CN107308014A

CN107308014A - One kind thickening suspension composition and its application

Info

Publication number: CN107308014A
Application number: CN201710452066.8A
Authority: CN
Inventors: 曾万祥; 覃敢为; 陈海; 陈健; 黄娜
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-06-15
Filing date: 2017-06-15
Publication date: 2017-11-03

Abstract

The present invention relates to one kind thickening suspension composition and its application, belong to daily chemical product.The thickening suspension composition of the present invention includes following components in parts by weight：0.1~0.5 part of the alkylol acrylamide acid esters cross-linked polymers of acrylic acid (ester) class/C10 30,0.05~0.5 part of trihydroxy stearin, 0.1~0.5 part of gellan gum；Present invention also offers a kind of shampoo containing the thickening suspension composition.The thickening suspension composition of the present invention can make product stability more preferable；The anti-dandruff effect of shampoo sterilization of the present invention is good, excellent in stability.

Description

One kind thickening suspension composition and its application

Technical field

The present invention relates to a kind of composition and its application, and in particular to one kind thickening suspension composition and its application.

Background technology

Hair shampoo article has become the necessity in mankind's daily life, commonly used to clean scalp and conditioning hair.Product Good shampoo of fine quality can effectively clean the dirt grease adhered on scalp and hair, meanwhile, also to the nutrition needed for scalp and Protection, comes soft, smooth and glossy to hair carry.But with the progress in epoch, environmental pollution is increasingly serious, people's rhythm of life Also gradually accelerate, daily life system pressure also changes therewith, can not only influence human body endocrine itself to circulate, again result in people's body surface The hair of skin is also influenceed accordingly, thus the security that uses shampoo of people and hair-washing hair-care function have it is higher will The finer classification of summation.The scalp ecological environment of health is maintained by the balance of finance, credits and materials：Grease, flora, metabolic balance.When scalp oil When fat secretion is unbalance, scalp easily fuel-displaced will become greasy thick and heavy；When scalp flora environment is unbalance, bacterium will largely grow Raw, scalp just occurs that head is itched hard to bear phenomenon；When scalp metabolic imbalance, stratum corneum is too fast, causes the too fast shape that comes off Into dandruff.These three balances are once unbalance can all trigger various scalp problems, such as alopecia, dandruff be more and head is itched hard to bear ask Topic.

Existing shampoo uses DMDMH, methylisothiazolinone, methylchloroisothiazandnone conduct mostly Preservative, excitant is larger, and head can be caused to itch and dandruff, and the immediate cause of dandruff is inflammation caused by stimulating.Work as stimulus, The metabolin of such as fungi, comb it is improper, take care of hair improper when causing inflammation, Skin Cell can then accelerate hyperplasia, cause dead skin to take off Fall, that is, our so-called dandruffs.In many cases, the principal element or chlosma amount of dandruff are uneven. Suppress the key that scalp chlosma amount is treatment of dandruff.But anti-dandruff type shampoo is mostly using one kind or two currently on the market Kind of anti-dandruff agent, or be known as and use plant anti-dandruff component, undesirable to elimination chlosma effect, anti-dandruff effect is poor, particularly head The more oily hair of bits, it is more difficult to reach anti-dandruff；Moreover, when using using ZPT as anti-dandruff agent, mostly using single Card ripple class thickening suspending agent, cause product in the quality stability of selling period.Shampoo above can not meet modern Composite request.Therefore, in the shampoo for possessing various hair-washing hair-care functions, wherein preservative free, anti-dandruff excellent effect, production The shampoo of product excellent in stability can receive the welcome and receiving of consumer greatly.

Prior art discloses a kind of Chinese medicine shampoo of relieving itching and removing dandruff, it is made up of the raw material of following mass percent： Lauroyl glucoside hydroxypropyl azochlorosulfonate acid sodium 10%, cocounut oil acyl hydroxyethyl sulfonate 5%, lauroylamidopropyl betaine 8%, cocounut oil acyl Amine 3%, Polyquaternium-10 0.8%, citric acid 0.1-0.3%, coconut oil 2%, dexpanthenol 0.8%, Chinese herbal medicine extract 4-9%, sodium chloride 0.1-0.5%, hydrolyzed wheat protein 0.7%, pantolactone 0.4%, methylisothiazolinone 0.005%, perfume Smart 0.4-0.6%, deionized water surplus.The shampoo of prior art solves existing relieving itching and removing dandruff shampoo and is also easy to produce resistance Property, drug-fast problem, its crowd for being adapted to the scalp problems such as various hair oils, head are itched, dandruff is more uses.But the prior art Have the disadvantage that：The prior art reaches anti-dandruff effect using Chinese herbal medicine extract, although be that natural Chinese medicinal herb is extracted Composition, but individually plant extracts can not but reach the anti-dandruff effect of sterilization of profound level, and anti-dandruff effect slowly effect.Make Preservative is methylisothiazolinone, according to available data inquiry understand, the preservative excitant is larger, be used for a long time or The inappropriate use of person can cause to stimulate Skin Cell, make its epidermis thinning, easily by environmental stimuli, and phylactic power defensive power declines, and makes skin Skin is followed the string gradually, easily produces relaxation, microgroove, and the Skin Cell damaged by preservative constantly defect can then be bred, order Skin quality is worse and worse.And suspending agent is not used in the invention, then the product may be unstable, layering, demulsification, precipitation occurs Etc. phenomenon.In addition, the hair conditioner used in the invention is less, using effect may be poor.

The content of the invention

It is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art and product stability can be made more by providing one kind Good thickening suspension composition and its application.

To achieve the above object, the technical scheme taken of the present invention is：One kind thickening suspension composition, it includes following heavy Measure the component of part：Acrylic acid (ester) class/0.1~0.5 part of C10-30 alkylol acrylamide acid esters cross-linked polymer, trihydroxy stearin 0.05~0.5 part, 0.1~0.5 part of gellan gum.

