CN102384906B - Hemoglobin detection plate and its preparation method and application - Google Patents
Hemoglobin detection plate and its preparation method and application Download PDFInfo
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- CN102384906B CN102384906B CN201110216983.9A CN201110216983A CN102384906B CN 102384906 B CN102384906 B CN 102384906B CN 201110216983 A CN201110216983 A CN 201110216983A CN 102384906 B CN102384906 B CN 102384906B
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- 238000001514 detection method Methods 0.000 title claims abstract description 55
- 108010054147 Hemoglobins Proteins 0.000 title claims abstract description 40
- 102000001554 Hemoglobins Human genes 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000006243 chemical reaction Methods 0.000 claims abstract description 48
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 46
- 239000007790 solid phase Substances 0.000 claims abstract description 33
- 238000007781 pre-processing Methods 0.000 claims abstract description 21
- 239000000969 carrier Substances 0.000 claims description 43
- 239000000758 substrate Substances 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 11
- 108010061951 Methemoglobin Proteins 0.000 claims description 8
- 238000005520 cutting process Methods 0.000 claims description 8
- 230000008878 coupling Effects 0.000 claims description 6
- 238000010168 coupling process Methods 0.000 claims description 6
- 238000005859 coupling reaction Methods 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001540 azides Chemical class 0.000 claims description 4
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 7
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 abstract description 2
- 230000004044 response Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 13
- 238000003746 solid phase reaction Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 8
- 239000004033 plastic Substances 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229940123973 Oxygen scavenger Drugs 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
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- 239000012528 membrane Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 229910002092 carbon dioxide Chemical group 0.000 description 1
- 239000001569 carbon dioxide Chemical group 0.000 description 1
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- 229920002521 macromolecule Polymers 0.000 description 1
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- 229920006267 polyester film Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007430 reference method Methods 0.000 description 1
- 238000011309 routine diagnosis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of hemoglobin detection plate and its preparation method and application, it is characterized in that comprising sample preprocessing district and solid-phase reagent reaction zone, wherein in several sample preprocessing devices in sample preprocessing district, hemocytolysis in whole blood is broken, stripping haemoglobin is also sent to the solid-phase reagent reaction zone of the reaction reagent that is cured in advance, complete chemical reaction, obtain testing result; Also disclosed is the preparation method of this hemoglobin detection plate.The present invention can one-time detection many human hemoglobins concentration, is swift in response, accuracy and precision high; Reproducible, meet the demand of extensive quick test on hospital and mobile blood-collecting carriage completely.
Description
Technical field
Detect the device of many human hemoglobins while of the present invention relates to a kind of fast, belong to technical field of medical equipment, particularly a kind of hemoglobin detection plate and its preparation method and application.
Background technology
Haemoglobin is a kind of protein being responsible for delivery oxygen in human body, as the important substance completing oxygen and carbon dioxide exchange in blood, is the pacing items of the activity of sustaining life.It is the most important index diagnosing severity of anemia clinically that haemoglobin detects, and is also the hemopathic important indicators of auxiliary diagnosis other types simultaneously.At present, detect the principle of haemoglobin clinically generally based on cyanmethemoglobin method (HiCN method), azide methemoglobin method (HiN3 method) or lauryl sodium sulfate haemoglobin method (SLS-Hb method), wherein cyanmethemoglobin method is that ICSH recommends reference method.The blood analyser designed based on above-mentioned principle and matched reagent apply wider haemoglobin detection method clinically.
Dry chemical detection technique is the Novel test technology that development in recent years is got up.Dry chemical detection technique by clinical labororatory is accepted, becomes the new force of biochemistry test routine and emergency treatment testing with the performance of its uniqueness.Compared with classic method, have simple to operate, speed fast, pollute less, result stablizes the plurality of advantages such as accurate.The mode that dry chemical detects, normally by participating in each chemical reagent wiring solution-forming in proportion of reaction, being added on solid phase reaction carrier, can be used for clinical detection after drying.In testing process, the chemical agent dissolves speed applied in dry chemical detection method is fast, local concentration is high, reaction velocity is fast, meanwhile, can ensure that some reagent maintain a long-term stability under solid dry material state.
At present, dry chemical Fast Detection Technique, still emerging technology is belonged in clinical detection field, apply still very not extensive at home and abroad, its main cause, except technically there is certain difficulty, its detection mode can only realize single individual event visual inspection and survey, although detection architecture is more stable, but detection efficiency is on the low side, this is also hinder dry chemical detection technique to further develop and comprehensively universal major reason.
