CN102204978A - Medicinal composition for treating cancer pain and preparation thereof - Google Patents
Medicinal composition for treating cancer pain and preparation thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicaments, in particular to a medicinal composition for treating cancer pain in a synergistic way and a preparation thereof. The medicinal composition for treating cancer pain in a synergistic way is prepared from Chinese herbal medicines, wherein dried orange peel, bitter orange and magnolia officinalis have the effect of regulating qi; herba oldenlandiae, prepared rhubarb, kudzu root, desmodium and herba artemisiae capillaris have the effects of clearing heat and expelling dampness; gamene, red paeonia and red-rooted salvia root have the effect of removing blood stasis; and Chinese angelica root, white peony root and liquoric root have the effect of strengthening. By adopting the medicinal composition, the problems of the influence of phlegm on normal running of qi, dysfunction of qi and cancer pain caused by stagnation of the circulation of vital energy are solved. The medicinal composition is prepared from natural Chinese medicinal herbs, can be used for effectively eliminating cancer pain, does not have any remarkable toxic or side effect, and has an analgesic function.
Description
Technical field
The invention belongs to field of pharmaceutical technology, in particular a kind of pharmaceutical composition of Synergistic treatment cancerous pain and preparation thereof.
Background technology
Pain is very common the cancer patient, especially behind middle and advanced stage because of tumor invading peripheral nerve tissue, organ, and the symptom that all pain can occur and have an intense pain such as osseous tissue, and pain is to influence cancer patient's quality of life, impel the state of an illness to worsen, and influence one of of paramount importance factor of antineoplaston and curative effect etc., so eliminate cancerous pain for the survival rate that improves the patient, the disease controlling development, and improve survival rate etc. and have extremely important clinical meaning, yet cancer three rescue by stages that WHO proposes, use conveniently although have, rapid-action, the pain palliation efficacy outstanding feature, but, the lasting analgesia effect of opioid drug generation needs to increase obvious toxic and side effects that dosage brings because having, can not stop using or use instead constitute drug dependence, and middle and terminal cancer patient analgesic continues to be applied to the later stage and the problem that analgesia effect significantly descends degradation occurs, so opioid drug is actual is not the desirable or perfect analgesic of a class, but by retrieval and find no the medicine that can replace opioid drug to solve cancerous pain.Though and tcm treatment according to syndrome differentiation thinks have ten kinds to execute the method for controlling and have the analgesic curative effect, but actual analgesic effect does not also reach the degree that other people convinces, curative effect more can not be mentioned in the same breath with opioid drug, therefore, seek and a kind ofly can effectively alleviate cancerous pain, the medicine that does not have obvious toxic-side effects again, though may be a kind of Utopian pursuing one's goal, but the traditional Chinese medical science thinks that cancerous pain and expectorant stop in turbid, hinder the relevant theory of QI-blood circulation, then provide a treatment approach for excavating the traditional Chinese medical herbal treatment cancerous pain, therefore develop Chinese medicine as a kind of Synergistic method treatment cancerous pain, and seek more effective, safer, and the littler medicine of toxic and side effects, be meaning of the present invention.
Chinese invention patent application (application number: 200910229312.9 applyings date: 2009-10-23) disclose crust cloth cream and preparation method thereof of treatment cancerous pain, form by the certain weight ratio proportioning by duck yolk emulsifiable oil, Mylabris, artificial Calculus Bovis, Sanguis Draxonis, Rhizoma Corydalis, Radix Notoginseng, Semen Strychni(processed), Flos Daturae, Herba Hedyotidis Diffusae, Mentholum, Squama Manis preparata, artificial Moschus, Radix Codonopsis, Fructus Jujubae, Colla Plastri Testudinis and Colla cornus cervi, preparation method is the Chinese medical concrete of being made by Radix Codonopsis, Flos Daturae, Herba Hedyotidis Diffusae, add jujube pulp, duck yolk emulsifiable oil, stir, as cream matter; Adding Testudinis, deer two glue again, add water and be boiled into colloid, is fine powder by artificial Calculus Bovis, Sanguis Draxonis, Rhizoma Corydalis, Radix Notoginseng, Semen Strychni, Squama Manis preparata, and Mylabris, Mentholum, artificial Moschus add in the Chinese medical concrete, stir and dispose.
Chinese invention patent application (application number: 200810196075.6 applyings date: 2008-09-12) disclose a kind of Chinese medicine composition for the treatment of cancerous pain and preparation method thereof, made by crude drug Armadillidium 3-5 weight portion, Rhizoma Paridis 4-weight portion, Piper longum 3-5 weight portion, Rhizoma Typhonii (processed) 3-6 weight portion, Olibanum (processed) 1-3 weight portion, Rhizoma Arisaematis (processed) 2-6 weight portion; Through pharmacological effect test and clinical practice, cancer pain is put down has good analgesic activity, improves cancer patient's quality of life, and has the good anticancer effect; Enhancing non-specific immunity function and cellular immune function are obvious.
Chinese invention patent application (application number: 02114986.0 applying date: 2002-03-21) disclose a kind of medicine that is used for stopping cancer pain and preparation method thereof, made: Caulis Sinomenii 4～200, Herba Chelidonii 5～230, Radix Schefflerae Arboricolae 10～250 by the following weight proportion raw material.The invention also discloses manufacturing method for above mentioned medicine: (1) Herba Chelidonii, Caulis Sinomenii add alcohol reflux, merge alcohol extract, and be concentrated, transfers pH, filters, and filtrate transfers to alkalescence, merges with chloroform extraction, reclaims, and the residue vacuum drying gets total alkaloids; (2) Radix Schefflerae Arboricolae decocts with water, and merges, and filtrate decompression concentrates, and with the ethanol precipitation processing, reclaims ethanol, dilution, and cold preservation, filtrate is transferred pH, adds ethanol again, and filtrate decompression concentrates, and vacuum drying gets the dried cream of Radix Schefflerae Arboricolae; (3) get above-mentioned total alkaloids, the dried cream of Radix Schefflerae Arboricolae, add the injection water, transfer pH, add tween 80, benzyl alcohol, filter, embedding, sterilization makes injection.
Summary of the invention
In order to overcome ubiquitous drug dependence in the opioid drug treatment cancerous pain, medicine obvious toxic and side effects that increment brings, and continue to be applied to the later stage and can not bring into play problem of analgesic effect etc., an object of the present invention is to provide a kind of and can effectively stop cancerous pain, and do not have the pharmaceutical composition that obvious toxic-side effects has the natural Chinese medicinal herb of analgesic activity.Another object of the present invention provides the preparation of aforementioned pharmaceutical compositions.
In order to realize first above-mentioned purpose, the present invention has adopted following technical scheme:
A kind of pharmaceutical composition for the treatment of the Chinese herbal medicine of cancerous pain, this pharmaceutical composition is obtained by the feedstock production of following weight parts:
Herba Lysimachiae 6-10 weight portion, Herba Hedyotidis Diffusae 11-14 weight portion, Herba Artemisiae Scopariae 7-10 weight portion,
Radix Et Rhizoma Rhei 7-11 weight portion, Pericarpium Citri Reticulatae 3-6 weight portion, Fructus Aurantii 2-4 weight portion,
Magnolia officinalis Rehd. et wils. 1-3 weight portion, Radix Puerariae 11-15 weight portion, Radix Rubiae 10-14 weight portion,
Radix Paeoniae Rubra 6-9 weight portion, Radix Glycyrrhizae 1-4 weight portion, Radix Angelicae Sinensis 2-5 weight portion,
Radix Salviae Miltiorrhizae 4-6 weight portion, Radix Paeoniae Alba 3-5 weight portion.
Chinese medicine among the present invention is all on the books on Chinese Pharmacopoeia or Chinese medicine voluminous dictionary.
In order to realize second above-mentioned purpose, the present invention has adopted following technical scheme:
A kind of pharmaceutical preparation for the treatment of the Chinese herbal medicine of cancerous pain, this pharmaceutical preparation is obtained by above-mentioned preparation of pharmaceutical compositions.
Aforementioned pharmaceutical compositions is prepared into the dosage form on the pharmaceutics meaning, comprises powder, granule, and capsule, tablet or liquid oral dosage form, concrete formulation method is as follows.