In above-mentioned thickening suspension composition, effect of each component is：Acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters is handed over Linked polymer refers to the C10-30 alkylol acrylamide acid esters cross-linked polymers in acrylic acid (ester) class.Acrylate crosspolymers Be otherwise known as " carbomer " co-polymer or " carbomer ", is a kind of outstanding thickener and stabilizer in cosmetics, can be with Mobility and transparent feel are provided to gel rubber system.Be not in adverse reaction or some irritating harm.Trihydroxy is stearic Essence is to eat salad oil, the crystallization inhibitor of the oil product such as high grade cooking oil, is the defoamer in yeast production and beet sugar processing, The releasing agent of vegetable oil and shortening, also acts as chelating agent and hair slipping agent etc. in addition.Gellan gum main component is by grape Sugar, glucuronic acid and rhamnose press 2：1：1 ratio, the linear polysaccharide that four kinds of monose are made up of constitutional repeating unit. There is good stability, heat-resisting, resistance to acidolysis, resistance to enzymolysis, the gel being made is even in autoclaving, baking and acidic products condition Under it is all very stable, stirring is dispersed in water, and heating is dissolved into transparent solution, after cooling, forms transparent and solid solidifying Glue.In the presence of cation, hard brittle gel is generated when cooling down after the heating.Influence very little of the heating sterilization to gel.

The thickening suspension composition of the present invention intersects collocation using three kinds of thickening suspending agents, can be with the multiple thickening of highlight products Suspension function, it is ensured that the stability of product is good, is not in the phenomenons such as layering, demulsification, precipitation within the shelf-life.

As the preferred embodiment of thickening suspension composition of the present invention, the thickening suspension composition includes following The component of parts by weight：Acrylic acid (ester) class/0.2 part of C10-30 alkylol acrylamide acid esters cross-linked polymer, trihydroxy stearin 0.2 Part, 0.2 part of gellan gum.Research shows that, containing the specific thickening suspension composition for matching component, it makes product stability most It is good.

Present invention also offers a kind of shampoo containing above-mentioned thickening suspension composition.

As the preferred embodiment of shampoo of the present invention, in the shampoo, the weight of suspension composition is thickened Percentage is 0.2~2.0%.

As the more preferably embodiment of shampoo of the present invention, in the shampoo, the weight of suspension composition is thickened It is 0.6% to measure percentage.Research shows, containing the shampoo that suspension composition is thickened described in certain content, its stability it is further preferred that.

As the preferred embodiment of shampoo of the present invention, the shampoo also going containing following weight percentage Consider agent to be worth doing：ZPT 0.3~3.6%, piroctone olamine salt 0.01~3.5%, hexamidine two (isethionic acid) salt 0.05~3.8%, DM-846 0.1~4.0%, plant anti-dandruff agent 0.5~5.0%；Wherein, the plant anti-dandruff agent is by radix glycyrrhizae Booth acid, saponin(e, azadirachta seed extract and solvent composition；The ZPT, the piroctone olamine salt, (hydroxyl of hexamidine two Ethylsulfonic acid) salt, DM-846 and plant anti-dandruff agent weight sum account for shampoo weight percentage be 1.0~6.0%.

In above-mentioned anti-dandruff agent, effect of each component is as follows：

ZPT is also known as ZPT, Pyrithionc Zinc or 2- pyridine mercaptan -1- oxygen zinc (ZPT), is a kind of colourless solid Body, water is practically insoluble under normal atmosphere temperature neutral, be can be used as preservative, anti-fouling agent, antifungal and anti-dandruff agent etc., be can be used for Treatment of dandruff and seborrhea are closed, and are widely used in the fields such as agricultural, industry, medical and health and cosmetics.Pyrrole sulphur Zinc has stronger killing power to fungi and bacterium, can suppress Gram-negative, positive bacteria and fungus growth, there is stronger Sterilizing ability, can kill the fungi for producing dandruff, it is notable that anti-chlosma suppresses dandruff growth.Therefore it is also referred to as anti-dandruff The factor, can effectively hair conditioning, delay the generation of the aging of hair, control white hair and alopecia.In addition, ZPT is also served as Cosmetics preservative agent, finish, coating biocide.

Piroctone olamine salt, namely anti-dandruff agent OCTO, it is famous because of its bacteriostasis, particularly it can suppress ovale malaria Protozoon, it is parasitized in the scurf of dandruff, face etc..The product is a kind of efficient, nontoxic non-stimulated anti-dandruff agent, can be extensive Anti-dandruff shampoo, hair-nourishing liquid and hair conditioner etc. is used in wash in shield class cosmetics.OCTO anti-dandruff and itching-relieving mechanism be by sterilization and Antioxidation fundamentally blocks the outside channel that dandruff is produced, so that effectively radical cure dandruff, stopping head itching, rather than by de- The modes such as fat temporarily eliminate dandruff from presentation.Here it is one of the reason for OCTO anti-dandruff and itching-relievings performance is better than like product.Should Material identifies very reliable to the security of eyes, skin through external authoritative institution.Absolute non-toxic, excitant and sensitization. In actual use will not damaged scalp, be not in alopecia, disconnected hair.

Hexamidine two (isethionic acid) salt (Pf-95) it is a kind of new water-soluble cationic dandruff-removing itching-relieve Agent, with broad-spectrum antiseptic and bactericidal property, has to various gram-positive bacterias and negative bacterium and various yeast and molds Very high sterilization and bacteriostasis property, especially to the pityrosporum ovale for causing dandruff, because its unique structure has very Strong killing action, and to causing the propionibacterium acnes of acne to have very strong suppression and sterilization effect.And it is very safe Gently, small to skin irritation, the compatibility with conventional raw material in daily chemical products is excellent.Especially because its cationic is to hair The suction-operated of generation, is more beneficial for the reinforcement and persistently performance of its anti-dandruff effect, this is the characteristic that other anti-dandruff agents do not possess. Have extremely important in cosmetics and other industry and be widely applied.

DM-846 has the efficient sterilizing effect of wide spectrum, there is very strong suppression and sterilization effect to the antifungal property of scalp.Energy The Malassezia furfur being attached on scalp is killed, efficient moisturizing effect is provided for scalp, effectively prevents scalp from producing Flakes scurf, can be prevented because the inflammation that allergy is produced causes head to be itched；Excessive degreasing is prevented, dry scalp causes to produce scurf. There are anti-inflammatory, resistance state effect.Sterilization, fungistatic effect to the preservative that is added in product play the role of synergy, so as to reduce The excitant and anaphylaxis of product.