Summary of the invention
The invention provides a kind of hemoglobin detection plate and its preparation method and application, solve the problem that multisample detects hemoglobin concentration simultaneously, testing result is stable, detection efficiency is high, elegant in shape, facilitates easy-to-use.
The present invention is realized by following technical scheme:
A kind of hemoglobin detection plate, comprise sample preprocessing device and solid-phase reagent reaction carriers, described sample preprocessing device is several, be opened on bearing substrate, the sample carriers of its inner fixing point sample chemical reagent, described solid-phase reagent reaction carriers is fixed on carrying cover plate, and described bearing substrate and carrying cover plate are fixedly mounted by coupling arrangement.
Described sample preprocessing device is slot type container, and body is embedded on described bearing substrate.
Described sample carriers is a kind of sample carriers of thieving paper material.
Described bearing substrate is made up of a kind of material in tygon, Polyvinylchloride, polypropylene and organic glass.Except above-mentioned preferred material, the hydrophobic polymeric material that other hardness are high also may be used for the preparation of bearing substrate.
Above-mentioned sample preprocessing device installs fixing sample carriers additional with it and constitutes sample preprocessing district, after the whole blood of collection is inserted sample preprocessing device, with the sample carriers generation effect having cured molten born of the same parents' agent, hemocytolysis is broken, stripping haemoglobin.
Described carrying cover plate is arranged the corresponding window of some and described sample preprocessing setting position.
Described solid-phase reagent reaction carriers is a kind of polymeric membrane, needs the commercially available macromolecule member material can selecting different materials, as the nitrocellulose filter, polyester film etc. of different pore size according to test item.
Covering solid-phase reagent reaction carriers pasted by each window described.The membrane structure of such solid-phase reagent reaction carriers is separated from each other, independent mutually, can be used for the detection of a person-portion or many person-portions blood-hemoglobin.
Described coupling arrangement is a cushion, and cushion has certain thickness and elasticity, and there is bonding agent on both sides, and carrier substrate and carrier cover plate are carried out non-tight connection.
Carrying cover plate and solid-phase reagent reaction carriers constitute solid-phase reagent reaction zone, are fixed on needing the various chemical reaction reagents detected in advance on solid-phase reagent reaction carriers.
Sample carriers and solid-phase reagent reaction carriers contact under particular instrument controls, solid-phase reagent reaction zone is sent at the haemoglobin of sample preprocessing district stripping, react with the chemical reagent on solid-phase reagent reaction carriers in solid-phase reagent reaction zone, through dry sheet type fast detecting instrument, by light source and optical sensor, the color detected on solid-phase reagent reaction carriers film changes and then calculates the concentration of measured object.In testing process, detector gathers photosignal, analyze and data processing.On hemoglobin detection plate, chemical reaction process automatically carries out under detector thermostatic control, have that reaction velocity is fast, reproducible, accuracy, precision advantages of higher.
The present invention also provides the preparation method of this hemoglobin detection plate, is to be realized by following step:
(1) cutting is fixing: according to the specification processing and fabricating bearing substrate of working in coordination and carrying cover plate, bearing substrate is offered sample preprocessing device groove, window offered by carrying cover plate.Solid-phase reagent reaction carriers, the sample carriers of cutting correspondingly-sized, be fixed on sample preprocessing device by sample carriers, solid-phase reagent reaction carriers employing 300 ~ 500 DEG C of heat seal modes pasted on the window covering carrying cover plate;
(2) point sample: will detect the reaction reagent required for hemoglobin concentration, quantitative point sample is on solid-phase reagent reaction carriers and sample carriers;
(3) bake drying: dry 30 ~ 120min in 30 ~ 60 DEG C of baking ovens by the solid-phase reagent reaction carriers after point sample and sample carriers;
(4) assemble: carrying cover plate and bearing substrate are carried out non-tight connection by coupling arrangement.
Wherein on solid-phase reagent reaction carriers point sample be solidified with promote haemoglobin change into methemoglobin nitrite, methemoglobin can be made to be converted into the sodium azide of azide methemoglobin, and adopt inorganic acid for adjusting pH 6 ~ 7.
Beneficial effect of the present invention is: hemoglobin detection plate is applied to the hemoglobin concentration of Quantitative detection people whole blood sample clinically.Be swift in response because product of the present invention has, accuracy, the feature such as precision is high, multisample detects simultaneously, therefore the multiple requirements such as routine diagnosis, emergency treatment, the examination of blood source in practical application, can be met.