1, a kind of Chinese herbal medicine powder for the treatment of cancerous pain, this Chinese herbal medicine powder are cleaned by the raw material of above-mentioned weight portion, are dried to water content 5-10% under 80-100 ℃ temperature conditions, pulverize 200 mesh sieves, mix homogeneously, and sterilization obtains powder.
2, a kind of Chinese herbal medicine capsule for the treatment of cancerous pain, this Chinese herbal medicine capsule obtains full plastic powder wafer by the above-mentioned powder branch that the makes capsule of packing into.
3, a kind of Chinese herbal medicine granule for the treatment of cancerous pain, the Chinese herbal medicine granule is prepared through following step by the raw material of above-mentioned weight portion:
(1) medicine of getting in the above-mentioned prescription is cleaned, and adds the water that 3-5 doubly measures, heating extraction 2 times, and each 1-2 hour, extracting solution merged filtration, obtains filtrate for later use;
(2) filtrate decompression is concentrated into 65 ℃ of intermittent fever to survey relative densities is 1.28-1.30, and it is standby to obtain thick paste;
(3) get the conventional adjuvant mix homogeneously for preparing granule of 1 part of thick paste and 2-3 part, be prepared into soft material, make granule, dry under 80-100 ℃ temperature conditions, obtain granule.
4, a kind of Chinese herbal medicine tablet for the treatment of cancerous pain, this Chinese herbal medicine tablet is by the adjuvant that adds an amount of conventional preparation tablet in the above-mentioned granule that makes, and compacting obtains tablet in flakes.
5, a kind of Chinese herbal medicine oral liquid for the treatment of cancerous pain, this Chinese herbal medicine oral liquid is prepared through following step by the raw material of above-mentioned weight portion:
(1) medicine of getting in the above-mentioned prescription is cleaned, and adds the water that 3-5 doubly measures, heating extraction 2 times, and each 1-2 hour, extracting solution merged filtration, obtains filtrate for later use;
(2) to be concentrated into relative density be 1.01-1.02 to filtrate decompression, and the adjuvant that adds conventional preparation liquid oral obtains oral liquid.
The present invention is owing to take above-mentioned measure, and all raw material is Chinese herbal medicine, wherein Pericarpium Citri Reticulatae, Fructus Aurantii, Magnolia officinalis Rehd. et wils. regulate the flow of vital energy Herba Hedyotidis Diffusae, Radix Et Rhizoma Rhei, Radix Puerariae, Herba Lysimachiae, the Herba Artemisiae Scopariae clearing heat and expelling damp, Radix Rubiae, Radix Paeoniae Rubra and Radix Salviae Miltiorrhizae blood stasis dispelling, Radix Angelicae Sinensis, the therapeutic modality of the Radix Paeoniae Alba and Radix Glycyrrhizae tonification solves the turbid normal operation that influences gas of expectorant, cause the functional disorder of gas, cause that the problem of cancerous pain appears in the stagnation of QI.Pharmaceutical composition of the present invention is a kind ofly can effectively stop cancerous pain, and there is not obvious toxic-side effects, pharmaceutical composition with natural Chinese medicinal herb of analgesic activity, overcome ubiquitous drug dependence in the opioid drug treatment cancerous pain, medicine obvious toxic and side effects that increment brings, and continue to be applied to the later stage and can not bring into play problem of analgesic effect etc.
The specific embodiment
Embodiment 1
Prescription: Herba Lysimachiae 8 weight portions, Herba Hedyotidis Diffusae 12 weight portions, Herba Artemisiae Scopariae 8 weight portions, Radix Et Rhizoma Rhei 7 weight portions, Pericarpium Citri Reticulatae 4 weight portions, Fructus Aurantii 3 weight portions, Magnolia officinalis Rehd. et wils. 2 weight portions, Radix Puerariae 12 weight portions, Radix Rubiae 13 weight portions, Radix Paeoniae Rubra 8 weight portions, Radix Glycyrrhizae 2 weight portions, Radix Angelicae Sinensis 3 weight portions, Radix Salviae Miltiorrhizae 5 weight portions, the Radix Paeoniae Alba 4 weight portions;
Preparation method: the medicine of getting above-mentioned prescription is cleaned, and is dried to water content 5-10% under 80-100 ℃ temperature conditions, pulverizes 200 mesh sieves, mix homogeneously, and sterilization obtains powder, with the resulting powder branch capsule of packing into, obtains full plastic powder wafer.
