CN104013929B - Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof - Google Patents
Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and a preparation method thereof. The preparation method comprises the following steps: (1) respectively distilling rhizoma atractylodis, radix clematidis, turmeric, radix angelicae pubescentis and notopterygium root, and extracting volatile oil; (2) adding water into the decoction dregs of the rhizoma atractylodis and radix clematidis and red flower for decocting and extracting; (3) adding water into the decoction dregs of the turmeric, radix angelicae pubescentis and notopterygium root, golden cypress and Caulis Spatholobi for decocting and extracting; (4) extracting the decoction dregs by using ethanol; (5) adding the filtrates in the step (2) and the step (3) into the distilled aqueous solution in the step (1), and concentrating into extract for later use; (6) adding apiary and the fried frankincense into ethanol for extracting, and concentrating into thick paste; and (7) grinding nine raw material medicines such as Bungarus Parvus, long-noded pit viper, zaocys dhumnade, ground beeltle, fried myrrh, scorpio, centipede, earthworm and cassia twig, and screening for later use; merging the thick paste obtained in the steps (4), (5) and (6), performing dry mixing on the raw medicine powder in the step (7), wetting the extract, uniformly mixing, preparing granules, spraying the volatile oil, moistening and performing split charging. The method has the characteristic that the extraction rate of active ingredients is increased.
Description
The divisional application that the application is the applying date is on 06 01st, 2012, application number is 201210177637.9, denomination of invention is " a kind of rheumatic pain killing medicine and preparation method for the treatment of rheumatic arthritis and rheumatoid arthritis ".
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of rheumatism, i.e. a kind of rheumatic pain killing medicine and preparation method for the treatment of rheumatic arthritis and rheumatoid arthritis.
Background technology
In the prior art, rheumatic arthritis, rheumatoid arthritis are modern medicine names of disease, and the numbness being equivalent to Chinese medicine is sick.Arthromyodynia is lasted longer, recurrent exerbation, joint stiffness and deforming, and pain is violent, unable to flex and stretch the extremities, or pain is numb.The cause of disease of primary disease is for endogenous cause of ill with the weak insufficiency of vital energy and blood of ferritic; The pathogen such as wind, cold, wet, heat is the prognosis of the inducement causing primary disease, primary disease, and general multipole is stupid to twine, and is easy to recurrent exerbation, not easily eradicates, and part severe patient easily causes permanent disbility, and even dead.At present, domestic a lot of medical personnel utilizes Chinese medicine to cure the disease and receives certain effect.But it is all not ideal enough.Rheumatic pain killing capsule is the pure Chinese medicinal preparation (National Drug Administration standard WS-522-(Z-99)-2002 that national official approval is produced), Tonghua Golden-Horse Pharmaceutical Industry Co., Ltd. produces, authentication code: the accurate word Z20020129 of traditional Chinese medicines, clinical efficacy is definite, have received comparatively satisfied curative effect.Formula: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g.The preparation method of rheumatic pain killing capsule is: get Rhizoma Atractylodis, Rhizoma Curcumae Longae adds water moistening, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four taste decoct with water three times, amount of water is followed successively by 10,8,8 times, time is followed successively by 2,1.5,1 hours, filter, merging filtrate, add Rhizoma Atractylodis, Rhizoma Curcumae Longae distillation after aqueous solution, being concentrated into relative density is 1.30(60-70 DEG C) extractum, for subsequent use.Bungarus Parvus, Agkistrodon, Zaocys, Nidus Vespae, Flos Carthami, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Olibanum (stir-fry) Radix Angelicae Pubescentis, Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi etc. 13 taste pulverize, sieve for subsequent use, get crude drug dried bean noodles mixed 30 minutes, add above-mentioned standby stream extractum wet mixing 30 minutes again, mixing, makes granule, dry, granulate, sprays into volatile oil, moistening, subpackage, to obtain final product.But because this medicine is researched and developed comparatively early, the effective ingredient of part medical material must to making full use of, and comparatively