Enoxolone is classical anti-inflammatory drug in plant anti-dandruff agent (glycyrrhetinic acid, saponin(e, azadirachta seed extract).Have The effects such as anti-inflammatory antiallergy, suppression bacterial reproduction, can adjust the immunologic function of skin, strengthen the resistance against diseases of skin, eliminate inflammation Disease, pre- hypo-allergenic, cleaning skin, can release the toxic side effect of cosmetics and other extraneous factors to skin.Saponin(e has antibacterial Active or antipyretic, calm, antitumor, anti-inflammatory, immunological regulation, the sub, liver-protecting activity of antiviral, antimycotic, spermicidal etc. are valuable Bioactivity.Margosa tree possesses sterilization and antiviral characteristic and desinsection, effect of sterilizing.

The anti-dandruff agent that shampoo of the present invention is used is ZPT (ZPT), piroctone olamine salt (OCTO), hexamidine Two (isethionic acid) salt (Pf-95), DM-846, plant anti-dandruff agent (glycyrrhetinic acid, saponin(e, azadirachta seed extract) Five kinds of different types of anti-dandruff agents are compound to match.Chemical anti-dandruff agent is combined by the present invention with plant anti-dandruff agent, not only reduces it Stimulation to scalp, while can reach best anti-dandruff effect again, highlights multiple anti-dandruff effect.Five kinds of anti-dandruff agents, even more pass through The proportioning of multiple various dose, tests its anti-dandruff effect in shampoo, so as to show that optimal components ratio reaches that deep layer is sterilized Anti-dandruff effect.

As the more preferably embodiment of shampoo of the present invention, the shampoo contains going for following weight percentage Consider agent to be worth doing：ZPT 1.3%, piroctone olamine salt 0.2%, hexamidine two (isethionic acid) salt 0.1%, DM-846 0.4%th, plant anti-dandruff agent 1.5%.By many experiments, the shadow that component proportion sterilizes anti-dandruff effect to shampoo is compared repeatedly Ring, find under the specific content, shampoo of the invention can reach optimal deep layer and sterilize anti-dandruff effect.

It is used as the more preferably embodiment of shampoo of the present invention, the glycyrrhetinic acid, saponin(e, azadirachta seed extract Mass ratio with solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.Wherein, azadirachta seed is extracted Thing can be by being commercially available.

As the preferred embodiment of shampoo of the present invention, group of the shampoo also containing following weight percentage Point：Surfactant 18~30%, hair conditioner 0.3~5.0%, preservative 0.3~0.8%, surplus is water.The shampoo Shampoo is a kind of without anti-corrosion, multiple-effect be anti-dandruff, excellent in stability new hair shampoo article, the need for it can meet people's cleaning, Keep shampoo is effectively anti-dandruff to stop to the nutrition and protection needed for scalp, while coming soft, smooth and glossy to hair carry Itch, reach or close to the anti-dandruff effect of medicine adornment.

At least one of as the preferred embodiment of shampoo of the present invention, in following (a)~(c)：

(a) shampoo contains the surfactant of following weight percentage：Laureth sodium sulfovinate or bay Alcohol polyethers sulfuric ester ammonium 13~18%, laruyl alcohol sodium sulfovinate or bay alcohol sulfuric ester ammonium 4~8%, cocamidopropyl propyl amide beet Alkali 1~3%, tallow fatty acid sodium 1~3%, coconut oleoyl amine DEA 0.5~1.5%, coconut oleoyl amine MEA 0.5~2.5%；

(b) shampoo contains the hair conditioner of following weight percentage：Behenyl base trimethyl ammonium chloride or hard ester Base trimethyl ammonium chloride 0.1~0.5%, guar hydroxypropyltrimonium chloride 0.1~0.6%, polyquaternium -7 1~ 5%th, Polyquaternium-10 0.05~0.3%, ring five dimethyl silicone polymer, cyclomethicone or polydimethylsiloxanes Alkane 0.5~2.5%, panthenol 0.1~1%, aminoethylaminopropyl dimethyl silicone polymer or ammonia end dimethyl silicone polymer 0.5~ 2.5%th, hydrolysis silk 0.5~1.5%, allantoin 0.1~0.5%, Etidronic Acid 0.05~0.15%, EDETATE SODIUM 0.05 ~0.15%, phytosterol Queensland nut oleate 0.2~0.8%, C12-13 alcohol lactate 0.2~0.8%, cocoyl glucose Glycosides 0.2~2%, silk glue protein 0.2~1.2%, dipentaerythritol pentaerythritol tetraisostearate 0.2~0.8%, glyceryl oleate 0.2~1.2%, Anjidew NL50 or glycerine 1~5%；

(c) preservative is made up of decoyl hydroximic acid, parahydroxyacet-ophenone, the sad fat of glycerine and butanediol.

Foregoing preservatives are natural no added non-stimulated, and efficient natural is gentle, may be substituted for traditional preservatives, and reduction is passed The infringement that preservative of uniting comes to skin tape.Wherein, decoyl hydroximic acid is more effective to mould, an unbounded quantity of to require, and excitant It is low, and the compatibility of cosmetic material is preferable.In addition, it has chelating Ca²⁺,Fe²⁺And Fe³⁺Effect, it is possible to reduce metal ion Concentration.Parahydroxyacet-ophenone is a kind of natural plant extracts, is naturally occurring in stem, the leaf of feverfew artemisia scoparia, Artemisia capillaris, In the root of the plants such as Asclepiadaceae plant, kerr tylophora root.It is the safest high temperature of current the world of medicine to application on human skin without any harm Auxiliary activity stabilizer, is used in cosmetic industry mainly as preservative, is widely used in medicine, cosmetics, industry Field.Glycerol caprylate is a kind of novel non-toxic high-efficiency broad spectrum preservative.It has suppression to make to gram- bacteria, mould, yeast With, have anti-corrosion and emulsification dual-use function, be can be used for emulsion, surfactant product, the product of water alcohol system, have antibacterial, guarantor The effects such as wet, stuffing, it is mainly used in antiseptic and emulsifying agent in food, cosmetics and medical industry.Butanediol is polyalcohol One kind, often do NMF and solvent is used in cosmetics, in terms of moisturizing, because butanediol is small molecule moisturizing composition, So water ratio very little is grabbed, while also there is certain bacteriostasis.Security is worth affirmative, will not produce irritable inflammation.

