CN102218155A - Preparation method for nano-silver functional hydrocolloid medical dressing - Google Patents
Preparation method for nano-silver functional hydrocolloid medical dressing Download PDFInfo
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- CN102218155A CN102218155A CN2010101499470A CN201010149947A CN102218155A CN 102218155 A CN102218155 A CN 102218155A CN 2010101499470 A CN2010101499470 A CN 2010101499470A CN 201010149947 A CN201010149947 A CN 201010149947A CN 102218155 A CN102218155 A CN 102218155A
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Abstract
The invention relates to a preparation method for nano-silver functional hydrocolloid medical dressing, comprising the following four steps of step 1: heating and dissolving 40 to 90 weight parts of medical polyisobutene hot-melt adhesives in a mixer under the temperature of 130 to 150 DEG C so as to form a component A; step 2: under the room temperature, mixing 10 to 35 weight parts of sodium carboxymethylcellulose, 0.5 to 8 weight parts of pectins and 0.1 to 0.3 weight parts of nano-silver or 0.5 to 1 weight parts of nano-silver dispersoid to form a solid powder body, wherein the particle size of the powder body is 150 to 300 meshes; and the powder body is a component B; step 3: slowly adding the mixed component B into the component A; carrying out vacuum constant-temperature mixing for 60 to 90 minutes under the temperature of 120 to 130 DEG C; subsequently carrying out injection molding on a piece of release paper or a PU membrane; step 4: carrying out ageing treatment on formed hydrocolloid, subsequently forming shapes suitable for various wounds by extruding; and subsequently carrying out die-cutting and packaging to form a product, wherein the ageing treatment temperature is 30 to 65 DEG C; and the ageing treatment time is 72 hours. The preparation method has the advantages of overcoming the defect that black spots can be formed easily after silver micro-particles are oxidated, and being suitable for nursing severely infected wounds.
Description
Technical field
The present invention relates to a kind of preparation method of hydrocolloid medical dressing, particularly a kind of preparation method of nanometer silver activated water colloid medical dressing.
Background technology
The hydrocolloid medical dressing be a kind ofly have waterproof, anti, preserve moisture, the new pattern compress of advantage such as insulation.Used material and the effect difference of hydrocolloid medical dressing at present is very big, and the wound that bearing hydrocolloid dressing is nursed also is in different poses and with different expressions, at different wounds, needs safety good and have a hydrocolloid medical dressing of difference in functionality.
The patent of invention that relates to bearing hydrocolloid dressing from domestic patent retrieval to binomial, its publication number is respectively CN101569758A and CN101559236.The used main material of this binomial patent of invention bearing hydrocolloid dressing is adjuvants such as styrene, aliphatic petroleum resin, rubber, gelatin and sodium carboxymethyl cellulose, carboxymethyl chitosan, calcium alginate fibre, solid fine silver particle, preparation method complexity, safety remain to be proved.
Summary of the invention
The objective of the invention is in order to overcome the insecure defective of the complicated safety of existing bearing hydrocolloid dressing preparation method, invent a kind of polyisobutylene that adopts and make the preparation method that base material, nanometer silver are made the nanometer silver activated water colloid medical dressing of adjuvant.
The objective of the invention is to realize by following technical scheme:
The preparation method of described nanometer silver activated water colloid medical dressing may further comprise the steps:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of polyisobutylene medical hot melt glue 40-90 weight portion in blender, form the A component;
Step 2 with sodium carboxymethyl cellulose 10-35 weight portion, pectin 0.5-8 weight portion and nanometer silver 0.1-0.3 weight portion or nanometer silver dispersion 0.5-1 weight portion, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Good effect of the present invention is as follows: the nanometer silver activated water colloid medical dressing according to this method preparation, be embodied in the wound that is applicable to different shape, and be particularly suitable for the wound of difficult fixed position; Nanometer silver medicinal functional bearing hydrocolloid dressing of the present invention is compound by high molecular hydrophobic polyisobutylene adhesive and hydrophilic sodium carboxymethyl cellulose and nanometer silver and pectin, double effects with bonding skin and absorption wound fluid, absorb transudate from wound surface, constitute moistening environment, be of value to the growth of cambium, promote wound healing.Nanometer silver medicinal functional bearing hydrocolloid dressing of the present invention also has lasting sterilizing ability, nanometer silver can progressively enter the deep sterilization of wound from the surface of wound, therefore the bacteriocidal concentration of nanometer silver is significantly less than fine silver particle, and nanometer silver can overcome the drawback that forms black speck after the fine silver particle oxidation easily simultaneously again.The nanometer silver hydrocolloid is suitable for infecting the wound nursing that a large amount of transudates are seriously arranged.
