CN102384906A - Hemoglobin test board and preparation method and application thereof - Google Patents
Hemoglobin test board and preparation method and application thereof Download PDFInfo
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- CN102384906A CN102384906A CN2011102169839A CN201110216983A CN102384906A CN 102384906 A CN102384906 A CN 102384906A CN 2011102169839 A CN2011102169839 A CN 2011102169839A CN 201110216983 A CN201110216983 A CN 201110216983A CN 102384906 A CN102384906 A CN 102384906A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000012360 testing method Methods 0.000 title abstract description 15
- 108010054147 Hemoglobins Proteins 0.000 title abstract description 9
- 102000001554 Hemoglobins Human genes 0.000 title abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 47
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 45
- 239000000969 carrier Substances 0.000 claims description 42
- 239000007790 solid phase Substances 0.000 claims description 30
- 239000000758 substrate Substances 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 11
- 230000008878 coupling Effects 0.000 claims description 6
- 238000010168 coupling process Methods 0.000 claims description 6
- 238000005859 coupling reaction Methods 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 5
- 238000005520 cutting process Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 10
- 239000007787 solid Substances 0.000 abstract description 3
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- 238000001514 detection method Methods 0.000 description 22
- 238000000034 method Methods 0.000 description 12
- 238000003746 solid phase reaction Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 8
- 239000004033 plastic Substances 0.000 description 7
- 108010061951 Methemoglobin Proteins 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 150000001540 azides Chemical class 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229940123973 Oxygen scavenger Drugs 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
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- 229910052760 oxygen Inorganic materials 0.000 description 2
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- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a hemoglobin test board and a preparation method and an application thereof. The hemoglobin test board is characterized by comprising a sample pretreatment are and a solid reagent reaction area, wherein complete blood cells are dissolved and broken in a plurality of sample pretreatment devices of the sample pretreatment area so as to dissolve out hemoglobin and to transmit the hemoglobin to the solid reagent reaction area with the reaction reagent being previously solidified so as to complete the chemical reaction and to obtain the test result. The invention also discloses a preparation method of the hemoglobin test board. Due to the adoption of the hemoglobin test board, the hemoglobin density of multiple people can be simultaneously tested at one time, the reaction is rapid, and the accuracy and the precision are high; and the repeatability is good, and the requirement of large-scale quick test in hospitals and mobile blood collecting vehicles can be satisfied.
Description
Technical field
The present invention relates to the device of the many human hemoglobins of a kind of while fast detecting, belong to the Medical Devices technical field, particularly a kind of haemoglobin check-out console.
Background technology
Haemoglobin is a kind of protein of being responsible for delivery oxygen in the human body, as the important substance of accomplishing oxygen and carbon dioxide exchange in the blood, is the pacing items of the activity of earning a bare living.It is the most important index of diagnosing severity of anemia clinically that haemoglobin detects, and also is the hemopathic important indicators of auxiliary diagnosis other types simultaneously.At present; The principle that detects haemoglobin clinically is generally based on cyanmethemoglobin method (HiCN method), azide methemoglobin method (HiN3 method) or lauryl sodium sulfate haemoglobin method (SLS-Hb method), and wherein the cyanmethemoglobin method is that ICSH recommends reference method.The blood analyser and the matched reagent that design based on above-mentioned principle are to use wider haemoglobin detection method clinically.
The dry chemical detection technique is the novel inspection technology that development in recent years is got up.The dry chemical detection technique is accepted by clinical labororatory with its particular performances, becomes the new force of clinical biochemical check routine and emergency treatment testing.Compare with classic method, have simple to operate, speed fast, pollute less, the result stablizes plurality of advantages such as accurate.The mode that dry chemical detects, each chemical reagent that normally will participate in reacting is wiring solution-forming in proportion, is added on the solid phase reaction carrier, after drying, can be used for Clinical detection.In the testing process, the chemical agent dissolves speed of using in the dry chemical detection method is fast, local concentration is high, reaction velocity is fast, simultaneously, can guarantee that some reagent maintain a long-term stability under solid, dry material state.
At present, the dry chemical Fast Detection Technique still belongs to emerging technology in the Clinical detection field; Use still very not extensive at home and abroad; Its main cause can only realize single individual event visual inspection survey, though detection architecture is more stable on its detection mode except the certain difficulty of technical existence; But detection efficiency is on the low side, and this also is to hinder the dry chemical detection technique to further develop and the major reason of comprehensively popularizing.