large by dosing, therefore production technology needs improvements in addition.Active constituents in vine stem of Spatholobus suberectus in prescription is flavonoid and glycoside, take ononin as representative, and these compositions is better fat-soluble, dissolubility is in the hot water limited, and former technique extracting method is water extraction, greatly limit the extraction of effective ingredient, cause fat-soluble effective ingredient to have too many waste.One of the main component of Radix Clematidis, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii volatile oil, by former PROCESS FOR TREATMENT, falls total loss.And Cortex Phellodendri, Rhizoma Curcumae Longae, active ingredient in Rhizoma Et Radix Notopterygii not only have water-soluble components, also has a large amount of fat-soluble active ingredients.The main component of Nidus Vespae, Olibanum is water-soluble hardly, is soluble in hot ethanol.Extract can ensure, under the prerequisite that effective ingredient does not run off, to remove the impurity such as invalid components with hot ethanol.Flos Carthami is dry and pulverizing not easily, and main component runs off serious in dry run.Its main component glycoside, flavonoid (Carthamus yellow has antiinflammatory and anthydropic effect) good water solubility.Therefore answer water extraction.In original prescription, Flos Carthami, Radix Angelicae Pubescentis, Nidus Vespae, Olibanum production technology are that pulverizing is used as medicine, and cause patient's dosing comparatively large, each 5, every 0.3g, every day three times.And under the prerequisite ensureing medicine effect, carry out extraction processing, reduce dose, but do not lessen the curative effect.Based on the object of the clinical efficacy to above-mentioned medical material Appropriate application and further raising rheumatic pain killing capsule, we are on the basis not changing former technology preparation, drug dose and former main technique, carry out the optimization of technique, invent a kind of simple, easy, production technology of being adapted to industrialized great production.
Summary of the invention
In order to solve the problem, the object of the invention be to provide a kind of simple, easy, be adapted to industrialized great production, the preparation method of the rheumatic pain killing medicine of the more optimal treatment rheumatic arthritis of technique, rheumatoid arthritis.
Technical solution of the present invention is: a kind of preparation method for the treatment of the rheumatic pain killing medicine of rheumatic arthritis and rheumatoid arthritis, and its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis adds water moistening, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter, merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters, merging filtrate;
4. the medicinal residues after step 3. being extracted add 3-15 times amount 30-90% ethanol extraction 2-3 time, each 1-2 hour, filter, merging filtrate, reclaim ethanol extremely without alcohol taste, with 3-10 times amount hot water, temperature 40-100 DEG C, fully dissolves, filtered while hot, filtrate is concentrated into paste, for subsequent use;
5. by step 2. with step 3. in filtrate add step 1. distill after aqueous solution, being concentrated into relative density is 1.30,60-70 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (stir-fry) add 3-10 times amount ethanol (30-90%), 30-60 DEG C, soak 2-3 times, each 1-24 hours, filter, merging filtrate, reclaim ethanol to without alcohol taste, are concentrated into paste, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use;
By step 4., 5., 6. gained thick paste merge; Get step 7. mixed 30 minutes of crude drug dried bean noodles, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mixing, makes granule, and dry, granulate, spray into step 1. gained volatile oil, moistening, subpackage, to obtain final product.
Dose: for capsule: each 3 ~ 4, every 0.3 ~ 0.4g, every day three times.
By comparing the pharmacy before and after the improvement of technique and pharmacodynamics, result is as follows:
1, the comparison of the content of effective ingredient before and after process modification
The examination criteria of the berberine hydrochloride set up according to quality standard and the seminar of pharmacopeia detects 3 batches of new and old handicraft products, and result is as follows:
The content of effective ingredient before and after table 1 process modification
As can be seen from experimental result, new technology effective ingredient content of berberine hydrochloride improves about 100% than former technique, and new technology accounts for clear superiority.
