CN102727834B - Traditional Chinese medicine composition for treating migraine, and preparation method and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition, which achieves the purpose of treating migraine by promoting blood circulation, removing blood stasis, promoting qi and relieving pain. In order to achieve this purpose, the following technical scheme is adopted: the active ingredients contained in it are prepared by the following ratio of raw materials by weight: Formation: 10-30 parts of Curcuma, 5-15 parts of Octopus Golden Dragon, 10-20 parts of Zhaifeng Umbrella, 5-15 parts of Corydalis Corydalis, and the corresponding preparation method is used to prepare Babu ointment. The traditional Chinese medicine composition has therapeutic Efficacy for migraines.

Description

A kind of traditional Chinese medicine composition for treating migraine and its preparation method and application

technical field

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating migraine, a preparation method and application thereof.

Background technique

Migraine is a kind of throbbing headache that recurs, and it belongs to the "big family" among many types of headaches. Before the onset, there are often auras such as flashes of light, blurred vision, and numbness of the limbs. From a few minutes to an hour, there will be throbbing pain on one side of the head, which will gradually intensify until nausea and vomiting occur. The improvement is headache relief in a quiet, dark environment or after sleep. It may be accompanied by neurological and mental dysfunction before or during the onset of headache. So far, drug treatment is still the best way to control the disease. Western medicine uses vasoconstrictors, hormones, prostaglandin inhibitors, etc., but these drugs have different degrees of toxic and side effects. Traditional Chinese medicine preparations such as Xiongju Shangqing Pills, Zhennaoning, Yanhu Zhitong Tablets, Compound Yangjiao Granules, Chuan Shao Tea Tiao Bubbles, Taiji Tongtian Liquid, and Zhengtian Pills are all oral medicines with slow onset of action. A kind of external medicine for the treatment of migraine is urgently needed in the market at present.

Contents of the invention

Purpose of the invention: in order to solve the above problems, the purpose of the present invention is to provide a kind of Chinese medicine preparation for the treatment of migraine.

Another object of the present invention is to provide a preparation method and application of a traditional Chinese medicine preparation for treating migraine.

Technical scheme: the purpose of the present invention is achieved by the following scheme:

A traditional Chinese medicine composition for treating migraine, the active ingredient contained in it is prepared by extracting and proportioning the following raw materials by weight: 10-30 parts of curcuma, 5-15 parts of octopus, and 10-20 parts of chasing wind umbrella , Corydalis 5-15 copies.

The above-mentioned traditional Chinese medicine composition for treating migraine, the active ingredient contained in it is prepared by extracting the following raw materials by weight: 20 parts of curcuma, 10 parts of octopus, 15 parts of chasing wind umbrella, and 10 parts of corydalis.

In the above-mentioned traditional Chinese medicine composition for treating migraine, the crude drug is extracted and then added with a matrix to make a cataplasm plaster.

The above-mentioned traditional Chinese medicine composition for treating migraine, the base is 3-6 parts of sodium polyacrylate, 1-3 parts of polyvinylpyrrolidone, 1-2 parts of polyvinyl alcohol, 6-10 parts of gelatin, 2 parts of carboxymethylcellulose sodium -3 parts, glycerin 2-3 parts, kaolin 3-5 parts, calcium carbonate 2-4 parts, azone 2-4 parts, propylene glycol 2-4 parts, water 6-10 parts and ethylparaben 0.02- 0.04 parts.

The method for the above-mentioned Chinese medicine composition for the treatment of migraine, the preparation steps are:

a. Combine curcuma, octopus, chasing wind umbrella, and corydalis, crush them, use ethanol as solvent, and percolate after 5-20 hours of wetting, collect the percolation liquid, recover ethanol under reduced pressure and concentrate it to 50°C. thick paste with a density of 1.28-1.32;

b. Take sodium polyacrylate, kaolin, calcium carbonate and add glycerin and stir evenly to obtain suspension I;

c. Take sodium carboxymethyl cellulose and add water, heat, stir from time to time until uniform, slowly add polyvinylpyrrolidone and polyvinyl alcohol, and stir while adding until uniform, to obtain mixture II;

d. Add water to the gelatin, heat, stir until it becomes uniform and translucent, combine with the mixture II, add the thick paste obtained in the above step a, stir evenly, then add the suspension I, azone, propylene glycol, and paraben in sequence Ethyl ester, stirred evenly, coated by a coating machine while hot, cut and packaged.