Summary of the invention
The present invention provides a kind of haemoglobin check-out console, has solved the problem that multisample detects HC simultaneously, and testing result is stable, detection efficiency is high, elegant in shape, convenient easy-to-use.
The present invention realizes through following technical scheme:
A kind of haemoglobin check-out console; Comprise sample pretreatment unit and solid-phase reagent reaction carriers; Said sample pretreatment unit is several, is opened on the bearing substrate, and its internal fixation is the sample carriers of point sample chemical reagent; Said solid-phase reagent reaction carriers is fixed on and carries on the cover plate, and said bearing substrate fixedly mounts through coupling arrangement with the carrying cover plate.
Said sample pretreatment unit is the slot type container, and body is embedded on the said bearing substrate.
Said sample carriers is a kind of sample carriers of thieving paper material.
Said bearing substrate is to be processed by a kind of material in tygon, PVC, polypropylene and the organic glass.Except that above-mentioned preferred material, the hydrophobic polymeric material that other hardness are high also can be used for the preparation of bearing substrate.
Above-mentioned sample pretreatment unit installs fixing sample carriers additional with it has formed the sample pretreating zone; After the whole blood of gathering inserted the sample pretreatment unit; With the sample carriers generation effect that has cured molten born of the same parents' agent, hemocytolysis is broken, the stripping haemoglobin.
The corresponding window in some and said sample pretreatment unit position is set on the said carrying cover plate.
Said solid-phase reagent reaction carriers is a kind of polymeric membrane, can select the commercially available macromolecule member material of different materials according to the test item needs, like the nitrocellulose filter in different apertures, polyester film etc.
Said each window is pasted and is covered a solid-phase reagent reaction carriers.The membrane structure of solid-phase reagent reaction carriers is separated from each other like this, and is independent mutually, can be used for the detection of a person-portion or many person-portions blood haemoglobin.
Said coupling arrangement is a cushion, and cushion has certain thickness and elasticity, and there is bonding agent on both sides, carrier substrate and carrier cover plate is carried out non-tight be connected.
Carry cover plate and formed the solid-phase reagent reaction zone with the solid-phase reagent reaction carriers, with the various chemical reaction reagent predetermined fixed of needs detection on the solid-phase reagent reaction carriers.
Sample carriers and solid-phase reagent reaction carriers contact under particular instrument control; Haemoglobin in the stripping of sample pretreating zone is sent to the solid-phase reagent reaction zone; In the solid-phase reagent reaction zone with the solid-phase reagent reaction carriers on chemical reagent react; Through dry sheet type fast detecting instrument,, detect the change color on the solid-phase reagent reaction carriers film and then calculate the concentration of measured object through light source and optical sensor.In the testing process, detector to photosignal gather, analysis and data processing.Chemical reaction process carries out under the detector thermostatic control automatically on the haemoglobin check-out console, has that reaction velocity is fast, a good reproducibility, accuracy, precision advantages of higher.
The present invention also provides the preparation method of this haemoglobin check-out console, is to realize through following step:
(1) cutting is fixing: according to specification processing and fabricating bearing substrate of working in coordination and carrying cover plate, on bearing substrate, offer sample pretreatment unit groove, on the carrying cover plate, offer window.Solid-phase reagent reaction carriers, the sample carriers of cutting correspondingly-sized are fixed on sample carriers on the sample pretreatment unit, adopt 300～500 ℃ of heat seal modes to paste the solid-phase reagent reaction carriers and cover on the window that carries cover plate;
(2) point sample: will detect the needed reaction reagent of HC, quantitatively point sample is on solid-phase reagent reaction carriers and sample carriers;
(3) bake drying: with the solid-phase reagent reaction carriers behind the point sample and sample carriers dry 30～120min in 30～60 ℃ of baking ovens;
(4) assembling: will carry cover plate and carry out non-tight with bearing substrate through coupling arrangement and be connected.
Wherein point sample is solidified with and promotes haemoglobin to change into the nitrite of methemoglobin, can make methemoglobin be converted into the sodium azide of azide methemoglobin on the solid-phase reagent reaction carriers, and adopts inorganic acid for adjusting pH 6～7.
Beneficial effect of the present invention is: the haemoglobin check-out console is applied to the HC of fast quantification detection people whole blood sample clinically.Because product of the present invention has characteristics such as be swift in response, accuracy, precision are high, multisample detects simultaneously, many-sided requirements such as routine diagnosis, emergency treatment, the examination of blood source can be satisfied in using in the historical facts or anecdotes border.
