydrolyzed collagen ammonium chloride, by weight of the composition.

In the present invention, cationic hydrolyzed protein adopts quaternized ammonium hydrolyzed collagen, and reacts with hydrolyzed collagen through long-chain aliphatic hydroxypropyl quaternary ammonium salt to synthesize dodecyl-octadecyl dimethyl hydroxypropyl hydrolyzed collagen chloride Ammonium molecule (referred to as quaternized hydrolyzed collagen hair care concentrate), adopts membrane separation and concentration technology to remove free quaternary ammonium salts and hydrolyzed collagen, and obtain high-quality quaternized hydrolyzed collagen hair care concentrate. The cationic hydrolyzed protein of the present invention contains quaternized active substance at a concentration of 28% to 32%, the quaternized active substance molecule is an amphiphilic cationic compound, the hydrophilic part is hydrolyzed collagen, and the lipophilic part is dodecane to octadecane Dimethyl hydroxypropyl quaternary ammonium salt, the active substance is an ether compound composed of 10-20 amino acid oligopeptides combined with dodecyl-octadecyl dimethyl hydroxypropyl quaternary ammonium salt, with a molecular weight distribution of 1700Da ~3600Da, with moderate molecular weight and strong permeability, it can nourish and repair the damaged part of the hair surface; it can also partially penetrate into the larger damaged cavity inside the hair to directly supplement the basic structural unit of α-keratin- amino acid. Therefore, the cationic hydrolyzed protein used in the present invention is a class of multifunctional surfactants with strong cleaning ability, hair care and bactericidal effect, and plays the role of coordinating and neutralizing the stimulation of other surfactants in the present invention. Thereby contributing to the mild anti-dandruff effect of the system. The cationic hydrolyzed protein (quaternized hydrolyzed collagen) used in the present invention is light yellow transparent liquid, pH 4-6, total nitrogen content 4.0-5.5, active matter content 30±2, produced by Huzhou Huxing Daily Chemical Co., Ltd. .

The composition of the present invention further comprises 0.01% to 3.0%, preferably 0.05% to 1.0% by weight of the composition of a cationic surfactant, preferably behenyltrimethylammonium chloride.

The nourishing anti-dandruff shampoo composition of the present invention also comprises 0.2% to 5.0%, preferably 0.5% to 2.5% of a foam stabilizer by weight of the composition, and the foam stabilizer refers to a surfactant that prolongs and stabilizes foam, mainly selected from alkanolamides, preferably fatty acid monoethanolamides.

The nourishing anti-dandruff shampoo compositions of the present invention may also contain other optional components including chelating agents, pearlizing agents, pH adjusters, preservatives, colors and fragrances, and the like. Non-limiting examples of the chelating agent are: ethylenediaminetetraacetic acid, disodium edetate, tetrasodium edetate, citric acid, phosphoric acid, ascorbic acid, etc., preferably disodium edetate; The non-limiting example of described pearlescent agent has: ethylene glycol stearate, macrogol stearate, preferred sodium ethylene glycol distearate; The non-limiting example of described pH adjuster has: Citric acid, phosphoric acid, etc., preferably citric acid, adjust the pH of the system at 5.0 to 8.0, preferably 5.5 to 6.6; the selection of the preservatives, essences, and pigments meets the requirements of cosmetic hygiene standards, and selects safe raw materials.

In the nourishing anti-dandruff shampoo composition of the present invention, in addition to the above-mentioned components, water is added to the required amount.

Compared with the prior art, the present invention has the following advantages:

The shampoo composition of the present invention contains double anti-dandruff components and anti-dandruff synergistic additives in addition to surfactants, thickeners and conditioning agents contained in conventional shampoos. The double anti-dandruff agent is composed of pyridone olamine salt (PTO) and zinc pyrithione (ZPT), and its scientific ratio is used to bring synergistic and longer-lasting anti-dandruff effect. (PTO+ZPT=BPT anti-dandruff technology).

Preparation

The shampoo compositions of the present invention may be prepared by any known or otherwise effective technique suitable for providing shampoo compositions. Methods of preparing the nourishing anti-dandruff shampoo compositions of the present invention include conventional formulation and mixing techniques.