In the preparation method of the above-mentioned traditional Chinese medicine composition for treating migraine, the concentration of ethanol in step a is 50%, the amount added during percolation is 5 times the weight of the medicinal material, and the ethanol is recovered under reduced pressure and concentrated to 50 DEG C with a relative density of 1.3. paste.

It is found through clinical experiment research that the traditional Chinese medicine composition of the present invention has a good effect on treating migraine. Therefore, the present invention also provides the use of the above-mentioned pharmaceutical composition, that is, the application of the above-mentioned traditional Chinese medicine composition for treating migraine in the preparation of medicine for treating migraine.

Beneficial effect:

1. From the perspective of traditional Chinese medicine theory, in this prescription, Curcuma breaks blood and promotes qi, eliminates stagnation and relieves pain, and Octopus Golden Dragon removes blood stasis to stop bleeding, promotes blood circulation and relieves pain. Both Curcuma and Octopus Golden Dragon are the monarch drug, promoting blood circulation and removing blood stasis, chasing wind umbrella and dispelling wind. Collaterals, promoting blood circulation and relieving pain, Corydalis activating blood circulation, promoting qi, and relieving pain, Zhuifeng Umbrella and Corydalis Corydalis are a total of ministerial medicines, promoting qi and relieving pain, all medicines are combined, and play the effects of promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and are used to treat migraine. 2. The prescription design of the present invention is reasonable and the compatibility is strict. 3. The composition of the present invention is Chinese herbal medicine, has no toxic and side effects, and is cheap.

Detailed ways

Below by embodiment form, above-mentioned content of the present invention is described in further detail again, but this should not be interpreted as the scope of the above-mentioned theme of the present invention being limited to following examples, all technologies realized based on the above-mentioned content of the present invention all belong to this invention the scope of the invention.

1, in conjunction with specific embodiment, the present invention is further described as follows:

The weight ratio listed in the table below takes the required bulk drug of the present invention, unit: part

Curcuma Octopus Golden Dragon Chasing Umbrella Corydalis 1 10 15 10 15 2 20 10 15 10 3 30 5 20 5

The weight ratio listed in the table below takes by weighing the required substrate raw materials of the present invention, unit: part

The chasing wind umbrella in the raw material medicine of the present invention is the whole herb of Lysimachiatrientaloides Hemsl, a perennial herb of the genus Lysimachiatrientaloides Hemsl of the genus Primulaceae, and Ardisia crispa (Thunb.) DC., the roots and leaves are used as medicine. Summer and autumn collection. , and the rest are selected from Chinese Pharmacopoeia varieties.

2, preparation embodiment

The ratio of raw materials in the above table is an example, including the following steps:

Example 1:

a. Take 10g of Curcuma, 15g of Octopus, 10g of Zhaifeng Umbrella, and 15g of Corydalis Corydalis and combine them, crush them, use 50% ethanol as solvent, and percolate after wetting for 5 hours, add 50% ethanol of 5 times the weight of the medicinal materials for percolation, Collect the percolate, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.28 at 50°C;

b. Take 3g of sodium polyacrylate, 3g of kaolin, 4g of calcium carbonate, add 3g of glycerin and stir evenly to obtain suspension I;

c. Take 2 g of sodium carboxymethyl cellulose and add 3 g of water, heat, stir from time to time until uniform, slowly add 3 g of polyvinylpyrrolidone and 1 g of polyvinyl alcohol, and stir while adding until uniform, to obtain mixture II;

d. Add 10g of gelatin to 3g of water, heat, stir until uniform translucency, combine with mixture II, add the thick paste obtained in the above step a, stir evenly, then add suspension I, azone 2g, propylene glycol 4g in turn 1. Ethylparaben 0.04g, stir evenly, apply by coating machine while hot, cut and pack.