The present invention relates to designing and developing and technology path science, reasonable of product haemoglobin check-out console, automaticity is high, and stable performance is multiple functional, elegant in shape, and is convenient easy-to-use.The testing result accuracy is high, good reproducibility, and detection speed is fast, can satisfy the needs of extensive quick test on hospitals at different levels and the mobile blood-collecting carriage fully.
Description of drawings
Fig. 1 is the structural representation of single part of haemoglobin check-out console
Fig. 2 is the structural representation of four-player part haemoglobin check-out console
Fig. 3 is that four-player part haemoglobin check-out console carries cover plate and the window synoptic diagram on it
Embodiment
Below in conjunction with accompanying drawing and embodiment, the present invention is further specified.
Embodiment 1
Single part of haemoglobin check-out console
The method that the detection method of haemoglobin check-out console detects based on azide methemoglobin realizes the quantitative measurement of haemoglobin, and this method testing result is stable, degree of accuracy is high, is one of internationally recognized haemoglobin detection method.
The haemoglobin check-out console comprises sample pretreating zone and solid-phase reagent reaction zone.Wherein whole blood through dissolving born of the same parents' agent cracking haemocyte stripping haemoglobin, is sent to the solid-phase reagent reaction zone at the sample pretreating zone after the diffusion, is solidifying reaction reagent in advance on the solid phase reaction carrier film of solid-phase reagent reaction zone.Reaction reagent and haemoglobin wherein react; Finally on carrier film, produce obvious change color; Difference according to measured object Hb concentration; Demonstrate change color in various degree, carry out detection by quantitative by dry sheet type fast detecting instrument utilization reflection photometry colorimetric principle again, determine Hb concentration in the sample through change color to reaction end.Chemical equation is following:
Hb+NaNO
2→Hi
Hi+NaN
3→HiN
3
Main composition: contain following material on every haemoglobin check-out console solid-phase reagent reaction carriers and the sample carriers:
The preparation of haemoglobin check-out console: (like Fig. 1)
1. cut fixing: by cut, bearing substrate that the processing and fabricating size cooperates and carrying cover plate are hard substrate 5 and plastic strip frame 2 in the present embodiment with solid phase reaction carrier film 1, sample pad 4, loading slot 3.Sample pad 4 installed additional be fixed in loading slot 3; Solid phase reaction carrier film 1 is covered on the plastic strip frame 2 500 ℃ of heat seals.
2. point sample: by detecting the required agent prescription of haemoglobin, preparation reaction working fluid I, quantitatively 1.5-2.5 μ l/ sheet point sample is on the solid phase reaction carrier film; Reaction working fluid II, quantitatively 15-18 μ l/ sheet point sample is on sample pad.
3. dry: with the solid phase reaction carrier film 1 behind the point sample and sample pad 4 in 40 ℃ of baking ovens dry 90 minutes.
4. assembling: plastic strip frame 2 and the two-layer binder up and down of hard substrate 5 through cushion 6 are fixed together.Install drying agent, oxygen scavenger additional, be sealed in the aluminium foil bag, storage, subsequent use in the 2-8 ℃ of refrigerator.
Clinical detection:
Get 15-20 μ l finger tip tip blood, be added in the loading slot of haemoglobin check-out console, and check-out console is put in the matching used dry sheet type fast detecting instrument, the automatic display result of detector in 3 minutes.
Four-player part haemoglobin check-out console
The detection principle is the same.
Main composition
Contain following material on solid-phase reagent reaction carriers on each window of haemoglobin check-out console and the corresponding sample pad:
Every haemoglobin check-out console has 4 windows, and promptly the reagent total amount is:
The preparation of haemoglobin check-out console: (like Fig. 2)
1. cut fixing: by cut, bearing substrate that the processing and fabricating size cooperates and carrying cover plate are hard substrate 5 and plastic strip frame 2 in the present embodiment with solid phase reaction carrier film 1, sample pad 4, loading slot 3.Sample pad 4 is installed in loading slot 3; Solid phase reaction carrier film 1 is covered on the plastic strip frame 2 500 ℃ of heat seals.
2. point sample: by detecting the required agent prescription of haemoglobin, preparation reaction working fluid I, quantitatively 1.5-2.5 μ l/ sheet point sample is on the solid phase reaction carrier film; Reaction working fluid II, quantitatively 15-18 μ l/ sheet point sample is on sample pad.
3. dry: with the solid phase reaction carrier film 1 behind the point sample and sample pad 4 in 40 ℃ of baking ovens dry 120 minutes.
