CN102429954B - Processing method of leonurus - Google Patents
Processing method of leonurus Download PDFInfo
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- CN102429954B CN102429954B CN2011104107413A CN201110410741A CN102429954B CN 102429954 B CN102429954 B CN 102429954B CN 2011104107413 A CN2011104107413 A CN 2011104107413A CN 201110410741 A CN201110410741 A CN 201110410741A CN 102429954 B CN102429954 B CN 102429954B
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- Prior art keywords
- leonurus
- yellow wine
- herba leonuri
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- temperature
- Prior art date
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- 241000207925 Leonurus Species 0.000 title abstract 11
- 238000003672 processing method Methods 0.000 title abstract 3
- 238000001035 drying Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 11
- 230000004087 circulation Effects 0.000 claims description 6
- 238000010025 steaming Methods 0.000 claims description 6
- 238000013461 design Methods 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 3
- 208000002193 Pain Diseases 0.000 abstract description 2
- 238000002791 soaking Methods 0.000 abstract 2
- 238000010411 cooking Methods 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 4
- 229960000583 acetic acid Drugs 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 208000024756 faint Diseases 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a processing method of leonurus. The processing method comprises the following steps of: firstly taking the leonurus, cutting into sections, adding yellow wine with the weight being 30% of that of the leonurus, putting the mixture into a sealed container, soaking for 1 hour, draining, taking remaining yellow wine for spare use, then putting the soaked leonurus in a high-pressure cooker for cooking, setting the temperature to be 120 DEG C, the time to be 2 hours and the pressure to be 0.2MPa, taking out the leonurus, drying in a hot-air circulating oven for 5 hours at the temperature of 60 DEG C, taking out the leonurus after drying, adding the remaining yellow wine in the soaking step, putting the leonurus and the yellow wine in a sealed container for stuffily moistening till the yellow wine is completely absorbed, then taking the leonurus stuffily moistened by the completely-absorbed yellow wine, drying in the hot-air circulating oven for 5 hours at the temperature of 60 DEG C, drying and obtaining the leonurus. The obtained processed leonurus product has a better pain-relieving effect.
Description
Technical field
The present invention relates to a kind of concocting method of Herba Leonuri, belong to medical technical field.
Background technology
Herba Leonuri is the herb of labiate Herba Leonuri.1 year or biennial herb, summer-flowering.Be born in hill wasteland, ridge, meadow etc.Whole nation most area all has distribution.Pluck when the colored not standard-sized sheet of riotous growth in summer.Edible effect: acrid in the mouth is bitter, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.The treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, the carbuncle skin infection at hematuria.Wine Herba Leonuri concocting method is: get the Herba Leonuri section, spray quantitative yellow wine and mix thoroughly, slightly moistening, after wine is exhausted, put in the parch container, fries to little with slow fire and do, and takes out, and cools (100 jin of every Herba Leonuris are with 15 jin of yellow wine).Analgesia is generally used wine product, finds that in clinical use its curative effect is unstable, is unfavorable for Herba Leonuri application and development in pharmaceuticals industry.
Summary of the invention
In view of the deficiencies in the prior art, the object of the present invention is to provide a kind of concocting method of Herba Leonuri.
The object of the present invention is achieved like this: a kind of concocting method of Herba Leonuri, concoct step as follows:
A. get Herba Leonuri, add the yellow wine of Herba Leonuri weight 30%, put in hermetic container and soaked 1 hour, drain, unnecessary yellow wine is standby;
The Herba Leonuri that b. will soak is placed on steaming and decocting in pressure cooker, and design temperature is 120 ℃, and the time is 2 hours, and pressure is 0.2MPa;
C. take out the Herba Leonuri of High Temperature High Pressure steaming and decocting, dry in heated-air circulation oven, temperature is 60 ℃, and the time is 5 hours, oven dry;
D. the Herba Leonuri after drying adds unnecessary yellow wine in a step immersion process, puts moistening in hermetic container, till being exhausted by medical material to yellow wine;
E. get the Herba Leonuri that is exhausted by the yellow wine moistening, dry in heated-air circulation oven, temperature is 60 ℃, and the time is 5 hours, and oven dry namely gets the Herba Leonuri processed product.
Prior art is compared, and the Herba Leonuri analgesic effect that the present invention makes is better, is conducive to large-scale production and application, compared with prior art has outstanding substantive distinguishing features and significant progressive.
The specific embodiment
Below form by test example foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of Herba Leonuri processed product:
A. get Herba Leonuri 100g, add the 30g yellow wine, put in hermetic container and soaked 1 hour, drain, unnecessary yellow wine is standby;
The Herba Leonuri that b. will soak is placed on steaming and decocting in pressure cooker, and design temperature is 120 ℃, and the time is 2 hours, and pressure is 0.2MPa;
C. take out the Herba Leonuri of High Temperature High Pressure steaming and decocting, dry in heated-air circulation oven, temperature is 60 ℃, and the time is 5 hours, oven dry;
D. the Herba Leonuri after drying adds unnecessary yellow wine in a step immersion process, puts moistening in hermetic container, till being exhausted by medical material to yellow wine;
E. get the Herba Leonuri that is exhausted by the yellow wine moistening, dry in heated-air circulation oven, temperature is 60 ℃, and the time is 5 hours, and oven dry namely gets the Herba Leonuri processed product.