Instructions

The nourishing anti-dandruff shampoo composition of the present invention is used in the mode of conventional cleaning and conditioning hair, mainly comprises the following steps:

(A) wet the hair with water;

(B) applying to said hair an effective amount of a shampoo composition according to any one of the preceding claims, said effective amount generally being in the range of 1 gram to 50 grams, preferably 2 to 20 grams;

(C) Rinse the shampoo composition from the hair with water.

These steps can be repeated as many times as necessary to achieve the desired cleansing, conditioning and anti-dandruff benefits.

Example

The following are non-limiting examples of nourishing anti-dandruff shampoo compositions of the present invention. These examples are given for the purpose of illustration only, and should not be construed as limiting the present invention, because many changes can be made without departing from the spirit and scope of the present invention. In these examples, all concentrations are percent by weight unless otherwise specified. The term "small amount of material" refers to optional materials such as preservatives, viscosity regulators, pH regulators, spices, pigments, etc., and the selection of these small amount of materials will depend on the specific ingredients selected for the preparation of the present invention. The physical and chemical properties of the ingredients change.

Preparation Examples I-XV

A suitable method for preparing the nourishing anti-dandruff shampoo composition described in Examples I-XV is as follows: Add appropriate amount of water to the reaction tank, add guar gum and polyquaternium-10 under slow stirring to disperse, and slowly Stir and heat to 60°C to 80°C, then add pH regulator (such as citric acid), ammonium lauryl sulfate, ammonium lauryl polyoxyethylene ether sulfate, cocamidopropyl betaine, fatty acid monoethanolamide, ethylene glycol Sodium alcohol distearate, acrylic acid copolymer, phthalic acid amide, disodium edetate (if using these substances), let these substances completely disperse and cool down. When the temperature drops to about 70°C, add anti-dandruff agents pyridine ketone ethanolamine salt and pyrithione zinc successively, after the dispersion is uniform, cool down to below 50°C, add emulsified silicone oil, anti-dandruff synergistic additives to disperse evenly, and then add preservatives, pigments, Essence, etc. Continue to stir to ensure a homogeneous mixture. After adding all the components, viscosity modifiers and pH regulators can be added as needed to adjust the viscosity and pH of the product to an appropriate level. Optionally a small amount of water can be added at the end to make up.

Example Ⅰ-Ⅴ

Embodiment VI-X

As a comparative experiment, the following examples (XI-XV) do not contain pyridone ethanolamine salt, but only zinc pyrithione (ZPT)

Embodiment XI-XV

Example of Efficacy Evaluation

The efficacy evaluation method for embodiment is mainly based on sensory evaluation method.

The sensory evaluation method is as follows: the preparation examples I-XV were distributed to 60 testers for comparison. The testers washed their hair the same way they used the shampoo samples, and used each shampoo for two weeks. The testers scored according to their own feelings. The anti-itch effect was scored according to the time and degree of itching, and the anti-dandruff effect was scored according to the amount and size of dandruff. The scoring standard adopts a 7-point system, 1 point is the worst, 7 points is the best, and the higher the score, the better the effect. The evaluation results of various shampoo compositions are listed in Table 1.

Table 1 Evaluation of the use effect of shampoo composition

Evaluation of the duration of the antidandruff and antipruritic effect:

The sensory evaluation method of the duration of the anti-dandruff effect is: the preparation examples I-XV were distributed to 60 testers for comparison. When the testers use the shampoo samples, they wash their hair in the same way, use it for four consecutive weeks, and use it twice a week; the testers score according to their own feelings, wherein the antipruritic effect and anti-dandruff effect are based on the fifth week after using the embodiment From the first day, the occurrence of initial head itching and initial dandruff was scored. If the itching started on the first day of the fifth week, score 1, the second day, 2 points, and so on, and if it started on the seventh day, score 7 points. Evaluation method of anti-dandruff duration: If dandruff begins to appear on the first day of five weeks, score 1, second day, 2 points, and so on, if dandruff begins to appear on the seventh day, score 7 points.

The scoring standard adopts a 7-point system, 1 point is the worst, 7 points is the best, and the higher the score, the better the effect. Table 2 shows the evaluation results of the use effects of various shampoo compositions.

Table 2 Evaluation of duration of antipruritic and antidandruff effects of shampoo compositions

Claims (1)

1. contain the shampoo composite of two anti-dandruff dose, its component and content are: