CN101769901B - Liquid phase chromatography data processing system based on FPGA - Google Patents

Abstract

The invention discloses an FPGA-based liquid chromatography data processing system. The system includes: an analog/digital conversion module, which receives an analog voltage signal output by a liquid chromatography instrument and converts the analog voltage signal into a digital signal; the FPGA module , preprocess the received digital signal, and generate a digital fingerprint, and then perform an intelligent operation on the generated fingerprint signal to obtain the evaluation data of the drug quality, and at the same time, transmit the calculated value in the form of a digital signal to the signal protocol conversion module; the signal protocol conversion module converts the digital signal transmitted by the FPGA module accordingly, and transmits the converted signal to a display module; the display module performs curve and display of the magnitude. With the FPGA module as the core of the system, the data preprocessing of the entire liquid chromatography fingerprint and the quality assessment process of traditional Chinese medicine can be carried out independently, online, smoothly and quickly.

Description

FPGA-based liquid chromatography data processing system

technical field

The invention relates to a liquid chromatography data processing system, in particular to an FPGA-based liquid chromatography data processing system.

Background technique

The efficacy of traditional Chinese medicine is a summary of the medical practice of the Chinese nation for thousands of years. However, for a period of time, the efficacy of some domestically produced Chinese patent medicines has been questioned in the medical field, especially in general hospitals dominated by Western medicine. To a certain extent, it has affected the reputation of traditional Chinese medicine and hindered the rapid development of the traditional Chinese medicine industry. The main reason is that the quality stability and uniformity of finished products of traditional Chinese medicine are not enough, which leads to unstable and inconsistent curative effect, and the curative effect of individual medicines cannot even be determined; and the root cause is the lack of effective quality control methods for traditional Chinese medicine products. The material basis of the efficacy of traditional Chinese medicine is the complex chemical composition contained in it. The fingerprint technology of traditional Chinese medicine is a method for comprehensively evaluating the substance groups contained in traditional Chinese medicine that reflect the efficacy of traditional Chinese medicine. Since the "Technical Guidelines for Atlas Experimental Research", the research in this field has been continuously broadened and deepened, but we found that the realization of the current technology is only an algorithm software package without corresponding hardware parts, and it needs to be run on the supporting workstation of the liquid chromatograph, which is difficult. It is used in the field of traditional Chinese medicine processing, so it cannot provide any valuable comparison information for the important processing process.

Contents of the invention

In order to solve the above-mentioned problems and defects, the present invention provides an FPGA-based liquid chromatography data processing system.

The present invention is achieved through the following technical solutions:

A kind of FPGA-based liquid chromatography data processing system involved in the present invention comprises:

Analog/digital conversion module, FPGA module, signal protocol conversion module and display module, the

The analog/digital conversion module receives the analog voltage signal output by the liquid chromatograph, and converts the analog voltage signal into a digital signal;

The FPGA module preprocesses the received digital signal and generates a digital fingerprint, and then performs intelligent calculation on the generated fingerprint signal to obtain the evaluation data of the drug quality, and at the same time converts the calculated value into the digital signal The form is transmitted to the signal protocol conversion module;

The signal protocol conversion module converts the digital signal transmitted by the FPGA module accordingly, and transmits the converted signal to a display module;

The display module displays the received digital signal in curve and value and stores it in the host memory at the same time.

The system also includes a power supply device, and the power supply device converts the external AC mains voltage into a DC operating current within 2 amperes, and delivers the current to the entire system. When the FPGA module performs preprocessing operations on digital signals, it also includes a filter processing device and an encoding device. The FPGA module preprocesses the digital signal mainly according to the serial mode of the signal, and after the low-pass filter processing of the signal is realized by adopting the time-recursive filter processing device, it enters the coding device to realize the standard map and the waiting time according to the genetic algorithm of mixed coding. The retention time correction of the measured map eliminates the external interference on the signal. The algorithm of changing the selection, crossover and mutation in the mixed coding genetic algorithm of the coding device into a parallel operation. The analog/digital conversion module converts the voltage signal into a digital signal with a resolution of 8 to 16 bits, and follows the level conversion protocol from TTL to CMOS. The signal protocol conversion module converts TTL level to CMOS level, which can be used for serial communication interface or parallel communication interface.

The beneficial effects of the technical solution provided by the invention are:

Since the FPGA module capable of self-control, multi-channel parallel operation and multiple input and output pins is adopted as the core of the system, the data preprocessing and drug quality evaluation process of the entire drug test can be carried out independently, online, smoothly and quickly.