As the preferred embodiment of shampoo of the present invention, the shampoo also contains essence, and the essence is being washed Percentage by weight in becoming visible is 0.5~1.5%.By adding essence, the smell of shampoo can be improved.

Compared with prior art, beneficial effects of the present invention are：

The shampoo of the present invention, it contains the thickening suspension composition of the present invention, and its stability is more preferable.The hair washing of the present invention Dew is further containing kind of an anti-dandruff agent is whether there is, and the anti-dandruff effect of its antibacterial is good.

Brief description of the drawings

Fig. 1 is embodiment 4~6 three kind shampoo bacteriostatic experiment flat board figure；

Fig. 2 is embodiment 4, six kinds of shampoo bacteriostatic experiment flat board figures of comparative example 1~5；

Fig. 3 is three kinds of shampoo dew stability experiment figures described in embodiment 9；

Fig. 4 is seven kinds of shampoo dew stability experiment figures described in embodiment 10.

Embodiment

For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention It is described further.

In following embodiments 4~6 and embodiment 12~15, the DM-846 is made up of the component of following weight percentage： Dichlorbenzyl alcohol 18-20%, isostearoyl dilactic acid sodium 5-7%, cocamidopropyl propyl amide pg dimonium chloride 68-70%, Sodium lactate 5-7%.

Embodiment 1

A kind of embodiment of present invention thickening suspension composition, thickening suspension composition includes following heavy described in the present embodiment Measure the component of part：Acrylic acid (ester) class/0.2 part of C10-30 alkylol acrylamide acid esters cross-linked polymer, 0.2 part of trihydroxy stearin, 0.2 part of gellan gum.

The thickening suspension composition of the present embodiment is to mix above-mentioned each component in proportion.

The shampoo of the present embodiment contains above-mentioned thickening suspension composition, and in shampoo, thickens the weight of suspension composition It is 0.6% to measure percentage.Further, anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：Pyrrole sulphur Zinc 1.3%, piroctone olamine salt 0.2%, hexamidine two (isethionic acid) salt 0.1%, DM-846 0.4%, plant go Consider agent 1.5% to be worth doing；Wherein, the DM-846 is by dichlorbenzyl alcohol, isostearoyl dilactic acid sodium, cocamidopropyl propyl amide PG- diformazans Ammonium chloride and sodium lactate composition, the dichlorbenzyl alcohol, isostearoyl dilactic acid sodium, cocamidopropyl propyl amide PG- dimethyl The weight ratio of ammonium chloride and sodium lactate is dichlorbenzyl alcohol：Isostearoyl dilactic acid sodium：Cocamidopropyl propyl amide PG- dimethyl chlorides Change ammonium：Sodium lactate=18：7：68：7；Plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent；Institute The mass ratio for stating glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：It is molten Agent=1：1：3：5.

Embodiment 2

A kind of embodiment of present invention thickening suspension composition, thickening suspension composition includes following heavy described in the present embodiment Measure the component of part：Acrylic acid (ester) class/0.1 part of C10-30 alkylol acrylamide acid esters cross-linked polymer, 0.05 part of trihydroxy stearin, 0.5 part of gellan gum.

The shampoo of the present embodiment contains above-mentioned thickening suspension composition, and in shampoo, thickens the weight of suspension composition It is 2.0% to measure percentage.Further, anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：Pyrrole sulphur Zinc 0.3%, piroctone olamine salt 0.01%, hexamidine two (isethionic acid) salt 0.09%, DM-846 0.1%, plant Anti-dandruff agent 0.5%；Wherein, the DM-846 is by dichlorbenzyl alcohol, isostearoyl dilactic acid sodium, cocamidopropyl propyl amide PG- bis- Ammonio methacrylate and sodium lactate composition, the dichlorbenzyl alcohol, isostearoyl dilactic acid sodium, cocamidopropyl propyl amide PG- diformazans The weight ratio of ammonium chloride and sodium lactate is dichlorbenzyl alcohol：Isostearoyl dilactic acid sodium：Cocamidopropyl propyl amide PG- dimethyl Ammonium chloride：Sodium lactate=20：5：70：5；Plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent； The glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and solvent are glycyrrhetinic acid：Saponin(e：Azadirachta seed extract： Solvent=1：1：3：5.

Embodiment 3

A kind of embodiment of present invention thickening suspension composition, thickening suspension composition includes following heavy described in the present embodiment Measure the component of part：Acrylic acid (ester) class/0.5 part of C10-30 alkylol acrylamide acid esters cross-linked polymer, 0.5 part of trihydroxy stearin, 0.1 part of gellan gum.

The shampoo of the present embodiment contains above-mentioned thickening suspension composition, and in shampoo, thickens the weight of suspension composition It is 0.2% to measure percentage.Further, anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：Pyrrole sulphur Zinc 3.6%, piroctone olamine salt 0.05%, hexamidine two (isethionic acid) salt 0.05%, DM-846 0.3%, plant Anti-dandruff agent 2.0%；Wherein, the DM-846 is by dichlorbenzyl alcohol, isostearoyl dilactic acid sodium, cocamidopropyl propyl amide PG- bis- Ammonio methacrylate and sodium lactate composition, the dichlorbenzyl alcohol, isostearoyl dilactic acid sodium, cocamidopropyl propyl amide PG- diformazans The weight ratio of ammonium chloride and sodium lactate is dichlorbenzyl alcohol：Isostearoyl dilactic acid sodium：Cocamidopropyl propyl amide PG- dimethyl Ammonium chloride：Sodium lactate=19：6：69：6；Plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent； The glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and solvent are glycyrrhetinic acid：Saponin(e：Azadirachta seed extract： Solvent=1：1：3：5.

Embodiment 4

A kind of embodiment of shampoo of the present invention, shampoo described in the present embodiment it is main by following weight than preparing raw material It is prepared from：

Surfactant：Laureth sodium sulfovinate 16%, laruyl alcohol sodium sulfovinate 4%, cocamidopropyl propyl amide beet Alkali 2%, tallow fatty acid sodium 1%, coconut oleoyl amine DEA 0.5%, coconut oleoyl amine MEA 1.5%；

Hair conditioner：Behenyl base trimethyl ammonium chloride 0.2%, guar hydroxypropyltrimonium chloride 0.3%, poly- season Ammonium salt -7 3%, Polyquaternium-10 0.1%, dimethyl silicone polymer 1%, panthenol 0.5%, aminoethylaminopropyl poly dimethyl Siloxanes 2%, hydrolysis silk 0.3%, allantoin 0.2%, Etidronic Acid 0.05%, EDETATE SODIUM 0.05%, phytosterol Queensland nut oleate 0.3%, C12-13 alcohol lactate 0.3%, cocoyl glucoside 1.5%, silk glue protein 0.5%, two Polypentaerythritol pentaerythritol tetraisostearate 0.3%, glyceryl oleate 0.8%, glycerine 3%；

Anti-dandruff agent：ZPT 1.3%, piroctone olamine salt 0.2%, hexamidine two (isethionic acid) salt 0.1%th, DM-846 0.4%, plant anti-dandruff agent 1.5%；Wherein, the plant anti-dandruff agent is by glycyrrhetinic acid, saponin(e, azadirachta Seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and water are glycyrrhetin Acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5；

Thicken suspension composition：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy Stearin 0.2%, gellan gum 0.2%；

Preservative 0.6%, wherein, preservative is by decoyl hydroximic acid, parahydroxyacet-ophenone, the sad fat of glycerine and butanediol group Into；

PH adjusting agent：Citric acid 0.1%, sodium hydroxide 0.1%.

The preparation method of shampoo described in the present embodiment is：

(1) all production apparatus are cleaned and disinfected with water, autoclave sterilization is carried out to emulsification pot group Processing；

(2) ratio adds deionized water in emulsification pot in formula, 80~85 DEG C is then heated to, according to the weight of raw material Amount percentage weighs raw material, first adds laureth sodium sulfovinate and laruyl alcohol sodium sulfovinate, tallow fatty acid sodium, coconut oleoyl amine DEA, is evacuated to after -0.06~-0.08MPa, and then 10~15min of its homogeneous is added into mountain to uniform under stirring at low speed Yu base trimethyl ammonium chlorides, add the scattered guar hydroxypropyltrimonium chloride of 20 times of cold pure water, add 20 times of cold pure water Scattered gellan gum, adds the scattered Polyquaternium-10 of 20 times of cold pure water, and 5~10min of homogeneous adds trihydroxy hard to uniform Fat essence composition, moderate-speed mixer is incubated 30 minutes, adds acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters crosslinking poly- The compound aqueous solution starts cooling while stirring；

(3) said components are cooled, temperature adds panthenol, C12-13 alcohol lactates, allantois when being down to 45~50 DEG C Element, Etidronic Acid, EDETATE SODIUM to emulsification pot, middling speed is stirred always；

(4) said components are cooled, temperature adds polyquaternium -7 when being down to 40~45 DEG C, hydrolyzes silk, plant Sterol Queensland nut oleate, cocoyl glucoside, silk glue protein, dipentaerythritol pentaerythritol tetraisostearate, glycerine oleic acid Ester, essence, ZPT, piroctone olamine salt, hexamidine two (isethionic acid) salt, DM-846, glycyrrhetinic acid, soap Glycosides, azadirachta seed extract, HL-01 (the sad fat of decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine, butanediol) is stirred to emulsification pot 30~45min is mixed to uniform；

(5) acid-base modifier-citric acid and sodium hydroxide are weighed in ratio in formula, is tuned into the addition of 30% solution by portions Emulsify in pot, regulation pH (straight to survey) to 5.5~6.0；

(6) Cocoamidopropyl betaine is weighed in ratio in formula, be added in emulsification pot, regulation viscosity to 10000 ~15000mp.s, reaches discharged after product inner quality standard after testing.

Wherein, the process for preparation of trihydroxy stearin composition：Ratio adds cocounut oil acyl in oil phase pot is in formula first Amine MEA, glycerine then heats to 80~85 DEG C, is stirring evenly and then adding into trihydroxy stearin, standby after moderate-speed mixer is uniform； The process for preparation of acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer aqueous solution：By in formula in aqueous phase pot Ratio adds 30% deionized water, adds acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers, makes it naturally molten Sink in water, be heated to 35~40 DEG C, after stir it is standby.

Embodiment 5

Anti-dandruff agent：ZPT 1.0%, piroctone olamine salt 0.3%, hexamidine two (isethionic acid) salt 0.05%th, DM-846 0.5%, plant anti-dandruff agent 1.0%；Wherein, the plant anti-dandruff agent is by glycyrrhetinic acid, saponin(e, azadirachta Seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and water are glycyrrhetin Acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5；

Preservative 0.6%, preservative is made up of decoyl hydroximic acid, parahydroxyacet-ophenone, the sad fat of glycerine and butanediol；

PH adjusting agent：Citric acid 0.1%, sodium hydroxide 0.1%.

The preparation method be the same as Example 4 of shampoo described in the present embodiment.

Embodiment 6

Anti-dandruff agent：ZPT 0.5%, piroctone olamine salt 0.3%, hexamidine two (isethionic acid) salt 0.3%th, DM-846 0.2%, plant anti-dandruff agent 0.5%；Wherein, the plant anti-dandruff agent is by glycyrrhetinic acid, saponin(e, azadirachta Seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and water are glycyrrhetin Acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5；

PH adjusting agent：Citric acid 0.1%, sodium hydroxide 0.1%.

Embodiment 7

The present embodiment tests the suppression for comparing embodiment 4~6 three kind shampoo by plate dilution method bacteria growing inhibiting Bacterium effect.The specific method compared is：The fungistatic effect of above-mentioned three kinds of shampoos is intuitively observed using the size of inhibition zone, point Not numbering B, C, D.Wherein numbering is A for the measure control group that is carried out in the case of without shampoo.Take the logarithm the phase (OD_600nm0.5) bacterium (being extracted from scalp), 1.0 × 10 are diluted to LB culture mediums⁷CFU/mL.Take after 20 μ L dilutions Bacterium solution is added in LB culture mediums, is then uniformly layered on after the first-class culture medium solidifying of flat board, then will the different hair washings of three kinds of immersion The scraps of paper of water sample are placed on culture medium, overnight incubation (every group of at least three times repetition) at 37 DEG C.It is big by observing inhibition zone It is small to judge its antibacterial activity.Observation experiment result is shown in Fig. 1.

Experimental result is：Flat-plate experimental result shows to compare for control group A, and (numbering is for the shampoo of embodiment 4：B) Have for obvious fungistatic effect, and its effect of combination and price, its cost performance highest, collocation is most reasonable.Embodiment 5 is washed Becoming visible, (numbering is：C) also there is fungistatic effect, but it is obvious apparently without the first.(numbering is the shampoo of embodiment 6：D) press down Bacterium effect is more obvious than the shampoo C of embodiment 5, although its cost is low compared with B, not than the hair washing dew B effects of embodiment 4 It is good, therefore cost performance is not high.So, the shampoo antibacterial effect of embodiment 4 is best, cost performance highest.

Embodiment 8

The present embodiment compares the shampoo of embodiment 4 and the shampoo of comparative example 1~5, investigated it is anti-dandruff into Divide the influence to shampoo fungistatic effect.

Composition contained by the shampoo of comparative example 1~5, in addition to anti-dandruff agent is different from embodiment 4, other with the phase of embodiment 4 Together.In comparative example 1, the anti-dandruff agent in ZPT (ZPT) replacement embodiment 4 to account for shampoo weight 3.5%；Comparative example 2 In, the anti-dandruff agent in piroctone olamine salt (OCTO) replacement embodiment 4 to account for shampoo weight 3.5%；Comparative example 3 In, with account for shampoo matter weight 3.5% hexamidine two (isethionic acid) salt (Pf-95) replace in embodiment 4 Anti-dandruff agent；In comparative example 4, to account for the DM-846 of shampoo weight 3.5% instead of the anti-dandruff agent in embodiment 4；In comparative example 5, With account for shampoo weight 3.5% plant anti-dandruff agent replace embodiment 4 in anti-dandruff agent, and plant anti-dandruff agent by glycyrrhetinic acid, Saponin(e, azadirachta seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the quality of azadirachta seed extract and water Than for glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5.

The suppression for the shampoo for comparing embodiment 4 and comparative example 1~5 is tested by plate dilution method bacteria growing inhibiting Bacterium effect.The fungistatic effect of six kinds of shampoo of contrast and control group is intuitively observed using the size of inhibition zone, is numbered respectively A, b (comparative example 1), c (comparative example 2), d (comparative example 3), e (comparative example 4), f (comparative example 5), g (embodiment 4), wherein numbering a For the measure control group carried out in the case of without shampoo.Take the logarithm the phase (OD_600nm0.5) bacterium (carries from scalp Take), it is diluted to 1.0 × 10 with LB culture mediums⁷CFU/mL.The bacterium solution after 20 μ L dilutions is taken to be added in LB culture mediums, Ran Houjun Even is layered on after the first-class culture medium solidifying of flat board, then the different scraps of paper for having one's hair wash water samples of six kinds of immersion are placed on culture medium, Overnight incubation (every group of at least three times repetition) at 37 DEG C.Judge its antibacterial activity by observing inhibition zone size.Observation experiment As a result Fig. 2 is seen.Experimental result：Flat-plate experimental result shows that the shampoo containing compound anti-dandruff agent (is numbered compared to for control group a For：G) than the shampoo of independent anti-dandruff agent, (numbering is：B, c, d, e, f) there is more obvious fungistatic effect, illustrate containing optimal ratio The compounding anti-dandruff agent shampoo of example is more preferable than the shampoo antibacterial effect containing single anti-dandruff agent.

Embodiment 9

The present embodiment by cyclical stability testing research tri- kinds of a~c containing different proportion compounding thickening suspension composition Shampoo stability.Wherein, a is shampoo described in embodiment 4；B and c except thickening suspending agent it is different from a in addition to, other with A is identical.Thickening suspending agent containing following weight percentage in shampoo b：Acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters is handed over Linked polymer 0.1%, trihydroxy stearin 0.1%, gellan gum 0.1%；Thickening containing following weight percentage in shampoo c is hanged Floating agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.3%, trihydroxy stearin 0.3%, gellan gum 0.3%.

Cyclical stability test specific method be：

(1) that the above-mentioned three kinds test samples containing different proportion composite thickening suspending agent are attached separately into three 80ml is transparent In cup (charging 70ml)；

(2) three samples are subjected to high/low temperature loop test (three circulations) respectively, " circulation " refers to：Take these three samples Product, are placed in 48 DEG C of insulating boxs after 24 hours, and taking out placement room temperature makes sample recover room temperature for 24 hours, then puts it into -15 24 hours in DEG C refrigerator, then it is drawn off placing room temperature and sample is recovered room temperature.Then to product appearance, smell, hand Sense, pH value and viscosity are tested.Observation experiment the results are shown in Table shown in 1 and Fig. 3.

Experimental result：

Stability experiment result is judged by the project of chart 1, and it carries out outside drawing such as Fig. 3 institutes before and after stability test Show, test result indicates that (numbering is the shampoo product (water material) of the composite thickening suspending agent containing embodiment 4：A) result of variations Grade be 1 grade, with reference to outside drawing it can be found that：Its color sample, glossiness are unchanged；Without demulsification, precipitation, layering, floccule Separate out the phenomenons such as suspension, muddiness, stain, sweating, floating material；The phenomenons such as non-pigment, shimmering powder skewness；Fragrance is constant；It is soft or hard Degree is constant, and pH value and viscosity value changes are also little, illustrates that it thickens suspension effect very well, the ratio of three kinds of thickening suspending agents Collocation is reasonable.Shampoo b and shampoo c result of variations grade are 2 grades, and discovery is combined with outside drawing：Its effect and the first phase Than weaker, its color has change somewhat, and gloss also slightly changes；Fragrance is slightly thin out；The slightly a little change of soft or hard degree；But It is also to separate out the phenomenons such as suspension, muddiness, stain, sweating, floating material without demulsification, precipitation, layering, floccule；Non-pigment, shimmering powder point The unequal phenomenon of cloth.Therefore shampoo b and shampoo c suspension effect does not have the shampoo of embodiment 4 good.