The present invention relates to product hemoglobin detection plate design and develop and technology path science, rationally, automaticity is high, stable performance, multiple functional, elegant in shape, facilitates easy-to-use.Testing result accuracy is high, reproducible, and detection speed is fast, can meet the needs of extensive quick test on situation of all-level hospitals and mobile blood-collecting carriage completely.
Accompanying drawing explanation
Fig. 1 is the structural representation of single part hemoglobin detection plate
Fig. 2 is the structural representation of four person-portion hemoglobin detection plates
Fig. 3 is four person-portion hemoglobin detection plate carrying cover plate and the window schematic diagram on it
Embodiment
Below in conjunction with drawings and Examples, the present invention will be further described.
Embodiment 1
Single part hemoglobin detection plate
The detection method of hemoglobin detection plate realizes the quantitative measurement of haemoglobin based on the method that azide methemoglobin detects, this method testing result is stable, degree of accuracy is high, is one of internationally recognized haemoglobin detection method.
Hemoglobin detection plate comprises sample preprocessing district and solid-phase reagent reaction zone.Wherein whole blood is in sample preprocessing district through molten born of the same parents' agent cracking haemocyte stripping haemoglobin, is sent to solid-phase reagent reaction zone, the solid phase reaction carrier film of solid-phase reagent reaction zone solidifies reaction reagent in advance after diffusion.Reaction reagent reacts with haemoglobin wherein, finally produce the change of obvious color on a carrier film, according to the difference of measured object Hb concentration, present color change in various degree, reflectance photometry method colorimetric principle is utilized quantitatively to detect by dry sheet type fast detecting instrument again, by going out Hb concentration in sample to the color change detection of reaction end.Chemical equation is as follows:
Hb+NaNO
2→Hi
Hi+NaN
3→HiN
3
Main composition: every sheet hemoglobin detection plate solid-phase reagent reaction carriers and sample carriers contain following material:
The preparation of hemoglobin detection plate: (as Fig. 1)
1. cutting is fixing: by solid phase reaction carrier film 1, sample pad 4, loading slot 3 by specification cutting, and the bearing substrate of processing and fabricating dimensional fits and carrying cover plate are hard substrate 5 and plastic strip frame 2 in the present embodiment.Sample pad 4 is installed additional and is fixed on loading slot 3; Solid phase reaction carrier film 1 is covered on plastic strip frame 2 500 DEG C of heat seals.
2. point sample: by detecting agent prescription needed for haemoglobin, preparation reaction working fluid I, quantitative 1.5-2.5 μ l/ sheet point sample is in solid phase reaction carrier film; Reaction working fluid II, quantitative 15-18 μ l/ sheet point sample is in sample pad.
3. dry: by the solid phase reaction carrier film 1 after point sample and sample pad 4 in 40 DEG C of baking ovens dry 90 minutes.
4. assemble: plastic strip frame 2 and hard substrate 5 are fixed together by the upper and lower two-layer binder of cushion 6.Install drying agent, oxygen scavenger additional, be sealed in aluminium foil bag, in 2-8 DEG C of refrigerator store, for subsequent use.
Clinical detection:
Get 15-20 μ l finger tip peripheral blood, be added in the loading slot of hemoglobin detection plate, and be put in by check-out console in matching used dry sheet type fast detecting instrument, in 3 minutes, detector shows result automatically.
Embodiment 2
Four person-portion hemoglobin detection plates
Cleaning Principle is the same.
Main composition
Solid-phase reagent reaction carriers on each window of hemoglobin detection plate and the sample pad of correspondence contain following material:
Every sheet hemoglobin detection plate has 4 windows, and namely reagent total amount is:
The preparation of hemoglobin detection plate: (as Fig. 2)
1. cutting is fixing: by solid phase reaction carrier film 1, sample pad 4, loading slot 3 by specification cutting, and the bearing substrate of processing and fabricating dimensional fits and carrying cover plate are hard substrate 5 and plastic strip frame 2 in the present embodiment.Sample pad 4 is installed in loading slot 3; Solid phase reaction carrier film 1 is covered on plastic strip frame 2 500 DEG C of heat seals.
2. point sample: by detecting agent prescription needed for haemoglobin, preparation reaction working fluid I, quantitative 1.5-2.5 μ l/ sheet point sample is in solid phase reaction carrier film; Reaction working fluid II, quantitative 15-18 μ l/ sheet point sample is in sample pad.
3. dry: by the solid phase reaction carrier film 1 after point sample and sample pad 4 in 40 DEG C of baking ovens dry 120 minutes.