Embodiment 2: different Herba Leonuri processed product analgesic activity researchs
1 materials and methods
1.1 animal cleaning level ICR mice, body weight 18-22g, male and female half and half are provided by Yangzhou University's medical college Experimental Animal Center, licence: SCXK (Soviet Union) 2004-0006.
1.2 reagent: yellow wine (Guyuelongshan Shaoxing Wine Co Ltd, Zhejiang, 20090303)
1.3 medicine
The common processed product of Herba Leonuri: get Herba Leonuri 100g, add the 15g yellow wine, mix thoroughly, slightly moistening, after yellow wine is exhausted, fry to little and do, and dries in the air cool, gets the common processed product of Herba Leonuri.
Herba Leonuri processed product of the present invention: press above-described embodiment 1 and prepare and get.
1.4 method
30 healthy ICR mices are divided into 3 groups at random, and 10 every group, male and female half and half are divided into model group, the common processed product of Herba Leonuri, Herba Leonuri processed product group of the present invention.Every afternoon model group gavage pure water 10ml/kg, the common processed product of Herba Leonuri, Herba Leonuri processed product group dosage of the present invention are 8.6g crude drug/kg, gavage volume 0.1ml/10g, continuous 10 days.After the last administration, each was organized lumbar injection 0.5% glacial acetic acid 0.1ml/ of morning every day, observed immediately the writhing number of times of mice in 10 minutes after injection.See Table 1.
Analgesia percentage rate (%)=(model group writhing response number of times one administration group writhing response number of times)/model group writhing response number of times x 100%
The effect (x ± s, n=10) of table 1 the present invention to mice acetic acid induced pain writhing
Compare * * P＜0.01 with the common processed product group of Herba Leonuri
In table 1, result shows, the acetic acid 0.lrnl/ of mouse peritoneal injection 0.5% only can cause mouse peritoneal pain, writhing response occurs.After administration, Herba Leonuri processed product analgesic activity of the present invention is significantly better than the common processed product of Herba Leonuri.
Claims (1)
1. the concocting method of a Herba Leonuri is characterized in that concocting step as follows:
A. get Herba Leonuri, cutting adds the yellow wine of Herba Leonuri weight 30%, puts in hermetic container and soaks 1 hour, drains, and unnecessary yellow wine is standby;
The Herba Leonuri that b. will soak is placed on steaming and decocting in pressure cooker, and design temperature is 120 ℃, and the time is 2 hours, and pressure is 0.2MPa;
C. take out the Herba Leonuri of High Temperature High Pressure steaming and decocting, dry in heated-air circulation oven, temperature is 60 ℃, and the time is 5 hours, oven dry;
D. the Herba Leonuri after drying adds unnecessary yellow wine in a step immersion process, puts moistening in hermetic container, till being exhausted by medical material to yellow wine;
E. get the Herba Leonuri that is exhausted by the yellow wine moistening, dry in heated-air circulation oven, temperature is 60 ℃, and the time is 5 hours, and oven dry namely gets the Herba Leonuri processed product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104107413A CN102429954B (en) | 2011-12-11 | 2011-12-11 | Processing method of leonurus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104107413A CN102429954B (en) | 2011-12-11 | 2011-12-11 | Processing method of leonurus |
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| Publication Number | Publication Date |
|---|---|
| CN102429954A CN102429954A (en) | 2012-05-02 |
| CN102429954B true CN102429954B (en) | 2013-06-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104107413A Active CN102429954B (en) | 2011-12-11 | 2011-12-11 | Processing method of leonurus |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230434B (en) * | 2013-04-18 | 2015-04-15 | 杭州求本植物科技有限公司 | Manufacturing process of leonurus |
| CN103285075A (en) * | 2013-06-21 | 2013-09-11 | 康美药业股份有限公司 | Processed common motherwort herb, processing method and applications thereof |
| CN105982957A (en) * | 2016-01-25 | 2016-10-05 | 安徽亿源药业股份有限公司 | Motherwort processing method |
| CN107260798A (en) * | 2017-05-04 | 2017-10-20 | 广州市药材公司中药饮片厂 | A kind of concocting method of Chinese medicine motherwort |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541676A (en) * | 2003-11-06 | 2004-11-03 | 李德峰 | Health care medicine for enriching blood in puerperium and its preparation and uses |
| CN102102060A (en) * | 2009-12-18 | 2011-06-22 | 陆卫东 | Production process for red-rooted salvia root yellow wine |
-
2011
- 2011-12-11 CN CN2011104107413A patent/CN102429954B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541676A (en) * | 2003-11-06 | 2004-11-03 | 李德峰 | Health care medicine for enriching blood in puerperium and its preparation and uses |
| CN102102060A (en) * | 2009-12-18 | 2011-06-22 | 陆卫东 | Production process for red-rooted salvia root yellow wine |
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| Publication number | Publication date |
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| CN102429954A (en) | 2012-05-02 |
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Address after: 432900 East extension of No. three East Road, Xiaochang Economic Development Zone, Xiaogan, Hubei Patentee after: Hubei Nuo Kete medicine company limited-liability company Address before: 432900 East extension of No. three East Road, Xiaochang Economic Development Zone, Xiaogan, Hubei Patentee before: Hubei Nuokete Pharmaceutical Co., Ltd. |