Advantage of the present invention is: carry out preparation after 1. fully being extracted by the effective ingredient in Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Rhizoma Curcumae Longae, medicinal residues, add the extraction of volatile oil in Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Radix Clematidis, improve the rate of transform of effective ingredient, make full use of medical material; Character according to medicine effective ingredient changes extraction process into Flos Carthami, Radix Angelicae Pubescentis, Nidus Vespae, the former pulverizing medication of Olibanum, increases active, removes invalid components and impurity.2. the extraction ratio of effective ingredient increases, and pharmacologically active significantly increases, and content of berberine hydrochloride improves 100% than former technique.3. under the prerequisite ensureing Flos Carthami, Radix Angelicae Pubescentis, Nidus Vespae, Olibanum curative effect, carry out extraction processing, reduce dose, but do not lessen the curative effect.4. this technique simple, easy, more optimize, be adapted to industrialized great production.5. experiment shows, present invention process can extract more effective ingredient and play the therapeutical effect of medicine, the clinical efficacy of medicine can be ensured better, for arthralgia pain (rheumatic arthritis, rheumatoid arthritis) simultaneous occurrence of cold and heat syndromes, disease sees muscle arthrosis pain, swelling, joint motion is limited, morning is stiff, and the treatment of local pyrexia etc., can meet clinical treatment needs better.
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.
Detailed description of the invention
Embodiment 1
The preparation method of rheumatic pain killing capsule, its step is as follows:
1. crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
2. get Rhizoma Atractylodis, Radix Clematidis adds water moistening, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use.Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use.
3. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter, merging filtrate.
4. by the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, decoct with water three times with Cortex Phellodendri, Caulis Spatholobi, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters, merging filtrate.
5. medicinal residues add 3-15 times amount 30-90% ethanol extraction 2-3 time, each 1-2 hour, filter, merging filtrate, reclaim ethanol to without alcohol taste, fully dissolve (boiling can be heated to if desired) with 3-10 times amount hot water (as 40-100 DEG C), filtered while hot, filtrate is concentrated into paste, for subsequent use.
6. by step 3. with step 4. in filtrate add step 2. distill after aqueous solution, being concentrated into relative density is 1.30(60-70 DEG C) extractum, for subsequent use.
7. Nidus Vespae, Olibanum (stir-fry) add 3-10 times amount hot ethanol (30-60 DEG C) and soak 2-3 times, each 1-24 hours, filter, merging filtrate, reclaim ethanol to without alcohol taste, are concentrated into paste, for subsequent use.
8. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi etc. nine taste pulverize, sieve for subsequent use
9. by step 5., 6., 7. gained thick paste merge, get step 8. mixed 30 minutes of crude drug dried bean noodles, then add above-mentioned extractum wet mixing 30 minutes, mixing, makes granule, and dry, granulate, sprays into volatile oil, and moistening makes granule, incapsulates, and makes 1000, to obtain final product
Dose: for capsule: each 3 ~ 4, every 0.3 ~ 0.4g, every day three times.
Embodiment 2
The preparation method of rheumatic pain killing capsule, its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (stir-fry) 18.8 g, Olibanum (stir-fry) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0 g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis adds water moistening, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter, merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters, merging filtrate;
4. the medicinal residues after step 3. being extracted add 8 times amount 85% ethanol extraction 2 times, each 1.5 hours, filter, merging filtrate, and reclaim ethanol extremely without alcohol taste, by 5 times amount hot water, temperature 90 DEG C, fully dissolve, filtered while hot, filtrate is concentrated into paste, for subsequent use;
5. by step 2. with step 3. in filtrate add step 1. distill after aqueous solution, being concentrated into relative density is 1.30,60 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (stir-fry) add 8 times amount ethanol (90%), 50 DEG C, soak 3 times, each 24 hours, filter, merging filtrate, reclaim ethanol to without alcohol taste, are concentrated into paste, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (stir-fry), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use;
By step 4., 5., 6. gained thick paste merge, get step 7. mixed 30 minutes of crude drug dried bean noodles, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mixing, make granule, dry, granulate, spray into step 1. gained volatile oil, moistening, makes granule, incapsulates, make 1000, to obtain final product.