Embodiment 2
Prescription: Herba Lysimachiae 6 weight portions, Herba Hedyotidis Diffusae 13 weight portions, Herba Artemisiae Scopariae 9 weight portions, Radix Et Rhizoma Rhei 10 weight portions, Pericarpium Citri Reticulatae 5 weight portions, Fructus Aurantii 4 weight portions, Magnolia officinalis Rehd. et wils. 2 weight portions, Radix Puerariae 14 weight portions, Radix Rubiae 12 weight portions, Radix Paeoniae Rubra 8 weight portions, Radix Glycyrrhizae 3 weight portions, Radix Angelicae Sinensis 5 weight portions, Radix Salviae Miltiorrhizae 4 weight portions, the Radix Paeoniae Alba 5 weight portions;
Preparation method: 1. the medicine of getting in the above-mentioned prescription is cleaned, add the water that 3-5 doubly measures, heating extraction 2 times, each 1-2 hour, extracting solution merged filtration, obtain filtrate for later use: 2. filtrate decompression is concentrated into the 650C intermittent fever to survey relative density is 1.28-1.30, it is standby to obtain thick paste: 3. get the adjuvant mix homogeneously of the conventional preparation of 1 part of thick paste and 2-3 part granule, be prepared into soft material, make granule, 80-1000C, temperature conditions under dry, obtain granule.
Embodiment 3
Prescription: Herba Lysimachiae 10 weight portions, Herba Hedyotidis Diffusae 11 weight portions, Herba Artemisiae Scopariae 8 weight portions, Radix Et Rhizoma Rhei 10 weight portions, Pericarpium Citri Reticulatae 5 weight portions, Fructus Aurantii 2 weight portions, Magnolia officinalis Rehd. et wils. 1 weight portion, Radix Puerariae 12 weight portions, Radix Rubiae 13 weight portions, Radix Paeoniae Rubra 8 weight portions, Radix Glycyrrhizae 3 weight portions, Radix Angelicae Sinensis 2 weight portions, Radix Salviae Miltiorrhizae 6 weight portions, the Radix Paeoniae Alba 6 weight portions;
Preparation method: identical with embodiment 2 preparation methoies, just obtain granule after, in granule, add the adjuvant of an amount of conventional preparation tablet again, compacting obtaining tablet in flakes.
Embodiment 4
Prescription: Herba Lysimachiae 7 weight portions, Herba Hedyotidis Diffusae 14 weight portions, Herba Artemisiae Scopariae 9 weight portions, Radix Et Rhizoma Rhei 11 weight portions, Pericarpium Citri Reticulatae 5 weight portions, Fructus Aurantii 4 weight portions, Magnolia officinalis Rehd. et wils. 2 weight portions, Radix Puerariae 13 weight portions, Radix Rubiae 11 weight portions, Radix Paeoniae Rubra 7 weight portions, Radix Glycyrrhizae 3 weight portions, Radix Angelicae Sinensis 3 weight portions, Radix Salviae Miltiorrhizae 5 weight portions, the Radix Paeoniae Alba 3 weight portions;
Preparation method: 1. the medicine of getting in the above-mentioned prescription is cleaned, and adds the water that 3-5 doubly measures, heating extraction 2 times, and each 1-2 hour, extracting solution merged filtration, obtains filtrate for later use; 2. to be concentrated into relative density be 1.01-1.02 to filtrate decompression, and the adjuvant that adds conventional preparation liquid oral obtains oral liquid.