4. assembling: plastic strip frame 2 and the two-layer binder up and down of hard substrate 5 through cushion 6 are fixed together.Install drying agent, oxygen scavenger additional, be sealed in the aluminium foil bag, storage, subsequent use in the 2-8 ℃ of refrigerator.
Clinical detection:
Get 15-20 μ l finger tip tip blood, be added in the loading slot of haemoglobin check-out console, and check-out console is put in the matching used dry sheet type fast detecting instrument, the automatic display result of detector in 3 minutes.
Like Fig. 3, be that four-player part haemoglobin check-out console carries cover plate and the window synoptic diagram on it, in the above-described embodiments, solid phase reaction carrier film 1 all is to be fixedly mounted on the window 7 of plastic strip frame 2.
Claims (8)
1. haemoglobin check-out console; Comprise sample pretreatment unit and solid-phase reagent reaction carriers; It is characterized in that said sample pretreatment unit is several, be opened on the bearing substrate that its internal fixation is the sample carriers of point sample chemical reagent; Said solid-phase reagent reaction carriers is installed in and carries on the cover plate, and said bearing substrate fixedly mounts through coupling arrangement with the carrying cover plate.
2. haemoglobin check-out console as claimed in claim 1 is characterized in that said sample pretreatment unit is the slot type container, and body is embedded on the said bearing substrate.
3. haemoglobin check-out console as claimed in claim 1 is characterized in that said sample carriers is a kind of sample carriers of thieving paper material.
4. haemoglobin check-out console as claimed in claim 1 is characterized in that said bearing substrate is the bearing substrate of being processed by a kind of material in tygon, PVC, polypropylene and the organic glass.
5. haemoglobin check-out console as claimed in claim 1 is characterized in that being provided with on the said carrying cover plate the corresponding window in some and said sample pretreatment unit position.
6. haemoglobin check-out console as claimed in claim 1 is characterized in that said each window stickup covers a solid-phase reagent reaction carriers.
7. haemoglobin check-out console as claimed in claim 1 is characterized in that said coupling arrangement is a cushion, carries out non-tight with carrier substrate and carrier cover plate and is connected.
8. the preparation method of a haemoglobin check-out console is characterized in that being realizing through following step:
(1) cutting is fixing: according to specification processing and fabricating bearing substrate of working in coordination and carrying cover plate; On bearing substrate, offer sample pretreatment unit groove; On the carrying cover plate, offer window; Solid-phase reagent reaction carriers, the sample carriers of cutting correspondingly-sized are fixed on sample carriers on the sample pretreatment unit, adopt 300～500 ℃ of heat seal modes to paste the solid-phase reagent reaction carriers and cover on the window that carries cover plate;
(2) point sample: will detect the needed reaction reagent of HC, quantitatively point sample is on solid-phase reagent reaction carriers and sample carriers;
(3) drying: with the solid-phase reagent reaction carriers behind the point sample and sample carriers dry 30～120min in 30～60 ℃ of baking ovens;
(4) assembling: will carry cover plate and carry out non-tight with bearing substrate through coupling arrangement and be connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110216983.9A CN102384906B (en) | 2011-08-01 | 2011-08-01 | Hemoglobin detection plate and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110216983.9A CN102384906B (en) | 2011-08-01 | 2011-08-01 | Hemoglobin detection plate and its preparation method and application |
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| Publication Number | Publication Date |
|---|---|
| CN102384906A true CN102384906A (en) | 2012-03-21 |
| CN102384906B CN102384906B (en) | 2016-01-20 |
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| CN201110216983.9A Expired - Fee Related CN102384906B (en) | 2011-08-01 | 2011-08-01 | Hemoglobin detection plate and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110736845A (en) * | 2019-10-31 | 2020-01-31 | 深圳福能医疗科技有限公司 | detection device for glycosylated hemoglobin and detection method thereof |
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| CN202182864U (en) * | 2011-08-01 | 2012-04-04 | 无锡蓝德生物医药有限责任公司 | Hemoglobin detection board |
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2011
- 2011-08-01 CN CN201110216983.9A patent/CN102384906B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376254B1 (en) * | 1999-03-19 | 2002-04-23 | DRäGER SICHERHEITSTECHNIK GMBH | Biomimetic reagent system and its use |
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Cited By (1)
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| CN110736845A (en) * | 2019-10-31 | 2020-01-31 | 深圳福能医疗科技有限公司 | detection device for glycosylated hemoglobin and detection method thereof |
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