Description of drawings

Figure 1 is a structure diagram of the FPGA-based liquid chromatography data processing system.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present invention clearer, the implementation of the present invention will be further described in detail below in conjunction with the accompanying drawings:

This embodiment provides a structure of an FPGA-based liquid chromatography data processing system.

Referring to Fig. 1, this system structure mainly comprises power supply device 10, analog/digital conversion module 20, FPGA module 30, signal protocol conversion module 40 and display module 50, in described power supply device 10, supply power to whole system by power supply, this power supply The power range is 1-10 watts, the external 220-volt AC mains voltage, and the working current is within 2 amps, and the swing range is kept within ±0.5%. The analog/digital conversion module 20 converts a voltage signal with a duration of 1 to 80 minutes and an amplitude of 0 to 3 volts into a voltage signal with a resolution of 8 to 16 bits, and the signal protocol is TTL (Time To Live, Survival). Time)/CMOS (Complementary Metal-Oxide Semiconductor, Complementary Metal-Oxide Semiconductor) digital signal; Then the FPGA module 30 receives the TTL/CMOS digital signal, and preprocesses the signal to generate a digital fingerprint, and then generates a fingerprint The atlas signal is intelligently calculated to obtain the evaluation data of the quality of the drug, and at the same time, the calculated value is sent to the signal protocol conversion module 40 in the form of a digital signal; when the FPGA module 30 performs a preprocessing operation on the digital signal, the The FPGA module 30 also includes a filter processing device 301 and an encoding device 302 in the digital signal preprocessing process. The FPGA module 30 preprocesses the digital signal mainly according to the serial mode of the signal, by taking the time-recursive filter processing device 301 After low-pass filtering of the signal, enter the coding device 302 to correct the retention time of the standard spectrum and the spectrum to be measured according to the genetic algorithm of hybrid coding, and eliminate external interference on the signal. The selection, crossover and mutation in the mixed encoding genetic algorithm of the encoding device 302 will be changed into an algorithm capable of parallel operation. The FPGA module 30 has a capacity of more than 400,000 Ω, and receives TTL/CMOS digital signals. The required power supply voltage is in the range of 1-5 volts DC, and the power range is 0.3-5 watts.

The signal protocol conversion module 40 converts the digital signal transmitted by the FPGA module 30 accordingly, and transmits the converted signal to a display module 50 and simultaneously stores it by the PC memory 60; the signal protocol conversion module 40 mainly adopts RS232 signal protocol converter, which converts the upper-level TTL/CMOS protocol signal into RS232 protocol signal by the RS232 signal protocol converter, and sends the signal to the PC host for display on the LCD display. The working voltage of the display is 3 ~10 VDC and displays the curve and magnitude of the received digital signal.

The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed in the present invention can easily think of changes or Replacement should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.

Claims (5)

1. The liquid phase chromatography data processing system based on FPGA is characterized in that, comprises analog/digital conversion module, FPGA module, signal protocol transfer module and display module, described The analog/digital conversion module receives the analog voltage signal output by the liquid chromatograph, and converts the analog voltage signal into a digital signal; The FPGA module preprocesses the received digital signal and generates a digital fingerprint, and then performs intelligent calculation on the generated fingerprint signal to obtain the evaluation data of the drug quality, and at the same time converts the calculated value into the digital signal The form is transmitted to the signal protocol conversion module; The signal protocol conversion module converts the digital signal transmitted by the FPGA module accordingly, and transmits the converted signal to a display module; The display module displays the received digital signal in curve and value and stores it in the host memory at the same time. 2. according to the described FPGA-based liquid chromatography data processing system of claim 1, it is characterized in that, described system also comprises power supply unit, and this power supply unit converts external AC city voltage into the DC operating current within 2 amperes, and Send its current to the whole system. 3. the liquid phase chromatography data processing system based on FPGA according to claim 1, is characterized in that, when described FPGA module carries out preprocessing operation to digital signal, also comprises a filter processing device and encoding device. 4. according to the described FPGA-based liquid chromatography data processing system of claim 1 or 3, it is characterized in that, said FPGA module carries out preprocessing to digital signal mainly according to the serial mode of signal, by taking time recursive filter processing After the device realizes the low-pass filtering processing of the signal, it enters the encoding device to realize the retention time correction of the standard spectrum and the spectrum to be measured according to the genetic algorithm of mixed coding, and eliminates the external interference on the signal. 5. The liquid chromatography data processing system based on FPGA according to claim 4, characterized in that, the selection, crossover and variation in the coding device hybrid coding genetic algorithm are changed to parallel computing algorithms.

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