Example 2:

a. Take 20g of Curcuma, 10g of Octopus, 15g of Chasing Wind Umbrella, and 10g of Corydalis Corydalis and combine them, crush them, use 50% ethanol as a solvent, and percolate after 15 hours of wetting, add 50% ethanol of 5 times the weight of the medicinal materials for percolation, Collect the percolate, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30 at 50°C;

b. Take 5g of sodium polyacrylate, 4g of kaolin, 3g of calcium carbonate, add 2.5g of glycerin and stir evenly to obtain suspension I;

c. Take 2.5 g of sodium carboxymethyl cellulose and add 4 g of water, heat, stir from time to time until uniform, slowly add 2 g of polyvinylpyrrolidone and 1.5 g of polyvinyl alcohol, and stir while adding until uniform, to obtain mixture II;

d. Add 8g of gelatin to 4g of water, heat, stir until uniform translucency, combine with mixture II, add the thick paste obtained in the above step a, stir evenly, then add suspension I, azone 3g, propylene glycol 3g in turn 1. Ethylparaben 0.03g, stir evenly, apply by coating machine while hot, cut and pack.

Example 3:

a. Take 30g of Curcuma, 5g of Octopus, 20g of Chasing Wind Umbrella, and 5g of Corydalis Corydalis and combine them, crush them, use 50% ethanol as a solvent, and percolate after 15 hours of wetting, add 50% ethanol of 5 times the weight of the medicinal materials for percolation, Collect the percolate, recover ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30 at 50°C;

b. Take 6 g of sodium polyacrylate, 5 g of kaolin, 2 g of calcium carbonate, add 2 g of glycerin and stir evenly to obtain suspension I;

c. Take 3 g of sodium carboxymethyl cellulose and add 5 g of water, heat, stir from time to time until uniform, slowly add 1 g of polyvinylpyrrolidone and 2 g of polyvinyl alcohol, and stir while adding until uniform, to obtain mixture II;

d. Add 6 g of gelatin to 5 g of water, heat, stir until it becomes uniform and translucent, combine with mixture II, add the thick paste obtained in the above step a, stir evenly, then add suspension I, azone 4 g, and propylene glycol 2 g in sequence 1. Ethylparaben 0.02g, stir evenly, apply by coating machine while hot, cut and pack.

3. Clinical Observation and Typical Cases: Clinical Curative Effect Observation Experiment of Chinese Medicine Composition of the Present Invention in Treating Migraine Patients

One, the general data of experimental object: adopt Chinese medicine composition of the present invention to treat altogether 30 cases, wherein 18 cases are male, 12 cases are female, the oldest person is 52 years old, the youngest person is 35 years old, the average age is 44.5 years old, and the course of disease is 5 months old. Between months and 10 years, with an average of 2 and a half years, the number of episodes per month is 2-4 times, and the duration of each episode is 1-4 days. The average number of episodes is 3 times/month, and the duration is 3 days. All patients with migraine were outpatients. No abnormalities were found in brain CT examinations in all cases, and headaches caused by other causes were excluded according to medical history, physical examination and related examinations. There were no hypertension, epilepsy and other diseases. Month did not take other medicines for the treatment of headache.

2. Therapeutic method: usage and dosage: adopt the babu ointment prepared by the embodiment of the present invention 2, the steps are a. Get 20g of curcuma, 10g of octopus, 15g of chasing wind umbrella, and 10g of Corydalis 10g medicinal materials, pulverize, and use 50% ethanol As a solvent, percolate after wetting for 15 hours, add 50% ethanol of 5 times the weight of medicinal materials for percolation, collect the percolation liquid, recycle ethanol under reduced pressure and concentrate to a thick paste with a relative density of 1.30 when it is concentrated to 50°C; b. Add 5g of sodium acrylate, 4g of kaolin, 3g of calcium carbonate, add 2.5g of glycerin and stir evenly to obtain suspension I; c. Take 2.5g of sodium carboxymethyl cellulose and add 4g of water, heat, stir from time to time until uniform, slowly add poly Add 2g of vinylpyrrolidone and 1.5g of polyvinyl alcohol, stir until uniform, and obtain mixture II; d. add 8g of gelatin to 4g of water, heat, stir until uniform and translucent, combine with mixture II, and add to the above step a The obtained thick paste was stirred evenly, and then the suspension I, azone 3g, propylene glycol 3g, and ethylparaben 0.03g were added successively, stirred evenly, coated by a coating machine while hot, cut, and packaged to obtain 10 pieces Babu ointment, its usage and dosage are 1 stick each time, 3 times a day, apply on the temples, one month is a course of treatment, a total of 3 courses of treatment.