Table 1

Note：PH and the changing value of viscosity can be raised and can also reduced in table 1, i.e.,

PH value：Value-initial value ︱ after change=︱ experiments；Viscosity：Value-initial value ︱/initial value after rate of change=︱ experiments.

Embodiment 10

Seven kinds of A~G thickens the shampoo of suspending agents containing different proportion to the present embodiment by cyclical stability testing research Stability.Wherein, A is shampoo described in embodiment 4；B~G is in addition to thickening suspending agent is different from A, and other are identical with A.Wash Become visible the thickening suspending agent containing following weight percentage in B：Trihydroxy stearin 0.2%, gellan gum 0.2%；Contain in shampoo C There is the thickening suspending agent of following weight percentage：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, knot Cold glue 0.2%；Thickening suspending agent containing following weight percentage in shampoo D：Acrylic acid (ester) class/C10-30 alkylol acrylamides acid Ester cross-linked polymer 0.2%, trihydroxy stearin 0.2%；Thickening suspending agent containing following weight percentage in shampoo E：Three Oxystearin 0.6%；Thickening suspending agent containing following weight percentage in shampoo F：Acrylic acid (ester) class/C10-30 alkanols Acrylate crosspolymers 0.6%；Thickening suspending agent containing following weight percentage in shampoo G：Gellan gum 0.6%.

Cyclical stability test specific method be：

(1) the above-mentioned seven kinds test samples containing different thickening suspending agents are attached separately to the (charging of seven transparent cups of 80ml In 70ml), numbering A, B, C, D, E, F, G respectively.

(2) seven samples are subjected to high/low temperature loop test (three circulations) respectively, " circulation " refers to：Take this seven samples Product, are respectively placed in 48 DEG C of insulating boxs after 24 hours, and taking out placement room temperature makes sample recover room temperature for 24 hours, is then put Enter in -15 DEG C of refrigerators 24 hours, then being drawn off placement room temperature makes sample recover room temperature for 24 hours.Then to product appearance, gas Taste, feel, pH value and viscosity are tested.Observation experiment the results are shown in Table shown in 1 and Fig. 4.

Experimental result：

Stability experiment result is judged by the project of chart 1, and it carries out outside drawing such as Fig. 4 institutes before and after stability test Show, test result indicates that the result of variations grade of the shampoo product (water material) (numbering is A) containing three kinds of composite thickening suspending agents For 1 grade, with reference to outside drawing it can be found that：Its color sample, glossiness are unchanged；Separated out without demulsification, precipitation, layering, floccule The phenomenon such as suspension, muddiness, stain, sweating, floating material；The phenomenons such as non-pigment, shimmering powder skewness；Fragrance is constant；Soft or hard degree Constant, pH value and viscosity value changes are also little, illustrate that it thickens suspension effect very well, the ratio collocation of three kinds of thickening suspending agents Rationally.The result of variations grade of three shampoo products (water material) (numbering is B, C, D) containing two kinds of composite thickening suspending agents is 3 Level, discovery is combined with outside drawing：Its effect is weaker compared with containing three kinds of composite thickening suspending agents, and its color has change somewhat Change, gloss also slightly changes；Fragrance is thin out more apparent；Soft or hard degree is relatively changed；PH value and viscosity number have a little change, mucus There is demulsifying phenomenon, shimmering powder sinks or floats more apparent；But also separated out without layering, precipitation, floccule suspend, pigment sinks, it is muddy, The phenomenons such as stain, sweating, floating material.The other three comprises only a kind of shampoo product (water material) for thickening suspending agent, and (numbering is E, F, G) result of variations grade be 4 grades, discovery is combined with outside drawing：Its effect than containing two kinds of composite thickening suspending agents more Difference, its color sample changes very greatly；Fragrance is thin out it is obvious that soft or hard degree significant change；PH value and viscosity number are changed greatly, Product have layering, precipitation, floccule separate out suspend, pigment sinks, become under muddy or transparent, stain, sweating, floating material, shimmering powder The heavy or phenomenon such as obvious that floats.These results show that single thickening suspending agent and the combination of any two kinds of thickenings suspending agent are increasing The three kinds of compounding thickening suspending agents combined containing optimal proportion are all less than on thick suspension effect.

Embodiment 11

Choose shampoo described in embodiment 4 and carry out using effect detection, gained Testing index is as follows：

1st, anaphylaxis is stimulated to detect

Shampoo described in embodiment 4 is sampled, it is applied in right amount on volunteer (18-58 Sui, 30 people) the back of the hand and observed 30min, sees whether it the phenomenons such as redness, dermexanthesis, foaming occurs, observation indicate that, in 30min and all testers do not go out Existing ill symptomses, illustrating that this product will not be produced to skin stimulates and allergy sex chromosome mosaicism.

2nd, dandruff control shampoo containing resultant effect is detected

Using opinion poll point system, by asking volunteer to try out this product and filling in table on probation come overall merit embodiment 4 The anti-dandruff shampoo.Volunteer (the people of 18-38 age brackets 50 of different age group is chosen respectively；The people of 38-58 age brackets 50) make To try out object, hair washing in every two days is once, continuous to use three months, fills in table on probation after trying out and is scored.It is each in grade form Evaluation item judges with the number of different evaluation in personal assessment, altogether 100 people.Every using effect situation of shampoo It is shown in Table 2.

Every using effect situation of the embodiment shampoo of table 2

It can be drawn from the test result of table 2：Shampoo of the present invention is not only non-stimulated, and is had using rear hair Extraordinary anti-dandruff effect, easily cleaning, and clearly, it is submissive and glossy, illustrate that shampoo of the present invention has deep layer Debris removing, cleans scalp, moistens effect of hair, and long-term use can cause hair without dandruff, submissive beautiful glossy.