The test example
Prescription: Herba Lysimachiae 8 weight portions, Herba Hedyotidis Diffusae 13 weight portions, Herba Artemisiae Scopariae 9 weight portions, Radix Et Rhizoma Rhei 10 weight portions, Pericarpium Citri Reticulatae 5 weight portions, Fructus Aurantii 3 weight portions, Magnolia officinalis Rehd. et wils. 2 weight portions, Radix Puerariae 12 weight portions, Radix Rubiae 13 weight portions, Radix Paeoniae Rubra 7 weight portions, Radix Glycyrrhizae 3 weight portions, Radix Angelicae Sinensis 4 weight portions, Radix Salviae Miltiorrhizae 5 weight portions, the Radix Paeoniae Alba 4 weight portions.
The present invention is prepared into water decoction as supporting priority 47 examples and 59 routine cancerous pain patients has been carried out the observational study of termination pain, process of clinical application and result are as follows:
Purpose: by the I degree that the tumor patient to the different tissues organ presents, II degree and III degree cancerous pain carry out clinical observation treatment, investigate water decoction as the primary action of cooperative drug in stopping cancerous pain.
Method: experiment is divided into: treatment group, water decoction is worked in coordination with the nonspecific immunity medicine, matched group is selected per 8 hours of treatment with chemotherapy associating tramadol hydrochloride 50mg and 4 hours clothes once, per 8 hours of chemotherapy combined morphine hydrochloride slow releasing tablet 30mg and 4 hours clothes are once, finally that the consumption minimum of morphine slow releasing tablet is 180mg, that maximum is 330mg, observes the curative effect effect of two group termination cancerous pain.
The result, first, the treatment group, after the administration after 8 days to the I degree, II degree and III degree cancerous pain patient all have the curative effect that stops pain, stop the pain rate and reach 72%, remove in the therapeutic process and have the gastrointestinal reaction in early days, as slight stomachache, pernicious, and diarrhoea is outside 2-3 time/day, there is not other any bad and toxic and side effects, present the curative effect that stops cancerous pain and do not exist and continue the application need increment, continue to use the curative effect effect and reduce, and the performance that does not have the pain bounce-back after stopping using, though and the curative effect of matched group termination pain also has relatively P＞0.05 of two groups of curative effects of 68.18%(, but matched group has dizzy except that be better than the treatment group on the analgesic onset time not statistically significant),, drowsiness, pernicious, vomiting, and the symptom of general malaise, keeping analgesia effect need increase drug dose, and can not change medicine and inactive medicine etc.
Second batch, treatment group (fine setting of Chinese herbal medicine dosage), after the administration after 3 days to the I degree, II degree and III degree cancerous pain patient all have the curative effect that stops pain, stop the pain rate up to 81.84%, except still having slight gastrointestinal reaction, there is not other any bad and toxic and side effects, and the curative effect of matched group termination pain still is relatively P＞0.05, still a no difference of science of statistics of 70.45%, two group of curative effect.
Conclusion, water decoction be as cooperative drug, in the treatment that stops cancerous pain except that having the highly significant effect, compare with the morphine hydrochloride slow releasing tablet with tramadol hydrochloride, stop the curative effect no significant difference of cancerous pain, slight gastrointestinal reaction is only arranged, without any side effects.
Claims (8)
1. pharmaceutical composition for the treatment of the Chinese herbal medicine of cancerous pain is characterized in that this pharmaceutical composition is obtained by the feedstock production of following weight parts:
Herba Lysimachiae 6-10 weight portion, Herba Hedyotidis Diffusae 11-14 weight portion, Herba Artemisiae Scopariae 7-10 weight portion,
Radix Et Rhizoma Rhei 7-11 weight portion, Pericarpium Citri Reticulatae 3-6 weight portion, Fructus Aurantii 2-4 weight portion,
Magnolia officinalis Rehd. et wils. 1-3 weight portion, Radix Puerariae 11-15 weight portion, Radix Rubiae 10-14 weight portion,
Radix Paeoniae Rubra 6-9 weight portion, Radix Glycyrrhizae 1-4 weight portion, Radix Angelicae Sinensis 2-5 weight portion,
Radix Salviae Miltiorrhizae 4-6 weight portion, Radix Paeoniae Alba 3-5 weight portion.
2. pharmaceutical preparation for the treatment of the Chinese herbal medicine of cancerous pain is characterized in that this pharmaceutical preparation is obtained by the described preparation of pharmaceutical compositions of claim 1.