3. Efficacy Evaluation Criteria

Recovery from illness: the headache disappeared, accompanied by symptoms turning negative, physical and chemical examinations were normal, and there was no outbreak within 6 months. Effective: relieved headache, shortened attack time or prolonged period, accompanied by symptoms or recurrence, normal physical and chemical examination. Ineffective: No obvious changes in headache and accompanying symptoms.

Among the 30 cases treated, after 3 months of treatment, 21 cases were cured, 6 cases were effective, and 3 cases were ineffective. The total effective rate reached 90%. The results show that the traditional Chinese medicine composition of the present invention has extremely significant effect on treating migraine patients.

4. Typical cases

1. Li XX, female, 46 years old, the course of migraine is 1 year, the average number of attacks per month is 2 times, and the duration of each attack is 2 days. Look into: body of the tongue is dark red, fur is thin and white, stringy and tight pulse. Use cataplasm ointment of the present invention, use continuously 1 month, all diseases disappear and recover from illness, follow up a case by regular visits to and do not recur again in half a year.

2. Wang XX, male 42 years old, the course of migraine is 3 years, the average number of attacks per month is 3 times, and the duration of each attack is 3 days. Look into: body of the tongue is dark red, fur is thin and white, deep and slow pulse. Use cataplasm ointment of the present invention, use continuously for 2 months, all diseases disappear and recover from illness, follow up a case by regular visits to and do not recur again half a year.

Claims (4)

1. A traditional Chinese medicine composition for the treatment of migraine, characterized in that the active ingredients it contains are prepared by extracting the following proportions of raw materials by weight: 10-30 parts of curcuma, 5-15 parts of octopus, chasing 10-20 parts of Umbrella, 5-15 parts of Corydalis Corydalis. The Octopus is Ardisia crispa (Thunb.) DC., a plant of the genus Ardisia crispa (Thunb.) DC. The root and leaves are used as medicine, and the raw material drug is extracted Afterwards, add matrix to make cataplasm paste, said matrix is 3-6 parts of sodium polyacrylate, 1-3 parts of polyvinylpyrrolidone, 1-2 parts of polyvinyl alcohol, 6-10 parts of gelatin, sodium carboxymethylcellulose 2 -3 parts, glycerin 2-3 parts, kaolin 3-5 parts, calcium carbonate 2-4 parts, azone 2-4 parts, propylene glycol 2-4 parts, water 6-10 parts and ethylparaben 0.02- 0.04 parts, the preparation steps are: a. Combine curcuma, octopus, chasing wind umbrella, and corydalis, crush them, use ethanol as solvent, and percolate after 5-20 hours of wetting, collect the percolation liquid, recover ethanol under reduced pressure and concentrate it to 50°C. thick paste with a density of 1.28-1.32; b. Take sodium polyacrylate, kaolin, calcium carbonate and add glycerin and stir evenly to obtain suspension I; c. Take sodium carboxymethyl cellulose and add water, heat, stir from time to time until uniform, slowly add polyvinylpyrrolidone and polyvinyl alcohol, and stir while adding until uniform, to obtain mixture II; d. Add water to the gelatin, heat, stir until it becomes uniform and translucent, combine with the mixture II, add the thick paste obtained in the above step a, stir evenly, then add the suspension I, azone, propylene glycol, and paraben in sequence Ethyl ester, stirred evenly, coated by a coating machine while hot, cut and packaged. the 2. The traditional Chinese medicine composition for treating migraine as claimed in claim 1, wherein the active ingredient contained in it is prepared by extracting the following proportions of raw materials by weight: 20 parts of curcuma, 10 parts of Octopus, 15 copies of wind umbrella and 10 copies of Yanhusuo. the 3. the Chinese medicine composition for the treatment of migraine as claimed in claim 1, is characterized in that, ethanol concentration is 50% in the preparation step a, and the addition amount is 5 times of medical material weight during percolation, and decompression reclaims ethanol and concentrates to Thick paste with a relative density of 1.3 at 50°C. the 4. the application of the Chinese medicine composition for the treatment of migraine as claimed in claim 1 in the preparation treatment migraine medicine. the