The polyisobutylene chemical property is stable, nontoxic, be applicable to medicine of different nature, do not change the character and the therapeutical effect of medicine, and weather-proof good, soft, the good springiness of polyisobutylene, hot strength are big, moulding processability is superior, and adhesion can be regulated, and is the desirable base material of bearing hydrocolloid dressing.Be added with the bearing hydrocolloid dressing of functional adjuvant sodium carboxymethyl cellulose, pectin and nanometer silver, because the bactericidal effect of nanometer silver is better than fine silver particle greatly, so can be used for nursing the more serious wound of infection.Different wounds uses this bearing hydrocolloid dressing at different healing stages, can promote the healing of wound, reduces patient's misery.
The specific embodiment
One of implementation method:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of 65 kilograms in polyisobutylene medical hot melt glue in blender, form the A component;
Step 2 with 18 kilograms of sodium carboxymethyl cellulose, 4 kilograms of pectin and nanometer silver 150 grams, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Two of implementation method:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of 45 kilograms in polyisobutylene medical hot melt glue in blender, form the A component;
Step 2 with 20 kilograms of sodium carboxymethyl cellulose, 1 kilogram of pectin and nanometer silver dispersion 800 grams, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Three of implementation method:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of 85 kilograms in polyisobutylene medical hot melt glue in blender, form the A component;
Step 2 with 25 kilograms of sodium carboxymethyl cellulose, 7 kilograms of pectin and nanometer silver 200 grams, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Described embodiment is used for the present invention that explains, rather than limits the invention, and in the protection domain of spirit of the present invention and claim, any modification and change to the present invention makes all fall into protection scope of the present invention.
Claims (1)
1. the preparation method of a nanometer silver activated water colloid medical dressing, it is characterized in that: the preparation method of described nanometer silver activated water colloid medical dressing may further comprise the steps:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of polyisobutylene medical hot melt glue 40-90 weight portion in blender, form the A component;
Step 2 with sodium carboxymethyl cellulose 10-35 weight portion, pectin 0.5-8 weight portion and nanometer silver 0.1-0.3 weight portion or nanometer silver dispersion 0.5-1 weight portion, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101499470A CN102218155A (en) | 2010-04-16 | 2010-04-16 | Preparation method for nano-silver functional hydrocolloid medical dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101499470A CN102218155A (en) | 2010-04-16 | 2010-04-16 | Preparation method for nano-silver functional hydrocolloid medical dressing |
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| CN102218155A true CN102218155A (en) | 2011-10-19 |
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| CN2010101499470A Pending CN102218155A (en) | 2010-04-16 | 2010-04-16 | Preparation method for nano-silver functional hydrocolloid medical dressing |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103957947A (en) * | 2011-12-02 | 2014-07-30 | 伊西康公司 | Hemostatic bioabsorbable device with polyethylene glycol binder |
| CN106729961A (en) * | 2016-12-19 | 2017-05-31 | 广东泰宝医疗器械技术研究院有限公司 | A kind of moisture absorption antibacterial bearing hydrocolloid dressing and preparation method thereof |
| CN111514370A (en) * | 2020-04-13 | 2020-08-11 | 青岛海洋生物医药研究院 | Alginate hydrocolloid dressing with high absorption performance and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559236A (en) * | 2009-02-12 | 2009-10-21 | 泰州市三易医疗科技有限公司 | Silver-bearing hydrocolloid dressing and preparation method |
| CN101569758A (en) * | 2008-12-31 | 2009-11-04 | 褚加冕 | Preparation method for medical use hydrocolloid dressing |
-
2010
- 2010-04-16 CN CN2010101499470A patent/CN102218155A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569758A (en) * | 2008-12-31 | 2009-11-04 | 褚加冕 | Preparation method for medical use hydrocolloid dressing |
| CN101559236A (en) * | 2009-02-12 | 2009-10-21 | 泰州市三易医疗科技有限公司 | Silver-bearing hydrocolloid dressing and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 秦益民: "《功能性医用敷料》", 28 February 2007, article "功能性医用敷料", pages: 160-163 * |
| 秦益民: "在医用敷料中添加银离子的方法", 《纺织学报》, vol. 27, no. 12, 31 December 2006 (2006-12-31) * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103957947A (en) * | 2011-12-02 | 2014-07-30 | 伊西康公司 | Hemostatic bioabsorbable device with polyethylene glycol binder |
| CN103957947B (en) * | 2011-12-02 | 2018-09-07 | 伊西康公司 | Use the bioabsorbable hemostasis device of polyethylene glycol binder |
| CN106729961A (en) * | 2016-12-19 | 2017-05-31 | 广东泰宝医疗器械技术研究院有限公司 | A kind of moisture absorption antibacterial bearing hydrocolloid dressing and preparation method thereof |
| CN111514370A (en) * | 2020-04-13 | 2020-08-11 | 青岛海洋生物医药研究院 | Alginate hydrocolloid dressing with high absorption performance and preparation method thereof |
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Application publication date: 20111019 |