Embodiment 12

A kind of embodiment of shampoo of the present invention, the shampoo of the present embodiment contains the component of following weight percentage：Increase Thick suspension composition 0.6%；The thickening suspension composition includes following components in parts by weight：Acrylic acid (ester) class/C10-30 0.2 part of alkylol acrylamide acid esters cross-linked polymer, 0.2 part of trihydroxy stearin, 0.2 part of gellan gum；

Anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：ZPT 1.3%, piroctone second Alcohol amine salt 3.5%, hexamidine two (isethionic acid) salt 0.2%, DM-846 0.2%, plant anti-dandruff agent 0.5%；Wherein, institute Plant anti-dandruff agent is stated to be made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent；The glycyrrhetinic acid, saponin(e, azadirachta The mass ratio of seed extract and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.

Embodiment 13

Anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：ZPT 0.3%, piroctone second Alcohol amine salt 0.3%, hexamidine two (isethionic acid) salt 3.8%, DM-846 0.2%, plant anti-dandruff agent 0.5%；Wherein, institute Plant anti-dandruff agent is stated to be made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent；The glycyrrhetinic acid, saponin(e, azadirachta The mass ratio of seed extract and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.

Embodiment 14

Anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：ZPT 1.0%, piroctone second Alcohol amine salt 0.3%, hexamidine two (isethionic acid) salt 0.2%, DM-846 4.0%, plant anti-dandruff agent 0.5%；Wherein, institute Plant anti-dandruff agent is stated to be made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent；The glycyrrhetinic acid, saponin(e, azadirachta The mass ratio of seed extract and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.

Embodiment 15

Anti-dandruff agent of the shampoo of the present embodiment also containing following weight percentage：ZPT 0.3%, piroctone second Alcohol amine salt 0.01%, hexamidine two (isethionic acid) salt 0.09%, DM-846 0.1%, plant anti-dandruff agent 5.0%；Wherein, The plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent；The glycyrrhetinic acid, saponin(e, India The mass ratio of chinaberry seed extract and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.

Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention And scope.

Claims

1. one kind thickening suspension composition, it is characterised in that：Including following components in parts by weight：Acrylic acid (ester) class/C10-30 0.1~0.5 part of alkylol acrylamide acid esters cross-linked polymer, 0.05~0.5 part of trihydroxy stearin, 0.1~0.5 part of gellan gum.

2. suspension composition is thickened as claimed in claim 1, it is characterised in that：Including following components in parts by weight：Acrylic acid (ester) class/0.2 part of C10-30 alkylol acrylamide acid esters cross-linked polymer, 0.2 part of trihydroxy stearin, 0.2 part of gellan gum.

3. a kind of contain the shampoo that suspension composition is thickened as described in any one of claim 1~2.

4. shampoo as claimed in claim 3, it is characterised in that：In the shampoo, the weight hundred of suspension composition is thickened Divide than being 0.2~2.0%.

5. shampoo as claimed in claim 4, it is characterised in that：In the shampoo, the weight hundred of suspension composition is thickened Divide than being 0.6%.

6. shampoo as claimed in claim 4, it is characterised in that：The shampoo is also containing the anti-dandruff of following weight percentage Agent：ZPT 0.3~3.6%, piroctone olamine salt 0.01~3.5%, hexamidine two (isethionic acid) salt 0.05 ~3.8%, DM-846 0.1~4.0%, plant anti-dandruff agent 0.5~5.0%；Wherein, the DM-846 is by following weight percentage The component composition of ratio：Dichlorbenzyl alcohol 18-20%, isostearoyl dilactic acid sodium 5-7%, cocamidopropyl propyl amide PG- dimethyl Ammonium chloride 68-70%, sodium lactate 5-7%；Plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent； The ZPT, piroctone olamine salt, hexamidine two (isethionic acid) salt, the weight of DM-846 and plant anti-dandruff agent The percentage that sum accounts for shampoo weight is 1.0~6.0%.

7. shampoo as claimed in claim 6, it is characterised in that：The shampoo contains the anti-dandruff of following weight percentage Agent：ZPT 1.3%, piroctone olamine salt 0.2%, hexamidine two (isethionic acid) salt 0.1%, DM-846 0.4%th, plant anti-dandruff agent 1.5%.

8. shampoo as claimed in claims 6 or 7, it is characterised in that：The glycyrrhetinic acid, saponin(e, azadirachta seed extract Mass ratio with solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.

9. the shampoo as described in any one of claim 4~8, it is characterised in that：The shampoo also contains following weight hundred Divide the component of ratio：Surfactant 18~30%, hair conditioner 0.3~5.0%, preservative 0.3~0.8%, surplus is water.

10. shampoo as claimed in claim 9, it is characterised in that：As follows in (a)~(c) at least one of：

(a) shampoo contains the surfactant of following weight percentage：Laureth sodium sulfovinate or laruyl alcohol are poly- Ether sulfuric ester ammonium 13~18%, laruyl alcohol sodium sulfovinate or bay alcohol sulfuric ester ammonium 4~8%, Cocoamidopropyl betaine 1~ 3%th, tallow fatty acid sodium 1~3%, coconut oleoyl amine DEA0.5~1.5%, coconut oleoyl amine MEA 0.5~2.5%；

(b) shampoo contains the hair conditioner of following weight percentage：Behenyl base trimethyl ammonium chloride or hard ester group three It is ammonio methacrylate 0.1~0.5%, guar hydroxypropyltrimonium chloride 0.1~0.6%, polyquaternium -7 1~5%, poly- Quaternary ammonium salt -10 0.05~0.3%, ring five dimethyl silicone polymer, cyclomethicone or dimethyl silicone polymer 0.5 ~2.5%, panthenol 0.1~1%, aminoethylaminopropyl dimethyl silicone polymer or ammonia end dimethyl silicone polymer 0.5~ 2.5%th, hydrolysis silk 0.5~1.5%, allantoin 0.1~0.5%, Etidronic Acid 0.05~0.15%, EDETATE SODIUM 0.05 ~0.15%, phytosterol Queensland nut oleate 0.2~0.8%, C12-13 alcohol lactate 0.2~0.8%, cocoyl glucose Glycosides 0.2~2%, silk glue protein 0.2~1.2%, dipentaerythritol pentaerythritol tetraisostearate 0.2~0.8%, glyceryl oleate 0.2~1.2%, Anjidew NL50 or glycerine 1~5%；