Claims (1)
1. treat a preparation method for the rheumatic pain killing medicine of rheumatic arthritis and rheumatoid arthritis, its step is as follows:
(1) crude drug: Cortex Phellodendri 78.0 g, Rhizoma Atractylodis 78.3 g, Radix Clematidis 58.6 g, Caulis Spatholobi 78.0 g, Nidus Vespae 38.8 g, Zaocys 58.0 g, Bungarus Parvus 27.0 g, Agkistrodon 18.7 g, Flos Carthami 11.6 g, Eupolyphaga Seu Steleophaga 7.5 g, Myrrha (parched) 18.8 g, Olibanum (parched) 18.8 g, Radix Angelicae Pubescentis 19.6 g, Scorpio 18.7 g, Scolopendra 11.5 g, Pheretima 20.0 g, Rhizoma Et Radix Notopterygii 19.6 g, Ramulus Cinnamomi 10.0g, Rhizoma Curcumae Longae 12.0 g;
(2) preparation method:
1. get Rhizoma Atractylodis, Radix Clematidis adds water moistening, after running through, steam, distills 6 hours, extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii add water moistening, and after running through, steam, distills 6 hours, extract volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is for subsequent use;
2. the medicinal residues of Rhizoma Atractylodis, Radix Clematidis and Flos Carthami decoct with water three times, and amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filter, merging filtrate;
3. the medicinal residues of Rhizoma Curcumae Longae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii and Cortex Phellodendri, Caulis Spatholobi are decocted with water three times, amount of water is followed successively by 10,8,8 times, and the time is followed successively by 2,1.5,1 hours, filters, merging filtrate;
4. the medicinal residues after step 3. being extracted add 8 times amount 85% ethanol extraction 2 times, each 1.5 hours, filter, merging filtrate, and reclaim ethanol extremely without alcohol taste, by 5 times amount hot water, temperature 90 DEG C, fully dissolve, filtered while hot, filtrate is concentrated into paste, for subsequent use;
5. by step 2. with step 3. in filtrate add step 1. distill after aqueous solution, being concentrated into relative density is 1.30,60 DEG C, extractum, for subsequent use;
6. Nidus Vespae, Olibanum (parched) add 8 times amount 90% ethanol, 50 DEG C, soak 3 times, each 24 hours, filter, merging filtrate, reclaim ethanol to without alcohol taste, are concentrated into paste, for subsequent use;
7. Bungarus Parvus, Agkistrodon, Zaocys, Eupolyphaga Seu Steleophaga, Myrrha (parched), Scorpio, Scolopendra, Pheretima, Ramulus Cinnamomi nine taste crude drug are pulverized, and sieve for subsequent use; By step 4., 5., 6. gained thick paste merge, get step 7. mixed 30 minutes of crude drug dried bean noodles, then add above-mentioned steps 4., 5., 6. gained extractum wet mixing 30 minutes, mixing, make granule, dry, granulate, spray into step 1. gained volatile oil, moistening, makes granule, incapsulates, make 1000, to obtain final product; In the granule prepared, the content of berberine hydrochloride is not less than 0.3mg/g.
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| CN106822185A (en) * | 2017-04-05 | 2017-06-13 | 贵州健瑞安药业有限公司 | A kind of composition for treating rheumatoid and preparation method thereof |
| CN107375759A (en) * | 2017-09-05 | 2017-11-24 | 夏季 | A kind of medicine for treating rheumatic arthritis and preparation method thereof |
| CN109395015B (en) * | 2018-10-25 | 2021-09-07 | 通化金马药业集团股份有限公司 | The use of traditional Chinese medicine composition for rheumatism and pain relief in the preparation of anti-angiogenesis drugs |
| CN114177239A (en) * | 2022-01-18 | 2022-03-15 | 周奕达 | Plaster and preparation method thereof |
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| Title |
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| 任璇璇,等.类风湿性关节炎的中医治疗进展.《浙江中医杂志》.2011,第46卷(第1期),第70-72页. * |
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