3. pharmaceutical preparation for the treatment of the Chinese herbal medicine of cancerous pain, the dosage form that it is characterized in that this pharmaceutical preparation is powder, granule, capsule, tablet or liquid oral.
4. a Chinese herbal medicine powder for the treatment of cancerous pain is characterized in that the raw material of this Chinese herbal medicine powder by the described weight portion of claim 1, cleans, under 80-100 ℃ temperature conditions, be dried to water content 5-10%, pulverized 200 mesh sieves, mix homogeneously, sterilization obtains powder.
5. Chinese herbal medicine capsule for the treatment of cancerous pain is characterized in that this Chinese herbal medicine capsule by the described powder branch of claim 4 capsule of packing into, obtains full plastic powder wafer.
6. Chinese herbal medicine granule for the treatment of cancerous pain is characterized in that this Chinese herbal medicine granule is prepared through following step by the raw material of the described weight portion of claim 1:
(1) medicine of getting in the above-mentioned prescription is cleaned, and adds the water that 3-5 doubly measures, heating extraction 2 times, and each 1-2 hour, extracting solution merged filtration, obtains filtrate for later use;
(2) filtrate decompression is concentrated into 65 ℃ of intermittent fever to survey relative densities is 1.28-1.30, and it is standby to obtain thick paste;
(3) get the conventional adjuvant mix homogeneously for preparing granule of 1 part of thick paste and 2-3 part, be prepared into soft material, make granule, dry under 80-100 ℃ temperature conditions, obtain granule.
7. a Chinese herbal medicine tablet for the treatment of cancerous pain is characterized in that this Chinese herbal medicine tablet by the adjuvant that adds an amount of conventional preparation tablet in the described granule of claim 6, and compacting obtains tablet in flakes.
8. Chinese herbal medicine oral liquid for the treatment of cancerous pain is characterized in that this Chinese herbal medicine oral liquid is prepared through following step by the raw material of the described weight portion of claim 1:
(1) medicine of getting in the above-mentioned prescription is cleaned, and adds the water that 3-5 doubly measures, heating extraction 2 times, and each 1-2 hour, extracting solution merged filtration, obtains filtrate for later use;
(2) to be concentrated into relative density be 1.01-1.02 to filtrate decompression, and the adjuvant that adds conventional preparation liquid oral obtains oral liquid.
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| CN2011101398099A CN102204978B (en) | 2011-05-27 | 2011-05-27 | Medicinal composition for treating cancer pain and preparation thereof |
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| CN2011101398099A CN102204978B (en) | 2011-05-27 | 2011-05-27 | Medicinal composition for treating cancer pain and preparation thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456543A (en) * | 2017-10-09 | 2017-12-12 | 李昌法 | A kind of department of anesthesia is used for the pharmaceutical composition for treating cancer pain |
| CN109248304A (en) * | 2018-11-28 | 2019-01-22 | 李玉春 | A kind of department of anesthesia is used to treat the pharmaceutical composition of cancer pain |
| CN111991490A (en) * | 2020-09-25 | 2020-11-27 | 唐坤术 | A Chinese medicinal composition for treating pain due to late stage cancer, and its preparation method |
-
2011
- 2011-05-27 CN CN2011101398099A patent/CN102204978B/en not_active Expired - Fee Related
Non-Patent Citations (3)
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| 《中国中医药信息杂志》 20050531 吴勉华 癌性疼痛的中医药研究现状与对策 105-108 1-8 第12卷, 第5期 * |
| 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 20100715 赵印涛 中医药治疗30例轻中度癌痛患者疗效及用药规律的临床研究 E056-365 1-8 , 第7期 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456543A (en) * | 2017-10-09 | 2017-12-12 | 李昌法 | A kind of department of anesthesia is used for the pharmaceutical composition for treating cancer pain |
| CN109248304A (en) * | 2018-11-28 | 2019-01-22 | 李玉春 | A kind of department of anesthesia is used to treat the pharmaceutical composition of cancer pain |
| CN111991490A (en) * | 2020-09-25 | 2020-11-27 | 唐坤术 | A Chinese medicinal composition for treating pain due to late stage cancer, and its preparation method |
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| CN102204978B (en) | 2012-07-25 |
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