4. assemble: plastic strip frame 2 and hard substrate 5 are fixed together by the upper and lower two-layer binder of cushion 6.Install drying agent, oxygen scavenger additional, be sealed in aluminium foil bag, in 2-8 DEG C of refrigerator store, for subsequent use.
Clinical detection:
Get 15-20 μ l finger tip peripheral blood, be added in the loading slot of hemoglobin detection plate, and be put in by check-out console in matching used dry sheet type fast detecting instrument, in 3 minutes, detector shows result automatically.
As Fig. 3, be four person-portion hemoglobin detection plate carrying cover plate and the window schematic diagram on it, in the above-described embodiments, solid phase reaction carrier film 1 is all be fixedly mounted on the window 7 of plastic strip frame 2.
Claims (8)
1. a hemoglobin detection plate, comprise sample preprocessing device and solid-phase reagent reaction carriers, it is characterized in that described sample preprocessing device is for several, be opened on bearing substrate, the sample carriers of its internal fixtion point sample chemical reagent, described solid-phase reagent reaction carriers is arranged on carrying cover plate, and described bearing substrate and carrying cover plate are fixedly mounted by coupling arrangement; On described solid-phase reagent reaction carriers point sample be solidified with promote haemoglobin change into methemoglobin nitrite, make described methemoglobin be converted into the sodium azide of azide methemoglobin.
2. hemoglobin detection plate as claimed in claim 1, it is characterized in that described sample preprocessing device is slot type container, body is embedded on described bearing substrate.
3. hemoglobin detection plate as claimed in claim 1, is characterized in that described sample carriers is a kind of sample carriers of thieving paper material.
4. hemoglobin detection plate as claimed in claim 1, is characterized in that described bearing substrate is the bearing substrate be made up of a kind of material in tygon, Polyvinylchloride, polypropylene and organic glass.
5. hemoglobin detection plate as claimed in claim 1, is characterized in that described carrying cover plate being arranged the corresponding window of some and described sample preprocessing setting position.
6. hemoglobin detection plate as claimed in claim 1, is characterized in that covering solid-phase reagent reaction carriers pasted by each window described.
7. hemoglobin detection plate as claimed in claim 1, is characterized in that described coupling arrangement is a cushion, carrier substrate and carrier cover plate is carried out non-tight connection.
8. a preparation method for hemoglobin detection plate, it is characterized in that by following step realize:
(1) cutting is fixing: according to the specification processing and fabricating bearing substrate of working in coordination and carrying cover plate, bearing substrate is offered sample preprocessing device groove, window offered by carrying cover plate, solid-phase reagent reaction carriers, the sample carriers of cutting correspondingly-sized, sample carriers is fixed on sample preprocessing device, solid-phase reagent reaction carriers employing 300 ~ 500 DEG C of heat seal modes is pasted on the window covering carrying cover plate;
(2) point sample: will detect the reaction reagent required for hemoglobin concentration, quantitative point sample is on solid-phase reagent reaction carriers and sample carriers;
(3) dry: dry 30 ~ 120min in 30 ~ 60 DEG C of baking ovens by the solid-phase reagent reaction carriers after point sample and sample carriers;
(4) assemble: carrying cover plate and bearing substrate are carried out non-tight connection by coupling arrangement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110216983.9A CN102384906B (en) | 2011-08-01 | 2011-08-01 | Hemoglobin detection plate and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110216983.9A CN102384906B (en) | 2011-08-01 | 2011-08-01 | Hemoglobin detection plate and its preparation method and application |
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| Publication Number | Publication Date |
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| CN102384906A CN102384906A (en) | 2012-03-21 |
| CN102384906B true CN102384906B (en) | 2016-01-20 |
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| CN110736845A (en) * | 2019-10-31 | 2020-01-31 | 深圳福能医疗科技有限公司 | detection device for glycosylated hemoglobin and detection method thereof |
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| CN201255742Y (en) * | 2008-09-17 | 2009-06-10 | 吕炜锋 | Multifunctional dry plate detection board |
| CN202182864U (en) * | 2011-08-01 | 2012-04-04 | 无锡蓝德生物医药有限责任公司 | Hemoglobin detection board |
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2011
- 2011-08-01 CN CN201110216983.9A patent/CN102384906B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6376254B1 (en) * | 1999-03-19 | 2002-04-23 | DRäGER SICHERHEITSTECHNIK GMBH | Biomimetic reagent system and its use |
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